Cdk7_Dmel MLPNAN---DKT------------------------------------------------
CDK7_Mmus MAVDVK---SRA------------------------------------------------
cdk-7_Cele M----------S------------------------------------------------
KIN28_Scer MKV--------N------------------------------------------------
CDK7_Hsap MALDVK---SRA------------------------------------------------
Cdk7_Ddis M-----------------------------------------------------------
CDK7_Spur MEAWK----ANAEKEEESFLKILHSRMETSSAHGLPNIHRSSKSITKLFWLLLFLTGIGV
CC1G_00997_Ccin MDIVEQANAERQ------------------------------------------------
AqueK098_Aque M----------S------------------------------------------------
CDK7-2_Smoe MLEL--KNGIGA------------------------------------------------
CDK7-1_Smoe MLEL--KNGIGA------------------------------------------------
*
Cdk7_Dmel ------------------------------------------------------------
CDK7_Mmus ------------------------------------------------------------
cdk-7_Cele ------------------------------------------------------------
KIN28_Scer ------------------------------------------------------------
CDK7_Hsap ------------------------------------------------------------
Cdk7_Ddis ------------------------------------------------------------
CDK7_Spur ITWQVIALFKTYFAYEYTVSLEIKFNRSQEFPAITICNMNPVMKSKLEKADDSFRELFDT
CC1G_00997_Ccin ------------------------------------------------------------
AqueK098_Aque ------------------------------------------------------------
CDK7-2_Smoe ------------------------------------------------------------
CDK7-1_Smoe ------------------------------------------------------------
Cdk7_Dmel ------------------------------------------------------------
CDK7_Mmus ------------------------------------------------------------
cdk-7_Cele ------------------------------------------------------------
KIN28_Scer ------------------------------------------------------------
CDK7_Hsap ------------------------------------------------------------
Cdk7_Ddis ------------------------------------------------------------
CDK7_Spur NFQPPGPMDMVDQVVQGVGQVGGVFSSGVGSFMGSGGNSGGGVEANNAKTTQRPGSSTAG
CC1G_00997_Ccin ------------------------------------------------------------
AqueK098_Aque ------------------------------------------------------------
CDK7-2_Smoe ------------------------------------------------------------
CDK7-1_Smoe ------------------------------------------------------------
Cdk7_Dmel -----------------------------------------------ER-----------
CDK7_Mmus -----------------------------------------------KR-----------
cdk-7_Cele -----------------------------------------------RR-----------
KIN28_Scer -----------------------------------------------ME-----------
CDK7_Hsap -----------------------------------------------KR-----------
Cdk7_Ddis -----------------------------------------------DK-----------
CDK7_Spur GRRATDGNVEVAGSVEPPNGPSGPLSSQALCSRHQASGQPPNLREIQQRYGVRNLRGGSM
CC1G_00997_Ccin -----------------------------------------------RK-----------
AqueK098_Aque -----------------------------------------------KR-----------
CDK7-2_Smoe -----------------------------------------------KR-----------
CDK7-1_Smoe -----------------------------------------------KR-----------
.
Cdk7_Dmel ------------------------------------------------------------
CDK7_Mmus ------------------------------------------------------------
cdk-7_Cele ------------------------------------------------------------
KIN28_Scer ------------------------------------------------------------
CDK7_Hsap ------------------------------------------------------------
Cdk7_Ddis ------------------------------------------------------------
CDK7_Spur DLYKKGEMSANRGPTQKSMTSKKGVRTLCSPSLYLPLTLSHYVGFRSDLFRGRPSFGCSR
CC1G_00997_Ccin ------------------------------------------------------------
AqueK098_Aque ------------------------------------------------------------
CDK7-2_Smoe ------------------------------------------------------------
CDK7-1_Smoe ------------------------------------------------------------
Cdk7_Dmel ------------------------------------------------------------
CDK7_Mmus ------------------------------------------------------------
cdk-7_Cele ------------------------------------------------------------
KIN28_Scer ------------------------------------------------------------
CDK7_Hsap ------------------------------------------------------------
Cdk7_Ddis ------------------------------------------------------------
CDK7_Spur ANTSITPTRPTRPITDRAKTYITRPSRESVGFEIGLKAVETWQDRQKGDFFRKQSNDYLK
CC1G_00997_Ccin ------------------------------------------------------------
AqueK098_Aque ------------------------------------------------------------
CDK7-2_Smoe ------------------------------------------------------------
CDK7-1_Smoe ------------------------------------------------------------
Cdk7_Dmel ------------------------------------------------------------
CDK7_Mmus ------------------------------------------------------------
cdk-7_Cele ------------------------------------------------------------
KIN28_Scer ------------------------------------------------------------
CDK7_Hsap ------------------------------------------------------------
Cdk7_Ddis ------------------------------------------------------------
CDK7_Spur QQRLMVKLANKTIEERKSLGHSLDDMLLDCSWRGFPCSPANFTNIFDPQFGNCYIFNSGL
CC1G_00997_Ccin ------------------------------------------------------------
AqueK098_Aque ------------------------------------------------------------
CDK7-2_Smoe ------------------------------------------------------------
CDK7-1_Smoe ------------------------------------------------------------
Cdk7_Dmel ------------------------------------------------------------
CDK7_Mmus ------------------------------------------------------------
cdk-7_Cele ------------------------------------------------------------
KIN28_Scer ------------------------------------------------------------
CDK7_Hsap ------------------------------------------------------------
Cdk7_Ddis ------------------------------------------------------------
CDK7_Spur DGDTLTTNRPGPNYGLSMELFVQQDEYMEDQTEVAGFRVIIHHPSNMPFPSDDGIFVSPG
CC1G_00997_Ccin ------------------------------------------------------------
AqueK098_Aque ------------------------------------------------------------
CDK7-2_Smoe ------------------------------------------------------------
CDK7-1_Smoe ------------------------------------------------------------
Cdk7_Dmel ------------------------------------------------------------
CDK7_Mmus ------------------------------------------------------------
cdk-7_Cele ------------------------------------------------------------
KIN28_Scer ------------------------------------------------------------
CDK7_Hsap ------------------------------------------------------------
Cdk7_Ddis ------------------------------------------------------------
CDK7_Spur MVTAIGVRVVTAIGVRVVEIERLPEPYGLCKEDTKENIEDNIYYQNYNMSYSIQKKLFEK
CC1G_00997_Ccin ------------------------------------------------------------
AqueK098_Aque ------------------------------------------------------------
CDK7-2_Smoe ------------------------------------------------------------
CDK7-1_Smoe ------------------------------------------------------------
Cdk7_Dmel ------------------------------------YAKLSFLGEGQFATVYKARDTV-T
CDK7_Mmus ------------------------------------YEKLDFLGEGQFATVYKARDKN-T
cdk-7_Cele ------------------------------------YDTIKHLGEGQFANVYLAQDLE-S
KIN28_Scer ------------------------------------YTKEKKVGEGTYAVVYLGCQHS-T
CDK7_Hsap ------------------------------------YEKLDFLGEGQFATVYKARDKN-T
Cdk7_Ddis ------------------------------------YNIEALIGEGTYGVVSRATVKA-T
CDK7_Spur MIRSNEEMKRQIRGQSPSVWTRSNMAKLEIYFDEFNYEYIRQDPAYTFATVYKALDLQHD
CC1G_00997_Ccin ------------------------------------WLKDRKVGEGAYAVVYQGREAS-T
AqueK098_Aque ------------------------------------YRKLDILGEGQFATVYRAEDTERD
CDK7-2_Smoe ------------------------------------YVKGISLGEGTYGVVFKALDTQ-T
CDK7-1_Smoe ------------------------------------YVKGISLGEGTYGVVFKALDTQ-T
: :. * .
Cdk7_Dmel NQIVAVKKIKK-GSREDARDGINRTALREIKILQELQHENIIGLVDVFGQLSNVSLVFDF
CDK7_Mmus NQIVAIKKIKL-GHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDF
cdk-7_Cele GECVAIKKIKL-GSREEAKDGINRTAIREIKLLKEIHHDNIIGLRDVIGHRTSIQLVFDF
KIN28_Scer GRKIAIKEIKT-S---EFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDNLNLVLEF
CDK7_Hsap NQIVAIKKIKL-GHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDF
Cdk7_Ddis GQIVAIKKIRKILIQNQTDDGINFSAIREIKILQELKHDNVVNLLDIFAHKSNVYLVFEL
CDK7_Spur GKIVAVKKIKL-GHRSEAQDGINRTALREIKLLQEIKHENVIG-----------------
CC1G_00997_Ccin GRKVAIKKIKV-G---QFKDGLDMSAIREVKFLRELKHQNVIELLDVFSSKKNLNLVLEF
AqueK098_Aque NAIVAVKKIKI-GQRREARDGINRTALREIKLLQELHHPHILGLLDVLGHKSNISLIFDF
CDK7-2_Smoe NRTVAVKKIRL-G---KYKEGVHVTALREIKLLKELRDPNIIELIDVYPHKRNLHLVFEF
CDK7-1_Smoe NRTVAVKKIRL-G---KYKEGVHVTALREIKLLKELRDPNIIELIDVYPHKRNLHLVFEF
. :*:*:*: . :*:. :*:**:* *:*: . :::
Cdk7_Dmel MDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKI
CDK7_Mmus METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKL
cdk-7_Cele MDTDLEHVIKDKEIILMPAHIKNITMQMLLGLEFLHVHWILHRDLKPNNLLMNKMGRVKL
KIN28_Scer LPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKV
CDK7_Hsap METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKL
Cdk7_Ddis MQWDLQEVIEDKSIILKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSINGDLKL
CDK7_Spur ------VIIKDSSVVLTPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVLKI
CC1G_00997_Ccin LDTDLEIIIRDRSLVFLPADIKSWMAMTFRGLEFCHRNWILHRDLKPNNLLIASDGQLKI
AqueK098_Aque MDTDLEMIIKDKSLLLPPGVVKAYSLMILQGLEYLHAHWILHRDLKPNNLLINKDGVLKI
CDK7-2_Smoe MESDLEAVIRDRNILLSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKL
CDK7-1_Smoe MESDLEAVIRDRNILLSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKL
:*.* .::: . :* : *: * :::****:******. * :*:
Cdk7_Dmel GDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFM
CDK7_Mmus ADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFL
cdk-7_Cele TDFGLARFFGSPNRNYTHQVVTRWYRAPELLFGARSYGVGIDIWSVGCIIAELLLRNPIF
KIN28_Scer ADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYL
CDK7_Hsap ADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFL
Cdk7_Ddis ADFGLARQYGSPNKVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYL
CDK7_Spur GDFGLAKFYGSPNRIYTHQVVTRWYRCPELLFGARIYGTGVDMWAMGCILAELLLRVPFL
CC1G_00997_Ccin ADFGLARDFADPGYKMTCQVITRWYRPPELLYGCRYYGTGVDIWSVGCIFAELMLRIPYL
AqueK098_Aque TDFGLAKAYGSPNRIMTHQVVTRWYRSPELLFGARLYSTGVDLWAVGCIIAEMLLRLPFL
CDK7-2_Smoe GDFGLARIFGSPDRKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRRPFL
CDK7-1_Smoe GDFGLARIFGSPDRKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRRPFL
*****: * : :..: :** ****:*.: * .:*:*: * *:**::** * :
Cdk7_Dmel PGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNF-PGT---PLDNIFTAAGNDLI
CDK7_Mmus PGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF-PGV---PLQHIFIAAGDDLL
cdk-7_Cele PGESDIDQLVKIFNILGCPTPETWPNMTEMNSYVIIKPQTEYM---ALNYYFSAAPQDLL
KIN28_Scer PGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIY-PPPSRDELRKRFIAASEYAL
CDK7_Hsap PGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF-PGI---PLHHIFSAAGDDLL
Cdk7_Ddis PGTGEIDQLRKICSALGTPNESNWPGVTCLPNYIKFTDH-PAT---PFKQLFTAASDEAI
CDK7_Spur PGESDLDQLSRIFQTMGTPSEEEWPNMSALADYIEFKKF-PGT---PLRDIFTAGTDDLL
CC1G_00997_Ccin AGESDMDQLKTIFRALGTPTEEEWPGHTKLPDYVPVGQF-PKT---PLRDLFTAASADAL
AqueK098_Aque PGETDLGQLSTIFEFFGSPNEENWPSVKSLPDYVEFKPS-PPQ---SFRDVFSAAGDDLI
CDK7-2_Smoe QGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEFQFT-PAP---ALRSLFPMATEDAL
CDK7-1_Smoe QGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEFQFT-PAP---ALRSLFPMATEDAL
* ::.*: :* * ** : * . : * . :
Cdk7_Dmel HLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPSAILAAK-E-GANPQTGDT
CDK7_Mmus ELIQGLFLFNPCTRTTASQALKTKYFSNRPGPTPGCQLPRPNCPVEALKE-PANPTV---
cdk-7_Cele DLMAGMWTFDPIKRLTCTQSLQMEYFRTQPFCCLDEELPLPKKQQ---------PQ----
KIN28_Scer DFMCGMLTMNPQKRWTAVQCLESDYFKELPPPSDPSSI----------------------
CDK7_Hsap DLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKE-QSNPAL---
Cdk7_Ddis DLISKMLLFNPSNRISAADALNHPYFTSGVKHTNPADLPVPFAKKASLL--QQRQVLAQV
CDK7_Spur TLLKGLLLMDPCRRCKATEALKMPYFYTKPAPTPGHLLPRPGMVAAAANG-KQQPKL---
CC1G_00997_Ccin NLLSKCLVYEPRKRISAREALNHPYFFALPYPTHPSKLPKPASKHATPPLGEVDGNAAGG
AqueK098_Aque HLLESCMKLDPSKRCTASQALQSSYFSNPPGPTPGPRLPMPRSRKEIEAD-IEHEIM---
CDK7-2_Smoe DLLSKMFAFDPKARITAQQALEHRYFSTDPAPTKAHLLLRPASKAEGMR--P-PPELASP
CDK7-1_Smoe DLLSKMFAFDPKARITAQQALEHRYFSTDPAPTKAHLLLRPASKAEGMR--P-PPELASP
:: :* * .. :.*. ** :
Cdk7_Dmel K-P--ALKRKLVETTVRGN-----------------------------------------
CDK7_Mmus -----ATKRKRAEALEQ-------------------------------------------
cdk-7_Cele ------KRSRRLD--DDG------------------------------------------
KIN28_Scer ------------------------------------------------------------
CDK7_Hsap -----AIKRKRTEALEQ-------------------------------------------
Cdk7_Ddis QQQLLQKQQQQQQQ-----------------------------Q----------------
CDK7_Spur -----GSKRKMADDIGTAAQCYLLGQQLKRHVLRIPEGVQNTYPLADGASCLLTPTEYGS
CC1G_00997_Ccin KKR-KGTKRKLSSP------------------------------LEDG------------
AqueK098_Aque -----ASRKRALDDSQEG------------------------------------------
CDK7-2_Smoe KEPVVLSPPAKARRISL-FP----GVAG-------AEHIHHSKESKDGSSAA-TVGETPS
CDK7-1_Smoe KEPVVLSPPAKARRISL-FP----GVAG-------AEHIHHSKESKDGSSAA-TVGETPS
Cdk7_Dmel -------------------GLAQKKRLQ-F
CDK7_Mmus --------------------GILPKKLI-F
cdk-7_Cele --------------------TRPVRRLNFD
KIN28_Scer ---------------K----------IR-N
CDK7_Hsap --------------------GGLPKKLI-F
Cdk7_Ddis ---QQQIQSQPEPI-QVDNVEQTQQAQQ-V
CDK7_Spur YADGMFRMPGQYRLSHT-CAEVMPIAVR-L
CC1G_00997_Ccin --------KGRSIARRLDFG-KAAPPTS-P
AqueK098_Aque --------------------QKVAKRLN-F
CDK7-2_Smoe DHSGMAITDRSYLKRKLDMDVHFEDERH-V
CDK7-1_Smoe DHSGMAITDRSYLKRKLDMDVHFEDERH-V