Gene MAK_c (S.moellendorffii)

MAK_c

Species: S.moellendorffii
Alias: MAK_c
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
MAK_c.AA Protein None 360 None Fasta, JSON
MAK_c.NA RNA None 1083 None Fasta, JSON
MAK_c.kin_dom Protein Kinase Domain None 296 None Fasta, JSON

Protein domain

Protein domains of MAK_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAK_c.AA MAK 121-324 53 2.5e-140 449.64 In-house 111-352 (352) Show / Hide 
Range on Protein: 121-324
Range on HMM: 111-352/352
Sequence Identity: 53% (129 aa)

YLQECNLYQMMKDRQK-LFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTV------------------DVIKIADFGLAREVRSRPPYTNYVS
|..| |||||||||.. .|||  |||  .|.|||||.||. |.||||.||||....                   ..|||||||||||.||.|||| |||
YMKE-NLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRSKPPYTDYVS

TRWYRAPEVLLQSSLYNSAVDMWAMGAIMAELFNLRPIFPGASEADEIYKICSVLGNPSQAT----------------WPDGMKLAKCMNFRFPQFVP--
||||||||||| |. |.| .||||.|.|||||. .||.|||.|| |.|.|||.||| |  ..                |||| .||  ||||||| ||  
TRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNFRFPQCVPPS

-ANLSALVPSASA-EAIDLMKAMFAWDPLKRPTPSQALQHPFF
  .|. |.|..|  .||.||| | .||| ||||..|....|.|
IMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase MAK_c.AA RCK 126-324 57 1.8e-139 445.34 In-house 85-298 (298) Show / Hide 
Range on Protein: 126-324
Range on HMM: 85-298/298
Sequence Identity: 57% (124 aa)

NLYQMMKD---RQKLFPEAK--IRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT----------VDVIKIADFGLAREVRSRPPYTNYVSTRWYRAPEV
||||||||   |.|..|| .  |.|  .|.|||||.||. |.|||||||||...|           |.||||||||.||.||.|||| |||||||||||.
NLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPEC

LLQSSLYNSAVDMWAMGAIMAELFNLRPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCMNFRFPQFVPANLSALVPSASAEAIDLMKAMFAWDPL
|| .  ||| .|.||.|.||.||  ||| |||.|| |.|.|||.|.| |.. .|||| |||  |||.||| .. .|. |.|..| ..|.||. | .||| 
LLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQ

KRPTPSQALQHPFF
||.|..||||||.|
KRITAQQALQHPYF
Pkinase MAK_c.AA Pkinase 29-324 31 3.4e-95 327.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 29-324
Range on HMM: 1-293/293
Sequence Identity: 31% (100 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMNLR---EVKSLRKLNHPNIVKLKEVIRENNELFFVFEYM--VLYFCFPFS----ATH
|......| |..|.|.|...| |...||.|..|..  ........|   |.. ...|||||||.|... ...... .|.||.   || ..  .    .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYIST--

VYLQECNLYQMMKDRQKLF--PEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT-VDVI----KIADFGLARE--VRSRPPYTNYVSTRWYRAPEV
             .|.. |  .|  ..... |.|.||.|.|..|  ||||||||.|.   ..|    ||.|||||.     . . .| .. |.||.||||
-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV

LLQSSLYNSAVDMWAMGAIMAELFNLRPIFPGA----SEADEIYKICSVLGNPSQATWPDGMKLAKCMNFRFPQFVPANLSALVPSASAEAIDLMKAMFA
.. .. | ..||||..| |..|... ||.|||.    . .|....|| ..| |    ||        . ||. .     .. . . .| |..|..| ...
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLC

WDPLKRPTPSQALQHPFF
.|| ||||. |.||||.|
KDPKKRPTAEQILQHPWF
S_TKc MAK_c.AA S_TKc 29-324 30 3.4e-94 320.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-324
Range on HMM: 1-231/231
Sequence Identity: 30% (94 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMNLREVKSLRKLNHPNIVKLKEVIRENNELFFVFEYMVLYFCFPFSATHVYLQEC---
|......| |..|.|.|...| |.. ||||..|        .. .||.. |.| .|||||||..|... ..|..|.||.                .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYC----------------DGDLG

NLYQMMKDRQKL-----FPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVDVIKIADFGLAREVRSRPPYTNYVSTRWYRAPEVLLQSSLYNS-
.|....|.|..      |||  .| .. |....|.|.|. |  ||||||||.|..  .|||.||||||..      | .. |.||.|||||     |.  
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKC

AVDMWAMGAIMAELFNLRPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCMNFRFPQFVPANLSALVPSASAEAIDLMKAMFAWDPLKRPTPSQAL
..|.|. | |..|..  .| ||   . ....|..                                        | ||.|... .. .|| ||||  .||
KCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

Q-------HPFF
|       ||.|
QDEWDIKCHPWF
Kinase MAK_c.AA CMGC 124-324 25 8.6e-90 295.16 In-house 138-513 (513) Show / Hide 
Range on Protein: 124-324
Range on HMM: 138-513/513
Sequence Identity: 25% (97 aa)

ECNLYQMMKDRQ---------------------------KLFPEAKIRNWCFQVLQGLA--YMHREG--YFHRDLKPENLLVTVD---------------
...|||..|. |                           | |.   || ...|.|.||.  |.|. .   .||||||||.|.. .               
DHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWN

------VIKIADFGLAR--EVRSRP--------------------PYTNYVSTRWYRAPEVLLQSSLYN---------SAVDMWAMGAIMAELFN-----
      ..||.||||||  ...|..                    |||.||.||||||||.|| .. |.         ...|||. | |.||...     
PCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSL

---LRPIFPGASE-----------ADEIYKICSVLGNPS---------------QATWPDGMK-------------------------LAKCMNFRFPQF
   ..|.||| ||            | ..||. |||.|.               . .||.  |                         ... .|.|||..
IFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWW

VPANLSALVPS-----------------------------------ASAEAIDLMKAMFAWDPLKRPTPSQALQHPFF
 | ... |.|                                    .. .||||.| |. .|| ||.|..||||||.|
PPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase MAK_c.AA MOK 29-324 37 7.2e-87 272.24 In-house 1-283 (283) Show / Hide 
Range on Protein: 29-324
Range on HMM: 1-283/283
Sequence Identity: 37% (113 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMNLREVKSLRKLN-HPNIVKLKEVI--RENNELFFVFEYMVLYFCFPFSATHVYLQEC
|| | ..|.||.  | |       .  | |.||... | ..  ||||.. .|.|| ||||..|.||.  |   .|  . | |                . 
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELM----------------DM

NLYQMMKDRQKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVDVIKIADFGLAREVRSRPPYTNYVSTRWYRAPEVLLQSSLYNSAVDMWA
|.| ... |    |. ||... .|... |  ||| | |||| ||||.|.  |..|.||||  | | |. ||| |.||||||||| ||    |   .|||.
NIYELIRGRRHYLPQKKIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWS

MGAIMAELFNLRPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCMNFRFPQFVPANLSALVPSASAEAIDLMKAMFAWDPLKRPTPSQALQHPFF
 | .  |.  |.|.|||. | | | ||  |.| | | .     . .. ||. ||    . .  |.| ..  ....|..| ..||  | |  |..|||.|
VGCVFYEIASLHPLFPGVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase MAK_c.AA CDK7 132-324 41 3.6e-77 204.94 In-house 93-288 (288) Show / Hide 
Range on Protein: 132-324
Range on HMM: 93-288/288
Sequence Identity: 41% (81 aa)

KDRQKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVD-VIKIADFGLAREVRS-RPPYTNYVSTRWYRAPEVLLQSSLYNSAVDMWAMGAI
|| . ..  | | ..  ..|||| |.||    |||||| |||.  . ..|||||||||   |    ||  | |||||||| |     | ..||||..| |
KDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCI

MAELFNLRPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCMNFR-FPQFVPANLSALVPSASAEAIDLMKAMFAWDPLKRPTPSQALQHPFF
.|||    |..|| |. | . .|.. || |. ..||.  ...  . |. || .    |  .   || ...|||. |.. .|.|| | .|.|..|.|
FAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase MAK_c.AA CDK 124-324 35 4.8e-74 236.24 In-house 101-284 (284) Show / Hide 
Range on Protein: 124-324
Range on HMM: 101-284/284
Sequence Identity: 35% (77 aa)

ECNLYQMMKDRQKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVD-V-----IKIADFGLAREVRS-------RPPYTNYVSTRWYRAPEV
.  |.. |.          |... .| |.||.|.|. .  |||||| |.|.. . .     .|||||||||.  .       . .||. | |.||||||.
DHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPEL

LLQSSLYN--SAVDMWAMGAIMAELFN---LRPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCMNFRFPQFVPANLSALVPSASAEAIDLMKAMF
|| |. |.   ..|||. | |.||.|.    .|.||| || | . ||. ..| |.  .||.  ||                            ||.  |.
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKML

AWDPLKRPTPSQALQHPFF
. || || . .||||||.|
CYDPKKRISAEQALQHPYF
Kinase MAK_c.AA CDC2 123-324 38 4.9e-68 208.02 In-house 82-301 (301) Show / Hide 
Range on Protein: 123-324
Range on HMM: 82-301/301
Sequence Identity: 38% (84 aa)

QECNLYQMMK---DRQKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVD-VIKIADFGLAREVRS-RPPYT--NYVSTRWYRAPEVLLQSS
....| . |.     .| .|......  .| |||... |. . .|||||| |.|.  . .|||||||||| .     .||    | |.||||||.|| ..
LDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCK

LYNSAVDMWAMGAIMAEL---FNLRPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCMNFRFPQFVPANLSALVPS---------ASAEAIDLMKA
 |. .||||. | |.||.    . .|.|.| || |...||  .|| |.  ||| |..  .  .  ||.. | .|| ..|.         .  |.||| . 
RYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWP-GVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQ

MFAWDPLKRPTPSQALQHPFF
| . || || .  .|||||.|
MLQYDPQKRISAKEALQHPYF
Kinase MAK_c.AA RCK 29-107 74 1.5e-59 187.53 In-house 1-82 (298) Show / Hide 
Range on Protein: 29-107
Range on HMM: 1-82/298
Sequence Identity: 74% (61 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMNLREVKSLRKLN-HPNIVKLKEVIRENN--ELFFVFEYM
|..||||||||||.| ||.|| |.| |||||||.|. ||.|||||||.||||||| ||||.|||||||.|.  .|.||||||
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYM
Kinase MAK_c.AA CDK5 143-324 36 4.9e-55 172.11 In-house 100-287 (287) Show / Hide 
Range on Protein: 143-324
Range on HMM: 100-287/287
Sequence Identity: 36% (70 aa)

IRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVD-VIKIADFGLARE----VRSRPPYTNYVSTRWYRAPEVLLQSSLYNSAVDMWAMGAIMAELF-NL
|.   .| |.|||. | .   |||||| |||.      | |||||||     ||    |.  | | |||.| ||. | .|.  .||| .| |.||.  ..
IKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC---YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAG

RPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCM--NFRFPQFVPAN-LSALVPSASAEAIDLMKAMFAWDPLKRPTPSQALQHPFF
|| |||... |.  .|  ..| |.  .||   || .       .| . .   .. .||. ...  ||.. |   .| .| .  .||.||.|
RPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase MAK_c.AA MAPK 122-324 35 9.3e-55 187.75 In-house 97-328 (328) Show / Hide 
Range on Protein: 122-324
Range on HMM: 97-328/328
Sequence Identity: 35% (82 aa)

LQECNLYQMMKDRQKLFPEAKIRNWCFQVLQG--LAYMHREGYFHRDLKPENLLVTVD-VIKIADFGLAREVRSRPPY---------------TNYVSTR
| |..|.| .| .|    .  |.   .|.| |  | |.|  .  ||||||.|.||. .   ||.|||||| . .   .               | ||.||
LMETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPEVLLQ--SSLYNSAVDMWAMGAIMAELFN-LRPIFPGASEADEIYKICSVLGNPSQATW--PD-GMKLAKCMNFR--FPQFVPANLSALVPS---
||||||..|   .  |. |||||. | |.||. .  .|.||| .  | . .| .|||.||.  .       . ..    .  .|.  . ... . |    
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

-ASAEAIDLMKAMFAWDPLKRPTPSQALQHPFF
 |. .||||.. | ..|| || |  .|||||.|
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase MAK_c.AA MAK 29-107 52 2.4e-51 161.45 In-house 1-112 (352) Show / Hide 
Range on Protein: 29-107
Range on HMM: 1-112/352
Sequence Identity: 52% (59 aa)

YKVIKQLGDGTYGTVWKAVN------------------------------KVTNETVAIKKMKRKYLSWDECMNLREVKSLRKLN-HPNIVKLKEVIR--
| .||||||||||.| .|                                . | | ||||.||.|. ||.|||||||||||.||| ||||||||||||  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

ENNELFFVFEYM
||..|.||||||
ENDHLYFVFEYM
Kinase MAK_c.AA CDKL 139-258 41 9.7e-47 157.82 In-house 96-218 (286) Show / Hide 
Range on Protein: 139-258
Range on HMM: 96-218/286
Sequence Identity: 41% (52 aa)

PEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT--VDVIKIADFGLAREVRSRPP--YTNYVSTRWYRAPEVLLQSSLYNSAVDMWAMGAIMAELF
.| ..|. ..|.|..... |     ||| ||||.|.|   ...|. |||.||   . |   || || |||||||| |.    | ..||.|| | .|||..
DEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMI

NLRPIFPGASEADEIYKICSVLGN
   |..|| |. |  |.|  .||.
DGQPLWPGQSDIDQLYHIQKCLGP
Kinase MAK_c.AA CMGC 29-107 28 1.2e-35 113.96 In-house 1-137 (513) Show / Hide 
Range on Protein: 29-107
Range on HMM: 1-137/513
Sequence Identity: 28% (39 aa)

YKVIKQLGDGTYGTVWKAVN--------------KVTNETVAIKKMK-RKYLSWDEC----------MNLREVKSLRKLN-----------------HPN
|..||..| ||||.|.|...              . ||| |||||.| ..   ....          . |||.| |..||                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLKEVIRENN-----------------ELFFVFEYM
||||..... .|                 .|..|||||
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYM
Kinase MAK_c.AA CDK 29-107 34 2.4e-28 87.67 In-house 1-100 (284) Show / Hide 
Range on Protein: 29-107
Range on HMM: 1-100/284
Sequence Identity: 34% (35 aa)

YKVIKQLGDGTYGTVWKAVNKVTN-----ETVAIKKMK---RKYLSW-DECMN---LREVKSLRKLNHPNIVKLKEVIREN-----------NELFFVFE
|. ....| ||||.| || .| |.     . ||.|| .    . ..  .| ..   .||.. |..| |||||||..|.  .           | |..|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YM
||
YM
Kinase MAK_c.AA CDC2 29-107 40 1.4e-26 78.25 In-house 1-82 (301) Show / Hide 
Range on Protein: 29-107
Range on HMM: 1-82/301
Sequence Identity: 40% (34 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDE---CMNLREVKSLRKLN-HPNIVKLKEVIRENNELFFVFEYM
|. |. .| |||| | |. .. ||. ||.|| . .. . ..      .||   | .|. |||||||..|| . | |. ||||.
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYL
Kinase MAK_c.AA CDK7 29-107 32 3.8e-25 63.53 In-house 1-84 (288) Show / Hide 
Range on Protein: 29-107
Range on HMM: 1-84/288
Sequence Identity: 32% (28 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMN------LREVKSLRKLNHPNIVKLKEVIRENNELFFVFEYM
|. ||..| |...|| ||  ..|.. ||||| | | .. .|         .||.| |. . |.|.. |  ..     .  ||..|
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIK-KLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFM
Kinase MAK_c.AA CDK5 29-107 42 5.9e-23 68.94 In-house 1-80 (287) Show / Hide 
Range on Protein: 29-107
Range on HMM: 1-80/287
Sequence Identity: 42% (35 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDE---CMNLREVKSLRKLNHPNIVKLKEVIRENNELFFVFEYM
|. .  .|.||||||.|| || | | ||.|. .    | ||   .  .||.  |. | |.||| |  ||  .. |  |||..
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLD--SEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFC
Kinase MAK_c.AA MAPK 29-107 30 6.1e-21 68.98 In-house 1-98 (328) Show / Hide 
Range on Protein: 29-107
Range on HMM: 1-98/328
Sequence Identity: 30% (30 aa)

YKVIKQLGDGTYGTVWKAVNKV------TNETVAIKKMKRKYLSWDECMN-LREVKSLRKL-NHPNIVKLKEVIREN-----------NELFFVFEYM
|. .|..| | ||.|..|. |       ....|||||. |   .   |   .||.| || . .|.||.||.....             |.. .|.|.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM
Kinase MAK_c.AA CDKL 29-107 42 7.7e-19 61.04 In-house 1-80 (286) Show / Hide 
Range on Protein: 29-107
Range on HMM: 1-80/286
Sequence Identity: 42% (34 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKR-KYLSWDECMNLREVKSLRKLNHPNIVKLKEVIRENNELFFVFEYM
|  .  .| | ||.| |  || |.. ||||| |  ..        .||.| |. | |.||| |.|| | ...|. ||||.
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYC
Kinase MAK_c.AA TyrKc 29-324 23 2.3e-17 57.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 29-324
Range on HMM: 1-280/280
Sequence Identity: 23% (78 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMNLREVKSLRKL--NHPNIVKLKEVIREN-------NELFFVFEYMVLYFCFPFSATH
 . .|.|| | .|.|.|.. |   ..||.|..|       . . .|| . ..||  .|||||.|  |...          |. |.|||      |  . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM------PHGDLK

VYLQECNLYQMMKDRQKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVDV-IKIADFGLAREVRSR-------PPY-------TNY-VSTR
 ||...            .. ..  ..|.|. .| .| |. .. ||||   | ||. .  .||.||||.|.. .          |       ... .  |
DYLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

WYRAPEVLLQSSLYNSAVDMWAMGAIMAELFNL----RPI----FPGASEADEIYKICSVLGNPSQ----ATWPDGMKLAKCMNFRFPQFVPANLSALVP
|. |||.. . . .... | |. |  | |.| .     |     .  ..|. |  |    .  |      .                        .   .
WM-APECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------F---V

SASAEAIDLMKAMFAWDPLKRPTPSQALQHPFF
 ...|  ..||   . || .||| |.   | .|
CCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MAK_c.AA Pkinase_Tyr 29-107 31 2.3e-12 42.53 Pfam 1-89 (270) Show / Hide 
Range on Protein: 29-107
Range on HMM: 1-89/270
Sequence Identity: 31% (28 aa)

YKVIKQLGDGTYGTVWKAVNK----VTNETVAIKKMKRKYLSWD--ECMNLREVKSLRKL-NHPNIVKLKEVIR-ENNE--LFFVFEYM
 . .|.|| | .|.|.|.. |     |. .||.|..| .. . .    . .||.| ...| .|||||.|  |.  .     .. |.|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYM
Kinase MAK_c.AA CDKL 290-324 38 4.9e-11 33.98 In-house 251-286 (286) Show / Hide 
Range on Protein: 290-324
Range on HMM: 251-286/286
Sequence Identity: 38% (14 aa)

VPSAS-AEAIDLMKAMFAWDPLKRPTPSQALQHPFF
.| .| ..|.|.||...  || .|.| .|...||.|
YPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase MAK_c.AA Pkinase_Tyr 126-236 27 1.1e-07 26.7 Pfam 93-210 (270) Show / Hide 
Range on Protein: 126-236
Range on HMM: 93-210/270
Sequence Identity: 27% (33 aa)

NLYQMMKDR---QKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT-VDVIKIADFGLAREVRSRPPYTNYVST------RWYRAPEVLLQSS
.|.   ...   .. ..   . ..|.|. .|..| .. .. ||||   | |||   |.||.|||||| . .   |  ....      .|. |||..  . 
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK

LYNSAVDMWAMGAIMAELFNL
 .... | |. |  | |.| .
-FTTKSDVWSFGVLMWEIFTY