Gene 9300 (Tetrahymena)
9300
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 9300.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 9300.AA | CMGC | 177-283 | 16 | 1.3e-13 | 40.17 | In-house | 291-506 (513) | Show / Hide |
Range on Protein: 177-283 Range on HMM: 291-506/513 Sequence Identity: 16% (35 aa) YRAPERIIGYD--------VENMKSEDMFQLGCIILELLAR--------KPVLESEDE-----------TNQMLKYSLFLGRP----------------Q ||||| ..|. . .. || .|||. |.. . || ..| .|. | || | . YRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHE EIIYRNIYHQ-------------------------------LPDTSPVDIDKYLSN-----------------------------------CDQKLVNLI |... | . .| | .. . . ||.....|. EEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLL PQLLVYDPEKRATIQQ ..|.|||.|| |..| KKMLQYDPDKRITAEQ |
|||||||||
| S_TKc | 9300.AA | S_TKc | 48-288 | 15 | 8.1e-09 | -47.64 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 48-288
Range on HMM: 1-231/231
Sequence Identity: 15% (46 aa)
LRDVHII--------------YENQYYLIKRVENVNKCMYFTQVVPSDINNFDISSMNHENILQIHQE---DNIFIAEPMLMT----LQSYIYQQQ----
. . .| .... ||.. . . . |. .|.|| ... |.... .. . | .|| ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK---HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGL
---DVSHDLEQIIKQIVNFISFLHSQNLAHTELSTRNFLINEKLQIK------AVPLPQEGV---QYRAPERIIGYDVENMK-SEDMFQLGCIILELLAR
. ...||.. . ..||.. | | | |..| .|| | | . |.||| . | . |. .|||. |.|..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCG
KPVLESEDETNQMLKYSLFLGRPQEIIYRNIYHQLPDTSPVDIDKYLSNCDQKLVNLIPQLLVYDPEKRATIQQVQN---------YL
.| . . ..|.| . .. . ..| ..|..||||| |. .. . ..
YPPFP---QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | 9300.AA | RCK | 244-295 | 28 | 8.1e-09 | 23.81 | In-house | 252-298 (298) | Show / Hide |
Range on Protein: 244-295 Range on HMM: 252-298/298 Sequence Identity: 28% (15 aa) LPDTSPVDIDKYLSNCDQKLVNLIPQLLVYDPEKRATIQQVQNYLNQVYPSF .|. .. ......|| | ...|. .| .||.||.|.||. . .|.| FPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQ-----HPYF |
|||||||||
| Kinase | 9300.AA | CDK10 | 177-237 | 37 | 5.6e-08 | 23.56 | In-house | 166-225 (285) | Show / Hide |
Range on Protein: 177-237 Range on HMM: 166-225/285 Sequence Identity: 37% (23 aa) YRAPERIIGYDVENMKSEDMFQLGCIILELLARKPVLESEDETNQMLKYSLFLGRPQEIIY ||||| ..| .. . ||. .|||. |||. ||.. | |. || | | |. YRAPELLLGC-RTQTTAIDMWAVGCILGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIW |
|||||||||
| Kinase | 9300.AA | CDK | 199-283 | 27 | 1.5e-07 | 20.05 | In-house | 208-277 (284) | Show / Hide |
Range on Protein: 199-283 Range on HMM: 208-277/284 Sequence Identity: 27% (24 aa) LGCIILELLA---RKPVLESEDETNQMLKYSLFLGRPQEIIYRNIYHQLPDTSPVDIDKYLSNCDQKLVNLIPQLLVYDPEKRATIQQ .|||. |.. ||| . . |..|. | . ..| | | . .. .||| .|. ..|.|||.|| . .| VGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVT-KLPDY-----------------DLLNKMLCYDPKKRISAEQ |
|||||||||
| Kinase | 9300.AA | Ciliate-C3 | 130-170 | 41 | 1.8e-07 | 23.12 | In-house | 100-140 (140) | Show / Hide |
Range on Protein: 130-170 Range on HMM: 100-140/140 Sequence Identity: 41% (17 aa) QIIKQIVNFISFLHSQNLAHTELSTRNFLINEKLQIKAVPL || |||. | .|| |. | .. .| ||| | .|| . QISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF |
|||||||||
| Kinase | 9300.AA | MAPK | 199-283 | 26 | 6.4e-07 | 19.71 | In-house | 220-321 (328) | Show / Hide |
Range on Protein: 199-283 Range on HMM: 220-321/328 Sequence Identity: 26% (27 aa) LGCIILELLA-RKPVLESEDETNQMLKYSLFLGRPQEIIYRNIY---------HQL---PDTSPVDIDKYLSN----CDQKLVNLIPQLLVYDPEKRATI .||| |.| ||| . .| .|. . .|| | | ...| ..| | . ... .| ..| .. . ..|. ..|| ||.|| |. VGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITV QQ .. EE |
|||||||||
| Kinase | 9300.AA | MAK | 243-287 | 30 | 9.5e-07 | 17.04 | In-house | 301-349 (352) | Show / Hide |
Range on Protein: 243-287 Range on HMM: 301-349/352 Sequence Identity: 30% (15 aa) QLPDTSP---VDIDKYLSNCDQ-KLVNLIPQLLVYDPEKRATIQQVQNY ..|. | . ... ..|| | .. |. .| .||.||.| || | RFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKY |
|||||||||
| Kinase | 9300.AA | MOK | 177-288 | 26 | 1e-06 | 16.17 | In-house | 164-283 (283) | Show / Hide |
Range on Protein: 177-288 Range on HMM: 164-283/283 Sequence Identity: 26% (33 aa) YRAPERII--GYDVENMKSEDMFQLGCIILELLARKPVLESEDETNQMLKYSLFLGRPQEIIY-------RNIYHQLPDTSPVDIDKYLSNCDQKLVNLI ||||| .. || | ||. ||. |... .|. | |. | .| |.. | | . .. | |.| ..| .. .... YRAPECLLTDGYYTYQM---DMWSVGCVFYEIASLHPLFPGVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIM PQLLVYDPEKRATIQQV--QNYL .. |||. | | .|| | HKMCTYDPDERITAHQVIQHPYF |
|||||||||
| Kinase | 9300.AA | ERK7 | 177-283 | 28 | 3e-06 | 17.28 | In-house | 172-285 (292) | Show / Hide |
Range on Protein: 177-283 Range on HMM: 172-285/292 Sequence Identity: 28% (33 aa) YRAPERIIGYDVENMKSEDMFQLGCIILELLARKPVLESEDETNQMLKYSLFLGRPQEI--------IYRNIYHQLPDTSPVDIDKYLSNCDQKLVNLIP ||||| .| . | || .|||. |.| ||. ||. | ...|.. . |. .|.. . . .|. . .| . ..|. YRAPEILLG-SHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLK QLLVYDPEKRATIQQ .|||. |.|| |..| RLLVFNPKKRLTAEQ |
|||||||||
| Kinase | 9300.AA | Ciliate-A2 | 254-289 | 35 | 3.8e-05 | 14.15 | In-house | 236-272 (272) | Show / Hide |
Range on Protein: 254-289 Range on HMM: 236-272/272 Sequence Identity: 35% (13 aa) KYLSNCDQKLVNLIPQLLVYDPEKRA-TIQQVQNYLN ... | |.|. .| |.| .|| || .||| . .. QDYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHWH |
|||||||||
| Kinase | 9300.AA | Pkinase | 177-288 | 20 | 4.6e-05 | 18.99 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 177-288 Range on HMM: 177-293/293 Sequence Identity: 20% (27 aa) YRAPERIIGYDVENMKSEDMFQLGCIILELLARKPVLESEDETNQMLKYSLFLGR-------PQEIIYRNIYHQLPDTSPVDIDKYLS------------ |.||| | . . .. ||. .|||. |.| .. .| |. ....|.|. . .|. .| ....... YMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGR---------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFH NCDQKLVNLIPQLLVYDPEKRATIQQVQNY--L | .. . .| .| .||.|| |..|. . . NWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | 9300.AA | Ciliate-A2 | 133-166 | 42 | 0.004096 | 7.01 | In-house | 109-143 (272) | Show / Hide |
Range on Protein: 133-166 Range on HMM: 109-143/272 Sequence Identity: 42% (15 aa) KQIVNFISFLHSQNLAHTELSTRNFLINEKLQ-IK .|| | ||..| . .|| || ||. | || CQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIK |
|||||||||
| Kinase | 9300.AA | ERK7 | 131-166 | 30 | 0.016009 | 4.08 | In-house | 105-140 (292) | Show / Hide |
Range on Protein: 131-166 Range on HMM: 105-140/292 Sequence Identity: 30% (11 aa) IIKQIVNFISFLHSQNLAHTELSTRNFLINEKLQIK |. |... | ..|| |. | | | |.. . .| IMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVK |
|||||||||
| Kinase | 9300.AA | CDK10 | 265-288 | 34 | 0.222549 | 0.25 | In-house | 260-285 (285) | Show / Hide |
Range on Protein: 265-288 Range on HMM: 260-285/285 Sequence Identity: 34% (9 aa) NLIPQLLVYDPEKRATIQQV--QNYL .|. |..|.| |||| .. | RLLNFLFMYNPKKRATAEECLESSYF |
|||||||||