Gene GL50803_113456 (G.lamblia)

GL50803_113456

Species: G.lamblia
Alias: GL50803_113456, GK073
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: VPS15

Sequence

Name Sequence Type Origin Length Description Download
GL50803_113456.AA Protein None 2088 None Fasta, JSON
GL50803_113456.kin_dom Protein Kinase Domain None 245 None Fasta, JSON

Protein domain

Protein domains of GL50803_113456.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_113456.AA VPS15 26-290 25 1.6e-20 67.74 In-house 1-296 (296) Show / Hide 
Range on Protein: 26-290
Range on HMM: 1-296/296
Sequence Identity: 25% (78 aa)

VTSFEALNTSRFLKSYHAENPQTKQDFILKVFVK-LEDIDLSIFKFMLSHYREKINRCC-PHVLPYMGEYESKTHGFLIRPMLYQSLPEFILQNPWLTRG
.   . |. .||.|   |  .     .  |||||      |  .| ..   . ...     ...||  . |.   . ..|  .  .|   |   | |.  
CHYVKNLGSTRFMKVCKAKHHE--GYIVVKVFVKHDDTYSLEPYKQRIEEIKKNLMQHPAFNCCPYQKVIETDKAAYMMRQYVKHNLYDRISTRPFLQMI

HKVLYSIQMILAVKEMHEAG-LVHGDIKLSNFLVTHTHSLMLTDFAPFKPYQVSMSNPVALSYYF------TDTIAPERIV---QADEELDT--------
 |  .  |   |..  | .|  .|||||..| ||| .  . |||||.|||      ||   ...|      | .||||| |   . |...          
EKKWIAFQTLCALEQCHKQGNVCHGDIKSENILVTSWNWCYLTDFACFKPCYLPEDNPADFTFFFDTSRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHT

-----LLLP------TMEADVFSLGSALLELWTSI--KPFDLPTLFEYRDAKTGNIINYVL---SLLDHITHEELRGLVHAMINPI-PSQRIDLSTL--Q
     ...|      | . | ||.| ...||..     |||.  |..||         |     ...  |  | .| |.| ||.   |..|. .  .  .
DSIDRQQNPWLFGELTPAMDIFSAGCVIAELFCEGDQPPFDYSQLCKYRSGE------YHPNREQIMEKIQDEHIRNLCHHMIQKDNPMKRMSCEEYLNK

IRSI
 |..
WRGF
Kinase GL50803_113456.AA S_TKc 32-291 12 2.4e-11 -10.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 32-291
Range on HMM: 1-231/231
Sequence Identity: 12% (36 aa)

LNTSRFLKS------YHAENPQTKQDFILKVFVKLEDIDLSIFKFMLSHYREKINRCCPHVLPYMGEYESKTHGFLIRPMLYQ---SLPEFILQNP----
    | . .      | . .  |.. . .|.            . ...  .   .  .|..  . . ... .| ...  .. .   .| ..| ...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

--WLTRGHKVLYSIQMILAVKEMHEAGLVHGDIKLSNFLVTHTHSLMLTDF---APFKPYQVSMSNPVALSYYFTDTIAPERIVQADEELDTLLLPTM-E
  ...  |   |  |...|.. .|. | .| |.| .| |...   ....||   . .        . .  . ..   .||| .             .  .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWY---MAPEVL-----------GYGKCK

ADVFSLGSALLELWTSIKPFDLPTLFEYRDAKTGNIINYVLSLLDHITHEELRGLVHAMINPIPSQRIDLSTLQI-------RSIF
.|. |.|  | |. .   ||.        .... ..|            .|.. ..  . .  |..|.    .            |
CDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_113456.AA CK1 130-167 27 4.5e-09 27.87 In-house 139-192 (339) Show / Hide 
Range on Protein: 130-167
Range on HMM: 139-192/339
Sequence Identity: 27% (15 aa)

IQMILAVKEMHEAGLVHGDIKLSNFLVTHT----------------HSLMLTDF
|||. |...||..| .| ||| .||..                   . . . ||
IQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDF
Kinase GL50803_113456.AA AGC 128-167 28 9.3e-09 17.24 In-house 151-199 (395) Show / Hide 
Range on Protein: 128-167
Range on HMM: 151-199/395
Sequence Identity: 28% (14 aa)

YSIQ-------MILAVKEMHE-AGLVHGD-IKLSNFLVTHTHSLMLTDF
|  .       ..||.  .|.  | .| | .|. | | ..   ..||||
YAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF
Kinase GL50803_113456.AA Ciliate-E2 128-167 31 1.1e-08 25.98 In-house 165-200 (365) Show / Hide 
Range on Protein: 128-167
Range on HMM: 165-200/365
Sequence Identity: 31% (13 aa)

YSIQMILAVKEMHEAG-LVHGDIKLSNFLVTHTHSLMLTDF
|  ..|||....|. .  .| |||..| |.     . ..||
YIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDF
Kinase GL50803_113456.AA CAMK 131-167 22 4.1e-08 21.49 In-house 187-240 (425) Show / Hide 
Range on Protein: 131-167
Range on HMM: 187-240/425
Sequence Identity: 22% (12 aa)

QMILAVKEMHEAGLVHGDIKLSNFLVTHTH-----------------SLMLTDF
|.. ||. .|. . || |.|. | |... .                  . ..||
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF
Kinase GL50803_113456.AA Ciliate-C3 129-167 41 4.9e-08 25.18 In-house 102-140 (140) Show / Hide 
Range on Protein: 129-167
Range on HMM: 102-140/140
Sequence Identity: 41% (16 aa)

SIQMILAVKEMHEAGLVHGDIKLSNFLVTHTHSLMLTDF
| |.. |.  .||  .||||||.|| |.   . . . ||
SKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF
Kinase GL50803_113456.AA Kin4 131-167 48 8.2e-08 19.41 In-house 118-154 (273) Show / Hide 
Range on Protein: 131-167
Range on HMM: 118-154/273
Sequence Identity: 48% (18 aa)

QMILAVKEMHEAGLVHGDIKLSNFLVTHTHSLMLTDF
|.|  |. ||  |||| |.|| | |.     |..|||
QLISGVHYMHYKGLVHRDLKLENLLLDKHENLVITDF
Kinase GL50803_113456.AA CDK-DD1 136-167 40 1.3e-07 18.93 In-house 111-142 (379) Show / Hide 
Range on Protein: 136-167
Range on HMM: 111-142/379
Sequence Identity: 40% (13 aa)

VKEMHEAGLVHGDIKLSNFLVTHTHSLMLTDF
..|.| .|  | ||| .| |..   .| .|||
INECHNQGIMHRDIKPANLLINNRGDLKITDF
Kinase GL50803_113456.AA MSK 131-167 32 5e-07 19.79 In-house 109-148 (277) Show / Hide 
Range on Protein: 131-167
Range on HMM: 109-148/277
Sequence Identity: 32% (13 aa)

QMILAVKEMHEAGLVHGDIKLSNFLVTHT---HSLMLTDF
. ..||. ||. | .|.|.|. | | .       . |.||
ELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDF
Kinase GL50803_113456.AA CMGC 95-167 15 2e-06 16.15 In-house 126-248 (513) Show / Hide 
Range on Protein: 95-167
Range on HMM: 126-248/513
Sequence Identity: 15% (19 aa)

SKTHGFLIRPMLYQSLPEFILQNP---------WLTRGH------------KVLYS------IQMILAVK--EMHEAG--LVHGDIKLSNFLVTHT----
.  | .|.   . ..| ..| .|.          |.  |            .  ..       |.. ..|   .| ..   .| |.| .| |..|.    
HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELI

----------------HSLMLTDF
                  | . ||
TRMMWKSEDWNPCQKNGRLKICDF
Kinase GL50803_113456.AA Pkinase 108-167 19 4e-06 22.77 Pfam 89-156 (293) Show / Hide 
Range on Protein: 108-167
Range on HMM: 89-156/293
Sequence Identity: 19% (13 aa)

QSLPEFIL--QNPWL--TRGHKVLYSIQMILAVKEMHEAGLVHGDIKLSNFLVTHTHSL----MLTDF
..| ..|   .. ..  .  .   |  |.. ... .|. | .| |.|..|.|. ..  .     ..||
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF