Gene 11769 (Tetrahymena)
11769
Group:
Other
Family:
Ciliate-C4
Sequence
Protein domains of 11769.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 11769.AA | Ciliate-C4 | 395-744 | 44 | 1.2e-231 | 749.78 | In-house | 1-361 (361) | Show / Hide |
Range on Protein: 395-744 Range on HMM: 1-361/361 Sequence Identity: 44% (162 aa) YIKRKCLGKSGFSKIFLCERKSDDRQFICKEVDFSKDEKAKELYLNEIEFYSCFMRNSQVKDYFQKYPGFKYIPQMDYNEILINYMTDVEYGFLITEFLQ |||||||||.|||...||..|....||.||................||.|||..|||.|||.|.|.|.|||..|||.|||||||||.|......|.|... YIKRKCLGKGGFSLVWLCKQKKTQQQFACKQICNQNNQDSHQRHMKEIWFYSFYMRNGQVKEYYQMYQGFKNLPQMMYNEILINYMKDQKDTWIIYELCG KPLRKSIFDVKKETIAG-EEMYQINLKPLYNHLVEEPDN--FKRFIKDIAEYLSFLQQNKWSHGDLRLDNIVISST-QIAGSEFLDYFKVIDYCSSFRTN |.||||....|.|.... |..|.||.|.||.||.....| .|.||..|...|..|.||||.|.|....||..... ...||......|.||..|.|..| KSLRKSLYEIKGEDYCQNERVYKINFKKLYYHLFQDKNNNLCKKFIQHICHALWHLHQNKWVHCDIKPENILVKYKSDFGGSNNIQQVKLIDFGSCFQFN KFKGLQSHITPEYMPPEFLKHLIADKFEDEQLQQDVQYDVFQYAVDPEAPSSLDIWSLGCLILELVLAVPLWVTQRCRVKQK---NFIMRGLFATKERKI ..|..||..||||||||.|...|....|||||||..|.|.|||....|.|.|.||||.||...|.....|.|....|||..| |||..|.|..|.... NKKHIQSMATPEYMPPEMLNFIIQEQNEDEQLQQNHQHDMFQYLQNYECPWSIDIWSMGCVMMEIITGIPHWMSYKCRVHHKQVKNFIKHGIFCHKQQCF EQIYTKQKKFLKQYLQIMKSLKIG----NLDKQIKLILDGCLKVNPRERITPEQILDILSK |.|..|||||.||..|.||..... ..|.|.|......||.||||||.|.|..... ENIIQKQKKFCKQIDQYMKEHNYQFCCQVIDQQLKDLIKKMLKFNPRERISPKQCCQHPWI |
|||||||||
| Kinase | 11769.AA | S_TKc | 395-747 | 13 | 1.9e-11 | -9.03 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 395-747
Range on HMM: 1-231/231
Sequence Identity: 13% (48 aa)
YIKRKCLGKSGFSKIFLCERKSDDRQFICKEVDFSKDEKAKELYLNEIEFYSCFMRNSQVKDYFQKYPGFKYIPQMDYNEILINYMTDVEYGFLITEFLQ
| . . .|| .|.| ..| |...|.. .|... .. ..|| | . . .. . .. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQ
KPLRKSIFDVKKETIAGEEMYQINLKPLYNHLVE----------EPDNFKRFIKDIAEYLSFLQQNKWSHGDLRLDNIVISSTQIAGSEFLDYFKVIDYC
.. |. .| |. .... . ..... |.. | .. ... | || .|| ... |..|
D----------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFG
SSFRTNKFKGLQSHITPEYMPPEFLKHLIADKFEDEQLQQDVQYDVFQYAVDPEAPS-SLDIWSLGCLILELVLAVPLWVTQRCRVKQKNFIMRGLFATK
.. . ||.||.|| | . |.||.||.. |.. |.. | . ... .
LARQL-----TTFCGTPWYMAPEVL----------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG---
ERKIEQIYTKQKKFLKQYLQIMKSLKIGNLDKQIKLILDGCLKVNPRERITPEQILD----ILSKKDL
... | ....||...|..|.| ..| | . .
------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | 11769.AA | Ciliate-E2 | 644-740 | 21 | 1.8e-08 | 25.14 | In-house | 278-361 (365) | Show / Hide |
Range on Protein: 644-740 Range on HMM: 278-361/365 Sequence Identity: 21% (23 aa) DIWSLGCLILELVLAVPLWVTQRCRVKQKNFIMRGLFATKERKIEQ--IYTKQKKFLKQYLQIMKSLKIG-----NLDKQIKLILDG----CLKVNPRER ||||||... |.. | . ...|.| | .... | .| .. . .. ..... | .. .|...| .| DIWSLGVILYEMLFGKPPF---------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKR IT-PEQILD || .||||. ITGWEQILN |
|||||||||
| Kinase | 11769.AA | Ciliate-E2-Unclassified | 554-739 | 18 | 2.5e-08 | 24.99 | In-house | 167-347 (352) | Show / Hide |
Range on Protein: 554-739
Range on HMM: 167-347/352
Sequence Identity: 18% (43 aa)
HGDLRLDNIVISSTQIAGSEFLDYFKVIDYCSS---------FRTN--------KFKGLQSHI-TPEYM----PPEFLKHLIAD--KFEDEQLQQDVQYD
| |. ..||.... . | |.||. .| || |.. ... . ||.|| .|| |. | |.
HRDIKPENILFDNNGK-----NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------------
VFQYAVDPEAPSSLDIWSLGCLILELVLAVPLWVTQRCRVK----------------QKNFIMRGLFATKERKI----EQIYTKQKKFLKQYLQIMKSLK
. ||||||... |.. . .... . ... |. . . .. . .. ..| |..
-----------YKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN----------
IGNLDKQIKLILDGCLKVNPRERITPEQIL
.| .||.|| .|||.||||
---------DLLQKMLKKNPNKRITFEQIL
|
|||||||||
| Kinase | 11769.AA | Pkinase | 600-742 | 15 | 5.5e-08 | 29.31 | Pfam | 174-293 (293) | Show / Hide |
Range on Protein: 600-742 Range on HMM: 174-293/293 Sequence Identity: 15% (24 aa) TPEYMPPEFLKHLIADKFEDEQLQQDVQYDVFQYAVDPEAPSSLDIWSLGCLILELVLAVPLWVTQ----RCRVKQKNFIMRGLFATKERKI-------- ||.||.|| .. ... ... |.||.||.. |... |.. . . . ... . ... ... TPWYMAPEVIR------------------------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYF EQIYTKQKKFLKQYLQIMKSLKIGNLDKQIKLILDGCLKVNPRERITPEQILDI--L . ... . . . ... |... | ....||...| .|.|.|||| . F-FRH-W-H-------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | 11769.AA | CMGC | 641-740 | 13 | 2.9e-07 | 18.96 | In-house | 314-509 (513) | Show / Hide |
Range on Protein: 641-740
Range on HMM: 314-509/513
Sequence Identity: 13% (26 aa)
SSLDIWSLGCLILELVLA--------VPLWVTQRCR----------VKQKNFIMR--GLF-------------ATKERKIEQIYTKQ-------------
.. |.||.|| . |... ||. .. .. . | . |.. | . ...|... .. ..
TPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQT
-----KKFLKQYLQIMKSLKIGN---------------------------------------------LDKQIKLILDGCLKVNPRERITPEQILD
..| ..|.|. .... . .|.| |...|. .| .|||.||.|.
MTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQ
|
|||||||||
| Kinase | 11769.AA | Ciliate-B1 | 712-743 | 39 | 5e-07 | 20.76 | In-house | 258-290 (290) | Show / Hide |
Range on Protein: 712-743 Range on HMM: 258-290/290 Sequence Identity: 39% (13 aa) NLDKQIKL-ILDGCLKVNPRERITPEQILDILS |....|. |. ||...| ||| ||.|.|. NIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM |
|||||||||
| Kinase | 11769.AA | Ciliate-E2 | 395-443 | 21 | 9.8e-07 | 19.12 | In-house | 1-56 (365) | Show / Hide |
Range on Protein: 395-443 Range on HMM: 1-56/365 Sequence Identity: 21% (12 aa) YIKRKCLGKSGFSKIFLCERKSDDRQFICKEVDFSK--------DEKAKELYLNEIE |.. |..|. .|.....|.......||. | | | |.|. ... .. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMK |
|||||||||
| Kinase | 11769.AA | ULK | 644-741 | 17 | 2e-06 | 18.6 | In-house | 234-321 (324) | Show / Hide |
Range on Protein: 644-741 Range on HMM: 234-321/324 Sequence Identity: 17% (18 aa) DIWSLGCLILELVLAVPLWVTQRCRVKQ----KNFIMRGLFATKERKIEQIYTKQKKFLKQYLQIMKSL--KIGNLDKQIKLILDGCLKVNPRERITPEQ |||||||.. |.. . .... . . | .. . . | ... .. .| . . |. .. ...| .. ..|......||. |. DIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNG-K-E------------Q-QIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEE ILDI |... IFNH |
|||||||||
| Kinase | 11769.AA | Ciliate-E2-Unclassified | 395-424 | 28 | 8e-06 | 16.17 | In-house | 1-34 (352) | Show / Hide |
Range on Protein: 395-424 Range on HMM: 1-34/352 Sequence Identity: 28% (10 aa) YIKRKCLGKSGFSKIFLCERKSDDRQF-----ICK |.. |..|. ||.|...|..|... |. ..| YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKK |
|||||||||
| Kinase | 11769.AA | GAK | 723-742 | 35 | 1.4e-05 | 14.47 | In-house | 258-277 (277) | Show / Hide |
Range on Protein: 723-742 Range on HMM: 258-277/277 Sequence Identity: 35% (7 aa) GCLKVNPRERITPEQILDIL .||.|||.||.. ... . ACLQVNPDERLDIAMVVEYM |
|||||||||
| Kinase | 11769.AA | NEK | 395-442 | 27 | 3.7e-05 | 14.57 | In-house | 1-55 (286) | Show / Hide |
Range on Protein: 395-442 Range on HMM: 1-55/286 Sequence Identity: 27% (15 aa) YIKRKCLGKSGFSKIFLCERKSDDRQ-----FICKEVDFSK-DEKAKELYL-NEI | . | .|. |.| ....|||| .. .. |...... .|| |. . ||. YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEV |
|||||||||
| Kinase | 11769.AA | AGC | 395-421 | 21 | 4.9e-05 | 7.38 | In-house | 1-33 (395) | Show / Hide |
Range on Protein: 395-421 Range on HMM: 1-33/395 Sequence Identity: 21% (7 aa) YIKRKCLGKSGFSKIFLCERK------SDDRQF . |..|| .|.| .|...| . .... FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYY |
|||||||||
| Kinase | 11769.AA | ULK | 697-741 | 17 | 9.2e-05 | 12.65 | In-house | 260-326 (329) | Show / Hide |
Range on Protein: 697-741 Range on HMM: 260-326/329 Sequence Identity: 17% (12 aa) FLKQYLQIMKSL----------------------KIGNLDKQIKLILDGCLKVNPRERITPEQILDI | .|||||...| .. .. ...| .. ..|......||. |..... FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNH |
|||||||||
| Kinase | 11769.AA | Ciliate-E2 | 544-610 | 18 | 0.000196 | 11.11 | In-house | 173-260 (365) | Show / Hide |
Range on Protein: 544-610 Range on HMM: 173-260/365 Sequence Identity: 18% (19 aa) LSFLQQNK-WSHGDLRLDNIVISSTQIAGSEFLDYFKVIDYCSS-----FRTNKFKGLQSHI-----------------------------TPEYMPPEF | .| ... | |. ..||.. |.|| | .. |... .| . ||.||.|| LEYLHSKNNIIHRDIKPENILF-------------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI LK |. LN |
|||||||||
| Kinase | 11769.AA | ULK | 395-443 | 25 | 0.006741 | 6.19 | In-house | 1-62 (324) | Show / Hide |
Range on Protein: 395-443 Range on HMM: 1-62/324 Sequence Identity: 25% (16 aa) YIKRKCLGKSGFS-KIFLCE-RKSD--DRQFICKEVD---FSKDEKA------KELYLNEIE |....|||| | | . . |.. . .. || .| ..|... ..| |||. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQ |
|||||||||
| Kinase | 11769.AA | NEK | 644-656 | 61 | 0.007737 | 6.29 | In-house | 206-218 (286) | Show / Hide |
Range on Protein: 644-656 Range on HMM: 206-218/286 Sequence Identity: 61% (8 aa) DIWSLGCLILELV |||||||.. |.. DIWSLGCVLYEMC |
|||||||||
| Kinase | 11769.AA | ULK | 395-443 | 24 | 0.010113 | 5.43 | In-house | 1-62 (329) | Show / Hide |
Range on Protein: 395-443 Range on HMM: 1-62/329 Sequence Identity: 24% (15 aa) YIKRKCLGKSGFSKIFLCE-RKSD---DRQFICKEVD---FSKDEKA------KELYLNEIE |....|||| | | . . |.. . ...|| .| ...... ..| |||. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIK |
|||||||||
| Kinase | 11769.AA | AGC | 600-652 | 27 | 0.012096 | 1.06 | In-house | 270-295 (395) | Show / Hide |
Range on Protein: 600-652 Range on HMM: 270-295/395 Sequence Identity: 27% (15 aa) TPEYMPPEFLKHLIADKFEDEQLQQDVQYDVFQYAVDPEAPSSLDIWS--LGCLI |||||.|| | . |.|| ||||. TPEYMAPEIL-----------------------------YGKACDWWSFGLGCLM |
|||||||||
| Kinase | 11769.AA | Ciliate-B1 | 644-655 | 58 | 0.020023 | 4.44 | In-house | 211-222 (290) | Show / Hide |
Range on Protein: 644-655 Range on HMM: 211-222/290 Sequence Identity: 58% (7 aa) DIWSLGCLILEL ||||.||.. |. DIWSFGCIMYEI |
|||||||||
| Kinase | 11769.AA | Ciliate-B1 | 395-413 | 21 | 0.088497 | 2.15 | In-house | 1-19 (290) | Show / Hide |
Range on Protein: 395-413 Range on HMM: 1-19/290 Sequence Identity: 21% (4 aa) YIKRKCLGKSGFSKIFLCE | . . .|. ..|..|... YQQNNVIGQGAISQVFYGQ |
|||||||||
| Kinase | 11769.AA | Pkinase | 395-439 | 15 | 1.109972 | 3.49 | Pfam | 1-53 (293) | Show / Hide |
Range on Protein: 395-439 Range on HMM: 1-53/293 Sequence Identity: 15% (8 aa) YIKRKCLGKSGFSKIFLCERKSDDRQFICKEVDFSKDEKAK--------ELYL | . ...|. .|.. ..| .|.. ... .|... ..... | |... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQI |
|||||||||