Gene IRAK-0_bt (S.moellendorffii)
IRAK-0_bt
Species: S.moellendorffii
Alias: IRAK-0_bt
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| IRAK-0_bt.AA | Protein | None | 683 | None | Fasta, JSON |
| IRAK-0_bt.NA | RNA | None | 2052 | None | Fasta, JSON |
| IRAK-0_bt.kin_dom | Protein Kinase Domain | None | 53 | None | Fasta, JSON |
Protein domains of IRAK-0_bt.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| B_lectin | IRAK-0_bt.AA | B_lectin | 224-275 | 47 | 1e-17 | 62.42 | Pfam | 45-109 (137) | Show / Hide |
Range on Protein: 224-275 Range on HMM: 45-109/137 Sequence Identity: 47% (31 aa) G-SF--VWST--NTGGSGA-Q--VLALESSGNLVIR-SKI--GDFLWQS--FDHPCDAVLPGMKL | | |||| || |||. .. . |||||.. .. ...|||| |||| | .|||||| GGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPTDTWLPGMKL |
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| B_lectin | IRAK-0_bt.AA | B_lectin | 164-265 | 27 | 0.000718 | -7.13 | SMART | 11-126 (126) | Show / Hide |
Range on Protein: 164-265 Range on HMM: 11-126/126 Sequence Identity: 27% (35 aa) HWETSSFE------------QVLILVHVA---QHQVAIAGKAEEAGRGAKAKA--NSKYLEWIREWSLEEDGAS--SDIGSFVWSTNTG-GSGAQVLALE . . |.|| ..|. . | .| . .. .|. ... || || .. .|| | .. |||.||. ..| |. | VSGNSLFEFYLGFFTFIMQWCNGIWYKNISNKQRTVVWVAQP---NRDNPVHDGNNSCYL------TMQSDGNLVIYD-NRPVWSSNTTRNNGNYVAVLQ SSGNLVIRSKI----GDFLWQSFDHP .||.||.. | |.||||||| DDGNFVIYDPDDNDSGNFIWQSFDHP |
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| Kinase | IRAK-0_bt.AA | TKL | 484-610 | 18 | 6.5e-21 | 72.05 | In-house | 1-283 (364) | Show / Hide |
Range on Protein: 484-610
Range on HMM: 1-283/364
Sequence Identity: 18% (52 aa)
IASGGVGTVFEGILS-------------VAVKRLESFSSQGYKQ-------------------------FKAEESH------------------------
| ||| |.|. |.. ||||.. | ... |. ||
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------YFLVYEYVANGY-----KPREDTRFKIVEEIARGMCYLHEECS-----TRVLHLDIKPQNLLLDENFG--------------VKIAEF
...|.||. .| . |.... .|||||.||| . ..| |.|..|.|.|||. .||. |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDF
GLSRMM-----------------------------R---------VRDKL----------------------DIYSFGILVLEVA
||||.| . | .. |.|||||. |..
GLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL
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| Kinase | IRAK-0_bt.AA | RIPK | 540-592 | 49 | 1.3e-17 | 56.6 | In-house | 109-160 (290) | Show / Hide |
Range on Protein: 540-592 Range on HMM: 109-160/290 Sequence Identity: 49% (27 aa) RFKIVEEIARGMCYLHEECSTR--VLHLDIKPQNLLLDENFGVKIAEFGLSRMMR |. .. ||..|||||| | ..|.| ||.| |.| || |||| |||. |. RCRMIHEISCGMCYLH---SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMM |
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| Kinase | IRAK-0_bt.AA | Dicty4 | 547-592 | 47 | 6.1e-17 | 53.2 | In-house | 121-165 (277) | Show / Hide |
Range on Protein: 547-592 Range on HMM: 121-165/277 Sequence Identity: 47% (22 aa) IARGMCYLHEECSTRVLHLDIKPQNLLLDENFGVKIAEFGLSRMMR .|||| .||. | ....|.|.|. ||| |.|. ||.. ||||..|. AARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMK |
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| Kinase | IRAK-0_bt.AA | TKL-Unique | 540-589 | 40 | 1.5e-16 | 55.01 | In-house | 112-165 (290) | Show / Hide |
Range on Protein: 540-589 Range on HMM: 112-165/290 Sequence Identity: 40% (22 aa) RFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDEN-----FGVKIAEFGLSR | |... ||.||.||| . . ..|.|.|..|.|.|.| . .||. ||||. RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK |
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| Kinase | IRAK-0_bt.AA | Trio | 552-586 | 38 | 5.1e-13 | 29.07 | In-house | 109-144 (258) | Show / Hide |
Range on Protein: 552-586 Range on HMM: 109-144/258 Sequence Identity: 38% (15 aa) CYLHEECSTRVLHLDIKPQNLLLDENFG----VKIAEFG .||| . ..||||||| |..... . .||. || HYLH---NCHILHLDIKPENMMMWHYNAGRPQIKICDFG |
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| Kinase | IRAK-0_bt.AA | Ciliate-C1 | 562-588 | 59 | 9.6e-13 | 28.87 | In-house | 150-176 (328) | Show / Hide |
Range on Protein: 562-588 Range on HMM: 150-176/328 Sequence Identity: 59% (16 aa) VLHLDIKPQNLLLDENFGVKIAEFGLS . |.|.|| |.|||||| ||| ||.. ICHRDLKPENILLDENFNLKIADFGFA |
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| Kinase | IRAK-0_bt.AA | CDC2 | 547-589 | 44 | 1.2e-12 | 34.64 | In-house | 112-151 (301) | Show / Hide |
Range on Protein: 547-589 Range on HMM: 112-151/301 Sequence Identity: 44% (19 aa) IARGMCYLHEECSTRVLHLDIKPQNLLLDENFGVKIAEFGLSR | .|....| . |..| |.||||.|.|.. .||| |||.| ILQGVHFCH---QRRIMHRDLKPQNILIDKKGNIKIADFGLAR |
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| Kinase | IRAK-0_bt.AA | DRK | 547-588 | 52 | 1.7e-12 | 38.67 | In-house | 107-147 (258) | Show / Hide |
Range on Protein: 547-588 Range on HMM: 107-147/258 Sequence Identity: 52% (22 aa) IARGMCYLHEECSTRVLHLDIKPQNLLLDENFGVKIAEFGLS .|.|| ||| | ..| | | ||| ||.. ||.| |||| CAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLS |
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| Kinase | IRAK-0_bt.AA | CDK | 549-601 | 33 | 2.1e-12 | 35.84 | In-house | 119-177 (284) | Show / Hide |
Range on Protein: 549-601 Range on HMM: 119-177/284 Sequence Identity: 33% (21 aa) RGMCYLHEECSTRVLHLDIKPQNLLLDENFG-----VKIAEFGLSRMMRVRDK----LDIYS ||. |.| | ...| |.||||.|...| .||| |||.| . .. . . |. RGLHYCH---SNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYT |
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| Kinase | IRAK-0_bt.AA | Pkinase | 537-591 | 32 | 3.2e-12 | 44.28 | Pfam | 107-162 (293) | Show / Hide |
Range on Protein: 537-591 Range on HMM: 107-162/293 Sequence Identity: 32% (19 aa) EDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDENFGV----KIAEFGLSRMM |.. ... .|.||. |.|.. ...| |.||.|.|.|.| . ||. |||.. . EWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQF |
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| Kinase | IRAK-0_bt.AA | CMGC | 547-589 | 27 | 5e-12 | 34.89 | In-house | 189-252 (513) | Show / Hide |
Range on Protein: 547-589 Range on HMM: 189-252/513 Sequence Identity: 27% (18 aa) IARGMC--YLHEECSTRVLHLDIKPQNLLLDEN--------------------FGVKIAEFGLSR | ||. |.| . ...| |.||.|.|...| . .||. |||.| ILRGLKLKYCHSHWG-NIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLAR |
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| S_TKc | IRAK-0_bt.AA | S_TKc | 478-683 | 16 | 1.9e-08 | -53.14 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 478-683 Range on HMM: 1-231/231 Sequence Identity: 16% (45 aa) KAFSAKIASGGVGTVFEGILSV-----AVKRLESFSSQGYKQFKAE------------------E-SHYFLVYEYVAN----------GYKP-------R . || .|. |.|. .. |.|.. .... | . .|...| ||. . ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP EDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDENFGVKIAEFGLSRMM---------------RVRD-KLDIYSFGILVLEVALSIPVCLAGG | . ... .|.... |.|. ..| |.||.|.|||| .||. |||.| . | |..|.|... | . | E-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP--- AQSSWRFEKLRSGKLMEMLEEKRARQEMEATSKAEKLLRIGVWCIQPDSQPNCGNPLT------LIDFV | |.|.. |. | . . .. |. | . |. . .. -QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| TyrKc | IRAK-0_bt.AA | TyrKc | 478-680 | 17 | 2.2e-07 | -103.26 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 478-680 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) KAFSAKIASGGVGTVFEGILS--VAVKRLESFSSQGYKQFKAE-----------------------E-------SHYFLVYEYVANG--------YK--P . |. .| |.|..|... |||| | . . . | | . ...| ||...| .. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL REDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDENFGVKIAEFGLSRMMRVR-----------------DK------------L--------- .. .. ||.|| |||. .. | |. | |..||. |||. ||||| | . CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS DIYSFGILVLEVALSIPVCLAGGAQSSWRFEK--LRSGKLMEMLEEK-RARQEME--------ATSKAEKLLRIGVWCIQPDSQPNCGNPLTLI |..|||.. |. . |.| . .. . ..| ... | .| . .... .. . | .|.. |. . .. DVWSFGVCMWEI-------FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQ-CWHEDPEDRPTFSEIHECF |
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| Kinase | IRAK-0_bt.AA | TKL-Unique | 480-505 | 37 | 0.004264 | 6.98 | In-house | 1-29 (290) | Show / Hide |
Range on Protein: 480-505 Range on HMM: 1-29/290 Sequence Identity: 37% (11 aa) FSAKIASGGVGTVFEGIL---SVAVKRLE |..|| .||.|.|. |. .||.|... FWNKIGEGGYGQVYKGKWRGYPVAIKQFH |
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| Kinase | IRAK-0_bt.AA | Trio | 541-550 | 50 | 0.004818 | 2.93 | In-house | 1-10 (258) | Show / Hide |
Range on Protein: 541-550 Range on HMM: 1-10/258 Sequence Identity: 50% (5 aa) FKIVEEIARG . ..|||.|| YTFQEEIGRG |
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| Kinase | IRAK-0_bt.AA | RIPK | 593-609 | 52 | 0.292375 | 0.01 | In-house | 205-221 (290) | Show / Hide |
Range on Protein: 593-609 Range on HMM: 205-221/290 Sequence Identity: 52% (9 aa) VRDKLDIYSFGILVLEV | | |.|||.|.. || VTPKYDVYSFAIVMWEV |
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