Gene P38c (Fruit Fly)

P38c

Species: Fruit Fly
Alias: SFO170, P38c
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 91E1--2,

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
P38c.NA RNA None 1071 None Fasta, JSON
P38c.AA Protein Various 356 None Fasta, JSON
P38c.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 286 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of P38c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase P38c.AA p38 20-305 56 7.29999999999e-200 670.26 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-305
Range on HMM: 1-289/289
Sequence Identity: 56% (164 aa)

YEFVRFLGGGSFGQVAKVRLRGTENY---FAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRS
|......|.|..|||.|...|.|...   .|.|.|||||..|..||.||||.||||||.|.|||.||.||.||||.|..||.||.|||.|.|||......
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

KRMSDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADKMTDHVGTMWYLAPEIIFLRGQYTKAIDVWSVGCILAELITD
.|.||..|....||||||||||||||..||||||.|||||...|.|||||||.|.|.|.||..|.|.||.||||......||...|.||||||.|||||.
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITG

RVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPLRQRCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYL
|.||.|.....|........|||..||...|..|..|||...|| ..|.||||.|||...|||||.|||||..|.|||||.||| |||.
RTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase P38c.AA MAPK 20-305 39 7e-157 527.48 In-house 1-328 (328) Show / Hide 
Range on Protein: 20-305
Range on HMM: 1-328/328
Sequence Identity: 39% (131 aa)

YEFVRFLGGGSFGQVAKVRLRG------TENYFAMKRLMRPFEREEDAKGTYREIRLLKHM-NHRNVISLLNVFHP----PAHNMMEFQQVYLVTHLMDA
|. ....| |..|.|.... .       .... | |...|||. . ..| |||||.||.|. .| |.|.||..|.|    ......||...|.|..||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHRYSRSKR-MSDQEIRIILYQILRG--LKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADK-----------------MTDHVGTMWYLAP
|||.  .| . .||. |. ..||||||  |||||||.|.||||||.||.|| | ...|.||||.| ....                 ||..| | || ||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIIFLR--GQYTKAIDVWSVGCILAELIT-DRVLFRGENYVSQIRCLINIMGTPTREFITGIS-MERSRNYLEGY---PLRQRCDFHHLFMG----YDVQ
||.. .    ||||.|.||||||.||..|  ..||.|..|. |. . ....|||..|||  |.  |. |||....   | .........| .     . |
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AIDLMEKMLEMVPEKRITAAEAMLHPYL
||||.||||.. |.||||..||. |||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase P38c.AA CMGC 20-305 24 2.5e-118 390.7 In-house 1-513 (513) Show / Hide 
Range on Protein: 20-305
Range on HMM: 1-513/513
Sequence Identity: 24% (125 aa)

YEFVRFLGGGSFGQVAKVRL--------------RGTENYFAMKRLMRPFEREEDAK----------GTYREIRLLKHMN-----------------HRN
|| .. .| |..|.| | |               . |... |.|....||  ||.||           ..|||..|||.|                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VISLLNVFHPPA--HNMME--------FQQVYLVTHLMDADLHRYSRSKR----------MSDQE------------IRIIL------YQILRGLK--YI
...|...|...   .|  |        |...|||. .|| ||..| ....          .|. .            |. ..      ||||||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAG--VVHRDLKPCNIAVNGNSEV--------------------RILDFGLSRMCADK------------------------MTDHVGTMWYLAPEIIF
||..  ..|||||| || .| | |.                    .| ||||.|   .                         .|. | |.|| ||||..
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

LRGQYT---------KAIDVWSVGCILAELITD--------RVLFR-----------GENYVSQIRCLINIMGTP----------------TREFITGIS
  ..||         ..||.||||||.||..|         . ||            |.... |. . ....|||                ..|... |.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------MERSRNYLEG---YPLRQRCDFHHLFMGYDV-----------------------------------QAIDLMEKMLEMVP
                    .|  |||..    .| ... ... || ...                                    |||||..|||.. |
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

EKRITAAEAMLHPYL
.|||||..|. |||.
DKRITAEQALQHPYF
Kinase P38c.AA ERK 20-305 38 3.6e-91 309.19 In-house 1-307 (307) Show / Hide 
Range on Protein: 20-305
Range on HMM: 1-307/307
Sequence Identity: 38% (120 aa)

YEFVRFLGGGSFGQVAKVRLRG-----TENYFAMKRLMRPFEREEDAKGTYREIRLLKHMN-HRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRY
|... ..| |..| |....  .     |..  | |  ...|. . ..| |.|||.||.| . | |.|.|.... |   .  ..  .|.|. ||. |||. 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE--QYNDIYCVEELMETDLHQI

SRSK-RMSDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSR----MCADK-------MTDHVGTMWYLAPEIIFLRGQYTKAI
 .|. . ||. .   .||||.||||||||.|.|||||| || || |    | ||||.|      ..        ||. | | || ||||.     ||||.
INSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAM

DVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTP-TREFITGISMERSRNYLEGYPL--RQRCDFHHLFMGYD--VQAIDLMEKMLEMVPEKRITA
|.||.|||.||..  . ||.|..|| ||.  ..|.||| . | .  |  |. ..|.  .|   |.  ..  .|   .   ||||| ||||.  |.||||.
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITV

AEAMLHPYL
.|.  |||.
EECLEHPYF
Kinase P38c.AA ERK5 20-305 40 6e-89 301.8 In-house 1-295 (295) Show / Hide 
Range on Protein: 20-305
Range on HMM: 1-295/295
Sequence Identity: 40% (121 aa)

YEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKR-
|. .  .| | .| |.  | | . .  |.|..   |.    || |.||...|.|  | |.| . .. . |   . |...|| |  ||..|||    |   
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILM-PKVPYSEMKDVYVVFDLMESDLHQIIHSNQP

MSDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSR-MCA---DK----MTDHVGTMWYLAPEIIFLRGQYTKAIDVWSVGCIL
..   ||  ||||||||||.||| |.|||||| |. || | |..| |||. | .|    ||    ||. | | || |||..|   .||.||||||||||.
FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIF

AELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEG-YPLRQRCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYL
 |.|. | .| | ||. |.. .. ..|.|    |  .| .. .||.   .| ||  |. ... . | ||.||. .||   | .|||...|. ||.|
GEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase P38c.AA S_TKc 20-305 28 4.9e-84 286.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-305
Range on HMM: 1-231/231
Sequence Identity: 28% (87 aa)

YEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDA---DLHRYSRS
||..| .| |.||.| |.| ..|  ..|.|..          . ..|||..||. .| |.. |. ||.         . .|.|. ..|    ||..| ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKK

KR-------MSDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADKMTDHVGTMWYLAPEIIFLRGQYTK-AIDVWSVGC
..       ..  ..| ..|||...|.|.|| |..|||||| || ..   .. | ||||.|      |  .|| ||.|||..    .|.| ..|.||.||
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

ILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPLRQRCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAML-------
||.|... . .|.      |.  .....|                                     . .|.|...|.|.. ||||.|| ||.        
ILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

HPYL
||..
HPWF
Kinase P38c.AA ERK1 20-305 39 3.5e-82 279.33 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-305
Range on HMM: 1-289/289
Sequence Identity: 39% (117 aa)

YEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKRM
|  ....| | .| |.    . ...  |.|..  |||     . | |||..|.  .| |.| . .. .  |. . ... ||.|  ||. || .  .....
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR--ADTIEQMRDVYIVQCLMETDLYKLLKTQHL

SDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADKMTDHVG-------TMWYLAPEIIFLRGQYTKAIDVWSVGCILAE
|   |   |||||||||||||| |.|||||| |. .|   ...| |||| |. ||  .|| |       | || ||||.     |||.||.|||||||||
SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARI-ADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE

LITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPLRQRCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYL
..  | .| |  |. |.  .. ..| | .. .  |  |. ||||.. | ...  ...|| . | .|.||..|||   |.||||  ||. ||||
MLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase P38c.AA ERK7 20-305 36 5.3e-81 275.42 In-house 1-292 (292) Show / Hide 
Range on Protein: 20-305
Range on HMM: 1-292/292
Sequence Identity: 36% (108 aa)

YEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMN-HRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSR-SK
||  . || | .| | |.  . | .  |.|.    |  . ||  |.||| .|. .. | |.|.|.||..  |.|   .   |||   |..|||   |  .
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR--ADNDRDI---YLVFEFMETDLHAVIRKGN

RMSDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADKM---------TDHVGTMWYLAPEIIFLRGQYTKAIDVWSVGC
 . |   . |.||.|| .||.||. |.|||||| || .. .  |.. |||| |  |..          |. | | || ||||     .|||..| ||.||
ILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGC

ILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPLRQRCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYL
||.|..... .| |   . ||   ..... ||.| |  |  . . | ||  . ..|  ..... .   .||||. ..| . |.||.|| .|. ||| 
ILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase P38c.AA Pkinase 20-305 29 7.4e-79 273.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-305
Range on HMM: 1-293/293
Sequence Identity: 29% (94 aa)

YEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYR--EIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDA-----DLHR
|...| .| ||||.| | . .||.  .|.|.. .. |...  .   |  ||...|..|| |.. |. .|.         . .|.|. ...      ||..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-------KDHIYMVMEYCEGGLYVMDLFD

YSR---SKRM--SDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEV----RILDFGLSR---MCADKMTDHVGTMWYLAPEIIFLRGQYTKA
| .   ....  |..|.. ..|||||||.|.|| |..|||||| || .. | ..    .| ||||..      . ||. .|| ||.|||.|  .  |...
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPK

IDVWSVGCILAELITDRVLFRGE----NYVSQIRCLINIMGTPTREFITGI-----SMERSRNYLEGYPLRQRCDFHHLFMGYDVQAIDLMEKMLEMVPE
.|.||.||||.|... | .|.|.    | ..|. .. .|||.|... .        .. ... . .        . | .|   .  ..|.....|.. |.
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------F-HWTFHNWSEECKDFIKWCLCKDPK

KRITAAEAMLHPYL
||.||.... ||..
KRPTAEQILQHPWF
Kinase P38c.AA nmo 21-305 36 7.8e-76 232.53 In-house 2-292 (292) Show / Hide 
Range on Protein: 21-305
Range on HMM: 2-292/292
Sequence Identity: 36% (107 aa)

EFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRS-KRM
.  | .| | || |  |         |.|..   |     .|  .||...|   .| ||.|.|.. .||  .   || .| || || .|||.   | . .
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDF--FQEIYVVTELMQSDLHKIIVSPQHL

SDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMC----ADKMTDHVGTMWYLAPEIIFLRGQYTKAIDVWSVGCILAELIT
|   ... ||||||||||.|||...|||.|| |. || |  ..| |||| |.     . .||  | | .| ||||.    .|| |.|.|||||| |||. 
SSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLG

DRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPLRQRCDFHHLFMGY----DVQAIDLMEKMLEMVPEKRITAAEAMLHPYL
 |.||  .. . |.  .....|||. | .     |  .. .   |... |      .         |..|. .||   |.||| . .|. ||||
RRILFQAQSPIQQLQMITDLLGTPSMEDMK-YACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase P38c.AA JNK 47-265 37 4e-68 232.64 In-house 28-251 (309) Show / Hide 
Range on Protein: 47-265
Range on HMM: 28-251/309
Sequence Identity: 37% (84 aa)

AMKRLMRP--FEREEDAKGTYREIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRS--KRMSDQEIRIILYQILRGLKYIHSAG
| | .|||  |.    .|  |||  ..|. || |.|...|.|  |. .. ||| ||.|  .||. |.  . |   .   . .  ..||...| |. ||.|
AIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFT-PQETLEEFQDVYIVMEYMDWNLCQVIHSTFMELDHERMSYLFYQMCCGIKHLHSMG

VVHRDLKPCNIAVNGNSEVRILDFGLSRMCADK--MTDHVGTMWYLAPEIIFLRG-QYTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTP
. |||||| || ||    . |.|||..|    .  ||. |.| .| |||.|   .  |.  .|.||||||.||.|. .|||.|. .  |    |   |||
IIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEMIRHHVLFPGKDHIDQWNKIIEFLGTP

TREFITGISMERSRNYLEGYPLRQRC
...|.     .  |||.|.... ...
DPHFMMQM-QPHVRNYVENRNMDPYY
Kinase P38c.AA MAPK-Unclassified 20-170 38 1.5e-51 177.56 In-house 1-157 (575) Show / Hide 
Range on Protein: 20-170
Range on HMM: 1-157/575
Sequence Identity: 38% (61 aa)

YEFVRFLGGGSFGQVAKVRLRGT-ENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDA---DLHRYSR
||    .| |..|||..     .   . | |.. . |. . |.| . ||||.| ..|| |.| . ..| .      ||. .|.|. .|     |||   .
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SKR--MSDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSR
|     ..| |....|||||||||.|||...|||||| |. .|..  ||| |||.||
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase P38c.AA MAPK-Unclassified 176-305 28 1.1e-36 128.22 In-house 405-575 (575) Show / Hide 
Range on Protein: 176-305
Range on HMM: 405-575/575
Sequence Identity: 28% (48 aa)

MTDHVGTMWYLAPEIIFLRGQYTKAIDVWSVGCILAELITD-----------RVLFRGEN--------------------YVSQIRCLINIMGTPTREFI
|| .| | || ||||... . |....| ||.|||.||..             | || |..                    ...||  ..   |.|  | .
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

TGISMERSRNYLEGYPLRQRCDFHHLFMGYDV----------QAIDLMEKMLEMVPEKRITAAEAMLHPYL
  |   . | |...     . .|  |.               ..||.  |||   | ||||| .| .||| 
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase P38c.AA TyrKc 20-305 22 5e-14 4.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-305
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

YEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHM--NHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDA-DLHRYSRS
 .. . || | ||.| | ...      | | |          .  .||.|....   .| |.. |. |   .  | |. .....|. .|.  ||. | |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KR--MSDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADK-------MTDHV----GTM--W---YLAPEIIFLRGQYT
.|   . ..   . .|| .|  |.|| ...||||   |. |. |  |.| ||||||   |.        . ..    |.   .    .||| |   | .|
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

KAIDVWSVGCILAELITDRVLFRGE-----NYVSQIRCLINIMGTPTREFI--TGISMERSRNYLEGYPLRQRCDFHHLFMGYDVQAIDLMEKMLEMVPE
 . |||| |  . |. |.      .        .... ..   . . .       .|                      | .      ..|..  .  ||
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS----------------------FVCCPDEMYQIMKQCWHEDPE

KRITAAEAMLHPYL
.| | .|   | ..
DRPTFSEI--HECF
Kinase P38c.AA JNK 277-305 41 3.8e-05 15.19 In-house 281-309 (309) Show / Hide 
Range on Protein: 277-305
Range on HMM: 281-309/309
Sequence Identity: 41% (12 aa)

QAIDLMEKMLEMVPEKRITAAEAMLHPYL
.| ||  .||   |..||   .|  |||.
MARDLLFRMLVINPDDRISVDDALQHPYI
Kinase P38c.AA Pkinase_Tyr 20-83 26 0.004153 11.15 Pfam 1-70 (270) Show / Hide 
Range on Protein: 20-83
Range on HMM: 1-70/270
Sequence Identity: 26% (19 aa)

YEFVRFLGGGSFGQVAKVRLR----GTENYFAMKRLMRPFEREED--AKGTYREIRLLKHM-NHRNVISLL
 .| . || |.||.| | ...    .|.   | | | ..   .|.   .   ||....|.. .| |...|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase P38c.AA Pkinase_Tyr 127-215 34 0.281175 4.95 Pfam 116-209 (270) Show / Hide 
Range on Protein: 127-215
Range on HMM: 116-209/270
Sequence Identity: 34% (33 aa)

ILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSR--MCADKM-TDHVGTMW---YLAPEIIFLRGQYTKAIDVWSVGCILAELIT
. .|| .|. | .| . .||||   |. |. |  |.| ||||.|  .  |   . . |...    .||| |. .  .| . |||| |  . |..|
MCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMWEIFT