Gene YAK_b (S.moellendorffii)

YAK_b

Species: S.moellendorffii
Alias: YAK_b
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: YAK

Sequence

Name Sequence Type Origin Length Description Download
YAK_b.AA Protein None 650 None Fasta, JSON
YAK_b.NA RNA None 1953 None Fasta, JSON
YAK_b.kin_dom Protein Kinase Domain None 172 None Fasta, JSON

Protein domain

Protein domains of YAK_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase YAK_b.AA YAK 63-227 55 6.6e-86 291.7 In-house 1-167 (347) Show / Hide 
Range on Protein: 63-227
Range on HMM: 1-167/347
Sequence Identity: 55% (93 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQH---HIVRILDWFLFEQHLCIAFELLSHNLYELIKVNRH
|.|  |||||||||||||     |  .||||||| .|| |||  || ||..||   ||.| .   ||.|..| | .  |.|. ||.|| ||||..| |. 
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRTVYKYIQ
.| |  | | .||||||.. || |. .||||||||||.|     . |||.|||||.| | ..||.|||
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCK-PNKPEIKIIDFGSSCQEKKMVYTYIQ
Kinase YAK_b.AA DYRK 63-227 50 1.5e-81 277.25 In-house 1-166 (320) Show / Hide 
Range on Protein: 63-227
Range on HMM: 1-166/320
Sequence Identity: 50% (84 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVNRHRGI
| . |..|.|.||||||||  . | .||.|.|.|......||. ||.||. ||.  |||...|.|...| | . .|||| ||||| ||||..| |. .| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ-DPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-SLHLLRIFTKQILDSLGVLRNA-GVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRTVYKYIQ
 || | | |..|||..| .| .    ||||||||||.|    .  .||.|||||.| ||...|.|||
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQ
Kinase YAK_b.AA DYRK2 63-227 50 6.4e-71 229.78 In-house 1-164 (318) Show / Hide 
Range on Protein: 63-227
Range on HMM: 1-164/318
Sequence Identity: 50% (84 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVNRHRGI
| ..|..|.| |||||||     . .||.|.| |.  . .||..||.||. . |  |.||.. .|..|| | |  |.||.||||| ||||.|| |   |.
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHI-RRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

SLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHR-TVYKYIQ
|| | | |...|| .|  |.   .||||||||||||    .|| ||.||||| | ||.  .| |||
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSG-IKVIDFGSSCFEHQYRIYTYIQ
Kinase YAK_b.AA CMGC 63-227 24 4.4e-60 195.74 In-house 1-287 (513) Show / Hide 
Range on Protein: 63-227
Range on HMM: 1-287/513
Sequence Identity: 24% (71 aa)

YVVKEMLGQGTFGQVVKCWS--------------DRENGYVAVKVIKNQPAYYQQAL-------------VEIEILKMLN---------RDFDPDNQHH-
| . . .|.||.|.|.||.                . | .||.| |||.. |  ||.              ||.|||.||         || ||||.|| 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

-IVRILDWFLFEQ-----------------HLCIAFELLSHNLYELIKVNRH--------------------------RGISLHLLRIFTKQILDSLG--
 ||...|.| ...                 ||.. ||.. |.||..|| |..                          . ... . | ...||| .|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

VLRNAG--VIHCDLKPENILLSTS-----------------LKSGEIKLIDFGSACLEHRT------------------------VYKYIQ
 .  ..  .||.||||||||..                   .|.|..|..|||.|. .|                           . |..
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVV
Kinase YAK_b.AA DYRK1 63-227 44 9.6e-55 188.19 In-house 1-165 (321) Show / Hide 
Range on Protein: 63-227
Range on HMM: 1-165/321
Sequence Identity: 44% (75 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVNRHRGI
| .  ..|.| |||||| .   |  |||.|.|||. ..|.||..|| .| ..|.  |.... .||..   | |  |||. ||||| |||.|..    ||.
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKH-DKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

SLHLLRIFTKQILDSLGVLR--NAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRTVYKYIQ
|| | | | .|.. .|  .      .||||||||||||  . .|  ||.|||||.|   . .|.|||
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRS-AIKIIDFGSSCQLGQRIYQYIQ
Kinase YAK_b.AA CLK 63-201 36 2.5e-53 157.88 In-house 1-150 (350) Show / Hide 
Range on Protein: 63-201
Range on HMM: 1-150/350
Sequence Identity: 36% (55 aa)

YVVKEMLGQGTFGQVVKCWSDRENG--YVAVKVIKNQPAYYQQALVEIE-ILKMLNRDFDPDNQHH--IVRILDWFLF-EQHLCIAFELLSHNLYELIKV
|...  ||.|||| ||.|| |..||  |||.|.|.|   |  .| |||. |.| .|   ||.|..   .....||| .   | || |||.  ..|...| 
YEIVCTLGEGTFGKVVECW-DHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKS

NR------HRGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTS
|.       ..  ..  | ...|.. ... |   . .| |||||||... |
NNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDS
Kinase YAK_b.AA HIPK 63-227 41 2.6e-47 146.75 In-house 1-165 (329) Show / Hide 
Range on Protein: 63-227
Range on HMM: 1-165/329
Sequence Identity: 41% (70 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVNRHRGI
| | |.||.||||||||||    |  ||.|..||.| |  |  .|..||. | .. ..| . |.|| .. |  ..| |. ||.|  |||.  | |.   .
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCL-SQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPL

SLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSG-EIKLIDFGSACLEHRTVYK-YIQ
 |. .|  ..|.|  |  |.. |.|| |||||||.|    .    .| ||||||    ..| . |.|
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQ
Kinase YAK_b.AA PRP4 63-215 36 1.8e-37 130.84 In-house 1-154 (320) Show / Hide 
Range on Protein: 63-215
Range on HMM: 1-154/320
Sequence Identity: 36% (57 aa)

YVVKEMLGQGTFGQVVKCW-SDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRD-FDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVN-RH
| |    ||| |. |..|   .| |  ||.|.| | .  ..  | |.|||. ||    |..   |.||. . | . ||.|. || .| || |..|   . 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

RGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSA
 | .|   | ...|..  |  | . . .| |.|| ||| . | .   .|..|||||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNT--LKMCDFGSA
Kinase YAK_b.AA S_TKc 63-317 22 2.4e-36 127.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 63-317
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSH---NLYELIKVNRH
| . . .|.|.||.| ||.  . . .||.|.||      .... ||.|||.        .  .||...|.|   .||.. .|....   .|...|| ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

RG----ISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRTVYKYIQFCNPSCYCEFTSLCA---------LQRE
.|    ..    | ...||.. |  . . |.||.|||||||||..     .||..|||.|..                    |..|          |   
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL---

AKEP---------------LVGKSYFRHTKLEDIISKYPYKSSLSAEEQEAERQRRLSFLDFLRGLVRFDPKSRWTPHQVCL-------LFFI
   .               |.|.  |.   .. .. |                    ...||.|.. ..||. |.|  ..           ..
GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase YAK_b.AA DyrkP 63-227 37 4.6e-34 109.09 In-house 1-167 (323) Show / Hide 
Range on Protein: 63-227
Range on HMM: 1-167/323
Sequence Identity: 37% (63 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVNR----
| . | ||   | . ..|     |  . .|.| |   |. |.. || .|. .|   | | .  ..|. |.|    || |  |||  ||||  | ||    
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEK-NVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQ

HRGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRTVYKYIQ
 |   .  |   |.||| .|  .    .|||||||||||.    | ...|.|||||.|  |  .  |.|
QRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPK-CQVKIIDFGSSCFIHDHLSSYVQ
Kinase YAK_b.AA ULK 63-215 28 1.2e-29 100.65 In-house 1-189 (329) Show / Hide 
Range on Protein: 63-215
Range on HMM: 1-189/329
Sequence Identity: 28% (55 aa)

YVVKEMLGQGTFGQVVKCW-SDRE---NGYVAVKVIK-----NQP-----AYYQQALV-EIEILKMLN---RDFDPDNQH---HIVRILDWFLFEQH--L
|.....||.|.||.| |    ...   | .||.|.|      ...      |  | |  ||.|.|.|.   |     ...   .||. .|||   .|  .
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNR-----HKNHHPNIVKLYDWFETSNHNNI

CIAFELLSH-NLYELIKVNRH--------RGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTS----------LKSGEIKLIDFGSA
 | .|.  . .| ..|| |..        . .|    ..| ||||  .  |.  ..||.|.||.|||..              .| .|. ||| |
YIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFA
Kinase YAK_b.AA Pkinase 63-224 30 2.2e-29 104.97 Pfam 1-169 (293) Show / Hide 
Range on Protein: 63-224
Range on HMM: 1-169/293
Sequence Identity: 30% (54 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQ---ALV--EIEILKMLNRDFDPDNQH-HIVRILDWFLFEQHLCIAFELLSH-----NLY
|.... .|.|.||.| ||    ..  ||||.|| . .  ..   ..   ||.|.|.||        | .|||..|||  ..|... .|.. .      |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

ELIKVNRHRGI--SLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLS--TSLKSGEIKLIDFGSAC---LEHRTVYK
..|.. ||...  | . .. . .|||  |  . . |.||.||||||||..    ...  .|..|||.|.   . . . ..
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MT
Kinase YAK_b.AA YAK 254-317 29 2.2e-12 37.96 In-house 284-347 (347) Show / Hide 
Range on Protein: 254-317
Range on HMM: 284-347/347
Sequence Identity: 29% (19 aa)

KSYFRHTKLEDIISKYPYKSSLSAEEQEAERQRRLSFLDFLRGLVRFDPKSRWTPHQVCLLFFI
| ||    | ||.  . .| . . .  . ....|  |.||. .|   .|. ||.| |  .  ||
KTYFQYKCLNDIKNYMYFKQFMRNQDDTKNNRHRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase YAK_b.AA TyrKc 63-297 15 5.8e-09 -77.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 63-297
Range on HMM: 1-280/280
Sequence Identity: 15% (47 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKML--NRDFDPDNQHHIVRILDWFLFE-------QHLCIAFELLSH-NLYE
 . ...|| | ||.|.|.  .     ||||..|.     .  . |..|...|  . .       .|||..   . .       . |.| .|. .| .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LIKVNRHRGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRT-------VYKYIQF---CNP-----------
 .. .|.. ...  |  |  || .    |   ..|| ||   |.|..  .    .|  ||| .   .          |.  .    ..            
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

SCYCEFTS-------------LCALQREAKEPLVGKSYFRH-----TKLEDIISKYPYKSSLSAEEQ---------------------EAERQRRLSFLD
  |..||.             .. .         |..          . ...| .      .   .                      ...   | .| .
INYGKFTTKSDVWSFGVCMWEIFTY---------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

FLRGL
  . .
IHECF
Kinase YAK_b.AA DYRK 276-317 21 0.000368 11.77 In-house 280-320 (320) Show / Hide 
Range on Protein: 276-317
Range on HMM: 280-320/320
Sequence Identity: 21% (9 aa)

SAEEQEAERQRRLSFLDFLRGLVRFDPKSRWTPHQVCLLFFI
.  . . . . .. |.||....  .||..|.|| |     ..
RNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase YAK_b.AA CMGC 290-317 25 0.001191 6.84 In-house 486-513 (513) Show / Hide 
Range on Protein: 290-317
Range on HMM: 486-513/513
Sequence Identity: 25% (7 aa)

FLDFLRGLVRFDPKSRWTPHQVCLLFFI
..|.| .. ..||. |.|. | .   ..
AIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase YAK_b.AA CLK 202-215 57 0.003883 4.45 In-house 181-194 (350) Show / Hide 
Range on Protein: 202-215
Range on HMM: 181-194/350
Sequence Identity: 57% (8 aa)

LKSGEIKLIDFGSA
.|. .|..||||||
VKNTHICVIDFGSA
Kinase YAK_b.AA DYRK1 288-317 33 0.01856 3.87 In-house 292-321 (321) Show / Hide 
Range on Protein: 288-317
Range on HMM: 292-321/321
Sequence Identity: 33% (10 aa)

LSFLDFLRGLVRFDPKSRWTPHQVCLLFFI
| | | .. ....|||.| || ..    |.
LKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase YAK_b.AA Pkinase 251-315 14 0.023806 9.39 Pfam 206-293 (293) Show / Hide 
Range on Protein: 251-315
Range on HMM: 206-293/293
Sequence Identity: 14% (13 aa)

LVGKSYFRHT----KLEDIISKYPYKSSLSAEEQEAERQRR------------------LSFLDFLRGLVRFDPKSRWTPHQVCLL--F
| |.  |..     .  | . ..  . .   .... .  ..                   ...||.... ..|||.|.|..|..    |
LCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase YAK_b.AA YAK 329-338 60 0.096237 1.25 In-house 338-347 (347) Show / Hide 
Range on Protein: 329-338
Range on HMM: 338-347/347
Sequence Identity: 60% (6 aa)

AFQAAQHPFV
. || ||||.
PMQAMQHPFI
Kinase YAK_b.AA DYRK 329-338 50 0.201738 1.42 In-house 311-320 (320) Show / Hide 
Range on Protein: 329-338
Range on HMM: 311-320/320
Sequence Identity: 50% (5 aa)

AFQAAQHPFV
. || |||..
PSQALQHPWF