Gene CRK7_e (S.moellendorffii)

CRK7_e

Species: S.moellendorffii
Alias: CRK7_e
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CRK7

Sequence

Name Sequence Type Origin Length Description Download
CRK7_e.AA Protein None 159 None Fasta, JSON
CRK7_e.NA RNA None 480 None Fasta, JSON
CRK7_e.kin_dom Protein Kinase Domain None 137 None Fasta, JSON

Protein domain

Protein domains of CRK7_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CRK7_e.AA CMGC 20-154 23 1.5e-43 140.38 In-house 1-211 (513) Show / Hide 
Range on Protein: 20-154
Range on HMM: 1-211/513
Sequence Identity: 23% (52 aa)

YVAVESIGRGKYGKVFLATDKQTS--------------ERVAIKRLRVDPKEATLKVREAGGELRDVPA--------SIAIEIKVLRLLN----------
|  .. ||.| ||.|. ..||.|               |.||||... .. . . .            .        ..  ||| |. ||          
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKS----------TIEKDGFPIRALREIKILKHLNKNHDPNWQRR

-----NDH--VVKLLDVIYAAT-----------------DIFLVFEYMKHDLCGLIHRHK----------FSAPE------------IKCYL------KQ
     ..|  .|||.|..|                    ...|||||| |||...|....          .|  .            ||...      .|
DDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQ

ILEGLH--YCHLNG--VMHRDIK
||.||.  ||| ..  ..|||.|
ILRGLKLKYCHSHWGNIIHRDLK
Kinase CRK7_e.AA CDC2 20-154 33 4.6e-36 107.94 In-house 1-130 (301) Show / Hide 
Range on Protein: 20-154
Range on HMM: 1-130/301
Sequence Identity: 33% (48 aa)

YVAVESIGRGKYGKVFLATDKQTSERVAIKRLRVDPKEATLKVREAGGELRD-VPASIAIEIKVLRLLN-NDHVVKLLDVIYAATDIFLVFEYMKHDLCG
|  .| || | ||.|. . |.|| . ||.|. |..  ..            | || ..  ||  |  |.  . .||| |||.    ...||||. .||  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEG-----------DGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKK

LIH-----RHKFSAPEIKCYLKQILEGLHYCHLNGVMHRDIK
.       . ...   .| |..|||.|.|.|| ...||||.|
YMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLK
Kinase CRK7_e.AA Pkinase 20-156 28 1e-33 120.32 Pfam 1-137 (293) Show / Hide 
Range on Protein: 20-156
Range on HMM: 1-137/293
Sequence Identity: 28% (43 aa)

YVAVESIGRGKYGKVFLATDKQTSERVAIKRLRVDPKEATLKV----REAGGELRDVPASIAIEIKVLRLLNNDHVVKLLDVIYAATDIFLVFEYMKH--
|. .. ||.| .|.|.....| |...||.|..... ..   ..    .               ||.... || ...|.|.|. .  ..| .|.||. .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--------------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGL

---DLCGLIH---RHKF--SAPEIKCYLKQILEGLHYCHLNGVMHRDIKSS
   ||. .|.   . .|  |  |.|.|..|||.|| ||| .|..|||.|..
YVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPE
Kinase CRK7_e.AA CDK 79-154 40 1.2e-32 101.6 In-house 58-135 (284) Show / Hide 
Range on Protein: 79-154
Range on HMM: 58-135/284
Sequence Identity: 40% (35 aa)

EIKVLRLLNNDHVVKLLDVIYAA-----------TDIFLVFEYMKHDLCGLIHRHKFSAPEIKCYLKQILEGLHYCHLNGVMHRDIK
||. |. | ....|||.||..             . ...||||| ||| ....        ||||..|.|.|||||| |..||||.|
EISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLK
Kinase CRK7_e.AA CAMKL 20-154 29 2.4e-31 97.16 In-house 1-154 (297) Show / Hide 
Range on Protein: 20-154
Range on HMM: 1-154/297
Sequence Identity: 29% (47 aa)

YVAVESIGRGKYGKVFLATD-KQTSERVAIKRLR-----VDPKEATL---KVREAGGELRDVPASIAIEIKVLRLLN---NDHVVKLLDVIYAATD----
|  .. .|.| .||| |||. . | |.|||| .       ||.       . .       ...  |  ||. ...||     ...||..||.  .     
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH------ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET

--IFLVFEYM-KHD--LCGLIHRH-----KFSAPEIKCYLKQILEGLHYCHLNGVMHRDIK
  |.|| ||    .  |   | .|     ... .| . | .||.....||| .|. |||||
KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIK
Kinase CRK7_e.AA CAMK 25-154 18 3.8e-31 97.05 In-house 1-206 (425) Show / Hide 
Range on Protein: 25-154
Range on HMM: 1-206/425
Sequence Identity: 18% (39 aa)

SIGRGKYGKVFLATDKQTS------------ERVAIKRLRVDP--------------KEATLKVREAGGELRDVPASIAIEIKVLRL-------LNNDHV
 .||| .|||.|...|.|             ..|||| .  .               .. . . . .  .     ...  ||.....       |.  ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLLDVIY------------AATD--------IFLVF---EYMKH-----DLCGLIHRH----------------KFSAPEIKCYLKQILEGLHYCHLNG
.||..|.               ..        ...|.   ||.       ||   | .|                .|.  | . | .||....|||| ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VMHRDIK
..|||.|
IVHRDLK
Kinase CRK7_e.AA STE 20-156 21 3.3e-26 89.61 In-house 1-181 (359) Show / Hide 
Range on Protein: 20-156
Range on HMM: 1-181/359
Sequence Identity: 21% (41 aa)

YVAVESIGRGKYGKVFLATDK------QTSER---------VAIKRLRVDPK-------EATLKVREAGGELRDV----PASIAIEIKVLRLLN--NDHV
.  .| ||.| .|.|..| ..      .| |          .|||.......       |.   .      |...      .|  |||... .|   ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-E------LENKNHEEMQQILKEIKIMKKCNHMHPNI

VKLLDVIYAA-------TDIFLVFEYMKH-DLCGLIHR---------------HKFSAPEIKCYLKQILEG-LHYCHLNGVMHRDIKSS
|| ..  .         ...... |||    |  .|..               |.|. ..|.....|||.| |.| | ....|||||..
VKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPA
Kinase CRK7_e.AA RCK 78-154 34 5.5e-25 75.96 In-house 46-132 (298) Show / Hide 
Range on Protein: 78-154
Range on HMM: 46-132/298
Sequence Identity: 34% (30 aa)

IEIKVLRLLN-NDHVVKLLDVIYAAT--DIFLVFEYMKHDLCGLIHR-----HKFSAPE--IKCYLKQILEGLHYCHLNGVMHRDIK
.|||.|| || .....||..||.  .    ..|||||. .|  ..       .... ..  || ...||| ||...| .| .|||.|
REIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLK
Kinase CRK7_e.AA CRK7 79-156 40 1.7e-23 77.69 In-house 51-141 (343) Show / Hide 
Range on Protein: 79-156
Range on HMM: 51-141/343
Sequence Identity: 40% (37 aa)

EIKVLRLLNNDHVVKLLDVIYAA----------TDIFLVFEYMKHDLCGLIHRH--K-FSAPEIKCYLKQILEGLHYCHLNGVMHRDIKSS
|||.|| || . .|.| ...               ...||||| ||| ||      . ||  ..||..||.|||. ||| ....||||| |
EIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCS
Kinase CRK7_e.AA CDK-DD1 106-156 49 1.7e-21 62.61 In-house 75-127 (379) Show / Hide 
Range on Protein: 106-156
Range on HMM: 75-127/379
Sequence Identity: 49% (26 aa)

LVFEYMKHDLCGLIHRHK--FSAPEIKCYLKQILEGLHYCHLNGVMHRDIKSS
.||||. ||| ...  |.   | | |||. .| |||.  || .|.|||||| .
MVFEYFEHDLWKFMSNHQCYMSLPCIKCFFHQLLEGINECHNQGIMHRDIKPA
Kinase CRK7_e.AA PITSLRE 102-156 41 9.8e-16 53.93 In-house 76-135 (295) Show / Hide 
Range on Protein: 102-156
Range on HMM: 76-135/295
Sequence Identity: 41% (25 aa)

TDIFLVFEYMKHDLCGLIHRHK-----FSAPEIKCYLKQILEGLHYCHLNGVMHRDIKSS
. |..|.||. ||| .|.  .|     |. .|||| . | | | .. | | .|||| | |
DKIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTS
Kinase CRK7_e.AA CDK 20-54 42 3.9e-12 34.96 In-house 1-40 (284) Show / Hide 
Range on Protein: 20-54
Range on HMM: 1-40/284
Sequence Identity: 42% (17 aa)

YVAVESIGRGKYGKVFLATDKQTS-----ERVAIKRLRVD
|  .| ||.| ||.|. | ||||      . ||.|..|..
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRME
Kinase CRK7_e.AA S_TKc 20-159 16 3.8e-11 -13.41 SMART 1-220 (231) Show / Hide 
Range on Protein: 20-159
Range on HMM: 1-220/231
Sequence Identity: 16% (41 aa)

YVAVESIGRGKYGKVFLATDKQTSERVAIKRLRVDPKEATLKVREAGGELRDVPASIAIEIKVLRLLNNDHVVKLLDVIYAATDIFLVFEYMKH---DLC
|  .. ||.| .|||.....| | ..||||...                      .|  ||..|.  . ...|||.||..  .....|.||. .   || 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLF

GLIHRHK-------FSAPEIKCYLKQILEGLHYCHLNGVMHRDIKSS------------------------------------SR---------------
 .|....       |.  ....|..||...| ||| .|..|||.| .                                    ..               
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEM

-------------------------------------------T
                                           .
LCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase CRK7_e.AA RCK 20-51 43 1.9e-09 25.87 In-house 1-32 (298) Show / Hide 
Range on Protein: 20-51
Range on HMM: 1-32/298
Sequence Identity: 43% (14 aa)

YVAVESIGRGKYGKVFLATDKQTSERVAIKRL
| ... .|.| || |..| .| | | ||||..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKM
Kinase CRK7_e.AA CRK7 20-54 45 4.3e-08 23.78 In-house 1-35 (343) Show / Hide 
Range on Protein: 20-54
Range on HMM: 1-35/343
Sequence Identity: 45% (16 aa)

YVAVESIGRGKYGKVFLATDKQTSERVAIKRLRVD
|  .. || | ||.|  | .|.| | || |..| |
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMD
Kinase CRK7_e.AA CDK-DD1 20-53 38 9.5e-08 19.36 In-house 1-34 (379) Show / Hide 
Range on Protein: 20-53
Range on HMM: 1-34/379
Sequence Identity: 38% (13 aa)

YVAVESIGRGKYGKVFLATDKQTSERVAIKRLRV
|. .. .| | ||.|| |  | | . || |.  .
YQIISKCGQGIYGSVFKAIHKITHCMVALKNFKD
Kinase CRK7_e.AA PITSLRE 20-57 43 1.5e-07 23.81 In-house 1-39 (295) Show / Hide 
Range on Protein: 20-57
Range on HMM: 1-39/295
Sequence Identity: 43% (17 aa)

YVAVESIGRGKYGKVFLATDKQTSERVAIKRLRVD-PKE
.. . .|. | || |. | ||.| | ||.||| ..  ||
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKE
Kinase CRK7_e.AA TyrKc 20-159 10 0.000339 -154.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-159
Range on HMM: 1-280/280
Sequence Identity: 10% (32 aa)

YVAVESIGRGKYGKVFLATDKQTSERVAIKRLRVDPKEATLKVREAGGELRDVPASIAIEIKVLRLL--NNDHVVKLLDVIYAA-------TDIFLVFEY
 .  . .|.| .|.|...| |   . ||.| |. |                   . .  |..... |  .....|.|. |.            ...|.||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY

MKH-DLCGLIHRHK--FSAPEIKCYLKQILEGLHYCHLNGVMHRD-------------------------------------IKS----SSR--------
|.| ||   ...|.  .. ..   .  || .|  | | ... |||                                     ...    ...        
MPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

---------------------------------------------------------------------------------------------------T
                                                                                                    
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CRK7_e.AA Pkinase_Tyr 20-52 29 0.00202 12.21 Pfam 1-37 (270) Show / Hide 
Range on Protein: 20-52
Range on HMM: 1-37/270
Sequence Identity: 29% (11 aa)

YVAVESIGRGKYGKVFLATDK----QTSERVAIKRLR
 .  . .|.| .|.|...| |    .|   ||.| |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK
Kinase CRK7_e.AA Pkinase_Tyr 79-153 25 0.052799 7.41 Pfam 53-137 (270) Show / Hide 
Range on Protein: 79-153
Range on HMM: 53-137/270
Sequence Identity: 25% (22 aa)

EIKVLRLL-NNDHVVKLLDVIY-AATD--IFLVFEYMKH-DLCGLIHRH-----KFSAPEIKCYLKQILEGLHYCHLNGVMHRDI
|.|... | .....|.|. |..       |..|.|||.| ||    ..|     ... ... ..  || .|. | . ..  |||.
EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL