Gene MOK (S.moellendorffii)

MOK

Species: S.moellendorffii
Alias: MOK
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MOK

Sequence

Name Sequence Type Origin Length Description Download
MOK.AA Protein None 292 None Fasta, JSON
MOK.NA RNA None 879 None Fasta, JSON
MOK.kin_dom Protein Kinase Domain None 220 None Fasta, JSON

Protein domain

Protein domains of MOK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MOK.AA RCK 64-288 49 9.80000000001e-157 501.06 In-house 1-240 (298) Show / Hide 
Range on Protein: 64-288
Range on HMM: 1-240/298
Sequence Identity: 49% (118 aa)

YRMICKKGEGTFSEVLKAQCHKSNKYVAIKCMKNTFDSLEQVTNLREIQALQRLSPHTNVIKLLEVLYDQPTGRLALVFELMDMNIYELIRG---RRTYV
| .| ..|.||...|.|||  .....||||.||..| |.|...|||||..| .|.|| |.|||.||..|..|..|..|||.||||.|.....   ||.|.
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

SEDR--IKSYMFQLLKAMDHMHRNGIFHRDIKPENILIME----------ESLKLADLGSCRGVYSKQPYTEYISTRWYRAPECLLTDGYYNYKMDMWGV
.|    ||..|.|.|....|||..|.||||.|||||....          . .|.|| |.|| ..||.|||.|.||||||||||||...|||..||.|.|
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GCVFFEIISLFPLFPGTNELDQIQKIHKVMGTPPQQLLDK
||...|. .|.|||||..|.|||.||.|||||| .. ...
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPD
Kinase MOK.AA MOK 64-290 69 1e-153 485.54 In-house 1-227 (283) Show / Hide 
Range on Protein: 64-290
Range on HMM: 1-227/283
Sequence Identity: 69% (157 aa)

YRMICKKGEGTFSEVLKAQCHKSNKYVAIKCMKNTFDSLEQVTNLREIQALQRLSPHTNVIKLLEVLYDQPTGRLALVFELMDMNIYELIRGRRTYVSED
|. | | ||||||||.| |  .   | | | ||  |.|.||| |||||||..||.|| |...| ||..|  || |||. ||||||||||||||| |....
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

RIKSYMFQLLKAMDHMHRNGIFHRDIKPENILIMEESLKLADLGSCRGVYSKQPYTEYISTRWYRAPECLLTDGYYNYKMDMWGVGCVFFEIISLFPLFP
.|. ||.||.|..||||||||||||.||||||| .. ||||| |||| |||||||||||||||||||||||||||| |.|||| |||||.||.|| ||||
KIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLFP

GTNELDQIQKIHKVMGTPPQQLLDKMR
| ||.||| ||| ||||| |..| | .
GVNEVDQISKIHDVMGTPCQKILNKFK
Kinase MOK.AA CMGC 64-288 27 6.30000000001e-103 339.13 In-house 1-379 (513) Show / Hide 
Range on Protein: 64-288
Range on HMM: 1-379/513
Sequence Identity: 27% (103 aa)

YRMICKKGEGTFSEVLKAQC--------------HKSNKYVAIKCMKNTFDSLEQV----------TNLREIQALQRLS---------------PHTN-V
|  | | ||||...| |...              |..|..|||| .|| |.  ..           . ||||. |..|.               .| | .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IKLLEVLYDQPTG---------------RLALVFELMDMNIYELIRG--------RRTYVSEDR------------IKSYM------FQLLKAMD--HMH
.||....|.  .                 | ||||.||.. |..|.         |. . ||              ||..|      .|.|....  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

RNG--IFHRDIKPENILIMEE---------------------SLKLADLGSCR--GVYSKQ--------------------PYTEYISTRWYRAPECLLT
...  |.|||.||||||| ..                      ||..| |..|  ...|..                    |||.|..|||||||| || 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

DGYYN---------YKMDMWGVGCVFFEIIS--------LFPLFPGTNE-----------LDQIQKIHKVMGTPPQQLLDK
...|.         ...|||.|||.|.|..         . ||||| .|           .||..|| ||.|||. ....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQK
Kinase MOK.AA MAK 64-281 38 8.6e-96 305.42 In-house 1-267 (352) Show / Hide 
Range on Protein: 64-281
Range on HMM: 1-267/352
Sequence Identity: 38% (103 aa)

YRMICKKGEGTFSEVLKAQC------------------------------HKSNKYVAIKCMKNTFDSLEQVTNLREIQALQRLSPHTNVIKLLEVLYDQ
| || . | ||. .|..|.                                ..   |||| ||  | |.|  .||||. .|  |. | |..||.||. | 
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

PTGRLALVFELMDMNIYELIRGRRT-YVSEDRIKSYMFQLLKAMDHMHRNGIFHRDIKPENILIME------------------ESLKLADLGSCRGVYS
    | .||| |  | |... .|.. . .|  |.. |.| | .. .||..| ||||.|||||..|                   | .|.|| |  | . |
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

KQPYTEYISTRWYRAPECLLTDGYYNYKMDMWGVGCVFFEIISLFPLFPGTNELDQIQKIHKVMGTP
| ||| |.||||||||| ||  .||.  .||| |||.  |. .. |||||..| ||| || .|.|||
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTP
Kinase MOK.AA CDK 64-284 33 1e-82 264.41 In-house 1-247 (284) Show / Hide 
Range on Protein: 64-284
Range on HMM: 1-247/284
Sequence Identity: 33% (87 aa)

YRMICKKGEGTFSEVLKAQCHKSN-----KYVAIKCMKNTF------DSLEQVTNLREIQALQRLSPHTNVIKLLEVLYDQPTG---------RLALVFE
| ...| ||||. .| ||......     ..||.|. .         .     | .|||  |. |  | |..||..| ..  .          .| .|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

LMDMNIYELIRGRRTYVSEDRIKSYMFQLLKAMDHMHRNGIFHRDIKPENILIMEES------LKLADLGSCRGVYS-------KQPYTEYISTRWYRAP
 ||.  .....          ||.||.|||......|.|.| |||.|| ||||..        ||.|| |  |   .        ..||  . |.|||||
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

ECLLTDGYYN--YKMDMWGVGCVFFEIIS---LFPLFPGTNELDQIQKIHKVMGTPPQQ
| || .  |.     |||.|||.| |..      |||||..|.||. || ...|||  .
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTED
Kinase MOK.AA CDC2 64-281 35 3e-69 211.82 In-house 1-228 (301) Show / Hide 
Range on Protein: 64-281
Range on HMM: 1-228/301
Sequence Identity: 35% (83 aa)

YRMICKKGEGTFSEVLKAQCHKSNKYVAIKCMKNTFDSLEQ---VTNLREIQALQRLSPHTNVIKLLEVLYDQPTGRLALVFELMDMNIYELIR---GRR
|  | | ||||. .| |..  ..|..||.|  . . .. .     | .|||  |. | .| |..|| .|..     .| .||| .||.  .. .   . .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

TYVSEDRIKSYMFQLLKAMDHMHRNGIFHRDIKPENILIMEE-SLKLADLGSCRGV-YSKQPYT--EYISTRWYRAPECLLTDGYYNYKMDMWGVGCVFF
...... .||||.|.|..... |...|.|||.|| |||| .. ..|.|| |  | . . . .||    . |.|||||| || . .|.   ||| .||.| 
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EI---ISLFPLFPGTNELDQIQKIHKVMGTP
|.   ..  |||.|  | ||. || ...|||
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTP
Kinase MOK.AA Pkinase 64-282 32 1.9e-67 235.16 Pfam 1-235 (293) Show / Hide 
Range on Protein: 64-282
Range on HMM: 1-235/293
Sequence Identity: 32% (78 aa)

YRMICKKGEGTFSEVLKAQCHKSNKYVAIKCMKNTFDSLEQ-VTNLR--EIQALQRLSPHTNVIKLLEVLYDQPTGRLALVFELMDM-----NIYELIR-
|. . | |.|.|..| |.. ....| ||.|..|   .. .. .|..|  ||| ..||  | |...|... .|   ... .|.|....       ...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

GRRTYV--SEDRIKSYMFQLLKAMDHMHRNGIFHRDIKPENILIM-EESL----KLADLGSCRG--VYSKQPYTEYISTRWYRAPECLLTDGYYNYKMDM
 |.. .  ||. .|.|| |.|......|..|| |||.|||||||  .  .    |..| |...     ... .| .  |.||.||| .... || .| ||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WGVGCVFFEIISLFPLFPGT----NELDQIQKIHKVMGTPP
|..||...| ..  |.|||     | .||.|.| ..||.|.
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPL
Kinase MOK.AA CDK7 64-281 38 1.9e-62 164.94 In-house 1-222 (288) Show / Hide 
Range on Protein: 64-281
Range on HMM: 1-222/288
Sequence Identity: 38% (86 aa)

YRMICKKGEGTFSEVLKAQCHKSNKYVAIKCMK------NTFDSLEQVTNLREIQALQRLSPHTNVIKLLEVLYDQPTGRLALVFELMDMNIYELIRGRR
|  | . |||.|  | ||. |.... ||||  |       . | ..  | .|||  || .. | ||| |. ..  .    . |||..||    . |.   
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGIN-RTAIREIKILQEMQ-HDNVIGLIDIFMHKSN--IQLVFDFMDWDLEVVIKDKS

TYVSEDRIKSYMFQLLKAMDHMHRNGIFHRDIKPENILIMEE-SLKLADLGSCRGVYS-KQPYTEYISTRWYRAPECLLTDGYYNYKMDMWGVGCVFFEI
       ||.|| ..|. . ..||| | |||.|| | |. |.  ||.|| |  |   |  . ||  . |||||||| |     |    ||| |||.| | 
IILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAEL

ISLFPLFPGTNELDQIQKIHKVMGTP
.   | .||....||...| . .|||
MLRVPYLPGDSDIDQLTRIFQTLGTP
Kinase MOK.AA S_TKc 64-292 28 3.5e-62 213.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 64-292
Range on HMM: 1-231/231
Sequence Identity: 28% (75 aa)

YRMICKKGEGTFSEVLKAQCHKSNKYVAIKCMKNTFDSLEQVTNLREIQALQRLSPHTNVIKLLEVLYDQPTGRLALVFELMDM---NIYELIRGRRT--
|... | |.|.|..| |.. .|....||||..|         . .|||| |..   | |..||..| .|   ..| .|.|..|    . ...|. |..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

---YVSEDRIKSYMFQLLKAMDHMHRNGIFHRDIKPENILIMEESLKLADLGSCRGVYSKQPYTEYISTRWYRAPECLLTDGYYNY-KMDMWGVGCVFFE
   . .| ....|| |...|....|..|| |||.||||||. |  .|..| |..| .      | .. |.||.||| |     |.. | |.| .||...|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

IISLFPLFPGTNELDQIQKIHKVMGTPPQQL------------------LDK-------MRRY
 ..  |.||      |.|.. |..| .|. .                  . .       .   
MLCGYPPFP------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase MOK.AA CDK-Unclassified 64-281 33 1.5e-56 184.45 In-house 1-258 (324) Show / Hide 
Range on Protein: 64-281
Range on HMM: 1-258/324
Sequence Identity: 33% (86 aa)

YRMICKKGEGTFSEVLKAQCHKSNKYVAIK--CMKNTFD---------SLEQVTNLREIQALQRLSPHTNVIKLLEVLYDQPTGR-----------LALV
|||.|| ||||| .| ||     .| ||||    .| ..          .  .| .|||  ||..  | |.||.... ||                . .|
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCN-HMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMV

FELMDMNIYELIRGRRTYVSEDRIKSYMFQLLKAMDHMHRNGIFHRDIKPENILIMEES------LKLADLGSCRGVY-------------SKQPYTEYI
 | |.   |      |   |   |. .| |.|.    .| |.| ||||||.||.|          ||.|| |. .  .             . | |.  .
MEYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQV

STRWYRAPECLLTDGYYNYKMDMWGVGCVFFEIISLFPLFPGTNELDQIQKIHKVMGTP
||||||||| |. .  |..  |.|..||.. |..   |.|.|..|..|. .| |..|||
STRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTP
Kinase MOK.AA CDKL 64-280 38 2.1e-54 184.42 In-house 1-218 (286) Show / Hide 
Range on Protein: 64-280
Range on HMM: 1-218/286
Sequence Identity: 38% (85 aa)

YRMICKKGEGTFSEVLKAQCHKSNKYVAIKCMKN-TFDSLEQVTNLREIQALQRLSPHTNVIKLLEVLYDQPTGRLALVFELMDMNIYELIRGRRTYVSE
|  . | |||    |.|     ....||||  |    | ..  . .|||  |  |  | |   |.||   .  ..| |||| .| .. ..   . . | |
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLK-HENIVNLIEVF--RRKRKLHLVFEYCDHTVLHELEEYPNGVDE

DRIKSYMFQLLKAMDHMHRNGIFHRDIKPENILIM--EESLKLADLGSCRGVYSKQP--YTEYISTRWYRAPECLLTDGYYNYKMDMWGVGCVFFEIISL
.....||.|.||| .. | . . |||||||||||      .|| | |  |   .|.   ||.|  |||||||| |. |  |    |.| .|||. | |. 
HVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDG

FPLFPGTNELDQIQKIHKVMGT
 ||.|| ...||  .| |..|.
QPLWPGQSDIDQLYHIQKCLGP
Kinase MOK.AA MAPK 64-289 30 5.2e-50 171.06 In-house 1-262 (328) Show / Hide 
Range on Protein: 64-289
Range on HMM: 1-262/328
Sequence Identity: 30% (81 aa)

YRMICKKGEGTFSEVLKAQCHK------SNKYVAIKCMKNTFDSLEQVTN-LREIQALQRLSPHTNVIKLLEVLYD-----QPT----GRLALVFELMDM
|. . . |.| .  | .| . .      ..|.|||| . . |...      .|||  |...  | |.||||....      |..      . .|.|||. 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NIYELIRGRRTYVSEDRIKSYMFQLLKA--MDHMHRNGIFHRDIKPENILIMEE-SLKLADLGSCRGVYSKQPY---------------TEYISTRWYRA
. . .|. ..   |.|.|.. |.|.|..  . ..|  .. |||.||.|||. |.  ||..| |  |.. ... .               |||..||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PECLLTD--GYYNYKMDMWGVGCVFFEIIS-LFPLFPGTNELDQIQKIHKVMGTPPQQLLDKM
|| .|      |. ..||| ||| | | ..   |||||.. .||...| .|.|||..... ..
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCI
Kinase MOK.AA TyrKc 64-289 21 1.5e-11 -36.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 64-289
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

YRMICKKGEGTFSEVLKAQCHKSNKYVAIKCMKNTFDSLEQVTNLREIQALQRL-SPHTNVIKLLEVLYDQ-----PTGRLALVFELMDM-NIYELIRGR
 ... | ||| | || |..       ||.|..|.    .|    .||.. . .|   | |...|. |  .|       . | .|.|.|.  .  . .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDF--MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

RTYVSEDRIKSYMFQLLKAMDHMHRNGIFHRDIKPENILIMEES-LKLADLGSCRGVYSK-------QPYT------EY--ISTRWYRAPECLLTDGYYN
|  .. .   |...|  . |.. |.... |||.   |.|. |.   | .| | .| .|..       . |.      .   .  ||. ||||.  .| ..
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFT

YKMDMWGVGCVFFEIISL-FPLFPG-----TNELDQIQKIHKV--MGTPPQ--------------------------------QLLDKM
 | | |  | . .|| ..  .  ||      .  . |... .   |  ||                                 .. ...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MOK.AA Pkinase_Tyr 64-189 21 2.4e-08 28.86 Pfam 1-137 (270) Show / Hide 
Range on Protein: 64-189
Range on HMM: 1-137/270
Sequence Identity: 21% (30 aa)

YRMICKKGEGTFSEVLKAQCH----KSNKYVAIKCMKNTFDSLE--QVTNLREIQALQRLSPHTNVIKLLEVLY--DQPTGRLALVFELMDM-NIYELIR
 ... | ||| | || |. ..    . .  ||.|..|.. .. .  .   .||.. .  |  | |...|. | .  ..|  .. .|.|.|   . ..  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLR

GR---RTYVSEDRIKSYMFQLLKAMDHMHRNGIFHRDI
 .   .  ..  .. .. .|  |.|.. ..... |||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL