Gene n1194 (Tetrahymena)

n1194

Species: Tetrahymena
Alias: n1194, 1351.m00002, 1194
External Links:
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
n1194.AA Protein None 219 None Fasta, JSON
n1194.NA RNA None 657 None Fasta, JSON
n1194.kin_dom Protein Kinase Domain None 142 None Fasta, JSON

Protein domain

Protein domains of n1194.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n1194.AA Ciliate-C7 78-219 82 1.3e-108 349.18 In-house 1-143 (164) Show / Hide 
Range on Protein: 78-219
Range on HMM: 1-143/164
Sequence Identity: 82% (118 aa)

FRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQ-GTLTQILERNQNKRLN
||||||| |||||||||.||||| |||||||||.|||.|.|.||.|.||..|||.|.||||||.|..|||||||.||||.||| |||.||.|||||||||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

EISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVV
||||||||.||||||||||||.|.|||||||||||||.|||||
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVV
Pkinase n1194.AA Pkinase 75-216 28 1e-22 81.43 Pfam 1-146 (293) Show / Hide 
Range on Protein: 75-216
Range on HMM: 1-146/293
Sequence Identity: 28% (43 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG-----TLTQILER
|   | .|.|  | | .... .|. .||.| . .|.   . |. . ..  .|..|.|.. ..|..| |.| ||  .  |.|.  |.|      |  ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

NQNKRL--NEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGN
 .....   |  ...|.  |..||.|.||....  ||| .||||| .|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH
Kinase n1194.AA ULK 75-212 26 2.5e-18 60.66 In-house 1-164 (329) Show / Hide 
Range on Protein: 75-212
Range on HMM: 1-164/329
Sequence Identity: 26% (44 aa)

YSDFRFLGQGVQGLVLLAKDSKT----NMRVAIKGVQ----VRDPQ---GNLDEDLNNRVKQEVEILKKCRD---SPY----VVSLIDQFEGQQF--SYL
|.  . ||.|  | |  ... ||    |  ||.| ..     ....   |   . . . .|.|..|.||  .   ...    .| |.| || ...   |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI

VLTECQG-TLTQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILID
..  |.| .| |....|..        |||.|  ||..  .|..|. ..|.. .   |.| .||||.
IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIH
Kinase n1194.AA ULK 75-211 27 7.2e-18 60.03 In-house 1-159 (324) Show / Hide 
Range on Protein: 75-211
Range on HMM: 1-159/324
Sequence Identity: 27% (45 aa)

YSDFRFLGQGVQG-LVLLAKDSKT---NMRVAIKGVQ--------VRDPQGNLDEDLNNRVKQEVEILKKCR--DSPY--VVSLIDQFEGQ--QFSYLVL
|.  . ||.|  |  |  ... ||   |  ||.| ..         ... |   . . .  |.|..|.||     .|.  .| |.| || .   . |...
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM

TECQG-TLTQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILI
  |.| .| |....|..       |||.|  ||..  .|..|. ..|.. .   |.| .||||
EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI
Kinase n1194.AA CAMKL 75-216 27 1.5e-17 52.41 In-house 1-165 (297) Show / Hide 
Range on Protein: 75-216
Range on HMM: 1-165/297
Sequence Identity: 27% (45 aa)

YSDFRFLGQGVQGLVLLAKD-SKTNMRVAIKGVQVR----DPQGNLD------EDLNNRVKQEVEILKKCR--DSPYVVSLIDQFEGQQF------SYLV
|   . ||.|  | | ||.. . |. .|||| .  .    ||. .        |.   |...|..|.|. .    | ...| . .| ...       |||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LTECQGT---LTQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGN
.  |.|    | . .... ..|  . |  | .|   |  ...|.||.     |.| .|||.|..||
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGN
Kinase n1194.AA Ciliate-E2-Unclassified 75-216 21 6e-17 55.34 In-house 1-185 (352) Show / Hide 
Range on Protein: 75-216
Range on HMM: 1-185/352
Sequence Identity: 21% (40 aa)

YSDFRFLGQGVQGLVLLAKDSKTN-------MRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILK---------------KCRDSPYVVSLIDQFEGQQFS
|   . .||| .| | .....|..       | ....  |    . . ..   .. ..|....|               .  ..|..| ....|. .|  
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EI---MNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI

YLVLTEC-QGTLTQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKS-CLVNDLKMDNILIDYHG---N
|.|.  | .|.| |...               ..|.|.. |  |.     .|.  | ||| |.|.|  ..  |.| .|||.|  |   .
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYY
Kinase n1194.AA CAMK 80-215 19 1.6e-16 49.1 In-house 1-216 (425) Show / Hide 
Range on Protein: 80-215
Range on HMM: 1-216/425
Sequence Identity: 19% (43 aa)

FLGQGVQGLVLLAKDSKTN------------MRVAIKGVQV----------------RDPQGNLD------EDLNNRVKQEVEILKKCR------DSPYV
 ||.|  | | |... .|.             .|||| .                  .| ... .      .    .|..|.||.||..      | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLIDQFEG-------------------QQFSYLVL---TECQGT------LTQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSKSC
..|.. .|                    ... |.|.     |.|       .  | |. ..            .|..|  | .|   |.... |.||.  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LVNDLKMDNILIDYHG
   ||| .|||.|...
VHRDLKPENILLDDNN
Kinase n1194.AA Ciliate-E1 81-218 20 2.7e-16 49.9 In-house 1-149 (202) Show / Hide 
Range on Protein: 81-218
Range on HMM: 1-149/202
Sequence Identity: 20% (31 aa)

LGQGVQGLVLLAKDSKTN-MRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQ--FSYLVLTECQGTLTQILE---------
.|.| ...|. ||  ..|   ||.| ..... .   ......  |.. .|.|  .   |.. .||... .|  ........|. .|.. |.         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNY--NQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

--RNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV
  ..... ...   .. . .. .|| ..|..  .  |.|..||||.  || |
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYV
Kinase n1194.AA Ciliate-E2 75-211 20 7.6e-16 50.86 In-house 1-194 (365) Show / Hide 
Range on Protein: 75-211
Range on HMM: 1-194/365
Sequence Identity: 20% (40 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRVAIK-------------GVQ-VRDPQGNLDEDLNNRVKQEVEILKKCR---------------DSPYVVSLIDQ
|   . .||| .| | ..|. |.. ..|||             .|.       .. ..  . .|||  |... .               ..|... ... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--GQQFSYLVLTECQG-TLTQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKS-CLVNDLKMDNILI
|.   ..  |||.  ||| .| .... |          . |...|  ....   |.|               .| |.|||  ..  |.| .|||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF
Kinase n1194.AA STE 75-197 18 7.7e-16 52.51 In-house 1-171 (359) Show / Hide 
Range on Protein: 75-197
Range on HMM: 1-171/359
Sequence Identity: 18% (31 aa)

YSDFRFLGQGVQGLVLLAKDSK---------------TNMRVAIKGVQVRDPQGNLDE------------DLNNRVKQEVEILKKCRD-SPYVVSLIDQF
. . ...|.|  | | .|.. |               |. ..||| . ... . .  |            .  .....|..|.|||.. .|..|  .. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EGQ-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSK
.         .  ....  .  |.|..|..      ...|      .|..|   .... .| .| |||.||.
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH
Kinase n1194.AA CMGC 75-212 19 1.1e-15 47.1 In-house 1-218 (513) Show / Hide 
Range on Protein: 75-212
Range on HMM: 1-218/513
Sequence Identity: 19% (43 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMR--------------VAIKGVQVRDPQGN------LDEDLNNRVKQEVEILKKCR----------------DSPY
|   . .|.|  | |  ..| .|| .              |||| .  .    .      . . .. |   |..|||. .                . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVSLIDQFEGQQFS-----------------YLVLTECQGTLTQILERNQ-------NKRLNEIS------------AIKYA------NDIAQGLY--YI
.|.|.| |   .                   |||   .. .| |....||       .. |.|                ..         | .||   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSKS--CLVNDLKMDNILID
||.    .  |||  ||||.
HSHWGNIIHRDLKPENILIN
Kinase n1194.AA S_TKc 75-219 17 5.5e-08 -59.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 75-219
Range on HMM: 1-231/231
Sequence Identity: 17% (43 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRVAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG---TLTQILERNQ
|   | .|.|  | | .... ||. .|||| .              .....|..||||  . |..| |.| |.  .. |.|.  | |   .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NKR----LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILID------------------------------YHG----------------------
 ..    ..|  | .|.  |...| |.||.  .  ||| .|||.|                              | .                      
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPF

--------------------------------------------NAVV
                                               .
PQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF