Gene CG11489 (Fruit Fly)

CG11489

Species: Fruit Fly
Alias: CG11489, SRPK1, CG9085, CK01209
External Links: Flybase Link
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
CG11489.AA Protein None 880 None Fasta, JSON
CG11489.kin_dom Protein Kinase Domain None 308 None Fasta, JSON

Protein domain

Protein domains of CG11489.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CG11489.AA SRPK 382-874 24 3.3e-174 453.4 In-house 303-554 (554) Show / Hide 
Range on Protein: 382-874
Range on HMM: 303-554/554
Sequence Identity: 24% (121 aa)

NQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATNSNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSS
..|. |                                                                                              
QKQNND----------------------------------------------------------------------------------------------

LLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCDEDAESDTLGEQSTLASTMDSPTDLDPEPELDSKPNTVPEPTTIAKSKINSNILSTCTSLTSTNE
                                                                                                    
----------------------------------------------------------------------------------------------------

YCFTNTNTTTASTPSAPPSATPSSAPALASATPPSTCTPSFTQIAPSATAPATSTTCTTSAEFYDGDHKTTSTSTTTTSNAISSATTTTATTTTAIAKLN
                                             |..     |..  .. .   . ||.  |   . |. ...... .......  .  
---------------------------------------------PNFESQNDSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQDQQKEGQKQSEESE

VHANAIPSQNQSQSSQNNTYTIQS----LID-NSNVRVKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHA
.    ...|       .  ..       ..| . ....|||||||||. .||||||||||||||.||..||.||..||||||||.|||||||||||.||.
CESEDMQEQ-------AGKFLVWWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHS

GESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL
||.||||.||.|||.||.|.||......||.. ..|...|.||.|.|||||.|||||.|||.|.. |||.|.|||.|||.|||  ||.|.||||||||
GEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase CG11489.AA SRPK 232-378 52 5.9e-140 363.06 In-house 1-168 (554) Show / Hide 
Range on Protein: 232-378
Range on HMM: 1-168/554
Sequence Identity: 52% (88 aa)

FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPM---------------------DVKRERIVRLMNHFTVRGVNG
..|.||||||||||||||.|.....|||.|.|||||||.|||.|||.||...|..||.                     | .|...|.|..||..||.||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

MHTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNA
.|.|.||| ||..|.|.| ..||||.....|..|.||||.||||||.||.||||||||||.|| ....
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQD
Kinase CG11489.AA CMGC 232-874 13 6.8e-115 379.19 In-house 1-513 (513) Show / Hide 
Range on Protein: 232-874
Range on HMM: 1-513/513
Sequence Identity: 13% (110 aa)

FRVVRKLGWGHFSTVWLCRD--------------LKDEKYVALKVVKSAPHYIETAA-------------DEIRLLEAIR----------DADPMDVKRE
. ...|.|.|....|. |||               .....||.| .|... | |.|              .||..|. ..          | ||.. ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

RIVRLMNHFTVRGVNGM-------------HTCLVFEALGCSLYKLIVKNN--YQG------------------------LAIAQVRNIIRQVLEGLD--
 ||.| ..|. .. .|              | .|||| ....||..| .|.  |||                        . | ..| ...|.|.||.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YLHSKC-SIIHTDIKPENILLVID-----------NAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATNSN
|.||.. .|||.|.||||||.  .           .                                                                
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSE----------------------------------------------------------------

SSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCDEDAESDTLGEQSTLASTMDSPTDL
                                                                                                    
----------------------------------------------------------------------------------------------------

DPEPELDSKPNTVPEPTTIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTPSAPPSATPSSAPALASATPPSTCTPSFTQIAPSATAPATSTTCTTS
                                                                                                    
----------------------------------------------------------------------------------------------------

AEFYDGDHKTTSTSTTTTSNAISSATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACYDYHH-------------
                                                          .    ..  ..| |.||.| |.|..  .|             
----------------------------------------------------------D-W-NPC--QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFK

-----------FTEDIQTRQYRSIEVLLGAP----------YNYTADIWSTACLAFELATG--------DYLFDPHAGE-----SYSRDEDHLAHIVELL
           .|....|| ||. |.|||..          |... |.|| .|  .|. ||        ..|| .| ..     ..... |.|..|...|
NVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVL

GSIPQSVIFRGK-------HGLKYFTSYGSLRNITKLK-------------------------PWSLMNVLVEKYDWDPV--------------------
|... ..| .||       |  ....  . .......|                         ||   . . ... |.|                     
GTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFK

------------EAKKFSDFLLPMLEYNPVIRASAAECLQHPWL
            . ... |.|  ||.|.|  | .|...||||..
SHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CG11489.AA CLK 232-874 16 2e-75 225.41 In-house 1-350 (350) Show / Hide 
Range on Protein: 232-874
Range on HMM: 1-350/350
Sequence Identity: 16% (110 aa)

FRVVRKLGWGHFSTVWLCRDLKDEK-YVALKVVKSAPHYIETAADEIR-LLEAIRDA-DPMDVKRERIVRLMNHFTV-RGVNGMHTCLVFEALGCSLYKL
. .| .|| | |..|  |.| | .| |||||.....  | | |  ||.  ...|  . ||   ..| ....   |    |    | |.||| .| |.| .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHG----HICIVFELYGLSIYDF

IVKNN------YQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVID----NAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKW
. .||      |... |...|.. .| .| .  || . ...||| |||||..|       .  .  .. . ||                           
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKIN---------------------------

PLIEPNGSTNTNTNTSNSTATNSNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCD
                                                                                                    
----------------------------------------------------------------------------------------------------

EDAESDTLGEQSTLASTMDSPTDLDPEPELDSKPNTVPEPTTIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTPSAPPSATPSSAPALASATPPST
                                                                                                    
----------------------------------------------------------------------------------------------------

CTPSFTQIAPSATAPATSTTCTTSAEFYDGDHKTTSTSTTTTSNAISSATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIA
                                                                            .| .|.   ....    |  ... 
---------------------------------------------------------------------------KKS-NNCVCHYWHVK---NTHICVI

DLGNAC---YDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLG-SIPQSVIFRG---KHGLK
| |.|    .|. | .. ..||.||  || || ....  |.|| .|  ||| ||. ||. |         .||| . ...|  |||. | |    |   |
DFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NREHLAMMERIMGMPIPQWMIQRTRRFKVKQK

YFTSYGSLRNITKLKPWSLMNV---LVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL
||  .. . . .. .  . |     | .  | .  |. .. | .  |||| |  | .... ||||. 
YFYHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase CG11489.AA S_TKc 232-874 11 4.7e-47 163.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 232-874
Range on HMM: 1-231/231
Sequence Identity: 11% (75 aa)

FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGC---SLYKLI
....||.| | |..|..||. |. ..||.|..|      |..  ||..|.          . . ||.|  .|        | ..|.| ..    .|...|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYI

VKNNYQG----LAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNG
.|....|    .   ..| ...|....|.|.||.  ||| |.|||||||                   ..|  ||  . .                    
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-----------------HIKICDFGLARQL-------------------

STNTNTNTSNSTATNSNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCDEDAESDT
                                                                                                    
----------------------------------------------------------------------------------------------------

LGEQSTLASTMDSPTDLDPEPELDSKPNTVPEPTTIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTPSAPPSATPSSAPALASATPPSTCTPSFTQ
                                                                                                    
----------------------------------------------------------------------------------------------------

IAPSATAPATSTTCTTSAEFYDGDHKTTSTSTTTTSNAISSATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACY
                                                                                                    
----------------------------------------------------------------------------------------------------

DYHHFTEDIQTRQYRSIEVLLGAPYNY-TADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITK
     |  . |. |.. |||   .|..  .|.||  |. .|...|  .|.            ... . ...|                            
-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG----------------------------

LKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQ-------HPWL
                     . . ||.  .|...|  | .| |.||       |||.
--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG11489.AA DYRK 232-374 34 6.3e-41 142.28 In-house 1-138 (320) Show / Hide 
Range on Protein: 232-374
Range on HMM: 1-138/320
Sequence Identity: 34% (49 aa)

FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKN
....  .| | |. |  |.| |  ..||.|.... . .  .| .||..|| ....|| |  . ..|.. ..|. |    .|.|.||| |  .|| .. .|
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDD--KYHCVHMYDYFYHR----NHLCIVFELLSMNLYEFLKNN

NYQGL-AIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLV
. ||.  .  || ...|.|..|..||.. .||| |.|||||.|.
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLK
Kinase CG11489.AA DYRK2 232-373 35 4e-36 114.73 In-house 1-135 (318) Show / Hide 
Range on Protein: 232-373
Range on HMM: 1-135/318
Sequence Identity: 35% (51 aa)

FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKN
. ..  .| | |  |  | | | ...||.|..     . ..|. ||| |..||  |.       .|.. . |. |.    |.|..|| |. .||..| ||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDN--TMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKN

NYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILL
..||.. . ||  ....|..|. || |  ||| | |||||||
HFQGFSLQLVRRFAHSILQCLRFLH-KNNIIHCDLKPENILL
Kinase CG11489.AA Pkinase 232-374 26 1.9e-27 98.11 Pfam 1-142 (293) Show / Hide 
Range on Protein: 232-374
Range on HMM: 1-142/293
Sequence Identity: 26% (42 aa)

FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAAD------EIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGC---
....||.| | |..|..|.. ...| ||.|..|   |  .          ||...  ..         . ||||   |.     . | ..|.| ...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFED----KDHIYMVMEYCEGGLY

--SLYKLIV---KNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLV
  .|. .|    ....  .   .......|.|.||.|.|| ..||| |.||||||..
VMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID
Kinase CG11489.AA YAK 232-373 33 6e-25 81.36 In-house 1-139 (347) Show / Hide 
Range on Protein: 232-373
Range on HMM: 1-139/347
Sequence Identity: 33% (48 aa)

FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRD-ADPMDVK-RERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIV
. |   || | |  |  |. .  .  .| ||.|. . |   |  ||..|.   .  || .     .|.|..  |  .    .| ||||| |  .|| .. 
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHK----NHFCLVFEMLSNNLYEYLK

KNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILL
 |.. |. .  .|    |.|.|.  | .|  ||| | |||||.|
QNKFCGFSFQLIRQWTKQILDGMCVLENK-QIIHCDLKPENIML
Kinase CG11489.AA DYRK1 232-374 34 6.9e-24 80.4 In-house 1-138 (321) Show / Hide 
Range on Protein: 232-374
Range on HMM: 1-138/321
Sequence Identity: 34% (49 aa)

FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKN
. .   .| | |  |    | ....|||.|..|    ... |  |||||| .  .|. .  . .||.| .||  |     | ||||| |   || |.   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEM--KYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNT

NYQGLAIAQVRNIIRQVLEGLDYLHS-KCSIIHTDIKPENILLV
...| ..  .| . .|..  | .. .   .||| |.|||||||.
HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLC
Kinase CG11489.AA DYRK 713-874 28 1.3e-23 84.82 In-house 145-320 (320) Show / Hide 
Range on Protein: 713-874
Range on HMM: 145-320/320
Sequence Identity: 28% (52 aa)

RVKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRG--KHGLK
..|..| | .|.  ....  || | ||. ||.|| ||.|  |.||  |   || ||  ||   .||..    | || |.|.|| .|. .|  |  ..  |
TIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKGRCRRKHK

YFTS------------------YGSLRNITKLKPWSLMNVLVE--KYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL
.|..                  |. .... ...  . .    .  ..  .  . ..| ||.. .|...|  | .... |||||.
FFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase CG11489.AA CDK 706-874 26 5.4e-17 50.75 In-house 140-284 (284) Show / Hide 
Range on Protein: 706-874
Range on HMM: 140-284/284
Sequence Identity: 26% (49 aa)

LIDNSNV----RVKIADLGNACYDY---------HHFTEDIQTRQYRSIEVLLGAP-YN--YTADIWSTACLAFELAT---GDYLFDPHAGESYSRDEDH
||.|  .    |.|||| | |.              .|  . |. ||. |.|||.  |.   . |.||  |   |..|   . .||    |.|     | 
LINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLF---PGDSE---IDQ

LAHIVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL
| .| ...|. |   .  |   | ..                                    |.|  || |.|  | || ..||||..
LFKIFRICGT-PTEDNWPGVTKLPDY------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CG11489.AA DYRK1 714-813 39 1.5e-16 54.16 In-house 145-238 (321) Show / Hide 
Range on Protein: 714-813
Range on HMM: 145-238/321
Sequence Identity: 39% (39 aa)

VKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYFT
.|| | | .|   .   . || | ||| ||||| .|.   |.||  |.  |. ||. ||      | | . | . .||| ||  |. .| ..    |||.
IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF------SGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE
Kinase CG11489.AA DYRK2 714-803 36 3.2e-15 45.64 In-house 143-226 (318) Show / Hide 
Range on Protein: 714-803
Range on HMM: 143-226/318
Sequence Identity: 36% (33 aa)

VKIADLGNACYDYH-HFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIF
.|..| |  |...  ..  .||.| ||. || || .|.   |.||  | . || ||  ||   .|| .    | .| . |.|| .| ...|
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLG-MPPKKFF
Kinase CG11489.AA DyrkP 710-772 41 3.6e-15 45.73 In-house 143-205 (323) Show / Hide 
Range on Protein: 710-772
Range on HMM: 143-205/323
Sequence Identity: 41% (26 aa)

SNVRVKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLF
.  .||| | | .|.   |    .| | ||  ||..|  | |  |.||  |.  || ||  ||
PKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF
Kinase CG11489.AA Pkinase 706-874 22 5.7e-14 50.47 Pfam 140-293 (293) Show / Hide 
Range on Protein: 706-874
Range on HMM: 140-293/293
Sequence Identity: 22% (40 aa)

LIDNSNVR---VKIADLGNAC---YDYHHFTEDIQTRQYRSIEVLL-GAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLG---
|||| ..    |||.| | |.   | .. .|    |. |.. ||.. | .| . .|.||  |. .|...|  .|. ...    .  |... |.. .|   
LIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPL

--SIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL
  ..|..   .  . ... .                           .   . . ||.  .|...|  | .|...|||||.
HFDWPWWCSISYFF-FRH-W-H------------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CG11489.AA CDK4 296-373 35 2.1e-13 42.15 In-house 65-143 (290) Show / Hide 
Range on Protein: 296-373
Range on HMM: 65-143/290
Sequence Identity: 35% (28 aa)

IVRLMNHFTVRGVNG--MHTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILL
||.||  ..|  . .  |   .|||     |  .. |    |.   ... . .| | |.|.||| . ||| | ||.|||.
IVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHR-IIHRDLKPQNILV
Kinase CG11489.AA DyrkP 232-373 29 5.1e-13 38.54 In-house 1-139 (323) Show / Hide 
Range on Protein: 232-373
Range on HMM: 1-139/323
Sequence Identity: 29% (42 aa)

FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKN
. ..  ||   ||    | |.. .. . .|..     | . . |||.||  |      ||    ..|    |  .    . | |. . |    ||    |
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYN--GDVDEKNVLRYYDYFYHKEHLFIITELLKDNL-YEFYKFNREN

NYQG-LAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILL
  |    .  .  |  |.| .|||.||   .|| |.||||||.
EQQRYFTVGRLQKITQQILIALDYIHS-LRLIHCDLKPENILM
Kinase CG11489.AA CDK 315-373 33 1.5e-10 29.78 In-house 95-141 (284) Show / Hide 
Range on Protein: 315-373
Range on HMM: 95-141/284
Sequence Identity: 33% (20 aa)

LVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILL
.||| .   |.|..            ......| |.||.|.||.  |.| |.|| |||.
MVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNW-IMHRDLKPQNILI
Kinase CG11489.AA YAK 714-812 33 2.3e-09 27.56 In-house 147-239 (347) Show / Hide 
Range on Protein: 714-812
Range on HMM: 147-239/347
Sequence Identity: 33% (33 aa)

VKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYF
.|| | | .|.     .  || | ||| |.... .|    | ||  |   ||  |  .| | . | |    . .  |.. ||  |  .| .|.   |||
IKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIF-PGNSE-Y----NQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase CG11489.AA CDK4 849-874 53 9.9e-09 25.86 In-house 265-290 (290) Show / Hide 
Range on Protein: 849-874
Range on HMM: 265-290/290
Sequence Identity: 53% (14 aa)

DFLLPMLEYNPVIRASAAECLQHPWL
|.|. || ||.  | || .|||||..
DLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CG11489.AA CDK4 738-765 46 6.3e-08 23.06 In-house 175-202 (290) Show / Hide 
Range on Protein: 738-765
Range on HMM: 175-202/290
Sequence Identity: 46% (13 aa)

YRSIEVLLGAPYNYTADIWSTACLAFEL
||. |||| ..|| . |.|| .|  .|.
YRAPEVLLQSYYNTPVDMWSVGCIFAEM
Kinase CG11489.AA DYRK2 845-874 33 5e-06 15.16 In-house 289-318 (318) Show / Hide 
Range on Protein: 845-874
Range on HMM: 289-318/318
Sequence Identity: 33% (10 aa)

KKFSDFLLPMLEYNPVIRASAAECLQHPWL
. | ||..  .|  |  | .... |.|||.
ENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase CG11489.AA DYRK1 841-874 32 9e-06 15.66 In-house 288-321 (321) Show / Hide 
Range on Protein: 841-874
Range on HMM: 288-321/321
Sequence Identity: 32% (11 aa)

PVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL
... .|| | .. ||.|.|  | .  . |||...
VEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase CG11489.AA CDK 232-264 26 1.8e-05 13.3 In-house 1-38 (284) Show / Hide 
Range on Protein: 232-264
Range on HMM: 1-38/284
Sequence Identity: 26% (10 aa)

FRVVRKLGWGHFSTVWLCRDLKDE-----KYVALKVVK
.  . |.| |.. .|  .||...      ..|||| ..
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIR
Kinase CG11489.AA DyrkP 847-874 42 3.9e-05 12.1 In-house 296-323 (323) Show / Hide 
Range on Protein: 847-874
Range on HMM: 296-323/323
Sequence Identity: 42% (12 aa)

FSDFLLPMLEYNPVIRASAAECLQHPWL
| ||   .|      | .| | |||||.
FIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase CG11489.AA TyrKc 232-475 17 0.000273 -153.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 232-475
Range on HMM: 1-280/280
Sequence Identity: 17% (55 aa)

FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAI--RDADPMDVKRERIVRLMNHFTVRGVNG---MHTCLVFE-ALGCSLY
 .  .||| |.| .|....       || |..|.    .|   .|.|..  .  .         . ||||    |  | |       ..|.| . . .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHH--------PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

KLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNAAAMNQQIDDEINSLRVKGVDF---PDSYIS--------SIEKQTKSR
. . |.  . |  ..  ..  |. .| .|||||  .|| |.   |.|.  ..               .||  ||    | |           . |.... 
DYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH---------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

AK--WPL---------------------------------IEPNGST----NTNTNTSNSTATN------SN--------SSTPLAAVIMSTLDKEDTTT
.|  .|.                                  .|         .|.   .   .        |         .. .   ||..  .||   
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPED

-TTSSTLNSNTTSSL
  | |..     . .
RPTFSEI----HECF
Kinase CG11489.AA CDK4 232-264 39 0.001438 7.87 In-house 1-33 (290) Show / Hide 
Range on Protein: 232-264
Range on HMM: 1-33/290
Sequence Identity: 39% (13 aa)

FRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVK
.  |  .| | . ||.  |||.. . |||| |.
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVR
Kinase CG11489.AA YAK 847-874 35 0.004302 5.91 In-house 320-347 (347) Show / Hide 
Range on Protein: 847-874
Range on HMM: 320-347/347
Sequence Identity: 35% (10 aa)

FSDFLLPMLEYNPVIRASAAECLQHPWL
| ||.  .|. ||  | ..    ||| .
FIDFINQLLQLNPRERWKPMQAMQHPFI