Gene IRE2 (Human)

IRE2

Species: Human
Alias: IRE2, ERN2, IRE1b
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , GeneCards
Annotation: Consensus chromosomal location: 16p12.1-p13.1,

Classification

Group: Other
Family: IRE

Sequence

Name Sequence Type Origin Length Description Download
IRE2.NA RNA Sugen Kinome 3634 None Fasta, JSON
IRE2.AA Protein Sugen Kinome 926 None Fasta, JSON
IRE2.kin_dom Protein Kinase Domain Sugen Kinome 262 None Fasta, JSON

Protein domain

Protein domains of IRE2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ IRE2.AA PQQ 34-65 33 1e-06 29.46 SMART 1-33 (33) Show / Hide 
Range on Protein: 34-65
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

TLRPEN-LLLVSTLDGSLHALSKQTGDLKWTLR
. . .. .. |.| ||.|.||.. ||...|| .
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE2.AA PQQ 39-76 28 0.000387 16.99 Pfam 1-37 (37) Show / Hide 
Range on Protein: 39-76
Range on HMM: 1-37/37
Sequence Identity: 28% (11 aa)

NLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYV
. . | | || . ||   ||..||. . .|.. . . .
GDVYVHTWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
PQQ IRE2.AA PQQ 116-148 24 0.000581 20.41 SMART 1-33 (33) Show / Hide 
Range on Protein: 116-148
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

PCRSSDGVFYTGRKQDAWFVVDPESGETQMTLT
|....||. |.|.... .. .|...|.   | .
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE2.AA PQQ 149-181 12 0.043831 12.78 SMART 1-33 (33) Show / Hide 
Range on Protein: 149-181
Range on HMM: 1-33/33
Sequence Identity: 12% (4 aa)

TEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTT
.   .   .|.|........ |..   ..|. .
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE2.AA PQQ 193-224 24 0.002668 18.21 SMART 1-33 (33) Show / Hide 
Range on Protein: 193-224
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

SPGKYM-SHLASCGMGLLLTVDPGSGTVLWTQD
.. ...  . .... | | ..|. .| ||||..
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
Kinase IRE2.AA IRE 523-781 45 1.6e-163 549.57 In-house 1-292 (292) Show / Hide 
Range on Protein: 523-781
Range on HMM: 1-292/292
Sequence Identity: 45% (134 aa)

KDVLGRGAGGTFVFRGQFEGRA-VAVKRLLRECFGLVRREVQLLQ--ESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVEN---------------
...||||..||.||.|...||. ||||....|.. ...||.|.|.  |||.||||.||.|.|...||.|.|||||..|||.|||.               
NNILGRGCNGTLVFKGIWNGRIPVAVKQMQKEFNPFISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNN

--PDLD----RGG--LEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITG--PDSQG-LGRVVLSDFGLCKKLPAGRCSFSL--HSGIPGTEGWMAPEL
  ....    . .  .... ...|.|.||.||||..|||||||| ||||.   |...|  .|...|||||||.|..||.||.   .||..||.||..||.
NNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNRFMISDFGLCKMLVEGRYSFTRNIRSGPTGTWGWHPPEM

LQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFG-DSLYRQANILTGAPCLAHLEEEVHDK-VVARDLVGAMLSPLPQPRPSAPQVLAHPFF
|| ......|..|||||.|||||||...|.|||| |.|.||||||.|...|..|... |.. |.|.||. .|... || ||.. ..|.||||
LQEFCQKRKTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYNLDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKECLNHPFF
S_TKc IRE2.AA S_TKc 520-781 24 5.5e-56 193.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 520-781
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

FNPKDVLGRGAGGTFVFRGQFEG--RAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRA---SLQEYVENPDLDRGG--L
.   ...|.|| |. |....  .  | ||.|..       .|||.|.|..  .|||. ... . .  .. |. .|.|     .| .| ..    ...  .
YEILRKIGKGAFGK-VYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

EPEVV---LQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTS-AVDIFS
 . ..   ..|. ..|...||..|.|||||| |||..        .. ..||||...|          . . ||  .||||.|      . .  ..|. |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----------TTFCGTPWYMAPEVL------GYGKCKCDWWS

AGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLA-------HPFF
 ||..|  |. |  ||   ...  ...                  |.|..  .|   |. ||.| ..|.       ||.|
CGCILYEMLC-GYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase IRE2.AA Pkinase 520-781 24 7.9e-41 145.45 Pfam 1-293 (293) Show / Hide 
Range on Protein: 520-781
Range on HMM: 1-293/293
Sequence Identity: 24% (76 aa)

FNPKDVLGRGAGGTFVFRGQFEGRA--VAVKRLLRECFGL-----VRR--EVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRA-----SLQEYVENP
.  . ..|.|. |. |....  |    ||||.. ..          ||  |.|....  .|||..|.... . ..  |. .|.|.      .| .|..  
YHIGRKIGSGSFGC-VYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

DLDRGGL--EPEVV---LQQLMSGLAHLHSLHIVHRDLKPGNILIT---GPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPP
  ..|..  .....   . |. .||...||  |.|||||| ||||     .|.    .| ..||||.|..     . |  ... || ..||||...    
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR----

DSP--TSAVDIFSAGCVFYYVLSGGSHPFGDS-----LYRQANILTGAPCLAHLEEEVHDK-------------------VVARDLVGAMLSPLPQPRPS
...  ...||..|.||..|..|. |  || ..     .  .. |    ..  | ...  .                      ..|..  .| . |. ||.
GGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

APQVLAHPFF
|.|.| ||.|
AEQILQHPWF
Kinase IRE2.AA CAMK 525-781 17 3.7e-39 123.34 In-house 1-425 (425) Show / Hide 
Range on Protein: 525-781
Range on HMM: 1-425/425
Sequence Identity: 17% (77 aa)

VLGRGAGGTFVFRGQFE-G-------------RAVAVKRLLRE-------------------------------CFGLVRREVQLLQESD------RHPN
.||||. |. |....                 . ||.| . ..                                   ||||.....         .|||
TLGRGSFGK-VKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VLRYFC---------------TERG-----PQFHYIALELCRASLQEYVENPDL--D-------RGG---------------L-EPE--VVLQQLMSGLA
... .                | .      ... |. .|       ||... .|  |       .|.               . | |   . .|. |...
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVME-----IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVH

HLHSLHIVHRDLKPGNILITGPDSQGL------------GRVVLSDFGLCKKLPAGRCSF--------------------SLHSGIPGTEGWMA-PELLQ
..||..|||||||| |||..  ..               . . ..|||. .|.. |  .|                     . .   || . || ||.|.
YCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN

L-------------LPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDS---------------LYRQANILTGAPCLAHL-------------EEEVHDK-
               |...|  ..|. |.|.. |  |.|   || ..                    .|..|     .                .. |  
GKGHCNMQNATDEEKPYYGP--KCDMWSCGVILYIMLCG-YPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEF

-----VVARDLVGAMLSPLPQPRPSAPQVLAHPFF
       ..||.  || . |. |... |.|.||..
HHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase IRE2.AA Ciliate-E2 565-781 19 1.5e-32 109.01 In-house 85-365 (365) Show / Hide 
Range on Protein: 565-781
Range on HMM: 85-365/365
Sequence Identity: 19% (62 aa)

LQESDRHPNVLRYF--CTERGPQFHYIALELCRA-SLQEYVE--------------NPDLDRGGLEPEVVLQ-----------QLMSGLAHLHSLH-IVH
..|.. |||.....    |   .  |. .|.|   .|..| .              ....   .   . .||           .....| .||| . |.|
ILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH

RDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRC----------------------------SFSLHSGIPGTEGWMAPELLQLLPPDS------PT
||.|| |||.          . ..||||.||.   ..                            .. ..  | || | |||| |.  . |        .
RDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD

SAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD-KVVAR--------------------------DLVGA----MLSPLPQPRP
 ..||.|.|...|. |.|  .||                    ... .. |.  .                          ||       ||   |. |.
YKCDIWSLGVILYEMLFG-KPPF--------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI

S-APQVLAHPFF
. . |.| ||.|
TGWEQILNHPWF
Kinase IRE2.AA STE 520-712 21 4.2e-29 99.97 In-house 1-257 (359) Show / Hide 
Range on Protein: 520-712
Range on HMM: 1-257/359
Sequence Identity: 21% (59 aa)

FNPKDVLGRGAGGTFVFR-----------GQF-----EGRAVAVKRL-LREC-------------------FGLVRREVQLLQESDR-HPNVLRYFCTER
.   ...|.||.|| .             |.       |. .|.|.. |..|                   .  . .|........  |||. .|.... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GP-------QFHYIALELCRA-SLQEYVENPDLDRGGL-----------EPEV--VLQQLMSG-LAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSD
         .  .|..|.. . || . ...     ..|           |...  ...|.  | |..|||.||.|||.||.|||.          | |.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCD

FGLCKKLPA---GRCSFS------------LHSGIPGTEGWMAPELLQLLPPD--SPTS-AVDIFSAGCV
||.|..|     .  . |                . ||  ||||| .|    .  .. .  .|| | ||.
FGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCT
Kinase IRE2.AA TKL 526-714 18 1e-27 96.92 In-house 1-280 (364) Show / Hide 
Range on Protein: 526-714
Range on HMM: 1-280/364
Sequence Identity: 18% (53 aa)

LGRGAGGTFVFRGQFEG----------RAVAVKRLLR---ECFGL-------------------------VRREVQLLQESD-RHPNVLRYFCTERGPQF
.|.|. |  |..|.. |          . ||||.. .    .| .                          ..|..... |  ||||....      |..
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------HYIALELC-RASLQEYVENPDLDRGGLEPEVVLQ---QLMSGLAHLHSLH--------IVHRDLKPGNILITGPDS---------QG
             ..|  |.| . || .|.           ... ..   .  .|...||| .        |.|||||. |||.              . 
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

LGRVVLSDFGLCKKLPAGRCSFSL----------------HSGIPGTEGWMAPELLQLLPPDS-------------PTSAVDIFSAGCVFY
 ... ..||||.. .     .                   .. . || .|||||.|.  ....              . ..|..| | |..
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW
Kinase IRE2.AA Ciliate-E2-Unclassified 563-781 21 2e-26 88.65 In-house 69-352 (352) Show / Hide 
Range on Protein: 563-781
Range on HMM: 69-352/352
Sequence Identity: 21% (63 aa)

QLLQE---SDRHPNVLRYFCTERGPQFHYIALELCRA-SLQEYVEN-PD------------LDRGGLEPEVVL--------QQLMSGLAHLHSLH-IVHR
...|.   .  ||.....| ...  |  || .|.|.  .|..| .. .             . |  .. . ..         |. .|| .||. . |.||
KIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHR

DLKPGNILITGPDSQGL-GRVVLSDFGLCKKLP------------AGRCSFSLHSGIPGTEGWM----APELLQLLPPDSPTS-AVDIFSAGCVFYYVLS
|.|| |||.   |..|  ... ..|||..||.              .. .. . . . || . |    |||.||   .| ... ..||.| |...|. | 
DIKPENILF---DNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF

GGSHPFGD-SLYR----------------QANILTGAPCLAHLEEE--VHDKVV--ARDLVG----AMLSPLPQPRPSAPQVLAHPFF
|  .||.| . .                 . ..    ..    ...  .....   | |..      ||   |  |....|.| ||.|
GY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase IRE2.AA Ciliate-E2a 617-719 29 2.4e-24 68.57 In-house 106-212 (275) Show / Hide 
Range on Protein: 617-719
Range on HMM: 106-212/275
Sequence Identity: 29% (35 aa)

VLQQLMS-GLAHLHSLHIVHRDLKPGNILIT--GPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIP-------GTEGWMAPELLQLLPPD---SP--T
..||| . ||...|...|.|||||| |||..   ..|. .  ....|||| .. .           ..       || | .|||.| .  ..   ..  .
IMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD---------EKKYMFQKCGTPGYVAPEVLNN--KEVLKHKQYD

SAVDIFSAGCVFYYVLSG
  .|..|.|..||  |.|
TKCDMWSCGVIFYILLCG
Kinase IRE2.AA ULK 520-719 21 3.9e-24 81.19 In-house 1-252 (329) Show / Hide 
Range on Protein: 520-719
Range on HMM: 1-252/329
Sequence Identity: 21% (56 aa)

FNPKDVLGRGAGGTFVFRGQ---FE---GRAVAVKRLLRE--CFGL-----------VRREVQLLQESD-------RHPNVLRYFCTERGPQF--HYIAL
.. ...|| |. |  |..|     .   . .||.| ....     .           ...|...... .       .|||. ...   . ...  .|| .
YCLNHCLGKGSFG-KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

ELCRA-SLQEYVENPDLDRGGLEPE------------VVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPD--------SQGLGRVVLSDFGLCKKLPAG
|.|    |..| ..   ...  |..             ...|...|. .||.  |.|||.|| ||||. ..         .  |.. ..|||..|..  .
EYCNGGDLEQYIKK---NKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDND

---RCSFSLHSG---IPGTEGWMAPELLQLL----PPDSPTSAVDIFSAGCVFYYVLSG
      .   ..   . ||   |||..|| .    |...  . .||.| ||.||. | |
NMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYD--YKCDIWSLGCIFYEMLYG
Kinase IRE2.AA CMGC 520-667 15 1.4e-21 66.9 In-house 1-254 (513) Show / Hide 
Range on Protein: 520-667
Range on HMM: 1-254/513
Sequence Identity: 15% (41 aa)

FNPKDVLGRGAGGTFVFRGQF----------------EGRAVAVKRLLRECFGLVR---------------REVQLLQES----------------DRHP
.   ...|.|. |  |....                  .. ||.|.. ..                     ||...|..                 . |.
YEIIKKIGEGTYG-VVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

NVL--RYFCTERGPQ---------------FHYIALELCRASLQEYVE-NPDLDRG----GLEPEV---------------VL------QQLMSGLA--H
|..  ..... ....                 |.  |..  .| .| . |.....|    .|.. .                .      .|.  ||.  .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSLH--IVHRDLKPGNILITGPDSQ---------------GLGRVVLSDFGLCKKL
.||    |.|||||| ||||.                      ||. . ||||....
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWY
Kinase IRE2.AA RSK 616-721 31 6.3e-19 66.08 In-house 108-210 (278) Show / Hide 
Range on Protein: 616-721
Range on HMM: 108-210/278
Sequence Identity: 31% (35 aa)

VVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCS--FSLHSGIPGTEGWMAPELLQ-LLPPDS-PTSAVDIFSAGC
... .. . . |||...|.|||||| ||| .  .  . |...|.|||.||..   ||.  . ...   .|   ||||.|     ...  . |.|..| |.
FYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES--NEGHIKLTDFGFCKQF---RCDHNQWTMT-FCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLGV

VFYYVLSGGS
. |  |.| .
LMYEMLTGCP
Kinase IRE2.AA TyrKc 520-781 21 5.1e-11 -44.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 520-781
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

FNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQES-DRHPNVLRYF--CTERGP-----QFHYIALELCRA-SLQEYVENPDLDRG
   ...||.|| |. |..|.   . |||| |  ..    .|| ... .   .|||..| .  ||. |      . ..| .|..   .|..|  ..  .  
ITLGKKLGEGAFGE-VYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

GLEPEVVLQ---QLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAG--------RCSFSLHSGIP--GTEGWMAPELLQLLPP
 | ..  |.   |  .| ..||| ...||||   |.|.. .      .|  |||||....  .          . . |.|        ||||| .     
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----

DSP--TSAVDIFSAGCVFYYVLSGGSHPFGD------SLYRQANILTGA---PCLAHLEEE-----VHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFF
.    |.. |..| | . . ... |  |  .      | ..  . .      |. .. . .      .|..    .        |  ||.  ..  | .|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQ--IMKQCWHEDPEDRPTFSEI--HECF
Kinase IRE2.AA RSK 754-781 33 1e-06 20.58 In-house 246-278 (278) Show / Hide 
Range on Protein: 754-781
Range on HMM: 246-278/278
Sequence Identity: 33% (11 aa)

ARDLVGAMLSPLPQPRPS-----APQVLAHPFF
|.||. .||   |. |..     | ....||.|
AKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase IRE2.AA Ciliate-E2a 754-781 42 1e-06 15.57 In-house 248-275 (275) Show / Hide 
Range on Protein: 754-781
Range on HMM: 248-275/275
Sequence Identity: 42% (12 aa)

ARDLVGAMLSPLPQPRPSAPQVLAHPFF
. ||.  || . |. |..| | | ||.|
CKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase IRE2.AA CMGC 754-781 46 1.6e-05 13.08 In-house 486-513 (513) Show / Hide 
Range on Protein: 754-781
Range on HMM: 486-513/513
Sequence Identity: 46% (13 aa)

ARDLVGAMLSPLPQPRPSAPQVLAHPFF
|.||.  ||   |. |..| | |.||.|
AIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase IRE2.AA STE 769-781 53 0.019432 4.57 In-house 345-359 (359) Show / Hide 
Range on Protein: 769-781
Range on HMM: 345-359/359
Sequence Identity: 53% (8 aa)

RPSAPQVLA--HPFF
||.| | |   |||.
RPTASQLLKSEHPFI
Kinase IRE2.AA CMGC 701-720 29 0.034421 1.95 In-house 313-339 (513) Show / Hide 
Range on Protein: 701-720
Range on HMM: 313-339/513
Sequence Identity: 29% (8 aa)

TSAVDIFSAGCVFYYVLSG-------G
|...|. |.||.|.  . |       |
TTPIDMWSVGCIFAEMYTGYQSLIFRG
Ribonuc_2-5A IRE2.AA Ribonuc_2-5A 786-912 46 2.8e-74 257.87 Pfam 1-137 (137) Show / Hide 
Range on Protein: 786-912
Range on HMM: 1-137/137
Sequence Identity: 46% (64 aa)

KQLQFFQDVSDWLEKESEQ--EPLVRALEAGGCAVVR-DNWHEHISMPLQTDLRKF-RS---YKGTSVRDLLRAVRNKKHHYREL-PVEVRQALGQVPDG
|.|.|..||||..|.|. .  .|...|||.....||. ..||..|  ....|..|. |.   |.|.|||||||| |||||||.|. | |... ||..|||
KRLRFLCDVSDRFEIEDRDPPSPILQALERTSRCVVGFGDWHKKIDKAFMDDMGKYYRKRKNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLPDG

FVQYFTNRFPRLLLHTHRAMR--SCASESLFLPYYPP
|.||||.|||.||.|....|.   |. |..| .||.|
FLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYKP
PUG IRE2.AA PUG 844-899 39 3.3e-22 81.01 SMART 1-66 (66) Show / Hide 
Range on Protein: 844-899
Range on HMM: 1-66/66
Sequence Identity: 39% (26 aa)

TSVRDLLRAVRNKKHHYREL--------PVEVRQALGQVPDGFVQYFTNRFPRLLL--HTHRAMRS
.|||||||..||..||.||.        . .... .||||.|| .||| .||.|..  ..| .. .
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK