ERK-Un

Species: S.moellendorffii
Alias: ERK-Un
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
ERK-Un.AA Protein None 381 None Fasta, JSON
ERK-Un.NA RNA None 1146 None Fasta, JSON
ERK-Un.kin_dom Protein Kinase Domain None 275 None Fasta, JSON

Protein domain

Protein domains of ERK-Un.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc ERK-Un.AA S_TKc 93-367 26 4.3e-73 250.05 SMART 1-231 (231) Show / Hide
Range on Protein: 93-367
Range on HMM: 1-231/231
Sequence Identity: 26% (78 aa)

YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLREVCIMRRLSHRYVITLTDVFISMSMEVSGGIDLYIATEFADG--GDMYHLREP
| ....||.|..| |.....      ||.|..          ....||. |...  | ....| ||| .         .||. .|..||  ||.... . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKK

---------LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSA-EEVVTPSYRAPEVIMSRGQYSS-SIDIWSLGCIFWV
         ... |..|.|.|.. .. |.|| .. ||||| |||||     .|||||||.|     ..|| |.||||.    .|.  ..|.||.|||.. 
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

SVS-----SNDITILNLDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALS-------HIYV
 ..     .      .....|..||                                     ..||.|.. ..| ..| .| || |||        | ..
MLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF





Pkinase ERK-Un.AA Pkinase 93-367 26 4.1e-68 237.38 Pfam 1-293 (293) Show / Hide
Range on Protein: 93-367
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLR--EVCIMRRLSHRYVITLTDVFISMSMEVSGGIDLYIATEFADGG----DMY-
| ... |||||.| |.....   . .||.|..  .   .   .. .|  |..||.||.| ....| |.| .       . ..|. .|...||    | . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-------KDHIYMVMEYCEGGLYVMDLFD

----HLREPL--TPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSV----KICDFGLSRSA-------EEVVTPSYRAPEVIMSRGQYSSSI
    . . ..  .....|| |.|.| |. |.||... |||||.||||.  .. .    |||||||.. .         ..|| |.|||||...  |....
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNSMTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSLGCIFWVSVS-----SND----ITILNLDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAE
|.||.|||..  ..     ...      .  . .|... |.|  .|..   |.|... ..| . .    .. .  ....|..|.. ..|...| .|.|||
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

EALSHIYV
..| | ..
QILQHPWF

Kinase ERK-Un.AA CMGC 93-277 22 2.2e-58 190.06 In-house 1-325 (513) Show / Hide
Range on Protein: 93-277
Range on HMM: 1-325/513
Sequence Identity: 22% (72 aa)

YLLHEHIGSGSYGDVCRATD--------------CQASLTVALKRVGDVLCCPLLAK----------RVLREVCIMRRLS-----------------HRY
|   . ||.|.|| |....|              ..    ||.|..  .   .  ||          | |||. |...|.                 | .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VITLTDVFISMSMEVSGGI----------DLYIATEFADGGDMYHLRE-----------PLTPEH------------VKFLM------WQLLTGMS--YI
...| |.| .  .. ..            .||. .|. |      ...           ||.. |            .|..|      .|.|.|.   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSCR--VWHRDLKSENILLMAD--------------------MSVKICDFGLSR-----------------------------SAEEVVTPSYRAPEVIM
|| .  . ||||| ||||.  .                    . .|||||||.|                               ..|||  |||||...
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SRGQYS---------SSIDIWSLGCIF
. ..|.         ..||.||.||||
GWKHYTNHNYSMHYTTPIDMWSVGCIF

Kinase ERK-Un.AA MAPK 93-277 33 2.5e-55 189.77 In-house 1-224 (328) Show / Hide
Range on Protein: 93-277
Range on HMM: 1-224/328
Sequence Identity: 33% (75 aa)

YLLHEHIGSGSYGDVCRATDCQ------ASLTVALKRVGDVLCCPLLAKRVLREVCIMRRL-SHRYVITLTDVFIS-MSME--VSGG--IDLYIATEFAD
| . . ||.|.|| || |.|           .||.|.. ..   |...||..||. ..|..  |  .| | |.|   |. .   | .   |.|| .|. .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQ-DDQNSLEEFNDIYIVMELME

GGDMYHLRE---PLTPEHVKFLMWQLLTG--MSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSAEE----------------------VVTPSYR
  |.... .   ||. .|....|.|.| |  . |||| .| ||||| .|||.  .  .|||||||.||..                       |.|  ||
-TDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYR

APEVIMSR--GQYSSSIDIWSLGCIF
|||.....    |. ..|.||.||||
APEIMLNWIWMHYTKAVDMWSVGCIF

Kinase ERK-Un.AA ERK7 93-367 33 3e-55 187.27 In-house 1-292 (292) Show / Hide
Range on Protein: 93-367
Range on HMM: 1-292/292
Sequence Identity: 33% (99 aa)

YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLREVCIMRRLS-HRYVITLTDVFISMSMEVSGGIDLYIATEFADGGDMYHLR--E
|.... .| | || | .|.| ..  .||||.. |    .  | |  ||. ... .  |  .| | .|.       .   |.|.. || .       |  .
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI-----RADNDRDIYLVFEFMETDLHAVIRKGN

PLTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRS---AEE-----------VVTPSYRAPEVIMSRGQYSSSIDIWSLGC
 |   |... |.|||  . |.|| .| |||||  |||| ..  ||.||||| ||    ||           | |  |||||. ..  .|   .| ||.||
ILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGC

IFWVSVSSNDI-----TILNLDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV
|    .    .     |.  .. | ..|. |   |||.. |.   . |.... . |   .|..    ..|.||| |.|.||| .| |||.||.| ||
ILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV

Kinase ERK-Un.AA ERK1 93-367 36 1.3e-52 181.07 In-house 1-289 (289) Show / Hide
Range on Protein: 93-367
Range on HMM: 1-289/289
Sequence Identity: 36% (108 aa)

YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLREVCIMRRLSHRYVITLTDVFISMSMEVSGGIDLYIATEFADGGDMYHL--REP
|.  . || | || || | |      ||.|..          .| |||. |. |  |  .| . |.  . ..|     |.||  .  .  |.| |    .
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQM--RDVYIVQCLME-TDLYKLLKTQH

LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSA-----------EEVVTPSYRAPEVIMSRGQYSSSIDIWSLGCIFWV
|  .|. . ..|.| |. ||||  | |||||  |.||     .||||||| | |           | | |  |||||...    |  |||||| |||   
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE

SVSSNDIT-----ILNLDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV
 .|   |      .  |  |  |.| |   |.. .  |  |.||. || . .   ..|    |. ||||| .||.||| .| | |||| | |.
MLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL

Kinase ERK-Un.AA ERK5 93-367 33 2.2e-49 170.37 In-house 1-295 (295) Show / Hide
Range on Protein: 93-367
Range on HMM: 1-295/295
Sequence Identity: 33% (98 aa)

YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLREVCIMRRLSHRYVITLTDVFISMSMEVSGGIDLYIATEF--ADGGDMYHLREP
|   |.|| | || || |   .    ||.|..         ||| .||. |.|   |  .| . |.        |   | |.  .   .|   . |   |
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPK-VPYSEMKDVYVVFDLMESDLHQIIHSNQP

LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSR--SA-----------EEVVTPSYRAPEVIMSRGQYSSSIDIWSLGCIF
.| ||... ..|.| |. |.||  | |||||  |.|      .|| |||. |  .            | | |  |||||...|  .|   ||.|| ||||
FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIF

WVSVSSNDI-----TILNLDVIFNVIGTPGWSDIESVPSESWRSYLKH-LPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV
   ..   .      |  |..|  |.|.|    |..| ..  . |... .| |     |..    |. ||||| ||| | |  | |. .|| | ..
GEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL

Kinase ERK-Un.AA CAMK 98-276 18 3.4e-47 149.71 In-house 1-323 (425) Show / Hide
Range on Protein: 98-276
Range on HMM: 1-323/425
Sequence Identity: 18% (61 aa)

HIGSGSYGDVCRATDCQAS------------LTVALKR-------------------VGDVLCC-------PLLAKRVLREVCIMRRLS-------HRYV
 .|.||.| | .... .                || |                    . .  |.       |   |.|.||..||..|.       |. .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLTDVFISMSM--------EVSG-----GIDLYIAT---EFADGG----D-MYHLREP-----------------LTPEHVKFLMWQLLTGMSYIHSCR
| | .|. ...           |        ..|. .   |...||    |   ...|                  .| . ......|.. .. |.||. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VWHRDLKSENILLMADM-----------------SVKICDFGLSRSAEEVV-------------------------------TPSYRA-PEVIMS-----
. ||||| |||||  ..                  .||.|||...  ..                                 ||.| | |||. .     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------RGQYSSSIDIWSLGCI
        .  |. ..|.||.|.|
MQNATDEEKPYYGPKCDMWSCGVI

Kinase ERK-Un.AA p38 93-276 35 2.1e-45 153.04 In-house 1-193 (289) Show / Hide
Range on Protein: 93-276
Range on HMM: 1-193/289
Sequence Identity: 35% (69 aa)

YLLHEHIGSGSYGDVCRATDCQASLT---VALKRVGDVLCCPLLAKRVLREVCIMRRLSHRYVITLTDVFISMSMEVSGGIDLYIATEFADGGDMYHLRE
|   ...|||.|| || | | . .     || |.       .. |||  ||.   . . |. || | |||     ...   | |. |.|..      .. 
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

P-LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSAEE-----VVTPSYRAPEVIMSRGQYSSSIDIWSLGCI
  |. .|..||  |.| |  ||||  . |||||  || .  |  ..| ||||.|....     |.|  |||||.. ....|   .||||.|||
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCI

Kinase ERK-Un.AA MAPK-Unclassified 93-246 36 1e-42 148.25 In-house 1-161 (575) Show / Hide
Range on Protein: 93-246
Range on HMM: 1-161/575
Sequence Identity: 36% (59 aa)

YLLHEHIGSGSYGDVCRATDCQA-SLTVALKRVGDVLCCPLLAKRVLREVCIMRRLSHRYVITLTDVFISMSMEVSG--GIDLYIATEFADG-----GDM
|.. . ||||.|| ||||.| .     || |.|  .   . ..||||||. | | |.|  .| ..|.|  .  | ..   .|.|| ...           
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIF--YNKELHNQEFDDIYIVMDYMQTSLFDLHQI

YHLRE-PLTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSAEE
.. .. ..  .|.. .. |.|.|. |.||  . |||||  |.|.  | ||.|||||.||| |.
IKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED

Kinase ERK-Un.AA CDK 138-277 34 6.4e-42 131.79 In-house 56-212 (284) Show / Hide
Range on Protein: 138-277
Range on HMM: 56-212/284
Sequence Identity: 34% (58 aa)

LREVCIMRRLSHRYVITLTDVFISMSMEVSGGID-----LYIATEFADGGDMYHLREPLTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMS
.||..... | | ....| ||.....|. .. .|     ||.  |..|  | ... .      .| .||||| |..|.|| .. |||||  |||.. . .
IREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFEYMDH-DLKKYMD------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGE

-----VKICDFGLSRSAE--------------EVVTPSYRAPEVIMSRGQYS--SSIDIWSLGCIF
     .|| ||||.|                 ||||  |||||. .   .||   .||.||.||||
VKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIF

Kinase ERK-Un.AA ERK 93-277 36 4.4e-39 136.16 In-house 1-207 (307) Show / Hide
Range on Protein: 93-277
Range on HMM: 1-207/307
Sequence Identity: 36% (76 aa)

YLLHEHIGSGSYGDVCRATDCQ-----ASLTVALKRVGDVLCCPLLAKRVLREVCIMRRLS-HRYVITLTDVFISMSMEVSGGIDLYIATEFADGGDMYH
| ... || |.|| || |.|        . .|| | . ..   |...|| |||  ..| .  |  .|.| |.... | |  .  |.|. .|. .  |.  
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE--QYNDIYCVEELME-TDLHQ

L---REPLTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSR----SAEE------------VVTPSYRAPEVIMSRGQYSSS
    . .|...|....|.|.| |. ||||  | |||||  |||.  .   |||||||.|    |..|            |.|  |||||.. |   |...
IINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKA

IDIWSLGCIF
.|||| ||||
MDIWSCGCIF

Kinase ERK-Un.AA MAPK 291-367 34 3.8e-20 66.16 In-house 244-328 (328) Show / Hide
Range on Protein: 291-367
Range on HMM: 244-328/328
Sequence Identity: 34% (29 aa)

LDVIFNVIGTPGWSDIESVP-SESWRSYLKHL---PGRVRNLTEQLLGY----VDQEALDLLFRMLAFNPGRRCTAEEALSHIYV
.  |..|.|||   .|. .. ||. |.|.. |   | . .   |...      .. .|.|||..||.|.| .| |.||||.| |.
WNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF

Kinase ERK-Un.AA CMGC 291-367 18 4.4e-15 45.1 In-house 363-513 (513) Show / Hide
Range on Protein: 291-367
Range on HMM: 363-513/513
Sequence Identity: 18% (28 aa)

LDVIFNVIGTP----------------GWSDIESVP--------------------SESWRSYLKH---LP-GRVRNLTEQLLG----------------
|. ||.|.|||                   ... ..                    ||. | |..    .|  . ......  .                
LFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNW

------------------YVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV
                    |..|.||| .|| ..| .| |||.||.| | 
IYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

Kinase ERK-Un.AA p38 291-367 35 1.1e-14 46.35 In-house 213-289 (289) Show / Hide
Range on Protein: 291-367
Range on HMM: 213-289/289
Sequence Identity: 35% (27 aa)

LDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV
|  | .|.|||    .. . ||. |.|.. .| . |   ....   .  |.||| .||   | .| |||||..| | 
LQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF

Kinase ERK-Un.AA TyrKc 93-365 20 3.7e-13 -9.97 SMART 1-280 (280) Show / Hide
Range on Protein: 93-365
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLREVCIMRRL--SHRYVITLTDVFISMS---MEVSGGIDLYIATEFADGGDMYHL
  | . .|.| .| |...|     ..|| | . .        .  .||  ||..|  .|  .. |  | .. .   |..     |.| .|....||  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEP---LMIVMEYMPHGDLKDY

R---EP-LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSAE---------EVVTP----SYR--------APEVIMSRG
    .| |....    .||   ||.|.|| .. ||||   |.|. ..  |||.||||||  .         .. ..    . .        |||.|   |
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG

QYSSSIDIWSLGCIFW--VSVSSNDITI-----LNLDVIFNVIGTPGWSDIESVP---SESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNP
 ...  |.|| |   |   .             .. . ... . . .  ..   .   |                          .|  ..  .  ...|
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------F-VCCPDEMYQIMKQCWHEDP

GRRCTAEEALSHI
  |.| .|  . .
EDRPTFSEIHECF

Kinase ERK-Un.AA ERK 291-367 36 1.1e-12 43.68 In-house 226-307 (307) Show / Hide
Range on Protein: 291-367
Range on HMM: 226-307/307
Sequence Identity: 36% (30 aa)

LDVIFNVIGTP-GWSDIESVPSESWRSYLKHLPG--RVRNLTEQLLGY--VDQEALDLLFRMLAFNPGRRCTAEEALSHIYV
.. ||..|||| .  |..  .||  . |.| ||   |     | .     .  .|.||| .||.|.|  | |.||.|.| | 
INRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF

Kinase ERK-Un.AA Pkinase_Tyr 93-242 28 4.4e-12 41.55 Pfam 1-159 (270) Show / Hide
Range on Protein: 93-242
Range on HMM: 1-159/270
Sequence Identity: 28% (47 aa)

YLLHEHIGSGSYGDVCRATDC----QASLTVALKRVGDVLCCPLLA---KRVLREVCIMRRL-SHRYVITLTDVFISMSMEVSGGID--LYIATEFADGG
  . . .|.|..|.|...|      .  ..|| | . .   .   .   .  .||. ||. | .|  .. |  | .      . |    .|| .|.. .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT------DQGEPNQIYIVMEYMPHG

DMY-HLREP------LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSR
|.. .||..      ||...     ||   ||.| .| .  ||||   |.|.  .. ||||||||.|
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR

Kinase ERK-Un.AA MAPK-Unclassified 247-277 58 8e-12 38.52 In-house 409-439 (575) Show / Hide
Range on Protein: 247-277
Range on HMM: 409-439/575
Sequence Identity: 58% (18 aa)

VVTPSYRAPEVIMSRGQYSSSIDIWSLGCIF
|||  ||||| ..| . |.  .||||.||||
VVTRWYRAPEIMLSMHEYDTQVDIWSIGCIF

Kinase ERK-Un.AA CDK 291-367 26 1.6e-11 32.97 In-house 234-284 (284) Show / Hide
Range on Protein: 291-367
Range on HMM: 234-284/284
Sequence Identity: 26% (21 aa)

LDVIFNVIGTPG---WSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV
|. ||...|||    | .... |                               ||| .||...| .|..||.||.| | 
LFKIFRICGTPTEDNWPGVTKLPDY-----------------------------DLLNKMLCYDPKKRISAEQALQHPYF

Kinase ERK-Un.AA CAMK 335-367 39 2e-09 25.79 In-house 393-425 (425) Show / Hide
Range on Protein: 335-367
Range on HMM: 393-425/425
Sequence Identity: 39% (13 aa)

YVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV
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FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase ERK-Un.AA MAPK-Unclassified 291-367 26 2.2e-09 29.57 In-house 489-575 (575) Show / Hide
Range on Protein: 291-367
Range on HMM: 489-575/575
Sequence Identity: 26% (23 aa)

LDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQ----------EALDLLFRMLAFNPGRRCTAEEALSHIYV
. .|| . |.|   |.  . . | | |.. .    .    .|  .             |..|..  ||.||| .| ||..||.| |.
IKMIFDYLGMPPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF

Kinase ERK-Un.AA CDK 93-124 40 7e-06 14.59 In-house 1-37 (284) Show / Hide
Range on Protein: 93-124
Range on HMM: 1-37/284
Sequence Identity: 40% (15 aa)

YLLHEHIGSGSYGDVCRATDCQAS-----LTVALKRV
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YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKI