PDHK4_Hsap M------------KAARFVLRSAG-----------------------SL----NGAGLVP
PDHK1_Hsap M------------RLARLLRGAAL-AGPGPGLRAAGFSRSFSSDSGSSP----ASERGVP
PDHK2_Hsap M------------RWVWALLKNA------------------------S-------LAGAP
PDHK3_Hsap M------------RLFRWLLK-----------------------------------QPVP
aSWK467_Cele M------------RFSRKLLGPF--------------------------------VGSLA
PDHK_Spur MV-----------RLTVRLLAM--------------------------------AKKNMQ
PDHK1_Mmus M------------RLARLLRGGTS-VRPLCAVPCASRSLASASASGSGP----ASELGVP
PDHK2_Mmus M------------RWVRALLKNA------------------------S-------LAGAP
PDHK3_Mmus M------------RLFYRLLK-----------------------------------QPVP
PDHK4_Mmus M------------KAARFVMRSAS-----------------------SL----SSASLVP
pdhk-2_Cele M------------RFSRKLLGPF--------------------------------VGSLA
PDK_Dmel M------------RLFPVRFSAA------------------------SL-----SMASLA
YIL042C_Scer MWKIMRSWKCGGMRWAHRQRPSHELLS-------------QL-----SFDQHYKIRSNIE
CC1G_15212_Ccin M------------SAGFRI-T-----------------------------------PALW
*
PDHK4_Hsap REVEHFSRYSPSPLSMKQLLDFGSENAC--ERTSFAFLRQELPVRLAN---ILKEIDILP
PDHK1_Hsap GQVDFYARFSPSPLSMKQFLDFGSVNAC--EKTSFMFLRQELPVRLAN---IMKEISLLP
PDHK2_Hsap KYIEHFSKFSPSPLSMKQFLDFGSSNAC--EKTSFTFLRQELPVRLAN---IMKEINLLP
PDHK3_Hsap KQIERYSRFSPSPLSIKQFLDFGRDNAC--EKTSYMFLRKELPVRLAN---TMREVNLLP
aSWK467_Cele KKLDYYSQFQPSSLTIQQYLDFGRIG-T-S-ANSYTFLKNELLVRLAN---IMQEFTLLP
PDHK_Spur AQMEYYSKFSPSPLSIKQFMDFGQSKDV-DSAKSFVFLRQELPVRIAN---IMKEINLLP
PDHK1_Mmus GQVDFYARFSPSPLSMKQFLDFGSVNAC--EKTSFMFLRQELPVRLAN---IMKEISLLP
PDHK2_Mmus KYIEHFSKFSPSPLSMKQFLDFGSSNAC--EKTSFTFLRQELPVRLAN---IMKEINLLP
PDHK3_Mmus KQIERYSRFSPSPLSIKQFLDFGRDNAC--EKTSYMFLRKELPVRLAN---TMREVNLLP
PDHK4_Mmus REVELFSRYSPSPLSMKQLLDFGSENAC--ERTSFAFLRQELPVRLAN---ILKEIDILP
pdhk-2_Cele KKLDYYSQFQPSSLTIQQYLDFGRIG-T-S-ANSYTFLKNELLVRLAN---IMQEFTLLP
PDK_Dmel KMLDFYSGFNPSPLSIKQFMDFGQ-NAC--EKKSYIFLRKELPVRLAN---IMKEIALLP
YIL042C_Scer LLIQDYASKPIAPLNYEYFLQYRP-PLT--KKEEYMLTIKTINLLLSLTCKRLNAIQRLP
CC1G_15212_Ccin DKIHHFASFPQTGVSLQQMVLFGQNPSQGTLLKASQFLSEELPVRLAH---RVKELDELP
:. :: : :. : : : : : : : :: :. . **
PDHK4_Hsap TQLVNTSSVQLVKSWYIQSLMDLVEFHEKS------------------------------
PDHK1_Hsap DNLLRTPSVQLVQSWYIQSLQELLDFKDKS------------------------------
PDHK2_Hsap DRVLSTPSVQLVQSWYVQSLLDIMEFLDKD------------------------------
PDHK3_Hsap DNLLNRPSVGLVQSWYMQSFLELLEYENKS------------------------------
aSWK467_Cele PKLLQMPSSKMVSNWYAESFEDLLLFEAS-------------------------------
PDHK_Spur EKLLQMPSVRMVQGWYQQTFEELLEYVEKT------------------------------
PDHK1_Mmus DNLLRTPSVQLVQSWYIQSLQELLDFKDKS------------------------------
PDHK2_Mmus DRVLGTPSVQLVQSWYVQSLLDIMEFLDKD------------------------------
PDHK3_Mmus DNLLNRPSVGLVQSWYMQSFLELLEYENKS------------------------------
PDHK4_Mmus DRLVNTPSVQLVKSWYIQSLMDLVEFHEKS------------------------------
pdhk-2_Cele PKLLQMPSSKMVSNWYAESFEDLLLFEAS-------------------------------
PDK_Dmel DNLLHTRSVSEVSSWYVKSFEDVLVYEKA-------------------------------
YIL042C_Scer YNAVINPHIERTNSLYLKSLQTLLSIAYPYEL----------------------------
CC1G_15212_Ccin HNLSDMPSIKRVKNWYAQSFEELINFPHPQLPPEIRQALITSRSDELALPESKPNPSLID
. ... * ::: ::
PDHK4_Hsap ------------------------------------------PDDQKALSDFVDTLIKVR
PDHK1_Hsap ------------------------------------------AEDAKAIYDFTDTVIRIR
PDHK2_Hsap ------------------------------------------PEDHRTLSQFTDALVTIR
PDHK3_Hsap ------------------------------------------PEDPQVLDNFLQVLIKVR
aSWK467_Cele ------------------------------------------DSSPEQVARFNDQLTVVL
PDHK_Spur ------------------------------------------EEEDPVLLRYINQLTTIR
PDHK1_Mmus ------------------------------------------AEDAKTIYEFTDTVIRIR
PDHK2_Mmus ------------------------------------------PEDHRTLSQFTDALVTIR
PDHK3_Mmus ------------------------------------------PEDPRVLDNFLNVLINIR
PDHK4_Mmus ------------------------------------------PEDQKALSEFVDTLVKVR
pdhk-2_Cele ------------------------------------------DSSPEQVARFNDQLTVVL
PDK_Dmel ------------------------------------------EPTHDNLQKFVADLDLIR
YIL042C_Scer ------------------------------------------HNPPKIQAKF----TELL
CC1G_15212_Ccin TIYGSSPSNGNGNGGNGFNKLRLRVPMERRYYANTSNITHWPPEVQDYNKRFTKLLEHIK
: :
PDHK4_Hsap NRHHNVVPTMAQG-----------------------------------------------
PDHK1_Hsap NRHNDVIPTMAQG-----------------------------------------------
PDHK2_Hsap NRHNDVVPTMAQG-----------------------------------------------
PDHK3_Hsap NRHNDVVPTMAQG-----------------------------------------------
aSWK467_Cele KRHAHVVETMAEG-----------------------------------------------
PDHK_Spur NRHVNVVETMAQG-----------------------------------------------
PDHK1_Mmus NRHNDVIPTMAQG-----------------------------------------------
PDHK2_Mmus NRHNDVVPTMAQG-----------------------------------------------
PDHK3_Mmus NRHNDVVPTMAQG-----------------------------------------------
PDHK4_Mmus NRHHNVVPTMAQG-----------------------------------------------
pdhk-2_Cele KRHAHVVETMAEG-----------------------------------------------
PDK_Dmel NRHNDVVQTMAQG-----------------------------------------------
YIL042C_Scer DDHEDAIVVLAKG-----------------------------------------------
CC1G_15212_Ccin SRHDPTVTTVAQGRSFRLPAFFGVLGVFWASGLGSVPLPSLYSRSMDPFVICEEHALTEL
. * .: .:*:*
PDHK4_Hsap ------------------------------------------------IIEYKDACT--V
PDHK1_Hsap ------------------------------------------------VIEYKESFG--V
PDHK2_Hsap ------------------------------------------------VLEYKDTYG--D
PDHK3_Hsap ------------------------------------------------VIEYKEKFG--F
aSWK467_Cele ------------------------------------------------LIELRESDG--V
PDHK_Spur ------------------------------------------------ILEMRESYK--V
PDHK1_Mmus ------------------------------------------------VTEYKESFG--V
PDHK2_Mmus ------------------------------------------------VLEYKDTYG--D
PDHK3_Mmus ------------------------------------------------VIEYKEKFG--F
PDHK4_Mmus ------------------------------------------------ILEYKDTCT--V
pdhk-2_Cele ------------------------------------------------LIELRESDG--V
PDK_Dmel ------------------------------------------------VIEMKENEGGQV
YIL042C_Scer ------------------------------------------------LQEIQSCYP---
CC1G_15212_Ccin SIPFTLPQCLHAPLLGFLSLSLTHALASRLPPTFLVTGPRLPRTDLLCVLEWKRSQN--A
: * :
PDHK4_Hsap DPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSD-S--QTGNPSHIGSI----------
PDHK1_Hsap DPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSI----------
PDHK2_Hsap DPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST--NPAHPKHIGSI----------
PDHK3_Hsap DPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDT--NPVHPKHIGSI----------
aSWK467_Cele DIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGN-V--LPESPRHVGCI----------
PDHK_Spur DQHEENNVQYFLDRFYISRISIRMLINQHTLMFGQ-I--PTTHPLLVGSI----------
PDHK1_Mmus DPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG--SPSHRKHIGSI----------
PDHK2_Mmus DPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST--NPAHPKHIGSI----------
PDHK3_Mmus DPFISSNIQYFLDRFYTNRISFRMLINQHTLLFGGDT--NPAHPKHIGSI----------
PDHK4_Mmus DPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSD-S--KTGNPSHIGSI----------
pdhk-2_Cele DIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGN-V--LPESPRHVGCI----------
PDK_Dmel DAPTESSIQYFLDRLYMSRISIRMLINQHTLLFGG-N--PHAGGRHIGCL----------
YIL042C_Scer ----KFQISQFLNFHLKERITMKLLVTHYLSLMAQNK--GDTNKRMIGIL----------
CC1G_15212_Ccin RH-IGLDIQAWLDRFYMSRIGIRFLIGQHVALN---T--QQAHEDYVGIICTKAVRVPPS
:. :*: .** ::* :: : :* :
PDHK4_Hsap ------------------------------------------------------------
PDHK1_Hsap ------------------------------------------------------------
PDHK2_Hsap ------------------------------------------------------------
PDHK3_Hsap ------------------------------------------------------------
aSWK467_Cele ------------------------------------------------------------
PDHK_Spur ------------------------------------------------------------
PDHK1_Mmus ------------------------------------------------------------
PDHK2_Mmus ------------------------------------------------------------
PDHK3_Mmus ------------------------------------------------------------
PDHK4_Mmus ------------------------------------------------------------
pdhk-2_Cele ------------------------------------------------------------
PDK_Dmel ------------------------------------------------------------
YIL042C_Scer ------------------------------------------------------------
CC1G_15212_Ccin PSPFDTLFHFFGTSSAIEPHTDETAFLFLFRMRLVVVVVDVIVMDTLVVVMRSRYLDSTR
PDHK4_Hsap -------------------------------DPNCDVVAVVQDAFECSRMLCDQYYLSSP
PDHK1_Hsap -------------------------------NPNCNVLEVIKDGYENARRLCDLYYINSP
PDHK2_Hsap -------------------------------DPNCNVSEVVKDAYDMAKLLCDKYYMASP
PDHK3_Hsap -------------------------------DPTCNVADVVKDAYETAKMLCEQYYLVAP
aSWK467_Cele -------------------------------DPACDVESVVYDAFENARFLCDRYYLTSP
PDHK_Spur -------------------------------DPSCDIVAVIRDAYDSAKYLCDQYYLASP
PDHK1_Mmus -------------------------------NPNCDVVEVIKDGYENARRLCDLYYVNSP
PDHK2_Mmus -------------------------------DPNCSVSDVVKDAYDMAKLLCDKYYMASP
PDHK3_Mmus -------------------------------DPTCNVADVVKDAYETAKMLCEQYYLVAP
PDHK4_Mmus -------------------------------DPNCDVVAVVQDAFECAKMLCDQYYLTSP
pdhk-2_Cele -------------------------------DPACDVESVVYDAFENARFLCDRYYLTSP
PDK_Dmel -------------------------------DPACDLSDVVRDAYENARFLCDQYYLTSP
YIL042C_Scer -------------------------------HRDLPIAQLIKHVSDYVNDICFVKFNTQR
CC1G_15212_Ccin LGRCDVFGIWFCLDLGGYGAISRTFYTCAVISGLWNVHDIVQEAIENARFVCEEHYAMFK
: :: . : . :* :
PDHK4_Hsap ELKLTQVNGKFP-DQPIHIVYVPSHLHHMLFELFKNAMRATVEHQEN-Q-PSLTPIEVIV
PDHK1_Hsap ELELEELNAKSP-GQPIQVVYVPSHLYHMVFELFKNAMRATMEHHAN-R-GVYPPIQVHV
PDHK2_Hsap DLEIQEINAANS-KQPIHMVYVPSHLYHMLFELFKNAMRATVESHES-S-LILPPIKVMV
PDHK3_Hsap ELEVEEFNAKAP-DKPIQVVYVPSHLFHMLFELFKNSMRATVELYED-RKEGYPAVKTLV
aSWK467_Cele SMKLEMHNAVEK-GKPISIVAVPSHLYHMMFELFKNAMRATVEYHGV-D-DDLPDIKVYV
PDHK_Spur DIDVRWIDARDG-SDSIRMVYVPSHLYHIMFELLKNAMRAVMEHKGP-SASEFPPIGILV
PDHK1_Mmus ELELEELNAKSP-GQTIQVVYVPSHLYHMVFELFKNAMRATMEHHAD-K-GVYPPIQVHV
PDHK2_Mmus DLEIQEVNATNA-NQPIHMVYVPSHLYHMLFELFKNAMRATVESHES-S-LTLPPIKIMV
PDHK3_Mmus ELEVEEFNAKAP-NKPIQVVYVPSHLFHMLFELFKNSMRATVELHED-KKEGYPAVKTLV
PDHK4_Mmus ELNLTQVNGKFP-GQPIHIVYVPSHLHHMLFELFKNAMRATVEHQEN-R-PSLTPVEATV
pdhk-2_Cele SMKLEMHNAVEK-GKPISIVAVPSHLYHMMFELFKNAMRATVEYHGV-D-DDLPDIKVYV
PDK_Dmel ALEIQQHSSEPGDNLPIRTVYVPSHLYYMLFELFKNSMRAVVEHHGHDNNDTLPPLKVAI
YIL042C_Scer ----TPVLIHPP-SQDITFTCIPPILEYIMTEVFKNAFEAQIALG----KEH-MPIEINL
CC1G_15212_Ccin GPPVQLICP---P--SLTFAYVPGHLSHICFELLKNSLRAVVERYGVDAEDHFPPIKVIV
: . :* * :: *::**::.* : : :
PDHK4_Hsap VL-GKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPV-MDN-------SRNAPLAGFG
PDHK1_Hsap TL-GNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPR-VET-------SRAVPLAGFG
PDHK2_Hsap AL-GEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQ-PG--------TGGTPLAGFG
PDHK3_Hsap TL-GKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPS-LEP-------TRAAPLAGFG
aSWK467_Cele VK-GQEDLSIKICDRGGGVSRTILERLYNYMYSTAPPPP-RDG-------T-QAPLAGYG
PDHK_Spur TK-GKEDVTIKVSDEGGGIPKSEIDLLFNYMYSTAPAPP-KPG------VSIIPPLAGYG
PDHK1_Mmus TL-GEEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPR-VET-------SRAVPLAGFG
PDHK2_Mmus AL-GEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQ-PG--------TGGTPLAGFG
PDHK3_Mmus TL-GKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPS-LEP-------TRAAPLAGFG
PDHK4_Mmus VL-GKEDLTIKISDRGGGVPLRITDRLFSYTYSTAPTPV-MDN-------SRNAPLAGFG
pdhk-2_Cele VK-GQEDLSIKICDRGGGVSRTILERLYNYMYSTAPPPP-RDG-------T-QAPLAGYG
PDK_Dmel CK-GKEDICVKISDQGGGIPRSQTDQLFKYMYSTAPQPS-KSD-------LHTVPLAGYG
YIL042C_Scer LKPDDDELYLRIRDHGGGITPEVEALMFNYSYSTHTQQS-ADSESTDLPGEQINNVSGMG
CC1G_15212_Ccin VE-GKEDITIKISDEGGGIARSAIPLIWTYMYTTMEHQTSLDEDF--QASDFKAPMAGFG
..::: ::: * ***:. ::.* *:* ::* *
PDHK4_Hsap YGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSE
PDHK1_Hsap YGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHE
PDHK2_Hsap YGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQE
PDHK3_Hsap YGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPE
aSWK467_Cele YGLPLSRLYARYFLGDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQ
PDHK_Spur YGLPISRLYAKYFHGDLTLSSMDGYGTDAVVYLKVLSSEASELLPIYNSAVSRYYKTPTP
PDHK1_Mmus YGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESVERLPVYNKAAWKHYKANHE
PDHK2_Mmus YGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQE
PDHK3_Mmus YGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPE
PDHK4_Mmus YGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLKALSSESVEKLPVFNKSAFKHYQMSSE
pdhk-2_Cele YGLPLSRLYARYFLGDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQ
PDK_Dmel YGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKALSDEANELLPIFNKTSSKFYRATVP
YIL042C_Scer FGLPMCKTYLELFGGKIDVQSLLGWGTDVYIKLKGPSKTA--------------------
CC1G_15212_Ccin YGLPLSRLYARYFGGDLRLIAMDGFGTDVYIHLNRLSS-SREPL----------------
:***:.: * . * *.: : : * ***. : :: . :
PDHK4_Hsap ADDWCIPSREPKNLAKE----------VAM
PDHK1_Hsap ADDWCVPSREPKDMTTF----------RSA
PDHK2_Hsap AGDWCVPSTEPKNTSTY----------RVS
PDHK3_Hsap ADDWSNPSSEPRDASKYKAKQDKIKTNRTF
aSWK467_Cele VADWSHH--VPGQGNRP----------AQS
PDHK_Spur ASDWSTPGYFIRNYTTKR---------YGK
PDHK1_Mmus ADDWCVPSREPKDMTTF----------RSS
PDHK2_Mmus AGDWCVPSTEPKNTSTY----------RVS
PDHK3_Mmus ADDWSNPSSEPRDASKYKAKQDKIKSNRTF
PDHK4_Mmus ADDWCIPSREPKNLAKEK---------LAV
pdhk-2_Cele VADWSHH--VPGQGNRP----------AQS
PDK_Dmel TGDWSNQVKYAKKKKTSA---------VSQ
YIL042C_Scer ---------------LL----------SKK
CC1G_15212_Ccin -----------------------------P