Gene AqueK133 (A.queenslandica)

AqueK133

Species: A.queenslandica
Alias: AqueK133
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MOK

Sequence

Name Sequence Type Origin Length Description Download
AqueK133.AA Protein None 474 None Fasta, JSON
AqueK133.kin_dom Protein Kinase Domain None 284 None Fasta, JSON

Protein domain

Protein domains of AqueK133.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK133.AA MOK 11-294 66 1.2e-194 616.07 In-house 1-283 (283) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-283/283
Sequence Identity: 66% (190 aa)

YRVVGAMGEGTFSEVLKCQSLLDGKLYACKKMKQKYSNMTQVNNLREIQALRRLNPHPNVIELKEVIFDRQTGTLSLICELMNMNIYELIKDRRSYLPEA
|. .| .||||||||.| ||| ||  ||||.|||..  . ||||||||||.||||||||...|.||.|||.|| |.|||||| |||||||. || |||. 
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

RVRLYTYQLCKSLYHMHRNGIFHRDVKPENILIKDDLLKLADFGSCKSMYSKLPFTEYISTRWYRAPECLLTDGHYGHKMDMWSVGCVLFELMSLRPLFP
....| ||||||| ||||||||||||||||||||.| |||||||||.|.||| |.|||||||||||||||||||.|  .||||||||| .|..||.||||
KIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLFP

GSNELDQISKIHDVVGTPSSQVLDKFRKIQSKSMDFNFPYKHPTGISILLKHASKQCIDLITKLCTYDPEERPSAKETLRHPYF
| ||.|||||||||.|||  ..| ||.. ||..|...||.|   ||  |.  ..|||.... |.|||||.|| .|.  ..||||
GVNEVDQISKIHDVMGTPCQKILNKFKN-QSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase AqueK133.AA RCK 11-294 46 6.5e-182 582.31 In-house 1-298 (298) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-298/298
Sequence Identity: 46% (138 aa)

YRVVGAMGEGTFSEVLKCQSLLDGKLYACKKMKQKYSNMTQVNNLREIQALRRLNPHPNVIELKEVIFDRQTGTLSLICELMNMNIYELIKD---RRSYL
| ..   |.||...|.| |.. .|...|.||||||...  ...|||||..||.||||||.|.|||||.|. |..|....|.| ||.|...||   || ||
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

PEAR--VRLYTYQLCKSLYHMHRNGIFHRDVKPENILIK----------DDLLKLADFGSCKSMYSKLPFTEYISTRWYRAPECLLTDGHYGHKMDMWSV
||    .. . ||....| |||..|.||||.|||||...          .|..|.||||.|.. .|| |.|.|.||||||||||||....|  .||.|.|
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GCVLFELMSLRPLFPGSNELDQISKIHDVVGTPSSQVLDKFRKIQSKSMDFNFPYKHPTGISILLKHASKQCIDLITKLCTYDPEERPSAKETLRHPYF
||. .||..||||||||.|.||| ||..| |||. . .....| .. .| ||||........ |. ..|..||.|..|....||..|..|.. |.||||
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYK-LASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase AqueK133.AA CMGC 11-294 20 2.5e-112 370.6 In-house 1-513 (513) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-513/513
Sequence Identity: 20% (108 aa)

YRVVGAMGEGTFSEVLKCQS--------------LLDGKLYACKKMKQKYSNMTQVN-----------NLREIQALRRLN----------------PHPN
| ...  ||||...| ||.                 .....| ||.|..  . .|              ||||. |..||                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIELKEVIFDRQTG---------------TLSLICELMNMNIYELIKDRRS--------YLPEAR------------VRLYT------YQLCKSLY--HM
.. |.... ....                 | |. |.| .. |..||. .         .|.|              .. ..      ||....|   ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HRNG--IFHRDVKPENILIKDD---------------------LLKLADFGSCKSMYSKL----------------------PFTEYISTRWYRAPECLL
|...  |.||| ||||||| ..                      ||..|||....  .                        |.|.|..|||||||| ||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

TD---------GHYGHKMDMWSVGCVLFELMS--------LRPLFPGSNE-----------LDQISKIHDVVGTPS---------------SQ----VLD
 .         .||. ..|||||||...|..         ..|||||..|           .||. || .| |||.               ..    ...
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------KFRKIQSKSMDFNFPYKHPTGISILLKH-----------------------------------ASKQCIDLITKLCTYDP
                    .    . ... ..|| ..|  .. | .                                    ...|.|||. |. .|||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

EERPSAKETLRHPYF
..|..|.. |.||||
DKRITAEQALQHPYF
Kinase AqueK133.AA MAK 11-294 33 3.1e-108 345.74 In-house 1-352 (352) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-352/352
Sequence Identity: 33% (119 aa)

YRVVGAMGEGTFSEVLKCQS------------------------------LLDGKLYACKKMKQKYSNMTQVNNLREIQALRRLNPHPNVIELKEVIFDR
| ..  .| ||. .|.. ..                                 | . | |.||.|..      ||||. .|. || |||.. ||||| | 
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

QTGTLSLICELMNMNIYELIKDRRS-YLPEARVRLYTYQLCKSLYHMHRNGIFHRDVKPENILIKD------------------DLLKLADFGSCKSMYS
   .| .. | |  | |...|||.  ..||  .|   ||    | .||..| |||| |||||..                    .|.|.||||      |
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

KLPFTEYISTRWYRAPECLLTDGHYGHKMDMWSVGCVLFELMSLRPLFPGSNELDQISKIHDVVGTPSSQV-----------------LDKFRKIQSKSM
| |.| |.||||||||| ||  . |.  .||| |||.  || ..|||||||.| ||| ||  | ||| ..                   | ..   . .|
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQ--LAHMM

DFNFPYKHP---TGISILLKHASK-QCIDLITKLCTYDPEERPSAKETLRHPYF
 | ||.  |   . .. |.  .|.   |.|....  .||..|| |.. ...|||
NFRFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase AqueK133.AA S_TKc 11-294 29 5.6e-93 316.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

YRVVGAMGEGTFSEVLKCQSLLDGKLYACKKMKQKYSNMTQVNNLREIQALRRLNPHPNVIELKEVIFDRQTGTLSLICELMNM---NIYELIKDRRS--
|...   |.|.|..| ||.   .|...|.|..|         . .|||| |..   |||.. |..|. |   . | .. |...    . ...||.|..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

---YLPEARVRLYTYQLCKSLYHMHRNGIFHRDVKPENILIKDDLLKLADFGSCKSMYSKLPFTEYISTRWYRAPECLLTDGHYGH-KMDMWSVGCVLFE
   ..|| ..| |.||.|. | ..|..|| |||.||||||. .  .|..|||... .      | .. |.||.||| |    .||. | |.||.||.|.|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LMSLRPLFPGSNELDQISKIHDVVGTPSSQVLDKFRKIQSKSMDFNFPYKHPTGISILLKHASKQCIDLITKLCTYDPEERPSAKETLR-------HPYF
... .|.||      |. .. ...|                                     |....|.| |....|||.||.| | |.       ||.|
MLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK133.AA Pkinase 11-294 31 2.4e-83 287.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YRVVGAMGEGTFSEVLKCQSLLDGKLYACKKMKQKYSNMTQ-VNNLR--EIQALRRLNPHPNVIELKEVIFDRQTGTLSLICELMNM-----NIYELIK-
|....  |.|.|..| ||.   .||..|.|..| .  .. . ....|  ||| ..||| |||...|...  |   . . .. |....       ...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

DRRSYL--PEARVRLYTYQLCKSLYHMHRNGIFHRDVKPENILIK-DDLL----KLADFGSCKS--MYSKLPFTEYISTRWYRAPECLLTDGHYGHKMDM
.|.  .  .|  .. | ||... |...|..|| |||.|||||||. .. .    |..|||..|     ..  .| .  |.||.||| .... .||.| ||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSVGCVLFELMSLRPLFPGS----NELDQISKIHDVVGTPSSQVLDKFRKIQSKSMDFNFPYKHPTGISILLKHASKQCIDLITKLCTYDPEERPSAKET
||.||.|.|... ||.|||.    | .||. .|  . |.| .   .. . | | .. |.. . | .  . . . .|. |.|.|......||..||.|.. 
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSI-SYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

LRHPYF
| ||.|
LQHPWF
Kinase AqueK133.AA CDK 11-294 29 1.5e-82 263.94 In-house 1-284 (284) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-284/284
Sequence Identity: 29% (94 aa)

YRVVGAMGEGTFSEVLKCQSLLDG-----KLYACKKMK------QKYSNMTQVNNLREIQALRRLNPHPNVIELKEVIFDRQTG---------TLSLICE
|  .   ||||. .| |......|     ...| || .      ..         .|||  |. |  |||.. |..|. . ..          .|... |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

LMNMNIYELIKDRRSYLPEARVRLYTYQLCKSLYHMHRNGIFHRDVKPENILIKDDL------LKLADFGSCKSMYS------KL-PFTEYISTRWYRAP
 | .  .....          .. |..|| . |...|.|.| ||| || |||| ..       ||.||||  . . .      .. ..|  . |.|||||
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

ECLLTDGHYG--HKMDMWSVGCVLFELMS---LRPLFPGSNELDQISKIHDVVGTPSSQVLDKFRKIQSKSMDFNFPYKHPTGISILLKHASKQCIDLIT
| || . ||.     |||||||.. |..     .|||||..|.||. || .. |||. ..   . | .                            ||. 
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLN

KLCTYDPEERPSAKETLRHPYF
|. .|||. | ||.. | ||||
KMLCYDPKKRISAEQALQHPYF
Kinase AqueK133.AA CDC2 11-294 31 8.7e-75 229.13 In-house 1-301 (301) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-301/301
Sequence Identity: 31% (98 aa)

YRVVGAMGEGTFSEVLKCQSLLDGKLYACKKMKQKYSNMTQ---VNNLREIQALRRLNPHPNVIELKEVIFDRQTGTLSLICELMNMNIYELIK---DRR
|  .   ||||. .| ||. . .... | || . .. .         .|||  |  |..|||.. |..||.      | .. | ..|.  .. .     .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

SYLPEARVRLYTYQLCKSLYHMHRNGIFHRDVKPENILIKDD-LLKLADFGSCKSMYSKLPFTEYI-----STRWYRAPECLLTDGHYGHKMDMWSVGCV
...|.. |. |.||... . . |...|.||| || |||| ..  .|.||||  .      |  .|       |.|||||| || . .|    ||||.||.
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCI

LFEL---MSLRPLFPGSNELDQISKIHDVVGTPSSQVLDKFRKIQSKSMDFNFPYKHPTGISILLKH---------ASKQCIDLITKLCTYDPEERPSAK
. |.   .. .|||.|  | ||. ||  ..|||..| .    . .   ..  ||  .|...|....          . ...|||. ..  |||. | |||
FAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNT--FPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAK

ETLRHPYF
| |.||||
EALQHPYF
Kinase AqueK133.AA GSK 56-294 30 1.7e-63 192.58 In-house 50-328 (328) Show / Hide 
Range on Protein: 56-294
Range on HMM: 50-328/328
Sequence Identity: 30% (86 aa)

REIQALRRLN--PHPNVIELKEVIFDRQTGT--------LSLICELMNMNIYELIKD---RRSYLPEARVRLYTYQLCKSLYHMHRNGIFHRDVKPENIL
|| | ...|    |||.. ||   |.... .        ..|. | |... |..|..    .  .|.  ..||.||....| . |  || |||.||.|||
RELQIMKMLGKLDHPNIVRLK-YFFYMHYEKKDENHVYCNCLVMEYMPQTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNIL

IK--DDLLKLADFGSCKSMYS--KLPFTEYISTRWYRAPECLLTDGHYGHKMDMWSVGCVLFELMSLRPLFPGSNELDQISKIHDVVGTPSSQVLDKFRK
.   .  ||..|||| |   .  . | . || .| ||||| ..   .|... |.||.|||..|..  .||||| ...||.  | .. |||.    . ...
VDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPT---KEQIQS

IQSKSMDFNFP-----YKHPTGISI-------------------LLKH---ASKQCIDLITKLCTYDPEERPSAKETLRHPYF
.  ... |.||     .  |. ..                    ..|     ... ||||.|. .|||..|.|. | . ||.|
MNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase AqueK133.AA CDKL 11-294 33 3.8e-63 214.73 In-house 1-286 (286) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-286/286
Sequence Identity: 33% (98 aa)

YRVVGAMGEGTFSEVLKCQSLLDGKLYACKKMKQ-KYSNMTQVNNLREIQALRRLNPHPNVIELKEVIFDRQTGTLSLICELMNMNIYELIKDRRSYLPE
|   |  |||    |.||     |.. | || |  ..  |   . .|||  |. |  |.|  .|.||   |. . | |  | .  .. .. . . . ..|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLK-HENIVNLIEVF--RRKRKLHLVFEYCDHTVLHELEEYPNGVDE

ARVRLYTYQLCKSLYHMHRNGIFHRDVKPENILIK--DDLLKLADFGSCKSMYSKLP--FTEYISTRWYRAPECLLTDGHYGHKMDMWSVGCVLFELMSL
 .|| |..|..|.. . | . . |||.|||||||   .. .|| |||  . | .|     |.|  |||||||| |. |  ||   |.|..|||. |... 
HVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDG

RPLFPGSNELDQISKIHDVVGTPSSQVLDKFRKIQSKS---MDFNFPY-KHPTGISILLKHAS-KQCIDLITKLCTYDPEERPSAKETLRHPYF
 ||.||....||  .|  ..|.     ...  .| ||.    .  ||  .|.  .   .  .| |  .|.. |.   || ||..... ..||||
QPLWPGQSDIDQLYHIQKCLGP----LIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase AqueK133.AA MAPK 11-294 29 1.1e-58 201.3 In-house 1-328 (328) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-328/328
Sequence Identity: 29% (97 aa)

YRVVGAMGEGTFSEVLKCQSLL------DGKLYACKKMKQKYSNMTQVNN-LREIQALRRLNPHPNVIELKEVIFDRQ---TGTLS------LICELMNM
|. .   |.| .  | ..   .      .||  | ||. .  .| |     .|||  ||... |.|.| |....   .    ..|.      .. |||  
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NIYELIKDRRSYLPEARVRLYTYQLCKS--LYHMHRNGIFHRDVKPENILI-KDDLLKLADFGSCKSMYSK-----------LPF-----TEYISTRWYR
. . .|| ..  | . ...  .||...   | ..|  .. ||| ||.|||. ....||..|||   |  ..           . |     |||..|||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHC-FQKMHMTEYVATRWYR

APECLLTD--GHYGHKMDMWSVGCVLFELMS-LRPLFPGSNELDQISKIHDVVGTPSSQVLDKFR-KIQSKSMDFNF---PYKHPTGISILLK----HAS
||| .|     ||  ..||||||| . |...  .|||||.. .||. .| .|.|||| ... .       ...  ..   |.. .   . ...    .|.
APEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

KQCIDLITKLCTYDPEERPSAKETLRHPYF
 |.|||. |. . ||..| ...| |.||||
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase AqueK133.AA ERK7 11-294 29 7.8e-57 192.79 In-house 1-292 (292) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-292/292
Sequence Identity: 29% (87 aa)

YRVVGAMGEGTFSEVLKCQSLLDGKLYACKKMKQKYSNMTQVN-NLREIQALRRLNPHPNVIELKEVIFDRQTGTLSLICELMNMNIYELIKDRRSYLPE
| .   .| | .  | |      ..  | ||.   . | |      |||  |. .. |||.| | .||       . |. | |.  .   |. . . | .
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIR-KGNILKD

ARVRLYTYQLCKSLYHMHRNGIFHRDVKPENILIKDD-LLKLADFGSCKSMYSKL-------PFTEYISTRWYRAPECLLTDGHYGHKMDMWSVGCVLFE
  ..   ||| . . .||   . |||.|| |||.  . ..|..|||   |. ..          |||. |||||||| ||   .|    ||||.||.| |
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

LMSLRPLFPGSNELDQISKIHDVVGTPSSQVLDKFRKIQSKSMDFNFPYKHPTGISILLKHASKQCIDLITKLCTYDPEERPSAKETLRHPYF
..  .|.|||.  ..|| || .... |. . .       . .|  . . ...  .. ........ |||. .|  . |..| .|.. |.||| 
MLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase AqueK133.AA TyrKc 11-294 18 6.2e-13 -13.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-280/280
Sequence Identity: 18% (58 aa)

YRVVGAMGEGTFSEVLKCQSLLDGKLYACKKMKQKYSNMTQVNNLREIQALRRL-NPHPNVIELKEVIFDRQT-----GTLSLICELMNM-NIYELIKDR
 .     ||| | || |..        | |..|       .   .||.. ...|   |||.. |  |. . .      . | .. |.|   .  . ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

RSYLPEARVRLYTYQLCKSLYHMHRNGIFHRDVKPENILIKDDL-LKLADFGSCKSMYSK---------LPF-----TEY-ISTRWYRAPECLLTDGHYG
|  |. .    . .| ..   . |.... |||    |.|.....  | .||| ..  |..                 . . .  ||. ||||.  .| . 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFT

HKMDMWSVGCVLFELMSL-RPLFPGS----NELDQISKIHDVVGTPSSQVL----DKFRKIQSKSMDFNFPYKHPTGISILLKHASKQCIDLITKLCTYD
.| | || | ...|....  .  ||      . ... .  .  . .                                .    ....   ..... . .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F---VCCPDEMYQIMKQCWHED

PEERPSAKETLRHPYF
||.||. .|   | .|
PEDRPTFSEI--HECF
Kinase AqueK133.AA Pkinase_Tyr 55-205 21 7e-05 17.16 Pfam 51-210 (270) Show / Hide 
Range on Protein: 55-205
Range on HMM: 51-210/270
Sequence Identity: 21% (36 aa)

LREIQALRRLNPHPNVIELKEVIFDRQTGT--LSLICELMNM-NIYELIKDR---RSYLPEARVRLYTYQLCKSLYHMHRNGIFHRDVKPENILIK-DDL
.||.. .. |  |||.. |  |.  .| .   . .. |.|   . ..  ...   .  |.  .   . .| .| . . ..... |||.   |.|.. .  
MREAKIMKQLGHHPNIVRLYGVCT-DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNV

LKLADFGSCKSM-----Y-SKLPFTEYISTRWYRAPECLLTDGHYGHKMDMWSVGCVLFELMSL
 | .||| .. .     |  |   .  .  .|. ||||. .   . .| | || | ...|....
VKICDFGLARDIYNDDYYYRKRGGGK-LPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFTY