Gene p38a (Mouse)

p38a

Species: Mouse
Alias: Mapk14, p38a
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
p38a.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON
p38a.AA Protein Sugen 360 None Fasta, JSON
p38a.NA RNA Sugen 3560 None Fasta, JSON

Protein domain

Protein domains of p38a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase p38a.AA p38 24-308 76 6.2e-236 790.09 In-house 1-289 (289) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-289/289
Sequence Identity: 76% (221 aa)

YQNLSPVGSGAYGSVCAAFDTKTGHR---VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTP-ARSLEEFNDVYLVTHLMGADLNNIVKC
||||.||||||||.||.|.|..||..   ||.|||.|||||.||||||||||||||||.|||||.||||||| |.|...|.|||.|||.||||||||.||
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG
|.|.|||.|||.|||||||||||||.||||||||||.||||||||.|||||||||.|||||||||||||||||||||||||.|||||||||||||||.||
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITG

RTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
||||||.|||.|||.||...|||........ |.||||||||..|||...|..||.||||.|.|||||||.||.||||||..|..|.||
RTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase p38a.AA MAPK 24-308 55 5.4e-207 693.96 In-house 1-328 (328) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-328/328
Sequence Identity: 55% (182 aa)

YQNLSPVGSGAYGSVCAAFDTKTGHR------VAVKKLSRPFQSIIHAKRTYRELRLLKHM-KHENVIGLLDVFTP-----ARSLEEFNDVYLVTHLMGA
||.|.|.|.|||| ||.|.|..|...      ||.||.|||||. .|.||||||..||.|. .|||.|.|||.|||     ..|||||||.|.|..||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLNNIVKCQK-LTDDHVQFLIYQILRG--LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-----------------MTGYVATRWYRAP
||..| |.|. |.|||.|...||||||  |||||||..|||||||||..|||.|.|||.||||||..|.|                 ||.||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--WMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHINQLQQIMRLTGTPPAYLINRMP-SHEARNYIQSL---AQMPKMNFANVFIG----ANPL
|||||  ||||...||.||||||.||.|| ...||||.|.|.|...|| ..|||.  .|.... |..||||||||    ..|| .....| .    |||.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AVDLLEKMLVLDSDKRITAAQALAHAYF
|.||||||||.| |||||...||.| ||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase p38a.AA ERK 24-308 49 4.4e-161 541.44 In-house 1-307 (307) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-307/307
Sequence Identity: 49% (153 aa)

YQNLSPVGSGAYGSVCAAFDTK-----TGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV
|| ....| |||| ||.|.|..     || .||.|| ...|   | .|||.||..||.| | |||.|.|.|.. | .| |..||.|.|. ||  ||  | 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMP-NSPEQYNDIYCVEELMETDLHQII

KCQ-KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDE-------MTGYVATRWYRAPEIMLNWMHYNQTVD
. |  |.|||.|...||||.||||||||..|||||||||. ||..| ||| ||||||    . ..        ||.||||||||||||||.|  |.. .|
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

IWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP-PAYLINRMPSHEARNYIQSLAQ--MPKMNFANVFIGAN--PLAVDLLEKMLVLDSDKRITAA
|||.|||.||.| ...|||| |...|...|  ..||| . . ... .| .|..|| .|     |. .. |.|  ||  |.|.|||||||| |.|||||..
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

QALAHAYF
..|.| ||
ECLEHPYF
Kinase p38a.AA CMGC 24-308 27 4.8e-146 483.46 In-house 1-513 (513) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-513/513
Sequence Identity: 27% (144 aa)

YQNLSPVGSGAYGSVCAAFDTKTGHR--------------VAVKKLSRPFQSIIHAK----------RTYRELRLLKHMK-----------------HEN
|......|.|.|| |. ..|..|. .              ||.||...||   ..||          |..||...|||..                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGLLDVFTPA---RSLEE--------FNDVYLVTHLMGADLNNIVKCQK----------LTDDH------------VQFLI------YQILRGLK--YI
...|.|.|..    ....|        ||..|||. .|. || .. | ..          |.. |            .....      ||||||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAD--IIHRDLKPSNLAVNEDCEL--------------------KILDFGLARHTDDE------------------------MTGYVATRWYRAPEIML
||..  ||||||||.|. .|..|||                    || ||||||.....                        .| ||.|||||||||.|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NW---------MHYNQTVDIWSVGCIMAELLTG--------RTLFP-----------GTDHINQLQQIMRLTGTP----------------PAYLINRMP
.|         |||....|.||||||.||..||        ..|||           |..||.||..|... |||                .   .|. .
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------SHEARNYIQS---LAQMPKMNFANVFIG-----------------------------------ANPLAVDLLEKMLVLDS
                    |. |||||||   . . |. .. |.| .                                   ..|.|.|||.|||..| 
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DKRITAAQALAHAYF
||||||.|||.| ||
DKRITAEQALQHPYF
Kinase p38a.AA JNK 24-308 44 1.9e-126 426.35 In-house 1-309 (309) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-309/309
Sequence Identity: 44% (137 aa)

YQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRP--FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--
||||...|.|| | ||.|||. |. |||.||..||  ||   |.|| |||. ..|. .|.|.|... .|||...||||.|||.|  .| . | ...    
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWM-HYNQTVDIWSVGCIMAEL
 .|  . . .|.||...| |. ||. ||||||||||  ||.|| |||.|||.||  |    || || ||.|||||. .  |  |   ||||||||||||.
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

LTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSL---AQMPKMNFA-----NVFIG---ANPL-------AVDLLEKMLVLDSDKRIT
.... ||||.||| |  .|... ||| .  ...|. | .|||. ..    . . .||      ..| .   ..|        | ||| .||| . |.|| 
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQPH-VRNYVENRNMDPYYQPYNFHEHFPDTLFPDVMQSEPKDHLTCHMARDLLFRMLVINPDDRIS

AAQALAHAYF
  .|| | | 
VDDALQHPYI
Kinase p38a.AA ERK5 24-308 45 1.3e-116 393.67 In-house 1-295 (295) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-295/295
Sequence Identity: 45% (134 aa)

YQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKL
|. .  .| |||| ||.|   |.|..||.||.   |  .  ||||.|||..|.| .|.|.| . |.  |   . |. ||| |  || .||  |.   | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDE---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMA
| .|. . .|||||||||.|||..|||||||||| ||| ||||| |||.||      .|..   || |||||||||||.|.    | | .|.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQS-LAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
|... | .|||   |.||| ||   |.||. .|  . .   .||.|. ...    ..  |. .| . |.||| .||. .  .|||...|| | . 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase p38a.AA ERK1 24-308 50 3.1e-114 385.81 In-house 1-289 (289) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-289/289
Sequence Identity: 50% (148 aa)

YQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT
| ||. .| |||| ||.| || ...|||.||.| ||    . .|| ||...|.  ||||.|.. |.   | ..|.. |||.|  ||  ||  ..| |.| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL
 ||. . .||||||||||||| ..||||||||| .|  |.||| |||||| .| |      .| |||||||||||||||   | . .||||||||.||.|
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

TGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
  | .|||   . ||  |. . | |    .| .  . ||||.|||   ||. .| .| .| . |.|||.|||    .||||  .|||| | 
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase p38a.AA ERK7 24-308 39 3.8e-101 342.33 In-house 1-292 (292) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-292/292
Sequence Identity: 39% (117 aa)

YQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-CQK
|. .. .| |||| |  |.| .|.  ||.||    |.  . | ||.||  .|. .. |.|.| |..|.      .   |.|||   | .||.....  . 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR----ADNDRDIYLVFEFMETDLHAVIRKGNI

LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDE--------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCI
| | |.|. .||.|| .||.||...|||||||||. .. .| .|. ||||||  .. |        .| ||||||||||||.|   .| . || ||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

MAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
..|.|.|. .||||  .||. .|..... | .  |. . || | | .... | ..  . ... .. . |.||| ..||.  .||.|| |||.| | 
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase p38a.AA nmo 25-308 45 3.8e-101 311.82 In-house 2-292 (292) Show / Hide 
Range on Protein: 25-308
Range on HMM: 2-292/292
Sequence Identity: 45% (132 aa)

QNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNN-IVKCQKLT
|   |.| ||.| | .  | . |.|||.||.   ||... .|| .|||..|   ||.||. .||.  |.  .. |...| || || .||   ||  |.|.
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH-KDFFQEIYVVTELMQSDLHKIIVSPQHLS

DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG
 |||.  .|||||||||.|||.|.|||.|| || || .| ||| ||||||  . .    ||  | | .||||||..   || . ||||||||| ||||  
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

RTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYI-QSLAQMPKMNFANVFIG---ANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
| ||     |.||| |. | |||    . ..    |.. .     . |...          |.  ||.|| .||. | |||| . .|||| | 
RILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase p38a.AA S_TKc 24-308 30 2.1e-93 317.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-231/231
Sequence Identity: 30% (91 aa)

YQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA---DLNNIVKCQ
|. | ..|.||.|.|. . ..|||..||.|...         ....||...||. .|.|.. |.|||         ...|.|. ...    ||  . | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

K-------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQ-TVDIWSVGCI
.       ..  |..|..|||...|.|.||  ||||||||.|. ..|  ..|| ||||||.     | .. |.||.|||..    .|.   .|.||.|||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

MAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA-------H
..|.|.|...||      |.|..... |                                      | | |...|.|. | .||.|| .||.       |
LYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

AYF
 .|
PWF
Kinase p38a.AA Pkinase 24-308 29 1.5e-83 288.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

YQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYR--ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-----DLNNI
|. ....|||..|.|. . . .||..||||..... ..    ..  |  |....|...|.|.. |.|.|.        ...|.|. ...      ||  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

VK---CQKL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL----KILDFGLAR---HTDDEMTGYVATRWYRAPEIMLNWMHYNQTV
..     ..  ......| .|||||||.|.||  ||||||||.|. .......    || |||||.   .  ..||... |.||.|||. .   .| . |
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSVGCIMAELLTGRTLFPGT----DHINQLQQIMRLTG----TPPAYLINRMPSHEARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKR
|.||.|||..|.|.||..|||     . ..|.| | |  |     .  .........  |    .        .  . . ... . |.....| .|  ||
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------F-HWTF-HNWSEECKDFIKWCLCKDPKKR

ITAAQALAHAYF
.||.|.| | .|
PTAEQILQHPWF
Kinase p38a.AA MAPK-Unclassified 24-173 45 1.9e-67 230.41 In-house 1-157 (575) Show / Hide 
Range on Protein: 24-173
Range on HMM: 1-157/575
Sequence Identity: 45% (71 aa)

YQNLSPVGSGAYGSVCAAFDTKT-GHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLE-EFNDVYLVTHLMGA---DLNNIVK
|     .||||||.|| | |.|. .  || ||. . |.  . .||. ||.|.| .. |.|.| . |.|..   .  || |.|.|. .|     ||  | |
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

CQK--LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR
     . . |.| ..|||||||||.||| ||||||||||| .|.|| ..| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase p38a.AA MAPK-Unclassified 174-308 35 5.7e-45 155.72 In-house 400-575 (575) Show / Hide 
Range on Protein: 174-308
Range on HMM: 400-575/575
Sequence Identity: 35% (63 aa)

HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG-----------RTLFPGTD--------------------HINQLQQIMRLTGTP
|.  .||.||.|||||||||||    |   |||||.||| ||..             | ||||.|                    |. |.. |    |.|
HHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMP

PAYLINRMPSHEARNYIQSLAQMPKMNFANVFIGANP----------LAVDLLEKMLVLDSDKRITAAQALAHAYF
|   .|.  .  || ||||... . . |   .  ..|          .. |.. |||. .  ||||| ||| | ||
PEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase p38a.AA TyrKc 24-308 23 2.4e-14 9.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

YQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHM--KHENVIGLLDVFTPA--RSLEEF---NDVYLVTHLMGA-DLNN
 . .   |.||.| |. .  .     ||||.|          .  .||.|....   .|.|.. |. | |    .    |     ...|. .|   ||..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKD

IVKCQK--LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--------MT-------GY--VATRWYRAPEIMLN
  .  .  |. ..     .|| .|  |.||  .|||||   |  |.|.   || ||||.|  .|.        .        |   .  ||. ||| . |
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-N

WMHYNQTVDIWSVGCIMAELLT-GRTLFPG--------TDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLAQMPKMNFANVFIGANPLAVDLLEK
   ..   |.|| |  | |..| | .  ||        .. |....| .|.   | .|    |                       | .. .   .. ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS----------------------FVCCPDEMYQIMKQ

MLVLDSDKRITAAQALAHAYF
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CWHEDPEDRPTFSEI--HECF
Kinase p38a.AA Pkinase_Tyr 24-87 23 0.000704 13.76 Pfam 1-70 (270) Show / Hide 
Range on Protein: 24-87
Range on HMM: 1-70/270
Sequence Identity: 23% (17 aa)

YQNLSPVGSGAYGSVCAAFDT----KTGHRVAVKKLSRPFQSIIH--AKRTYRELRLLKHM-KHENVIGLL
 . .   |.||.|.|. .  .    .|.  ||||.| ..  .  .   .   ||....|.. .|.|.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase p38a.AA Pkinase_Tyr 132-221 35 0.019835 8.85 Pfam 118-213 (270) Show / Hide 
Range on Protein: 132-221
Range on HMM: 118-213/270
Sequence Identity: 35% (35 aa)

YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVAT-------RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRT
.|| .|. | .|  .|||||   |  |.|.   || ||||||   .|.   |...       .|. ||| . .   ..   |.|| |  | |..| |..
WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFTYGEQ