Gene YAK_a (S.moellendorffii)

YAK_a

Species: S.moellendorffii
Alias: YAK_a
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: YAK

Sequence

Name Sequence Type Origin Length Description Download
YAK_a.AA Protein None 456 None Fasta, JSON
YAK_a.NA RNA None 1371 None Fasta, JSON
YAK_a.kin_dom Protein Kinase Domain None 337 None Fasta, JSON

Protein domain

Protein domains of YAK_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase YAK_a.AA YAK 66-402 45 3.4e-150 505.25 In-house 1-347 (347) Show / Hide 
Range on Protein: 66-402
Range on HMM: 1-347/347
Sequence Identity: 45% (159 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQH---HIVRILDWFLFEQHLCIAFELLSHNLYELIKVNRH
|.|  |||||||||||||     |  .||||||| .|| |||  || ||..||   ||.| .   ||.|..| | .  |.|. ||.|| ||||..| |. 
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRTVYKYIQSRYYRSPEVVLGHPYTTAIDMWSLGCVAAELF
.| |  | | .||||||.. || |. .||||||||||.|     . |||.|||||.| | ..||.|||.|.|||||.... .|.|.||||||||. ||||
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCK-PNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELF

LGLPLFSGESEYDLLRRMIDTLGCQPPDQLLRDSANTSKYFKTVSA---------APPSSGGMAVYQFLTVSEVKARESKEPLVGKSYFRHTKLEDIISK
||||.| | |||. . | ||.||  ||  ..       |||.                  |    | | |  .    |    .  | ||    | ||.  
LGLPIFPGNSEYNQIKRIIDMLGY-PPSWMIDQGRFKNKYFHCHDGSNSDDNNNNNNNNNGKPYYYIFKTKQDYQIDEKIQLKESKTYFQYKCLNDIKNY

YPYKSSLSAEEQEAERQRRLSFLDFLRGLVRFDPKSRWTPHQAAQHPFV
. .| . . .  . ....|  |.||. .|   .|. ||.| || ||||.
MYFKQFMRNQDDTKNNRHRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase YAK_a.AA DYRK 66-402 41 1.1e-143 483.63 In-house 1-320 (320) Show / Hide 
Range on Protein: 66-402
Range on HMM: 1-320/320
Sequence Identity: 41% (140 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVNRHRGI
| . |..|.|.||||||||  . | .||.|.|.|......||. ||.||. ||.  |||...|.|...| | . .|||| ||||| ||||..| |. .| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ-DPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-SLHLLRIFTKQILDSLGVLRNA-GVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRTVYKYIQSRYYRSPEVVLGHPYTTAIDMWSLGCVAAELFL
 || | | |..|||..| .| .    ||||||||||.|    .  .||.|||||.| ||...|.|||||.||.||| ||.|| .|||||||||. ||||.
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

GLPLFSGESEYDLLRRMIDTLGCQPPDQLLRDS--ANTSKYFKTVSAAPPSSGGMAVYQFLTVSEVKARESKEPLVGKSYFRHTKLEDIISKYPYKSSLS
| |||.||.|||.|......||  ||  ... .    . |.|.                 .. .|.. .. |   ... |.   . .. . .. .  . .
GWPLFPGENEYDQLACIMEVLGM-PPKWMIDKGRCRRKHKFFDC----------------FMYCECDEWT-KQNKITDHYMTPKCHPTKR-GQRRPPGRR

AEEQEAERQRRLSFLDFLRGLVRFDPKSRWTPHQAAQHPFV
  . . . . .. |.||....  .||..|.|| || |||..
NWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase YAK_a.AA DYRK2 66-303 49 3.9e-108 352.8 In-house 1-240 (318) Show / Hide 
Range on Protein: 66-303
Range on HMM: 1-240/318
Sequence Identity: 49% (121 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVNRHRGI
| ..|..|.| |||||||     . .||.|.| |.  . .||..||.||. . |  |.||.. .|..|| | |  |.||.||||| ||||.|| |   |.
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHI-RRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

SLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHR-TVYKYIQSRYYRSPEVVLGHPYTTAIDMWSLGCVAAELFLG
|| | | |...|| .|  |.   .||||||||||||    .|| ||.||||| | ||.  .| |||||.||.||| ||..| .||||||.||..|||. |
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSG-IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

LPLFSGESEYDLLRRMIDTLGCQPPDQLLRDS----ANTSKYF
 ||| || | | .  |.  ||  || ...  .        |||
YPLFPGENENDQFACMMEVLGM-PPKKFFDTWFYIHCFRRKYF
Kinase YAK_a.AA CMGC 66-285 26 1.5e-94 311.08 In-house 1-371 (513) Show / Hide 
Range on Protein: 66-285
Range on HMM: 1-371/513
Sequence Identity: 26% (101 aa)

YVVKEMLGQGTFGQVVKCWS--------------DRENGYVAVKVIKNQPAYYQQAL-------------VEIEILKMLN---------RDFDPDNQHH-
| . . .|.||.|.|.||.                . | .||.| |||.. |  ||.              ||.|||.||         || ||||.|| 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

-IVRILDWFLFEQ-----------------HLCIAFELLSHNLYELIKVNRH--------------------------RGISLHLLRIFTKQILDSLG--
 ||...|.| ...                 ||.. ||.. |.||..|| |..                          . ... . | ...||| .|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

VLRNAG--VIHCDLKPENILLSTS-----------------LKSGEIKLIDFGSACLEHRT------------------------VYKYIQSRYYRSPEV
 .  ..  .||.||||||||..                   .|.|..|..|||.|. .|                           . |...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

VLGHP----------YTTAIDMWSLGCVAAELFLG--------LPLFSGESE-----------YDLLRRMIDTLG
 || .          |||.|||||.||. ||...|         ||| |.||           .| | .....||
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLG
Kinase YAK_a.AA DYRK1 66-304 46 9.6e-90 304.45 In-house 1-238 (321) Show / Hide 
Range on Protein: 66-304
Range on HMM: 1-238/321
Sequence Identity: 46% (111 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVNRHRGI
| .  ..|.| |||||| .   |  |||.|.|||. ..|.||..|| .| ..|.  |.... .||..   | |  |||. ||||| |||.|..    ||.
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKH-DKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

SLHLLRIFTKQILDSLGVLR--NAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRTVYKYIQSRYYRSPEVVLGHPYTTAIDMWSLGCVAAELFL
|| | | | .|.. .|  .      .||||||||||||  . .|  ||.|||||.|   . .|.|||||.||||||.|| .| .|||||||||.  |.  
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRS-AIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHT

GLPLFSGESEYDLLRRMIDTLGCQPPDQLLRDSANTSKYFK
| ||||| .| | . .... ||  ||....  .  . |||.
GEPLFSGSNEVDQMNKIVEVLGM-PPKHMIDQAPKAHKYFE
Kinase YAK_a.AA HIPK 66-402 36 1.3e-85 269.5 In-house 1-329 (329) Show / Hide 
Range on Protein: 66-402
Range on HMM: 1-329/329
Sequence Identity: 36% (123 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVNRHRGI
| | |.||.||||||||||    |  ||.|..||.| |  |  .|..||. | .. ..| . |.|| .. |  ..| |. ||.|  |||.  | |.   .
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCL-SQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPL

SLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSG-EIKLIDFGSACLEHRTVYK-YIQSRYYRSPEVVLGHPYTTAIDMWSLGCVAAELFL
 |. .|  ..|.|  |  |.. |.|| |||||||.|    .    .| ||||||    ..| . |.|||||| ||..|| |.  ..|||||||| |||||
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFL

GLPLFSGESEYDLLRRMIDTLGCQPPDQLLRDSANTSKYFKTVSAAPPSSGGMAVYQFLTVSEVKARESKEPLVGKSYFRHTKLEDIISKYPYKSSLSAE
| ||. | .|||. | .. | .  | ..||     . ..|. .        .  ...  .. |  .  |   .  . |       | ...  .   .  .
GWPLYPGADEYDQIRYICQTQH-LPHEHLLHAACKKHRFFDRD-----KQSKFRPWRLKHIEEHEQQTSVKSKEARKYI--FNCLDDMPEVNMLVDPERQ

EQEAERQRRLSFLDFLRGLVRFDPKSRWTPHQAAQHPFV
.  .|.  | .| . |. ..  |...| || .| .||||
DYRVEKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase YAK_a.AA S_TKc 66-402 21 4.7e-81 276.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 66-402
Range on HMM: 1-231/231
Sequence Identity: 21% (76 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSH---NLYELIKVNRH
| . . .|.|.||.| ||.  . . .||.|.||      .... ||.|||.        .  .||...|.|   .||.. .|....   .|...|| ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

RG----ISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRTVYKYIQSRYYRSPEVVLGHPYTT-AIDMWSLGCV
.|    ..    | ...||.. |  . . |.||.|||||||||..     .||..|||.|..     . .. ...|..|||.   .|.. ..|.||.||.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

AAELFLGLPLFSGESEYDLLRRMIDTLGCQPPDQLLRDSANTSKYFKTVSAAPPSSGGMAVYQFLTVSEVKARESKEPLVGKSYFRHTKLEDIISKYPYK
 .|.. | |.|.   .. .....                                                                             
LYEMLCGYPPFP--QMQMMFKKIG----------------------------------------------------------------------------

SSLSAEEQEAERQRRLSFLDFLRGLVRFDPKSRWTPHQAAQ-------HPFV
                ...||.|.. ..||. |.|  .| |       ||..
--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase YAK_a.AA PRP4 66-303 35 1.9e-60 207.16 In-house 1-239 (320) Show / Hide 
Range on Protein: 66-303
Range on HMM: 1-239/320
Sequence Identity: 35% (86 aa)

YVVKEMLGQGTFGQVVKCW-SDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRD-FDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVN-RH
| |    ||| |. |..|   .| |  ||.|.| | .  ..  | |.|||. ||    |..   |.||. . | . ||.|. || .| || |..|   . 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

RGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSAC-LEHRTVYKYIQSRYYRSPEVVLGHPYTTAIDMWSLGCVAAEL
 | .|   | ...|..  |  | . . .| |.|| ||| . | .   .|..|||||   .   . .| .||.||.||...||||  .||||| ||  .||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNT--LKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYEL

FLGLPLFSGESEYDLLRRMIDTLGCQPPDQLLRDSANTSKYF
. |  .|.| .  . |. . |  |   |  ..| .   ...|
YTGKIMFPGKTNNHMLKLFMDYKGKM-PNKMIRKGQFKDNHF
Kinase YAK_a.AA DyrkP 66-288 40 1.6e-55 181.02 In-house 1-225 (323) Show / Hide 
Range on Protein: 66-288
Range on HMM: 1-225/323
Sequence Identity: 40% (92 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFDPDNQHHIVRILDWFLFEQHLCIAFELLSHNLYELIKVNR----
| . | ||   | . ..|     |  . .|.| |   |. |.. || .|. .|   | | .  ..|. |.|    || |  |||  ||||  | ||    
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEK-NVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQ

HRGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRTVYKYIQSRYYRSPEVVLGHPYTTAIDMWSLGCVAAEL
 |   .  |   |.||| .|  .    .|||||||||||.    | ...|.|||||.|  |  .  |.||| || |||..|  |   ||||||||. |||
QRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPK-CQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAEL

FLGLPLFSGESEYDLLRRMIDTLGCQP
. |  ||  .    || |.|  .|  |
WTGNVLFQNDNIQGLLARVIGIIGPFP
Kinase YAK_a.AA CLK 66-204 36 2.5e-53 157.88 In-house 1-150 (350) Show / Hide 
Range on Protein: 66-204
Range on HMM: 1-150/350
Sequence Identity: 36% (55 aa)

YVVKEMLGQGTFGQVVKCWSDRENG--YVAVKVIKNQPAYYQQALVEIE-ILKMLNRDFDPDNQHH--IVRILDWFLF-EQHLCIAFELLSHNLYELIKV
|...  ||.|||| ||.|| |..||  |||.|.|.|   |  .| |||. |.| .|   ||.|..   .....||| .   | || |||.  ..|...| 
YEIVCTLGEGTFGKVVECW-DHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKS

NR------HRGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTS
|.       ..  ..  | ...|.. ... |   . .| |||||||... |
NNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDS
Kinase YAK_a.AA Pkinase 66-289 29 7.2e-50 176.79 Pfam 1-236 (293) Show / Hide 
Range on Protein: 66-289
Range on HMM: 1-236/293
Sequence Identity: 29% (73 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQ---ALV--EIEILKMLNRDFDPDNQH-HIVRILDWFLFEQHLCIAFELLSH-----NLY
|.... .|.|.||.| ||    ..  ||||.|| . .  ..   ..   ||.|.|.||        | .|||..|||  ..|... .|.. .      |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

ELIKVNRHRGI--SLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLS--TSLKSGEIKLIDFGSAC---LEHRTVYKYIQSRYYRSPEVVL-GHPYT
..|.. ||...  | . .. . .|||  |  . . |.||.||||||||..    ...  .|..|||.|.   . . . . .  ...|..|||.. | .|.
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYG

TAIDMWSLGCVAAELFLGLPLFSGE----SEYDLLRRMIDTLGCQPP
...||||.||. .|...| |.|.|.    . .| . ..  ..|....
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLH
Kinase YAK_a.AA CAMK 71-402 13 3e-47 149.87 In-house 1-425 (425) Show / Hide 
Range on Protein: 71-402
Range on HMM: 1-425/425
Sequence Identity: 13% (70 aa)

MLGQGTFGQVVKCWSDRENG------------YVAVKVIKNQ-----------------------------PAYYQQALVEIEILKMLNRDFDPDN---Q
 ||.|.||.| .|   . .|             ||.|.|. .                             |   .. . ||||.|.|.   . .|    
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQ---GIGNKLDH

HHIVRILDWFL------------FEQH--------LCIAF---ELLSHN-----LYELIKVNRH-------------RGISLHLLRIFTKQILDSLGVLR
 .|.......             . ..        ... .   |. |       |.. |. ...             . .. .  | . .||.. .  . 
PNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH

NAGVIHCDLKPENILLSTSLKS--------------GEIKLIDFGSACLEHR--------------------------TVYKYIQSRYYRS-PEVVLG--
. ...|.|||||||||... ..              . ||.|||| |.   .                            . .  . .| . |||..|  
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

------------HPYTTAIDMWSLGCVAAELFLGLPLFSGESEYDLLRRMIDTLGCQPPDQLLRDSANTSKYFKTVSAAPPSSGGMAVYQFLTVSEVKAR
             .|. ..||||.|..   .                                                                     
HCNMQNATDEEKPYYGPKCDMWSCGVILYIM---------------------------------------------------------------------

ESKEPLVGKSYFRHTKLEDIIS--------KYPYKSSLSAEEQ-EAERQRRLS----------------------FLDFLRGLVRFDPKSRWTPHQAAQH
     |.|.. |.. . ..|..        .  ..  .... . . .    .|                        |..|.. . ||. |.| .|. .|
-----LCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNH

PFV
|..
PWM
Kinase YAK_a.AA CLK 205-275 36 2.5e-19 53.96 In-house 181-254 (350) Show / Hide 
Range on Protein: 205-275
Range on HMM: 181-254/350
Sequence Identity: 36% (27 aa)

LKSGEIKLIDFGSAC---LEHRTVYKYIQSRYYRSPEVVLGHPYTTAIDMWSLGCVAAELFLGLPLFSGESEYD
.|. .|..||||||     .|   .  ...| || |||.|| .. .  | || ||.  || .|  || . .. .
VKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNRE
Kinase YAK_a.AA CMGC 375-402 39 4.9e-10 28.21 In-house 486-513 (513) Show / Hide 
Range on Protein: 375-402
Range on HMM: 486-513/513
Sequence Identity: 39% (11 aa)

FLDFLRGLVRFDPKSRWTPHQAAQHPFV
..|.| .. ..||. |.|. || |||. 
AIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase YAK_a.AA TyrKc 66-297 18 7.2e-10 -63.13 SMART 1-280 (280) Show / Hide 
Range on Protein: 66-297
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

YVVKEMLGQGTFGQVVKCWSDRENGYVAVKVIKNQPAYYQQALVEIEILKML--NRDFDPDNQHHIVRILDWFLFE-------QHLCIAFELLSH-NLYE
 . ...|| | ||.|.|.  .     ||||..|.     .  . |..|...|  . .       .|||..   . .       . |.| .|. .| .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LIKVNRHRGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKSGEIKLIDFGSACLEHRT-------VYKYI----QSR-----YYRSPEV
 .. .|.. ...  |  |  || .    |   ..|| ||   |.|..  .    .|  ||| .   .          |.      ...        .||.
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

VLGHPYTTAIDMWSLGCVAAELF-LGLPLFSG-----ESEYDLLRRMIDTLGCQPPDQ--------------------------------LLRDSA
   . .||. | || | .  |.| .| .  .|      | ......  .     .|.                                  ...  
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase YAK_a.AA DYRK2 374-402 41 1.7e-07 20.06 In-house 290-318 (318) Show / Hide 
Range on Protein: 374-402
Range on HMM: 290-318/318
Sequence Identity: 41% (12 aa)

SFLDFLRGLVRFDPKSRWTPHQAAQHPFV
.|.||..     ||..| || || .||. 
NFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase YAK_a.AA DYRK1 373-402 43 3e-06 17.24 In-house 292-321 (321) Show / Hide 
Range on Protein: 373-402
Range on HMM: 292-321/321
Sequence Identity: 43% (13 aa)

LSFLDFLRGLVRFDPKSRWTPHQAAQHPFV
| | | .. ....|||.| || .| ||.|.
LKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase YAK_a.AA Pkinase 336-402 16 1e-05 21.34 Pfam 206-293 (293) Show / Hide 
Range on Protein: 336-402
Range on HMM: 206-293/293
Sequence Identity: 16% (15 aa)

LVGKSYFRHT----KLEDIISKYPYKSSLSAEEQEAERQRR------------------LSFLDFLRGLVRFDPKSRWTPHQAAQHPFV
| |.  |..     .  | . ..  . .   .... .  ..                   ...||.... ..|||.|.|..|. |||..
LCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase YAK_a.AA PRP4 375-402 42 3e-05 15.28 In-house 293-320 (320) Show / Hide 
Range on Protein: 375-402
Range on HMM: 293-320/320
Sequence Identity: 42% (12 aa)

FLDFLRGLVRFDPKSRWTPHQAAQHPFV
| |.| ..   ||| | |. .| .|||.
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase YAK_a.AA CLK 374-402 37 7.5e-05 9.69 In-house 322-350 (350) Show / Hide 
Range on Protein: 374-402
Range on HMM: 322-350/350
Sequence Identity: 37% (11 aa)

SFLDFLRGLVRFDPKSRWTPHQAAQHPFV
.. | .| .  .||  | |  .| |||| 
QLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase YAK_a.AA DyrkP 375-402 39 0.001026 7.35 In-house 296-323 (323) Show / Hide 
Range on Protein: 375-402
Range on HMM: 296-323/323
Sequence Identity: 39% (11 aa)

FLDFLRGLVRFDPKSRWTPHQAAQHPFV
|.|| | ..  |   | |   | |||..
FIDFVRQCLQIDFTRRPTAKEALQHPWF