Gene ERK5_a-2 (S.moellendorffii)

ERK5_a-2

Species: S.moellendorffii
Alias: ERK5_a-2
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
ERK5_a-2.AA Protein None 491 None Fasta, JSON
ERK5_a-2.NA RNA None 1476 None Fasta, JSON
ERK5_a-2.kin_dom Protein Kinase Domain None 309 None Fasta, JSON

Protein domain

Protein domains of ERK5_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK5_a-2.AA ERK 16-324 48 1.2e-155 523.37 In-house 1-307 (307) Show / Hide 
Range on Protein: 16-324
Range on HMM: 1-307/307
Sequence Identity: 48% (156 aa)

YKILEVIGKGSYGVVCSATDMH-----TGDKVAIKKINDIFEHVSDATRILREIKLLRLLR-HPDIVEIKHIMLPPSRREFKDIYVVFELMESDLHQVIK
|.|.. ||.|.|||||||.|       ||.||||||| ..|.|  ...|.||||||||... |. |. ...||.| |. ...|||.|.||||.||||.|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

ANDDLTPEHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLAR---VAFNDAPTAIFWTVSASNKGWTYLTLLFFKDYVATRWYRAP
    |...|.|.|.||.|..||||| |||.||||||.||| | .| ||||||||||   . ... ..                .  |...||||||||||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE---------------CNQNFMTEYVATRWYRAP

ELCGSFFSKYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTP-SAESVARVRNEKARRYLSGMRK--KTAIPFTQKFPNAD--PLALRLL
|.  | ..||| |.||||.|||||| | .|||||||. |||... .. .||| | | . .  .|.|. |.. . .  ....|.   ||||.  |.|. ||
EIMLS-WQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLL

ERLLAFDPKDRPTAEEALADPYF
|..|.|||..| |.||.|. |||
EKMLVFDPDKRITVEECLEHPYF
Kinase ERK5_a-2.AA MAPK 16-324 46 3e-155 522.06 In-house 1-328 (328) Show / Hide 
Range on Protein: 16-324
Range on HMM: 1-328/328
Sequence Identity: 46% (158 aa)

YKILEVIGKGSYGVVCSATDMH------TGDKVAIKKINDIFEHVSDATRILREIKLLRLL-RHPDIVEIKHIMLP------PSRREFKDIYVVFELMES
|.||. ||.|.|||||||.|        .|.||||||| . |... .. |..||||||| . .|. |. ...|. |      .|. ||.|||.|.||||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQVIKANDDLTPEHYQFFLYQLLRA--LKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVAFND---------APTAIFWTVSASNKGWTYLTL
||||.|| .. |. .| |.|.||.||.  ||||| ||| |||||| ||| | .| ||||||||||.. ..         . .  |               
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HC-F-Q------------K

LFFKDYVATRWYRAPELCGSF-FSKYTPAIDIWSIGCIFAEILT-GKPLFPGKNVVHQLDLMTDMLGTPSAESVARVR-NEKARRYLSGM---RKKTAIP
 .  .|||||||||||.  .    .|| |.|.||.|||||| || .|||||||. ..|. |....||||| | . ..  .|.|| |....   .|....|
MHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKP

FTQKFPN----ADPLALRLLERLLAFDPKDRPTAEEALADPYF
... |||    |.|.|. |||..|.|||..| |.||||. |||
WEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ERK5_a-2.AA CMGC 16-324 26 2.9e-125 413.92 In-house 1-513 (513) Show / Hide 
Range on Protein: 16-324
Range on HMM: 1-513/513
Sequence Identity: 26% (140 aa)

YKILEVIGKGSYGVVCSATDMHTGDK--------------VAIKKINDIFEHVSDAT----------RILREIKLLRLLR----------------HPD-
|.|...||.|.||||....| .|. |              ||||||   | .  .|           |.|||||.|. |.                |.  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVEIKHIMLPP-SRRE-----------FKDIYVVFELMESDLHQVIKAND---------DLTPEH------------YQFFL------YQLLRALK--YI
|| .. |  .. |...           |...| |||.|. ||.|.|| |           |.. |             ..|.      ||.||.||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HTAN--VFHRDLKPKNILANADCKL--------------------KICDFGLARVAFND-----------APTAIFWTVSASNKGWTYLTLL--------
| ..  ..|||||| ||| | .|.|                    |||||||||   .            .                    .        
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSF--------------------KNVNKDDKP

--FFKDYVATRWYRAPE-LCGS-------FFSKYTPAIDIWSIGCIFAEILTG--------KPLFPGKNV-----------VHQLDLMTDMLGTPS----
  .. .||.|||||||| |.|.       .. .||..||.||.||||||..||        ||||||..            ..||... ..||||.    
NRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQ

-----------AESVARVRN---------------------EKARRYLSG---MRKKTAIPFTQKFPN--------------------------------
            |    . .                     |.||.|..      ..  .|....||.                                
KGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFK

---ADPLALRLLERLLAFDPKDRPTAEEALADPYF
   .||.|. ||...| .||..|.|||.||. |||
RKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase ERK5_a-2.AA ERK5 16-324 46 3.3e-116 392.35 In-house 1-295 (295) Show / Hide 
Range on Protein: 16-324
Range on HMM: 1-295/295
Sequence Identity: 46% (144 aa)

YKILEVIGKGSYGVVCSATDMHTGDKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDIVEIKHIMLPPS-RREFKDIYVVFELMESDLHQVIKANDDL
|||.| || | |||||||    .|..||||||   |. |  | | .||.|.||  ||  |. |. |. |     |.||.||||.||||||||.| .|  .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TPEHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVAFNDAPTAIFWTVSASNKGWTYLTLLFFKDYVATRWYRAPELCGSFFS
| ||  .||||.|| |||.| |.| |||||| |.| |  | ||| |||.||            | |. ..       .|  .||||||||||||  |   
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARG---------LCTFSPDKH------QMFMTEYVATRWYRAPELMFS-SH

KYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSAESVARVRNEKARRYLSG-MRKKTAIPFTQKFPNADPLALRLLERLLAFDPKDRP
 || |||.||.|||| |... . .||||| .|||.|. ..||.|..  .  |  .. . |.   .  ..  .. . .| ||. || || |.| |.| .| 
DYTQAIDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERI

TAEEALADPYF
|. .||  |. 
TVNKALQHPFL
Kinase ERK5_a-2.AA S_TKc 16-324 28 1.4e-95 324.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-324
Range on HMM: 1-231/231
Sequence Identity: 28% (94 aa)

YKILEVIGKGSYGVVCSATDMHTGDKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDIVEIKHIMLPPSRREFKDIYVVFELMES---DLHQVIKAND
|.||..||||..|.|. ... .|| .||||.|.          .|.|||..|.  .|| || .. ..        ...|.|.|...    ||...|| . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

D------LTPEHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVAFNDAPTAIFWTVSASNKGWTYLTLLFFKDYVATRWYRAP
       ... | .|..||...||.|.|  .. |||||| ||| .    .|||||||||.                            . .. |.||.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------TTFCGTPWYMAP

ELCGSFFSKYTP-AIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSAESVARVRNEKARRYLSGMRKKTAIPFTQKFPNADPLALRLLERLL
|..     .|.. ..|.||.|||..| |.|.|.||      |...| ...|                                     .| |. .....|
EVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCL

AFDPKDRPTAEEALA-------DPYF
 .||..|||| |||.       .|.|
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ERK5_a-2.AA Pkinase 16-324 28 1e-83 289.22 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-324
Range on HMM: 1-293/293
Sequence Identity: 28% (95 aa)

YKILEVIGKGSYGVVCSATDMHTGDKVAIKKINDIFEHVSDATRILR--EIKLLRLLRHPDIVEIKHIMLPPSRREFKDIYVVFELMES-----DLHQVI
|.|...||.||.|.|. ...  ||..||.|.|.   |. .   . .|  ||.... |.|| ||......        ..||.|.|..|      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K--ANDDL--TPEHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKL----KICDFGLARVAFNDAPTAIFWTVSASNKGWTYLTLLFFKDYVAT
.  ..  .  .... .|..||.||.|.|.|  .. |||||| ||| . .. .    ||||||||...                    |     ..... |
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------------Y-NNS-MTTFCGT

RWYRAPELCGSFFSKYTPAIDIWSIGCIFAEILTGKPLFPGK----NVVHQLDLMTDMLGTPSAESVARVRNEKARRYLSGMRKKTAIPFTQKFPNADPL
.||.|||..  . ..|.|..|.||.|||..| |.|.|.|||.    | . |. ..   .|.|  ..    ...  .  ..  . .  . .. . .|... 
PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEE

ALRLLERLLAFDPKDRPTAEEALADPYF
.. .....|..|||.|||||..| .|.|
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ERK5_a-2.AA MAPK-Unclassified 16-195 44 5e-72 245.6 In-house 1-188 (575) Show / Hide 
Range on Protein: 16-195
Range on HMM: 1-188/575
Sequence Identity: 44% (84 aa)

YKILEVIGKGSYGVVCSATDMHT-GDKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDIVEIKHIMLPPSRRE--FKDIYVVFELMES---DLHQVIK
|   ..|| |.||.|| |.|  . . .|||||.| ||. ..|. |.|||| .|| | || |. |. |  . .     |.|||.| ..|..   ||||.||
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

AND-DLTPEHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLAR-VAFNDAPTAIFWTVSASNKGWTYLTLLFFK
 |   .  .| | |.||.|| |||.| |.. |||||| |.|.| || ..|||||..| .  |      |.| |       |||||  |
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIEDNQNLRFSFFTFSLLIGFIIYLTLLRMK
Kinase ERK5_a-2.AA p38 16-165 45 6.3e-61 206.91 In-house 1-154 (289) Show / Hide 
Range on Protein: 16-165
Range on HMM: 1-154/289
Sequence Identity: 45% (70 aa)

YKILEVIGKGSYGVVCSATDMHTGDK---VAIKKINDIFEHVSDATRILREIKLLRLLRHPDIVEIKHIMLP--PSRREFKDIYVVFELMESDLHQVIKA
|. |. .|.|.|| ||.| |  ||.|   |||||..  |. . .| |. ||..||...||  ....  .  |   |...|.|.|.| ..|..||....| 
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

NDDLTPEHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLAR
   |. .| || .||.||.||||| |.. |||||| ||  | || |.| ||||||
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR
Kinase ERK5_a-2.AA nmo 17-166 47 4.1e-58 177.01 In-house 2-151 (292) Show / Hide 
Range on Protein: 17-166
Range on HMM: 2-151/292
Sequence Identity: 47% (71 aa)

KILEVIGKGSYGVVCSATDMHTGDKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDIVEIKHIMLPPSRREFKDIYVVFELMESDLHQVIKANDDLTP
.    || | .||| | ||   | .||.||. ..|  .  . |. ||.|.|   .|  ..  . |. ||    |..|||| ||| ||||..| .   |..
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

EHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLARV
.| . ||||.|| |||.|.||. |||.|| |.| |..| |||||||||||
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARV
Kinase ERK5_a-2.AA ERK1 16-167 51 1.7e-57 197.32 In-house 1-150 (289) Show / Hide 
Range on Protein: 16-167
Range on HMM: 1-150/289
Sequence Identity: 51% (78 aa)

YKILEVIGKGSYGVVCSATDMHTGDKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDIVEIKHIMLPPSRREFKDIYVVFELMESDLHQVIKANDDLT
|  |. ||.| ||.|||| |  ....||||||   |||     | |||||.|   .|  |..|. |.  ..  ...|.|.| .||| || ...|.   | 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

PEHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVA
 .|  .||||.|| ||||| ||| |||||| |.| |  | ||||||||||.|
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIA
Kinase ERK5_a-2.AA ERK7 16-165 48 2.5e-56 191.06 In-house 1-148 (292) Show / Hide 
Range on Protein: 16-165
Range on HMM: 1-148/292
Sequence Identity: 48% (73 aa)

YKILEVIGKGSYGVVCSATDMHTGDKVAIKKINDIFEHVSDATRILREIKLLRLLR-HPDIVEIKHIMLPPSRREFKDIYVVFELMESDLHQVIKANDDL
|.|.. .||| ||.|  |.|  |.. ||.||| | |    || |  ||| .|. .. || |. .  ..        .|||.||| ||.||| ||.  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI---RADNDRDIYLVFEFMETDLHAVIRKGNIL

TPEHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLAR
   | |. .||||||.||.| .|| |||||| ||| ...| .|.|||||||
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLAR
Kinase ERK5_a-2.AA p38 196-324 44 1.3e-52 178.03 In-house 162-289 (289) Show / Hide 
Range on Protein: 196-324
Range on HMM: 162-289/289
Sequence Identity: 44% (58 aa)

DYVATRWYRAPELCGSFFSKYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSAESVARVRNEKARRYLSGMRKKTAIPFTQKFPNADP
.|||||||||||   .    || ..||||.||| ||..||..||||.. ..||  .. ..|||..| .... .|.|| |. .. . .   |.. |..|.|
GYVATRWYRAPEIMLNWMH-YTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANP

LALRLLERLLAFDPKDRPTAEEALADPYF
.|. |||..|  ||  | |||||.. |||
QAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase ERK5_a-2.AA ERK1 193-324 50 9.5e-49 168.27 In-house 159-289 (289) Show / Hide 
Range on Protein: 193-324
Range on HMM: 159-289/289
Sequence Identity: 50% (67 aa)

FFKDYVATRWYRAPELCGSFFSK-YTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSAESVARVRNEKARRYLSGMRKKTAIPFTQKFP
|  .|||||||||||.     || || .|||||.||| ||.|  .|.||||  . || ..  .|| || . .  . ||||| || ..  |. .|. . ||
FLTEYVATRWYRAPEIM--LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFP

NADPLALRLLERLLAFDPKDRPTAEEALADPYF
.||. || ||...|.| |. | | ||||| || 
KADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase ERK5_a-2.AA CDK 16-165 37 4.8e-48 151.7 In-house 1-161 (284) Show / Hide 
Range on Protein: 16-165
Range on HMM: 1-161/284
Sequence Identity: 37% (64 aa)

YKILEVIGKGSYGVVCSATDMHTG-----DKVAIKKINDIF---EHVSDATRI--LREIKLLRLLRHPDIVEIKHIMLPP-----SRREF--KDIYVVFE
|..|| || |.||||  | |..||     . ||.|||       |   .   |  .|||.||. | || || .. . .         . .  . .| |||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

LMESDLHQVIKANDDLTPEHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCK-----LKICDFGLAR
 |. || ....          . ...||||.| |.|  .. |||||| ||| | . .     ||| ||||||
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLAR
Kinase ERK5_a-2.AA MAPK-Unclassified 197-324 31 4.2e-43 149.51 In-house 408-575 (575) Show / Hide 
Range on Protein: 197-324
Range on HMM: 408-575/575
Sequence Identity: 31% (53 aa)

YVATRWYRAPELCGSFFSKYTPAIDIWSIGCIFAEILTG-----------KPLFPGKN--------------------VVHQLDLMTDMLGTPSAESVAR
||.||||||||.  |  . |. ..||||||||||| .             .|||||..                    .. |. .  |.||.|  |   .
YVVTRWYRAPEIMLS-MHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNF

VRNEKARRYLSGMRKKTAIPFTQKFPNADP----------LALRLLERLLAFDPKDRPTAEEALADPYF
... .|| |...  .|| ..||. .. . |          ... ..  .|.|.|. | ||..||  |||
ITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase ERK5_a-2.AA ERK7 196-324 43 4.3e-43 145.04 In-house 165-292 (292) Show / Hide 
Range on Protein: 196-324
Range on HMM: 165-292/292
Sequence Identity: 43% (56 aa)

DYVATRWYRAPE-LCGSFFSKYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSAESVARVRNEKARRYLSGMRKKTAIPFTQKFPNAD
.||||||||||| | ||   .||...| |||||| .|.|.|||.|||   ..|...  .... |..| .. .  . |   |. | ..   .. | .|.. 
EYVATRWYRAPEILLGS--HRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCC

PLALRLLERLLAFDPKDRPTAEEALADPYF
. |. || |||.| || | |||.||. || 
DDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase ERK5_a-2.AA CDK 198-324 35 5.5e-41 128.77 In-house 180-284 (284) Show / Hide 
Range on Protein: 198-324
Range on HMM: 180-284/284
Sequence Identity: 35% (47 aa)

VATRWYRAPELCGSFF--SKYT--PAIDIWSIGCIFAEILT---GKPLFPGKNVVHQLDLMTDMLGTPSAESVARVRNEKARRYLSGMRKKTAIPFTQKF
| |.|||||||    .  ..|.  ..||.||.||||||..|   .||||||..  .||..  ...|||. ..   |                        
VVTLWYRAPEL---LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------

PNADPLALRLLERLLAFDPKDRPTAEEALADPYF
         ||...|..||| | .||.|| .|||
--------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase ERK5_a-2.AA nmo 198-324 39 6.8e-33 98.02 In-house 164-292 (292) Show / Hide 
Range on Protein: 198-324
Range on HMM: 164-292/292
Sequence Identity: 39% (52 aa)

VATRWYRAPE-LCGSFFSKYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSAESVARVRNEKARRYLSGMRKKTAIPFTQKFPN---A
| | .||||| | |.   .|| |.||||.||||||.|  . ||  .. ..||...||.||||| | .    .      | .  |. ...   .      |
VVTQYYRAPEILMGA--RHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHA

DPLALRLLERLLAFDPKDRPTAEEALADPYF
   |  || |.| |||  |  ...||| || 
THEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase ERK5_a-2.AA Pkinase_Tyr 16-170 27 1.9e-16 56.34 Pfam 1-164 (270) Show / Hide 
Range on Protein: 16-170
Range on HMM: 1-164/270
Sequence Identity: 27% (46 aa)

YKILEVIGKGSYGVVCSATDM----HTGDKVAIKKINDIFEHVSDA---TRILREIKLLRLL-RHPDIVEIKHIMLPPSRREFKDIYVVFELMES-DLHQ
 ......|.|..|.|. .|       |. .||.|....   . ...      .||.|... | .|| ||    . .. ..     ||.|.|.|.  ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLD

VIKA----NDDLTPEHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVAFND
  ..    .. ||...   . .|  ... | .  |  ||||  .|.| . . . |||||||||  .||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYND
Kinase ERK5_a-2.AA TyrKc 16-322 20 2.5e-15 25.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-322
Range on HMM: 1-280/280
Sequence Identity: 20% (69 aa)

YKILEVIGKGSYGVVCSATDMHTGDKVAIKKINDIFEHVSDATRILREIKLLRLL--RHPDIVEIKHIMLPPSRREF---KDIYVVFELMES-DLHQVIK
 . ....| | .|.|. .|      .||.|....          ..||..... |  .|| || .  . . ..|. |   . ...|.|.|.  ||.. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

ANDD-LTPEHYQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVAFND---APTAIFWTVSASNKGWTYLTLLF--FKDY-VATRW
.. . |....   | .|  .   |.|  |. ||||   |.| ...   ||.||||.|   .|                    | .      ... .  ||
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG------------ESKDYYRKKEHKGGKTMLPIRW

YRAPELCGSFFSKYTPAIDIWSIGCIFAEILT-GKPLFPG-----KNVVHQLDLMTDMLGTPSAES----VARVRNEKARRYLSGMRKKTAIPFTQKFPN
. |||    ...|.|.. |.|| |    ||.| |..  ||     ..  . . .  .    |  ..                               |. 
M-APECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------FVC

ADPLALRLLERLLAFDPKDRPTAEEALADP
. .   .. ..  ..||.|||| .|   . 
CPDEMYQIMKQCWHEDPEDRPTFSEIHECF