Gene 26110 (Tetrahymena)
26110
Group:
Other
Family:
Ciliate-C3
Sequence
Protein domains of 26110.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 26110.AA | Ciliate-C3 | 717-850 | 72 | 2.9e-81 | 276.31 | In-house | 1-140 (140) | Show / Hide |
Range on Protein: 717-850 Range on HMM: 1-140/140 Sequence Identity: 72% (101 aa) FIVNKVKLQE---TVVALKESKDDGEGNLEQQMREISILYNLPKNDLIIQYVGHQKHNKQFQIFLEYFDGQTLEKYLNDSQ---KQQDQKPKDLKLQQLQ ||| ||||.| |||| ...... ..|||||||||.|||||.||||||||||.|||||||||||.||||||..|... |.|||..||||||.|| FIVKKVKLKENKDRKVALKQPQEEQNDYSKQQMREISILSNLPKNNLIIQYVGHQKNNKQFQIFLEYFEGQTLEKFINEIYDNKKYQDQNHKDLKLQKLQ ISKQILQAIDYLHEHNIVHGDIKPRNILINSEKKIKIIDF |||||||||||||||||||||||..||||||...|||||| ISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF |
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| Kinase | 26110.AA | Ciliate-E2 | 741-961 | 19 | 8.6e-23 | 75.05 | In-house | 59-365 (365) | Show / Hide |
Range on Protein: 741-961 Range on HMM: 59-365/365 Sequence Identity: 19% (64 aa) NLEQQMREISIL------YNLPK------------NDLIIQYVGHQK--HNKQFQIFLEYFDGQTLEKYLNDSQKQQDQKPK---DLKLQQLQ-ISKQIL ..||...||.|. | | .. ||... . . .. . . .||..|..|..|.....|....... ..... . |.|||| QIEQIKQEIHIMREINCFY---KKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQIL Q---------------AIDYLHEHN-IVHGDIKPRNILINSEKKIKIIDFSESSFMVEE---------------------TLG---------------QT | |. |||. | |.| |||| |||. |||||| | . .. | | | QGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGT PLYAAK----DKF---------KTRQIDYYSLGIMFNIIFGFNKLITSSNCQQEREKYKVENHEKCIPKSASNIDEYQ-------YSQILFYQIQS---- | | | | . ..|..|||... . . |.. |.. . |. . . .| . . || |. PGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKR LLNVQPYLRCT-IKELIYIINL .|...| | | ..... . MLQKDPEKRITGWEQILNHPWF |
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| Kinase | 26110.AA | TKL | 712-867 | 17 | 7.2e-21 | 71.88 | In-house | 1-239 (364) | Show / Hide |
Range on Protein: 712-867
Range on HMM: 1-239/364
Sequence Identity: 17% (44 aa)
ISESQFI-VNKVKLQE----------TVVALKESKDDGEGNLEQ-------------------------QMREISI-LYNLPKNDLIIQYVG---HQKH-
| . | | | |.. ..|| | | . . . . . .| | . . . . |.|..| ..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
---------NKQFQIFLEYFDGQTLEKYLNDSQKQQDQKPKDLKLQQ-LQISKQILQAIDYLHEHN--------IVHGDIKPRNILINSEKK--------
.|. | || .| .|. ||. ..| ......| ....||| .| |.| |.|..|||... .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYN
------IKIIDFSESSFMVEET------------------------LGQTPLY
.|| || | || ... . || .
PNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRW
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| Kinase | 26110.AA | CMGC | 706-850 | 19 | 7.3e-20 | 61.1 | In-house | 1-248 (513) | Show / Hide |
Range on Protein: 706-850 Range on HMM: 1-248/513 Sequence Identity: 19% (48 aa) YSDKKLISESQF-IVNKVKLQE----------------TVVALKESKDDGEGNLEQQ------------MREISILYNLP---------------KNDL- | | | | . .| | . .. .||.| | . ... |||.|| .| |.. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IIQYVGHQKHNK-----------------QFQIFLEYFDGQTLEKYLNDSQK-QQDQKPKDLKLQQ-------------LQIS------KQILQAID--Y |.. . .|.. .. . || | ..| .|. . |. .|...|. |. . .. .|||.... | IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMD-HDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY LHEHN--IVHGDIKPRNILINSEKK--------------------IKIIDF .| |. |.| |.|| |||||.... .||.|| CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF |
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| Kinase | 26110.AA | TKL-Unique | 761-851 | 26 | 2.7e-17 | 57.69 | In-house | 58-162 (290) | Show / Hide |
Range on Protein: 761-851 Range on HMM: 58-162/290 Sequence Identity: 26% (28 aa) IIQYVGHQK----HNKQFQIFLEYFDGQTLEKYLNDSQKQQDQKPKDLKL---QQLQISKQILQAIDYLHEHN--IVHGDIKPRNILINSE-----KKIK | .|.| . ..... |..||..| .| ..|... .. .|| |.... ..| |. .||| . | |.|.|..|.|.... .|| IVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIK IIDFS |.||. ICDFG |
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| Kinase | 26110.AA | Ciliate-E2-Unclassified | 723-961 | 21 | 5e-17 | 55.62 | In-house | 34-352 (352) | Show / Hide |
Range on Protein: 723-961
Range on HMM: 34-352/352
Sequence Identity: 21% (68 aa)
KLQETVVALKESKDDGEGNLEQQMREIS-------------ILYNLPKNDLIIQYVGHQKHNKQFQIFLEYFDGQTLEKYLNDSQK---------QQDQK
| |. . ....|| . | ...| ... ||.|.| . .|. .. . . . . | .||..|..|..|.... | .. ..
KIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHP-HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQ
PKDLKLQQLQ------ISKQILQAIDYLHEHN-IVHGDIKPRNILINSEK---KIKIIDFSESS--------------------FMVEETLGQTPLYA--
| . || . . .||||...|||. | |.| |||| |||..... .||||||. |. .. | .|| |
RKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQ
------AKDKFKTRQ----IDYYSLG-IMFNIIFGFNKLITSSNCQQ------------EREKYKVENHEKCIPKSASNI----DEYQYSQILFYQ--IQ
. . . .|..||| |.. ..|| . || | |. .. . ..| | .. .. . . ... | . .|
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQ
SLLNVQPYLRCTIKELIYIINL
..|...| | |..... .
KMLKKNPNKRITFEQILNHPWF
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| Kinase | 26110.AA | CAMK | 813-850 | 40 | 5.7e-17 | 50.53 | In-house | 186-240 (425) | Show / Hide |
Range on Protein: 813-850 Range on HMM: 186-240/425 Sequence Identity: 40% (22 aa) KQILQAIDYLHEHNIVHGDIKPRNILINSEK-----------------KIKIIDF .||..|..|.|.||||| |.|| |||... . .|||||| RQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF |
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| Kinase | 26110.AA | MARK | 813-850 | 57 | 1.5e-16 | 50.82 | In-house | 111-150 (262) | Show / Hide |
Range on Protein: 813-850 Range on HMM: 111-150/262 Sequence Identity: 57% (23 aa) KQILQAIDYLHEHNIVHGDIKPRNILINSEK--KIKIIDF .||. |. |.|..|||| |||| |||| ... .|||||| RQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDF |
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| Kinase | 26110.AA | STE | 741-850 | 26 | 5e-16 | 53.18 | In-house | 71-191 (359) | Show / Hide |
Range on Protein: 741-850 Range on HMM: 71-191/359 Sequence Identity: 26% (34 aa) NLEQQMREISILYNLPK-NDLIIQYVGHQKHN-------KQFQIFLEYFDGQTLEKYLNDSQKQQDQKP------KDLKLQQL-QISKQILQA-IDYLHE ...| ..||.|. .. . . |..| |. .. . |..|| || .|.. .. . ... . . .. .|. | .|||.. .|||. EMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS HNIVHGDIKPRNILINSEKKIKIIDF |.|.| |||| |||. .|..|| HHIIHRDIKPANILL-----VKLCDF |
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| Kinase | 26110.AA | CDK4 | 810-850 | 43 | 1.2e-15 | 49.96 | In-house | 114-154 (290) | Show / Hide |
Range on Protein: 810-850 Range on HMM: 114-154/290 Sequence Identity: 43% (18 aa) QISKQILQAIDYLHEHNIVHGDIKPRNILINSEKKIKIIDF ....|.| ..|.|| | |.| | || |||..|....|. || HMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADF |
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| Kinase | 26110.AA | S_TKc | 706-959 | 21 | 4.7e-15 | 43.79 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 706-959 Range on HMM: 1-231/231 Sequence Identity: 21% (59 aa) YSDKKLISESQF-IVNKVKLQE--TVVALKESKDDGEGNLEQQMREISILYNLPKNDLIIQYVGHQKHNKQFQIFLEYFDG--QTLEKYLNDSQKQQDQK | ..| . | | |.. . .||.|. | |. .|||.|| . . . |... .. . . . ...|| || .| .|. . ... .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF PKDLKLQQLQISKQILQAIDYLHEHNIVHGDIKPRNILINSEKKIKIIDFSESSFMVEETLGQTPLYA----AKDKFKTRQIDYYSLGIMFNIIFG---- | . . . .||..|..|.|.|.|.| |.|| |||... |||.|| . .. |. || | .. .. .| .|.|... . . PFPE--HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPP FNKLITSSNCQQEREKYKVENHEKCIPKSASNIDEYQYSQILFYQIQSLLNVQPYLRCTIKELIY---------II | |. . .|. |. . |. .|.. | | |. |. . FP---------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 26110.AA | Pkinase | 719-850 | 25 | 1.3e-14 | 52.76 | Pfam | 15-156 (293) | Show / Hide |
Range on Protein: 719-850 Range on HMM: 15-156/293 Sequence Identity: 25% (38 aa) VNKVKLQETV--VALKESKDDGEGNLEQQM----REISILYNLPKNDLIIQYVGHQKHNKQFQIFLEYFDGQ----TLEKYLNDSQKQQDQKPKDL--KL | | . . | ||.|. | ..| ..| .||.|. .| . . |... . .. . .|| .| | |. .. . . VYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST------WRHGCFYFSE QQLQ-ISKQILQAIDYLHEHNIVHGDIKPRNILINSEKKI----KIIDF .... . .|||....|.|...|.| |.|| ||||... | ||.|| WECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF |
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| Kinase | 26110.AA | TyrKc | 706-959 | 15 | 4e-09 | -75.09 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 706-959
Range on HMM: 1-280/280
Sequence Identity: 15% (50 aa)
YSDKKLISESQF-IVNKVKLQETVVALKESKDDGEGNLEQQMREISILYNL-PKNDLIIQYVGHQKHN-------KQFQIFLEYFDGQTLEKYLNDSQKQ
. .| . | .| .| | .. . || | |.| .| |||..|. .| .... |.. .| . .. | .|| .. | .|| .....
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK
QDQKPKDLKLQQLQISKQILQAIDYLHEHNIVHGDIKPRNILINSEKKIKIIDF-------SE-------SSFMV-----EE------------------
. |... || . .|||..|..| |. ||.|..... .|| || .. . .. .
------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF
-----------------TLGQTPLYA------AKDKFKTRQIDYYSLGIMFN---IIFGFNKLITSSNCQQEREKYKVENHEKCIPKSASNIDEYQYSQI
|.||.| . . . . | . .. | . . ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------F----VCCPDE
LFYQIQSLLNVQPYLRCTIKELIYII
.. ... . .| |.| .|.. ..
MYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 26110.AA | Pkinase_Tyr | 725-850 | 26 | 2e-06 | 22.06 | Pfam | 27-155 (270) | Show / Hide |
Range on Protein: 725-850 Range on HMM: 27-155/270 Sequence Identity: 26% (35 aa) QETVVALKESKDDGEGN---LEQQMREISILYNLPKNDLIIQYVGHQK-HNKQ--FQIFLEYFDGQTLEKYLNDSQKQQDQKPKDLKLQQLQISKQILQA ... || | |.. .| |||..|. .|.... |....| . .. | .|| . | .|| . ..|.. . ||.. || .. TKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---EDKQPLTMKDLLQMCWQIAKG IDYLHEHNIVHGDIKPRNILINSEKKIKIIDF .||...|..| |. ||.|.......|| || MEYLESKNCIHRDLAARNCLVTENNVVKICDF |
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