AqueK119

Species: A.queenslandica
Alias: AqueK119
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
AqueK119.AA Protein None 743 None Fasta, JSON
AqueK119.kin_dom Protein Kinase Domain None 301 None Fasta, JSON

Protein domain

Protein domains of AqueK119.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK119.AA ERK1 29-329 35 2.8e-58 199.95 In-house 1-289 (289) Show / Hide
Range on Protein: 29-329
Range on HMM: 1-289/289
Sequence Identity: 35% (109 aa)

YKDLEYLALGGNGLVCKAIDTYTDKRVVISKRDSLFSKTYCQRDLRELQVISRLQKALGDDLPIPELIDIVCEPANQPIGEGTKFYVVQEAKEGTIEIIL
| .|.|.. |  |.|| |.|| . .|| | |      .||||| |||.... | .        | .. ||.  ..   | .    |.||.  |  .  .|
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHEN-----IINIQDIIRADT---IEQMRDVYIVQCLMETDLYKLL

QADQLPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLAAVNGIESDPNFELLRFTDSYRVEHLHYWAPEVLINEE-ITPVVD
.. .| | . .   .||.|| ||  ||| ..|| ..   .|.   |||..||| || .    .||. .   |   | |    | |||...|    |  .|
KTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARI----ADPEHDHTGFLTEY-VATRWYRAPEIMLNSKGYTKSID

IWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSV-QNSSPTFEERFKNIDPVARDLLKKMLVFNPSQRITAEKALEH
||| ||| ||.|  . .|       || .|. .||.|| .||  .  .  |  | |.   .   ... | . |. | ||| ||| ||| .||| |.|| |
IWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAH

EYL
 ||
PYL

Kinase AqueK119.AA CMGC 29-329 19 9.5e-58 187.92 In-house 1-513 (513) Show / Hide
Range on Protein: 29-329
Range on HMM: 1-513/513
Sequence Identity: 19% (102 aa)

YKDLEYLALGGNGLVCKAID--------------TYTDKRVVISKRDSLFSKTYCQ----------RDLRELQVISRLQ-----------KALGDDLP-I
|. ....  |  | |.|..|              . |...| | |  . | .. ..          | |||..   .|.           .  ... . |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

PELIDIVCEPANQPIGE---------GTKFYVVQEAKEGTIEIILQADQ---------LPSPEQ------------VKILM------YQLLRALK--LFH
  |.||.  . ... ..           ..| | |  . .   ...  |           |. .            .| .|      ||.||.||    |
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SAG--IIHRCIRSNDILIDADCDL--------------------RVCDFRLAAVNGIESDPNFELLRF-------------TDSYRVEHLHYWAPEVLIN
|..  |||| .    |||. .|.|                    ..||| ||   ...||..|.  ..             . . .|  ..| |||.|..
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

EE----------ITPVVDIWSAGCIFAELLTG--------KKVFGSSDV-----------RGQLDLIVDLLGAPS---------------PEDLAFVKG-
 .           |. .|.||.||||||..||        |  |  ..              ||..|...|| |.               .|.   ... 
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

--------------------DASRTALTS----VQNSSPTFEERFKN-----------------------------------IDPVARDLLKKMLVFNPS
                    .  |... |     .   ..... |..                                   .|| |.|||||||...|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRITAEKALEHEYL
.||||| ||.|.|.
KRITAEQALQHPYF

Kinase AqueK119.AA nmo 114-329 35 1.1e-49 150.68 In-house 79-292 (292) Show / Hide
Range on Protein: 114-329
Range on HMM: 79-292/292
Sequence Identity: 35% (79 aa)

YVVQEAKEGTIEIILQADQLPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLAAVNGIESDPNFELLRFTDSYRVEHLHYWA
||| |     .  |. . |  |.. ||. .||.|| ||  |||.|.|| |.  ..|....| |..||| || |   .   .      |  ||       |
YVVTELMQSDLHKIIVSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYR-------A

PEVLI-NEEITPVVDIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSVQNSSPTFEERFKNID-----PVARDLLK
||.|.     |  ||||| ||||||||  . .|       ||..|.|||| || ||. .   .  .. .       | ..  ..          | .||.
PEILMGARHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYA-CEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLC

KMLVFNPSQRITAEKALEHEYL
.||.|.|..|| .. ||.| ||
RMLHFDPDKRISCKDALAHPYL

Kinase AqueK119.AA ERK5 29-329 31 2.7e-47 163.45 In-house 1-295 (295) Show / Hide
Range on Protein: 29-329
Range on HMM: 1-295/295
Sequence Identity: 31% (96 aa)

YKDLEYLALGGNGLVCKAIDTYTDKRVVISKRDSLFSK-TYCQRDLRELQVISRLQKALGDDLPIPELIDIVCEPANQPIGEGTKFYVVQEAKEGTIEII
|| .| .  |  | || |.   . ..| | |    | . |  .| .|||...   .        |  . ||.     .|..|    ||| .  |  .  |
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDN-----IIAIRDILM--PKVPYSEMKDVYVVFDLMESDLHQI

LQADQLPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLAAVNGIESDPNFELLRFTDSYRVEHLHYWAPEVLI-NEEITPVV
. ..|  . | ..  .||.|| ||  ||| .||| ..   .|.   |.|.. || .|   |.      .   |  .| |    | |||...  .. |  .
IHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMAR--GLCTFSPDKHQMFMTEY-VATRWYRAPELMFSSHDYTQAI

DIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTS-VQNSSPT-FEERFKNIDPVARDLLKKMLVFNPSQRITAEKAL
|.|| |||| |... ...|       ||.||.. || |.|  .  |  |  .  . . . |  |  .|. .   |. | ||| .||.| ||.|||. |||
DVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKAL

EHEYL
 | .|
QHPFL

Kinase AqueK119.AA ERK7 139-329 36 8.8e-45 150.92 In-house 102-292 (292) Show / Hide
Range on Protein: 139-329
Range on HMM: 102-292/292
Sequence Identity: 36% (71 aa)

VKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLAAVNGIESDPNFELLRFTDSYRVEHLHYWAPEVLIN-EEITPVVDIWSAGCIFAE
..  |||||||.|  ||. .||| ..   ||.|..| ..|||| ||   .   . . .    |. | |    | |||.|.  .. |. || || ||| .|
KQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTE-Y-VATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

LLTGKKVF-GSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSVQNSSP-TFEERFKNIDPVARDLLKKMLVFNPSQRITAEKALEHEYL
.|.|| .| |.| .  |...|..... |. ||.. .. . . . | ... . . |... ...  . | ||||..||||| .|.|||.||.| | 
MLRGKPMFPGTSTMN-QIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV

Kinase AqueK119.AA MAPK 213-329 40 2.3e-44 151.23 In-house 199-328 (328) Show / Hide
Range on Protein: 213-329
Range on HMM: 199-328/328
Sequence Identity: 40% (52 aa)

APEVLIN---EEITPVVDIWSAGCIFAELLT-GKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVK-GDASRTALTSV---QNSSP-TFEERFKN----ID
|||.. |    . |  ||.||.||||||.|| .|  |  .|   |. ||...|| ||.|.. ...  .. |. . |    ..  . ..|. |.|     .
APEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

PVARDLLKKMLVFNPSQRITAEKALEHEYL
| |.|||.|||||.|..|||.| ||.|.|.
PQAIDLLEKMLVFDPDKRITVEEALQHPYF

Kinase AqueK119.AA S_TKc 29-329 21 1.4e-34 122.07 SMART 1-231 (231) Show / Hide
Range on Protein: 29-329
Range on HMM: 1-231/231
Sequence Identity: 21% (69 aa)

YKDLEYLALGGNGLVCKAIDTYTDKRVVISKRDSLFSKTYCQRDLRELQVISRLQKALGDDLPIPELIDIVCEPANQPIGEGTKFYVVQEAKEG---TIE
|. |. .  |. | |.|.... |...| | . .        .. .||.|. ..      .   |  |.|.  .         ...|.| |  .|   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK------HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLF

IILQADQLP------SPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLAAVNGIESDPNFELLRFTDSYRVEHLHYWAPEVLIN
 ...  . .      .. ... .|||...||.  || ||||| .    ||.|    . .||| ||..                .  .  ..| |||||  
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL--

EEITP-VVDIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSVQNSSPTFEERFKNIDPVARDLLKKMLVFNPSQRI
   ..  .|.|| |||..|.|.|.  |       |.... ...|                                    .| |.|...|.|...|..|.
-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRP

TAEKALE-------HEYL
|| .||.       |...
TA-EALQDEWDIKCHPWF

Kinase AqueK119.AA ERK 226-329 41 6e-33 115.78 In-house 198-307 (307) Show / Hide
Range on Protein: 226-329
Range on HMM: 198-307/307
Sequence Identity: 41% (46 aa)

VDIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAP-SPEDLAFVKGDASRTALTSVQN--SSPT-FEERFKN--IDPVARDLLKKMLVFNPSQRIT
.||||.||||||.| .| .|   | ..|...| ...| | | |||   . .  .  ... .|    |  .|..|.|  . | | |||.|||||.|..|||
MDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRIT

AEKALEHEYL
.| .|||.|.
VEECLEHPYF

Kinase AqueK119.AA p38 211-329 40 5.3e-32 106.47 In-house 169-289 (289) Show / Hide
Range on Protein: 211-329
Range on HMM: 169-289/289
Sequence Identity: 40% (49 aa)

YWAPEVLINE-EITPVVDIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSV-QNSSPTFEERFKNIDPVARDLLKK
| |||.. |  . |  ||||| ||| |||.||.  |  .|   ||  |. ..| |..| .. .. ...|. . |  |     |.. |.. .| | ||| |
YRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEK

MLVFNPSQRITAEKALEHEYL
||.  | .||||| |..|.|.
MLELDPDKRITAEEAMQHPYF

Kinase AqueK119.AA Pkinase 209-329 26 1.2e-26 95.24 Pfam 175-293 (293) Show / Hide
Range on Protein: 209-329
Range on HMM: 175-293/293
Sequence Identity: 26% (33 aa)

LHYWAPEVLI-NEEITPVVDIWSAGCIFAELLTGKKVFGSS----DVRGQLDLIVDLLGAPSPEDLAFVKGDASRTALTSVQNSSPTFEERFKNIDPVAR
..| ||||.  .....| ||.||.|||..|.|.|.  | ..    . . |. .|.  .|.| ..|         .. ..  . . . .... .|... ..
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECK

DLLKKMLVFNPSQRITAEKALEHEYL
|..|..| ..|..|.||| .|.|...
DFIKWCLCKDPKKRPTAEQILQHPWF

Kinase AqueK119.AA MAPK-Unclassified 209-329 29 4.6e-26 90.9 In-house 412-575 (575) Show / Hide
Range on Protein: 209-329
Range on HMM: 412-575/575
Sequence Identity: 29% (49 aa)

LHYWAPEV-LINEEITPVVDIWSAGCIFAELLTG-----------KKVFGSSD--------------------VRGQLDLIVDLLGAPSPEDLAFVKGDA
. | |||  | . | .  |||||.||||||..             .  |  .|                    . .|. .|.| || |  ||. |.. | 
RWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDS

SRTALTSV-QNSSPTFE-ERFKNID---------PVARDLLKKMLVFNPSQRITAEKALEHEYL
 |  . |  .  .  |    | .           . ..|...|||.|||. ||||. ||||.| 
ARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF

Kinase AqueK119.AA p38 29-184 34 1.6e-17 56.22 In-house 1-153 (289) Show / Hide
Range on Protein: 29-184
Range on HMM: 1-153/289
Sequence Identity: 34% (55 aa)

YKDLEYLALGGNGLVCKAIDTYTDKR---VVISK-RDSLFSKTYCQRDLRELQVISRLQKALGDDLPIPELIDIVCEPANQPIGEGTKFYVVQEAKEGTI
|..|...  |  | ||||.|. |...   | | | .   .|  .  |  |||    || | .  .  | .|.| |  |... . . . .|.| .  .   
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYREL----RLLKHMRHENVI-CLLD-VFTPPAHSMNDFQDVYMVTHFMGADL

EIILQADQLPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLA
. |.   .| | .....| ||.||.||  ||||||||      | .  ||.||. || ||
NNIMKCQRL-SDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLA

Kinase AqueK119.AA MAPK 135-184 46 9.5e-14 43.7 In-house 113-164 (328) Show / Hide
Range on Protein: 135-184
Range on HMM: 113-164/328
Sequence Identity: 46% (24 aa)

SPEQVKILMYQLLRA--LKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLA
| . .. .|||.||.  ||  |||..||| .    ||.. .|||..||| ||
SDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLA

Kinase AqueK119.AA ERK3 297-329 54 4.3e-13 38.07 In-house 268-300 (300) Show / Hide
Range on Protein: 297-329
Range on HMM: 268-300/300
Sequence Identity: 54% (18 aa)

NIDPVARDLLKKMLVFNPSQRITAEKALEHEYL
|||  | |.| .|| |.|. |.||| ||.| |.
NIDCHALDFLEQMLTFDPMDRLTAEMALQHPYM

Kinase AqueK119.AA MAPK-Unclassified 127-184 38 3.1e-11 36.37 In-house 98-156 (575) Show / Hide
Range on Protein: 127-184
Range on HMM: 98-156/575
Sequence Identity: 38% (23 aa)

ILQADQ-LPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLA
|.. .|   . .......||.|| ||  |||.||||      .||. || .|.||| ..
IIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMS

Kinase AqueK119.AA ERK 142-184 51 3e-10 34.54 In-house 113-155 (307) Show / Hide
Range on Protein: 142-184
Range on HMM: 113-155/307
Sequence Identity: 51% (22 aa)

LMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDLRVCDFRLA
.|||.|..||  |||..||| ..   ||.  .||| .||| ||
FMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLA

Kinase AqueK119.AA ERK3 29-83 41 6.5e-10 27.68 In-house 1-54 (300) Show / Hide
Range on Protein: 29-83
Range on HMM: 1-54/300
Sequence Identity: 41% (23 aa)

YKDLEYLALGGNGLVCKAIDTYTDKRVVISKRDSLFSKTYCQRDLRELQVISRLQ
. ||  |  |.||||  |.|   .|.| | |. .|  |  |   ||| ..| ||.
FCDLRPLGCGSNGLVFSAVDSECCKKVAI-KKIVLTDKKSCKHALREIKIIRRLD

Kinase AqueK119.AA ERK3 114-184 37 6.7e-10 27.64 In-house 88-158 (300) Show / Hide
Range on Protein: 114-184
Range on HMM: 88-158/300
Sequence Identity: 37% (27 aa)

YVVQEAKEGTIEIILQADQLPSPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDA-DCDLRVCDFRLA
..|||  |     ..   .| | | ..  |||||| ||  ||| . ||  .   |.|   |  |.. || .|
CIVQEYMETDLACVMEQQRL-SEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMA

Kinase AqueK119.AA ERK3 226-245 65 3.1e-09 25.47 In-house 196-215 (300) Show / Hide
Range on Protein: 226-245
Range on HMM: 196-215/300
Sequence Identity: 65% (13 aa)

VDIWSAGCIFAELLTGKKVF
.|.|.||||.||.||||  |
IDMWAAGCILAEMLTGKMLF

Kinase AqueK119.AA MAPK 29-76 32 2.6e-08 24.63 In-house 1-55 (328) Show / Hide
Range on Protein: 29-76
Range on HMM: 1-55/328
Sequence Identity: 32% (18 aa)

YKDLEYLALGGNGLVCKAIDTY------TDKRVVISKR-DSLFSKTYCQRDLREL
|..|...  |  |.||.|||.       ..|.|.| |  .   ..|.|.| .||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREI

Kinase AqueK119.AA MAPK-Unclassified 29-78 32 0.000623 9.5 In-house 1-52 (575) Show / Hide
Range on Protein: 29-78
Range on HMM: 1-52/575
Sequence Identity: 32% (17 aa)

YKDLEYLALGGNGLVCKAIDTYT-DKRVVISKRDSLFS-KTYCQRDLRELQV
|   ...  |. | ||.|.|. .  . | | |   .|  .| | | |||. .
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRI

Kinase AqueK119.AA Pkinase 135-181 43 0.002031 13.17 Pfam 106-156 (293) Show / Hide
Range on Protein: 135-181
Range on HMM: 106-156/293
Sequence Identity: 43% (22 aa)

SPEQVKILMYQLLRALKLFHSAGIIHRCIRSNDILIDADCDL----RVCDF
|....|  |||.||.|.  || ||||| . .  |||| ....    ..|||
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF

Kinase AqueK119.AA ERK 29-76 35 0.002948 8.21 In-house 1-54 (307) Show / Hide
Range on Protein: 29-76
Range on HMM: 1-54/307
Sequence Identity: 35% (19 aa)

YKDLEYLALGGNGLVCKAIDTY-----TDKRVVISKRDSLFSKT-YCQRDLREL
|.... .  |. |.||.|||.      |...| | |    |... || | |||.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREI

Kinase AqueK119.AA Pkinase 29-57 27 3.925828 1.55 Pfam 1-29 (293) Show / Hide
Range on Protein: 29-57
Range on HMM: 1-29/293
Sequence Identity: 27% (8 aa)

YKDLEYLALGGNGLVCKAIDTYTDKRVVI
|. .. .  |. | |.|...  | |.|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAV

Kinase AqueK119.AA ERK7 509-698 33 9.3e-33 109.13 In-house 104-292 (292) Show / Hide
Range on Protein: 509-698
Range on HMM: 104-292/292
Sequence Identity: 33% (65 aa)

CLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD--LRRSLMNHEPCGEEYNWTGSSTEGSWQYLSPQA-VCYDEQTTACDLWSAGCVFGEMLL
. || ||  .| .||. |.|| |.|  .|| ||  . .||  | ||. . |  .|.           | | .|   .   . | . |.|| ||. |||| 
YIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRW-YRAPEILLGSHRYTKGVDMWSIGCILGEMLR

GQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSPAKRLTAEEALKHPYF
|.|.|        . ..|  |...|. .... . | .. ..|.... ..  .||  ...   |.  .||||..|.| | ||||||.||.||| 
GKPMFPGTSTMNQIEKIL-ETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDA--IDLLKRLLVFNPKKRLTAEQALQHPYV

Kinase AqueK119.AA CMGC 584-698 21 5e-32 101.81 In-house 303-513 (513) Show / Hide
Range on Protein: 584-698
Range on HMM: 303-513/513
Sequence Identity: 21% (46 aa)

YDEQ------TTACDLWSAGCVFGEMLLG--------QPLFVSDANA----------VNLFRVLFSTLGRPK---------------DQELAFVTS----
|...      ||..| ||.||.|.||..|        .|||  . .           ..     | .|| |                ..|   ...    
YTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWY

-------------------------------RLGLQVLKELKLNESPSLDSNLRK------------------------RNVDGQVLDLLKKMLAFSPAK
                               .   . .|.|. . ..  | | .|                        .. | | .||||||| . |.|
NKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDK

RLTAEEALKHPYF
|.|||.||.||||
RITAEQALQHPYF

Kinase AqueK119.AA MAPK 588-698 33 5.2e-30 100.82 In-house 212-328 (328) Show / Hide
Range on Protein: 588-698
Range on HMM: 212-328/328
Sequence Identity: 33% (40 aa)

TTACDLWSAGCVFGEMLL-GQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVT-SRLGLQVLKEL---KLNESPSLDSNLRKRN--VDGQVLDLLKKMLA
|.| | ||.|| |.|||  ..|||    . .. .   ...|| |... . ... |    .... |   .     .... . . |  .. | .|||.|||.
TKAVDMWSVGCIFAEMLTDRKPLFP-GKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLV

FSPAKRLTAEEALKHPYF
|.| ||.|.|||| ||||
FDPDKRITVEEALQHPYF

S_TKc AqueK119.AA S_TKc 397-698 20 4.1e-23 84.04 SMART 1-231 (231) Show / Hide
Range on Protein: 397-698
Range on HMM: 1-231/231
Sequence Identity: 20% (66 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRVVLSKRDGLYSQEYSKRNLRELQLLTRLQRMYSDDYDPFPRLLDFLCYPQNLSGPKQAELYVVQTAFDV---NL
|. |. . ||. |. . .....|  .| . . .        .. .||.|.| .            | .  .. . |.       .||.|    |    .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK----------HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDL

ADLLNQQR-------MTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD--LRRSLMNHEPCGEEYNWTGSSTEGSWQYLSPQAVCY
 |.. ...       ..  . ...|| ..  |. .|| |..|| | |  .||..   . .||  | | |              ..  |.  |..|  .  
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--

DEQTT-ACDLWSAGCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSP
   .. .|| || ||.. ||| |.|.|    .   .|...                                            . ...|...|.| . |
-GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------------------------------------SPEAKDFIRKCLQKDP

AKRLTAEEALK-------HPYF
.||.|| |||.       ||.|
EKRPTA-EALQDEWDIKCHPWF

Kinase AqueK119.AA MAPK-Unclassified 588-698 24 5.2e-22 76.01 In-house 427-575 (575) Show / Hide
Range on Protein: 588-698
Range on HMM: 427-575/575
Sequence Identity: 24% (37 aa)

TTACDLWSAGCVFGEMLLG-----------QPLFVSDA---------NAVN----------LFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPS
.|. |.||.||.|.||..            .|||  .          | |.             ..|. ||.|. . . |.|.    . .. .|   .  
DTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDSARKYIQSFKCKTPVH

LDSNLRKRNV--------DGQVLDLLKKMLAFSPAKRLTAEEALKHPYF
 ..     .         . . .|...|||.|.| || ||..||.||||
FTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF

Kinase AqueK119.AA ERK5 511-698 30 6.4e-22 76.97 In-house 109-295 (295) Show / Hide
Range on Protein: 511-698
Range on HMM: 109-295/295
Sequence Identity: 30% (58 aa)

MYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD--LRRSLMNHEPCGEEYNWTGSSTEGSWQYLSPQAV-CYDEQTTACDLWSAGCVFGEMLLGQ
.| .|  || .||| |.|| |.|  ||     .| . |  . | |    |  ...  | .     | |  |  .   .. | | |.|| ||.||||.  .
LYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMT-EYVATRW-YRAPELMFSSHDYTQAIDVWSVGCIFGEMIARR

PLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSPAKRLTAEEALKHPYF
 .|    | ..  ...   || |  . .  | .      ...   |  |   . .  .  | | |||| .|| | |..|.|. .||.||. 
QMFPG-KNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPK-ADRQALDLLARMLRFEPSERITVNKALQHPFL

Kinase AqueK119.AA ERK 588-698 36 7.6e-21 74.46 In-house 195-307 (307) Show / Hide
Range on Protein: 588-698
Range on HMM: 195-307/307
Sequence Identity: 36% (42 aa)

TTACDLWSAGCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRP-KDQELAFVTSRLGLQVLKELKL--NESPSLDSNLRKRNVDGQVLDLLKKMLAFSPA
|.| | ||.|| | ||| ..|||   .. |. ..  |...| |  ...|   .|   .. .|.|     .  .. .   . |.  | .|||.|||.| | 
TKAMDIWSCGCIFAEMLGRKPLFP-GKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPD

KRLTAEEALKHPYF
||.|.||.|.||||
KRITVEECLEHPYF

Kinase AqueK119.AA Pkinase 588-698 25 1.9e-17 62.74 Pfam 190-293 (293) Show / Hide
Range on Protein: 588-698
Range on HMM: 190-293/293
Sequence Identity: 25% (29 aa)

TTACDLWSAGCVFGEMLLGQPLFVSDA----NAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSP
....| ||.||.. |||.|.|.|  ..    | ..   ... ..|.| . .     |.     ..  .          ..  |..   .|..|..|.. |
GPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDP

AKRLTAEEALKHPYF
.||.|||..|.||.|
KKRPTAEQILQHPWF

Kinase AqueK119.AA ERK3 666-698 57 7.9e-17 50.32 In-house 268-300 (300) Show / Hide
Range on Protein: 666-698
Range on HMM: 268-300/300
Sequence Identity: 57% (19 aa)

NVDGQVLDLLKKMLAFSPAKRLTAEEALKHPYF
|.|   ||.| .|| |.|  |||||.||.|||.
NIDCHALDFLEQMLTFDPMDRLTAEMALQHPYM

Kinase AqueK119.AA p38 588-698 29 7.9e-16 50.32 In-house 182-289 (289) Show / Hide
Range on Protein: 588-698
Range on HMM: 182-289/289
Sequence Identity: 29% (33 aa)

TTACDLWSAGCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSPAKRL
| . | || ||.  |.. |..||  | . ..  . . . .| |..  .. . |     ... .   .   . . ... |.    .||| |||   | ||.
TQTVDIWSVGCIMAELITGRTLFPGD-DHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQA--IDLLEKMLELDPDKRI

TAEEALKHPYF
|||||..||||
TAEEAMQHPYF

Kinase AqueK119.AA nmo 588-698 26 4.7e-15 42.15 In-house 182-292 (292) Show / Hide
Range on Protein: 588-698
Range on HMM: 182-292/292
Sequence Identity: 26% (30 aa)

TTACDLWSAGCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRK-RNVDGQVLDLLKKMLAFSPAKR
| | |.|| ||.|.|.|  . ||   .. ..   ..   || |   .. .        .|.. . . . .   .|    .      .||..|| | | ||
TSAVDIWSVGCIFAELLGRRILFQA-QSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKR

LTAEEALKHPYF
. ...||.||| 
ISCKDALAHPYL

Kinase AqueK119.AA ERK1 588-698 36 1.5e-14 50.91 In-house 182-289 (289) Show / Hide
Range on Protein: 588-698
Range on HMM: 182-289/289
Sequence Identity: 36% (40 aa)

TTACDLWSAGCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESPSLDSNLRKRNVDGQVLDLLKKMLAFSPAKRL
| . |.|| ||.  |||   |.|        |  .| . || |  ..|  .  .   . |. |   .  ....   |   | . |||| |||.| | ||.
TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL-GVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPK--ADSKALDLLDKMLTFNPHKRI

TAEEALKHPYF
| |||| ||| 
TVEEALAHPYL

Kinase AqueK119.AA CMGC 397-548 15 1.8e-11 32.99 In-house 1-247 (513) Show / Hide
Range on Protein: 397-548
Range on HMM: 1-247/513
Sequence Identity: 15% (38 aa)

YRNLEFLTKGSNGSMCFATDTRTSSR--------------VVLSK--RDGLYSQEYSK----------RNLRELQLLTRLQRM----------YSDDYDP
| ... . .|. |  . ..|.||  .              | . |  .     .|  |          | |||...| .|..            ... ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAI-KKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

-FPRLLDFLCYPQ-NLSGPK--------QAELYVVQTAFDVNLADLLNQQR----------MTHDQ------------LWCLM------YSLLVSLK--L
   .|.|.. ... . ....          .|| |    | .|.... ...          ... .              ..|      | .| .||   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSAG--VVHRCLRPRHLLLTSE--------------------FDLALCD
.||..  ..|| | |  .|....                    . | .||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICD

Kinase AqueK119.AA ERK3 482-546 38 3.4e-11 31.89 In-house 87-150 (300) Show / Hide
Range on Protein: 482-546
Range on HMM: 87-150/300
Sequence Identity: 38% (25 aa)

LYVVQTAFDVNLADLLNQQRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLAL
...||   .  || .. |||.. .     || ||  || .||| | || |.|  ..   | || |
VCIVQEYMETDLACVMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTE-DLVL

Kinase AqueK119.AA ERK1 481-548 39 1.5e-10 35.78 In-house 76-143 (289) Show / Hide
Range on Protein: 481-548
Range on HMM: 76-143/289
Sequence Identity: 39% (27 aa)

ELYVVQTAFDVNLADLLNQQRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD
..|.||   .  |  ||  |..  | .   .| .|  || .||| |.|| |.|  |||    || .||
DVYIVQCLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICD

Kinase AqueK119.AA p38 481-533 35 2.3e-09 27.84 In-house 82-134 (289) Show / Hide
Range on Protein: 481-533
Range on HMM: 82-134/289
Sequence Identity: 35% (19 aa)

ELYVVQTAFDVNLADLLNQQRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRP
. |.| .  .  |  .. .||.. |.   | | .|  ||  ||||..|| | |
DVYMVTHFMGADLNNIMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKP

Kinase AqueK119.AA ERK3 588-610 56 6.9e-09 24.33 In-house 193-215 (300) Show / Hide
Range on Protein: 588-610
Range on HMM: 193-215/300
Sequence Identity: 56% (13 aa)

TTACDLWSAGCVFGEMLLGQPLF
| | |.|.|||.. ||| |..||
TKAIDMWAAGCILAEMLTGKMLF

Kinase AqueK119.AA nmo 500-548 38 3.6e-08 20.57 In-house 97-145 (292) Show / Hide
Range on Protein: 500-548
Range on HMM: 97-145/292
Sequence Identity: 38% (19 aa)

QRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD
| .. | .   .| .|  || ||||...|| ..|  ||. |.  | .||
QHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICD

Kinase AqueK119.AA ERK1 397-451 38 4.8e-08 26.26 In-house 1-55 (289) Show / Hide
Range on Protein: 397-451
Range on HMM: 1-55/289
Sequence Identity: 38% (21 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRVVLSKRDGLYSQEYSKRNLRELQLLTRLQ
| ||... .|  | .| | ||..  || . |      | | .| |||...||| .
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFK

Kinase AqueK119.AA MAPK 481-548 32 2e-06 17.92 In-house 90-160 (328) Show / Hide
Range on Protein: 481-548
Range on HMM: 90-160/328
Sequence Identity: 32% (23 aa)

ELYVVQTAFDVNLADLLNQQR-MTHDQLWCLMYSLLVS--LKLLHSAGVVHRCLRPRHLLLTSEFDLALCD
..|.|.   . .|  ....|. ...|    .|| .|    || .|||.|.|| | |  .|.... || .||
DIYIVMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICD

Kinase AqueK119.AA p38 397-451 33 3.7e-05 13.25 In-house 1-59 (289) Show / Hide
Range on Protein: 397-451
Range on HMM: 1-59/289
Sequence Identity: 33% (20 aa)

YRNLEFLTKGSNGSMCFATDTRTSSR---VVLSK-RDGLYSQEYSKRNLRELQLLTRLQ
|.||... .|. |. | | |.||. .   |   | .    | .. ||  ||| ||  ..
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMR

Kinase AqueK119.AA ERK 518-549 50 6.1e-05 14.55 In-house 121-152 (307) Show / Hide
Range on Protein: 518-549
Range on HMM: 121-152/307
Sequence Identity: 50% (16 aa)

LKLLHSAGVVHRCLRPRHLLLTSEFDLALCDL
|| .|||.|.|| |.|. .|..|  ||  ||.
LKYIHSANVIHRDLKPSNILVNSNCDLKICDF

Kinase AqueK119.AA MAPK 397-451 26 0.000335 10.17 In-house 1-63 (328) Show / Hide
Range on Protein: 397-451
Range on HMM: 1-63/328
Sequence Identity: 26% (17 aa)

YRNLEFLTKGSNGSMCFATDTRTSSR------VVLSKR-DGLYSQEYSKRNLRELQLLTRL-Q
|..|... .|. |  | |.|.||. .      |.. |  .   .. . || .||. || .. .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHH

Kinase AqueK119.AA MAPK-Unclassified 498-548 37 0.001345 8.27 In-house 102-152 (575) Show / Hide
Range on Protein: 498-548
Range on HMM: 102-152/575
Sequence Identity: 37% (19 aa)

NQQRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHLLLTSEFDLALCD
||    | .   ..| .|  || ||||...|| | |  ||..    .  ||
NQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICD

Kinase AqueK119.AA Pkinase 397-529 19 0.002283 12.99 Pfam 1-132 (293) Show / Hide
Range on Protein: 397-529
Range on HMM: 1-132/293
Sequence Identity: 19% (28 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRV---VLSKRDGLYSQEYSKRNLRELQLLTRLQRMYSDDYDPFPRLLDFLCYPQNLSGPKQAELYVVQTAFDV--
|. .. . .|| |. . ...  |. .|   ...||.   ......|.|.|.|.. ||.          |  . .... ..       ..|.|.   .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---------HPNIVRLYDWFED-----KDHIYMVMEYCEGGL

---NLADLLN---QQRM--THDQLWCLMYSLLVSLKLLHSAGVVHR
    |.|..    . ..  . ... . || .|  |. .|| |..||
YVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR

Kinase AqueK119.AA ERK5 397-447 26 0.152098 1.32 In-house 1-52 (295) Show / Hide
Range on Protein: 397-447
Range on HMM: 1-52/295
Sequence Identity: 26% (14 aa)

YRNLEFLTKGSNGSMCFATDTRTSSRVVLSKRDGLYSQ-EYSKRNLRELQLL
|. .| .  |  | .| |   ..  .| . |    . .    || .|||..|
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKIL