Gene p38g (Mouse)

p38g

Species: Mouse
Alias: p38g, Mapk12
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
p38g.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON
p38g.AA Protein Sugen 367 None Fasta, JSON
p38g.NA RNA Sugen 1553 None Fasta, JSON

Protein domain

Protein domains of p38g.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase p38g.AA p38 27-311 69 2.8e-226 758.03 In-house 1-289 (289) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-289/289
Sequence Identity: 69% (200 aa)

YQDLQPVGSGAYGAVCSAVDSRTGNK---VAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTP-DESLDDFTDFYLVMPFMGTDLGKLMKH
||.||||||||||.||.|.|.|||.|   ||||||.||||||..|||.||||||||||||||||.||||||| ..|..||.|.|.|..|||.|| ..||.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

ETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG
..||.|.|||||||.|.||||||.||.|||||||.|.||||||||.||||||||..|.||||||.||||||||..||||.||||||||||||||||.|||
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITG

KILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLERMLVLDAEQRVTAAEALTHPYF
..||.|.||.|||..|||..|||..||.||.|| ||.||....|.....||..|...|.|||..|||.||.||...|.||.||..||||
RTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase p38g.AA MAPK 27-311 51 1.2e-195 656.31 In-house 1-328 (328) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-328/328
Sequence Identity: 51% (169 aa)

YQDLQPVGSGAYGAVCSAVDSR------TGNKVAIKKLYRPFQSELFAKRAYRELRLLKHM-RHENVIGLLDVFTPD-----ESLDDFTDFYLVMPFMGT
||.|.|.|.|||| ||||.| |      .|.||||||. ||||.....||.|||..||.|. .|||.|.|||.|||.     .||..| |.|.||..|.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLGKLMKHET-LSEDRIQFLVYQMLKG--LKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSE-----------------MTGYVVTRWYRAP
|| ...| .  ||.|.||...||.|.|  ||||| |.||||||||.|..|||.|.|||.||||||..|.|                 ||.||.|||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILN--WMRYTQTVDIWSVGCIMAEMIT-GKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQ-SAEAKNYMEGL---PELEKKDFASVLTN----ASPQ
|..||  ||.||..||.||||||.|||.| .|.||.|.|..||.. ||...|||..||.|... | .|.|| ..|   |   ||...... |    |.||
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AVNLLERMLVLDAEQRVTAAEALTHPYF
|..|||.|||.| ..| |..||| ||||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase p38g.AA ERK 27-311 46 1.2e-146 493.43 In-house 1-307 (307) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-307/307
Sequence Identity: 46% (142 aa)

YQDLQPVGSGAYGAVCSAVDSR-----TGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLM
||.....| |||| ||||.|       ||.||||||  ..|  ....||..||..||.| . |||.|.|.|.. |. .  .. | |.| ..| ||| .  
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE-QYNDIYCVEELMETDLHQII

KHE-TLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLAR----QADSE-------MTGYVVTRWYRAPEVILNWMRYTQTVD
. . .||.| .|...||.| |||||| |.||||||||.|. ||..| ||| ||||||     ...        ||.||.||||||||..|.|  ||. .|
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

IWSVGCIMAEMITGKILFKGNDHLDQLKEIMKITGTP-PPEFVQKLQSAEAKNYMEGLPE--LEKKDFASVLTNAS--PQAVNLLERMLVLDAEQRVTAA
|||.|||.|||. .| ||.|.|...|. .| .|.||| . | .|. .| .|..|   ||.   ..|.. ..  ||.  |||..|||.||| | ..| |..
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

EALTHPYF
|.| ||||
ECLEHPYF
Kinase p38g.AA CMGC 27-311 26 1.4e-141 468.46 In-house 1-513 (513) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-513/513
Sequence Identity: 26% (139 aa)

YQDLQPVGSGAYGAVCSAVDSRTG--------------NKVAIKKLYRPFQSELFAK----------RAYRELRLLKHMR-----------------HEN
|. ....|.|.|| |....| ||.              ..|||||. .||  |  ||          ||.||...|||..                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGLLDVFTPDES------------LDDFTDFYLVMPFMGTDLGKLMKHET----------LSEDR------------IQFLV------YQMLKGLK--Y
...|.|.|....|            . .| ..|||. .|..|| ...|.            |||              |....      ||.|.|||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHAAG--VIHRDLKPGNLAVNEDCEL--------------------KILDFGLARQADSE------------------------MTGYVVTRWYRAPEVI
.| ..  .||||||| |. .|..|||                    || ||||||. ...                        .| |||||||||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNW---------MRYTQTVDIWSVGCIMAEMITG--------KILFK-----------GNDHLDQLKEIMKITGTPPPEFVQK----------LQ-----
|.|         | ||...|.||||||.|||.||        |.||.           |..|.|||..|.|. |||. .. ||           .     
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

----------------------SAEAKNYMEG---LPELEKKDFASVLTN-----------------------------------ASPQAVNLLERMLVL
                      |  |.|| .    .|.  .|.. ..  .                                   ..|||..||..||..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DAEQRVTAAEALTHPYF
| ..| ||..|| ||||
DPDKRITAEQALQHPYF
Kinase p38g.AA JNK 27-266 48 3.1e-120 405.73 In-house 1-249 (309) Show / Hide 
Range on Protein: 27-266
Range on HMM: 1-249/309
Sequence Identity: 48% (122 aa)

YQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRP--FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLMKH--
|| |...|.|| | ||.| |  |. .|||||. ||  ||    .||||||. ..|.  |.|.|... .|||.|.|..|.|.|.|| .|   |  .     
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

ETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNWM-RYTQTVDIWSVGCIMAEM
. |  .|. .|.|||. | |. |..|.||||||| |  ||.|| |||.|||.|| .|    || |||||.|||||||.  |  |.  |||||||||||||
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

ITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKNYMEGL---P
|....||.| || ||   |..  ||| |.| ...|   ..||.|..   |
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQPH-VRNYVENRNMDP
Kinase p38g.AA ERK5 27-311 42 3.7e-105 355.67 In-house 1-295 (295) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-295/295
Sequence Identity: 42% (126 aa)

YQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLMKHET-L
|. .  .| |||| ||||.  ..|..|||||.   |     ||| .|||..|.| ||.|.| . |.  | . . .. | | |.  |  || ...  .  .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADS--------EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMA
. . | . .||.|.||||.|.| |||||||| || ||| ||||| |||.||             || || ||||||||...    ||| .|.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKNYMEG-LPELEKKDFASVLTNASPQAVNLLERMLVLDAEQRVTAAEALTHPYF
|||. . .| |   ..||. ||.. |.|||  .|   .   .||.   .|. . ||.  |   | .||..|| |||. .  .|.|...|| ||. 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase p38g.AA ERK1 27-311 45 1.1e-104 354.04 In-house 1-289 (289) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-289/289
Sequence Identity: 45% (133 aa)

YQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLMKHETLS
| .|| .| |||| ||||.| .....|||||.  ||    . .|  ||...|.  .|||.|.. |.   | ... . | |.|   | ||| ||.|   ||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRAD-TIEQMRDVYIVQCLMETDLYKLLKTQHLS

EDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMI
 | | . .||.|.||||||.| |.|||||| || .|  |.||| |||||| || |      .| || ||||||||..||   ||. .||||||||.|||.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

TGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLERMLVLDAEQRVTAAEALTHPYF
  . .| |   ||||  |. . | |  . .. .    |.||...||  .|  .|..  .| ..|. ||..||    ..|.|  ||| ||| 
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase p38g.AA S_TKc 27-311 30 9.8e-99 335.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-231/231
Sequence Identity: 30% (92 aa)

YQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLDDFTDFYLVMPFMGT---DLGKLMKHE
|. |...|.||.| |. ... .|| .||||..          ....||...||. .|.|.. |.|||         ...|.|| ....   || ...|. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

T-------LSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQ-TVDIWSVGCI
        ..| ...|..||....|.|.|  |.||||||| |. ..|  ..|| |||||||     | ...|.||.||||.     |.   .|.||.|||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

MAEMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLERMLVLDAEQRVTAAEALT-------H
..||..|. .|       |.....|. |                                     ||.| ......|. | |.| || |||.       |
LYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PYF
|.|
PWF
Kinase p38g.AA ERK7 27-311 37 4.1e-97 328.92 In-house 1-292 (292) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-292/292
Sequence Identity: 37% (112 aa)

YQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLMK-HET
|. .. .| |||| |  |.| ||.. ||.|| .  |. .  | | .||  .|. .. |.|.| |..|.  |  .    |.|||  || |||    .  . 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDR----DIYLVFEFMETDLHAVIRKGNI

LSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLAR---------QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCI
| .   |. .||.|. .||.| . |||||||| |. .. .| .|. ||||||         ...  .| || ||||||||. |   |||. || ||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

MAEMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLERMLVLDAEQRVTAAEALTHPYF
..||..|| .| |.  ..|.  |..... |  | .. ..|  | | .| ... ..| .  ........|..|| |.||.  ..|.|| .|| ||| 
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase p38g.AA CDK 27-311 34 1e-92 296.95 In-house 1-284 (284) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-284/284
Sequence Identity: 34% (111 aa)

YQDLQPVGSGAYGAVCSAVDSRTG-----NKVAIKKLYRPFQ-----SELFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLDDF-----TDFYLVMPF
|. |. .| |.|| |  | | .||     . ||.||.    .      | |   | ||  |||.. |.|.. |.||.. ... ...     . .|.|...
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MGTDLGKLMKHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCE-----LKILDFGLARQA---------DSEMTGYVVTRWYRAPEVI
| .|| |.|.        |. . .|.|.|| |.|  ...|||||| |. .|.. |     ||| ||||||             ..|  |||.||||||. 
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

LNWMRYT--QTVDIWSVGCIMAEMIT---GKILFKGNDHLDQLKEIMKITGTPPPEF---VQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLE
|   .|.   ..|.||||||.|||.|   .| || |.  .|||. | .| ||| ..    | ||.                               .||.
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------------DLLN

RMLVLDAEQRVTAAEALTHPYF
.||..| ..|..| .|| ||||
KMLCYDPKKRISAEQALQHPYF
Kinase p38g.AA Pkinase 27-311 29 3.2e-92 317.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-293/293
Sequence Identity: 29% (93 aa)

YQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYR--ELRLLKHMRHENVIGLLDVFTPDESLDDFTDFYLVMPFMGT-----DLGKL
|. ....|||..| |. ...  || .||.|.. .. ... . ... |  |....|...|.|.. |.|.|.        .. |.||....      ||  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

MK---HETL--SEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCEL----KILDFGLARQ---ADSEMTGYVVTRWYRAPEVILNWMRYTQTV
..   | ..  ||. ..| .||.|.||.|.|. |.||||||| |. .......    || |||||.|    .| ||....|.||.|||||.    |.. |
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSVGCIMAEMITGKILFKGN----DHLDQLKEIMKITGTPPPEFVQKL--------QSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLERMLVLD
|.||.|||..||..|. .|.|     . .||.. | .| |.|...  ...        .  . .           . .  . .|.|. .  .....| .|
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H-----------F-HWTF-HNWSEECKDFIKWCLCKD

AEQRVTAAEALTHPYF
 ..| ||...| ||.|
PKKRPTAEQILQHPWF
Kinase p38g.AA MAPK-Unclassified 27-176 42 4e-66 225.98 In-house 1-157 (575) Show / Hide 
Range on Protein: 27-176
Range on HMM: 1-157/575
Sequence Identity: 42% (67 aa)

YQDLQPVGSGAYGAVCSAVDSRT-GNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLD-DFTDFYLVMPFMGT---DLGKLMK
|   . .|||||| || |.|... . .|||||. . |. .  .||. ||.|.| .. |.|.| . |.|...| .  .| | |.|| .| |   || .. |
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

HET--LSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLAR
     ...  || . || |.||||.|.|..||||||| || .|.|| ..| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase p38g.AA MAPK-Unclassified 181-311 31 2.6e-40 140.24 In-house 404-575 (575) Show / Hide 
Range on Protein: 181-311
Range on HMM: 404-575/575
Sequence Identity: 31% (54 aa)

EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG-----------KILFKGND--------------------HLDQLKEIMKITGTPPPEF
.||.||||||||||| .|    |.  |||||.||| |||.             ..||.| |                    | ||.| |    |.|| | 
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

VQKLQSAEAKNYMEGLPELEKKDFASVLTNASP----------QAVNLLERMLVLDAEQRVTAAEALTHPYF
 .  ... |. | ...      .| .    . |          .. ...  ||. ..  | || .|| ||||
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase p38g.AA TyrKc 27-311 22 4e-14 5.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-311
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

YQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHM--RHENVIGLLDVFTPDESLDDF---TDFYLVMPFM-GTDLGKLM
 . ..  |.||.| |. .. .    .||.|.|          .  .||.|....   .|.|.. |. | | ..    |      ..|| .| . || .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYL

-KHET-LSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSE-----MTGYVV------TR------WYRAPEVILNWM
 ||.  |. .      .|  .|  |.|  ..|||||   |  |.|.   || ||||.|  ...      . | .      ..      |. |||.| |  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYG

RYTQTVDIWSVGCIMAEMITGKILFKGN-----DHLDQLKEIMKITGTPPPEFV----QKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLERML
..|   |.|| |  | |. |       .        ... |  |  . .|.                             |      ...   .. ..  
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------F----VCCPDEMYQIMKQCW

VLDAEQRVTAAEALTHPYF
  |.|.| | .|   | .|
HEDPEDRPTFSEI--HECF
Kinase p38g.AA JNK 283-311 44 6.8e-08 25.5 In-house 281-309 (309) Show / Hide 
Range on Protein: 283-311
Range on HMM: 281-309/309
Sequence Identity: 44% (13 aa)

QAVNLLERMLVLDAEQRVTAAEALTHPYF
.| .|| |||| . ..|    .|| ||| 
MARDLLFRMLVINPDDRISVDDALQHPYI
Kinase p38g.AA Pkinase_Tyr 139-221 36 0.000223 15.45 Pfam 122-209 (270) Show / Hide 
Range on Protein: 139-221
Range on HMM: 122-209/270
Sequence Identity: 36% (33 aa)

KGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVT-------RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT
||. | .. . |||||   |  |.|.   || ||||||   . .   |...       .|. |||.| .   .|   |.|| |  | |..|
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFT
Kinase p38g.AA Pkinase_Tyr 27-112 25 0.000875 13.44 Pfam 1-89 (270) Show / Hide 
Range on Protein: 27-112
Range on HMM: 1-89/270
Sequence Identity: 25% (24 aa)

YQDLQPVGSGAYGAVCSAVDS----RTGNKVAIKKLYRPFQSEL-FAKRAYRELRLLKHM-RHENVIGLLDVFT-PDE-SLDDFTDFYLVMPFM
 . ..  |.||.| |. ..       |. .||.|.|     .|  . .   ||....|.. .|.|.. |. | |  .| .       |.||..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYM