Wee1_Hsap MSFLSRQQPPP-PRR-AG---------AACTLR---------------------QKLIFS
Wee1B_Hsap MDDKDIDKE----------------------LR---------------------QKLNFS
DDB0220004_Ddis MDFPSQSEKKKYITKKRTTLFSYDDDDDDDDFDQNREFIHMSSYEESKDQQNSFNTLLLS
wee_Dmel MAFRQSEHEMS-VTS-LD---------SSVELR---------------------S-----
Wee1a_Spur MDGSYTENPAK-Q-----------------------------------------NKMTFT
Wee1b_Spur MSLAAPMNSLF-HRG-V-----------HGSPS---------------------QRLDFG
AqueK218_Aque MCTHAVVWG---------------------------------------------------
Wee1B_Mmus MADTETDQG----------------------LN---------------------KKLSFS
Wee1_Mmus MSFLSRQQPPP-TRR-VG---------AAYSLR---------------------QKLIFS
*
Wee1_Hsap PCSDC-EEEEEE---------EEEEG-S-GHSTGEDS-----------------------
Wee1B_Hsap YCEET-EIEGQK---------KVEESREASSQTPEKG-----------------------
DDB0220004_Ddis ELSNC-EDQKQQ---------QQQQS---SSPTQSDCDSSPTNNNNNNNTNNNIVHHLNN
wee_Dmel -----------------------RSP-SPQVFNPRKL-----------------------
Wee1a_Spur CI----------------------------------------------------------
Wee1b_Spur DALGS-EGESDASFAAYSDFNEIQEG-AIDDHSPISS-----------------------
AqueK218_Aque ------------------------------------------------------------
Wee1B_Mmus FCEEDTESEGQM---------TAQDIGGAQSQKPGRE-----------------------
Wee1_Mmus PGSDC-EEEEEE----------EEEG-S-GHSTGEDS-----------------------
Wee1_Hsap -------------------------------------------AFQE--PDS-----PLP
Wee1B_Hsap -------------------------------------------EVQD--SEA-----KGT
DDB0220004_Ddis SNSIPISGSNNNNNNNNNNNNNNNNNNNNNNNSHHHHLRKGRRLFHDDNDDQ-----PIY
wee_Dmel -------------------------------------------RFADDDFDK-----DTP
Wee1a_Spur ------------------------------------------------------------
Wee1b_Spur -------------------------------------------SFSDDRDDSLNLTAEWD
AqueK218_Aque ------------------------------------------------------------
Wee1B_Mmus -------------------------------------------ESEE--LEG-----PVP
Wee1_Mmus -------------------------------------------AFQE--PDS-----PLP
Wee1_Hsap PARS----------------PTEPGPER-R--RSPGPAPGSPGELEEDLLLPGACPGAD-
Wee1B_Hsap PPWT----------PLSNVHELDTSSEKDK--ESPDQILR--------------------
DDB0220004_Ddis PASASLSSTKTNMFPSSP--ILYSSPSSQQQQQQQQQ--QSQSQQTNEFKVPSFTPLSFI
wee_Dmel EGAS----------PQ------HPLQQRPK--LSSGEEQ---------------------
Wee1a_Spur ------------------------------------------------------------
Wee1b_Spur PALA----------------TPKSSPSRRRVQRRPNSRLH---DGENS------------
AqueK218_Aque --NS----------LT------TPTSHRST--A----AM---------------------
Wee1B_Mmus PTRD----------------ELHTSLSRDK--ESPGPDLW--------------------
Wee1_Mmus SARS----------------PAEAEAERRR--RSPGAEPSSPGELEDDLLLQGGGGGAQ-
Wee1_Hsap ---------------------------------------------EA-GGGAEGDSWEEE
Wee1B_Hsap ------------------------------------------------------------
DDB0220004_Ddis NNSSTNSMNIRPINNNRIYNNLNNNNNNNNNNNNNINNINNNNINNINNNYNNNNNNEED
wee_Dmel ------------------------------------------------------------
Wee1a_Spur ------------------------------------------------------------
Wee1b_Spur ------------------------------------------------------------
AqueK218_Aque ------------------------------------------------------------
Wee1B_Mmus ------------------------------------------------------------
Wee1_Mmus ---------------------------------------------AA-GGGAEGDSWEEE
Wee1_Hsap GFGSSSPV-KSPAA----PYFLGSSFSPVRCGGPGD------------------------
Wee1B_Hsap -----TP---------VS--------HP--------------------------------
DDB0220004_Ddis QIFSSS----LPT-------------SPVSWSANGSMMNGHNINNITGNHSRFLSNGSYN
wee_Dmel Q-------LDSK---------------IGKEGGDG-------------------------
Wee1a_Spur ------------------------------------------------------------
Wee1b_Spur ---IASPHFRRPSDSSCSPSPMVCASSPASSAGGGD------------------------
AqueK218_Aque D-------YTSP---------------PSKC-IRF-------------------------
Wee1B_Mmus -----KS---------VS--------GP--------------------------------
Wee1_Mmus GFGSSSPV-KSPST----AYFLSSPFSPVRCGGPGD------------------------
Wee1_Hsap ---A-----SPRGCGARRAGEG---RRSPRPDHPGTPPH-KTFRKLRLFDTPHTPKSLLS
Wee1B_Hsap ------------------------------LKCPETPAQPDSRSKLLPSDSPSTPKTMLS
DDB0220004_Ddis KGNTFPSTEVKRVRPDQRAFNENSFSMSPT---PSPPPT-PSLKR-NNYSS---PKFEPV
wee_Dmel -------------------------------DVSMSPPC-QKVRALRLFSTPATPKTILQ
Wee1a_Spur ------------------------------------------------------------
Wee1b_Spur ---A----------------------------VGSPPPH-KRLRNLKLFDSPHTPKSLIQ
AqueK218_Aque -------------------------------NSPTNIINSTSSSKLRLFDTPHTPMTLLR
Wee1B_Mmus ------------------------------PKCPETPVL-HSKSKLPVPTNFSTPKNSLG
Wee1_Mmus ---A-----SPQGCGAPRAMDD---PCSPQPDYPSTPPH-KTFRKLRLFDTPHTPKSLLS
Wee1_Hsap KARGIDSSSVKLRGSSLFMDTEKS-------------------------------GK---
Wee1B_Hsap RLVISPTGKLPSRGPKHLKLTPAP-------------------------------LK---
DDB0220004_Ddis FIRLAEERTNRKRSTSMTSNVNNNNN---------------NNANNNNVNNNNN-NN---
wee_Dmel KSTTQCSNHLSAAAAAVNASR------R----------------SDDLFRLSERPRSLPL
Wee1a_Spur ---------------VLTL-----------------------------------------
Wee1b_Spur KANAS-ARRNKLLASRLFSEKPASSTPTDHGDGPIAFGIARPHTAPNMRNLQRR-ST---
AqueK218_Aque RSSMS-ENDLNIQSDVMMTSSVPPPNNRPGGE---------SSIRPRISRLTLS---GPP
Wee1B_Mmus QPEISLLEKLSSRSSRHMRLTPAS-------------------------------LM---
Wee1_Mmus KARVIDSGSVKLRGSSLFMDTEKS-------------------------------GK---
Wee1_Hsap REFDVRQTPQVNINPFTPDSL---LLHSSGQCRRR-KRTY--------------------
Wee1B_Hsap DE--MTSLALVNINPFTPESYKKLFLQSGGKRK---IRGD--------------------
DDB0220004_Ddis NGPNSISSLIANVNPFTEEGR---LQSLNKPCPSF-QLVNNN--NNNNNASNNNNDNNNN
wee_Dmel HNRKLPTQDTANVNPFTPDSL---MAHNKKRCRTQFGRENLNLNV---NAM-----QKYL
Wee1a_Spur ---DLKSWSYMYMYGFKPQ-----------------------------------------
Wee1b_Spur RIPKTRQQNVANVNPFTPSAM---LQNATKKRLRQ-ERSI--------------------
AqueK218_Aque LRR--NTSKGTNINPFTPKDI---YTRSKRS-R---------------------------
Wee1B_Mmus DE--KTSLSLVNINPFTPETYRKLLLQSKGKRK---TRDY--------------------
Wee1_Mmus REFDTRQTPQVNINPFTPDPV---LLHSSGRCRGR-KRAY--------------------
: *. .
Wee1_Hsap WNDSCGEDM-EA-SDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKC
Wee1B_Hsap LEEA------GP--EEGK--GGLPAKRCVLRETNMASRYEKEFLEVEKIGVGEFGTVYKC
DDB0220004_Ddis NNNN-NNN-NN-NNDDTCNNNNNNSQNIDNNLITKFSLYKHTFQELDLIGEGSFGHVYKV
wee_Dmel LSDACDDDVTEEAGDSMREIHQQAPKRLALHDTNI-SRFKREFMQVNVIGVGEFGVVFQC
Wee1a_Spur ----------------------------------------------C-------------
Wee1b_Spur LDDD--EDL-DD--DMDGSYTENPAKRIALRDSDI-SRYEAEFVEVGKVGSGEFGSVYKC
AqueK218_Aque ------EDT-ERACASEH--GGGKRKALALRESNI-YRYREEFHEVCIIGSGSFGVVYKC
Wee1B_Mmus LEET------GE--EESKSVQWLPAKRSILQETNMASRYEKEFFEIEKIGVGEFGTVYKC
Wee1_Mmus FNDS-SEDM-EA-SDYEFEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKC
Wee1_Hsap VKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQN
Wee1B_Hsap IKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQN
DDB0220004_Ddis RHRIDGCLYAIKKTKKPLKGQKDRDIVLREVYGLSAIKDHTNIVRYFNAWEEDSHIFIQM
wee_Dmel VNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDHMLIQN
Wee1a_Spur ------------STGVPGQDTPFRQMALNEVYAHAVLGTHIHVVRYYSAWSEAGHMIIQN
Wee1b_Spur INRLDGCFYAIKKSKRPIAGSAFEQMALNEVYAHAVLGTHIHVVRYYSAWSEAGHMIIQN
AqueK218_Aque INRLDGCVYALKRSHKPVVGSADEPAALREVYAHAVLGSHPHLVRYYSAWAEDDHMLIQN
Wee1B_Mmus IKRLDGCIYAIKRSAKSFSGLSNE-LDLHEVYAHAVLGHHPHVVRYYSSWIEDDHVVIQN
Wee1_Mmus VKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHPHVVRYFSAWAEDDHMLIQN
: . . *.**:. :.: * ::***:.:* * .*:.**
Wee1_Hsap EYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISR
Wee1B_Hsap EYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICH
DDB0220004_Ddis EHCNGGNIYKWVTEHIK----QSESNLLLLAKQILTGIVYIHSLGLVHLDIKPENIYIIY
wee_Dmel EFCDGGSLHARIQDH-----CLGEAELKIVLMHVIEGLRYIHSNDLVHMDLKPENIFSTM
Wee1a_Spur EYCNGGSLADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP-------
Wee1b_Spur EYCNGGSLADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKPGNIFISK
AqueK218_Aque EYCNGGTLSSLISKIHKSTLRFNEVQLNRLIQHLAMGLTYIHSMGLVHLDIKPENVFISL
Wee1B_Mmus EYCNGGSLQAAISENTASNNHFQEPKLKDILLQISLGLKYIHNSGMVHLDIKPSNIFICH
Wee1_Mmus EYCNGGSLADAISENYRVMSYLTEVELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISR
*.*:**.: : . * :* : :: *: ***. .:**:*:**
Wee1_Hsap TSI-PNAA-------------S------------EEG-DEDDWA----------------
Wee1B_Hsap KMQS-ESS-----------G-V----------IEEVENEADWFL----------------
DDB0220004_Ddis KCNQ-NQIITNNNNTCSINNSSNGSDSYFKSKIKTTENDLDNFITTTNSVNNNNCNNNNN
wee_Dmel NPN-AHKLVEVQPQQT---KDDD--------GMDSVY-EELRHS----------------
Wee1a_Spur ------------------------------------------------------------
Wee1b_Spur KEPLPSTT-PES---E---KIDE---------EEEEGATEDNTP----------------
AqueK218_Aque PTL-PDSRLPPQAEV-----------------------SWDSLL----------------
Wee1B_Mmus KMQC-DSP-----------V-G----------PEEAESEADWFL----------------
Wee1_Mmus TSI-PNAV-------------S------------EEG-DEDDWI----------------
Wee1_Hsap -----------------------SNKVMFKIGDLGHVTRISSPQV-EEGDSRFLANEVLQ
Wee1B_Hsap -----------------------SANVMYKIGDLGHATSINKPKV-EEGDSRFLANEILQ
DDB0220004_Ddis NNVDNQNNNNQNNYLIIDGNKINFNSITFKIGDLGLLNEATNTKIYSEGDSRYLSRELLH
wee_Dmel -----------------------ENLVTYKIGDLGHVTSVKEPYV-EEGDCRYLPKEILH
Wee1a_Spur -------------------------------GDLGHVTSISNPKV-EEGDVRFLPVEILQ
Wee1b_Spur -----------------------LASLIYKIGDLGHVTSISNPKV-EEGDVRFLPVEILQ
AqueK218_Aque -----------------------MSEALYKIGDMGHVTSVKSPQV-EDGDCRFISREVLQ
Wee1B_Mmus -----------------------NASVMYKIGDLGHATSISKPKV-EEGDTRFLANEILQ
Wee1_Mmus -----------------------SNKVMFKIGDLGHVTRISSPQV-EEGDSRFLANEVLQ
**:* . ... : .:** *::. *:*:
Wee1_Hsap ENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRI---------PQVLSQ
Wee1B_Hsap EDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRKGNFPDV---------PQELSE
DDB0220004_Ddis DDMSALKKSDIFSLGCTLYELARCKPLPKSGMEWDSIRNGILSFEKEDSIYDDNKNDFST
wee_Dmel EDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWHNLRDGKVPIL---------PS-LSR
Wee1a_Spur EEHTHLTKADIFALALTAYLAAGGESLPKNGDDWHRIRQGHFPPL---------LH-IST
Wee1b_Spur EVRS----KDAFHSHITMVIILG-------------------------------------
AqueK218_Aque EDYSSLLESDVFSLGLTVYCAGSLCDLPKNGPEWHRIRDGHLPAL---------SQ-CSE
Wee1B_Mmus ENYQHLPKADIFALGLTIAVAAGAESLPINGDMWHHIRKGNFPEI---------SQELSD
Wee1_Mmus ENYSHLPKADIFALALTVVCAAGAEPLPRNGEQWHEIRQGRLPRI---------PQVLSQ
: * * *
Wee1_Hsap EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKS-----AEQLRIELNAEKFKNSLLQ
Wee1B_Hsap SFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKT------EELQQQLNLEKFKTATLE
DDB0220004_Ddis EFWQLIKSMIHPDPSVRPSAEQLLEHPLIKYGVIEIDDFENEIETLKNLLAEKEKVLIIQ
wee_Dmel DFNELIAQMMHPYPDKRPTSQSIFSHPILSAVDSKS-----KLQLGLELTVEKRKNEILM
Wee1a_Spur DLVDLLQTMIDPDPSQRPSASALVQHPLLCPNSKRS-----FTQLKRELNVAKFQNAILS
Wee1b_Spur ------------------------------------------------------------
AqueK218_Aque HFNKLLLSLVHSSPSKRPTASELQSHPIVCPSTEKT-----KAQLMKELNEEKLKNQILT
Wee1B_Mmus DFYGLLKNMIHPAPKERPSAAALARSRILWPFLEKT------DELQKQLNLEKSKTATLK
Wee1_Mmus EVTELLRVMIHPDPERRPSAMELVKHSVLLSASRKS-----AEQLRIELNAEKFKNSLLQ
Wee1_Hsap KELKKA------------------------------------------------------
Wee1B_Hsap RELREA------------------------------------------------------
DDB0220004_Ddis KEKQKLRQNQLQQKMQQPNFIELKQQPQQQQEKQQMLHQQKQQYLEQHNNNNDNNNNEFD
wee_Dmel NKLREA------------------------------------------------------
Wee1a_Spur RELNEA------------------------------------------------------
Wee1b_Spur ------------------------------------------------------------
AqueK218_Aque RELRDL------------------------------------------------------
Wee1B_Mmus RELKKA------------------------------------------------------
Wee1_Mmus KELKKA------------------------------------------------------
Wee1_Hsap -------------------------QMAKA-AAEERALFTDRMATRSTTQSNRTSRLIGK
Wee1B_Hsap -------------------------QQAQS-PQGYTH-HGDTGVSGTHTGSRSTKRLVGG
DDB0220004_Ddis ESEKEYQIQLEQFKIQKMQFQLQQEQLQYQHQHKHQNFFT--------------------
wee_Dmel -------------------------KKQIKLLEQRVNLL---AV----T--NNPD-SLD-
Wee1a_Spur -------------------------RKSTMNPP-------------PKSR-SNAGRLIGK
Wee1b_Spur ------------------------------------------------------------
AqueK218_Aque -------------------------REFSKSKRK-NKY------------------LIGG
Wee1B_Mmus -------------------------RHIQT-PQREVH-HCYYQI---CKGSR--HLLVGG
Wee1_Mmus -------------------------QMAAKVAAEERALFTDRMATRSTTQSNRTSRLIGK
Wee1_Hsap --KMNRSVS------------------------LTIY
Wee1B_Hsap --KSARSSS------------------FTSGEREPLH
DDB0220004_Ddis ---------KQICTASQIEGGI----------KNMAL
wee_Dmel GQRCLRSFTRRMRTPFSSHGKFDSISDRNKN-VITNI
Wee1a_Spur --KVNRSMS------------------------LTIY
Wee1b_Spur --------I------------------------MIVM
AqueK218_Aque GARGCRSM----------------------S-ADAFY
Wee1B_Mmus --RRKAPSS------------------FTRG--TSSV
Wee1_Mmus --KMNRSVS------------------------LTIY