Gene 6536 (Tetrahymena)
6536
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 6536.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 6536.AA | Ciliate-C7 | 85-247 | 38 | 4e-37 | 116.91 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 85-247 Range on HMM: 1-164/164 Sequence Identity: 38% (64 aa) ISLISAGIQSFVVRALNTRNQQRCAIKC--IRTKYKQLSSQEIENQIQQEVECFKQCRNSSNVVKLIHSQQCEEFTYLVFQECQK-SLQHLLADNQNK-F . ...| |. |. | . .. | ||| .|.| ... |.| || |||.. |||. |..||.|.|. ..|.||| ||| .|. .. |||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNI-DQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRL SEIAVVKYSMNVAQGLYDAQVKNCSVLDLKPENILIDQFGNALISKFVLDVQSSLESKVIVGNSPYK .|| .||. .||||| ||| | ||| .|||||. |||... ... |. | . . | NEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVC--DFGLADNLTQKSKYQINQYM |
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| Kinase | 6536.AA | Ciliate-E1 | 88-227 | 20 | 7.9e-18 | 54.94 | In-house | 1-153 (202) | Show / Hide |
Range on Protein: 88-227 Range on HMM: 1-153/202 Sequence Identity: 20% (32 aa) ISAGIQSFVVRALNTRNQQRCAIKCIRTKYKQLSSQEIENQIQQEVECFKQCRNSSNVVKLIHSQQCEE--FTYLVFQECQKSLQHLLA----------- |..| .|.|..| . |... .. | . ........|... . .| .. .....| .. .. .....|..|..||. | IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC -DNQNKFSEIAVVKYSMNVAQGLYDAQVKNCSVLDLKPENILIDQFGNALISKF |||.|.. ... .. .|| . . .| .|.||.||||...|| ....| QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDF |
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| Kinase | 6536.AA | S_TKc | 82-347 | 20 | 3e-15 | 46.72 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 82-347 Range on HMM: 1-231/231 Sequence Identity: 20% (57 aa) YQSISLISAGIQSFVVRALNTRNQQRCAIKCIRTKYKQLSSQEIENQIQQEVECFKQCRNSSNVVKLIHSQQCEEFTYLVFQECQK---SLQHLLADNQN |. . .| | . | .. ... ....|||.|. ..|..|... |. . |.|||. . | .. |.|. | .| ... ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR K-----FSEIAVVKYSMNVAQGLYDAQVKNCSVLDLKPENILIDQFGNALISKFVLDVQSSLESKVIVGNSPYKAPESAELIQMPRDMNASKRES--FSL . |.| . .| ....| .. ||||||||.|. . |. | | | . ..| | ||| .|... |. HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---------GYGKCKCDWWSC GMLIYRMLITGENQFEEKLQKVFSEKKVILENELNEFRFRSLLERLVLDLTKFEPEDRISIKDALC-ILKGIFSQYL | ..| || |. |. .. |.|. . . .. . ...||.|... .|| .. ... GCILYEMLC-GYPPFP----QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 6536.AA | ULK | 82-217 | 17 | 2e-14 | 46.81 | In-house | 1-164 (329) | Show / Hide |
Range on Protein: 82-217 Range on HMM: 1-164/329 Sequence Identity: 17% (29 aa) YQSISLISAGIQSFVVRALNTRN----QQRCAIKCIRTKYKQLSSQE-----IENQIQQEVECFKQCR---NSSN----VVKLIHSQQCEEF--TYLVFQ |. . . | | .. | .. .. .|.| | .... ...| . .....|.. |. .. | .|||.. ... . .|... YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME ECQK-SLQHLLADNQN---------KFSEIAVVKYSMNVAQGLYDAQVKNCSVLDLKPENILID |. |.... |.. ..|| .... . ..|. . . .|. |.||.||||. YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIH |
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| Kinase | 6536.AA | CMGC | 82-218 | 16 | 2.4e-11 | 32.6 | In-house | 1-219 (513) | Show / Hide |
Range on Protein: 82-218 Range on HMM: 1-219/513 Sequence Identity: 16% (37 aa) YQSISLISAGIQSFVVRALNTRNQQR--------------CAIKCIRTKYKQLSSQE-------IENQIQQEVECFKQCR----------------NSSN |. |. | | . |... ..|..|. .||| |. . . . .. |... |. . . | YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VVKLIHSQQCEE-----------------FTYLVFQECQKSLQHLLADNQN--------KFSEIA------------VVKYS------MNVAQGLY--DA .|||. . . .. |||| ....| ... .||. ..|| . ... . .|| IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC QVKN--CSVLDLKPENILIDQ .. |||||||||.. HSHWGNIIHRDLKPENILINH |
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| Kinase | 6536.AA | ULK | 82-216 | 19 | 2.1e-10 | 33.19 | In-house | 1-159 (324) | Show / Hide |
Range on Protein: 82-216 Range on HMM: 1-159/324 Sequence Identity: 19% (31 aa) YQSISLISAGIQS-FVVRALNTRN---QQRCAIKCIRTKYKQLSSQE-----IENQIQQEVECFKQCR--NSSN--VVKLIHSQQCE--EFTYLVFQECQ |. . . | | .. | .. .| |.|.| |. . ...| . .....|.. |. .. | .|||.. ... ..|... |. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN K-SLQHLLADNQN--------KFSEIAVVKYSMNVAQGLYDAQVKNCSVLDLKPENILI |.... |.. ..|| .... . ..|. . . .|. |.||.|||| GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI |
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| Kinase | 6536.AA | CAMK | 87-162 | 11 | 3.1e-09 | 25.16 | In-house | 1-136 (425) | Show / Hide |
Range on Protein: 87-162 Range on HMM: 1-136/425 Sequence Identity: 11% (16 aa) LISAGIQSFVVRALNTRNQ------------QRCAIKCIRTKYKQLS-----------------------SQEIENQIQQEVECFKQCR------NSSNV . | . | .. ..... |..||| | .| . . ... . ....|.|. |... . |. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKLIH---------------SQQC-----EEFTYLVF .||.. . .. ... |.|. IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVM |
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| Kinase | 6536.AA | Ciliate-B2 | 127-227 | 30 | 1.3e-08 | 16.29 | In-house | 44-148 (197) | Show / Hide |
Range on Protein: 127-227 Range on HMM: 44-148/197 Sequence Identity: 30% (32 aa) NQIQQEVECFKQCRNSSNVVKLIHSQQCEE-FTYLVFQECQKSLQHLLA---DNQNKFSEIAVVKYSMNVAQGLYDAQVKNCSVLDLKPENILIDQFGNA ..||.|.. | . ||||.| . | .| |. . |. ||. | | .| . .. . || ..| ||.||.|||. | || EEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNY LISKF . . | VYCDF |
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| Kinase | 6536.AA | STE | 82-197 | 16 | 4.2e-08 | 24.83 | In-house | 1-166 (359) | Show / Hide |
Range on Protein: 82-197 Range on HMM: 1-166/359 Sequence Identity: 16% (27 aa) YQSISLISAGIQSFVVRALNT------RNQQR---------CAIKCIRTKYK------------QLSSQEIENQIQQEVECFKQCRN-SSNVVKLIHSQQ .. |. | | |..|.| .... .||| .. . . . . .|...||..|.. |.|.. . |.|| . . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF CE-------EFTYLVFQECQ-KSLQHLLA------DNQN-------KFSEIAVVKYSMNVAQG-LY | . ... . || .. ...| .|.| . .. . .| || KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLY |
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| Kinase | 6536.AA | Pkinase | 82-218 | 23 | 5.8e-08 | 29.25 | Pfam | 1-143 (293) | Show / Hide |
Range on Protein: 82-218 Range on HMM: 1-143/293 Sequence Identity: 23% (34 aa) YQSISLISAGIQSFVVRALNTRNQQRCAIKCIRTKYKQLSSQEIENQIQQEVECFKQCRNSSNVVKLIHSQQCEEFTYLVFQECQK-----SLQHLLA-D |. .. | .| . | .. . .... |.|.|. . .. |...... .|.. | . |. |.|.|... . . |.|. |.. .| ... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW NQNKF--SEIAVVKYSMNVAQGLYDAQVKNCSVLDLKPENILIDQ ....| || . .| ...||. ... ||||||||||. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDN |
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| Kinase | 6536.AA | C8 | 82-275 | 18 | 8.1e-08 | 23.34 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 82-275 Range on HMM: 1-226/226 Sequence Identity: 18% (42 aa) YQSISLISAGIQSFVVRALNTRNQQRCAIKCIRTKYKQLSSQEI----ENQIQQEVECFKQCRNSSNVVKLIHSQQCEEFTY-----------LVFQE-- .. ..| | . |..| |..... ...| . || ... | ...| .. .. | .. .. .. || .| FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME -CQKSLQHLLADNQNK---FSEIAVVKYSMNVAQGLYDAQVKNCSVLDLKPENILIDQFGNAL---------ISKFVLDVQSSLESKVI--VGNSPYKAP |.. |..| . .|| ||. . . . |. ..|| |.||.|.|. .| . .. .| . .|. .|| . .|. | || LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP ESAELIQMPRDMNASKRESFSLGMLI | . . . . .||.|.. EIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 6536.AA | Aur | 208-221 | 73 | 1.6e-05 | 9.99 | In-house | 126-140 (257) | Show / Hide |
Range on Protein: 208-221 Range on HMM: 126-140/257 Sequence Identity: 73% (11 aa) DLKPENILIDQ-FGN |.||||||.|| || DIKPENILLDQCNGN |
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| Kinase | 6536.AA | TyrKc | 82-339 | 11 | 2.9e-05 | -137.64 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 82-339
Range on HMM: 1-280/280
Sequence Identity: 11% (37 aa)
YQSISLISAGIQSFVVRALNTRNQQRCAIKCIRTKYKQLSSQEIENQIQQEVECFKQC-RNSSNVVKLIHSQQCE-------EFTYLVFQECQK-SLQHL
. . . | |... . . .|.|... . . .| . .. . |.|.|. . | ..|. . . .|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY
LADNQNKFSEIAVVKYSMNVAQG---LYDAQVKNCSVL--DLKPENILIDQFGNALISKFVLDVQSSLE------SKVIV------GN--SPYK--APES
| ....|.. .... .|.| | . . || |.|.. . . || | | . ..... |. |.. |||.
LRKHRPKLCMKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC
AELIQMPRDMNASKRES--------FSLGMLIYRMLITGENQFEE-----KLQKVFSEKKVILENELNEFR--------FRSLLERLVLDLTKFEPEDRI
... .| | ... .. |. .. . . |. . . . .. .. ...||||
I-------------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP
SIKDALCIL
. .. ..
TFSEIHECF
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| Kinase | 6536.AA | Aur | 94-134 | 19 | 0.004282 | 3.45 | In-house | 13-51 (257) | Show / Hide |
Range on Protein: 94-134 Range on HMM: 13-51/257 Sequence Identity: 19% (8 aa) SFVVRALNTRNQQRCAIKCIRTKYKQLSSQEIENQIQQEVE ..| | . ....|.|... .|. ....| |...|.. GNVYLARHKKTHFIFALKVMF--KEQIKKYCMEHQLRREIK |
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| Kinase | 6536.AA | CAMK | 207-217 | 81 | 0.039015 | 1.87 | In-house | 203-213 (425) | Show / Hide |
Range on Protein: 207-217 Range on HMM: 203-213/425 Sequence Identity: 81% (9 aa) LDLKPENILID .||||||||.| RDLKPENILLD |
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