Gene CDC2-S2_h (S.moellendorffii)

CDC2-S2_h

Species: S.moellendorffii
Alias: CDC2-S2_h
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2-smoe2

Sequence

Name Sequence Type Origin Length Description Download
CDC2-S2_h.AA Protein None 510 None Fasta, JSON
CDC2-S2_h.NA RNA None 1533 None Fasta, JSON
CDC2-S2_h.kin_dom Protein Kinase Domain None 271 None Fasta, JSON

Protein domain

Protein domains of CDC2-S2_h.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC2-S2_h.AA STE 34-77 22 0.000168 11.95 In-house 60-115 (359) Show / Hide 
Range on Protein: 34-77
Range on HMM: 60-115/359
Sequence Identity: 22% (13 aa)

NKGKGE------EVHKQILKEFEIMVNCK--HENVLDVIDMGLDK------DGNYYMV
.. . |      | ..||||| .|| .|.  |.|.   ... ...      |.. ...
EN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWIC
Pkinase CDC2-S2_h.AA Pkinase 31-77 24 0.009883 10.74 Pfam 31-78 (293) Show / Hide 
Range on Protein: 31-77
Range on HMM: 31-78/293
Sequence Identity: 24% (12 aa)

VIKNKGKGEEVHKQILK--EFEIMVNCKHENVLDVIDMGLDKDGNYYMV
.|| ... ...... ..  | .|| ...|.|..  .|.  | ....|||
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMV
Kinase CDC2-S2_h.AA CAMKL 100-165 24 0.001408 7.12 In-house 214-282 (297) Show / Hide 
Range on Protein: 100-165
Range on HMM: 214-282/297
Sequence Identity: 24% (18 aa)

GTAVDIWSAGILLVGML---LPLEMPELPEKEAKGEVLETIKKFLRALDDLIK-----DKDALELIKSMLASDP
| .|||||.|..|  |.   || . . .. | .. .   . ..  . .   .      . |.  ||..||  .|
GPKVDIWSCGVILYAMVCGYLPFDDDTYN-K-QGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNP
Kinase CDC2-S2_h.AA CAMK 92-112 21 0.002405 5.84 In-house 287-324 (425) Show / Hide 
Range on Protein: 92-112
Range on HMM: 287-324/425
Sequence Identity: 21% (8 aa)

P-PETTLK----------------VGTAVDIWSAGILL
. ||  ..                .| ..|.||.|..|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase CDC2-S2_h.AA Pkinase 100-165 17 0.006025 11.5 Pfam 190-278 (293) Show / Hide 
Range on Protein: 100-165
Range on HMM: 190-278/293
Sequence Identity: 17% (16 aa)

GTAVDIWSAGILLVGMLL--PLEMPELPEKEAKGEVLETIKKFLRALDDLIKD-----------------------KDALELIKSMLASDP
|..||.||.|..|  ||.  |.   .    .   . .. |.. ...  .   .                       ......||..|. ||
GPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP
Kinase CDC2-S2_h.AA CMGC 100-117 33 0.029791 2.16 In-house 313-330 (513) Show / Hide 
Range on Protein: 100-117
Range on HMM: 313-330/513
Sequence Identity: 33% (6 aa)

GTAVDIWSAGILLVGMLL
.|..|.||.|  .  |..
TTPIDMWSVGCIFAEMYT
Kinase CDC2-S2_h.AA RCK 151-172 52 0.042888 2.11 In-house 269-293 (298) Show / Hide 
Range on Protein: 151-172
Range on HMM: 269-293/298
Sequence Identity: 52% (13 aa)

KDALELIKSMLASDP---ITARQAL
.|..||.. ||. ||   ||| |||
QDCIELMEKMLQWDPQKRITAQQAL
Kinase CDC2-S2_h.AA CDK 100-109 60 0.048662 2.13 In-house 200-209 (284) Show / Hide 
Range on Protein: 100-109
Range on HMM: 200-209/284
Sequence Identity: 60% (6 aa)

GTAVDIWSAG
||..|.||.|
GTPIDMWSVG
Kinase CDC2-S2_h.AA CDK7 152-174 31 0.049313 0.72 In-house 440-468 (288) Show / Hide 
Range on Protein: 152-174
Range on HMM: 440-468/288
Sequence Identity: 31% (9 aa)

DALELIKSMLASDP---ITARQALA---F
|.|.|.. |.. .|   .|..|.|    |
DLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDC2-S2_h.AA CDC2 150-173 37 0.104338 0.43 In-house 271-297 (301) Show / Hide 
Range on Protein: 150-173
Range on HMM: 271-297/301
Sequence Identity: 37% (10 aa)

DKDALELIKSMLASDP---ITARQALA
|.....|...||. ||   |.|..||.
DPEGIDLLMQMLQYDPQKRISAKEALQ
Kinase CDC2-S2_h.AA MAPK 101-116 50 0.196275 0.45 In-house 213-228 (328) Show / Hide 
Range on Protein: 101-116
Range on HMM: 213-228/328
Sequence Identity: 50% (8 aa)

TAVDIWSAGILLVGML
.|||.||.|  .  ||
KAVDMWSVGCIFAEML
Kinase CDC2-S2_h.AA S_TKc 201-471 25 1.1e-50 175.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 201-471
Range on HMM: 1-231/231
Sequence Identity: 25% (76 aa)

VSGARLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDAIINESEILEEVAHDNVVNLFGLTCNNQGTFMVMELMDG---SLSDVISSRK-------L
    |..| || |.|. . |.||| .||.|..       . |..| .||..  |.|.|.|..   . .  .||||..||   .| |.| .|.       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

GEHDIRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATARAADTPLGAT---------SFGT-AIDVWGARCIFAEMLLGSNPF
 | ..| .|.||...|. .| |.|.| |.| .|.|. .       ..|..||  ||   | .  |         ..|. ..|.|   ||..||| |  ||
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPF

DVPDEEDGDSLDYFVADFAKKLDIDGCGMGYQDRRRERARERILEKMVWWKAEDVRSGIKDPDAVELLKRMLAIDPARRISAQNALK-------MPYF
.             ..   ||.                                      .|.| ......|  ||..|..|  ||.       .|.|
P------------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC2-S2_h.AA Pkinase 205-342 29 4.3e-34 121.64 Pfam 5-156 (293) Show / Hide 
Range on Protein: 205-342
Range on HMM: 5-156/293
Sequence Identity: 29% (45 aa)

RLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDAIIN-----ESEILEEVAHDNVVNLFGLTCNNQGTFMVMELMDG-----SLSDVIS---SRKL-
| .|.|. |.|. . |..||..||.|..  ..   .  ..     | .|. .. |.|.| |..   ...   ||||...|     .|.|.||   .... 
RKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY

-GEHDIRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADF
  |.... .|.|||.||. .|...|.| |.| .|.|....|. .   ||..||
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDF
Kinase CDC2-S2_h.AA STE 201-342 24 2.1e-32 111.75 In-house 1-191 (359) Show / Hide 
Range on Protein: 201-342
Range on HMM: 1-191/359
Sequence Identity: 24% (49 aa)

VSGARLLGAGADGEVRVGFHRK---------------TGDKVAMKKMYEHEY------------------LYDAIINESEILEEVA--HDNVVNLFGLTC
  | . .| || |.|  . ..|               ||. .|.|.|   .                     . |..| .|. .    |.|.|. .|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NN-------QGTFMVMELMD-GSLSDVIS---SRKLG------------EHDIRAVMRQILEG-LAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLAD
..       .  ...||.|| |||.|.|    ... .            |. |... ||||.| |. .| |.|.| |.| .|.|.          |||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCD

F
|
F
Kinase CDC2-S2_h.AA CAMK 206-346 17 1.1e-30 95.5 In-house 1-244 (425) Show / Hide 
Range on Protein: 206-346
Range on HMM: 1-244/425
Sequence Identity: 17% (43 aa)

LLGAGADGEVRVGFHRKTG------------DKVAMKKMY-----------------------------EHEYLYDAIINESEILEEVA-------HDNV
 || |. |.|. ..|..|.             |||.| .                              . ..  . . .| ||.  .        | |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLFGLTC------------NNQG--------TFMVM---ELMDG-----SLSDVISSR----------------KLGEHDIRAVMRQILEGLAWIHAHR
..|.                . .          .|||   |...|      | | | ..                .. |.. | ..|||..... .| | 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHQDVKTSNVLVKRDGEKNK------------FVVKLADFATAR
||| | |  |.|.  ... .             . .|..||  |.
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFAN
Kinase CDC2-S2_h.AA CMGC 201-351 18 2.7e-29 92.67 In-house 1-257 (513) Show / Hide 
Range on Protein: 201-351
Range on HMM: 1-257/513
Sequence Identity: 18% (47 aa)

VSGARLLGAGADGEVRVGFH--------------RKTGDKVAMKKMYEHEYLYDAI------------INESEILEEVA-----------------HDNV
    . .| |. |.|  ...              ..|. .||.||. . .|  .|             . | .||...                  | |.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNLFGLTCNNQ-----------------GTFMVMELMDGSLSDVISSRK----------LGEHD------------IRAVM------RQILEGLA--WIH
|.|.     ..                   ..|.|.|| .| ..| . .          | |              |.  |      .|||.||.   .|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

AHR--IVHQDVKTSNVLVKRDGEK---------------NKFVVKLADFATARAADTP
 |.  |.| | | .|.|.  ..|                 ....|..||  ||. ...
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase CDC2-S2_h.AA CAMKL 200-342 25 1.9e-25 78.06 In-house 1-173 (297) Show / Hide 
Range on Protein: 200-342
Range on HMM: 1-173/297
Sequence Identity: 25% (46 aa)

WVSGARLLGAGADGEVRVGFH-RKTGDKVAMKKMYEHEYLYDAIIN----------------ESEILEEVA---HDNVVNLFGLTCNNQG------TFMV
.  |   || |. |.|. . | | || |||.| .       | ...                | .|.. .    | |.. |.    . .        ..|
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MELMDGS---LSDVISSR-----KLGEHDIRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADF
||. .|    | | | ..     .. ||. |   |||..... .| |.||| | |  |.|.  .|     ..|..||
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDF
Kinase CDC2-S2_h.AA CDK 248-342 29 1.2e-22 69.08 In-house 61-157 (284) Show / Hide 
Range on Protein: 248-342
Range on HMM: 61-157/284
Sequence Identity: 29% (32 aa)

ILEEVAHDNVVNLFGLTCNN-----------QGTFMVMELMDGSLSDVISSRKLGEHDIRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGE-KNKF
.| |  |.|.|.|.     .              .||.| ||  |. ...        |.  |.|.|.||. .| ..|.| | |..| |. ..|| |   
LLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVK-CG

VVKLADF
..|.|||
RLKIADF
Kinase CDC2-S2_h.AA CDC2 204-351 28 1.6e-18 53.08 In-house 4-156 (301) Show / Hide 
Range on Protein: 204-351
Range on HMM: 4-156/301
Sequence Identity: 28% (46 aa)

ARLLGAGADGEVRVGFHRKTGDKVAMKKM-YEHEYLY----DAIINESEILEEVA-HDNVVNLFGLTCNNQGTFMVMELMDGSLSDVIS----S-RKLGE
 . .| |  |.|  . ...|.. ||.||   |.|         .| |  .| |   |.|.| |.    . .  .|| | .|  |         .  .. .
IEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPP

HDIRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATARAADTP
. ..  | |||.|..  |..||.| | | .| |. ..|.     .|.|||  |||  .|
QLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-----IKIADFGLARAFGIP
Kinase CDC2-S2_h.AA CDK7 202-347 30 3.6e-18 44.57 In-house 2-151 (288) Show / Hide 
Range on Protein: 202-347
Range on HMM: 2-151/288
Sequence Identity: 30% (48 aa)

SGARLLGAGADGEVRVGFHRKTGDKVAMKKMY---EHEYLYDAI----INESEILEEVAHDNVVNLFGLTCNNQGTFMVMELMDGSLSDVISSRK--LGE
   ...|.|  . |  .   .|| .|| ||       .   | |    | |  || |  ||||..|           .|...||  |  ||   .  |  
EKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILTP

HDIRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATARA
 .| | | ..| || . |.. | | | |  | |.  .|     ..|.|||  ||.
AHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENG-----QLKIADFGLARF
Kinase CDC2-S2_h.AA RCK 207-346 31 7.9e-18 52.88 In-house 7-162 (298) Show / Hide 
Range on Protein: 207-346
Range on HMM: 7-162/298
Sequence Identity: 31% (49 aa)

LGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDAIINESEI--LEEVA-HDNVVNLFGLTCNNQ--GTFMVMELMDGSLSDVISS----RK-LGEHD--
||.|. |.|  .   .||..||.|||  . |  . ..|  ||  |  .  |.|...|.    .|     . |.|.||  |.  . .    || | |    
LGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRS

IRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVKRD----GEKNKFVVKLADFATAR
|.  | ||| ||| .| | . | |.|  | ... .     ... ...|.|||  .|
IKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCR
Kinase CDC2-S2_h.AA CDK7 443-471 37 7.6e-16 38.26 In-house 260-288 (288) Show / Hide 
Range on Protein: 443-471
Range on HMM: 260-288/288
Sequence Identity: 37% (11 aa)

DAVELLKRMLAIDPARRISAQNALKMPYF
|...|...|.. .| .|...  .||||||
DLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDC2-S2_h.AA CDC2 441-471 54 8.4e-15 41.41 In-house 271-301 (301) Show / Hide 
Range on Protein: 441-471
Range on HMM: 271-301/301
Sequence Identity: 54% (17 aa)

DPDAVELLKRMLAIDPARRISAQNALKMPYF
||....||..||..||..||||. ||. |||
DPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDC2-S2_h.AA RCK 442-471 53 1.1e-14 42.74 In-house 269-298 (298) Show / Hide 
Range on Protein: 442-471
Range on HMM: 269-298/298
Sequence Identity: 53% (16 aa)

PDAVELLKRMLAIDPARRISAQNALKMPYF
.|..||.. ||..||  ||.|| ||..|||
QDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase CDC2-S2_h.AA CMGC 441-471 58 4.6e-14 41.68 In-house 483-513 (513) Show / Hide 
Range on Protein: 441-471
Range on HMM: 483-513/513
Sequence Identity: 58% (18 aa)

DPDAVELLKRMLAIDPARRISAQNALKMPYF
||.|..|||.|| .||..||.|. ||..|||
DPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CDC2-S2_h.AA CDK 424-471 33 7.7e-13 37.25 In-house 252-284 (284) Show / Hide 
Range on Protein: 424-471
Range on HMM: 252-284/284
Sequence Identity: 33% (16 aa)

LEKMVWWKAEDVRSGIKDPDAVELLKRMLAIDPARRISAQNALKMPYF
..|. ..               .|| .||. ||..||||. ||..|||
VTKLPDY---------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDC2-S2_h.AA MAPK 272-350 37 1.4e-12 39.55 In-house 93-169 (328) Show / Hide 
Range on Protein: 272-350
Range on HMM: 93-169/328
Sequence Identity: 37% (31 aa)

MVMELMDGSLSDVISSRK-LGEHDIRAVMRQILEG--LAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATARAADT
.|||||.  |  .| |.. | .. |.  | ||| |  |  ||  ...| | | ||.||  ...     .|..||  || .|.
IVMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCD-----LKICDFGLARSIDP
Kinase CDC2-S2_h.AA Pkinase 353-471 19 1.5e-12 45.41 Pfam 185-293 (293) Show / Hide 
Range on Protein: 353-471
Range on HMM: 185-293/293
Sequence Identity: 19% (24 aa)

GATSFGTAIDVWGARCIFAEMLLGSNPFDVP----DEEDGDSLDYFVADFAKKLDID--GCGMGYQDRRRERARERILEKMVWWKAEDVRSGIKDPDAVE
|..  |...|.|.. ||..|||.|  ||.      .  | . . . . .   . |..   ... .  .|. . .          . . ..    .... .
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------F-HWTF-HNWSEECKD

LLKRMLAIDPARRISAQNALKMPYF
..|..|. ||..|..|. .|. |.|
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase CDC2-S2_h.AA GSK 245-342 29 2.9e-12 33.16 In-house 51-161 (328) Show / Hide 
Range on Protein: 245-342
Range on HMM: 51-161/328
Sequence Identity: 29% (34 aa)

ESEILEEV---AHDNVVNL---FGLTCNNQGT------FMVMELMDGSLSDVIS-----SRKLGEHDIRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVK
| .|....    | |.|.|   |   ....          ||| |   |..||       ... . .|.  | |.. ||| .| | |.| |.| .|.|| 
ELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVD

RDGEKNKFVVKLADF
.|      |.|..||
PDT----GVLKICDF
Kinase CDC2-S2_h.AA MAPK 439-471 45 4.9e-12 37.68 In-house 296-328 (328) Show / Hide 
Range on Protein: 439-471
Range on HMM: 296-328/328
Sequence Identity: 45% (15 aa)

IKDPDAVELLKRMLAIDPARRISAQNALKMPYF
...|.|. ||..||..|| .||... ||  |||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDC2-S2_h.AA TyrKc 201-451 19 4.3e-11 -43.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 201-451
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

VSGARLLGAGADGEVRVGFHRKTGDKVAMKKMYEHEYLYDAIINESEILEEV--AHDNVVNLFGLTCNN-------QGTFMVMELMD-GSLSDVISSRK-
..  . || || |||. |  .    .|| |.. |.     ....| .|. ..   |.|.|.|.|            .  ..|||.|. |.| | . ... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LGEHDIRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADFATARAA-----------DTPL----GAT----------------SF
 |   |    . || .| . .| ....| |  . |.||....     .|| .||  .|.                    |.                  |
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GTAIDVW--GARCIFAEML-LGSNPFDVPDEEDGDSLDYFVADFAKKLDIDGCGMGYQDRRRER--------ARERILEKMVW-WKA-EDVRSGIKDPDA
 |. |||  |  |.. |.. .|  |   . ..   | .  ...  .         ||  .. .         . . . . | . |..  . |     |  
TTKSDVWSFGV-CMW-EIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQ---------GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR-----PTF

VELLKRM
 |. ...
SEIHECF
Kinase CDC2-S2_h.AA GSK 440-471 31 5.7e-11 29.14 In-house 297-328 (328) Show / Hide 
Range on Protein: 440-471
Range on HMM: 297-328/328
Sequence Identity: 31% (10 aa)

KDPDAVELLKRMLAIDPARRISAQNALKMPYF
...|...|....| .||  |.|.  |...|.|
DMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase CDC2-S2_h.AA Pkinase_Tyr 201-342 26 4.1e-10 34.87 Pfam 1-155 (270) Show / Hide 
Range on Protein: 201-342
Range on HMM: 1-155/270
Sequence Identity: 26% (42 aa)

VSGARLLGAGADGEVRVGFHR----KTGDKVAMKKM---YEHEY-LYDAIINESEILEEV-AHDNVVNLFGLTC-NNQG--TFMVMELMDG-SLSDVISS
..  . ||.|| |||. |  .    .|. .|| |..   . ||  . .. ..| .|. .   |.|.|.| |      .    ..|||.| . .| |   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R-----KLGEHDIRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGEKNKFVVKLADF
.     .|  .|.    .|| .|... ......| |. . |.||..     ..||| .||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-----NNVVKICDF
Kinase CDC2-S2_h.AA GSK 352-376 48 1.6e-09 24.65 In-house 191-215 (328) Show / Hide 
Range on Protein: 352-376
Range on HMM: 191-215/328
Sequence Identity: 48% (12 aa)

LGATSFGTAIDVWGARCIFAEMLLG
.|.| ....|||| . |..||||.|
FGCTNYTCQIDVWSCGCVMAEMLKG
Kinase CDC2-S2_h.AA CDK 352-380 38 2.5e-08 22.57 In-house 192-225 (284) Show / Hide 
Range on Protein: 352-380
Range on HMM: 192-225/284
Sequence Identity: 38% (13 aa)

LGATSFG--TAIDVWGARCIFAEMLL---GSNPF
||..  .  |.||.|.. ||||||..   .   |
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLF
Kinase CDC2-S2_h.AA CAMK 441-471 25 1.5e-07 19.68 In-house 395-425 (425) Show / Hide 
Range on Protein: 441-471
Range on HMM: 395-425/425
Sequence Identity: 25% (8 aa)

DPDAVELLKRMLAIDPARRISAQNALKMPYF
....  |...||  || .|.... .|. | .
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CDC2-S2_h.AA CDK7 353-375 52 2.2e-07 15.29 In-house 176-198 (288) Show / Hide 
Range on Protein: 353-375
Range on HMM: 176-198/288
Sequence Identity: 52% (12 aa)

GATSFGTAIDVWGARCIFAEMLL
|| ..||..|.|   ||||| .|
GARHYGTGVDMWSVGCIFAELML
Kinase CDC2-S2_h.AA CMGC 352-380 31 1e-06 16.62 In-house 298-342 (513) Show / Hide 
Range on Protein: 352-380
Range on HMM: 298-342/513
Sequence Identity: 31% (14 aa)

LGA---------TSFGTAIDVWGARCIFAEMLLG-------SNPF
||.         . ..|.||.|.. ||||||..|         |.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase CDC2-S2_h.AA CAMKL 441-471 22 3e-06 15.66 In-house 268-297 (297) Show / Hide 
Range on Protein: 441-471
Range on HMM: 268-297/297
Sequence Identity: 22% (7 aa)

DPDAVELLKRMLAIDPARRISAQNALKMPYF
. |.  |...||  .| .|..... .. | .
S-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase CDC2-S2_h.AA STE 439-471 17 0.000744 9.64 In-house 303-359 (359) Show / Hide 
Range on Protein: 439-471
Range on HMM: 303-359/359
Sequence Identity: 17% (10 aa)

IKD----------------------PDAVELLKRMLAIDPARRISAQNALK--MPYF
..|                      |.  . ... | .||  | .|.  ||   | .
LPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CDC2-S2_h.AA MAPK 359-376 52 0.000933 8.61 In-house 213-231 (328) Show / Hide 
Range on Protein: 359-376
Range on HMM: 213-231/328
Sequence Identity: 52% (10 aa)

TAIDVWGARCIFAEMLL-G
.|.|.| . |||||||  .
KAVDMWSVGCIFAEMLTDR
Kinase CDC2-S2_h.AA CDC2 352-373 50 0.001879 5.89 In-house 178-199 (301) Show / Hide 
Range on Protein: 352-373
Range on HMM: 178-199/301
Sequence Identity: 50% (11 aa)

LGATSFGTAIDVWGARCIFAEM
||.    |..|.|   ||||||
LGCKRYSTPVDMWSIGCIFAEM
Kinase CDC2-S2_h.AA MAPK 201-232 28 0.079961 1.82 In-house 1-38 (328) Show / Hide 
Range on Protein: 201-232
Range on HMM: 1-38/328
Sequence Identity: 28% (11 aa)

VSGARLLGAGADGEVRVGFHRK------TGDKVAMKKM
    . .| || | |   ....      .|.||| ||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKI