Gene C27D8.1 (Nematode worm)

C27D8.1

Species: Nematode worm
Alias: aSWK137, C27D8.1, CE18539
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 12717865-12719368, WormBase Genetic Map location: No interpolated position.,

Classification

Group: CK1
Family: Worm6

Sequence

Name Sequence Type Origin Length Description Download
C27D8.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON
C27D8.1.AA Protein Genbank 327 None Fasta, JSON

Protein domain

Protein domains of C27D8.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C27D8.1.AA Worm6 24-288 49 1.2e-160 540.0 In-house 1-279 (279) Show / Hide 
Range on Protein: 24-288
Range on HMM: 1-279/279
Sequence Identity: 49% (139 aa)

YTVVRLLGEGGFGAVYLVQDNKSKK--QSAMKVERKIEKRKHSKLKMEIAILKLVGSGK--HFTQIVDRGKKDKEGFFFLVMELVGKSLADLKADRPDKV
..|....|||||||||.|.| . ||  | |||.|...|..|...||||...||.|. .|  ||..|.||||.|..||...||.||||.|.||...|||. 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSFATGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGL-----DEKRHNIYILDFGIAR--KYLNTKNELKTPR-ETVGFKGTVRFAPIACHRNTEMGP
||..|||....|||||.|.||..||||||.||.|...|      |...|.||.||||..|  ||.|..|||.||| ...||.||||.||.|||...|...
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

KDDCESWFYLLLDLIVPSGLPWRKLSDKHEVLKEKEECRKDKR---SSLFAGLRQTDYLSKVLDYIDGRAYQDRVDYQFI
|||||||||.....||. .||||...|...| |.|..||...|    ..| |  ... .....||||...|.||.||.||
KDDCESWFYMMVEMIVG-CLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase C27D8.1.AA CK1 24-288 28 1.2e-108 367.22 In-house 1-339 (339) Show / Hide 
Range on Protein: 24-288
Range on HMM: 1-339/339
Sequence Identity: 28% (98 aa)

YTVVRLLGEGGFG-AVYLV-----QDNKSK-----KQSAMKVERKIEKRKHSKLKMEIAILKL-------------------VGSGKHFTQIVDRGKKDK
..||...|||||| ..|.|      | |..     .. |||||.| .. .|..|..|. ..|.                   . .|...  ... .....
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

EGFFFLVMELVGKSLADLKA-DRP-DKVFSFATGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGL-------------DEKRHNIYILDFGIAR-KYL
... ..||.|.|..| ||.. .|. .. ||  |.| . .|.|||.|..|  ||||||.||.|...|.             .......|..|||.|| ||.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

N------------TKNELKTPRE---TVGFKG-TVRFAPIACHRNTEMGPKDDCESWFYLLLDLIVPS-GLPWRKLSDKHE-----VLKEKEECRKD--K
.             ......|||   ..|| | |.|...|.||.. |.|..||..||||.|....... ||||....|. .     | |.|.|....  .
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

RSSLFAGLRQTD------YLSKVLDYIDGRAYQDRVDYQFI
  ..| .   ..      .. |...||..  |.|| ||..|
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase C27D8.1.AA TTBKL 24-292 32 1.9e-72 243.92 In-house 1-288 (288) Show / Hide 
Range on Protein: 24-292
Range on HMM: 1-288/288
Sequence Identity: 32% (96 aa)

YTVVRLLGEGGFGAVYLVQDNKSKKQ-SAMKVERKIEKRKHSKLKMEIAILKLVG--SGKHFTQIVDRGKKDKEGFFFLVMELVGKSLADLKADRPDK-V
...|...||||||.||.| | |.||.  |||.| . . .. |..|||. .|..    . .|| .... ||...  . |.||.|.|..| ||... | | .
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKD--YNFMVMTLCGPNLQDLRKMMPNKKR

FSFATGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGLDEK----RHNIYILDFGIARKYLNTKNEL-----------KTPRE---TVGFKGTVRFAPI
||  | . .. |||.|. ..|  ||||||.||.|.. |. ..    ....|..|||.||.|..  .|.           ..||.   ...| ||.|.. .
FSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSP

ACHRNTEMGPKDDCESWFYLLLDLIVPSGLPWRKLSDKHEVLKEKEECRKDKRSSLFAGLR----QTDYLSKVLDYIDGRAYQDRVDYQFIYKNL
. |.  | |..||  ||.| .  | ..  |||. ..||.|. . |...   |   || ..      .... |.  ..    |.|| ||. ||. .
NMHDRKEQGRHDDLWSWMYMIIELHCG--LPWTNMEDKMEIEHMKKNM---KDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase C27D8.1.AA TTBK 24-288 40 4.7e-65 222.44 In-house 1-257 (257) Show / Hide 
Range on Protein: 24-288
Range on HMM: 1-257/257
Sequence Identity: 40% (107 aa)

YTVVRLLGEGGFGAVYLVQDNKSK-KQSAMKVERKIEKRKHSKLKMEIAILKLVGSGKHFTQIVDRGKKDKEGFFFLVMELVGKSLADLKADRPDKVFSF
 .||.  | |||| .|  .|   .  | |.|||    ..    ||||.|.||     .|  . .  |  ||  | ..||.| ||.||||    |.  || 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQV--LKMEVAVLKKLQGCDHVCRFIGCGRNDK--FNYMVMQLQGKNLADLRRKQPRGCFSL

ATGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGLD-EKRHNIYILDFGIARKYLNTKNELKTPRETVGFKGTVRFAPIACHRNTEMGPKDDCESWFYL
 | | .  | |...|. |  || ||| || |.| |.  ... ..|.|||| ||.|.|.. |  .|||  || ||||.| |  ||| ||| .||  | ||.
STTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYM

LLDLIVPSGLPWRKLSDKHEVLKEKEECRKDKRSSLFAGLRQTDYLSKVLDYIDGRAYQDRVDYQFI
|   ..   |||||. || .| . ||.        |   . .   ..  .| |    |.|| |||.|
LVEFVQ-GQLPWRKIKDKDQVGEMKEKY---DHRMLLKHCPHE--FHQFMDHIKSLNYEDRPDYQLI
Kinase C27D8.1.AA Dual 24-292 29 2.7e-58 194.58 In-house 1-282 (282) Show / Hide 
Range on Protein: 24-292
Range on HMM: 1-282/282
Sequence Identity: 29% (83 aa)

YTVVRLLGEGGFGAVYLVQDNKS----KKQSAMKVERKIEKRKHSKLKMEIAILKLVGS---------GKHFTQIVDRGKKDKEGFFFLVMELVGKSLAD
  ||.||| |||. || | . .     .|  ..|.|   ...    || |  . ...            |.|   ||.||  .    ..|| ..| || .
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

LKADRPDKVFSFATGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGLDEKRHNIYILDFGIARKYLN--TKNELKTPRETVGFKGTVRFAPIACHRNTE
       . .|  .   |  | |.|.  ||  |..||. || |..|||...   .| .||.|.|||.   .| . .|.| .| . |. |.| .||    .
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENK-KHRTARKKVKMYGCGRYACRACMMQKD

MGPKDDCESWFYLLLDLIVPSG-LPWRKLSDKHEVLKEKEECRKDKRSSLFAGLRQTDYLSKVLDYIDGRAYQDRVDYQFIYKNL
 | ||| |.| |.. ||. |.  ..|||. |  ...|.|..    . .. ..   .   | . ..|..|  |.   ||  .   |
QGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRR--LKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase C27D8.1.AA CK1-Unclassified 24-223 32 4.3e-39 113.03 In-house 1-207 (244) Show / Hide 
Range on Protein: 24-223
Range on HMM: 1-207/244
Sequence Identity: 32% (68 aa)

YTVVRLLGEGGFGAVYLVQDNKSKKQSAMKVERKIEKRKHSKLKMEIAILKLVGSGK-------HFTQIVDRGKKDKEGFFFLVMELVGKSLADLKADRP
| |.. .| | || .|.. . ....  |.|.|.|  |  |. |. |. |.. .  |.       ... .   |. ..... ..||.| |.|| ||.    
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK--HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLF-NMC

DKVFSFATGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACG-LDEKRHNIYILDFGIARKYLNT-KNELKTP-RETVGFKGTVRFAPIACHRNTEMGPKD
 . ||  | |    | .. .| ||. .|||||.|| |.  | |  ..|..|| |||.. .|.   |.    | ||  .. || |.| |  |.  | . .|
NRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRD

DCESWFYLLL
| ||  |.|.
DLESLGYVLI
Kinase C27D8.1.AA CK1-Unique 24-234 26 7.4e-36 121.8 In-house 1-233 (337) Show / Hide 
Range on Protein: 24-234
Range on HMM: 1-233/337
Sequence Identity: 26% (62 aa)

YTVVRLLGEGGFGAVYLVQDNKSK------KQSAMKVERKIEKRKHSKLKMEIAILK---LVG----SGKHFTQIVDRGKKDKEGFFFLVMELVGKSLAD
. |  ..| ||.| |. | . .        .  .|| | .  ..  . |. | ...|   ..      ..|| .. | .  .     ..|| ..|.|.  
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRD--WWWIVMTMHGPSMEE

LKADRPDKVFSFA------TGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGLDE--KRHNIYILDFGIARK--YLNTKNELKTPRETVGFKGTVRFAP
..       |         . .  . |||...|  |. ||.||..|| ||  .     . | .|.||.|| |.   .   .... ||... | |. ...|
CCMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCP

IACHRNTEMGPKDDCESWFYLLLDLIVPS-GLPWR
..||. .| | .|| |||||.|..|.    || |.
CSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase C27D8.1.AA CK1 24-223 32 2.4e-33 112.26 In-house 1-207 (271) Show / Hide 
Range on Protein: 24-223
Range on HMM: 1-207/271
Sequence Identity: 32% (68 aa)

YTVVRLLGEGGFGAVYLVQDNKSKKQS---AMKVERKIEKRKHSKLKMEIAILKLVGS------GKHFTQIVDRGKKDKEGFFFLVMELVGKSLADLKAD
| |.| .|.| || .||. .  ....    |.|.|..  |  |. |. |. |.|          .... ..   |. ... . ..||.| |.|| ||. .
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSK--HPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLF-N

RPDKVFSFATGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGL-DEKRHNIYILDFGIARKYLNTKNELKTP-RETVGFKGTVRFAPIACHRNTEMGPK
  .. ||  | | .  | .. .| .|. .|||||.|| |.  |.   . |..|| |||.| .|.  |.    | ||  .. ||.|.| |  |   | . .
FCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRR

DDCESWFYLLL
|| ||  | |.
DDMESLGYVLM
Kinase C27D8.1.AA CK1-D 24-288 30 8.2e-31 105.86 In-house 1-261 (261) Show / Hide 
Range on Protein: 24-288
Range on HMM: 1-261/261
Sequence Identity: 30% (83 aa)

YTVVRLLGEGGFGAVYLVQDNKSKKQSAMKVERKIEKRKHSKLKMEIAILKLVGSGKHFTQIVDRGKKDKEGFFFLVMELVGKSLADLKADRPDKVFSFA
| . | .| | || .|. .. ..    |.|.|    | || .|..|  . |..  |    .|   |.     .  .||.|.| || ||     .. ||. 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLE--CIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGD--YNVMVMDLLGPSLEDL-FNYCHRKFSLK

TGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGLDEKRHNIYILDFGIARKYLNTKNELKTP-RETVGFKGTVRFAPIACHRNTEMGPKDDCESWFYLL
| | .. | .  .| .|   |||||.|| |.  ||  . . .||.|||.|..|  .. .   | ||     || |.| |  |.  |   .|| ||  |.|
TVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL

LDLIVPSGLPWRKLSDKHEVLKEKEECRKDKRSS-----LFAGLRQTDYLSKVLDYIDGRAYQDRVDYQFI
.     | |||  |  |    ..| |   .|. |     | .|. .    .. ..|     ..|. || ..
MYFNRGS-LPWQGL--KAATKRQKYERICEKKMSTKIDTLCKGYPSE--FQQYMNYCRNLKFDDKPDYCYL
Kinase C27D8.1.AA CK1-A 24-288 27 1.7e-30 104.87 In-house 1-261 (261) Show / Hide 
Range on Protein: 24-288
Range on HMM: 1-261/261
Sequence Identity: 27% (73 aa)

YTVVRLLGEGGFGAVYLVQDNKSKKQSAMKVERKIEKRKHSKLKMEIAILKLVGSGKHFTQIVDRGKKDKEGFFFLVMELVGKSLADLKADRPDKVFSFA
| .|| .| | || .||    .. .. |.|.|.  .| .| .|  |  . ...  .  . ..   |.     .  .||.|.| || ||     .. |.. 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMES--NKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKD--YNVMVMDLLGPSLEDL-FNFCKRRFTMK

TGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGLDEKRHNIYILDFGIARKYLNTKNELKTP-RETVGFKGTVRFAPIACHRNTEMGPKDDCESWFYLL
| | .  | .  .| .|. .|||||.|| |.  |..     ....|||.|.||   . .   | ||     ||.|.| |  |   |   .|| ||  | .
TVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVM

LDLIVPSGLPWRKLSDKHEVLKEKEECRKDKRSSLFAGLRQTDY---LSKVLDYIDGRAYQDRVDYQFI
.     . |||  .  |    | | |   .|. |         .   ..  . |. .  ...  || ..
MYFNRGK-LPWQGM--KAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase C27D8.1.AA Pkinase 24-200 25 6.6e-19 67.93 Pfam 1-179 (293) Show / Hide 
Range on Protein: 24-200
Range on HMM: 1-179/293
Sequence Identity: 25% (49 aa)

YTVVRLLGEGGFGAVYLVQDNKSKKQSAMKVERKIEKRKHSKLKM-----EIAILKLVGSGKHFTQIVDRGKKDKEGFFFLVMELVGKS--LADLK----
|...| .|.|.|| ||. .. .. |. |.|. .|  ..|..|..      ||.|.| . . ..  .. |      ..   .|||....   ..||.    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS

ADRPDKVF--SFATGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGLDEKRHNI----YILDFGIARKYLNTKNELKTPRETVGFKGTVRFAP
. . ...|  |  .   .  | |...| .|. |.|||||||.|  . .| .. .|     | |||.|...      .   . . .| || ....
T-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN--ILID-NNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA
Kinase C27D8.1.AA S_TKc 24-267 21 4.6e-14 29.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-267
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

YTVVRLLGEGGFGAVYLVQDNKSKKQSAMKVERKIEKRKHSKLKMEIAILKLVGSGKHFTQIVDRGKKDKEGFFFLVMELVGK---SLAD-LKADRP---
|...|..|.|.|| ||.....|.... |.|. .        ... ||.|||     ..  .. |       .....|||...    .| | .|  ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

DKVFSFATGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGLDEKRHNIYILDFGIARKYLNTKNELKTPRETVGFKGTVRFAPIACHRNTEMGP-KDD-
...|.  .   . .| ..|.| .|. |.|||||||.|  .       .| | |||.||..               | ||  . .         |. | | 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDW

----CESWFYLLLDLIVPSGLPWRKLSDKHEVLKEKEECR--------KD--KRSSLFAGLR------QTDYL
    |  .  |      |       .    ....  .|..        ||  || .    |.      .  ..
WSCGCILYEMLCGYPPFP------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C27D8.1.AA TyrKc 24-292 17 7e-06 -127.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-292
Range on HMM: 1-280/280
Sequence Identity: 17% (55 aa)

YTVVRLLGEGGFGAVYLVQDNKSKKQSAMKVERKIEKRKHSKLKMEIAILKLVG-SGKHFTQIVDRGKKDKE-----GFFFLVMELVGK-SLAD-LKADR
 |  . |||| || ||. . .    | | |. ..     .  .  |. |.. .| . ..  ...    ....     .  ..|||.. . .| | |.. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

PDKVFSFATGLGVSCQCLEAVEELHKTGFIHRDLKPQNYACGLDEKRHNIYILDFGIARKYLNT-----KNELKTPRETVGFK--GTVRFAPIACHRNT-
|.  .. .. |  . |  .  | ||. ..|||||   |  | ..|..  . | ||| .|.  .        . ....|. | |    .|  .. | .   
PK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARN--CLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

------------------EMGPKDDCE------SWFYLLLDLIVPSGLPWRKL----SDKHEVLKEKEECRKDKRSSLFAGLRQTDYLSKVLDYIDGRAY
                    | .   .      |.. .. ..     .|  .     |                    |   . .| . ..      .  
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------F--VCCPDEMYQIMKQCWHEDP

QDRVDYQFIYKNL
 ||   . |.. .
EDRPTFSEIHECF