Gene TK4 (Sea Urchin)
TK4
Sequence
Protein domains of TK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | TK4.AA | TK-Unique | 10-228 | 35 | 1.1e-85 | 291.0 | In-house | 40-269 (294) | Show / Hide |
Range on Protein: 10-228 Range on HMM: 40-269/294 Sequence Identity: 35% (89 aa) DRDQVTKSTNVLQTVKELCELTDQQNVVRCLGYCQ---EQGSILYEFISGGTLLTYLQTTG-LQSQP-TYGNLK------PKRVR---LDEGSLLNLAWQ |. . |. . |. . . ||.|..|.|.|||.|. |. |..|....|.|..||.|.. ..|. |||||| |...| .....|.. ||| DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQ IAKGMQYLAS--KKVTLLLDLHEENGQRKMGRIIHGTLCAHNVLLAERKQCKLSDYGLS---------ASLFSDKYKSTRWSSPENMI--TGDQ-STEGD ||.||.|||| ||. .|..|||.||||.|.|.||..|.|.. .. | . . || .|| . .| .|..| IACGMEYLASQRKKI------------------VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSD IWSFGVVLWEIVTLGARPYPNMIFDTVQSEVPNGYQMPRPRHC-GQEV .|||||..|||.||||.|||.| . .. ....|| ||.| || .|. VWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEM |
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| Kinase | TK4.AA | TK | 21-228 | 18 | 3.2e-52 | 172.95 | In-house | 89-461 (486) | Show / Hide |
Range on Protein: 21-228
Range on HMM: 89-461/486
Sequence Identity: 18% (71 aa)
LQTVKELCE-LTDQQNVVRCLGYCQEQG--------------SILYEFISGGT----LLTYLQTTGL---QSQPTYGNLKPKRVR---------------
.. | .|. | . .|.||..|.| ... |. |. ..| |..||.. ..|....|...|...
AEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSH
-------------------------------------------LDEGSLLNLAWQIAKGMQYLASKKVTLLLDLHEENGQRKMGRIIHGTLCAHNVLLAE
|. || .||||.||.||.||... . ...|. |.|.|.|..|
ESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-F-----------IQNFVHRDLAARNCLVGE
RKQ-----------CKLSDYG--------LSASLFS--DKYKST------------------------------RWSSPENMI---------TGDQSTEG
... ||..|.| |. . | | |... || .|| . .| .|.
NNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKS
DIWSFGVVLWEIVTLG-ARPYPNMIF---------DTVQSEVPNG--------------YQMPRPRHCG--------------QEV
|.|||||..|||.|.| . .|..| . | . .| ..||.| || .|.
DVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEY
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| Kinase | TK4.AA | Pkinase_Tyr | 34-228 | 31 | 7.9e-37 | 125.36 | Pfam | 64-245 (270) | Show / Hide |
Range on Protein: 34-228 Range on HMM: 64-245/270 Sequence Identity: 31% (67 aa) QNVVRCLGYCQ-EQGS----ILYEFISGGTLLTYLQTTGLQSQPTYGNLKPKRVRLDEGSLLNLAWQIAKGMQYLASKKVTLLLDLHEENGQRKMGRIIH .|.||..| | .... | |. .| ||.||.. . . .|. ||. .|||||||.||.||. .|| PNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKN------------------CIH GTLCAHNVLLAERKQCKLSDYGLSASL-FSDKY-KST-------RWSSPENMITGDQSTEGDIWSFGVVLWEIVTLGARP-YPNMIFDTVQSEV-PNGYQ |.| |.|..| ...| .| ||. . | | ... .| .|| . .| .|. |.|||||..|||.|.|. | ||.| | . .||. RDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR MPRPRHCGQEV ||.|..| .|. MPCPENCPDEI |
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| Kinase | TK4.AA | TKL | 34-194 | 21 | 3.2e-25 | 87.76 | In-house | 85-284 (364) | Show / Hide |
Range on Protein: 34-194
Range on HMM: 85-284/364
Sequence Identity: 21% (51 aa)
QNVVRCLGYCQEQG---------------SILYEFISGGTLLTYLQTTGLQSQPTYGNLKPKRVRLDEGSLLNLAWQIAKGMQYLASKK---VTLLLDLH
.|.|...|||.. . | .|...||.|| ||. ....| .||.||.|| |.. |
PNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------------WHQRCRWALDIARGMNYLHSMNPKWCT------
EENGQRKMGR--IIHGTLCAHNVLLAERKQ--------------CKLSDYGLSASLFSDKY------------------------K-STRWSSPENMITG
||| | .|.|. | . ||..|.||| ... .. ..|| .|| .
---------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQ
DQSTEG----------------DIWSFGVVLWEIVT
.. || |..|||.|||||.|
MNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT
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| Kinase | TK4.AA | UTK | 125-228 | 32 | 6.3e-25 | 82.21 | In-house | 138-271 (296) | Show / Hide |
Range on Protein: 125-228 Range on HMM: 138-271/296 Sequence Identity: 32% (43 aa) RIIHGTLCAHNVLLAER-------KQCKLSDYG---LSASLF----------SDKYKST-------RWSSPENMITG-DQSTEGDIWSFGVVLWEIVTLG ...|. |.| |.|... .||..|.| .| . |. |... || .|| .. . . .| |.||||||.|||.| | GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWG ARPYPNMIFDTVQSEVPNG--YQMPRPRHCGQEV ..|||.| . | .| || |.||.|..|. .| RLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPV |
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| Kinase | TK4.AA | Src | 125-228 | 38 | 1.8e-21 | 69.63 | In-house | 117-229 (255) | Show / Hide |
Range on Protein: 125-228 Range on HMM: 117-229/255 Sequence Identity: 38% (43 aa) RIIHGTLCAHNVLLAERKQCKLSDYGLSASLF--SDKYKST-------RWSSPENMITGDQSTEGDIWSFGVVLWEIVTLGARPYPNMIFDTVQSEVPNG ..|| | | ||| | || | || . | | . .| || | .. | ||||. |.|||| | ||| | | .| .| NYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERG YQMPRPRHCGQEV | ||.|..| .|. YRMPCPHNCPDEL |
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| Kinase | TK4.AA | Src-Echino1 | 126-224 | 35 | 3.3e-21 | 69.94 | In-house | 117-222 (252) | Show / Hide |
Range on Protein: 126-224 Range on HMM: 117-222/252 Sequence Identity: 35% (38 aa) IIHGTLCAHNVLLAERKQCKLSDYGLSASLFSDKYKST-------RWSSPENMITGDQSTEGDIWSFGVVLWEIVTLGARPYPNMIFDTVQSEVPNGYQM ..| | |.|||... ||. |.|| . | | . .| .|| . | |.||||... |.|| | |||.| | .| .||.| VVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPGMMNREVLDQVDRGYRM PRPRHC |.. || PKMHHC |
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| Kinase | TK4.AA | Abl | 127-228 | 35 | 3.4e-20 | 63.62 | In-house | 119-227 (252) | Show / Hide |
Range on Protein: 127-228 Range on HMM: 119-227/252 Sequence Identity: 35% (39 aa) IHGTLCAHNVLLAERKQCKLSDYGLSASLFSDKYKST-------RWSSPENMITGDQSTEGDIWSFGVVLWEIVTLGARPYPNMIFDTVQSEVPNGYQMP || | | | |..| . |. |.||. . | | .| || . |. |.| |||.|||| | | ||| . | . .|| | IHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRME RPRHCGQEV ||. | ..| RPEGCPPKV |
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| Kinase | TK4.AA | TyrKc | 15-228 | 23 | 9.7e-16 | 31.76 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 15-228
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)
TKSTNVLQT----------------VKELC---------------EL-TDQQNVVRCLGYCQ---------EQGSILYEFISGGTLLTYLQTTGLQSQPT
. .| || | .| . .|.||..|.| |. |. |. ..| |. ||. .. .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----
YGNLKPKRVRLDEGSLLNLAWQIAKGMQYLASKKVTLLLDLHEENGQRKMGRIIHGTLCAHNVLLAERKQCKLSDYGLSASLFSD-------KYKS----
| ||. .||||.||.||.|| ..|| | | |.|..|....| || ||| . .| .|..
----------LCMKDLLSFCWQIACGMEYLHSK------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEH
--TR------WSSPENMITGDQSTEGDIWSFGVVLWEIVTLGARPYPN-----MIFDTVQSEVPNGYQMPRPRH--------------------------
.. | .|| . .| .|. |.|||||..||| |.|. |||. | . | | .|| ||.| .
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE
-------CGQEV
. ..
DRPTFSEIHECF
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| Kinase | TK4.AA | VEGFR | 126-201 | 37 | 2.5e-14 | 50.58 | In-house | 194-279 (332) | Show / Hide |
Range on Protein: 126-201 Range on HMM: 194-279/332 Sequence Identity: 37% (32 aa) IIHGTLCAHNVLLAERKQCKLSDYGLSAS-LFSD---KYKST------RWSSPENMITGDQSTEGDIWSFGVVLWEIVTLGARPYP .||. | | |.||.| . | .| ||. . . .| . | .| .|| .| |.||.||.|||| .||. ||| CIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYP |
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| Kinase | TK4.AA | FGFR | 178-228 | 38 | 1.6e-13 | 42.37 | In-house | 217-268 (293) | Show / Hide |
Range on Protein: 178-228 Range on HMM: 217-268/293 Sequence Identity: 38% (20 aa) TEGDIWSFGVVLWEIVTLGARPYPNMI-FDTVQSEVPNGYQMPRPRHCGQEV .. |.||.|| |||| |.| ||| . |. | .| .| ||. HQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEI |
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| Kinase | TK4.AA | Ret | 181-228 | 47 | 9.2e-13 | 39.88 | In-house | 219-266 (293) | Show / Hide |
Range on Protein: 181-228 Range on HMM: 219-266/293 Sequence Identity: 47% (23 aa) DIWSFGVVLWEIVTLGARPYPNMIFDTVQSEVPNGYQMPRPRHCGQEV |.||||| .|||||.|| ||| . . || | || | |. DVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEM |
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| Kinase | TK4.AA | Pkinase | 35-194 | 19 | 7.6e-10 | 35.9 | Pfam | 61-207 (293) | Show / Hide |
Range on Protein: 35-194 Range on HMM: 61-207/293 Sequence Identity: 19% (35 aa) NVVRCLGYCQEQGSIL--YEFISGG----TLLTYLQTTGLQSQPTYGNLKPKRVRL--DEGSLLNLAWQIAKGMQYLASKKVTLLLDLHEENGQRKMGRI |.||....... ..| |. || | .|..| .. .. .| . . ..||..|..|. |. .| NIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSM------------------GI IHGTLCAHNVLLAERKQC----KLSDYGLSAS--LFSDKYKST-----RWSSPENMI-TGDQSTEGDIWSFGVVLWEIVT || | |.|. .. .. |..| ||.. . .. .| .. .|| . ... |.||.|..|.| .. IHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC |
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| Kinase | TK4.AA | UTK | 34-108 | 29 | 1.7e-09 | 28.68 | In-house | 70-139 (296) | Show / Hide |
Range on Protein: 34-108 Range on HMM: 70-139/296 Sequence Identity: 29% (23 aa) QNVVRCLGYCQEQGS--ILYEFISGGTLLTYLQTTGLQSQPTYGNLKPKRVRLDEGSLLNLAWQIAKGMQYLASKKV .||.| .|.| .. |..|. ..| |..||.. . . . .. |.. ..| ||.|| |||||.|... PNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGF |
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| Kinase | TK4.AA | FGFR | 89-108 | 55 | 1.6e-07 | 21.63 | In-house | 138-157 (293) | Show / Hide |
Range on Protein: 89-108 Range on HMM: 138-157/293 Sequence Identity: 55% (11 aa) LLNLAWQIAKGMQYLASKKV | .|.|.|.||.||||.|. LVSCAYQVARGMEYLASRKC |
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| Kinase | TK4.AA | Src | 52-108 | 29 | 4.4e-07 | 20.04 | In-house | 74-118 (255) | Show / Hide |
Range on Protein: 52-108 Range on HMM: 74-118/255 Sequence Identity: 29% (17 aa) EFISGGTLLTYLQTTGLQSQPTYGNLKPKRVRLDEGSLLNLAWQIAKGMQYLASKKV |. | | ||.||. ... .| |. .|.|.|.||.|| |... EYMSHGSLLDYLKK------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNY |
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| S_TKc | TK4.AA | S_TKc | 3-226 | 18 | 4e-06 | -86.49 | SMART | 16-220 (231) | Show / Hide |
Range on Protein: 3-226 Range on HMM: 16-220/231 Sequence Identity: 18% (46 aa) YEMIQNG-DRDQVTKSTNVLQTVKELCELT-DQQNVVRCLGYCQ-EQGSILYEFISG--GTLLTYLQTTGLQSQPTYGNLKPKRVRLDEGSLLNLAWQIA | . .. .| | . .. .|. | . |.|......| . . |...| |.|..|.. | . ..|....| ...||. YKCRHKKTGRIVAIKIIK-EHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH---------GLRFPFPE-HARFYMYQIC KGMQYLASKKVT--------LLLDLHEENGQRKMGRIIHGTLCAHNVLLAERKQCKLSDYGLSASLFSDKYKSTRW-SSPENMITGDQST-EGDIWSFGV ....|. |... .||| . |..| ||.. | . . |.| .|| . .. . |.||.|. CALEYCHSHGIIHRDLKPENILLDE----------------------------HIKICDFGLARQL--TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC VLWEIVTLGARPYP--NMIFDTVQSEVPNGY--------QMPR----PRHCGQ .|.| .. | |.| .|.|. . | . |. . | ILYEMLC-GYPPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQ |
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| Kinase | TK4.AA | Ret | 87-108 | 45 | 6e-06 | 16.28 | In-house | 135-156 (293) | Show / Hide |
Range on Protein: 87-108 Range on HMM: 135-156/293 Sequence Identity: 45% (10 aa) GSLLNLAWQIAKGMQYLASKKV . .. |||| |||.||.. |. KMIISFAWQICKGMHYLSEMKL |
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| Kinase | TK4.AA | VEGFR | 89-109 | 42 | 2.8e-05 | 16.07 | In-house | 175-195 (332) | Show / Hide |
Range on Protein: 89-109 Range on HMM: 175-195/332 Sequence Identity: 42% (9 aa) LLNLAWQIAKGMQYLASKKVT |.. . |.|.|| .|||.|.. LICYSFQVARGMEFLASRKCI |
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| Kinase | TK4.AA | Ret | 126-152 | 51 | 2.8e-05 | 13.93 | In-house | 156-182 (293) | Show / Hide |
Range on Protein: 126-152 Range on HMM: 156-182/293 Sequence Identity: 51% (14 aa) IIHGTLCAHNVLLAERKQCKLSDYGLS ..| | | |||.|| . || ||.||. LVHRDLAARNVLVAEGRICKISDFGLT |
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| Kinase | TK4.AA | Abl | 34-107 | 32 | 0.001294 | 7.37 | In-house | 55-117 (252) | Show / Hide |
Range on Protein: 34-107 Range on HMM: 55-117/252 Sequence Identity: 32% (25 aa) QNVVRCLGYCQEQGS--ILYEFISGGTLLTYLQTTGLQSQPTYGNLKPKRVRLDEGSLLNLAWQIAKGMQYLASKK .|.|. || | |. ||.. | || || .. | |. || .| ||| ||.|| ... PNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECD-------------REELPAVVLLYMATQIASGMSYLEKRH |
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| Kinase | TK4.AA | FGFR | 125-152 | 39 | 0.008176 | 5.36 | In-house | 156-183 (293) | Show / Hide |
Range on Protein: 125-152 Range on HMM: 156-183/293 Sequence Identity: 39% (11 aa) RIIHGTLCAHNVLLAERKQCKLSDYGLS ..|| | | ||| . | .|.||. KCIHRDLAARNVLVTDDYVMKICDFGLA |
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