AqueK100

Species: A.queenslandica
Alias: AqueK100
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK9

Sequence

Name Sequence Type Origin Length Description Download
AqueK100.AA Protein None 288 None Fasta, JSON
AqueK100.kin_dom Protein Kinase Domain None 221 None Fasta, JSON

Protein domain

Protein domains of AqueK100.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK100.AA CDK9 11-234 55 5.70000000001e-144 484.6 In-house 82-340 (340) Show / Hide
Range on Protein: 11-234
Range on HMM: 82-340/340
Sequence Identity: 55% (145 aa)

ATPYNRDKG--SIYLVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQ---R--
||.||| |.  ..|||.|||||||||||   ..||||..|| .||.| | | ||| | |||||||  |.|.|. | |||||||||||     |.   |  
ATAYNRYKDRATFYLVFDFCEHDLAGLLSNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPL

YTNRVVTLWYRPPELFLGERNYGPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKL------ELPQKENRKLKER
||||||||||||||| ||.|||||||||||||||||||||| |||||.|||.| .|| |||||| |  | ..|..| ..|.      |||.   ||.|.|
YTNRVVTLWYRPPELLLGDRNYGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLQLISQLCGSITPDVWPNCENMELWNKMSSEPNSELPKGQKRKVKDR

LRHFVE----------------------DPYALDLIDKLLMLDPRKRIDADSTLEHDFF
.. ..                       |..|..|||||| .|| ||.|.|  |.||.|
MKNYMKFDAPDSKTDPFGKNVKQHDSATDQQACHLIDKLLNIDPKKRMDSDEALDHDWF

Kinase AqueK100.AA CDK 16-234 38 6.1e-105 336.7 In-house 86-284 (284) Show / Hide
Range on Protein: 16-234
Range on HMM: 86-284/284
Sequence Identity: 38% (92 aa)

RDK--GSIYLVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGE-----LKLADFGLARALNK-----GTNQR
.||   ..|.| ....|||.....          ||..|.|| ..|.|.| |.|.|||.|  |||....||     ||.|||||||| .      . |. 
KDKHENKLYMVFEYMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRT

YTNRVVTLWYRPPELFLGERNYG--PPIDMWGAGCIMAEMWT---RRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKLELPQKENRKLKERL
||..|||||||.||| ||...|.  .|||||..|||.|||.|   |.|...||.|. |. .|...||. ..  | ||.|| .|                 
YTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------

RHFVEDPYALDLIDKLLMLDPRKRIDADSTLEHDFF
          ||..|.|..|| ||| |.  |.|..|
----------DLLNKMLCYDPKKRISAEQALQHPYF

Kinase AqueK100.AA CRK7 10-234 40 5.1e-93 315.33 In-house 75-343 (343) Show / Hide
Range on Protein: 10-234
Range on HMM: 75-343/343
Sequence Identity: 40% (108 aa)

SATPYNRDKGSIYLVLDFCEHDLAGLLECKEIK-FSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGT-NQRYTNR
.|   ...|||.|.| .   |||.|||| ||.. ||....| .| ||   ..|.| .|.|||| |  |||.  .||.|.||||||| .|.    . ||||
DASEFKKHKGSFYMVFEYMDHDLMGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNR

VVTLWYRPPELFLGERNY--------------------------------------GPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISP
|.||||||||| ||| .|                                      || ||||. |||..|  |..|| ||  | .|. .| ..|||  |
VITLWYRPPELLLGEERYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNP

TEWAGVEKLEYYQKLELPQKENRKLKERLRH----FVEDPYALDLIDKLLMLDPRKRIDADSTLEHDFF
  |  | || ... .   .. ||.| |   |       .. .||| ||.| ||| ||. |  .|.||.|
NNWPEVMKLPWWNTMKPKRQYNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF

Kinase AqueK100.AA CMGC 16-234 21 1.4e-92 304.55 In-house 108-513 (513) Show / Hide
Range on Protein: 16-234
Range on HMM: 108-513/513
Sequence Identity: 21% (87 aa)

RDKG-----------------SIYLVLDFCEHDLAGLLECKE--------IKFSLSE------------IKNIM------QQLFNALA--YIHGNN--IL
..|.                 ..||| ....|||..... .         ...|  .            ||..|      .|....|.  |.| ..  |.
YHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNII

HRDMKSCNILVTRKGEL--------------------KLADFGLARALNKGTNQR--------------------YTNRVVTLWYRPPELFLGE------
|||.|  |||.. ..||                    |..||||||....  ...                    ||..|||.|||.||. ||       
HRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNH

---RNYGPPIDMWGAGCIMAEMWTR--------RPIMQGDTE-----------QKQITLICQLCGSIS---------------PTEWAGVEKLEYYQK--
   ..|..|||||..|||.|||.|.        .|. .|..|           . |. .|....|...               . || .. || .|.|  
NYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFP

-----------------------LELPQKENRKLKERLRHFV---------------------------------EDPYALDLIDKLLMLDPRKRIDADS
                       . .|..  ...|.    .                                  .|| |.||..|.| .|| ||| |. 
KKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQ

TLEHDFF
 |.|..|
ALQHPYF

Kinase AqueK100.AA CDC2 20-234 34 2.9e-72 221.22 In-house 74-301 (301) Show / Hide
Range on Protein: 20-234
Range on HMM: 74-301/301
Sequence Identity: 34% (79 aa)

SIYLVLDFCEHDLAGLLE-CKEI--KFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRYT--NRVVTLWYR
..|.| .....||  ...  .    ..... .|..| |. ..... | . |.||| |  |||. .||..|.|||||||| .   .. ||    |||||||
KLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRT-YTTEHEVVTLWYR

PPELFLGERNYGPPIDMWGAGCIMAEM---WTRRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKL--ELPQKENRKLKER----LRHFVEDP
.||. ||.. |  |.|||  |||.|||    |..|. .|| |  |.  | .  |. .  .| ||..| .|.    .....  .|. ..    .  .  ||
APEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDP

YALDLIDKLLMLDPRKRIDADSTLEHDFF
 ..||....| .|| ||| |.. |.| .|
EGIDLLMQMLQYDPQKRISAKEALQHPYF

Kinase AqueK100.AA PITSLRE 17-234 39 4.8e-72 245.67 In-house 74-295 (295) Show / Hide
Range on Protein: 17-234
Range on HMM: 74-295/295
Sequence Identity: 39% (90 aa)

DKGSIYLVLDFCEHDLAGLLECKE---IKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTN-QRYTNRVVTLW
.. .||.|... ||||..|.|       .|...|||  |||| .. .. | | |.||| |  |.| . || ||..||||||    | .   ||  |||||
NMDKIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREY--GSPIKPYTPCVVTLW

YRPPELFLGERNYGPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISPTE--WAGVEKLEYYQKLE-LPQKENRKLKERLR--HFVEDPYA
|| ||| || . | .|.|||  |||.||. | .|..||. |  ||  | .. |   |||  | |. .|    ... .|.     |..|      . |  .
YRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMG--TPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISD-TG

LDLIDKLLMLDPRKRIDADSTLEHDFF
.||  ..| ..| .|| |.  | |..|
FDLLNQMLTYNPKNRITASDALKHPWF

Kinase AqueK100.AA MAPK 21-234 31 9.5e-63 214.78 In-house 91-328 (328) Show / Hide
Range on Protein: 21-234
Range on HMM: 91-328/328
Sequence Identity: 31% (75 aa)

IYLVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNA--LAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRY-------------T
||.| ...|.||  ....   . |   |. .| |. ..  | |||  |..||| | .||||.  ..||..|||||| .   .....             |
IYIVMELMETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMT

NRVVTLWYRPPELFLG--ERNYGPPIDMWGAGCIMAEMWT-RRPIMQGDTEQKQITLICQLCGSISPTEWAGVE-KLEYYQKLE----LPQKENRKLKER
  |.| ||| ||. |.   ..|   .||| .|||.||| | |.|. .|.  . |..|| ...|. |.  .  ..   .... ..    ||..  . ... 
EYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKM

LRHFV--EDPYALDLIDKLLMLDPRKRIDADSTLEHDFF
.   .   .| |.||..|.| .|| |||...  |.| .|
FPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF

Kinase AqueK100.AA CDK5 23-234 36 1.3e-62 196.42 In-house 75-287 (287) Show / Hide
Range on Protein: 23-234
Range on HMM: 75-287/287
Sequence Identity: 36% (79 aa)

LVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRYTNRVVTLWYRPPELFLGE
||  ||  ||   ..  . . ..  || .| ||   ||. | ...||||.|  | |. ..|||||||||||||     .  |.  |||||||||   .| 
LVFEFCDQDLKKYMDSCNGEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC-YSHEVVTLWYRPPDVLMGS

RNYGPPIDMWGAGCIMAEMW-TRRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQ--KLELPQKENRK-LKERLRHFVEDPYALDLIDKLLMLD
. |  .|||| .|||.|||  . ||   |  .. |  .| .. |. .  .| .. ||  |.    ..|  . .. ...  ..   |   .||  |.|...
KHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK--LDEKGMDLLQKMLQCN

PRKRIDADSTLEHDFF
| .||.|.  |.| .|
PNQRISAKAALHHPYF

Kinase AqueK100.AA Pkinase 16-234 30 4.9e-60 210.55 Pfam 70-293 (293) Show / Hide
Range on Protein: 16-234
Range on HMM: 70-293/293
Sequence Identity: 30% (72 aa)

RDKGSIYLVLDFCEH-----DLAGLLE-CKEIKF--SLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGEL----KLADFGLARALNKGTNQR
.||..||.|...||.     ||. ...  .. .|  |  |.|..| |.. .|.|.| ..|.|||.|. |||. ..|..    |..|||||. ..   |. 
EDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-

YTNRVVTLWYRPPELFLGERNYGPPIDMWGAGCIMAEMWTRRPIMQGD----TEQKQITLICQLCGSISPTEWAGVEKLEYYQKLELPQKENRKLKERLR
.| ...|.||..||. .| . |||..|||..|||..|| ..||. .|.    .   |. .||.  | . . .|       |.  .   . .     ....
MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF

HFVEDPYALDLIDKLLMLDPRKRIDADSTLEHDFF
    .. ..|.|...| .|| ||. |.  |.|..|
-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase AqueK100.AA CDK10 20-234 39 2.9e-59 203.19 In-house 74-285 (285) Show / Hide
Range on Protein: 20-234
Range on HMM: 74-285/285
Sequence Identity: 39% (85 aa)

SIYLVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRYTNRVVTLWYRPPELF
||.||...|| ||| ||.     |. ...| || |.  .| |.| | ..|||.|  |.|.| || .|.|||||||.      .  | ..|||||| ||| 
SIFLVMQYCEQDLASLLDNMPQPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPV-KPMTPKMVTLWYRAPELL

LGERNYGPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKLELPQKENRKLKERLRHFVEDPYALDLIDKLLMLDP
|| |.    |||| .|||..|.   .|.| |  | .|| .| .| |. | . | |  .|   |.  | ..    ||..     .    . |.. |.| .|
LGCRTQTTAIDMWAVGCILGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQS--GRRLLNFLFMYNP

RKRIDADSTLEHDFF
.||  |. .||  .|
KKRATAEECLESSYF

Kinase AqueK100.AA CDK-DD1 23-191 40 5.7e-54 164.74 In-house 75-248 (379) Show / Hide
Range on Protein: 23-191
Range on HMM: 75-248/379
Sequence Identity: 40% (72 aa)

LVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRYTNRVVTLWYRPPELFLGE
.|. . |||| ...  .    ||. ||. . ||   .  .| . | ||| |  | |.. .| ||..|||..    |        .||.|||||||| .| 
MVFEYFEHDLWKFMSNHQCYMSLPCIKCFFHQLLEGINECHNQGIMHRDIKPANLLINNRGDLKITDFGFTTYYTKRSEKHFSHQVVSLWYRPPELLMGS

RNYGPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISPTE--WAGVEKLE-YYQKLELP----QKEN
..||| ||||  |||. || | . .. |  || |  ||| |||   |||  | || .|  | | . ..    | ||
CQYGPEIDMWSVGCILMEMITNFYMFAGSNEQQQLELICKLCG--CPTEKNWPGVSQLQGYNQYFHKQQQQQQNEN

S_TKc AqueK100.AA S_TKc 4-234 22 5e-41 143.53 SMART 14-231 (231) Show / Hide
Range on Protein: 4-234
Range on HMM: 14-231/231
Sequence Identity: 22% (62 aa)

QVLLFLSAT--------------------------------PYNRDKGSIYLVLDFCEH---DLAGLLECKEIK-----FSLSEIKNIMQQLFNALAYIH
.| .                                      . .| ...|.|...|..   ||  ... .  .     |.  ... .|.|...||.|.|
KVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCH

GNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRYTNRVVTLWYRPPELFLGERNYGP-PIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQ
 ..|.||| |  |||...  ..|..|||||| |        |  ..|.||..||..     ||. ..|.|  |||..|| ...|  .      |. .. .
SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFK

LCGSISPTEWAGVEKLEYYQKLELPQKENRKLKERLRHFVEDPYALDLIDKLLMLDPRKRIDADSTLE-------HDFF
..|                                      .| |.|.|.|.|  ||.||. |   |.       | .|
KIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK100.AA CDK-DD1 192-234 41 7.9e-11 29.04 In-house 337-379 (379) Show / Hide
Range on Protein: 192-234
Range on HMM: 337-379/379
Sequence Identity: 41% (18 aa)

RKLKERLRHFVEDPYALDLIDKLLMLDPRKRIDADSTLEHDFF
.|| ..  | |  |  |||| ..| |.| ||| .   |.| .|
KKLIDKFPHLVLLPSFLDLIERMLTLCPKKRINTKEALQHPWF

Kinase AqueK100.AA Pkinase_Tyr 16-100 27 1.8e-07 25.94 Pfam 75-166 (270) Show / Hide
Range on Protein: 16-100
Range on HMM: 75-166/270
Sequence Identity: 27% (25 aa)

RDKGS--IYLVLDFCEH-DLAGLLECK---EIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARAL-NKGT
.....  ||.|. ...| ||   |  .   . ....... .. .|  ....| . .|. |||    |.|||...  | .||||||.. |...
DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDY

TyrKc AqueK100.AA TyrKc 1-167 13 0.000244 -152.47 SMART 1-280 (280) Show / Hide
Range on Protein: 1-167
Range on HMM: 1-280/280
Sequence Identity: 13% (37 aa)

MHLQVLL-----------------------------------FLSAT-PYN----------RDK-------GSIYLVLDFCEH-DLAGLLECKEIKFSLS
 .|   |                                    ..   . .          ...       . ...|. ...| ||   |  .. |....
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

EIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKG-----TNQRYT-----NRV--VTLWYRPPELF---------------
.  ... |  .  .|.| .|. |||    |.||....  | .||||.|..  .       . |.     ..   . .   .|| .               
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG

--------LGERNYGPPIDMWGAGCIMAEMWT------RRPIMQG---------DTEQKQITLIC------------QLCGSI
        .|.  |  .| .    .  .|.        |.|...           .|  || . |            ...  .
VCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF