Gene WNK_a (S.moellendorffii)

WNK_a

Species: S.moellendorffii
Alias: WNK_a
External Links:
Annotation:

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
WNK_a.AA Protein None 635 None Fasta, JSON
WNK_a.NA RNA None 1908 None Fasta, JSON
WNK_a.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of WNK_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase WNK_a.AA WNK 27-284 50 1.9e-139 453.19 In-house 2-261 (261) Show / Hide 
Range on Protein: 27-284
Range on HMM: 2-261/261
Sequence Identity: 50% (134 aa)

RYSEVLGKGAFKAVYRAFDEVDGLEVAWNQVNVQDLLRSPDDLERLYSEVHLLKTLKHKNIIKFYTSWVDS---KRRNVNFITEIFTSGTLRQYRKKHKN
.. | .|.|.|| |||..|   . ||||. .  | | ..  .  |.  |. .|| |.| ||..||..|  .   |. ..  .||  |||||. | |  |.
KFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKN--ERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKK-CIVLVTELMTSGTLKTYLKRFKK

VDMKAVKNWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNYGEVKIGDLGLA-TILRQAHAAHSVIGTPEFMAPELYEEEYDELVDIYSFGMCVLEM
.  |  . | ||||.|| .||.  | |||||||||||||..|  |.||||||||| |  .. . | ||||||||||||.||| ||| ||.|.||||.|||
MKPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSF-AKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEM

VTFEYPYSECTNAAQIYKRVTSGKKPAAFEKVKDPEVRKFIEKCLAAVS-RRLPARELLMDPFL
.| |||||||.||||||..||.| ||..|.|...|||. .||||.      |  ...|| . |.
ATSEYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
S_TKc WNK_a.AA S_TKc 26-284 27 3.3e-63 217.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-284
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

GRYSEVLGKGAFKAVYRAFDEVDGLEVAWNQVNVQDLLRSPDDLERLYSEVHLLKTLKHKNIIKFYTSWVDSKRRNVNFITEIFTS--GTLRQYRKKHKN
 .  ...|||||  ||.. .  .| .||  ...           |....|. .||  .|.||.|.| ...|    .. ...|      |.|..| ||.. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

------VDMKAVKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNYGEVKIGDLGLATILRQAHAAHSVIGTPEFMAPELYEEEYDE-LVDIYSFGM
       .   .. ...||...| |.|||   ||||||| .||...    ..||.| |||..|      ....|||..||||.    |.   .|..|.| 
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGC

CVLEMVTFEYPYSECTNAAQIYKRVTSGKKPAAFEKVKDPEVRKFIEKCLA-AVSRRLPARELLM-------DPFL
.. ||.. . |..   . ....|..             .||.. ||.|||    ..|. | |.|        .|..
ILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase WNK_a.AA Pkinase 26-284 25 3.2e-56 197.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 26-284
Range on HMM: 1-293/293
Sequence Identity: 25% (77 aa)

GRYSEVLGKGAFKAVYRAFDEVDGLEVAWNQVNVQDLLRSPDDLERLYSEVHLLKTLKHKNIIKFYTSWVDSKRRNVNFITEIFTSG----TLRQYRK--
 .  ...|.|.|  ||.. .  .| .||  ......   . |   |. ||....| |.|.||...| .. |  .... ...|    |     |  | .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

KHKNV--DMKAVKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNYGEV----KIGDLGLATI--LRQAHAAHSVIGTPEFMAPEL--YEEEYDELV
.|...  ... .|....|||||| |.||.   ||||||| .||... | |..    ||.| |||    .   . .... |||..||||.    ..|.  |
RHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIYSFGMCVLEMVTFEYPYSEC-----TNAAQIYKRVTSGKKPAAFEKVKD-------------------PEVRKFIEKCLA-AVSRRLPARELLMDPFL
|..|.|  . ||.. . |....      .  |...|. ... .  ...  .                   .| ..||..||.   ..|. |...| .|..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase WNK_a.AA STE 26-284 22 1.3e-49 171.1 In-house 1-359 (359) Show / Hide 
Range on Protein: 26-284
Range on HMM: 1-359/359
Sequence Identity: 22% (81 aa)

GRYSEVLGKGAFKAVYRAFDEV---------------DGLEVAWNQVNVQD-------------LLRSPDDLERLYSEVHLLKTLK--HKNIIKFYTSWV
 .  |..|||||  ||.| .                  |  .|  |.|...               . .......  |. ..| ..  |.||.|.| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DSKRRNVNFITEIFTSGTLRQYRKKHKNVDM--------------KAVKNWARQILRG-LLYLHSHDPPIIHRDLKCDNIFVNGNYGEVKIGDLG
     .. . ... . |    |.|..  |. . . .              . ..  .||||.| | |||||   |||||.|..||..      ||. | |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG

LATILRQAHA-----------------AHSVIGTPEFMAPELYEEE-------YDELVDIYSFGMCVLEMVTFEYPYSECTNA-----AQIYKRVTS---
....| . .|                   ...||| .||||  . .       ||. .||.|.| ...||.| ..|... ..      ... ... .   
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------GKKPAAFEKVKD------------------PEVRKFIEKCLAAVSR-RLPARELLM--DPFL
      |. |   .....                  || . ||.|||    . |  | .||    ||.
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase WNK_a.AA CAMK 31-284 16 4.7e-49 155.8 In-house 1-425 (425) Show / Hide 
Range on Protein: 31-284
Range on HMM: 1-425/425
Sequence Identity: 16% (70 aa)

VLGKGAFKAVYRAFDEVDG------------LEVAWNQVNVQDLLR------------------------SPDDLERLYSEVHLLKT-------LKHKNI
.||.|.|  |.....  ..             .||   .. . |                          .| |......|....|.       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYTSWVDSK-----------------RRNVNFIT---EIFTSG----TLRQYRKKHKN---------------VDMKAVKNWARQILRGLLYLHSHDP
||.|  . |..                 .... ...   |  . |     | .| ..|..               .. . .. . |||. .. |.|||. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-

PIIHRDLKCDNIFVNGNY----------------GEVKIGDLGLATILRQAH------------------------AAHSVIGTPEFMA-PELYEEE---
 |.|||||..|| .. |.                . .|| | |.|..... .                          . . ||||.|| ||. . .   
-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------YDELVDIYSFGMCVLEMVTFEYPYSECT------------NAAQIYKRVTSGKKPAAFEKVKD----------------------PEV
            |.. .|. | |     |.. ..|. . .            |  ........||     .....                      .|.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

RKFIEKCLAA-VSRRLPARELLMDPFL
. .| |.|    ..|. . . | .|..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase WNK_a.AA NRBP 29-285 39 8.4e-47 161.81 In-house 2-261 (261) Show / Hide 
Range on Protein: 29-285
Range on HMM: 2-261/261
Sequence Identity: 39% (105 aa)

SEVLGKGAFKAVYRAFDEVDGLEVAWNQVNVQDLLRSPDDLERLYSEVHLLKTLKHKNIIKFYTSWVDSK--RRNVNFITEIFTSGTLRQY----RKKHK
 .| |    ...| | |. .| || || |.  ..     . |..      |  |.|.||.||   |.|.|  .  | ||||   || ..|.    .|.||
RDVPG---IDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHK

NVDMKAVKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNYGEVKIGDLGLATILRQAHAAHSVIGTPEFMAPELYEEEYDEL---VDIYSFGMCVL
|...|| | |. |||  | |||| ||||||  | || ||.  | | .|||     .| .. ...        |.|||    | ..|   ||||||||| |
NMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHN-GLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCAL

EMVTFEYPYSECTNAAQIYKRVTSGKKPAAFEKVKDPEVRKFIEKCLAAVSRRLP-ARELLMDPFLR
||  .|   | |.|.   |  ||      | . ..||  | ||.|||.    | | |||||  . | 
EMAVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase WNK_a.AA Ciliate-E2 26-284 17 1.3e-45 154.5 In-house 1-365 (365) Show / Hide 
Range on Protein: 26-284
Range on HMM: 1-365/365
Sequence Identity: 17% (69 aa)

GRYSEVLGKGAFKAVYRAFD-EVDGLEVAW--------------NQVNVQDLLRS-PDDLERLYSEVHLLK----------------TLKHKNIIKFYTS
    ...|.|.|  ||.. . .|. ..                 ....   . .  ....| . .| |...                .|.|.||||.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WVDSKRRNVNFITEIFTSGTLRQYRKKH-----------KNVDMKAVKNWARQILR---------------GLLYLHSHDPPIIHRDLKCDNIFVNGNYG
. . .. |. ...| .  |.|..| |..           |. ..| .|.  .|||.               .| ||||  . |||||.| .||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

EVKIGDLGLATILRQA--------------------------------HAAHSVIGTPEFMAPELYE----------EEYDELVDIYSFGMCVLEMVTFE
 .|| |.||.... .                                 . .....|||..|||| ..          ..||. .||.|.|..  ||.. .
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

YPYSECTNAAQIYKRVTSGKKPAAFEKVKDPEVR----------------------------KFIEK----CLAAV-SRRLP-ARELLMDPFL
.|.                     ... |. ...                             .| |    .|    . |.  . ..|  |..
PPF---------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase WNK_a.AA TKL 32-268 19 9.4e-42 145.03 In-house 1-349 (364) Show / Hide 
Range on Protein: 32-268
Range on HMM: 1-349/364
Sequence Identity: 19% (70 aa)

LGKGAFKAVYRA-FDEVD-------GLEVAWNQVNVQDLLRSPD-----------------------DLERLYSEVHLLKTLKHKNIIKFYTSWVDSK--
.|.|.|  ||.. .   .       | .||  . ....   . .                         ...  |. ... |.| ||..|. .  ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------RRNVNFITEIFTSGTLRQYRKKHKNVDMKAVKNWARQILRGLLYLHSHD------PPIIHRDLKCDNIFVNGNYGE-------------VK
           .  ...|    |.|. |        .    .||..| ||. ||||..      ||||||||| .||.|. |.               .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IGDLGLATIL--------------------RQAHAAHSVIGTPEFMAPELYE-----------------EEYDELVDIYSFGMCVLEMVTFEYPYSECTN
|.|.||.. .                    ... . ....||| .||||. .                 .||.| .|.||||..  |..| . ||..  .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

AAQI---------YKRVTSGKKPAAF-----------EKVKDPEVRKFIEKCLAA
  .|         ....  |..|              ..  .|...| ...| ..
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDH
Kinase WNK_a.AA STE11 30-284 28 2e-41 143.98 In-house 5-303 (303) Show / Hide 
Range on Protein: 30-284
Range on HMM: 5-303/303
Sequence Identity: 28% (86 aa)

EVLGKGAFKAVYRAFDEVDGLEVAWNQVNVQDLL----RSPDDLER------LYSEVHLLKTLKHKNIIKFYTSWV-DSKRRNVNFITEIFTSGTLRQYR
|..|||||  ||....   | ..|  |. .|.         . ..       . .|. |.|.|.||||...| . . |... .|| . |    |.|..  
EIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSML

K-KH-K-NVDMKAVKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNYGE-VKIGDLGLATILRQAH--AAH---------SVIGTPE--------F
. |  . . | . ...  .|||.|| |||||   |||||.| .||...  .|  .|..| | |. | . .  ...         |. |||         .
RHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDS-DGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMW

MAPELYE-EE---YDELVDIYSFGMCVLEMVTFEYPYSECTN--AAQIYKRVTS-GKKPAAFEKVKD-----PEVRKFIEKCLAAVSR-RLPARELLMDP
|||| .  |    |.  .|| |.| .|.||.|   |......  .|...| ... .  |   |..       .| | |. .|.      |  |..||..|
MAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHP

FL
|.
FI
Kinase WNK_a.AA NEK 27-284 26 1.4e-38 133.65 In-house 2-286 (286) Show / Hide 
Range on Protein: 27-284
Range on HMM: 2-286/286
Sequence Identity: 26% (77 aa)

RYSEVLGKGAFKAVYRAFDEVDGLE-----VAWNQVNVQDLLRSPDDLERLY-SEVHLLKTLKHKNIIKFYTSWVDSKRRNVNFITEIFT-SGTLRQY--
.. ...|.|.|  ||.. .  || .     ..| ..|.. .  |. . . .. .||..|| ||| ||.|.| |... .    . . |     |.| |   
EIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNM--SEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK

-RKKHK----NVDMKAVKNWARQILRGLLYLHSH-DP--PIIHRDLKCDNIFVNGNYGE---VKIGDLGLATILR-QAHAAHS-VIGTPEFMAPELY-EE
  ||.|    . . . . .|  |.. .| |.|..  |   |.|||.|. ||| . |  .   |||||.|.. .|   . .|.. ..||| .|.||.  ..
SIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

EYDELVDIYSFGMCVLEMVTF--EYPYSECT--NAAQIYKRVTSGKKPAAFEKVKDP-----EVRKFIEKCLA-AVSRRLPARELLMDPFL
 |.. .|| |.| .. ||.|.  . |  | .  |  . |.... |     .... .      . ...|...|    . |  ....| .||.
PYNNKSDIWSLGCVLYEMCTLKPKHPF-EAWDMNMPSLYMKIMKG---PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase WNK_a.AA Ciliate-E2-Unclassified 27-284 20 1.1e-36 124.82 In-house 2-352 (352) Show / Hide 
Range on Protein: 27-284
Range on HMM: 2-352/352
Sequence Identity: 20% (71 aa)

RYSEVLGKGAFKAVYRAFDEVDGLEV-----AWNQVNVQDLLRSPDDLERLYSEVHLLKT----------------LKHKNIIKFYTSWVDSKRRNVNFI
.  ...|.|.|  ||.. .. .. ..     .  . .. ...    | | . .. .. .                 | |..... .  ... .. |. ..
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TEIFTSGTLRQYRKKHKN-----------------VDMKAVK-----NWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNYG--EVKIGDLGLATILR
.| .  |.|.|| || |.                 .. ...|     ....||| || |||.    |||||.|..||... | .  ..|| |.|..  . 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

QA----------------HAAHSVIGTPEFM----APELYEE-EYD----ELVDIYSFGMCVLEMVTFEYPYS--ECT-----------------NAAQI
|                 . .....|||..|    |||.... .||    . .||.|.|..  ||.. .||..   |.                    .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

YKRVTSGKKPAA--FEKVKDPEVRKFIE----KCLAAVSR-RLPARELLMDPFL
... .. .|     . |  .||.  ||.    |.|      |. . ..|  |..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase WNK_a.AA ULK 29-266 23 2.2e-36 124.54 In-house 4-310 (329) Show / Hide 
Range on Protein: 29-266
Range on HMM: 4-310/329
Sequence Identity: 23% (74 aa)

SEVLGKGAFKAVYRAFDEVD----GLEVAWNQVNVQDLLRSPDD------LERLYSEVHLLKTLK----HKN----IIKFYT-SWVDSKRRNVNFITEIF
...||||.|  ||..... .    .  ||  ..  | . .....      .. | .|. ..|.||    |||    |.|.|  .. .    |. .|.|  
NHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH-NNIYIIMEYC

TSGTLRQYRKKHKNVDMKA----------VKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNYGE-----------VKIGDLGLATILRQA----H
  |.|.|| ||.|.  ..           ...  .||| |. .||.|   |||||.| .|| .. . .            .||.| |.|  .        
NGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

AAHSVI------GTPEFMAPELYEEE-----YDEL-VDIYSFGMCVLEMVTFEYPYSECTNAAQI----YKRVTSG--------KKPAAFE-----KVKD
 ...        ||| .|||.. ...     |..  .||.|.|.   ||.. ..|.... .  |.    .| .  .        |.|  |.     ..  
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PEVRKFIEKCL
||.. .| ..|
PECKDLIRRML
Kinase WNK_a.AA TyrKc 26-293 21 2.8e-17 56.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-293
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

GRYSEVLGKGAFKAVYRAFDEVDGLEVAWNQVNVQDLLRSPDDLERLYSEVHLLKTL--KHKNIIKFYTSWVDSKR-----RNVNFITEIFTSGTLRQYR
 .  ..|| |||  ||..      ..||   ..          .| ...|  ... |  .|.||...|   ....|       .  ..|    | |..| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKHKN-VDMKAVKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNYGEVKIGDLGLATILRQA---HAAHSVIGT-----PEF------MAPELY-E
.||.. . ||   ... || .|  ||||.  ..||||| . |. |. |.  |||.| ||.  .       ...... .       .      ||||   .
RKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

EEYDELVDIYSFGMCVLEMVTFEYPYSEC-----TNAAQIYKRVTSGKKPAAFEKV-------KDPEVRKFIEKCLAA-VSRRLPARELLMDPFLRCDGE
 .. .  |..||| |  |. |.  .  .       ........| .|. .   . .         .|. . ...| ..  . |   .|.           
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----------

RESL
.| .
HECF
Kinase WNK_a.AA Pkinase_Tyr 118-177 39 2.1e-07 25.71 Pfam 99-158 (270) Show / Hide 
Range on Protein: 118-177
Range on HMM: 99-158/270
Sequence Identity: 39% (25 aa)

RKK---HKNVDMKAVKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNYGEVKIGDLGLA
||.    ....||   ....|| .|. ||.|.   .||||| . |. |. |   |||.| |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA
Kinase WNK_a.AA Pkinase_Tyr 65-91 26 0.039415 7.84 Pfam 41-70 (270) Show / Hide 
Range on Protein: 65-91
Range on HMM: 41-70/270
Sequence Identity: 26% (8 aa)

SPDD--LERLYSEVHLLKTL-KHKNIIKFY
....  .| . .|. ..|.| .|.||...|
MHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase WNK_a.AA Pkinase_Tyr 196-244 26 0.18074 5.6 Pfam 181-232 (270) Show / Hide 
Range on Protein: 196-244
Range on HMM: 181-232/270
Sequence Identity: 26% (14 aa)

MAPE-LYEEEYDELVDIYSFGMCVLEMVTFE-YP-YSECTNAAQIYKRV-TSG
|||| . . .. .  |..||| .  |..|.   | | ..   ...|...  .|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDG
FRWNK_Wnk1 WNK_a.AA FRWNK_Wnk1 363-399 37 0.000414 12.18 In-house 43-79 (92) Show / Hide 
Range on Protein: 363-399
Range on HMM: 43-79/92
Sequence Identity: 37% (14 aa)

IHFPFDVEGDTALSVASEMVAELDLSDQDVTTIAEMI
| | || | |..  || |||.   . ..|. ..| .|
IEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSI