Gene pmk-2 (Nematode worm)

pmk-2

Species: Nematode worm
Alias: F42G8.3a, F42G8.3, pmk-2, aSWK201, CE31695
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 8143498-8148318, WormBase Genetic Map location: n/a,

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
pmk-2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 331 Kinase domain by global Sugen HMM Fasta, JSON
pmk-2.AA Protein Genbank 448 None Fasta, JSON

Protein domain

Protein domains of pmk-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase pmk-2.AA p38 49-379 57 2.7e-209 701.58 In-house 1-289 (289) Show / Hide 
Range on Protein: 49-379
Range on HMM: 1-289/289
Sequence Identity: 57% (193 aa)

YNSLKPLGEGAYGVVCTAEYEPTGDR---VAIKKFFRPFQSTIHAKRTYRELKLLRTLQHDNVLEMIDVFTP-DPDASSLNNVYFVSVLMGSDLQNIMKI
|..|.|.|.|||| ||.||.. ||..   |||||..|||||.||||||||||.||....|.||....||||| . .......||.|. .||.||.||||.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QRLTDEQIQLLIYQVLRGLKYMSHQNFNSTIILKKLMHPFQRRNTRFRLYIHSAGIIHRDLKPSNIAVNERCEVKVFLSFSQLSFLILSFFKILDFGLAR
|||.|..||.|.||.|||||                             |||||||||||||||||||||.||.                 .||||||||
QRLSDDHIQFLVYQILRGLK-----------------------------YIHSAGIIHRDLKPSNIAVNEDCEL-----------------RILDFGLAR

AQDAEMTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEARNYIKNRSPIIRQDFVTL
..|.||||||||||||||||||||||||||||.||||||.|||..||.|||||||||||..||.|.|||.||||.|||||||||||...... |.|| ..
HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHV

FPMASPYALELLEMMLILDPDRRISVSSALRHDYL
|..|.|.|..|||.||.||||.||....|..|.|.
FMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase pmk-2.AA MAPK 49-379 45 5.6e-178 597.55 In-house 1-328 (328) Show / Hide 
Range on Protein: 49-379
Range on HMM: 1-328/328
Sequence Identity: 45% (168 aa)

YNSLKPLGEGAYGVVCTAEYEP------TGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTL-QHDNVLEMIDVFTPD-----PDASSLNNVYFVSVLMGS
|. |||.|.||||||| |   .      .|..|||||..||||...|.||||||.|||| . .|.|.  ..|.|||.     .. ...| .|.|. ||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLQNIMKIQR-LTDEQIQLLIYQVLRGLKYMSHQNFNSTIILKKLMHPFQRRNTRFRLYIHSAGIIHRDLKPSNIAVNERCEVKVFLSFSQLSFLILSFF
||..|.| |. |.|. || ..||.|||||                             |||||..||||||||||.||| |..                 
DLHQIIKSQQPLSDDHIQYFMYQILRGLK---------------------------LKYIHSANVIHRDLKPSNILVNENCDL-----------------

KILDFGLARAQDAE-----------------MTGYVATRWYRAPEIMLN--WMHYTQTVDVWSVGCILAELVS-GRPLFPGDDHIDQLTKIMSVVGTPKE
||.||||||  | |                 ||.|||||||||||||||  |||||..||.||||||.||... ..|||||.|.|||...||.|.|||.|
KICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSE

EFWSKIQ-SEEARNYIKNR---SPIIRQDFVTLFPM----ASPYALELLEMMLILDPDRRISVSSALRHDYL
||...|. ||.|||||...    .  .... ..||     |.| |. ||| || .|||.||.|  ||.| |.
EFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase pmk-2.AA CMGC 49-379 25 6.6e-129 426.09 In-house 1-513 (513) Show / Hide 
Range on Protein: 49-379
Range on HMM: 1-513/513
Sequence Identity: 25% (141 aa)

YNSLKPLGEGAYGVVCTAEY--------------EPTGDRVAIKKFFRPFQSTIHAK----------RTYRELKLLRTLQ-----------------HDN
|  .|..|||.||||. .                  |. .|||||...||  ...||          |..||.|.|. |.                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VLEMIDVFTPDPDASS-----------LNNVYFVSVLMGSDLQNIMKIQR----------LTDEQ------------IQLLI------YQVLRGLKYMSH
.. ..|.|... ....           .|..|.|  .|. || ...| ..          |.. .            |. ..      ||.|||||    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLK----

QNFNSTIILKKLMHPFQRRNTRFRLYIHSAG--IIHRDLKPSNIAVNERCEVKVFLSFSQLSFLILSFF--------------KILDFGLARAQDAE---
                         |.||..  ||||||||.|| .|..||... .            .              || ||||||. . .   
-----------------------LKYCHSHWGNIIHRDLKPENILINHNCELITRM-M----------WKSEDWNPCQKNGRLKICDFGLARWYHPHSDH

---------------------MTGYVATRWYRAPEIMLNW---------MHYTQTVDVWSVGCILAELVSG--------RPLFP-----------GDDHI
                     .| ||.|||||||||.|.|         ||||...|.||||||.||.. |        .||||           |..||
HFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHI

DQLTKIMSVVGTP----------------KEEFWSKIQ--------------------SEEARNYIKN---RSPIIRQDFVTLFPM--------------
||| ||. | |||                .||. ..|.                    || |||||..     .. ....  |||               
DQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVF

---------------------ASPYALELLEMMLILDPDRRISVSSALRHDYL
                     ..| |..||. ||..|||.||... ||.|.|.
NWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase pmk-2.AA ERK 236-379 48 5e-69 235.64 In-house 148-307 (307) Show / Hide 
Range on Protein: 236-379
Range on HMM: 148-307/307
Sequence Identity: 48% (77 aa)

KILDFGLARAQDA-----------EMTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTP-KEEFWSKIQS
|| |||||| .||            ||.||||||||||||||.|  ||. .|.||.|||.||.. ..||||| |...|.. | .. |||  ||  ..|.|
KICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICS

EEARNYIKNRSP--IIRQDFVTLFPMAS--PYALELLEMMLILDPDRRISVSSALRHDYL
|.|..|||| .   .  ... ..|| |.  | |..||| ||  ||| ||.|  .|.| |.
ENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase pmk-2.AA S_TKc 49-379 24 4.4e-65 223.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-379
Range on HMM: 1-231/231
Sequence Identity: 24% (84 aa)

YNSLKPLGEGAYGVVCTAEYEPTGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQHDNVLEMIDVFTPDPDASSLNNVYFVSVLMGS---DLQNIMKIQ
|  |...|.||.|.|. .    || .||||.           ....||...|.  .|.|.  ..|||         ...|.|  ...    ||  ..| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

R-------LTDEQIQLLIYQVLRGLKYMSHQNFNSTIILKKLMHPFQRRNTRFRLYIHSAGIIHRDLKPSNIAVNERCEVKVFLSFSQLSFLILSFFKIL
.       ..  ... ..||....|.|.                             || |||||||||.|| ..|                     || 
GRHGLRFPFPE-HARFYMYQICCALEYC-----------------------------HSHGIIHRDLKPENILLDE-------------------HIKIC

DFGLARAQDAEMTGYVATRWYRAPEIMLNWMHYTQ-TVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEARNYIKNRSPII
||||||      | .. |.||.|||..    .|.   .|.||.||||.|...|.|.||      |. ... ..|                          
DFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------

RQDFVTLFPMASPYALELLEMMLILDPDRRISVSSALR-------HDYL
           || |..... .|  ||..|...  ||.       | ..
-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase pmk-2.AA ERK1 236-379 50 2.8e-53 183.31 In-house 140-289 (289) Show / Hide 
Range on Protein: 236-379
Range on HMM: 140-289/289
Sequence Identity: 50% (76 aa)

KILDFGLARAQDAE------MTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEARNY
|| ||||||  | |      .| |||||||||||||||   ||. .|.|||||||||..| ||.|||   .||| .|..|.| | ..    |  | ||||
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNY

IKNRSPIIRQDFVTLFPMASPYALELLEMMLILDPDRRISVSSALRHDYL
..      .. .  ||| | . ||.||. ||   |..|| |  || | ||
LQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase pmk-2.AA Pkinase 194-379 31 2.7e-49 174.86 Pfam 123-293 (293) Show / Hide 
Range on Protein: 194-379
Range on HMM: 123-293/293
Sequence Identity: 31% (60 aa)

YIHSAGIIHRDLKPSNIAVNERCEVKVFLSFSQLSFLILSFFKILDFGLAR---AQDAEMTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVSG
|.|| |||||||||.|| ........              ..|| |||||.       .||... |.||.|||. .   .|.. ||.||.||||.|...|
YCHSMGIIHRDLKPENILIDNNGHIDA-------------CVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCG

RPLFPGD----DHIDQLTKIMSVVGTPKEEFWSKIQSEEARNYIKNRSPIIRQDFVTLFPMASPYALELLEMMLILDPDRRISVSSALRHDYL
||.|||.    . .||. .|  . |.| .. |..  |.  .. ..       . . |. . .|. ...... .| .|| .|..   .| |...
RPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase pmk-2.AA ERK7 236-379 38 4.5e-49 165.82 In-house 140-292 (292) Show / Hide 
Range on Protein: 236-379
Range on HMM: 140-292/292
Sequence Identity: 38% (59 aa)

KILDFGLARA---------QDAEMTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEA
|. ||||||          |.  .| ||||||||||||.|   .||. || ||.||||.|.. |.|.|||   ..|. ||. ... |..|    |.|. |
KVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYA

RNYIKNRSPIIRQDFVTLFPMASPYALELLEMMLILDPDRRISVSSALRHDYL
 | ...     |. .  ..|.... |..||  .|.. |..|...  ||.| | 
WNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase pmk-2.AA ERK5 236-379 41 9.2e-48 164.99 In-house 143-295 (295) Show / Hide 
Range on Protein: 236-379
Range on HMM: 143-295/295
Sequence Identity: 41% (64 aa)

KILDFGLARAQDA--------EMTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEAR
|| |||.||             || |||||||||||.|.    ||| .||||||||. |... | .|||   |.||  || |.|.|       . ..  .
KIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVY

NYIKN-RSPIIRQDFVTLFPMASPYALELLEMMLILDPDRRISVSSALRHDYL
||..   ..   .|. ...| | . ||.||  ||. .|  ||.|  ||.| .|
NYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase pmk-2.AA ERK 49-166 41 2.8e-45 156.74 In-house 1-124 (307) Show / Hide 
Range on Protein: 49-166
Range on HMM: 1-124/307
Sequence Identity: 41% (52 aa)

YNSLKPLGEGAYGVVCTAEYEP-----TGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQ-HDNVLEMIDVFTPDPDASSLNNVYFVSVLMGSDLQNIM
|. .|..|.|||||||.| . .     ||..||||| ...|  .| .|||.||.|||| .  |.|.   .|.. |..   ..|..|.|. || .||. | 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE-QYNDIYCVEELMETDLHQII

KIQ-RLTDEQIQLLIYQVLRGLKYM
. | .|.|. .| ..|| |.||||.
NSQQELSDDHCQYFMYQILCGLKYI
Kinase pmk-2.AA JNK 236-333 51 5.1e-44 152.55 In-house 146-245 (309) Show / Hide 
Range on Protein: 236-333
Range on HMM: 146-245/309
Sequence Identity: 51% (52 aa)

KILDFGLARAQDAE--MTGYVATRWYRAPEIMLNWM-HYTQTVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEARNYIKN
||.|||.|| .|    || || ||.|||||. .  |  |.  ||.||||||.||.. .. |||| ||||| .||... |||  .| .. | . .|||..|
KICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEMIRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQ-PHVRNYVEN

R
|
R
Kinase pmk-2.AA nmo 236-379 43 5.5e-42 126.51 In-house 142-292 (292) Show / Hide 
Range on Protein: 236-379
Range on HMM: 142-292/292
Sequence Identity: 43% (66 aa)

KILDFGLARAQDAE----MTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEARNYIK
|| |||||| .. .    ||  | | .||||||..   |||. ||.|||||| |||.  | ||     |.||  |. ..|||  |   |   | |.. . 
KICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHML

NRSPIIRQDFVTLFPMAS-----PYALELLEMMLILDPDRRISVSSALRHDYL
 | |    ..  |. ..|       | .||  ||. |||.|||.  || | ||
-RMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase pmk-2.AA MAPK-Unclassified 249-379 33 5.6e-42 145.78 In-house 404-575 (575) Show / Hide 
Range on Protein: 249-379
Range on HMM: 404-575/575
Sequence Identity: 33% (57 aa)

EMTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVSG-----------RPLFPGDD--------------------HIDQLTKIMSVVGTPKEEF
.||.||.|||||||||||    |.  || ||.|||.||...            ||||||.|                    |.||.  | .. |.|.|| 
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

WSKIQSEEARNYIKNRSPIIRQDFVTLFPMASP----------YALELLEMMLILDPDRRISVSSALRHDYL
 . |..  || ||.   .  . .|  |.. . |           .. ..  ||  .| .||.   || | | 
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase pmk-2.AA ERK5 49-166 47 1.1e-33 118.29 In-house 1-119 (295) Show / Hide 
Range on Protein: 49-166
Range on HMM: 1-119/295
Sequence Identity: 47% (56 aa)

YNSLKPLGEGAYGVVCTAEYEPTGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQHDNVLEMIDVFTPDPDASSLNNVYFVSVLMGSDL-QNIMKIQRL
|. .  .|.||||||| |    .|..|||||    |     ||||.||||.||  .|||.. . |.  |    | . .|| |  || ||| | |   | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TDEQIQLLIYQVLRGLKYM
| | |   .||.|||||||
TLEHIRYFLYQILRGLKYM
Kinase pmk-2.AA JNK 49-166 36 3.4e-33 116.62 In-house 1-122 (309) Show / Hide 
Range on Protein: 49-166
Range on HMM: 1-122/309
Sequence Identity: 36% (45 aa)

YNSLKPLGEGAYGVVCTAEYEPTGDRVAIKKFFRP--FQSTIHAKRTYRELKLLRTLQHDNVLEMIDVFTPDPDASSLNNVYFVSVLMGSDLQNIMK--I
|  ||..| || |.|| |    |. ||||||  ||  || . |.|| |||.... ...|.|.  |  .|||.   .... || |  .|   | ..     
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

QRLTDEQIQLLIYQVLRGLKYM
 .|  | .  |.||...| |..
MELDHERMSYLFYQMCCGIKHL
Kinase pmk-2.AA nmo 50-166 40 4.5e-31 92.32 In-house 2-118 (292) Show / Hide 
Range on Protein: 50-166
Range on HMM: 2-118/292
Sequence Identity: 40% (48 aa)

NSLKPLGEGAYGVVCTAEYEPTGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQHDNVLEMIDVFTPDPDASSLNNVYFVSVLMGSDLQNIM-KIQRLT
.  .|.| ||.||| .      | |||.||.   ||. . .|| .||||.|   .|||||   |.  | |. . ....| |  || |||  |.   | |.
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQP-PHKDFFQEIYVVTELMQSDLHKIIVSPQHLS

DEQIQLLIYQVLRGLKYM
 . ..  .||.||||||.
SDHVKVFLYQILRGLKYL
Kinase pmk-2.AA MAPK-Unclassified 49-166 35 3.1e-28 98.93 In-house 1-125 (575) Show / Hide 
Range on Protein: 49-166
Range on HMM: 1-125/575
Sequence Identity: 35% (44 aa)

YNSLKPLGEGAYGVVCTAEYEPT-GDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQHDNVLEMIDVFTPDPDAS-SLNNVYFVSVLMGS---DLQNIMK
|   | .| ||||.|| |    . .  |||||  . |.  . .||. ||. .|| | | |..   |.|... .       .| |  .| .   ||  | |
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

IQR--LTDEQIQLLIYQVLRGLKYM
     . ...|| ..|| ||||||.
SNQDHWCHQHIQYFFYQILRGLKYL
Kinase pmk-2.AA ERK1 49-170 40 1.4e-26 94.66 In-house 1-120 (289) Show / Hide 
Range on Protein: 49-170
Range on HMM: 1-120/289
Sequence Identity: 40% (49 aa)

YNSLKPLGEGAYGVVCTAEYEPTGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQHDNVLEMIDVFTPDPDASSLNNVYFVSVLMGSDLQNIMKIQRLT
|  |. .||||||.|| |  . ...||||||   ||    . .|| ||.|.|   .|.|.... |.   |    ..  || |  ||  ||  ..| |.| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKK-ISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRAD-TIEQMRDVYIVQCLMETDLYKLLKTQHLS

DEQIQLLIYQVLRGLKYMSHQN
 . |   .||.||||||.   |
NDHICYFLYQILRGLKYIHSAN
Kinase pmk-2.AA ERK7 49-166 35 6.4e-26 85.39 In-house 1-116 (292) Show / Hide 
Range on Protein: 49-166
Range on HMM: 1-116/292
Sequence Identity: 35% (43 aa)

YNSLKPLGEGAYGVVCTAEYEPTGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQ-HDNVLEMIDVFTPDPDASSLNNVYFVSVLMGSDLQNIMK-IQR
|. .| || ||||.|  |    |.. ||.|| |  |.  . | ||.||  .|. .. |.|.. .|.|.     |.    .| |   | .|| .. .  . 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR----ADNDRDIYLVFEFMETDLHAVIRKGNI

LTDEQIQLLIYQVLRGLKYM
| |   |  .||.|| .|||
LKDIHKQYIMYQLLRAIKYM
Kinase pmk-2.AA Pkinase 49-166 22 3.3e-23 83.14 Pfam 1-124 (293) Show / Hide 
Range on Protein: 49-166
Range on HMM: 1-124/293
Sequence Identity: 22% (29 aa)

YNSLKPLGEGAYGVVCTAEYEPTGDRVAIKKFFRPFQSTIHAKRTYR--ELKLLRTLQHDNVLEMIDVFTPDPDASSLNNVYFVSVLM-GS----DLQNI
|  ....|.|..|.|. .    ||..||.|.. .. ..    ..  |  |..... |.|.|.....|.|.        ...|.|  .. |     ||  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

MK---IQRL--TDEQIQLLIYQVLRGLKYM
..     ..  ......  .||.||||.|.
ISTWRHGCFYFSEWECKFYMYQILRGLEYC
Kinase pmk-2.AA JNK 194-220 66 2.3e-13 46.03 In-house 121-147 (309) Show / Hide 
Range on Protein: 194-220
Range on HMM: 121-147/309
Sequence Identity: 66% (18 aa)

YIHSAGIIHRDLKPSNIAVNERCEVKV
. ||.|||||||||||| ||..| .|.
HLHSMGIIHRDLKPSNIVVNQDCTLKI
Kinase pmk-2.AA MAPK-Unclassified 194-220 62 9.6e-13 41.91 In-house 124-150 (575) Show / Hide 
Range on Protein: 194-220
Range on HMM: 124-150/575
Sequence Identity: 62% (17 aa)

YIHSAGIIHRDLKPSNIAVNERCEVKV
|.|||.||||||||||. .|. | |..
YLHSACIIHRDLKPSNLLINQDCSVRI
Kinase pmk-2.AA TyrKc 49-379 18 3.4e-12 -25.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 49-379
Range on HMM: 1-280/280
Sequence Identity: 18% (68 aa)

YNSLKPLGEGAYGVVCTAEYEPTGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTL--QHDNVLEMIDVFTPDPDASSL---NNVYFVSVLMGS-DLQNIM
   .| |||||.|.|. ...      ||.|.           .  .||..... |  .|.|.. .. | | .           .. |  .|   ||..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYL

KIQR--LTDEQIQLLIYQVLRGLKYMSHQNFNSTIILKKLMHPFQRRNTRFRLYIHSAGIIHRDLKPSNIAVNERCEVKVFLSFSQLSFLILSFFKILDF
.  |  |. ..     .|. .|  | ...                             ..|||||   |. |.|.                    || ||
RKHRPKLCMKDLLSFCWQIACGMEYLHSK-----------------------------NCIHRDLAARNCLVGENH-----------------TVKISDF

GLARAQDAE--------MT-------GY--VATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVS-GRPLFPG-------DDHIDQLTKIMSVVGTPKE
||.|. . .        .        |   .  ||. ||| . |   .|   |||| |  . |. . | .  ||       .... .. |       |..
GLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPN

--EFWSKIQSEEARNYIKNRSPIIRQDFVTLFPMASPYALELLEMMLILDPDRRISVSSALRHDYL
  .  |                         |. ...   .. ..    ||. | . |    |...
DYP-MS-------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase pmk-2.AA ERK5 194-220 70 8.5e-12 39.39 In-house 118-144 (295) Show / Hide 
Range on Protein: 194-220
Range on HMM: 118-144/295
Sequence Identity: 70% (19 aa)

YIHSAGIIHRDLKPSNIAVNERCEVKV
|.||| .|||||||||. ||| ||.|.
YMHSAQVIHRDLKPSNLLVNENCELKI
Kinase pmk-2.AA ERK7 194-220 62 2.9e-11 34.43 In-house 115-141 (292) Show / Hide 
Range on Protein: 194-220
Range on HMM: 115-141/292
Sequence Identity: 62% (17 aa)

YIHSAGIIHRDLKPSNIAVNERCEVKV
|.||. .|||||||||| ..  | |||
YMHSGNVIHRDLKPSNILLDSECMVKV
Kinase pmk-2.AA ERK 193-220 67 6.6e-11 37.02 In-house 122-149 (307) Show / Hide 
Range on Protein: 193-220
Range on HMM: 122-149/307
Sequence Identity: 67% (19 aa)

LYIHSAGIIHRDLKPSNIAVNERCEVKV
.|||||..|||||||||| ||. |  |.
KYIHSANVIHRDLKPSNILVNSNCDLKI
Kinase pmk-2.AA nmo 194-220 55 1e-08 22.27 In-house 117-143 (292) Show / Hide 
Range on Protein: 194-220
Range on HMM: 117-143/292
Sequence Identity: 55% (15 aa)

YIHSAGIIHRDLKPSNIAVNERCEVKV
|.|||.|.|||.|| |. ||  | .|.
YLHSANILHRDIKPGNLLVNSNCVLKI
Kinase pmk-2.AA ERK1 194-220 59 1.4e-08 28.25 In-house 115-141 (289) Show / Hide 
Range on Protein: 194-220
Range on HMM: 115-141/289
Sequence Identity: 59% (16 aa)

YIHSAGIIHRDLKPSNIAVNERCEVKV
||||| ..||||||||. .|  |..|.
YIHSANVLHRDLKPSNLLLNTTCDLKI
Kinase pmk-2.AA JNK 355-379 56 3.7e-08 26.5 In-house 285-309 (309) Show / Hide 
Range on Protein: 355-379
Range on HMM: 285-309/309
Sequence Identity: 56% (14 aa)

LLEMMLILDPDRRISVSSALRHDYL
||  ||. .||.||||  ||.| |.
LLFRMLVINPDDRISVDDALQHPYI
Kinase pmk-2.AA Pkinase_Tyr 49-112 25 3e-06 21.71 Pfam 1-70 (270) Show / Hide 
Range on Protein: 49-112
Range on HMM: 1-70/270
Sequence Identity: 25% (18 aa)

YNSLKPLGEGAYGVVCTAEYE----PTGDRVAIKKFFRPFQSTIHA---KRTYRELKLLRTL-QHDNVLEMI
   .| |||||.|.|. ...      |.  ||.|.  .. ... ..   .   ||.|....| .|.|.. ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase pmk-2.AA Pkinase_Tyr 239-279 33 0.812052 3.39 Pfam 154-199 (270) Show / Hide 
Range on Protein: 239-279
Range on HMM: 154-199/270
Sequence Identity: 33% (16 aa)

DFGLARAQ-------DAEMTGYVATRWYRAPEIMLNWMHYTQTVDVWS
||||||.         .   | .  .|. ||| . .   .|   ||||
DFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGK-FTTKSDVWS