Gene F53C3.1 (Nematode worm)

F53C3.1

Species: Nematode worm
Alias: aSWK139, F53C3.1, CE19439
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 3912038-3913362, WormBase Genetic Map location: II:-5.09,

Classification

Group: CK1
Family: Worm6

Sequence

Name Sequence Type Origin Length Description Download
F53C3.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
F53C3.1.AA Protein Genbank 330 None Fasta, JSON

Protein domain

Protein domains of F53C3.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F53C3.1.AA Worm6 24-290 49 6.4e-156 524.29 In-house 1-279 (279) Show / Hide 
Range on Protein: 24-290
Range on HMM: 1-279/279
Sequence Identity: 49% (139 aa)

YTVVRLLGEGGFGAVYLVEQAKTKK--QFAMKVEKKMDTRKHSKLKMEIAILKLVGTCK--HFTKIEDRGKKDKEGYFFIVMQLVGKSLSGLKKERPNQI
..|....|||||||||.||....||  |||||.||.| ..|...||||...||.|. .|  ||.|||||||.|..|...|||.||||.|. |.|.||.. 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FTFGTGMGVGSQCLEAVEELHKQGFIHRDLKPQNYASGQ-----DDERHLIYILDFGIAR--KYLNDKKEMKTPR-ESVAFKASGTIRFAPLSCHRYTEM
|..|||.....|||||.|.||. ||||||.||.|.. |.     |.|.| ||.||||..|  ||.|...|..||| . ..|.   | |.|||.||. .|.
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRG--TVRYAPLACHKGQEQ

GPKDDCESWFYLLIDLILEGGLPWRHCKVKNEVLKIKENTRKDNR---AALYKGIPQTSELNKILDYIDSRAYQDRIDYKFI
..|||||||||.....|.  .|||||.| ...| |.|. .|...|   .... |. ...|.|.|.||||...|.||.|||||
CRKDDCESWFYMMVEMIVG-CLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase F53C3.1.AA CK1 24-290 28 6e-98 331.72 In-house 1-339 (339) Show / Hide 
Range on Protein: 24-290
Range on HMM: 1-339/339
Sequence Identity: 28% (98 aa)

YTVVRLLGEGGFG-AVYLV-----EQAKTK-----KQFAMKVEKK-MDTRKHSKLKMEIAILKLVGT---------CKHFTK---------IEDRGKKDK
..||...|||||| ..|.|     .  |..     ...|||||.|    .......... ..|| |          .|||.|         . . .....
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

EGYFFIVMQLVGKSLSGLKK-ERP-NQIFTFGTGMGVGSQCLEAVEELHKQGFIHRDLKPQNYASGQ-------------DDERHLIYILDFGIAR-KYL
..| ..||.|.|..|. |.| .|. |. |. .|.. .. |.|||.|..|  ||||||.||.|.. |              ..|.. .|..|||.|| ||.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

ND------------KKEMKTPRE---SVAFKASGTIRFAPLSCHRYTEMGPKDDCESWFYLLIDLILEG-GLPWRHCKVKNE-------VLKIKENTRKD
..            ......|||    . |    |.|.....||.  |.|..||..||||.||...  . ||||...| ...       . | .  ..| 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGC-TARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

NRAALYKGIPQTS------ELNKILDYIDSRAYQDRIDYKFI
.   .. .   ..      |. ||..||.|  |.|| ||..|
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase F53C3.1.AA TTBKL 24-294 35 7.4e-71 238.45 In-house 1-288 (288) Show / Hide 
Range on Protein: 24-294
Range on HMM: 1-288/288
Sequence Identity: 35% (105 aa)

YTVVRLLGEGGFGAVYLVEQAKTKKQ-FAMKVEKKMDTRKHSKLKMEIAILKLVG--TCKHFTKIEDRGKKDKEGYFFIVMQLVGKSLSGLKKERPNQI-
...|...||||||.||.|.  |.||. .|||.||.   .. |..|||. .|..     ..|| |. . ||...  | |.||.|.|..|. |.|  ||.  
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKD--YNFMVMTLCGPNLQDLRKMMPNKKR

FTFGTGMGVGSQCLEAVEELHKQGFIHRDLKPQNYASGQDDE----RHLIYILDFGIARKYLND-----------KKEMKTPRE---SVAFKASGTIRFA
|. || . .| |||.|. ..|  ||||||.||.|.. |  |.    ....|..|||.||.|...           |..|..||.   .. |   ||.|..
FSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFR--GTTRYC

PLSCHRYTEMGPKDDCESWFYLLIDLILEGGLPWRHCKVKNEVLKIKENTRKDNRAALYKGIP----QTSELNKILDYIDSRAYQDRIDYKFIYKAL
 .  |.  | |..||  ||.| .| | ..  |||.... | |. . |.|.   .  .| |. |     .||. |.  .. |  |.|| ||  ||. .
SPNMHDRKEQGRHDDLWSWMYMIIELHCG--LPWTNMEDKMEIEHMKKNM---KDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase F53C3.1.AA TTBK 24-290 39 2.7e-63 216.6 In-house 1-257 (257) Show / Hide 
Range on Protein: 24-290
Range on HMM: 1-257/257
Sequence Identity: 39% (105 aa)

YTVVRLLGEGGFGAVYLVEQAKTK-KQFAMKVEKKMDTRKHSKLKMEIAILKLVGTCKHFTKIEDRGKKDKEGYFFIVMQLVGKSLSGLKKERPNQIFTF
 .||.  | |||| .|  .   ..  | |.||| . .. |   ||||.|.||    |.|  .    |  ||  . ..|||| ||.|. |  . | . |. 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVE-SAQQPKQV-LKMEVAVLKKLQGCDHVCRFIGCGRNDK--FNYMVMQLQGKNLADLRRKQPRGCFSL

GTGMGVGSQCLEAVEELHKQGFIHRDLKPQNYASGQD-DERHLIYILDFGIARKYLNDKKEMKTPRESVAFKASGTIRFAPLSCHRYTEMGPKDDCESWF
.| . .| | |...|. |  || ||| || |.| |.   ..  .|.|||| ||.|.| . |  .|||.  |   ||.|.|    ||  ||| .||  | |
STTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFR--GTVRYASINAHRNREMGRHDDLWSLF

YLLIDLILEGGLPWRHCKVKNEVLKIKENTRKDNRAALYKGIPQTSELNKILDYIDSRAYQDRIDYKFI
|.|.  . .| ||||  | |..| ..||   | .   | | .|  .|.   .| | |  |.|| ||..|
YMLVEFV-QGQLPWRKIKDKDQVGEMKE---KYDHRMLLKHCP--HEFHQFMDHIKSLNYEDRPDYQLI
Kinase F53C3.1.AA Dual 24-294 27 3e-47 156.89 In-house 1-282 (282) Show / Hide 
Range on Protein: 24-294
Range on HMM: 1-282/282
Sequence Identity: 27% (80 aa)

YTVVRLLGEGGFGAVYLVEQAKT----KKQFAMKVEKKMDTRKHSKLKMEIAILKLVGT---------CKHFTKIEDRGKKDKEGYFFIVMQLVGKSLSG
  ||.||| |||. || | . .     .| ...|.|     .    || |  . ...            |.|    |.||  .    ..|| ..| ||  
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

LKKERPNQIFTFGTGMGVGSQCLEAVEELHKQGFIHRDLKPQNYASGQDDERHLIYILDFGIARKYLN-DKKEMKTPRESVAFKASGTIRFAPLSCHRYT
  .   .  ..  .   |. | |.|.  ||  |..||. || |.. | ...   .| .||.|.|||.    |. .|.|  |  |  |. |.|   |    
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKV--KMYGCGRYACRACMMQK

EMGPKDDCESWFYLLIDLILEGG-LPWRHCKVKNEVLKIKENTRKDNRAALYKGIPQTSELNKILDYIDSRAYQDRIDYKFIYKAL
. | ||| |.| |.. ||. ..  ..||     |...| |.|    .    |  ||.  .| ....|...  |.   ||  .   |
DQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPR--RLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase F53C3.1.AA CK1-Unique 24-240 28 2.5e-41 141.02 In-house 1-237 (337) Show / Hide 
Range on Protein: 24-240
Range on HMM: 1-237/337
Sequence Identity: 28% (69 aa)

YTVVRLLGEGGFGAVYLVEQAKTK------KQFAMKVEKKMDTRKHSKLKMEIAILKLVGTCK-------HFTKIEDRGKKDKEGYFFIVMQLVGKSLSG
. |  ..| ||.| |. | . ..       . ..|| | .   .  . |. | ...|   .|        || ...| .  .   . .|||...|.|.  
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRD--WWWIVMTMHGPSMEE

LKKERPNQIFTFG------TGMGVGSQCLEAVEELHKQGFIHRDLKPQNYASGQDD--ERHLIYILDFGIARK--YLNDKKEMKTPRESVAFKASGTIRF
..    |  || .      .    | |||...|  |. ||.||..|| ||  .     . | .|.||.|| |.   .    ... ||. . |   |. ..
CCMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFR--GCKDY

APLSCHRYTEMGPKDDCESWFYLLIDLIL-EGGLPWRHCKV
.| |||. .| | .|| |||||.|..|.. . || |.  |.
CPCSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWKLDKI
Kinase F53C3.1.AA CK1-Unclassified 24-180 31 9.6e-32 90.98 In-house 1-163 (244) Show / Hide 
Range on Protein: 24-180
Range on HMM: 1-163/244
Sequence Identity: 31% (52 aa)

YTVVRLLGEGGFGAVYLVEQAKTKKQFAMKVEKKMDTRKHSKLKMEIAILKLVGTCK-------HFTKIEDRGKKDKEGYFFIVMQLVGKSLSGLKKERP
| |.. .| | || .|..   .|.. .|.|.||| .   |. |. |. |.. .  ..       ...|.   |. ....| ..|| | |.||  |..   
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK--HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFN-MC

NQIFTFGTGMGVGSQCLEAVEELHKQGFIHRDLKPQNYASG-QDDERHLIYILDFGIARKYLN-DK
|. |.  | .  . | .. .| ||. .|||||.|| |.  |    ..| .|| |||.. .|.  ||
NRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDK
Kinase F53C3.1.AA CK1-A 24-290 27 3.3e-28 96.7 In-house 1-261 (261) Show / Hide 
Range on Protein: 24-290
Range on HMM: 1-261/261
Sequence Identity: 27% (75 aa)

YTVVRLLGEGGFGAVYLVEQAKTKKQFAMKVEKKMDTRKHSKLKMEIAILKLVGTCKHFTKIEDRGKKDKEGYFFIVMQLVGKSLSGLKKERPNQIFTFG
| .|| .| | || .||  . .  .. |.|.|..    .| .|  |  . ...  |  . ...  |.     |  .||.|.| ||  |     .  ||. 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNK--ARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKD--YNVMVMDLLGPSLEDL-FNFCKRRFTMK

TGMGVGSQCLEAVEELHKQGFIHRDLKPQNYASGQDDERHLIYILDFGIARKYLNDKKEMKTPRESVAFKASGTIRFAPLSCHRYTEMGPKDDCESWFYL
| . .  | .  .| .|...|||||.|| |.  | .     ....|||.|.||   . .   |      .  ||.|.| .  |   |   .|| ||  | 
TVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDK-NLTGTARYASINAHLGIEQSRRDDMESMGYV

LIDLILEGGLPWRHCKV---KNEVLKIKENTRKDNRAALYKGIPQTSELNKILDYIDSRAYQDRIDYKFI
..   . | |||   |    |    || |       . | || |  .|.  .. |. .  ...  || ..
MMYFNR-GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFP--AEFCMYMNYCRNLRFEEQPDYMYL
Kinase F53C3.1.AA CK1 24-180 32 8e-27 89.49 In-house 1-163 (271) Show / Hide 
Range on Protein: 24-180
Range on HMM: 1-163/271
Sequence Identity: 32% (54 aa)

YTVVRLLGEGGFGAVYLVEQAKTKKQF---AMKVEKKMDTRKHSKLKMEIAILKLVGT------CKHFTKIEDRGKKDKEGYFFIVMQLVGKSLSGLKKE
| |.| .|.| || .||..   |....   |.|.| |.... |. |. |. |.|          |... ..   |. ... | ..|| | |.||  |.. 
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLE-KNKSK-HPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFN-

RPNQIFTFGTGMGVGSQCLEAVEELHKQGFIHRDLKPQNYASGQ-DDERHLIYILDFGIARKYLNDK
  |. |.  | . .. | .. .| .|. .|||||.|| |.  |    . | .|| |||.| .|. ||
FCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDK
Kinase F53C3.1.AA CK1-D 24-290 29 1.8e-26 90.31 In-house 1-261 (261) Show / Hide 
Range on Protein: 24-290
Range on HMM: 1-261/261
Sequence Identity: 29% (79 aa)

YTVVRLLGEGGFGAVYLVEQAKTKKQFAMKVEKKMDTRKHSKLKMEIAILKLVGTCKHFTKIEDRGKKDKEGYFFIVMQLVGKSLSGLKKERPNQIFTFG
| . | .| | || .|. .. .|    |.|.|      || .|..|  . |..       .|   |.     |  .||.|.| ||  |     .  | . 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIK--TKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGD--YNVMVMDLLGPSLEDL-FNYCHRKFSLK

TGMGVGSQCLEAVEELHKQGFIHRDLKPQNYASGQDDERHLIYILDFGIARKYLNDKKEMKTP-RESVAFKASGTIRFAPLSCHRYTEMGPKDDCESWFY
| . .. | .  .| .| . |||||.|| |.  |     ...||.|||.|..|   . .   | ||       || |.| .  |.  |   .|| ||  |
TVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNL--TGTARYASINTHQGIEQSRRDDLESLGY

LLIDLILEGGLPWRHCKV---KNEVLKIKENTRKDNRAALYKGIPQTSELNKILDYIDSRAYQDRIDYKFI
.|.     | |||   |    ..   .| |   . .   | || |  ||  . ..|  .  ..|. || ..
VLM-YFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYP--SEFQQYMNYCRNLKFDDKPDYCYL
Kinase F53C3.1.AA Pkinase 24-186 25 1.4e-19 70.36 Pfam 1-171 (293) Show / Hide 
Range on Protein: 24-186
Range on HMM: 1-171/293
Sequence Identity: 25% (47 aa)

YTVVRLLGEGGFGAVYLVEQAKTKKQFAMKVEKKMDTRKHSKLKM-----EIAILKLVGTCKHFTKIEDRGKKDKEGYFFIVMQLVGK-----SLS----
|...| .|.|.|| ||.    .| |..|.|. ||  ..|..|..      ||.|.| .  ...  .. |      ...  .|| ....     .|.    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS

GLKKERPNQIF--TFGTGMGVGSQCLEAVEELHKQGFIHRDLKPQN--YA-SGQDDERHLIYILDFGIARKY-LNDKKEMKTP
.    . .  |  .  .   .  | |...| .|..|.|||||||.|  .   |. |.   . | |||.|... .  .  |.|.
T----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS-MTTF
Kinase F53C3.1.AA S_TKc 24-294 17 4.5e-14 29.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-294
Range on HMM: 1-231/231
Sequence Identity: 17% (53 aa)

YTVVRLLGEGGFGAVYLVEQAKTKKQFAMKVEKKMDTRKHSKLKMEIAILKLVGTCKHFTKIEDRGKKDKEGYFFIVMQLVGK---SLSGLKKERPN---
|...|..|.|.|| ||..   ||....|.|. |        ... ||.|||    ...  |. |       .....|| ...    .|  . |.|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-QIFTFGTGMGVGSQCLEAVEELHKQGFIHRDLKPQN--YASGQDDERHLIYILDFGIARKYLNDKKEMKTPRESVAFKASGTIRFAPLSCHRYTEMGPK
 . |.  .   .  | ..|.| .|..|.|||||||.|    .        | | |||.||..                   ||  . .            
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL---------------TTFCGTPWYMAPEVL--------

DDCESWFY----------LLIDLILEGGLPWRHCKVKNEVLKIKENTRKDNRAALYKGIPQTSELNKILDYIDSRAYQDRIDYKFIYK---------AL
    .. .          .|. ..  |  |..      .. .. .. .             ..|.  ... .  .  ..|.    . .          .
----GYGKCKCDWWSCGCILYEMLC-GYPPFP------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase F53C3.1.AA TyrKc 24-294 20 4e-06 -123.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-294
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YTVVRLLGEGGFGAVYLVEQAKTKKQFAMKVEKKMDTRKHSKLKMEIAILKLVG-TCKHFTKIEDRGKKDKE-----GYFFIVMQLV--GKSLSGLKKER
 |  . |||| || ||. .      | | |. |.     .  .  |. |.. .|   ..  ..     ....     .  .||| ..  |  .. |.| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

PNQIFTFGTGMGVGSQCLEAVEELHKQGFIHRDLKPQN--YASGQDDERHLIYILDFGIARKYLND-----KKEMKTPRESVAFKASGTIRFAPLSCHRY
|.  ..  .      |  .  | ||....|||||   |  .....      . | ||| .|.  .|      |......|.   |.   ||  .. | .|
PK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

TEMGPKDDCESWFYLLIDLILEGGLPWRH-----CKVKNEVLKIKENTRKDNRAALYKGIP-----QTSELNKILDYIDSRAYQDRIDYKFIYKAL
 .  .| |  |.  ..  .   |. |.       .. .  . ..|.  | .  .  |   |      ..|. .|      .   ||   . |.. .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF