Gene ZK354.2 (Nematode worm)

ZK354.2

Species: Nematode worm
Alias: ZK354.2a, CE15314, ZK354.2, aSWK146
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:1.77, WormBase Physical Map location: IV: 5313477-5315174

Classification

Group: CK1
Family: Worm6

Sequence

Name Sequence Type Origin Length Description Download
ZK354.2.AA Protein Genbank 390 None Fasta, JSON
ZK354.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 271 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of ZK354.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ZK354.2.AA Worm6 21-288 40 9.90000000001e-138 463.86 In-house 1-279 (279) Show / Hide 
Range on Protein: 21-288
Range on HMM: 1-279/279
Sequence Identity: 40% (113 aa)

YEVTKPLATGTFGSIYKAKRESDGK--FFAVKCEA--LNMKSS-LLRQMSVVLASIHYPSPFFTTIEERGTVPNR-FLFIVMPLYGENLFDLMMNTNKDR
..|||....|.||..||....||.|  .||.|||.   |||.. | ....| .|  | ....|..||.||.|.|| |..|||.|.|.|| ||..|.. ||
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP-DR

KFSMATGLHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIGR---EVDGQHHQVYLLDFGLCKRPRFAKKNDEAEEQMRK-NAIHYRGVVKYASVHAHQGKN
||||.|||..|.|.| ||.|||..||||||.||..|||||   . |..||..|.||||.|.  |....|.. | .... .|...|| |.||....|.|..
KFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCR--RKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQE

LGYKDDMESWWYMVLEFFLGALPWALLNKESEQDVLHLK--RRITAPMVAAVWRTTP--ETTAGFFDLLTVIREPKDVAEFV
...|||.|||.||..|...| |||. ........... .  ||..||| . .....|  |... .. ...  ........|.
QCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase ZK354.2.AA CK1 21-256 27 1e-91 311.0 In-house 1-298 (339) Show / Hide 
Range on Protein: 21-256
Range on HMM: 1-298/339
Sequence Identity: 27% (81 aa)

YEVTKPLATGTFG-SIYKA-----KRESDG-----KFFAVKCEALNMK--SSLLRQMSVVLASIHYP-------------------SPFFTTIEERGTVP
..|.|....| ||  |||.     |.....     ...|.|.|  . .  ...|  ......  ..                    .|.. ...  | ..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

NRFLFIVMPLYGENLFDLMM-NTNKDRKFSMATGLHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIGREV-----------DGQHHQVYLLDFGLCKRPRF
... ..||.|.|.|| ||.. |.. .||||| |.|..|.|.| |....|..|||||||||. ||.||.            ...|.|||..|||...| ..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARR-KY

AKKNDEA----------EEQMRKN---AIHYRG-VVKYASVHAHQGKNLGYKDDMESWWYMVLEFFLGA--LPWALLNKESE----QDVLHLKRRITAPM
..|...           .  ....   .  .||  ..|.|...|.|| .| .||..||.||..|.. |   |||  ...|..    | | . |. ... .
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEK
Kinase ZK354.2.AA TTBKL 21-234 31 1.4e-42 141.64 In-house 1-228 (288) Show / Hide 
Range on Protein: 21-234
Range on HMM: 1-228/288
Sequence Identity: 31% (74 aa)

YEVTKPLATGTFGSIYKAKRESD-GKFFAVKCEALNMKS-SLLRQMSVVLASIHY--PSPFFTTIEERGTVPNRFLFIVMPLYGENLFDLM-MNTNKDRK
....| .. | ||..|...  .| ....|.| |   .   .   .| | . .  .  .||.| .. . |  .. . |.|| | |.|| ||. |. ||.  
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKD-YNFMVMTLCGPNLQDLRKMMPNKK-R

FSMATGLHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIGREVD-GQH-HQVYLLDFGLCKRPRFAKKNDEA-------EEQMRK--N---AIHYRGVVKYA
||  | . .. |.| |....|..||||||.||. .|.| . . .   . |||.|||...  ..|.|..|        . .||.  |       || ..|.
FSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMAR--QYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYC

SVHAHQGKNLGYKDDMESWWYMVLEFFLGALPW
|. .|..| .| .||. || ||. |...| |||
SPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPW
Kinase ZK354.2.AA TTBK 89-234 39 6.2e-34 117.32 In-house 68-207 (257) Show / Hide 
Range on Protein: 89-234
Range on HMM: 68-207/257
Sequence Identity: 39% (58 aa)

NRFLFIVMPLYGENLFDLMMNTNKDRKFSMATGLHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIGREVDGQHHQVYLLDFGLCKRPRFAKKNDEAEEQMR
..| ..|| | |.|| ||  .  .  .||. | | |  | | .|.  |  || ||||||| | .||    .  ..|.|||||    ..   | . |    
DKFNYMVMQLQGKNLADLRRKQPRG-CFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPS-TCRKCYMLDFGLAR--QYT--NACGEVRPP

KNAIHYRGVVKYASVHAHQGKNLGYKDDMESWWYMVLEFFLGALPW
 ..  .|| | |||. ||. ...| .||. |  ||  ||  | |||
REVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPW
Kinase ZK354.2.AA CK1-A 21-234 31 2.3e-31 108.03 In-house 1-205 (261) Show / Hide 
Range on Protein: 21-234
Range on HMM: 1-205/261
Sequence Identity: 31% (67 aa)

YEVTKPLATGTFGSIYKAKRESDGKFFAVKCEALNMKSSLLRQMSVVLASIHYPSPFFTTIEERGTVPNRFLFIVMPLYGENLFDLMMNTNKDRKFSMAT
| . ...  | || || .    .|.  |.| |  . .   |   . |   ..   . . ...  |.  . .  .|| | |  | ||      .|.|.| |
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQG-CVGIPHMRWYGCEKD-YNVMVMDLLGPSLEDLFNFC--KRRFTMKT

GLHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIGREVDGQHHQVYLLDFGLCKRPRFAKKNDEAEEQMRKNAIHYRGVVKYASVHAHQGKNLGYKDDMESW
 | ||.| .. |  .|  .||||||||  | .|  ..    ...|.|||| |. | ..     . .  || .   | ..|||..||.|     .||||| 
VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMG--IGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLT---GTARYASINAHLGIEQSRRDDMESM

WYMVLEFFLGALPW
 |... | .| |||
GYVMMYFNRGKLPW
Kinase ZK354.2.AA CK1-D 94-234 40 1.9e-24 83.06 In-house 72-205 (261) Show / Hide 
Range on Protein: 94-234
Range on HMM: 72-205/261
Sequence Identity: 40% (57 aa)

IVMPLYGENLFDLMMNTNKDRKFSMATGLHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIGREVDGQHHQVYLLDFGLCKRPRFAKKNDEAEEQMRKNAIH
.|| | |  | ||    .  ||||. | | ||.| .. |  .| . ||||||||  | .|  .  . . ||..|||| || | |.          ||   
MVMDLLGPSLEDLFNYCH--RKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMG--LGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLT-

YRGVVKYASVHAHQGKNLGYKDDMESWWYMVLEFFLGALPW
  |  .|||.  |||     .||.||  |... | .|.|||
--GTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPW
Kinase ZK354.2.AA CK1-Unclassified 93-173 48 1.4e-23 66.47 In-house 80-157 (244) Show / Hide 
Range on Protein: 93-173
Range on HMM: 80-157/244
Sequence Identity: 48% (40 aa)

FIVMPLYGENLFDLMMNTNKDRKFSMATGLHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIG-REVDGQHHQVYLLDFGLCKR
..|| | |..| ||.   |  ||||. | | .|.| .. |  ||...||||||||  |..| ..   .|||||. |||| ||
IMVMDLLGPSLEDLFNMCN--RKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGK--NHHQVYIIDFGLSKR
Kinase ZK354.2.AA CK1 113-173 50 4e-21 69.62 In-house 99-158 (271) Show / Hide 
Range on Protein: 113-173
Range on HMM: 99-158/271
Sequence Identity: 50% (31 aa)

DRKFSMATGLHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIGREVDGQHHQVYLLDFGLCKR
.||||. | | .|.| .. |  .| ..||||||||  |..||    ..||||. |||| ||
NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKR
Kinase ZK354.2.AA CK1-Unique 21-236 22 3.2e-20 66.84 In-house 1-234 (337) Show / Hide 
Range on Protein: 21-236
Range on HMM: 1-234/337
Sequence Identity: 22% (55 aa)

YEVTKPLATGTFGSIYKAKRESDG------KFFAVKCEALNMKSS--LLRQMSVVLASIHYPS------PFFTTIEERGTVPNRFLFIVMPLYGENLFDL
. |.| .  | .|  ..   . .|      . .. | |   |.    .|     |...|   .        |  ..  . .     .||| . | ..  .
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFH-QHRDWWWIVMTMHGPSMEEC

MMNTNKDRKFSMATG--------LHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIGREVDGQHHQVYLLDFGLCKRPRFAKKNDEAEEQMRKNAIHYRGVV
 |   . . |..  .        . ...|.| .|.  |  ||.||..||  .| .       |  | ||.| |.|  |  .| .      .  . .||. 
CM---MMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPI--TPFRGCK

KYASVHAHQGKNLGYKDDMESWWYMVLEFFLGA--LPWAL
.|..   || . .| .|||||| || .  ...   | | |
DYCPCSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWKL
Kinase ZK354.2.AA Dual 93-224 32 1.3e-18 59.07 In-house 88-213 (282) Show / Hide 
Range on Protein: 93-224
Range on HMM: 88-213/282
Sequence Identity: 32% (43 aa)

FIVMPLYGENLFDLMM-NTNKDRKFSMATGLHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIGREVDGQHHQVYLLDFGLCKRPRFAK-KNDEAEEQMRKN
..|| .||  | . .   ...   .|| .    | |.|.||.|||  |..||.|||. | .|  .. .   ||..||.. .   .   .| .     ||.
YWVMSPYGPSLQEIRRKYIMG--QLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCG--LGMDETTVYMQDFRIVR--KYIDPENKKH-RTARKK

AIHYRGVVKYASVHAHQGKNLGYKDDMESWWYMV
 . . |   ||.      |  | |||.|.| |||
-VKMYGCGRYACRACMMQKDQGRKDDLECWIYMV
Kinase ZK354.2.AA Pkinase 21-148 21 1.3e-15 56.32 Pfam 1-137 (293) Show / Hide 
Range on Protein: 21-148
Range on HMM: 1-137/293
Sequence Identity: 21% (31 aa)

YEVTKPLATGTFGSIYKAKRESDGKFFAVKCEALNMKSSLLRQMSV------VLASIHYPSPFFTTIEERGTVPNRFLFIVMPLYGE-----NLFDLMMN
|.. ...  |.||. ||... ..|| .|||.  .  ..|  .|  .      ......  .|.  .. .  .  .. . .||.. .       |||... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST

TNKDRKF--SMATGLHLAEQTLTAIRDLHRNGFIHRDIKPS
  ....|  |. .  . . |.| ..  .|..|.||||.||.
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPE
Kinase ZK354.2.AA S_TKc 21-293 14 1.1e-11 -5.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-293
Range on HMM: 1-231/231
Sequence Identity: 14% (44 aa)

YEVTKPLATGTFGSIYKAKRESDGKFFAVKCEALNMKSSLLRQMSVVLASIHYPSPFFTTIEERGTVPNRFLFIVMPLYGE---NLFDLMMNTNKDRK--
||. ...  |.||. ||..  ..|. .|.|.       ...| ...         |.  .. .       .|..|| . .    .|||.. . .. ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FSMATGLHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIGREVDGQHHQVYLLDFGLCKRPRFAKKNDEAEEQMRKNAIHYRGVVKYAS--VHAHQGKNLG
 |.  .  ... |.. |.  .|..|.||||.||.   . .       .. . ||||...                   .. |   | .  |         
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL--------

YKDDM-ESWWY----MVLEFFLGALPWALLNKESEQDVLHLKRRITAPMVAAVWRTTPETTAGFFDLLT--VIREPK---DVAEFVE-------YDRI
 . .  .. |.    .. |.. |  |.         ..  . ..|               .  . |..     ..|.    . |  .          .
-GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ZK354.2.AA CK1-Unclassified 21-61 34 1.8e-07 18.13 In-house 1-41 (244) Show / Hide 
Range on Protein: 21-61
Range on HMM: 1-41/244
Sequence Identity: 34% (14 aa)

YEVTKPLATGTFGSIYKAKRESDGKFFAVKCEALNMKSSLL
|.|.. . .| || |||..   .....|.| |  | |...|
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQL
Kinase ZK354.2.AA CK1-Unclassified 200-234 45 1e-06 15.5 In-house 182-216 (244) Show / Hide 
Range on Protein: 200-234
Range on HMM: 182-216/244
Sequence Identity: 45% (16 aa)

YASVHAHQGKNLGYKDDMESWWYMVLEFFLGALPW
|||. ||.|.  . .||.||  |  . |  | |||
YASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPW
Kinase ZK354.2.AA CK1 200-234 45 2e-06 18.04 In-house 182-216 (271) Show / Hide 
Range on Protein: 200-234
Range on HMM: 182-216/271
Sequence Identity: 45% (16 aa)

YASVHAHQGKNLGYKDDMESWWYMVLEFFLGALPW
|||. .|.|.  . .|||||  |. . |  | |||
YASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPW
Kinase ZK354.2.AA CK1 21-61 30 1.4e-05 15.39 In-house 1-43 (271) Show / Hide 
Range on Protein: 21-61
Range on HMM: 1-43/271
Sequence Identity: 30% (13 aa)

YEVTKPLATGTFGSIYKAKRESDGKF--FAVKCEALNMKSSLL
|.|.. . .| || ||.... ..|..   |.| |  . | ..|
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQL
Kinase ZK354.2.AA CK1-D 21-57 27 0.026621 3.73 In-house 1-37 (261) Show / Hide 
Range on Protein: 21-57
Range on HMM: 1-37/261
Sequence Identity: 27% (10 aa)

YEVTKPLATGTFGSIYKAKRESDGKFFAVKCEALNMK
| . . .  | || ||  .  . .   |.| |..  |
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTK