Gene IRE1 (Human)

IRE1

Species: Human
Alias: IRE1, MGC163279, IRE1P, MGC163277, FLJ30999, ERN1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17q23-q24,

Classification

Group: Other
Family: IRE

Sequence

Name Sequence Type Origin Length Description Download
IRE1.NA RNA Sugen Kinome 4005 None Fasta, JSON
IRE1.AA Protein Sugen Kinome 977 None Fasta, JSON
IRE1.kin_dom Protein Kinase Domain Sugen Kinome 262 None Fasta, JSON

Protein domain

Protein domains of IRE1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ IRE1.AA PQQ 26-57 33 1.8e-07 32.04 SMART 1-33 (33) Show / Hide 
Range on Protein: 26-57
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

VTLPET-LLFVSTLDGSLHAVSKRTGSIKWTLK
 .. .  ...|.| ||.|.|....|| ..|| |
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE1.AA PQQ 31-68 28 0.000218 17.82 Pfam 1-37 (37) Show / Hide 
Range on Protein: 31-68
Range on HMM: 1-37/37
Sequence Identity: 28% (11 aa)

TLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHV
. ..| | || . |.  .|| .||. |..|. .  . .
GDVYVHTWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
PQQ IRE1.AA PQQ 108-140 30 6e-06 27.04 SMART 1-33 (33) Show / Hide 
Range on Protein: 108-140
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

PCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLS
|....||..| | ... .| .|  ||..  |  
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE1.AA PQQ 146-178 18 4e-06 27.55 SMART 1-33 (33) Show / Hide 
Range on Protein: 146-178
Range on HMM: 1-33/33
Sequence Identity: 18% (6 aa)

SLCPSTSLLYLGRTEYTITMYDTKTRELRWNAT
. . . ...|.|.........|.|| ...|...
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE1.AA PQQ 189-221 27 0.001689 18.87 SMART 1-33 (33) Show / Hide 
Range on Protein: 189-221
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

DDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQN
  |...  ..|. .|| . ..|...|.||| ..
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE1.AA PQQ 203-231 24 9.192649 2.4 Pfam 9-36 (37) Show / Hide 
Range on Protein: 203-231
Range on HMM: 9-36/37
Sequence Identity: 24% (7 aa)

DGLVVTVDSESGDVLWIQNYASPVVAFYV
|| .. .| ..|.|.|  .  .|... ..
DGYIYALDADTGKVKWKFKTGPPDWW-PM
PQQ IRE1.AA PQQ 277-308 24 0.180246 8.07 SMART 1-33 (33) Show / Hide 
Range on Protein: 277-308
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

KSKLTP-TLYVGKYSTSLYASPSMVHEGVAVVP
 ... . |.||| |. .|||  .   . .  ..
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
Kinase IRE1.AA IRE 574-832 51 1.2e-177 596.46 In-house 1-292 (292) Show / Hide 
Range on Protein: 574-832
Range on HMM: 1-292/292
Sequence Identity: 51% (149 aa)

KDVLGHGAEGTIVYRGMFDNRD-VAVKRILPECFSFADREVQLLR--ESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQ---------------
...||.|..||.|..|....|. ||||....|...|..||.|.|.  |||.|||||||.|.|.|.||.|.|.|||...||.||||               
NNILGRGCNGTLVFKGIWNGRIPVAVKQMQKEFNPFISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNN

--KDFA----HLG--LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISM--PNAHG-KIKAMISDFGLCKKLAVGRHSFSR--RSGVPGTEGWIAPEM
  |...    ...  .....|..|...||.||||.||||||||||||||.|  ||.|| ....|||||||||.|..||.||.|  |||..||.||..|||
NNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNRFMISDFGLCKMLVEGRYSFTRNIRSGPTGTWGWHPPEM

LSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFG-KSLQRQANILLGACSLDCLHPEKHED-VIARELIEKMIAMDPQKRPSAKHVLKHPFF
|.|.|....|..|||||.|||||||...|.|||| ..|.|||||| |...||.|....|.. |||..||..||..||||||..|..|.||||
LQEFCQKRKTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYNLDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKECLNHPFF
Kinase IRE1.AA S_TKc 571-832 25 5.4e-56 193.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 571-832
Range on HMM: 1-231/231
Sequence Identity: 25% (72 aa)

FCPKDVLGHGAEGTIVYRGMFDN--RDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA---TLQEYVEQKDFAH----L
.   ...|.|| |. ||..   .  | ||.|.|       . ||.|.|..   |||..... .  | .. |.  |.|     .| .| ...        .
YEILRKIGKGAFGK-VYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

GLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTY-TVDIFSA
  .   ...|. ..|...||..|.|||||| |||..          .|.||||...|          . . ||  ..|||.|        ..  .|. | 
PEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----------TTFCGTPWYMAPEVL------GYGKCKCDWWSC

GCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLK-------HPFF
||..|  .. |  ||   .|.  ....              .  |...|.|.  .||.|||.|  .|.       ||.|
GCILYEMLC-GYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRE1.AA Ciliate-E2 477-832 18 2.8e-42 142.91 In-house 25-365 (365) Show / Hide 
Range on Protein: 477-832
Range on HMM: 25-365/365
Sequence Identity: 18% (83 aa)

QQFQKELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDV
.||.. ... |.. |.||                                                                                  
KQFAIKIID-QKQ-QRQQ----------------------------------------------------------------------------------

LGHGAEGTIVYRGM---FDNRDVAVKRILPECFSFADREVQLLR---------------ESDEHPNVIRYF--CTEKDRQFQYIAIELCAA-TLQEYVEQ
             |   ...  .|.|.. .    .  .| ...|               |.. |||.|...    |||..  |.  |.|   .|..| ..
-------------MQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKN

KDFAHLGL----------EPITLLQQTTS---------------GLAHLHSLN-IVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAV----GRHSF
..  ..            | ... .| ..               .| .||| | |.|||.|| |||.            |.||||.||.      ..| .
NKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTH-K

SRR---------SGVPG----------------TEGWIAPEMLSEDCKEN------PTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDC
...         |. ||                | |  |||.|.    .|       .| .||.|.|...|. .. | .||      | .|. . ....|
QQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF-GKPPF------QQQIKQCKIDFPC

LH-------------PEKHEDVIARELIEK----MIAMDPQKRPS-AKHVLKHPFF
 .               |. .  .  || |    |.  ||.||.. .. .|.||.|
PEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase IRE1.AA Pkinase 571-832 24 5.5e-42 149.53 Pfam 1-293 (293) Show / Hide 
Range on Protein: 571-832
Range on HMM: 1-293/293
Sequence Identity: 24% (75 aa)

FCPKDVLGHGAEGTIVYRGMFDNRD--VAVKRILPECFSFADR-------EVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-----TLQEYVE--
.. . ..| |. |.  |...  .    ||||.|  .  .   .       |.|....   |||..|....  |..  |.  |.|        | .|..  
YHIGRKIGSGSFGCV-YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

-QKDFAHLGLEPI-TLLQQTTSGLAHLHSLNIVHRDLKPHNILIS---MPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKE
 .. |  .  . .   . |. .||...|| .|.|||||| ||||.    ..|    .  |.||||.|..     . |  ... || ...||| . .. . 
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

NPTYTVDIFSAGCVFYYVISEGSHPFGKS--------LQRQANILLGACSLDCLHP------------------EKHEDVIARELIEKMIAMDPQKRPSA
  .. ||..|.||..|.... |  ||  .        .|. ..|. .  . |.  .                  . .|.  ....|......||.|||.|
--GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE--CKDFIKWCLCKDPKKRPTA

KHVLKHPFF
...|.||.|
EQILQHPWF
Kinase IRE1.AA CAMK 576-832 17 2.6e-37 117.29 In-house 1-425 (425) Show / Hide 
Range on Protein: 576-832
Range on HMM: 1-425/425
Sequence Identity: 17% (75 aa)

VLGHGAEGTIVYRGMFDNRD--------------VAVKRIL-------------------------------PECFSFADREVQLLRESDE------HPN
.||.|. | .|....  |                ||.| |                                |.   .  ||.....   .      |||
TLGRGSFG-KVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VIRYFC---------------TEKD-----RQFQYIAI---ELCAAT-----LQEYVEQKDF-------------AHL-GLEPITLLQQTTSGLAHLHSL
.|. .                | ..     ... |.     |.|        | .|. ..                ..   |  .. .|  |.....||.
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

NIVHRDLKPHNILISMPNAHGK------------IKAMISDFGLCKKLAVGRHSF--------------------SRRSGVPGTEGWIA-PEMLSE----
||||||||| |||..  | .               .  |.|||. .|.  |  .|                       . . || . .| ||.|.     
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------DCKENP-TYTVDIFSAGCVFYYVISEGSHPFGKS---------------LQRQANILLGACSLDCLH--------------------PEKHEDV
      |... . .. .|. |.|.. |   . |  ||  .                .   .|. | .. .  .                    .. . . 
NMQNATDEEKPYYGPKCDMWSCGVILYIMLC-GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQ

IARELIEKMIAMDPQKRPSAKHVLKHPFF
 .. || ||   ||.||.... .|.||..
ECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase IRE1.AA Ciliate-E2-Unclassified 471-832 15 1.8e-29 99.43 In-house 40-352 (352) Show / Hide 
Range on Protein: 471-832
Range on HMM: 40-352/352
Sequence Identity: 15% (67 aa)

QQQLQHQQFQKELEKIQLLQQQ-----QQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVI
|.| .... .. .|.... ...                                                                              
QKQIMNKD-EIMNEMKEMNNKKKYHQRK------------------------------------------------------------------------

VGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQ-LLRESDEHPNVIRYFCTEKDRQFQYIAIELC-AATLQEYVEQKDF-----
                                            ... | .|. .. ||.....| ...|.|  ||  |.|   .|..| ... .     
------------------------------------------Y-NKIMQQILLNHP-HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKG

----------AHLGLEPI------TLLQQTTSGLAHLHSLN-IVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAV---------------GRHSFS
           ..  . .      ... |  .|| .||. | |.|||.|| |||..  .   . .  |.|||..||.                  .. ..
NDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMW

RRSGVPGTEGWI--APEMLSEDCKENPT-YTVDIFSAGCVFYYVISEGSHPFG---KSL---------------QRQANILLGACSLDCLHP---EKHED
 ..| |..      |||.| .   .... | .||.| |...|. .    .||.   .                 | . ||. . .. ..  .    || .
TFCGTPNYMP-QYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWS

VIARELIE----KMIAMDPQKRPSAKHVLKHPFF
  | ..|.    ||.  .| ||.... .|.||.|
PEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase IRE1.AA ULK 571-766 23 5.5e-28 94.82 In-house 1-248 (329) Show / Hide 
Range on Protein: 571-766
Range on HMM: 1-248/329
Sequence Identity: 23% (60 aa)

FCPKDVLGHGAEGTIVYRGM---FD---NRDVAVKRIL--PECFSF-----------ADREVQLLRESD-------EHPNVIRYFCTEKDRQF--QYIAI
.| ...||.|. |  ||.|     .   | .||.| |.   .  .             ..|...... .        |||.....   .. ..   ||  
YCLNHCLGKGSFG-KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

ELCAA-TLQEYVEQKDFAHLGLEP-----------ITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAH---------GKIKAMISDFGLCKKLAVG
|.|   .|..| ...   .|...            |  ..|  .|. .||. ||.|||.|| ||||. ....         | .|  |.|||..|..  .
EYCNGGDLEQYIKKN--KKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLK--IADFGFAKHVDND

------RHSFS-RRSGVP---GTEGWIAPEMLSED-CKENPT-YTVDIFSAGCVFYY
       ....          ||    ||. |..   ..... |..||.| ||.||.
NMEQQMMMTCVNE----KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYE
Kinase IRE1.AA TKL 577-830 16 6e-28 97.72 In-house 1-364 (364) Show / Hide 
Range on Protein: 577-830
Range on HMM: 1-364/364
Sequence Identity: 16% (62 aa)

LGHGAEGTIVYRGMFDN----------RDVAVKRILPE----------------------------CFSFADREVQLLRESDE-HPNVIRYFCTEKDRQF
.| |. | .||.| . .          .|||||..  .                            .. .  .|....  |   |||....    .. ..
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------QYIAIELC-AATLQEYVEQKDFAHLGLEP--ITLLQQTTSGLAHLHSLN--------IVHRDLKPHNILISMPNAH---------GK
              .|  |.|   .| .|.           .  . . ... .|...||| |        |.|||||..|||.   . .           
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

IKAMISDFGLCKKLAVGRHSFS----------------RRSGVPGTEGWIAPEMLSEDCK-------------ENPTYTVDIFSAGCVFYYVIS--EGSH
... |.||||.. .    ..                  ... . || .| |||.| .. .             .  .  .|..| | |.. ...  .   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

PF--GKSLQRQ---------ANILLGACSLDCL---------HPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHP
|.   .. ...         . . .  . . .           |... .   ..|...  ..||.||||.. .||. 
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRE1.AA STE 571-763 19 4.6e-26 89.08 In-house 1-257 (359) Show / Hide 
Range on Protein: 571-763
Range on HMM: 1-257/359
Sequence Identity: 19% (54 aa)

FCPKDVLGHGAEGTIVYR-----------GMF-----DNRDVAVKRIL--------------------PECFSFADREVQLLRESDE-HPNVIRYFCTEK
.   ...|.|| || ..            |        .. .|.|..                     .| .    .|........  |||...|.... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

D-------RQFQYIAIELCAA-TLQEYVEQKDFAHLGL-----------EPIT--LLQQTTSG-LAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISD
.       ..  .|. |.... .| . ...|     .|           |..    ..|.  | |..|||..|.|||.|| |||.          . ..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCD

FGLCKKLAV---GRHSFS------------RRSGVPGTEGWIAPEMLSE-DCKEN-PTYT--VDIFSAGCV
||.|..|.    .  . |            .|  . ||  | |||...  ... . . |.  .|| | ||.
FGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCT
Kinase IRE1.AA CMGC 571-718 18 4.5e-25 78.53 In-house 1-254 (513) Show / Hide 
Range on Protein: 571-718
Range on HMM: 1-254/513
Sequence Identity: 18% (47 aa)

FCPKDVLGHGAEGTIVYRGMF----------------DNRDVAVKRIL-PECFS-FAD-------------REVQLLRES----------------DEHP
.   ...|.|. | .||..                  .|. ||.|.|  |. .   |              ||...|..                 . |.
YEIIKKIGEGTYG-VVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

NVI--RYFCTEKD---------------RQFQYIAIELCAATLQEYVEQKDF-----AHLGLEPIT---------------LL------QQTTSGLA--H
|..  ..... |.                .  |.  |..  .| .| ... |       ..|..                 ..      .|   ||.  .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSLN--IVHRDLKPHNILISMPNAH-----------------GKIKAMISDFGLCKKL
.|| .  |.|||||| ||||.  .                   |..|  | ||||....
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLK--ICDFGLARWY
Kinase IRE1.AA ULK 571-766 25 3.1e-24 82.91 In-house 1-244 (324) Show / Hide 
Range on Protein: 571-766
Range on HMM: 1-244/324
Sequence Identity: 25% (63 aa)

FCPKDVLGHGAEGTIVYRG--MFD---NRDVAVKRILPECFSFA-------------DREVQLLRESDE--HPN--VIRYFCTEKDR--QFQYIAIELCA
.| ...||.|. |  ||.|  . .   | .||.| |    ..               ..|.|.... .|  |||  .....   ..    . ||  |.| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

A-TLQEYVEQKDFAHLGL---------EPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAH---------GKIKAMISDFGLCKKLAVG-RHSFS
  .|..| ...    .           | |  ..|  .|. .||. ||.|||.|| ||||. ....         | .|  |.|||..|..  .    . 
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLK--IADFGFAKHVDNNNMEQQM

RRSGVP-----GTEGWIAPEMLSED-CKENPT-YTVDIFSAGCVFYY
. . |      ||    ||. |..   ..... | .||.| ||.||.
CQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYE
Kinase IRE1.AA Ciliate-E2a 611-765 29 9.7e-23 63.78 In-house 48-207 (275) Show / Hide 
Range on Protein: 611-765
Range on HMM: 48-207/275
Sequence Identity: 29% (49 aa)

REVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLG-LEPITLLQQTTS-GLAHLHSLNIVHRDLKPHNILIS--MPNAHGKI
.|....|.   |||.|. . . .| .  |.  |.|   .| ..  |..       |   ..|| .. ||...|..||.|||||| |||.    .|   . 
NEINIMRQL-DHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNS

KAMISDFGLCKKL--AVGRHSFSRRSGVPGTEGWIAPEMLSEDCK-ENPTYT--VDIFSAGCVFY
. .|.|||| ..     ..  |..     || | .||| |    . ... |.  .|..|.|..||
DIKIIDFGLATFIDKDEKKYMFQKC----GTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFY
Kinase IRE1.AA TyrKc 571-832 21 1.6e-12 -20.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 571-832
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

FCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFAD--REVQLLRES-DEHPNVIRYF--CTEKDR-----QFQYIAIELCAA-TLQEYV-EQKDF
   ...||.|| | .||.|. . ..|||| . ...   .|  || .....   .|||..| .  ||.. |     .  .|  |...   |..|  . .. 
ITLGKKLGEGAFG-EVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

AHLGLEPITLLQ---QTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVG--------RHSFSRRSGVP--GTEGWIAPEMLSE
    | . .||.   |  .| ..||| |..||||   |.|.. ..      . ||||||....  .          . . ..|        | ||| .  
----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

DCKEN-PTYTVDIFSAGCVFYYVISEGSHPFG------KSLQRQANILLGACSLDCLHP-------EKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPF
  ...  |   |..| | . . . . |  |        .| |.  . .     ... .        . ....    ....  . || .||. . .  | .
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ--IMKQCWHEDPEDRPTFSEI--HEC

F
|
F
Kinase IRE1.AA CMGC 797-832 41 6.4e-12 34.51 In-house 478-513 (513) Show / Hide 
Range on Protein: 797-832
Range on HMM: 478-513/513
Sequence Identity: 41% (15 aa)

PEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFF
..|..|  |..|..||  .||.||..|.  |.||.|
KRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase IRE1.AA Ciliate-E2a 805-832 42 1.1e-10 27.71 In-house 248-275 (275) Show / Hide 
Range on Protein: 805-832
Range on HMM: 248-275/275
Sequence Identity: 42% (12 aa)

ARELIEKMIAMDPQKRPSAKHVLKHPFF
.  |. ||   ||.||..|.  |.||.|
CKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase IRE1.AA STE 806-832 44 4e-07 21.33 In-house 331-359 (359) Show / Hide 
Range on Protein: 806-832
Range on HMM: 331-359/359
Sequence Identity: 44% (13 aa)

RELIEKMIAMDPQKRPSAKHVLK--HPFF
.. |.|   .||.|||.|.  ||  |||.
KDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase IRE1.AA ULK 806-832 33 0.007898 5.81 In-house 303-329 (329) Show / Hide 
Range on Protein: 806-832
Range on HMM: 303-329/329
Sequence Identity: 33% (9 aa)

RELIEKMIAMDPQKRPSAKHVLKHPFF
..|| .|.  |. .| |   ...||.|
KDLIRRMLQYDEKDRISWEELFNHPWF
Kinase IRE1.AA ULK 806-832 33 0.008992 5.74 In-house 298-324 (324) Show / Hide 
Range on Protein: 806-832
Range on HMM: 298-324/324
Sequence Identity: 33% (9 aa)

RELIEKMIAMDPQKRPSAKHVLKHPFF
..|| .|.  |. .| |   ...||.|
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase IRE1.AA CMGC 752-765 42 0.044093 1.59 In-house 313-326 (513) Show / Hide 
Range on Protein: 752-765
Range on HMM: 313-326/513
Sequence Identity: 42% (6 aa)

TYTVDIFSAGCVFY
|...|. |.||.|.
TTPIDMWSVGCIFA
Ribonuc_2-5A IRE1.AA Ribonuc_2-5A 837-963 51 7.1e-76 263.18 Pfam 1-137 (137) Show / Hide 
Range on Protein: 837-963
Range on HMM: 1-137/137
Sequence Identity: 51% (71 aa)

KQLQFFQDVSDRIEKESLD--GPIVKQLERGGRAVVK-MDWRENITVPLQTDLRKF-RT---YKGGSVRDLLRAMRNKKHHYREL-PAEVRETLGSLPDD
|.|.|..|||||.|.|. |   ||.. |||..|.||. .||...|  ....|..|. |.   |.|.||||||||||||||||.|. |.|..|.||.|||.
KRLRFLCDVSDRFEIEDRDPPSPILQALERTSRCVVGFGDWHKKIDKAFMDDMGKYYRKRKNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLPDG

FVCYFTSRFPHLLAHTYRAME--LCSHERLFQPYYFH
|..|||.|||||| |.|..|.   |.||..|..|| .
FLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYKP
PUG IRE1.AA PUG 895-952 40 1e-26 95.98 SMART 1-66 (66) Show / Hide 
Range on Protein: 895-952
Range on HMM: 1-66/66
Sequence Identity: 40% (27 aa)

GSVRDLLRAMRNKKHHYREL--------PAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCS
 |||||||.|||..||.||.        .....|..|..|..| ||||..||.|. |.. ....|.
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK