Gene 3472 (Tetrahymena)
3472
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 3472.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 3472.AA | GSK | 218-261 | 34 | 4.8e-12 | 32.47 | In-house | 201-243 (328) | Show / Hide |
Range on Protein: 218-261 Range on HMM: 201-243/328 Sequence Identity: 34% (15 aa) DIWSLGCIFCELFITEKPLFESENFNQQAIKYFEILGIPDKSEI |.||.||.. |.... .||| .. . |.. ....|| |.| .| DVWSCGCVMAEMLKG-QPLFPGDSSVDQLVEIIKMLGTPTKEQI |
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| Kinase | 3472.AA | CMGC | 215-327 | 14 | 6.5e-12 | 34.49 | In-house | 314-513 (513) | Show / Hide |
Range on Protein: 215-327 Range on HMM: 314-513/513 Sequence Identity: 14% (28 aa) KKADIWSLGCIFCELFIT-------EKPLFESENF-----------NQQAIKYFEILGIPD---------------KSEIIYIEE--------------- .. |.||.|||| |.. |||| .. | | |..|| |. . |.... . TPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQT ---DIQKAIDQAI-----LTKGELYNISYINTVILN-------------------------------CRTEYEKYVILNTLQFDPQIRTSLKSLLEESQI .. . ..| . . ... . . | | .. . . ||.||. | . . |. . MTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |
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| Kinase | 3472.AA | p38 | 215-258 | 38 | 1.2e-09 | 28.88 | In-house | 183-225 (289) | Show / Hide |
Range on Protein: 215-258 Range on HMM: 183-225/289 Sequence Identity: 38% (17 aa) KKADIWSLGCIFCELFITEKPLFESENFNQQAIKYFEILGIPDK ...||||.||| || ||...|| .....| . ...| ||. QTVDIWSVGCIMAEL-ITGRTLFPGDDHIDQLQRIMKVCGTPDE |
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| Kinase | 3472.AA | CDK5 | 218-256 | 41 | 1.8e-09 | 25.58 | In-house | 181-219 (287) | Show / Hide |
Range on Protein: 218-256 Range on HMM: 181-219/287 Sequence Identity: 41% (16 aa) DIWSLGCIFCELFITEKPLFESENFNQQAIKYFEILGIP |.|| |||| |. . .||| . . | . |.|.| | DMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTP |
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| Kinase | 3472.AA | CDC2 | 218-237 | 59 | 4.2e-08 | 20.45 | In-house | 188-209 (301) | Show / Hide |
Range on Protein: 218-237 Range on HMM: 188-209/301 Sequence Identity: 59% (13 aa) DIWSLGCIFCEL--FITEKPLF |.||.|||| |. .| |||| DMWSIGCIFAEMFMDVTKKPLF |
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| Kinase | 3472.AA | DYRK2 | 191-259 | 37 | 5.7e-08 | 21.66 | In-house | 168-224 (318) | Show / Hide |
Range on Protein: 191-259 Range on HMM: 168-224/318 Sequence Identity: 37% (26 aa) YTAPEIFFQYNYGKKLINKLYLEAKKADIWSLGCIFCELFITEKPLFESENFNQQAIKYFEILGIPDKS | |||.. . ||. |.||.||| ||.. .||| || | | |.||.|.|. YRAPEVILGGKYGMAI-----------DMWSFGCIMAELYTG-YPLFPGENENDQFACMMEVLGMPPKK |
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| Kinase | 3472.AA | CDK | 218-237 | 63 | 1.6e-07 | 19.95 | In-house | 204-225 (284) | Show / Hide |
Range on Protein: 218-237 Range on HMM: 204-225/284 Sequence Identity: 63% (14 aa) DIWSLGCIFCELFI--TEKPLF |.||.|||| |.| | |||| DMWSVGCIFAEMFTDVTRKPLF |
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| Kinase | 3472.AA | CK2 | 218-257 | 35 | 1.7e-07 | 17.6 | In-house | 178-217 (288) | Show / Hide |
Range on Protein: 218-257 Range on HMM: 178-217/288 Sequence Identity: 35% (14 aa) DIWSLGCIFCELFITEKPLFESENFNQQAIKYFEILGIPD |.|||||.| . . |.|. .. . | .| .|| | DMWSLGCMFASMIFKKEPFFHGHDNYDQLVKIVKVLGTED |
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| Kinase | 3472.AA | MAPK | 215-267 | 37 | 2.5e-07 | 21.17 | In-house | 213-266 (328) | Show / Hide |
Range on Protein: 215-267 Range on HMM: 213-266/328 Sequence Identity: 37% (20 aa) KKADIWSLGCIFCELFITEKPLFESENFNQQAIKYFEILGIPDKSEIIYIE-ED |. |.||.|||| |. |||| .. | . .|.|| |.. | .|. . KAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSE |
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| Kinase | 3472.AA | Ciliate-E2-Unclassified | 191-245 | 34 | 3.7e-07 | 20.9 | In-house | 232-278 (352) | Show / Hide |
Range on Protein: 191-245 Range on HMM: 232-278/352 Sequence Identity: 34% (19 aa) YTAPEIFFQYNYGKKLINKLYLEAKKADIWSLGCIFCELFITEKPLFESENFNQQ |||||.. . ||... .|.||||||.|. |. . . |...| .|. YTAPEVLQGQNYDHSKA-------YKCDIWSLGVILYEMLFGY-YPFYDNNCEQH |
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| S_TKc | 3472.AA | S_TKc | 38-328 | 16 | 2e-06 | -83.99 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 38-328 Range on HMM: 1-231/231 Sequence Identity: 16% (51 aa) YILHGNIKQ-------TGRKIKITRKEFCIKSDLVVKRFVSLMKCFE---NNIVIADDIFLSLENGDIYLYVVEPYKDD---TQHQDIVRLVDLLHFCKI | .. | . .|..| | ... || ... . ... . ||| |.| . .||.| | | . .. |.. ... YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--EHIRREIQILKKHHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF NRKTKLDIFINLLNCLQFLQDLDVQYIELNPKSIWIQNEQKVYLKPFNIDIEESYHLSAIQQTKAKYTAPEIFFQYNYGKKLINKLYLEAKKADIWSLGC . . .. ... |... .. . . | | | . . . . | . . . . | | |||.. .|.|.||.|| PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPW-YMAPEVL-------------GYGKCKCDWWSCGC IFCELFITEKPLFESENFNQQAIKYFEILGIPDKSEIIYIEEDIQKAIDQAILTKGELYNISYINTVILNCRTEYEKYVILNTLQFDPQIRTSLKSLLE- |. |.. .|.|. | . |...| .. | | . ||.||. | . .|. ILYEMLC-GYPPFP------QMQMMFKKIG------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQD E-----SQIF | . | EWDIKCHPWF |
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| Kinase | 3472.AA | Pkinase | 215-266 | 22 | 0.000563 | 15.14 | Pfam | 191-265 (293) | Show / Hide |
Range on Protein: 215-266 Range on HMM: 191-265/293 Sequence Identity: 22% (17 aa) KKADIWSLGCIFCELFITEKPLFESE----NFNQQAIKYFEILGIPDKSEIIYI---------------------EE .|.|.||.|||. |.. .|.| .. | . | ....|.| | .... . || PKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE |
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