Gene 9189 (Tetrahymena)
9189
Group:
Other
Family:
Ciliate-C3
Sequence
Protein domains of 9189.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 9189.AA | Ciliate-C3 | 676-813 | 85 | 4.7e-95 | 322.11 | In-house | 1-140 (140) | Show / Hide |
Range on Protein: 676-813 Range on HMM: 1-140/140 Sequence Identity: 85% (119 aa) FIVKKVKLKENKDSIVALKQSQDDGKDCLKQQMREISILSNLPKNNLIIQYVGHQKNNKQFEIFLEYFNGQTLQSFINELN--KKYQDQNHKDLKLQKLQ |||||||||||||..|||||.|....|..||||||||||||||||||||||||||||||||.||||||.||||..||||.. ||||||||||||||||| FIVKKVKLKENKDRKVALKQPQEEQNDYSKQQMREISILSNLPKNNLIIQYVGHQKNNKQFQIFLEYFEGQTLEKFINEIYDNKKYQDQNHKDLKLQKLQ ISKQILQAIEYLHEYNIVHGDIKFTNILINSKGEIKIIDF |||||||||.||||.|||||||||.|||||||.||||||| ISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF |
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| Kinase | 9189.AA | Ciliate-E2 | 665-850 | 21 | 1.8e-22 | 73.96 | In-house | 1-286 (365) | Show / Hide |
Range on Protein: 665-850 Range on HMM: 1-286/365 Sequence Identity: 21% (63 aa) YEELEEISRSQF-IVKKVKLKENKD----------------------SIVALKQSQDDGKDCLKQ---QMREIS----------ILSNLPKNNLIIQYVG |. .. | . .| .|.|.| .... .|.|.|. . ... .|| .|||| ||..| ... ||... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQL-NHPNIIKMYE HQK--NNKQFEIFLEYFNGQTLQSFINELNKKY-----QDQNHKDLKLQKLQISKQILQ---------------AIEYLHEYN-IVHGDIKFTNILINSK . . ... . . .||..|..|...|.. .|| . . .. . ..|.||||| |.||||. | |.| ||| |||. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--- GEIKIIDFSESSFMIEE----------------------------------------TLGYTRG----YDA-----KDNVKTRYVDYYSLGILL |||||| | . .. |.|| . | . . .|..|||..| --IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL |
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| Kinase | 9189.AA | Ciliate-E2-Unclassified | 665-850 | 21 | 3e-19 | 63.46 | In-house | 1-260 (352) | Show / Hide |
Range on Protein: 665-850
Range on HMM: 1-260/352
Sequence Identity: 21% (57 aa)
YEELEEISRSQF-IVKKVKLKENKDSIVALKQSQDDGKDCLKQQ------MREISILSNLP------------------KNNLIIQYVGHQKNNKQFEIF
|. .. | . .| .|.|.. |..| . |.|. . .. ||. |.|. .. |. .. .|. .. . .. . . |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV
LEYFNGQTLQSFINELNK-------KYQDQNH-KDLKLQKLQ------ISKQILQAIEYLHEYN-IVHGDIKFTNILINSKG---EIKIIDFSESS----
.||..|..|. .|.. .| ....... | . |. . . .||||..||||. | |.| ||| |||....| .||||||. |.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
----------------FMIEETLGYTRGYD--------AKDNVKTRY----VDYYSLGILL
... | | .| . . .|..|||..|
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
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| Kinase | 9189.AA | CMGC | 665-813 | 18 | 1.4e-16 | 50.17 | In-house | 1-248 (513) | Show / Hide |
Range on Protein: 665-813 Range on HMM: 1-248/513 Sequence Identity: 18% (46 aa) YEELEEISRSQF-IVKKVKLKENK-------------DSIVALKQSQDDGKDCLKQQ------------MREISILSNLP-----------------KNN || .. | . . .| | . |... . |||.| . . .. |||.|| .| .|| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN LI-IQYVGHQKN---------------NKQFEIFLEYFNGQTLQSFINELNKKYQDQNHKDLKLQK-------------LQIS------KQILQAIE--Y .. .... . || .... . || ...| .| . ...||... . |. . .. .|||.... | IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYM-DHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY LHEYN--IVHGDIKFTNILINSK--------------------GEIKIIDF .| . |.| |.| |||||.. |..||.|| CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF |
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| Kinase | 9189.AA | MARK | 776-813 | 57 | 3.5e-15 | 46.26 | In-house | 111-150 (262) | Show / Hide |
Range on Protein: 776-813 Range on HMM: 111-150/262 Sequence Identity: 57% (23 aa) KQILQAIEYLHEYNIVHGDIKFTNILINSKG--EIKIIDF .||. |..|.|. |||| ||| |||| ..| |||||| RQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDF |
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| Kinase | 9189.AA | Ciliate-E8 | 777-816 | 50 | 3.7e-15 | 43.79 | In-house | 97-138 (138) | Show / Hide |
Range on Protein: 777-816 Range on HMM: 97-138/138 Sequence Identity: 50% (21 aa) QILQAIEYLHEYNIVHGDIKFTNILINS--KGEIKIIDFSES ||. |. ||| ||.| |.| |||. |||||| | QIMDAFCYLHNNNIIHCDFKLNNILVQRNDDTKIKIIDFGFS |
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| Kinase | 9189.AA | Pkinase | 678-813 | 26 | 4.1e-15 | 54.53 | Pfam | 15-156 (293) | Show / Hide |
Range on Protein: 678-813
Range on HMM: 15-156/293
Sequence Identity: 26% (40 aa)
VKKVKLKENKDSIVALKQSQDDGKDCLKQQM----REISILSNLPKNNLIIQYVGHQKNNKQFEIFLEYFNGQ----TLQSFIN-ELNKKYQDQNHKDLK
|.| . | . . |||.|. ..... |.| .||.|. .| . |... . ... . .|| .| | ..| . .... ...|
VYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECK
LQKLQISKQILQAIEYLHEYNIVHGDIKFTNILINSKGEI----KIIDF
. .|||...||.|. .|.| |.| ||||...|.| ||.||
F----YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF
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| Kinase | 9189.AA | MKC | 774-813 | 57 | 5.8e-15 | 52.58 | In-house | 107-146 (260) | Show / Hide |
Range on Protein: 774-813 Range on HMM: 107-146/260 Sequence Identity: 57% (23 aa) ISKQILQAIEYLHEYNIVHGDIKFTNILINSKGEIKIIDF . | .||...|||| |||| |.| || .|..||||.||| VCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDF |
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| Kinase | 9189.AA | Ciliate-E9 | 774-813 | 43 | 1.1e-14 | 42.96 | In-house | 116-156 (298) | Show / Hide |
Range on Protein: 774-813 Range on HMM: 116-156/298 Sequence Identity: 43% (18 aa) ISKQILQAIEYLHEYN-IVHGDIKFTNILINSKGEIKIIDF . ||.. .|||.| | | | |.| |.||. . ..||.|| YFKQLIDSIEYMHQYQNICHRDLKPENMLIDKNYNMKICDF |
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| Kinase | 9189.AA | CAMKL | 776-813 | 52 | 3.3e-14 | 41.58 | In-house | 134-173 (297) | Show / Hide |
Range on Protein: 776-813 Range on HMM: 134-173/297 Sequence Identity: 52% (21 aa) KQILQAIEYLHEYNIVHGDIKFTNILINSKG--EIKIIDF .||. |..|.|. .||| ||| |||. ..| |||||| RQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDF |
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| Kinase | 9189.AA | SLK | 665-813 | 24 | 6.7e-14 | 43.17 | In-house | 1-141 (259) | Show / Hide |
Range on Protein: 665-813
Range on HMM: 1-141/259
Sequence Identity: 24% (37 aa)
YEELEEISRSQF-IVKKVKLKENKDSIVALKQSQDDGKDCLKQQMREISILSNLPKNNLIIQYVGHQKNNKQFEIFLEYFNGQTLQSFINELNKKYQDQN
.| . |. | |.| . | ... . | | . . .. |. | || |||.. |.. | . .|| ...|. .| . . . ||.. ...
WEIIGELGDGAFGKVYKAQHK-EQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNK-LWMMIEFCDGGAVDNIMVELEHPLTED-
HKDLKLQKLQISKQILQAIEYLHEYNIVHGDIKFTNILINSKGEIKIIDF
| ..|....|...||. ...| |.| |||. |.... ||
------QIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADF
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| Kinase | 9189.AA | S_TKc | 665-925 | 20 | 1.4e-13 | 22.23 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 665-925 Range on HMM: 1-231/231 Sequence Identity: 20% (58 aa) YEELEEISRSQF-IVKKVKLKENKDSIVALKQSQDDGKDCLKQQMREISILSNLPKNNLIIQYVGHQKNNKQFEIFLEYFNG--QTLQSFINELNKKYQD || |..| . | |.|.. |. . |||.|. .. .|||.||.. . |... .. . . . ...|| .| .| ..| . ... . YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --QNHKDLKLQKLQISKQILQAIEYLHEYNIVHGDIKFTNILINSKGEIKIIDFSESSFMIEETLGYTRGY---DAKDNVKTRYVDYYSLGILLIRIFY- . . . . .||..|.||.|. .|.| |.| |||... .|||.|| . .. |. |. | .. .| .|.|..|. .. FPFPE-HARF----YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCG KSDFEIVCNCQEEGKICNMENHEGFIHEKTCNIDEQRINQYSQNFFDQIKSLLNDQPYLRCTLKELIY---------II . |. |.. . .. |. . | |. .|. | | | |. . YPPFP-----QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 9189.AA | TyrKc | 665-925 | 19 | 7.6e-08 | -95.83 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 665-925 Range on HMM: 1-280/280 Sequence Identity: 19% (58 aa) YEELEEISRSQF-IVKKVKLKENKDSIVALKQSQDDGKDCLKQQMREISILSNL-PKNNLIIQYVGHQKNN-------KQFEIFLEYFNGQTLQSFINEL . .... . .| .| | ..| || | ..| .. |||..|...| ... |.. .| .. | .|| . |.... . ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH NKKYQDQNHKDLKLQKLQISKQILQAIEYLHEYNIVHGDIKFTNILINSKGEIKIIDFSESSFMIEETLGY------TRGYDAKD--NVKT-RYVDYYSL .| ..|... || . ||||. |..| |. |.|..... .|| || . . . . |..| . || . ... RPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG----LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP GILLIRIFY-KSD--------FEIVCNCQEEGKI-CN--MENHEGFIHEKTCNIDEQRIN-------QYSQNFFDQIKSLLNDQPYLRCTLKELIYII . ..| ||| .|| ..|. |.| | . . |. . .| | .. .. .|. . .| |.| .|.. .. ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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