Gene C09D4.3 (Nematode worm)

C09D4.3

Species: Nematode worm
Alias: CE27672, aSWK133, C09D4.3
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 5488358-5490566, WormBase Genetic Map location: I:0.09,

Classification

Group: CK1
Family: Worm6

Sequence

Name Sequence Type Origin Length Description Download
C09D4.3.AA Protein Genbank 406 None Fasta, JSON
C09D4.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 272 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of C09D4.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C09D4.3.AA Worm6 88-346 39 2.7e-142 479.05 In-house 1-279 (279) Show / Hide 
Range on Protein: 88-346
Range on HMM: 1-279/279
Sequence Identity: 39% (110 aa)

FILRQKLGDGAMGHVFLSIF--GGR--SVAIKAEK----YSTGMLPMEIKVLLSIRRHNGVHFCDIIDYGTIRRE-YNYMIISILGKDLYRLRAEQPTRS
. ...|.|.|..|.|...    ...   .|.|.||    ....||.||. ||. ...|.. |||.|.|.|..... .||... ..||.|..||...|.| 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FTLNTTTKIALETIEAIEELHNIGYLSRDVKPSNFAPGQ---RDNGQHKTIFMFDFGLAK--KFIDRDNKKLKSR-GEVGWRGTVRYGSLQAHKRMDLGR
|...|. |||....||||.|||.|...|||||.||..|.   .....|.||.|.|||...  |.....|.  . |  ..|.||||||..|..||.....|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDVECWFYMLIEMLVGELPWRHMSDRTLVGQSKLSIRNESR----RLFFNRTPR-QFETIMDMIDGYSFEIRPEYRHL
.||.|.||||..||.||.||||||.|.  |.. |  .|.. |    |.||...|. .|. |||.||.||.. ||.|...
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase C09D4.3.AA CK1 88-346 26 2.8e-95 322.84 In-house 1-339 (339) Show / Hide 
Range on Protein: 88-346
Range on HMM: 1-339/339
Sequence Identity: 26% (90 aa)

FILRQKLGDGAMG-HVFLS-----IFGGRS-------VAIKAEKYSTG---MLPMEIKVLLSIRRHN---------GVHFCD----------IIDYGTIR
. . .|.|.|. | ....      .   ..       .|.|.|. ..    .. ||  ... . ...         . |||.          ....|   
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

REYNYMIISILGKDLYRLRA--EQPTRSFTLNTTTKIALETIEAIEELHNIGYLSRDVKPSNFAPGQRD-----------NGQHKTIFMFDFGLAK-KFI
. ||||... ||..| .||.   ...| |...|. .||. ..||.|..|..|.. ||.||.||. |  .           |..|....|.|||.|. |..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DRDNKK------------LKSRG---EVGWRG-TVRYGSLQAHKRMDLGRRDDVECWFYMLIEMLVGE--LPWRHMSDRTL-----VGQSKLSIRNE---
|.|...               |     .|.|| |.|| |. .|.....|||||...|||||||.|.|.  |||..|.| .      |.. |  ...|   
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

SRRLFFNRTPR-------QFETIMDMIDGYSFEIRPEYRHL
|...|  ..|.       .| .||..|...... ||.|  .
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase C09D4.3.AA TTBKL 88-350 26 2.2e-60 202.57 In-house 1-288 (288) Show / Hide 
Range on Protein: 88-350
Range on HMM: 1-288/288
Sequence Identity: 26% (77 aa)

FILRQKLGDGAMGHVF--LSIFG-GRSVAIKAEKYS-TGM---LPMEIKVLLSIRRHNGVHFCDIIDYGTIRREYNYMIISILGKDLYRLRAEQPTRS-F
.   ...| |..| |.   .. . .   | |.||..  |.   . ||..||.    ..  ||. ....| . . ||.|. . .|..|  ||.  |..  |
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKD-YNFMVMTLCGPNLQDLRKMMPNKKRF

TLNTTTKIALETIEAIEELHNIGYLSRDVKPSNFAPGQRDN-GQH-KTIFMFDFGLAKKFIDRDN-------------KKLKS-RGEVGWRGTVRYGSLQ
.  |.  |.  ...|. ..| .|.. |||||.|.. |  |. .   .... .|||.|..... |.             .. .. |. .. |||.|| |. 
SDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPN

AHKRMDLGRRDDVECWFYMLIEMLVGELPWRHMSDRTLVGQSKLSIRNESRRLFFNR-----TPRQFETIMDMIDGYSFEIRPEYRHLKALI
.| |...|| ||  .|.||.||...| |||..|.|.  ... |..   |  .|| .       |..|. .| ..   ..  || |  . ...
MHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDE--DLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase C09D4.3.AA TTBK 90-346 35 2.4e-54 186.87 In-house 3-257 (257) Show / Hide 
Range on Protein: 90-346
Range on HMM: 3-257/257
Sequence Identity: 35% (92 aa)

LRQKLGDGAMGHVF--LSIFGG-RSVAIKAEKYSTG--MLPMEIKVLLSIRRHNGVHFCDIIDYGTIRREYNYMIISILGKDLYRLRAEQPTRSFTLNTT
  .| | |. | ..  . .      |||| |.  .    | ||. ||      .  | |  |  |   . .|||. ...|| |  || .||   |.| ||
VVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCD--HVCRFIGCGRNDK-FNYMVMQLQGKNLADLRRKQPRGCFSLSTT

TKIALETIEAIEELHNIGYLSRDVKPSNFAPGQRDNGQHKTIFMFDFGLAKKFIDRDNKKLKSRGEVGWRGTVRYGSLQAHKRMDLGRRDDVECWFYMLI
 .. .  ...||. |..|.| ||.|||||| | |   . . ..| ||||| ...         |   | |||||| |  ||.  ..||.||    ||||.
LRLGVQILQSIESIHSVGFLHRDIKPSNFAMG-RNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLV

EMLVGELPWRHMSDRTLVGQSKLSIRNESRRLFFNRTPRQFETIMDMIDGYSFEIRPEYRHL
| ..| |||| . |.  ||. |        |.  .  | .|.. || |    .| ||.|  .
EFVQGQLPWRKIKDKDQVGEMK---EKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase C09D4.3.AA Dual 141-350 27 9.4e-39 127.86 In-house 71-282 (282) Show / Hide 
Range on Protein: 141-350
Range on HMM: 71-282/282
Sequence Identity: 27% (59 aa)

HFCDIIDYGTIRRE-YNYMIISILGKDLYRLRAEQPTRSFTLNTTTKIALETIEAIEELHNIGYLSRDVKPSNFAPGQRDNGQHKTIFMFDFGLAKKFID
.| . .||| .     .|...|  |  |   |      ...  .   .|. ...||  ||.|||| |..||.||. |   . .  |..| ||....|.||
CFIEFVDYGKCEQDKCKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGL--GMDETTVYMQDFRIVRKYID

RDNKKLK-SRGEVGWRGTVRYGSLQAHKRMDLGRRDDVECWFYMLIEML-VGE-LPWRHMSDRTLVGQSKLSIRNESRRLFFNRTPRQFETIMDMIDGYS
  ||| .  |  |   |. || .    .  | || ||.||| ||.  ..  .  ..||   |.  . ..|           . ..||..  . ....||.
PENKKHRTARKKVKMYGCGRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQ

FEIRPEYRHLKALI
..  |.|  .   .
YDSTPDYDYFRNCL
Kinase C09D4.3.AA CK1-Unclassified 88-293 32 1e-28 81.92 In-house 1-216 (244) Show / Hide 
Range on Protein: 88-293
Range on HMM: 1-216/244
Sequence Identity: 32% (71 aa)

FILRQKLGDGAMGHVFLSIFG--GRSVAIKAEKYST--GMLPMEIKVLLSIRRHNGV-----HFCDIIDYGTI-RREYNYMIISILGKDLYRLRAEQPTR
. . .|.| |. | ... |    .. |||| ||  .   .|. |.|..   ...  .     ..  .. .|.   ..||.|. . ||..|  |      |
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNMCNR

SFTLNTTTKIALETIEAIEELHNIGYLSRDVKPSNFAPGQRDNGQHKTIFMFDFGLAKKFI--DRDNKKLKSRGEVGWRGTVRYGSLQAHKRMDLGRRDD
 |.| |.  ||   |. || ||| ... || || ||  |.  ...|..... ||||.|..|  |...|    | . .. || || |..||. .  .||||
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGK-LGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDD

VECWFYMLIEMLVGELPW
 |   | ||  | |.|||
LESLGYVLIYFLKGSLPW
Kinase C09D4.3.AA CK1-A 88-346 32 1.6e-26 90.67 In-house 1-261 (261) Show / Hide 
Range on Protein: 88-346
Range on HMM: 1-261/261
Sequence Identity: 32% (86 aa)

FILRQKLGDGAMGHVFL--SIFGGRSVAIKAEKYSTGM--LPMEIKVLLSIRRHNGVHFCDIIDYGTIRREYNYMIISILGKDLYRLRAEQPTRSFTLNT
. | .|.| |. | ..|  .|  |  |||| |.       |  | ||   ...  .| .  .  ||.  ..|| |.. .||  |  |     .| ||. |
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQG--CVGIPHMRWYGC-EKDYNVMVMDLLGPSLEDL-FNFCKRRFTMKT

TTKIALETIEAIEELHNIGYLSRDVKPSNFAPGQRDNGQH-KTIFMFDFGLAKKFID-RDNKKLKSRGEVGWRGTVRYGSLQAHKRMDLGRRDDVECWFY
   .|   |  || .|. ... ||.|| ||  |    | |   .|. |||||||. | |  . .. | .    ||.|| |..||  ..  ||||.|   |
VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI---GRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGY

MLIEMLVGELPWRHMSDRTLVGQ-SKLSIRNESRRL--FFNRTPRQFETIMDMIDGYSFEIRPEYRHL
...    |.|||  |   |   .  |.| .  |  .       | .|  .|  . .  ||  |.| .|
VMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase C09D4.3.AA CK1 88-293 31 4.5e-26 86.87 In-house 1-216 (271) Show / Hide 
Range on Protein: 88-293
Range on HMM: 1-216/271
Sequence Identity: 31% (68 aa)

FILRQKLGDGAMGHVFLSIFGGR---S--VAIKAEKYSTG--MLPMEIKVLLSIRRH----NGVHFCDIIDYGTI-RREYNYMIISILGKDLYRLRAEQP
. . .|.| |. | ..| |          |||| ||  .   .|. |.|..   ..|     ....  .. .|.   ..||.|... ||..|  |     
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNFC

TRSFTLNTTTKIALETIEAIEELHNIGYLSRDVKPSNFAPGQRDNGQHKTIFMFDFGLAKKFID-RDNKKLKSRGEVGWRGTVRYGSLQAHKRMDLGRRD
 | |.| |.  ||   |. || .|| ... ||.|| ||  |   . ....... ||||||...| ....    |   .. ||.|| |...|  .  .|||
NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRD

DVECWFYMLIEMLVGELPW
| |   |.|.  | |.|||
DMESLGYVLMYFLRGSLPW
Kinase C09D4.3.AA CK1-D 88-346 27 4e-25 85.48 In-house 1-261 (261) Show / Hide 
Range on Protein: 88-346
Range on HMM: 1-261/261
Sequence Identity: 27% (74 aa)

FILRQKLGDGAMGHVFL--SIFGGRSVAIKAEKYSTGMLPMEIKVLLSIRRHNGVHFCDIIDYGTIRREYNYMIISILGKDLYRLRAEQPTRSFTLNTTT
. .  |.| |. | ...   |  .  |||| |   |    ..|   .    . |.    |  .|    .|| |.. .||  |  |      | | | |  
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCG-QEGDYNVMVMDLLGPSLEDL-FNYCHRKFSLKTVL

KIALETIEAIEELHNIGYLSRDVKPSNFAPGQRDNGQHKTIFMFDFGLAKKFIDRD-NKKLKSRGEVGWRGTVRYGSLQAHKRMDLGRRDDVECWFYMLI
 .|.  |  || .|   .. ||.|| ||  |    |.  .... ||||||.. |    . .  | .    || || |.  |. ..  ||||.|   |.|.
MLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGN--MVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLM

EMLVGELPWRHMSDRT------LVGQSKLSIRNESRRLFFNRTPRQFETIMDMIDGYSFEIRPEYRHL
    | |||  .   |       . . |.|.. .      .  | .|.. |.      |. .|.| .|
YFNRGSLPWQGLKAATKRQKYERICEKKMSTKID---TLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase C09D4.3.AA CK1-Unique 141-294 24 5.3e-22 73.09 In-house 71-233 (337) Show / Hide 
Range on Protein: 141-294
Range on HMM: 71-233/337
Sequence Identity: 24% (40 aa)

HFCDIIDYGTIRREYNYMIISILGKDLYRLRAEQPTR-SFTLN------TTTKIALETIEAIEELHNIGYLSRDVKPSNFAPGQRDNGQHKTIFMFDFGL
||| ..| .   | . ...  ..|. .  .. . . . .||||      .  . .. . ..||  |  |.. |. || |.  .       ....| |.| 
HFCEVHDFH-QHRDWWWIVMTMHGPSMEECC-MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGI

AKK--FIDRDNKKLKSRGEVGWRGTVRYGSLQAHKRMDLGRRDDVECWFYMLIEMLVGE--LPWR
 ..  |..  .   . |  .  ||. .| .   |.  ..||||| | |||||.  . ..  | |.
CRRVFFVSNNHQIRQPRPITPFRGCKDYCPCSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase C09D4.3.AA S_TKc 88-369 15 7e-11 -17.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 88-369
Range on HMM: 1-231/231
Sequence Identity: 15% (50 aa)

FILRQKLGDGAMGHVFLSIFGG--RSVAIKAEKYSTGMLPMEIKVLLSIRRHNGVHFCDIIDYGTIRREYNYMIISILGK---DLYRLRAEQPT----RS
. . .|.| ||.| |.. .  .  | ||||  |    ..  ||..| . .  | |.. |...      .. ||.   ..    ||...  ....    . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FTLNTTTKIALETIEAIEELHNIGYLSRDVKPSNFAPGQRDNGQHKTIFMFDFGLAKKFIDRDNKKLKSRGEVGWRGTVRYGSLQAHKRMDLGRRDDVEC
|.  .. ... ....|.| .|. | . ||.||.|    .       .|   |||||...                 ||  | .                 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL-------------

WFYM-----------LIEMLVGELPWRHMSDRTLVGQSKLSIRNESRRLFFNRTPRQFETIMDMIDGYSFEIRPEYRHLKALINEIRMENMI----PDRC
 .             |.|||.|. |..     ..    |.                                    . .| .|. .   .         .
GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EA

KW-------DWQV
         .  .
LQDEWDIKCHPWF
Kinase C09D4.3.AA Pkinase 88-213 20 7e-06 21.8 Pfam 1-139 (293) Show / Hide 
Range on Protein: 88-213
Range on HMM: 1-139/293
Sequence Identity: 20% (29 aa)

FILRQKLGDGAMGHVFLSIFGGRS--VAIKAEKYSTGMLPM--------EIKVLLSIRRH-NGVHFCDIIDYGTIRREYNYMIISILGK-----DLY-RL
. . .|.| |..| |.. .  | .  ||.|  |...    .        ||...... .| | | . |.  .    . . ||.   ...     ||. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYI

R--AEQPTRSFTLNTTTKIALETIEAIEELHNIGYLSRDVKPSNF
.  .. .   |. ..  ..........| .|. | . ||.||.|.
STWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI
Kinase C09D4.3.AA TyrKc 88-350 18 0.000105 -146.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 88-350
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

FILRQKLGDGAMGHVFLSIFGGRSVAIKAEK--YSTGMLPMEIKVLLSI-RRHNGVHFCDIIDYGTIRRE-------YNYMIISILGKD---LYRLRAEQ
  | .||| || | |.. .   . ||.|  |      ..  |.... ..  .|  .    .  || .. .         .||.  . .    . .||. .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNI----VRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

PTRSFTLNTTTKIALETIEAIEELHNIGYLSRDVKPSNFAPGQRDNGQHKTIFMFDFGLAKKFIDRD-----NKKLKSRGE--VGWR-GTVRYGSLQAHK
|.  ... .  ....   .  | ||  ..  ||    |   | .      |.   ||||. ..|. |     .|. ..  |   |     .|  ..    
PK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP----

RMDLGRRDDVECWFYM--------------LIEML-VGELPWRH-----MSDRTLVGQSKLSIRNESRRL-----FFNRTPRQFETIMDMIDGYSFEIRP
          ||..|               . |..  |. |.       ||.. .. . |   | .         |  . |    .|| .   .  | ||
----------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRP

EYRHLKALI
  . .. ..
TFSEIHECF