AqueK450

Species: A.queenslandica
Alias: AqueK450
External Links:
Annotation:

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
AqueK450.AA Protein None 764 None Fasta, JSON
AqueK450.kin_dom Protein Kinase Domain None 211 None Fasta, JSON

Protein domain

Protein domains of AqueK450.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK450.AA TK 455-519 22 3.1e-18 57.03 In-house 372-486 (486) Show / Hide
Range on Protein: 455-519
Range on HMM: 372-486/486
Sequence Identity: 22% (26 aa)

TEASDVWSFGLTAWQILTLG-EPLPENKDE---------------------------------LRKP--GTCP--------------DSLFELIQWCLES
|..||||||| . | |.|.| || ... .                                  .|.|    ||              . ...|.| | . 
TTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHY

NPKKRPIFSKIVLEI
.|..|| || .. ..
DPEDRPTFSQLHEQL

Kinase AqueK450.AA TKL 446-519 26 7.3e-17 57.25 In-house 259-364 (364) Show / Hide
Range on Protein: 446-519
Range on HMM: 259-364/364
Sequence Identity: 26% (28 aa)

EMEIQGSESTEASDVWSFGLTAWQILTLGEPLPENK------------------DELRKP---------------GTCPDSLFELIQWCLESNPKKRPIF
| ...|.| .|..||.|||.  | |||  .|  ...                  |. ..|                .||.|. .|.|.| ...|.||| |
E-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSF

SKIVLEI
..|. ..
QEILKRL

Kinase AqueK450.AA TyrKc 276-519 21 1.3e-14 13.4 SMART 1-280 (280) Show / Hide
Range on Protein: 276-519
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

LQMNTFLADGPCTEVYQGNYCEPQPHNTCVTHFVAVKRFKVADDSTLVCKYLKQLLRLNKA--THLNVLKLVGVAYGPK------DNVLIAYPYFSEHNL
....  |  |   |||.| .             ||||  |       .   .. .  . |    | |...|.||.  ..      . ..|   | .  .|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

LSYLRKLRLDSKKITDVEKLVDLMHQISKGMNAMARKGLVYGMLSVQTCLIDSEGTVVVGD--LSYYSLVN--------CVKI----NLP--------PP
..|||| | .      ...|.. ..||..||.  ..|...   |    ||.....|| ..|  || .              .     .          .|
KDYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EMEIQGSESTEASDVWSFGLTAWQILTLGEPLPEN-----------------KDELRKPGT--------CPDSLFELIQWCLESNPKKRPIFSKIVLEI
|  |. .. |..||||||| . | |.|.|.. ...                  . ...|          ||| .......| . .|..|| || |. ..
EC-INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase AqueK450.AA Jak 367-521 21 3.9e-13 42.67 In-house 98-299 (299) Show / Hide
Range on Protein: 367-521
Range on HMM: 98-299/299
Sequence Identity: 21% (44 aa)

LLSYLRKLRLDSKKITDV--EKLVDLMHQISKGMNAMARKGLVYGMLSVQTCLIDSEGT------------VVVGDLSYYSLVNCV-KINLP--PPEMEI
|..||.|..  .|.  .    .......|| .||. . .|... | ..    |.|.||              .. .  .|... ..  .. |  .||  .
LDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPEC-L

QGSESTE--ASDVWSFG-LTAWQIL----------------TLG-EPLP-----------ENKDELRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVLE
. .....  |.|.||||  | |.|.                  | .|.            ||.  |  | .|.| ...|.| |.. .| .|| |  |.  
TNCKFYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRD

IDS
...
LNQ

Kinase AqueK450.AA TK-Unique 455-519 28 1.2e-11 36.61 In-house 217-294 (294) Show / Hide
Range on Protein: 455-519
Range on HMM: 217-294/294
Sequence Identity: 28% (22 aa)

TEASDVWSFGLTAWQILTLGEP------------LPENKDELRKPGTC-PDSLFELIQWCLESNPKKRPIFSKIVLEI
|. ||||||| . | |.|||..            .... . . .|  | .. ...|.. |. ..|..|| |..|. ..
TTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase AqueK450.AA TK-Unique 276-429 20 7.5e-11 33.77 In-house 1-177 (294) Show / Hide
Range on Protein: 276-429
Range on HMM: 1-177/294
Sequence Identity: 20% (36 aa)

LQMNTFLADGPCTEVYQGNYCEPQPHNTCVTHFVAVKRFKVADDSTLVCKYLKQLLRLNKAT-HLNVLKLVGVAYGPKDNVLIAYPYFSEHNLLSYLRKL
| ..  . .| . .|. | ....   . . .. ||||  |   . | . ..|| .  ... . | |.....|.   . ....|...| .  ||..|||. 
LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

RLD------------------SKKITD-VE--KLVDLMHQISKGMNAMAR--KGLVYGMLSVQTCLIDSEGTVVVGDL
| .                  .|. |. .    |.  . || .||. .|.  |. |.. |.   .|. . ... ..|.
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDF

Kinase AqueK450.AA TK 276-407 12 8e-11 31.73 In-house 1-262 (486) Show / Hide
Range on Protein: 276-407
Range on HMM: 1-262/486
Sequence Identity: 12% (34 aa)

LQMNTFLADGPCT---EVYQGNYCEPQPHN------------------TCVTHFVAVKRFKVADDSTLVCKYL----------------KQLLRLN--KA
...   |  |      |||.| . .. | |                  . ... ||||  |  |...   . .                  .  ..  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

THLNVLKLVGVAYGPKDN-----------VLIAYPYFSEHN----LLSYLRKLRLDSKK-----------------------------------------
 | |...|.||   .. .           ..|   | .  .    |..|||| | . ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------ITDVEKLVDLMHQISKGMNAMARK------GLV
                              . ... |.  ..||..||  ...|      ..|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFV

Kinase AqueK450.AA Axl 455-517 40 4.7e-10 31.58 In-house 193-267 (267) Show / Hide
Range on Protein: 455-517
Range on HMM: 193-267/267
Sequence Identity: 40% (30 aa)

TEASDVWSFGLTAWQILTLGE-PLP--ENKD---------ELRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVL
|  ||||.|| | | | | |  | |  ||..          |..|  | | |..|.  | | .||.|| ||.. .
TSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE

Kinase AqueK450.AA S_TKc 276-522 16 6.3e-10 -31.35 SMART 1-231 (231) Show / Hide
Range on Protein: 276-522
Range on HMM: 1-231/231
Sequence Identity: 16% (44 aa)

LQMNTFLADGPCTEVYQGNYCEPQPHNTCVTHFVAVKRFKVADDSTLVCKYLKQLLRLNKATHLNVLKLVGVAYGPKDNVLIAYPYFSE--HNLLSYLRK
 ..   .  |   .||..   .         . ||.|. |        .. .. .  | |  | |. || .| .   |.. .   | .    .|..|..|
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKK

LRL-DSKKITDVEKLVDLMHQISKGMNAMARKGLVYGMLSVQTCLIDSEGTVVVGDLSYYSLVNCVKINLPPPEMEIQGSES---------TE-ASDVWS
 .    ..  .      .|.|| .... . ..| ..  |  .  |.|.  .. ..|     ..           . . |.           .  ..|.||
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVLGYGKCKCDWWS

FGLTAWQILTLGEPLPENKDELRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVL-E-----IDSM
.| . .  |.   | | . ... |    .... ..|. ||. .|.|||   ..   |        .
CGCILYEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK450.AA Dicty4 487-521 37 2.3e-09 27.6 In-house 241-277 (277) Show / Hide
Range on Protein: 487-521
Range on HMM: 241-277/277
Sequence Identity: 37% (14 aa)

PGTCPDSLFELIQWCLESNPKKRPIFSKIVLE--IDS
|  ||.|. .|||||.. .|..|| |. |. .   ..
PDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase AqueK450.AA Met 484-513 41 3.9e-09 25.8 In-house 241-271 (271) Show / Hide
Range on Protein: 484-513
Range on HMM: 241-271/271
Sequence Identity: 41% (13 aa)

LRKPGTCPDSLF-ELIQWCLESNPKKRPIFS
|..|  |||.|  .. . | ..|| .|| ||
LPQPEYCPDHLYTDVMLCCWHANPEDRPQFS

Kinase AqueK450.AA TKL 309-399 16 4.1e-08 25.31 In-house 29-146 (364) Show / Hide
Range on Protein: 309-399
Range on HMM: 29-146/364
Sequence Identity: 16% (21 aa)

VAVKRFKVAD--------------------------DSTLVCKYLKQLLRLNKATHLNVLKLVGVAYGPKD------------NVLIAYPYFSEHNLLSY
||||.||. .                           | .  .  .... ...  | |.....|..  |..            .  | . | .  .||.|
VAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHY

LRKLRLDSKKITDVEKLVDLMHQISKGMN
|             .........|..|||
LH-----------WHQRCRWALDIARGMN

Kinase AqueK450.AA InsR 484-521 36 5.6e-08 22.79 In-house 241-278 (278) Show / Hide
Range on Protein: 484-521
Range on HMM: 241-278/278
Sequence Identity: 36% (14 aa)

LRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVLEIDS
||.|  ||. ..|| . |   .|| || |  |.  .  
LRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD

Kinase AqueK450.AA MLK 487-519 39 1.2e-07 22.73 In-house 259-291 (291) Show / Hide
Range on Protein: 487-519
Range on HMM: 259-291/291
Sequence Identity: 39% (13 aa)

PGTCPDSLFELIQWCLESNPKKRPIFSKIVLEI
| |||... .|.. | ...|.||| |. || . 
PSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase AqueK450.AA Pkinase_Tyr 484-519 33 6.3e-07 24.09 Pfam 235-270 (270) Show / Hide
Range on Protein: 484-519
Range on HMM: 235-270/270
Sequence Identity: 33% (12 aa)

LRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVLEI
. .|  ||| . .|.. | . .|..|| || |. ..
MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase AqueK450.AA Pkinase_Tyr 338-399 32 2e-06 22.12 Pfam 63-125 (270) Show / Hide
Range on Protein: 338-399
Range on HMM: 63-125/270
Sequence Identity: 32% (21 aa)

HLNVLKLVGVAYGPKDN--VLIAYPYFSEHNLLSYLRKLRLDSKKITDVEKLVDLMHQISKGMN
| |...|.|| .  ..   ..|  .|    .||.|||| | ..|.  ... |..  .||.|||.
HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-EDKQPLTMKDLLQMCWQIAKGME

Kinase AqueK450.AA UTK 484-519 27 6e-06 16.36 In-house 261-296 (296) Show / Hide
Range on Protein: 484-519
Range on HMM: 261-296/296
Sequence Identity: 27% (10 aa)

LRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVLEI
...|  ||.....| . | ...| .|| |  .| ..
MPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase AqueK450.AA MLK 445-472 36 8e-06 16.28 In-house 202-231 (291) Show / Hide
Range on Protein: 445-472
Range on HMM: 202-231/291
Sequence Identity: 36% (11 aa)

PEME--IQGSESTEASDVWSFGLTAWQILT
||.   ....  .|..||||.|.  |..||
PEVIQQFRCEKYSEKCDVWSWGVVLWEMLT

Kinase AqueK450.AA UTK 338-429 24 0.000121 11.81 In-house 69-169 (296) Show / Hide
Range on Protein: 338-429
Range on HMM: 69-169/296
Sequence Identity: 24% (25 aa)

HLNVLKLVGVAYGPKDNVLIAYPYFSEHNLLSYLRKLRL---DSKKITDVEKLVDLMHQISKGMNAMARKGLVYGMLSVQTCLIDSEG-------TVVVG
| |||.||||    .   .|.. | .. .|.||||. |    .   . . ..... . .|. ||. ....|.| . |  . ||... .       .....
HPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIA

DL
|.
DF

Kinase AqueK450.AA InsR 457-475 63 0.000327 9.94 In-house 201-219 (278) Show / Hide
Range on Protein: 457-475
Range on HMM: 201-219/278
Sequence Identity: 63% (12 aa)

ASDVWSFGLTAWQILTLGE
.|||||||   | . ||||
HSDVWSFGVVLWEMVTLGE

Kinase AqueK450.AA Axl 309-428 22 0.000347 10.47 In-house 30-156 (267) Show / Hide
Range on Protein: 309-428
Range on HMM: 30-156/267
Sequence Identity: 22% (29 aa)

VAVKRFKVADDSTL-VCKYLKQLLRLNKATHLNVLKLVGVAYGPKD-----NVLIAYPYFSEHNLLSYLRKLRLDSK-KITDVEKLVDLMHQISKGMNAM
|||| .|..  .   .  .|.    .    | ||..|.||.   ..     . ..  |.     | ..|   ||. . .   .  ||  |  |  ||  .
VAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLYSRLGDQPFYLPLQMLVKFMVDIACGMEYL

ARKGLVYGMLSVQTCLIDSEGTVVVGD
. .  .   |    |..  . || | |
SNRNFIHRDLAARNCMLREDMTVCVAD

Kinase AqueK450.AA Pkinase 444-510 20 0.000366 15.8 Pfam 179-282 (293) Show / Hide
Range on Protein: 444-510
Range on HMM: 179-282/293
Sequence Identity: 20% (21 aa)

PPEMEIQ-GSESTEASDVWSFGLTAWQILTLGEPLPEN----------KDELRKP--------GTCP-------------------DSLFELIQWCLESN
.||  |. |.. . ..|.||.|.. .. |.   | |.           . .....         .|.                   ... ..| |||. .
APEV-IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

PKKRP
|||||
PKKRP

Kinase AqueK450.AA Dicty4 455-476 54 0.001758 7.67 In-house 195-216 (277) Show / Hide
Range on Protein: 455-476
Range on HMM: 195-216/277
Sequence Identity: 54% (12 aa)

TEASDVWSFGLTAWQILTLGEP
.|..|| |||.  |.|||  ||
NEKADVYSFGIVLWEILTRQEP

Kinase AqueK450.AA UTK 455-474 60 0.002321 7.36 In-house 218-237 (296) Show / Hide
Range on Protein: 455-474
Range on HMM: 218-237/296
Sequence Identity: 60% (12 aa)

TEASDVWSFGLTAWQILTLG
|..||||||| . | |.| |
TTKSDVWSFGVVCWEIWTWG

Kinase AqueK450.AA Pkinase_Tyr 455-479 51 0.002598 11.84 Pfam 192-218 (270) Show / Hide
Range on Protein: 455-479
Range on HMM: 192-218/270
Sequence Identity: 51% (14 aa)

TEASDVWSFGLTAWQILTLG-EP-LPE
|..||||||| . | |.|.| .|  |.
TTKSDVWSFGVLMWEIFTYGEQPTYPG

Kinase AqueK450.AA Met 455-472 55 0.013786 3.97 In-house 197-214 (271) Show / Hide
Range on Protein: 455-472
Range on HMM: 197-214/271
Sequence Identity: 55% (10 aa)

TEASDVWSFGLTAWQILT
| .|||||||   |  .|
TTKSDVWSFGVVMWELMT

Kinase AqueK450.AA Met 338-428 30 0.026395 3.03 In-house 60-147 (271) Show / Hide
Range on Protein: 338-428
Range on HMM: 60-147/271
Sequence Identity: 30% (28 aa)

HLNVLKLVGVAYGPKD-NVLIAYPYFSEHNLLSYLRKLRLDSKKITDVEKLVDLMHQISKGMNAMARKGLVYGMLSVQTCLIDSEGTVVVGD
| |||.|.|..  |   . ..  ||     |... |     .. .. |  |..  ||. |||. || .  |   |    |..| . || |.|
HPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRN---PQNNPC-VRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVAD