Gene IRE1 (Mouse)

IRE1

Species: Mouse
Alias: Ern1, IRE1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: IRE

Sequence

Name Sequence Type Origin Length Description Download
IRE1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON
IRE1.NA RNA Sugen 3976 None Fasta, JSON
IRE1.AA Protein Sugen 977 None Fasta, JSON

Protein domain

Protein domains of IRE1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ IRE1.AA PQQ 28-59 33 1.8e-07 32.04 SMART 1-33 (33) Show / Hide 
Range on Protein: 28-59
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

VTLPET-LLFVSTLDGSLHAVSKRTGSIKWTLK
 .. .  ...|.| ||.|.|....|| ..|| |
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE1.AA PQQ 33-70 28 0.000218 17.82 Pfam 1-37 (37) Show / Hide 
Range on Protein: 33-70
Range on HMM: 1-37/37
Sequence Identity: 28% (11 aa)

TLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHV
. ..| | || . |.  .|| .||. |..|. .  . .
GDVYVHTWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
PQQ IRE1.AA PQQ 110-142 30 6e-06 27.04 SMART 1-33 (33) Show / Hide 
Range on Protein: 110-142
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

PCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLS
|....||..| | ... .| .|  ||..  |  
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE1.AA PQQ 148-180 18 4e-06 27.55 SMART 1-33 (33) Show / Hide 
Range on Protein: 148-180
Range on HMM: 1-33/33
Sequence Identity: 18% (6 aa)

SLCPSTSLLYLGRTEYTITMYDTKTRELRWNAT
. . . ...|.|.........|.|| ...|...
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE1.AA PQQ 191-223 27 0.001689 18.87 SMART 1-33 (33) Show / Hide 
Range on Protein: 191-223
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

DDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQN
  |...  ..|. .|| . ..|...|.||| ..
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE1.AA PQQ 205-233 24 9.192649 2.4 Pfam 9-36 (37) Show / Hide 
Range on Protein: 205-233
Range on HMM: 9-36/37
Sequence Identity: 24% (7 aa)

DGLVVTVDSESGDVLWIQNYASPVVAFYV
|| .. .| ..|.|.|  .  .|... ..
DGYIYALDADTGKVKWKFKTGPPDWW-PM
PQQ IRE1.AA PQQ 279-310 24 0.180246 8.07 SMART 1-33 (33) Show / Hide 
Range on Protein: 279-310
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

KSKLTP-TLYVGKYSTSLYASPSMVHEGVAVVP
 ... . |.||| |. .|||  .   . .  ..
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
Kinase IRE1.AA IRE 574-832 50 1.2e-174 586.52 In-house 1-292 (292) Show / Hide 
Range on Protein: 574-832
Range on HMM: 1-292/292
Sequence Identity: 50% (148 aa)

KDVLGHGAEGTIVYKGMFDNRD-VAVKRILPECFSFADREVQLLR--ESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQ---------------
...||.|..||.|.||....|. ||||....|...|..||.|.|.  |||.|||||||.|.|.|.||.|.|.|||...||.||||               
NNILGRGCNGTLVFKGIWNGRIPVAVKQMQKEFNPFISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNN

--KDFA----HLG--LEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSM--PNAHG-RIKAMISDFGLCKKLAVGRHSFSR--RSGVPGTEGWIAPEM
  |...    ...  .....|..|...||.||||.||||||||||||| .|  ||.|| ....|||||||||.|..||.||.|  |||..||.||..|||
NNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNRFMISDFGLCKMLVEGRYSFTRNIRSGPTGTWGWHPPEM

LSEDCKDNPTYTVDIFSAGCVFYYVISEGNHPFG-KSLQRQANILLGACNLDCFHSDKHED-VIARELIEKMIAMDPQQRPSAKHVLKHPFF
|.|.|....|..|||||.|||||||...|.|||| ..|.|||||| |..|||......|.. |||..||..||..|||.||..|..|.||||
LQEFCQKRKTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYNLDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKECLNHPFF
Kinase IRE1.AA S_TKc 571-832 26 9.1e-56 192.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 571-832
Range on HMM: 1-231/231
Sequence Identity: 26% (73 aa)

FCPKDVLGHGAEGTIVYKGMFDN--RDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA---TLQEYVEQKDFAH----L
.   ...|.|| |. |||.   .  | ||.|.|       . ||.|.|..   |||..... .  | .. |.  |.|     .| .| ...        .
YEILRKIGKGAFGK-VYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

GLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTY-TVDIFSA
  .   ...|. ..|...||..|.|||||| ||||.          .|.||||...|          . . ||  ..|||.|        ..  .|. | 
PEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----------TTFCGTPWYMAPEVL------GYGKCKCDWWSC

GCVFYYVISEGNHPFGKSLQRQANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLK-------HPFF
||..|  .. |  ||   .|.  ....              .  |...|.|.  .||..||.|  .|.       ||.|
GCILYEMLC-GYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRE1.AA Pkinase 571-832 23 5.2e-44 156.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 571-832
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

FCPKDVLGHGAEGTIVYKGMFDNRD--VAVKRILPECFSFADR-------EVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-----TLQEYVE--
.. . ..| |. |.  ||..  .    ||||.|  .  .   .       |.|....   |||..|....  |..  |.  |.|        | .|..  
YHIGRKIGSGSFGCV-YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

-QKDFAHLGLEPI-TLLHQTTSGLAHLHSLNIVHRDLKPHNILLS---MPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKD
 .. |  .  . .   . |. .||...|| .|.|||||| |||..    ..|    .  |.||||.|..     . |  ... || ...||| . .. ..
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

NPTYTVDIFSAGCVFYYVISEGNHPFGKS-----LQRQANILLGACNLDCFHSDKHED-------------------VIARELIEKMIAMDPQQRPSAKH
  .. ||..|.||..|.... |. ||  .     .  .. | .  .    |....  .                     ....|......||..||.|..
--GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

VLKHPFF
.|.||.|
ILQHPWF
Kinase IRE1.AA Ciliate-E2 469-832 18 4.6e-42 142.16 In-house 14-365 (365) Show / Hide 
Range on Protein: 469-832
Range on HMM: 14-365/365
Sequence Identity: 18% (86 aa)

SVHQQRQ-LQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDPEFLDSSGPFSESSGTSSPSPSPRASNHSLHPSSSASRAGTSPSLEQDDEDEETRMVIVG
|| . .. .. .||.. ... |..|.||                                                                        
SVYKCKVWKVQKQFAIKIID-QKQQRQQ------------------------------------------------------------------------

KISFCPKDVLGHGAEGTIVYKGM---FDNRDVAVKRILPECFSFADREVQLLR---------------ESDEHPNVIRYF--CTEKDRQFQYIAIELCAA
                      |   ...  .|.|.. .    .  .| ...|               |.. |||.|...    |||..  |.  |.|  
----------------------MQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQG

-TLQEYVEQKDFAHLGL----------EPITLLHQTTS---------------GLAHLHSLN-IVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAV
 .|..| ....  ..            | ...  | ..               .| .||| | |.|||.|| |||.            |.||||.||.  
GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDD

----GRHSFSRR---------SGVPG----------------TEGWIAPEMLSEDCKDN------PTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANI
    ..| ....         |. ||                | |  |||.|.    ||       .| .||.|.|...|. .. |..||      | .|
DNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF-GKPPF------QQQI

LLGACNLDCFH-------------SDKHEDVIARELIEK----MIAMDPQQRPS-AKHVLKHPFF
. . ....|..             | |. .  .  || |    |.  ||..|.. .. .|.||.|
KQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase IRE1.AA CAMK 576-832 17 5.6e-38 119.45 In-house 1-425 (425) Show / Hide 
Range on Protein: 576-832
Range on HMM: 1-425/425
Sequence Identity: 17% (76 aa)

VLGHGAEGTIVYKGMFDNRD--------------VAVKRIL-------------------------------PECFSFADREVQLLRESDE------HPN
.||.|. | .|....  |                ||.| |                                |.   .  ||.....   .      |||
TLGRGSFG-KVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VIRYFC---------------TEKD-----RQFQYIAI---ELCAAT-----LQEYVEQKDF-------------AHL-GLEPITLLHQTTSGLAHLHSL
.|. .                | ..     ... |.     |.|        | .|. ..                ..   |  .. .|  |.....||.
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

NIVHRDLKPHNILLSMPNAHGR------------IKAMISDFGLCKKLAVGRHSF--------------------SRRSGVPGTEGWIA-PEMLSE----
||||||||| ||||.  | .               .  |.|||. .|.  |  .|                       . . || . .| ||.|.     
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------DCKDNP-TYTVDIFSAGCVFYYVISEGNHPFGKS---------------LQRQANILLGACNLD-------------CFHSDKHED------VI
      |..  . .. .|. |.|.. |   . |  ||  .                .   .|. | .. .             .. .|  ..        
NMQNATDEEKPYYGPKCDMWSCGVILYIMLC-GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

ARELIEKMIAMDPQQRPSAKHVLKHPFF
.. || ||   ||..|.... .|.||..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase IRE1.AA Ciliate-E2-Unclassified 473-832 15 3.6e-30 101.86 In-house 40-352 (352) Show / Hide 
Range on Protein: 473-832
Range on HMM: 40-352/352
Sequence Identity: 15% (69 aa)

QRQLQHQQFQKELEKIQLLQQQ-----QLPFHPHGDLTQDPEFLDSSGPFSESSGTSSPSPSPRASNHSLHPSSSASRAGTSPSLEQDDEDEETRMVIVG
|.| .... .. .|.... ...                                                                              
QKQIMNKD-EIMNEMKEMNNKKKYHQRK------------------------------------------------------------------------

KISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQ-LLRESDEHPNVIRYFCTEKDRQFQYIAIELC-AATLQEYVEQKDF-------
                                          ... | .|. .. ||.....| ...|.|  ||  |.|   .|..| ... .       
----------------------------------------Y-NKIMQQILLNHP-HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGND

--------AHLGLEPI------TLLHQTTSGLAHLHSLN-IVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAV---------------GRHSFSRR
         ..  . .      ... |  .|| .||. | |.|||.|| |||..  .   . .  |.|||..||.                  .. .. .
LFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTF

SGVPGTEGWI--APEMLSEDCKDNPT-YTVDIFSAGCVFYYVISEGNHPFG---KSL---------------QRQANILLGACNLDCFHS---DKHEDVI
.| |..      |||.| .   |... | .||.| |...|. .  |..||.   .                 | . ||. . .. ..|     .|| .  
CGTPNYMP-QYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF-GYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPE

ARELIE----KMIAMDPQQRPSAKHVLKHPFF
| ..|.    ||.  .| .|.... .|.||.|
AKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase IRE1.AA ULK 571-766 23 6.1e-28 94.67 In-house 1-248 (329) Show / Hide 
Range on Protein: 571-766
Range on HMM: 1-248/329
Sequence Identity: 23% (61 aa)

FCPKDVLGHGAEGTIVYKGM---FD---NRDVAVKRIL--PECFSF-----------ADREVQLLRESD-------EHPNVIRYFCTEKDRQF--QYIAI
.| ...||.|. |  ||||     .   | .||.| |.   .  .             ..|...... .        |||.....   .. ..   ||  
YCLNHCLGKGSFG-KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

ELCAA-TLQEYVEQKDFAHLGLEP-----------ITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAH---------GRIKAMISDFGLCKKLAVG
|.|   .|..| ...   .|...            |  ..|  .|. .||. ||.|||.|| |||.. ....         |..|  |.|||..|..  .
EYCNGGDLEQYIKKN--KKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLK--IADFGFAKHVDND

------RHSFS-RRSGVP---GTEGWIAPEMLSED--CKDNPTYTVDIFSAGCVFYY
       ....          ||    ||. |..   .|.  .|..||.| ||.||.
NMEQQMMMTCVNE----KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYE
Kinase IRE1.AA TKL 577-830 17 1.2e-27 96.59 In-house 1-364 (364) Show / Hide 
Range on Protein: 577-830
Range on HMM: 1-364/364
Sequence Identity: 17% (65 aa)

LGHGAEGTIVYKGMFDN----------RDVAVKRILPE----------------------------CFSFADREVQLLRESDE-HPNVIRYFCTEKDRQF
.| |. | .|||| . .          .|||||..  .                            .. .  .|....  |   |||....    .. ..
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------QYIAIELC-AATLQEYVEQKDFAHLGLEP--ITLLHQTTSGLAHLHSLN--------IVHRDLKPHNILLS-----------MPNAH
              .|  |.|   .| .|.           .  . . ... .|...||| |        |.|||||..|||.            .|||.
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

GRIKAMISDFGLCKKLAVGRHSFS----------------RRSGVPGTEGWIAPEMLSEDCKDN-------------PTYTVDIFSAGCVFYYVIS----
...|  |.||||.. .    ..                  ... . || .| |||.| .. ...              .  .|..| | |.. ...    
WCCK--ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

EGNHPFGKSL------QRQANILLGACNLDCF---------HSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHP
. ..|.   .      . .. . .  . . .             .. .   ..|...  ..||..|||.. .||. 
YYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRE1.AA STE 571-763 20 6.7e-27 92.09 In-house 1-257 (359) Show / Hide 
Range on Protein: 571-763
Range on HMM: 1-257/359
Sequence Identity: 20% (55 aa)

FCPKDVLGHGAEGTIVYK-----------GMF-----DNRDVAVKRIL--------------------PECFSFADREVQLLRESDE-HPNVIRYFCTEK
.   ...|.|| || ...           |        .. .|.|..                     .| .    .|........  |||...|.... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

D-------RQFQYIAIELCAA-TLQEYVEQKDFAHLGL-----------EPIT--LLHQTTSG-LAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISD
.       ..  .|. |.... .| . ...|     .|           |..    ..|.  | |..|||..|.|||.|| ||||          . ..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCD

FGLCKKLAV---GRHSFS------------RRSGVPGTEGWIAPEMLSEDCKD-NPTYT--VDIFSAGCV
||.|..|.    .  . |            .|  . ||  | |||... . .. .. |.  .|| | ||.
FGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCT
Kinase IRE1.AA CMGC 571-718 18 1.4e-25 80.28 In-house 1-254 (513) Show / Hide 
Range on Protein: 571-718
Range on HMM: 1-254/513
Sequence Identity: 18% (48 aa)

FCPKDVLGHGAEGTIVYKGMF----------------DNRDVAVKRIL-PECFS-FAD-------------REVQLLRES----------------DEHP
.   ...|.|. | .|||.                  .|. ||.|.|  |. .   |              ||...|..                 . |.
YEIIKKIGEGTYG-VVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

NVI--RYFCTEKD---------------RQFQYIAIELCAATLQEYVEQKDF-----AHLGLEPIT---------------LL------HQTTSGLA--H
|..  ..... |.                .  |.  |..  .| .| ... |       ..|..                 ..      .|   ||.  .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSLN--IVHRDLKPHNILLSMPNAH-----------------GRIKAMISDFGLCKKL
.|| .  |.|||||| |||..  .                   ||.|  | ||||....
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLK--ICDFGLARWY
Kinase IRE1.AA ULK 571-766 25 2.4e-24 83.3 In-house 1-244 (324) Show / Hide 
Range on Protein: 571-766
Range on HMM: 1-244/324
Sequence Identity: 25% (64 aa)

FCPKDVLGHGAEGTIVYKG--MFD---NRDVAVKRILPECFSFA-------------DREVQLLRESDE--HPN--VIRYFCTEKDR--QFQYIAIELCA
.| ...||.|. |  ||||  . .   | .||.| |    ..               ..|.|.... .|  |||  .....   ..    . ||  |.| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

A-TLQEYVEQKDFAHLGL---------EPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAH---------GRIKAMISDFGLCKKLAVG-RHSFS
  .|..| ...    .           | |  ..|  .|. .||. ||.|||.|| |||.. ....         |..|  |.|||..|..  .    . 
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLK--IADFGFAKHVDNNNMEQQM

RRSGVP-----GTEGWIAPEMLSED--CKDNPTYTVDIFSAGCVFYY
. . |      ||    ||. |..   .|.  .| .||.| ||.||.
CQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYE
Kinase IRE1.AA PEK 668-719 38 7.9e-14 43.82 In-house 432-483 (655) Show / Hide 
Range on Protein: 668-719
Range on HMM: 432-483/655
Sequence Identity: 38% (20 aa)

LLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLA
...|  .||...||  ..||||||.||.|.. . |.  .  | ||||.....
IFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHE
Kinase IRE1.AA TyrKc 571-832 22 2.4e-12 -23.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 571-832
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

FCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFAD--REVQLLRES-DEHPNVIRYF--CTEKDR-----QFQYIAIELCAA-TLQEYV-EQKDF
   ...||.|| | .||||. . ..|||| . ...   .|  || .....   .|||..| .  ||.. |     .  .|  |...   |..|  . .. 
ITLGKKLGEGAFG-EVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

AHLGLEPITLLH---QTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVG--------RHSFSRRSGVP--GTEGWIAPEMLSE
    | . .||.   |  .| ..||| |..||||   |.|.. ..      . ||||||....  .          . . ..|        | ||| .  
----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

DCKDN-PTYTVDIFSAGCVFYYVISEGNHPFG------KSLQRQANILLGACNLDCFHSD-------KHEDVIARELIEKMIAMDPQQRPSAKHVLKHPF
  ...  |   |..| | . . . . |  |        .| |.  . .     ... ..|        ....    ....  . || .||. . .  | .
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ--IMKQCWHEDPEDRPTFSEI--HEC

F
|
F
Kinase IRE1.AA CMGC 798-832 40 4.2e-11 31.78 In-house 479-513 (513) Show / Hide 
Range on Protein: 798-832
Range on HMM: 479-513/513
Sequence Identity: 40% (14 aa)

DKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF
.|..|  |..|..||  .||..|..|.  |.||.|
RKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase IRE1.AA PEK 805-832 50 1.3e-09 28.82 In-house 628-655 (655) Show / Hide 
Range on Protein: 805-832
Range on HMM: 628-655/655
Sequence Identity: 50% (14 aa)

ARELIEKMIAMDPQQRPSAKHVLKHPFF
....| .|. .||||||||.  |.|.||
QADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase IRE1.AA STE 806-832 41 6.5e-07 20.58 In-house 331-359 (359) Show / Hide 
Range on Protein: 806-832
Range on HMM: 331-359/359
Sequence Identity: 41% (12 aa)

RELIEKMIAMDPQQRPSAKHVLK--HPFF
.. |.|   .||..||.|.  ||  |||.
KDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase IRE1.AA PEK 571-601 39 7e-06 15.68 In-house 1-33 (655) Show / Hide 
Range on Protein: 571-601
Range on HMM: 1-33/655
Sequence Identity: 39% (13 aa)

FCPKDVLGHGAEGTIVYKG--MFDNRDVAVKRI
|. ...||.|. | .|||.  ..| .  |.|||
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRI
Kinase IRE1.AA ULK 806-832 33 0.008539 5.69 In-house 303-329 (329) Show / Hide 
Range on Protein: 806-832
Range on HMM: 303-329/329
Sequence Identity: 33% (9 aa)

RELIEKMIAMDPQQRPSAKHVLKHPFF
..|| .|.  |. .| |   ...||.|
KDLIRRMLQYDEKDRISWEELFNHPWF
Kinase IRE1.AA ULK 806-832 33 0.01009 5.56 In-house 298-324 (324) Show / Hide 
Range on Protein: 806-832
Range on HMM: 298-324/324
Sequence Identity: 33% (9 aa)

RELIEKMIAMDPQQRPSAKHVLKHPFF
..|| .|.  |. .| |   ...||.|
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase IRE1.AA CMGC 752-765 42 0.044093 1.59 In-house 313-326 (513) Show / Hide 
Range on Protein: 752-765
Range on HMM: 313-326/513
Sequence Identity: 42% (6 aa)

TYTVDIFSAGCVFY
|...|. |.||.|.
TTPIDMWSVGCIFA
Ribonuc_2-5A IRE1.AA Ribonuc_2-5A 837-963 51 1.1e-73 255.84 Pfam 1-137 (137) Show / Hide 
Range on Protein: 837-963
Range on HMM: 1-137/137
Sequence Identity: 51% (70 aa)

KQLQFFQDVSDRIEKEALD--GPIVRQLERGGRAVVK-MDWRENITVPLQTDLRKF-RT---YKGGSVRDLLRAMRNKKHHYREL-PVEVQETLGSIPDD
|.|.|..|||||.|.|  |   ||.. |||..|.||. .||...|  ....|..|. |.   |.|.||||||||||||||||.|. | |..|.||..||.
KRLRFLCDVSDRFEIEDRDPPSPILQALERTSRCVVGFGDWHKKIDKAFMDDMGKYYRKRKNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLPDG

FVRYFTSRFPHLLSHTYQAME--LCRHERLFQTYYWH
|..|||.|||||| |.|..|.   |.||..|. || .
FLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYKP
PUG IRE1.AA PUG 895-952 39 1.7e-25 91.94 SMART 1-66 (66) Show / Hide 
Range on Protein: 895-952
Range on HMM: 1-66/66
Sequence Identity: 39% (26 aa)

GSVRDLLRAMRNKKHHYREL--------PVEVQETLGSIPDDFVRYFTSRFPHLLSHTYQAMELCR
 |||||||.|||..||.||.        . ...|..|..|..| .|||..||.|..|.......|.
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK