Protein (view, download) , Domain (view, download)
KHS2_Hsap       MN----------PGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE
KHS1_Hsap       MEAPL------RPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE
HPK1_Hsap       MDV---------VDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKME
GCK_Hsap        MA----------LLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLD
KHS2_Mmus       MN----------PGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE
KHS1_Mmus       MEAPL------RPAADILRRNPQHDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE
HPK1_Mmus       MAL---------VDPDIFNKDPREHYDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKME
GCK_Mmus        MA----------LLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLD
CG7097_Dmel     MAAAHSHHNANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLE
ZC404.9_Cele    MSA-----------DVIKRSNPADDYELLQRVGSGTYGEVYKARDIRSDSLAAVKVVKLE
KHS_Spur        MSQT--------PSAEISRKNPLEDFELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIE
AqueK230_Aque   MAISP-----DGILPNISRKNPERDFELVKQIGSGTYGEVYKAKLVKTGQLCALKIIKIE
AqueK231_Aque   MAST--------LLPEIQLKDPVQDFELLSQIGSGGYGVVYKAKTVSDGQLCALKIIKIK
                *               :   :*   ::*:.::*.* ** *:**:      * *:*::*:.

KHS2_Hsap       PGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG-PLS
KHS1_Hsap       PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTG-PLS
HPK1_Hsap       PDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLS
GCK_Hsap        PGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATG-PLE
KHS2_Mmus       PGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG-PLS
KHS1_Mmus       PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTG-PLS
HPK1_Mmus       PDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLS
GCK_Mmus        PGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATG-PLE
CG7097_Dmel     PSDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTG-PLT
ZC404.9_Cele    AGDNFAVIQQEIMVIRECSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTG-PLS
KHS_Spur        PGDDFTIIQQEILMMKDCRHANIVGYFGSYLRREKLWIAMEYCGGGSLQDIYHMTG-HLA
AqueK230_Aque   PGEDFNIIQQEILILSECKHANIVGYLGSYLRxxxxxxxxxxxxxxxxxxxxxxxx-xxx
AqueK231_Aque   AGEDFNLIQKEISILSHCKHPNIVGYYSSYLRKDKLWISMEFCEAGSLYNMMHVQHSGLN
                ..::.  :*:** ::  * * *::.* .**:

KHS2_Hsap       ELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRK
KHS1_Hsap       ELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK
HPK1_Hsap       ELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRL
GCK_Hsap        ERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRR
KHS2_Mmus       ELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRK
KHS1_Mmus       EMQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK
HPK1_Mmus       ELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRL
GCK_Mmus        ERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRR
CG7097_Dmel     EVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRK
ZC404.9_Cele    ELQIAFVCRETLRGLNYLHNMGKIHRDIKGANILLSSSGDVKLADFGVAAQITATIGKRK
KHS_Spur        ELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRK
AqueK230_Aque   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
AqueK231_Aque   ELQIAFVCKETLQGLTYLHERNILHRDIKSANILLTHDTVVKLADFGIATQLTQTMGKRK


KHS2_Hsap       SFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKS
KHS1_Hsap       SFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKS
HPK1_Hsap       SFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKS
GCK_Hsap        SFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKS
KHS2_Mmus       SFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKS
KHS1_Mmus       SFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKS
HPK1_Mmus       SFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKS
GCK_Mmus        SFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKS
CG7097_Dmel     SFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKS
ZC404.9_Cele    SFIGTPYWMAPEVACVEKRGGYGMQCDVWATGITAIELGECQPPLFDLHPMQVLYLMTKS
KHS_Spur        SFIGTPYWMAPEVAAVERKGGYDFQCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKS
AqueK230_Aque   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxALYLMTKR
AqueK231_Aque   TFIGTPYWMAPEVAAVDKKGGYNQKCDIWSLGITAIELAEMQPPMNDLHPFRSVTIN---
                                                                     : :

KHS2_Hsap       NFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQ-HPFVTQ---HLTRSLAIEL
KHS1_Hsap       NFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLT-HTFVAQP--GLSRALAVEL
HPK1_Hsap       GYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLS-HQLVSQP--GLNRGLILDL
GCK_Hsap        SFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQ-HPFTTQ---QLPRALLTQL
KHS2_Mmus       NFQPPKLKDKLKWSNSFHHFVKMALTKNPKKRPNAEKLLQ-HPFVTQ---PLTRSLAIEL
KHS1_Mmus       NFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLT-HTFVGQP--GLSRALAVEL
HPK1_Mmus       GYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLS-HQLVSQP--GLNRGLILDL
GCK_Mmus        SFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAERLLQ-HPFTTQ---HLPPALLTQL
CG7097_Dmel     GFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQ-HPFVQC---EMSLRVAKEL
ZC404.9_Cele    GYKPPHLKDKHRWTPLFHDFVRQCLTKNPKKRPSPEKLLTSHPFVLG---SLSARMTRDL
KHS_Spur        NFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQ-HPYFQDNIDRLTEQTMRQL
AqueK230_Aque   NFRPPTLQHKNKWSNNFHDFLSQALKKDPKIRPNADDLLK-HEFVHR---DLSGLLMVPL
AqueK231_Aque   -------------------------------------IL-WDDFVKR---DLSGLLMGPL
                                                     :*  .         :       *

KHS2_Hsap       LDKVNNPDHS--T-Y-----HDFDDDDP----EPL----VAVPHRIHSTSRNVREEKT--
KHS1_Hsap       LDKVNNPDNHA-H-Y-----TEADDDDF----EPH----AIIRHTIRSTNRNARAERT--
HPK1_Hsap       LDKLKNPGKGPS--I-----GDIEDEEP----ELP----PAIPRRIRSTHRSSSLGIP--
GCK_Hsap        LDKASDPHLG--T-P------SPEDCEL----ETY----DMFPDTIHSRGQHGPAERT--
KHS2_Mmus       LDKVNNPDHS--T-Y-----HDFDDDDP----EPL----VAVPHRIPSTSRNVREEKT--
KHS1_Mmus       LDKVSNPDNHA-P-Y-----SEGDEDDL----EPH----AIIRHTIRSTNRNSRAERT--
HPK1_Mmus       LDKMKNPGKGLP--------VDIEDEEP----EPP----PAIPRRIRSTYRASSLGIP--
GCK_Mmus        LDKASDPHLG--T-L------SPEDSEL----ETH----DMFPDTIHSRSHHGPAERT--
CG7097_Dmel     LQKYQSPNPQFY--------YYL-DGDE----ESV----AGVPQRIASKMTSRTNGVPAQ
ZC404.9_Cele    LDKVNGAPTDVYD-RMSKTVDDLTEEESDMDDAPSLLTPDAAPIRIGLPAH---------
KHS_Spur        LEKARNVNPGYSP-I-----EDDDDDRL----DEQAL--VNVKKRV-SSKRTDQKDRP--
AqueK230_Aque   IRVLEAPSPKPKMSA-----SDPDEEDD----TGARK--ESQMKRISSVKHHNKIDRQ--
AqueK231_Aque   MKAFEASST-AS--A-----P-PDDQSD----FEL----GQPRKRIASIARKKTAGQA--
                :                       :                    :

KHS2_Hsap       ------------------------RSEITFGQ-----VKFD--PPLR-------------
KHS1_Hsap       ------------------------ASEINFDK-----LQFE--PPLR-------------
HPK1_Hsap       ------------------------DADCCRRH-----MEFR--KLRG-------------
GCK_Hsap        ------------------------PSEIQFHQ-----VKFG--APRR-------------
KHS2_Mmus       ------------------------RSEINFGQ-----VKFD--PPLR-------------
KHS1_Mmus       ------------------------ASEINFDK-----LQFE--PPLR-------------
HPK1_Mmus       ------------------------DADCCRRQ-----MEFQ--RPRC-------------
GCK_Mmus        ------------------------PSEIQFHQ-----VKFG--APRR-------------
CG7097_Dmel     NHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSC
ZC404.9_Cele    -----------------------------LNG-----LRL--------D-----------
KHS_Spur        ------------------------ASEINMDF-----VKKV--K--E-------------
AqueK230_Aque   ------------------------ISDVAMHG-----LNL---PPKQ-------------
AqueK231_Aque   ------------------------STLATWLE-----VV---------------------
                                                     :

KHS2_Hsap       ------------------------------------------------------------
KHS1_Hsap       ------------------------------------------------------------
HPK1_Hsap       ------------------------------------------------------------
GCK_Hsap        ------------------------------------------------------------
KHS2_Mmus       ------------------------------------------------------------
KHS1_Mmus       ------------------------------------------------------------
HPK1_Mmus       ------------------------------------------------------------
GCK_Mmus        ------------------------------------------------------------
CG7097_Dmel     SSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQH
ZC404.9_Cele    ------------------------------------------------------------
KHS_Spur        ------------------------------------------------------------
AqueK230_Aque   ------------------------------------------------------------
AqueK231_Aque   ------------------------------------------------------------


KHS2_Hsap       --------KETEPHHELPDS-DGF-LDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANK
KHS1_Hsap       --------KETEARDEMGLSSDPN-FMLQ-------------------------------
HPK1_Hsap       --------METRPPANTARLQPPR-DLR----S---------------------------
GCK_Hsap        --------KETDPLNEPWEE-EWT-LLGKEELS--------------------------G
KHS2_Mmus       --------KETEPHHELPDS-DGF-FDSSEEIYYTARSNLDLQLEYGQGHQSHCFLGGNK
KHS1_Mmus       --------KETEARDEMGLSSEPN-FILH-------------------------------
HPK1_Mmus       --------VDCRPQAETVRLYPPA-HFG----S---------------------------
GCK_Mmus        --------KETDPLNEPWEE-EWT-LLGKEELS--------------------------G
CG7097_Dmel     QSHQLPQQQQQQSHQAAQQE-HHHHHPMTSSISS-------------------------G
ZC404.9_Cele    ----------ARCLEQ--------------------------------------------
KHS_Spur        --------VPRMPPDDDGMLGEGN-YQGAHEW-----TPSNA------------------
AqueK230_Aque   --------EAQEPISAWLDE-PFH-KPRIQRLS---------------------------
AqueK231_Aque   ------------------------------------------------------------


KHS2_Hsap       SLLKSVEEEL-HQRGH---V---------------------------AHLE-DDEGDDDE
KHS1_Hsap       --------------------------------------------------W-NPFVDGAN
HPK1_Hsap       ---------------S-SPR---------------------------KQLSESSDDDYDD
GCK_Hsap        SLLQSVQEAL-EERSL-TIR---------------------------SASE-FQELDS--
KHS2_Mmus       SLLKSVEEEL-HQRGH---V---------------------------AHLE-DDEGDDDD
KHS1_Mmus       --------------------------------------------------W-NPFVDGAN
HPK1_Mmus       ---------------T-SPR---------------------------SQLSD-SDDDYDD
GCK_Mmus        SLLQSVQEAL-EERSL-TIR---------------------------PALE-LQELDS--
CG7097_Dmel     -LVTANANNISSSASL-ASMPGLSAYLGMRSHVVGHMGMGFGMGLGMSNLR-TTSIDADD
ZC404.9_Cele    -------------------------------------------------LSS-SPNTSSE
KHS_Spur        -------ETE-GRKGH-Q-T---------------------------NDFK-GAEENTEE
AqueK230_Aque   ------AEAI-TQYDMTDPE---------------------------YQSVDSIYQSPED
AqueK231_Aque   -------------------------------------------------------AESN-


KHS2_Hsap       SKHST----LKAKIPPPLPPK---------------------------------------
KHS1_Hsap       TGKST----SKRAIPPPLPPK---------------------------------------
HPK1_Hsap       VDIPT----PAEDTPPPLPPK---------------------------------------
GCK_Hsap        ------------------------------------------------------------
KHS2_Mmus       SKHST----MKAKVPPPLPPK---------------------------------------
KHS1_Mmus       TGRST----SKRAIPPPLPPK---------------------------------------
HPK1_Mmus       VDIPA----PSENIPPPLPPK---------------------------------------
GCK_Mmus        ------------------------------------------------------------
CG7097_Dmel     DELVA-ADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSSNYRSAAAAQASQAAH
ZC404.9_Cele    SD---------RRTPT-ATPR---------------------------------------
KHS_Spur        GKHDT-L--PHSDRPPPLPPK---------------------------------------
AqueK230_Aque   SLTPPPA--DRTPVAPPVPPR---------------------------------------
AqueK231_Aque   ------------------------------------------------------------


KHS2_Hsap       PK-SIFIP-QEMH-----------------------------------------------
KHS1_Hsap       PR-ISSYP-EDNF-----------------------------------------------
HPK1_Hsap       PK-FRS-P-SDEG-----------------------------------------------
GCK_Hsap        ------------------------------------------------------------
KHS2_Mmus       PK-SIFIP-QDTH-----------------------------------------------
KHS1_Mmus       PR-VNTYP-EDSL-----------------------------------------------
HPK1_Mmus       PK-FRS-P-SDDG-----------------------------------------------
GCK_Mmus        ------------------------------------------------------------
CG7097_Dmel     PH-VNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGNGGGSSNISS
ZC404.9_Cele    SLNRGYHS-ERTL----PA-----------------------------------------
KHS_Spur        QK-SVKFS-ASNG-----------------------------------------------
AqueK230_Aque   GT-SSS-R-ISRV-----------------------------------------------
AqueK231_Aque   ------------------------------------------------------------


KHS2_Hsap       --------------------------ST---EDEN--QGTIKRCPMSGSPA-KPSQ-VPP
KHS1_Hsap       --------------------------P----DEEK--ASTIKHCPDSESR--APQI-LRR
HPK1_Hsap       --------------------------PGSMGDDGQLSPGVLVRCASGPP----PNS-PRP
GCK_Hsap        ---------------------------P---DD-T--MGTIKRAPFLGPLPTDPPA-EEP
KHS2_Mmus       --------------------------SA---EDGN--QGTIKRCPSSGSPA-KPSH-VPP
KHS1_Mmus       --------------------------P----DEEK--SSTIKRCPDLEAR--APQV-LRR
HPK1_Mmus       --------------------------SGGIRDDGQLSPGVLVRCASGPP----PRT-PRP
GCK_Mmus        ---------------------------P---DD-A--IGTIKRAPFLGLPHTESTSGDNA
CG7097_Dmel     SGGASSGTNGLLDKHELDALPQAATKSA---GDGF--SHSNSPTANSGAGA-TGSR-DND
ZC404.9_Cele    -----------------KEMP-------LLPDVVG--GDALLHCGNGVIHDDDETL-RAP
KHS_Spur        --------------------------TA----S-N--ASTRESA--------PPSV-PPS
AqueK230_Aque   --------------------------PIPLPDDN-NSPHVYGNVGPSNP-----------
AqueK231_Aque   ----------------------------------------------------DRKG-IKP


KHS2_Hsap       -RPPPP---------------RLPPHKPV-------------------------------
KHS1_Hsap       -QSSPS---------------CGPVAETS-------------------------------
HPK1_Hsap       -GPPPS---------------TSSPHLT--------------------------------
GCK_Hsap        LSSPPG---------------TLPPPPS--------------------------------
KHS2_Mmus       -RPPPP---------------RLPPQKPA-------------------------------
KHS1_Mmus       -QSSPS---------------CVPVAETS-------------------------------
HPK1_Mmus       -GPPPA---------------TCSPHLT--------------------------------
GCK_Mmus        QSCSPG---------------TLSAPPA--------------------------------
CG7097_Dmel     -GPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIG
ZC404.9_Cele    -RAPPR---------------TLRAAQKA-------------------------------
KHS_Spur        -KPNR------------------PQ---Q-------------------------------
AqueK230_Aque   ------------------------------------------------------------
AqueK231_Aque   TTSPPC---------------TSPVDTTL-------------------------------


KHS2_Hsap       ------------ALGNGMSS---FQLNGER-DG-SLCQQQNEHRGTNLSRK----EKKDV
KHS1_Hsap       ------------SIGNGDGI---SKLMSENTEG-SAQ------APQLPRKK----DKRDF
HPK1_Hsap       ----------------AHSE---PSLWNPPSRE-LDK------PPLLPPKKEKM------
GCK_Hsap        --------------------------------G-PNS------SPLLPTAWATMKQREDP
KHS2_Mmus       ------------VLGNGVNS---FQLNGER-DG-SLYQQQSEQRGTNLSRK----EKKDV
KHS1_Mmus       -----------SSIGNGDGI---SKLISENTEG-SAQ------APQLPRKK----DKRDF
HPK1_Mmus       ----------------ARSD---PSLWNPAAPE-PGQ------PPLVPPRKEKMRGKMEN
GCK_Mmus        --------------------------------G-PGS------PALLPTAWATLKQQEDR
CG7097_Dmel     LLENMGKSPRTRSLSDGGTQ-DDDEAEKEAQPDLLNN------TPPVPPKRS-HKRRHTP
ZC404.9_Cele    ------------AAGNSKNRFSSTSIA----------ST----------------PSEDG
KHS_Spur        -----------QKMMNGRAP---T-TEGENTEDIDNK------PPIVPPRRIRNEFLEPP
AqueK230_Aque   --------------------------------------------PVPPRNRP-PQETVTP
AqueK231_Aque   -----------RSIANGGVA-----------------NGGV-------------------


KHS2_Hsap       PKPISNGLPPTP----------KVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFG
KHS1_Hsap       PKPAINGLPPTP----------KVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFG
HPK1_Hsap       ----------------------KRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLG
GCK_Hsap        ERSSCHGLPPTP----------KVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVG
KHS2_Mmus       PKPISNGLPPTP----------KVHMGACFSKVFNGCPLKIHCATSWINPDTRDQYLIFG
KHS1_Mmus       PKPTINGLPPTP----------KVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFG
HPK1_Mmus       ----------EK----------RREKYPLLVKLFNGCPLQIHSTAAWTHPSTKDQNLLLG
GCK_Mmus        ERSSCHGLPPTP----------KVHMGACFSKVFNGCPLQIHAAVTWVHPVTRDQFLVVG
CG7097_Dmel     PRPISNGLPPTP----------KVHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLIG
ZC404.9_Cele    -LTTFFGMPLIP----------KVPMGACFSKVMDRTELKINCAASWVHPLTGAHLLLFG
KHS_Spur        PQQASNGLPPTP----------KVTMGACFSKVFNECPLVIHCSASWVHPETRDQYIIFG
AqueK230_Aque   TNPTPPAVPPRPSSKPSIHKKQSTEGRAYFSKIFNGCPLKLHCATSWTHPHNQNYYVLLG
AqueK231_Aque   ----------------------EERGRACFTKIFKGCPLQVHCAGSWIHPIREVLFVLLG
                                           . : *::.   * ::.: :* :*      ::.*

KHS2_Hsap       AEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSIS-GKASQLYSHNLPGLFDYAR
KHS1_Hsap       TEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAK
HPK1_Hsap       AEEGIFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLS-GKTPHLYSHSILGLLERKE
GCK_Hsap        AEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLS-GKSTHIWAHDLPGLFEQRR
KHS2_Mmus       AEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSVS-GKASQLYSHNLPGLFDYAR
KHS1_Mmus       TEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEQAK
HPK1_Mmus       AEEGIFILNRND-QEATLEMIFPGRTTWLYCINNLLMSLS-GKTPYLYSHSILGLLERKD
GCK_Mmus        AEEGIYTLNLHELHEDTMEKLISQRCSWLYCVNNVLLSLS-GKSTHIWAHDLPGLFEQRR
CG7097_Dmel     AEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMSLS-GKSCQLYRHDLVALHSKQT
ZC404.9_Cele    TEQGIYSFDTNCMPDGNLSKIHHRRCSWMFVYADRLTAIQ-GNTPYVYRHDLVALTQKNL
KHS_Spur        CDEGIYMFNLTQIHEGAMDQMFPRKTTWLYIINNIMMSLS-GKNPSIYQHNLVALVDKNP
AqueK230_Aque   AEEGLFSLQANTQQDPVMEQVSPRSCHWLRVVENVLIWLS-GTNHMISMTNLIQLFQSES
AqueK231_Aque   TQEGLFYLQVNREGDPIIEQVDSDH---MISM-----------------TNLILLFQNEQ
                 ::*:: ::     :  :. :       :                     .:  * .

KHS2_Hsap       QMQKLPV--AIPAHKLPDR-ILPRKFSVSAKIPETKWCQKCCVVRNP--YTGHKYLCGAL
KHS1_Hsap       K-PGLAA--HIQTHRFPDR-ILPRKFALTTKIPDTKGCHKCCIVRNP--YTGHKYLCGAL
HPK1_Hsap       TRAGNP-----IAHISPHR-LLARKNMVSTKIQDTKGCRACCVAEGA--SSGGPFLCGAL
GCK_Hsap        LQQQVPL--SIPTNRLTQR-IIPRRFALSTKIPDTKGCLQCRVVRNP--YTGATFLLAAL
KHS2_Mmus       QMQKLPV--AIPAHKLPDR-ILPRKFAVSAKIPETKWCQKCCVVRNP--YTGHKYLCGAL
KHS1_Mmus       K-PGLAA--HIQTHRFPDR-ILPRKFALTTKIPDTKGCHKCCIVRNP--YTGHKYLCGAL
HPK1_Mmus       GRTGSP-----IAHISPHR-LLARKNMVSSKIQDTKGCRACCVAESA--SSGGPFLCGAL
GCK_Mmus        LQHQAPL--SIPTNRITQR-IIPRRFALSTKIPDTKGCLQCRVVRNP--YTGSTFLLAAL
CG7097_Dmel     V----RF--SLHMNKIPER-LVPRKFALTTKVPDTKCCTQCCVTRNP--YNGYKYLCGAT
ZC404.9_Cele    T---LKM--SKNLNKIPEK-YVPKRLAITVRMPETRGALQCTVKRGQGAQANSLFLCCAV
KHS_Spur        HRFHMPSRFGEKLQRIPDK-LVPRKFALSHKVPDTKGCTKCCVVRNP--YNSHKYLCGAL
AqueK230_Aque   QKA--PG---------------HRNRSHTSKIHDSKGCYKCSIARNP--FSDQRYLLAAV
AqueK231_Aque   EIAARRG--GGGGGKDGETFRRNRRIRHSSKIKDSIGCFKCSIVVNP--YNKEKYLIAAV
                                       :.   : :: ::  .  * :  .        :*  *

KHS2_Hsap       QTSIVLLEWVEPMQKFMLIKHI--DFPIPC------------PLRMFEMLVV-PEQEYPL
KHS1_Hsap       QSGIVLLQWYEPMQKFMLIKHF--DFPLPS------------PLNVFEMLVI-PEQEYPM
HPK1_Hsap       ETSVVLLQWYQPMNKFLLVRQV--LFPLPT------------PLSVFALLTG-PGSELPA
GCK_Hsap        PTSLLLLQWYEPLQKFLLLKNF--SSPLPS------------PAGMLEPLVL-DGKELPQ
KHS2_Mmus       QTSIVLLEWVEPMQKFMLIKHI--EFPMPC------------PLRMFEMLVV-PEQEYPL
KHS1_Mmus       QSGIVLLQWYEPMQKFMLIKHF--DFPLPS------------PLNVFEMLVI-PEQEYPM
HPK1_Mmus       ETSVVLLQWYQPMNKFLLVRQV--LFPLPT------------PLPVFTLLTT-PGSELPA
GCK_Mmus        PASLLLLQWYEPLQKFLLLKNF--SSPLPS------------PAGMLEPLVL-DGKELPQ
CG7097_Dmel     PSGIFLMQWYDPLNKFMLLKQC--EWPAISIQGGGHGCVQNGHTPVFEMIIT-PELEYPI
ZC404.9_Cele    RKTVHLFQWYNPMNQFVLVRSEPIREDIRF------------PIRPFALINS-RTSDFPE
KHS_Spur        PAGVVLLQWYEPMNKFLQVKVF--DCPLPP------------EIKVFEMLIK-PDAEFPI
AqueK230_Aque   PKGILVMQWYQPRHAFMHVKLF--ECSLPS------------PLNMFEAFVI-ENDEYPS
AqueK231_Aque   PKGILLMQWYQISHAFMLVKLF--ECSLPS------------PLVLFEAFVLTQEDEYPT
                   : :::* :  : *: ::                          :  :      : *

KHS2_Hsap       VCVGVSRGRDFNQVVRFETVNPNSTSSWFTES------------DTPQTNVTHVTQLERD
KHS1_Hsap       VCVAISKGTESNQVVQFETINLNSASSWFTEIG----------AGSQQLDSIHVTQLERD
HPK1_Hsap       VCIGVSPGRPGK-SVLFHTVRFGALSCWLGEM------------STEHRGPVQVTQVEED
GCK_Hsap        VCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIP----------PEGIPGSAQQVIQVDRD
KHS2_Mmus       VCVGVSRGRDFNQVVRFETVNPNSTSSWFTES------------DAPQTSVTHVTQLERD
KHS1_Mmus       VCVAISKGSDSSQVVQFETINLNSASSWFTEIG----------AGSQQLDSIHVTQLERD
HPK1_Mmus       VCIGVSPGQAAK-SVLFHTVRFGALSCWLDDS------------STEHKGPVQVIQVKED
GCK_Mmus        VCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIP----------PEGIPGSAQQVIQVDRD
CG7097_Dmel     VCTGVRKAMN-G-CLKLELINMNSAS-WFHSEDLEYDAMATMVPRRDLLKVVRVHQVEKD
ZC404.9_Cele    LCIGVGQMSGSN-EYQFNMINFCSSTNN-SELSGDLNSSYGSLADDEMLEVGSMHQIDRD
KHS_Spur        VCVGVARGLDRS-HLTFDVVNLNSTSSWFVEHP----------PTEKLLDVVCVSQIERD
AqueK230_Aque   VCVGVRESEG-G-NVQFNAININSNSCWFDSF------------S--NDEIIELQQLEKD
AqueK231_Aque   ICVGVNTSTG-D-NVLFNTISLNPSSSSITV--------------SHNSDITKLEQVEKD
                :* .            :. :   .                             : *:..*

KHS2_Hsap       TILVCLD----CCIKIVNLQGRLKS-SRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG
KHS1_Hsap       TVLVCLD----KFVKIVNLQGKLKS-SKKLASELSFDFRIESVVCLQDSVLAFWKHGMQG
HPK1_Hsap       MVMVLMD----GSVKLVTPEGSPVR-GL-RTPEIPMTEAVEAVAMVGGQLQAFWKHGVQV
GCK_Hsap        TILVSFE----RCVRIVNMQGEPT---ATLAPELTFDFPIETVVCLQDSVLAFWSHGMQG
KHS2_Mmus       TILVCLD----CCIKIVNLQGRLKS-SRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG
KHS1_Mmus       TVLVCLD----KFVKIVNLQGKLKS-SKKLASELSFDFRIESVVCLQDSVLAFWKHGMQG
HPK1_Mmus       MVMVLMD----GSLKLVTPEGAPAP-GL-RTPEIPMTEAVEAVAMVEDRLEAFWKHGVQV
GCK_Mmus        TVLVSFE----RCVRIVNLQGEPT---AALAPELTFDFTIETVVCLQDSVLAFWSHGMQG
CG7097_Dmel     AILVCYG----NLIQVVTLQGNPKQ-HKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQG
ZC404.9_Cele    TLCFSFR----NKVVLTDLQGFERP-K---PSIFTFNFHIEYLHVVDGTILAFHANGVQG
KHS_Spur        TVLVCFD----SEVKVVNLNGRPRN-SKKLLTELHFDFAVDKLVVLQDSVLAFHRHGMQG
AqueK230_Aque   TIFVASQ----FCAKFVDLNGTMKP-SGKQASQIYFDKKTESMVYLQNCVLSFHKHGMQG
AqueK231_Aque   TILILDSRILTYCAKFVDISGSLKAPEEKMASSLYFDK--ESVM-----MGSFNDHGLQG
                 : .           ..  .*          . : :    : :      : :*  :*:*

KHS2_Hsap       RSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPT-------------ANSNLYIL
KHS1_Hsap       KSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPT-------------AHSNLYIL
HPK1_Hsap       WALGSDQLLQELRDPTLTFRLLGSPRL---ECSGTISPHCNLLLPGSSNSPASASRVAG-
GCK_Hsap        RSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPE-------------AHSNLYIL
KHS2_Mmus       RSFRSNEVTQEISDNTRIFRLLGSDRVVVLESRPTDNPT-------------ANSNLYIL
KHS1_Mmus       KSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPA-------------AHSNLYIL
HPK1_Mmus       WAPGLKQPLQELRDPTLTFRLLCSPRPVVVETRPTDDP-------------TAPSNLYI-
GCK_Mmus        RSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPG-------------AHSNLYIL
CG7097_Dmel     KSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGS---------LGSEEGHDLYIL
ZC404.9_Cele    RDLKSNLNTQDLCDVSRLYRVIGDDRVIILRSQPMSPR-----------NSGDTCDVSLL
KHS_Spur        RSFRSNEVTQEICDKSKLFTLLGHEKLTVLKSHPLSDPT-------------APCNIYLL
AqueK230_Aque   KSLITQQVTAEVADSSKVFHLLGSHGTIIIETKQADDAS-------------GPSNLYIL
AqueK231_Aque   KSLLTEQVTAEVIDHSKKFKLLCSDGTIIVETKRADNPS-------------YPSSLYLL
                          :: * :  : ::        .                         :

KHS2_Hsap       AG----HEN---SY
KHS1_Hsap       AG----HEN---SY
HPK1_Hsap       -------IT---GL
GCK_Hsap        TG----HQS---TY
KHS2_Mmus       AG----HEN---SY
KHS1_Mmus       AG----HEN---SY
HPK1_Mmus       ------------QE
GCK_Mmus        TG----HQS---SY
CG7097_Dmel     AG----HEA---SY
ZC404.9_Cele    MG----HTDTPIAG
KHS_Spur        TG----HAN---MM
AqueK230_Aque   VSEEAYHVH---SQ
AqueK231_Aque   ES----E-E---AT