Gene SRPK_d (S.moellendorffii)

SRPK_d

Species: S.moellendorffii
Alias: SRPK_d
External Links:
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
SRPK_d.AA Protein None 589 None Fasta, JSON
SRPK_d.NA RNA None 1770 None Fasta, JSON
SRPK_d.kin_dom Protein Kinase Domain None 441 None Fasta, JSON

Protein domain

Protein domains of SRPK_d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SRPK_d.AA SRPK 356-519 55 7.1e-134 347.03 In-house 391-554 (554) Show / Hide 
Range on Protein: 356-519
Range on HMM: 391-554/554
Sequence Identity: 55% (91 aa)

DLRCKIVDLGNACWTYKQFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGGRFSRE
... ||.|||||||... ||.||||||||||||..| .|.||.||||.||..||||||| ||.||||. . .|.||.|..|||.|. |... | |. |||
KIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSRE

FFNRQGDLRHIKKLRYWPLDKVLHDKYSFPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
|||..|.||||.|| .|||  ||  || .. ..|.. ..|| | |...  || ||..|| ||| 
FFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase SRPK_d.AA SRPK 79-283 45 5.9e-127 328.79 In-house 1-231 (554) Show / Hide 
Range on Protein: 79-283
Range on HMM: 1-231/554
Sequence Identity: 45% (106 aa)

YVVQRKVGWGHFSTVWLAWDTQQKSYVALKVQKSAKHYTEAAFDEISILKQIADGDPS-----------------------NSKCVVKLLDHFKHSGPNG
|.| || ||||||||||.||.| ..|||.|..|||.||||.|.||| .|..... ||.                       | ..||.|||||||.||||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

QHVCMVFEFLGDNLLTIIKLYNYRGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLLTLPLDPSKDPLKSGAPLILSKPAAAAAAATATAGVTS
.|.||||| ||.||| .|| |||.|.|.. |||.. |.|||||||||  .|||||.|||||||..    ..| .|. |  .  .. . .      .. | 
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCV----NQDYIKRMAAEWTEWQKMGMQMPSSSMVQTA

SS-------QPLSKSQKKKLKKKAAKDKTGKDKDM
 .       | .||..|||.|||.....   .|..
PQHQTQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQ
Kinase SRPK_d.AA CMGC 79-519 16 5.6e-102 335.95 In-house 1-513 (513) Show / Hide 
Range on Protein: 79-519
Range on HMM: 1-513/513
Sequence Identity: 16% (110 aa)

YVVQRKVGWGHFSTVWLAWD--------------TQQKSYVALKVQKSAKHYTEAAF-------------DEISILKQIA----------DGDPSNSKC-
| . .|.|.|....|. ..|              .. . .||.|  |... |.| |              .||.|||..           | ||.| .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

-VVKLLDHFKHSGPNGQ-------------HVCMVFEFLGDNLLTIIKLYN--YRG-----LPLPM------------VKQLS------MQILIGLD--Y
 .|||.|.|.|....|.             |...|||... .|. .|| ..  |.|     |.               .| ..       ||| ||.  |
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHRQ-LSIIHTDLKPENVLLTLPLDP-------SKDPLKSGAPLILSKPAAAAAAATATAGVTSSSQPLSKSQKKKLKKKAAKDKTGKDKDMDKAAEAMV
.|.. ..|||.||||||.|..   .        |.                                                                 
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSE-----------------------------------------------------------------

ATVDATAAAVESGKGGSDGAPRHENHKIHADEATGAADAQAPGEAPRLANKHEKRLKVTDLGELDLRC---------KIVDLGNACWTYKQ---------
                                                                             || | |.|.|. .          
-----------------------------------------------------------------D-WNPCQKNGRLKICDFGLARWYHPHSDHHFQQQP

---------------FTNDIQTRQYRSPEVLLGCK----------YSTPVDIWSFACLVFELATG--------DVLFDPHSGD-----QFDKDEDHLALM
               .|....|| ||.||.|||.|          |.||.|.||..|  .|. ||        . || .||..     . ... |.|...
QSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKI

IELLGRMPRKVSLGGR-------FSREFFNRQGDLRHIKKL-------------------------RYWPLDKVLHDKYSFPAQ----------------
...||  . ..   |.        ..|..|. . ....|..                           |.  | ..... .                   
FKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYE

----------------DAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
                . ... ..|. .| .  |||.|| |.| ||. 
EKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase SRPK_d.AA CLK 79-461 22 2.6e-65 194.51 In-house 1-289 (350) Show / Hide 
Range on Protein: 79-461
Range on HMM: 1-289/350
Sequence Identity: 22% (90 aa)

YVVQRKVGWGHFSTVWLAWDTQQ-KSYVALKVQKSAKHYTEAAFDEIS-ILKQIADG-DPSNSKC--VVKLLDHFKH-SGPNGQHVCMVFEFLGDNLLTI
|..  ..| | |..|   ||..  |.|||||. .... |.|||  ||. |.|.|.   || | .   ..|..| |..  |    |.|.||| .| ..   
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHG----HICIVFELYGLSIYDF

IKLYN------YRGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLLTLP-LDPSKDPLKSGAPLILSKPAAAAAAATATAGVTSSSQPLSKSQK
.|  |      |...|.  ..... |..  .  ||  ....|||||||| ... . .                               |  .. .    |
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFVDSRF-------------------------------THFDCTFKYNHK

KKLKKKAAKDKTGKDKDMDKAAEAMVATVDATAAAVESGKGGSDGAPRHENHKIHADEATGAADAQAPGEAPRLANKHEKRLKVTDLGEL-DLRCKIVDL
||..                                                                        |      | ..  . ..  ...| 
KKIN------------------------------------------------------------------------KKS-NNCVCHYWHVKNTHICVIDF

GNAC---WTYKQFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLG-RMPRKVSLGGR---FSREFF
|.|      .   .  ..||.|| ||| ||. .|.| |.||..|  ||| ||. ||. |.        .|||.| ...|   |   .   |    ....|
GSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF

NRQG
....
YHNR
Kinase SRPK_d.AA S_TKc 79-519 16 3.2e-57 197.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 79-519
Range on HMM: 1-231/231
Sequence Identity: 16% (78 aa)

YVVQRKVGWGHFSTVWLAWDTQQKSYVALKVQKSAKHYTEAAFDEISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGD---NLLTIIKL
| . ||.| | |..|......  . .||.|. |      | .  ||.|||.       . . .|||.|.| .     .|..||.|...    .|...|| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKK

YNYRG----LPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLLTLPLDPSKDPLK-----SGAPLILSKPAAAAAAATATAGVTSSSQPLSKSQKK
....|    .|  ... .  ||. .|.|.|..  ||| ||||||.||.         .|     . . |                               
RGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-------HIKICDFGLARQL-------------------------------

KLKKKAAKDKTGKDKDMDKAAEAMVATVDATAAAVESGKGGSDGAPRHENHKIHADEATGAADAQAPGEAPRLANKHEKRLKVTDLGELDLRCKIVDLGN
                                                                                                    
----------------------------------------------------------------------------------------------------

ACWTYKQFTNDIQTRQYRSPEVLLGCKYST-PVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGGRFSREFFNRQGDLRH
        |  . |. |..||||   .|.. ..|.||. |...|...|  .|.            ....|....|                         
--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG-------------------------

IKKLRYWPLDKVLHDKYSFPAQDAQELAEFLCPLLDFVADKRPTAGQCLL-------HPWV
                        .|. .|.. .|..  .||||| ..|        |||.
-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SRPK_d.AA DYRK 79-218 35 9.9e-35 121.71 In-house 1-137 (320) Show / Hide 
Range on Protein: 79-218
Range on HMM: 1-137/320
Sequence Identity: 35% (50 aa)

YVVQRKVGWGHFSTVWLAWDTQQKSYVALKVQKSAKHYTEAAFDEISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGDNLLTIIKLYNY
| .    | | |. |  .||.. . .||.|. .. | .   | .||.||. . . || ... .|...|.|.|     .|.|.||| |  ||   .| .. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHR----NHLCIVFELLSMNLYEFLKNNHF

RGL-PLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLL
.|. .|  |..   ||| .|..||.  .||| ||||||..|
QGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIML
Kinase SRPK_d.AA DYRK2 79-218 36 5.5e-29 91.14 In-house 1-135 (318) Show / Hide 
Range on Protein: 79-218
Range on HMM: 1-135/318
Sequence Identity: 36% (51 aa)

YVVQRKVGWGHFSTVWLAWDTQQKSYVALKVQKSAKHYTEAAFDEISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGDNLLTIIKLYNY
| .    | | |  |  . |   | .||.|.    | . . |  || ||. |   |. |.  .|..|| |   .    |.|..|| |. ||   ||  ..
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKNHF

RGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLL
 |. |  |     .|| .|. ||.   ||| ||||||.||
QGFSLQLVRRFAHSILQCLRFLHKN-NIIHCDLKPENILL
Kinase SRPK_d.AA Ciliate-E2-Unclassified 79-519 13 7e-29 97.32 In-house 1-352 (352) Show / Hide 
Range on Protein: 79-519
Range on HMM: 1-352/352
Sequence Identity: 13% (73 aa)

YVVQRKVGWGHFSTVWLAWDTQQKSYV-----ALKVQKSAKHYTEAAFDEISILKQIADGD----------------PSNSKCVVKLLDHFKHSGPNGQH
| .... | | |..|... . .|| ..     . |.|. .... .   ... ..|..                     ... ..||....|.      |.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDK----QN

VCMVFEFL-GDNLLTIIKLYNY---------------RGLPLPMVK-----QLSMQILIGLDYLHRQLSIIHTDLKPENVLLTLPLDPSKDPLKSGAPLI
...| |.. | .|. .|| ..                . ..   .|     ..  ||| ||.|||... ||| |.||||.|..                 
IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-------------

LSKPAAAAAAATATAGVTSSSQPLSKSQKKKLKKKAAKDKTGKDKDMDKAAEAMVATVDATAAAVESGKGGSDGAPRHENHKIHADEATGAADAQAPGEA
                                                                                                    
----------------------------------------------------------------------------------------------------

PRLANKHEKRLKVTDLGELDLRCKIVDLGNA------------------CWTYKQFTNDIQTRQYR----SPEVLLGCKYSTP----VDIWSFACLVFEL
                    ...|| |.|..                   | .. ..  ..| .|     .|||| |..|...    .||||. .. .|.
-------------------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM

ATGDVLFDPHSGDQ--------------FDKDEDHLALMIELLGRMPRKVSLGGRFSREFFNRQGDLRHIKKLRYWPLDKVLHDKYSFPAQDAQELAEFL
 .|   |.  . .|              .   .. ..  |.     ...                                 ... |. |.|  .  ..|
LFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ--------------------------------IPKHWSPEAKDFIN--DLL

CPLLDFVADKRPTAGQCLLHPWV
. .|.   .||.|. | | ||| 
QKMLKKNPNKRITFEQILNHPWF
Kinase SRPK_d.AA DYRK1 79-221 34 9.5e-28 94.19 In-house 1-140 (321) Show / Hide 
Range on Protein: 79-221
Range on HMM: 1-140/321
Sequence Identity: 34% (49 aa)

YVVQRKVGWGHFSTVWLAWDTQQKSYVALKVQKSAKHYTEAAFDEISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGDNLLTIIKLYNY
| ..  .| | |  |  |.|.|.. |||.|. |  | . . |  || .|  .   |. .   .|.|  ||..      |.|.|||.|  ||  ...  ..
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNTHF

RGLPLPMVKQLSMQILIGLDYLHR-QLSIIHTDLKPENVLLTLP
||  | .....  |..  | ..    |.||| ||||||.||  |
RGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNP
Kinase SRPK_d.AA DYRK 360-519 26 2.8e-26 93.65 In-house 147-320 (320) Show / Hide 
Range on Protein: 360-519
Range on HMM: 147-320/320
Sequence Identity: 26% (51 aa)

KIVDLGNACWTYKQFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGG--RFSREFF
|..| | .|   ....  || | ||.|||.|||.|....|.||. | . || || .||   .|.      | ||...|.|| .|...   |  |. ..||
KVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENEY---DQLACIMEVLGMPPKWMIDKGRCRRKHKFF

NRQGDLRHIKKLRYWPLDKVLHDKY----------------------------SFPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
..         ..|  .|..   ..                             .  .| ...  |.  .|..  .||.|. | | |||.
DC---------FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase SRPK_d.AA DYRK2 360-519 28 1.8e-24 76.19 In-house 144-318 (318) Show / Hide 
Range on Protein: 360-519
Range on HMM: 144-318/318
Sequence Identity: 28% (53 aa)

KIVDLGNACWTYK-QFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGG------RF
|..| |  |  .  ..  .||.| ||.||| ||.||....|.||| | . || ||  ||    |.  .   | .|.|.|.|| || |. .        . 
KVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENEN---DQFACMMEVLG-MPPKKFFDTWFYIHCFR

SREFFNR-------------QGDLRHIKKL----RYWPLDKVLHDKYSFPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
 . |||.             . ..  ..|     |. |  | .  |....  . . ...|.   ..  ...| |. | | ||| 
RKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSW--KSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase SRPK_d.AA DyrkP 360-460 38 7.6e-21 64.77 In-house 148-242 (323) Show / Hide 
Range on Protein: 360-460
Range on HMM: 148-242/323
Sequence Identity: 38% (39 aa)

KIVDLGNACWTYKQFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGGRFSREFFNR
||.| | .|.        .| | || |||..||||   .|.||  |.. || || |||      | |     || .| ..| .|  .   ||  . || |
KIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF------QNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTR

Q
.
K
Kinase SRPK_d.AA Pkinase 79-218 28 6.1e-20 71.59 Pfam 1-141 (293) Show / Hide 
Range on Protein: 79-218
Range on HMM: 1-141/293
Sequence Identity: 28% (43 aa)

YVVQRKVGWGHFSTVWLAWDTQQKSYVALKVQKSAKHYTEA---AFD--EISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGDNLLTII
|.. ||.| | |..|... .      ||.|. |  .   .    ..   ||.|.| . .     ....|.|.| |      ..|..||.|...  |   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N-----HPNIVRLYDWFED----KDHIYMVMEYCEGGLY-VM

KLY------NYRGL--PLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLL
 |.      .....  .   .|    ||| ||.|.|.. .||| ||||||.|.
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-GIIHRDLKPENILI
Kinase SRPK_d.AA DYRK1 360-462 34 2.8e-17 56.79 In-house 146-242 (321) Show / Hide 
Range on Protein: 360-462
Range on HMM: 146-242/321
Sequence Identity: 34% (36 aa)

KIVDLGNACWTYKQFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGGRFSREFFNR
||.| | .| . .   . || | ||||||||| .|.. .|.||  |.. |. ||. ||   || .   . | .  ..| ||  |...   .  .. .|..
KIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SGSN---EVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEK

QGD
. |
DPD
Kinase SRPK_d.AA DyrkP 79-218 31 1.6e-15 46.95 In-house 1-139 (323) Show / Hide 
Range on Protein: 79-218
Range on HMM: 1-139/323
Sequence Identity: 31% (45 aa)

YVVQRKVGWGHFSTVWLAWDTQQKSYVALKVQKSAKHYTEAAFDEISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGDNLLTIIKLY--
| .   .|   ||      | |    . .|.    | | . . ||| .|. |        | |..  | | |      |. .. | | |||    |    
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHK----EHLFIITELLKDNLYEFYKFNRE

--NYRGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLL
    |   .  ....  ||||.|||.|  | .|| ||||||.|.
NEQQRYFTVGRLQKITQQILIALDYIH-SLRLIHCDLKPENILM
Kinase SRPK_d.AA CDK4 123-219 33 2.2e-15 49.02 In-house 50-144 (290) Show / Hide 
Range on Protein: 123-219
Range on HMM: 50-144/290
Sequence Identity: 33% (33 aa)

EISILKQIADGDPSNSKCVVKLLDHFKHSGPNG--QHVCMVFEFLGDNLLTIIKLYNYRGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLLT
|||.... .  .  |   .|||.| .. . . .    . ||||     | | .      |.| . .|... |.| |.|.||   .||| ||||.|.|.|
EISVMRHLCQFEHPN---IVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSH-RIIHRDLKPQNILVT
Kinase SRPK_d.AA CDK 372-417 42 7.6e-15 43.77 In-house 174-225 (284) Show / Hide 
Range on Protein: 372-417
Range on HMM: 174-225/284
Sequence Identity: 42% (22 aa)

KQFTNDIQTRQYRSPEVLLGCK-YS--TPVDIWSFACLVFELAT---GDVLF
. .|. . |. ||.||.|||.| ||  ||.|.||. |   |..|   .  ||
RTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLF
Kinase SRPK_d.AA Pkinase 356-441 24 1.5e-14 52.58 Pfam 144-233 (293) Show / Hide 
Range on Protein: 356-441
Range on HMM: 144-233/293
Sequence Identity: 24% (23 aa)

DLRC----KIVDLGNAC---WTYKQFTNDIQ-TRQYRSPEVLL-GCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGR
.  .    || | | |.   .  .. ....  |. |..|||.. | .|...||.||. |...|...|  .|. ... . |.  |..... . .|.
NGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGP
Kinase SRPK_d.AA CDK4 383-410 57 1.5e-12 39.21 In-house 175-202 (290) Show / Hide 
Range on Protein: 383-410
Range on HMM: 175-202/290
Sequence Identity: 57% (16 aa)

YRSPEVLLGCKYSTPVDIWSFACLVFEL
||.|||||   | ||||.|| .| ..|.
YRAPEVLLQSYYNTPVDMWSVGCIFAEM
Kinase SRPK_d.AA CDK 123-219 27 2.5e-12 35.61 In-house 58-142 (284) Show / Hide 
Range on Protein: 123-219
Range on HMM: 58-142/284
Sequence Identity: 27% (29 aa)

EISILKQIADGDPSNSKCVVKLLDHFKHSGPNG-------QHVCMVFEFLGDNLLTIIKLYNYRGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPEN
|||.||..        . .|||.| . .. .           . ||||..   | ....           .| . .|.| ||.|.|..  |.| |||| |
EISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSN-WIMHRDLKPQN

VLLT
 |..
ILIN
Kinase SRPK_d.AA TyrKc 79-519 11 2.1e-07 -102.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 79-519
Range on HMM: 1-280/280
Sequence Identity: 11% (56 aa)

YVVQRKVGWGHFSTVWLAWDTQQKSYVALKVQKSAKHYTEAAFDEISILKQI-ADGDPSNSKCVVKLLDHFKHSGPNG---QHVCMVFEFL-GDNLLTII
 .  .| | |.| .|...  .     || |. |. .   |.  .|..|....       . ...|.|.    ..| |    . ...|.|.  . .|.  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KLYNYRGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLLTLPLDPSKDPLKSGAPLILSKPAAAAAAATATAGVTSSSQPLSKSQKKKLKKKAA
. .  . |...   . . ||  | .|||..  .|| ||   |.|.. ..                                                   
RKHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH---------------------------------------------------

KDKTGKDKDMDKAAEAMVATVDATAAAVESGKGGSDGAPRHENHKIHADEATGAADAQAPGEAPRLANKHEKRLKVTDLGELDLRCKIVDLGNACWTYKQ
                                                                                    ..|| | | .   |  
------------------------------------------------------------------------------------TVKISDFGLSRDIYDD

----FTNDIQTR----QYR--------SPEVLLGCKYSTPVDIWSFACLVFELAT-GDVLFDP---HSGDQFDKDEDHLALMIELLGRMPRKV----SLG
       |  .     . .        .||..  .|..|  |.|||  . .|. | |.        .    . .... ...  .   ... .     |  
DQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ----MMSNQEVIEYVKQGYRMPQPPNDYPMS--

GRFSREFFNRQGDLRHIKKLRYWPLDKVLHDKYSFPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
                                  |     .|. .      .. ...|||  ..  |   
----------------------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase SRPK_d.AA Pkinase 474-519 20 5.2e-07 25.87 Pfam 227-293 (293) Show / Hide 
Range on Protein: 474-519
Range on HMM: 227-293/293
Sequence Identity: 20% (14 aa)

LDKVLHDKYSFPAQDA---------------------QELAEFLCPLLDFVADKRPTAGQCLLHPWV
...... ...|. .                       .|. .|.. .|..   ||||| |.| |||.
ICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SRPK_d.AA CDK 466-519 20 2.2e-05 12.99 In-house 252-284 (284) Show / Hide 
Range on Protein: 466-519
Range on HMM: 252-284/284
Sequence Identity: 20% (11 aa)

IKKLRYWPLDKVLHDKYSFPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
..|| ..                     ..|. .| .  .|| .| |.| ||. 
VTKLPDY---------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase SRPK_d.AA CDK4 493-519 37 9.2e-05 12.03 In-house 264-290 (290) Show / Hide 
Range on Protein: 493-519
Range on HMM: 264-290/290
Sequence Identity: 37% (10 aa)

AEFLCPLLDFVADKRPTAGQCLLHPWV
...|   | .  .||..| ||| ||. 
DDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase SRPK_d.AA Pkinase_Tyr 385-412 39 0.000289 15.07 Pfam 182-209 (270) Show / Hide 
Range on Protein: 385-412
Range on HMM: 182-209/270
Sequence Identity: 39% (11 aa)

SPEVLLGCKYSTPVDIWSFACLVFELAT
.||..  .|..|  |.|||  | .|. |
APECINYGKFTTKSDVWSFGVLMWEIFT
Kinase SRPK_d.AA DyrkP 506-519 57 0.002936 5.82 In-house 310-323 (323) Show / Hide 
Range on Protein: 506-519
Range on HMM: 310-323/323
Sequence Identity: 57% (8 aa)

KRPTAGQCLLHPWV
.||||   | |||.
RRPTAKEALQHPWF
Kinase SRPK_d.AA CDK 79-108 34 0.003829 5.72 In-house 1-35 (284) Show / Hide 
Range on Protein: 79-108
Range on HMM: 1-35/284
Sequence Identity: 34% (12 aa)

YVVQRKVGWGHFSTVWLAWDTQQK-----SYVALK
|    |.| |.. .|  | |.|..      .||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALK
Kinase SRPK_d.AA CLK 506-519 42 0.014953 2.66 In-house 337-350 (350) Show / Hide 
Range on Protein: 506-519
Range on HMM: 337-350/350
Sequence Identity: 42% (6 aa)

KRPTAGQCLLHPWV
||.|... | ||. 
KRITCKDALQHPFF