Gene IRE-2 (S.moellendorffii)

IRE-2

Species: S.moellendorffii
Alias: IRE-2
External Links:
Annotation:

Classification

Group: Other
Family: IRE

Sequence

Name Sequence Type Origin Length Description Download
IRE-2.AA Protein None 629 None Fasta, JSON
IRE-2.NA RNA None 1890 None Fasta, JSON
IRE-2.kin_dom Protein Kinase Domain None 278 None Fasta, JSON

Protein domain

Protein domains of IRE-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRE-2.AA IRE 211-490 34 4.7e-86 292.21 In-house 1-292 (292) Show / Hide 
Range on Protein: 211-490
Range on HMM: 1-292/292
Sequence Identity: 34% (102 aa)

KIVIGYGSHGTRILEGKLDQRQ-VAVKSILSGFYHKASKEIAALI--ELDTHPNVVRYYSMEQDNDFVYIALERCSFNLETFILVHAAGADNRTEVNEFE
. ..|.|. ||   .|. . |. |||| ... |   .|.||..||  | |.||||.||| .|.| .|||.||| |  .|    .|  .   | .. .  .
NNILGRGCNGTLVFKGIWNGRIPVAVKQMQKEFNPFISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQD--YVEQKKRNNFINSSNNS

EKELQEILQQKLTLWDRSCLPSPLLMRLMRDVLEGLVHLHKLGYVHRDLKPQNVLILR-----SGTFLSAKISDMGISKRLNDGASGIDK--LTTGMGSS
......    .. .   .      .  |......|| ||| .. |||||||.|.||       .|  ....|||.| .|.|. | . .    .    |..
NNNNKNNNNNNNQWQIHI-----RMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNRFMISDFGLCKMLVEGRYSFTRNIRSGPTGTW

GWQAPEQIQG---ERQTRAVDMFSVGCLLYFCITGGQHPFG-GRLERDMNIVSGKMDLFAVDHYPEAI-----DIISSLLAMDPKDRPTSMQVKLHPFF
||..||..|.   .| |..|| || || .|. .|.||||||  .| |  ||..||..|    | ..       | |.. ...||..||| ...  ||||
GWHPPEMLQEFCQKRKTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYNLDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKECLNHPFF
S_TKc IRE-2.AA S_TKc 208-490 25 1.4e-43 152.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 208-490
Range on HMM: 1-231/231
Sequence Identity: 25% (74 aa)

TISKIVIGYGSHGT-RILEGKLDQRQVAVKSILSGFYHKASKEIAALIELDTHPNVVRYYSMEQDNDFVYIALERCSFNLETFILVHAAGADNRTEVNEF
     .|| |. |. .    | ..|.||.| |      .. .||. | .   |||.|..| . || |..|. .| |. .|                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDL--------------------

EEKELQEILQQKLTLWDRSCLPSPLLMRLMRDVLEGLVHLHKLGYVHRDLKPQNVLILRSGTFLSAKISDMGISKRLNDGASGIDKLTTGMGSSGWQAPE
   .| ...... .   |. .|     ..|. ....| ..|..| .||||||.|.|. .       ||.| |....|          ||  |.  . |||
--GDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------TTFCGTPWYMAPE

QIQGERQTR-AVDMFSVGCLLYFCITGGQHPFGGRLERDMNIVSGKMDLFAVDHYPEAIDIISSLLAMDPKDRPTSMQVKL-------HPFF
 .     .. ..|. |.||.|| ... |. ||   ... ....            |||.|.|. .| .||..|||  ..         ||.|
VL---GYGKCKCDWWSCGCILYEMLC-GYPPFP-QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRE-2.AA Pkinase 227-490 25 9.6e-42 148.68 Pfam 21-293 (293) Show / Hide 
Range on Protein: 227-490
Range on HMM: 21-293/293
Sequence Identity: 25% (79 aa)

KLDQRQVAVKSILSGFYHKASK-------EIAALIELDTHPNVVRYYSMEQDNDFVYIALERCSFNLETFILVH----AAGADNRTEVNEFEEKELQEIL
| ....|||| |     ..  .       ||. . .|  |||.||.| . .|.| .|. .| |   |.  .  .    .                     
KGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYIST---------------------

QQKLTLWDRSCL--PSPLLMRLMRDVLEGLVHLHKLGYVHRDLKPQNVLILRSGTF---LSAKISDMGISKRLNDGASGIDKLTTGMGSSGWQAPEQIQ-
      |.. |.  .   . . |. .|.|| ..|. | .||||||.|.|| . |.    .  ||.| |..| ..        .||  |.... ||| |. 
------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV--KICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRG

GERQTRAVDMFSVGCLLYFCITGGQHPFGGR--------LERDMNIVSGKMDLFAVDHY--------------------PEAIDIISSLLAMDPKDRPTS
|.  ...|||.|.||.||  .. |. || |.        ...  .| ... .      .                    .|..|.|...|..|||.||| 
GQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

MQVKLHPFF
.|.. ||.|
EQILQHPWF
Kinase IRE-2.AA CAMK 334-490 20 2.4e-37 117.41 In-house 183-425 (425) Show / Hide 
Range on Protein: 334-490
Range on HMM: 183-425/425
Sequence Identity: 20% (49 aa)

RLMRDVLEGLVHLHKLGYVHRDLKPQNVLILRSGTF--------------LSAKISDMGISKRLNDGASGI--------------------DKLTTGMGS
|..| ..... ..|... ||||||| |.|.  ...                  ||.| | ......| .                      .|..|  |.
RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGT

SGWQA-PEQIQG--------------ERQTRAVDMFSVGCLLYFCITGGQHPFGGR---------------LERDMNIVSGKM--DLFAVDHYP------
 .  | || ..|              .  ....|| |.|..||.. .|   || |                 |   .| .||   . . ... .      
PEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCG-YPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPE

---------------EAIDIISSLLAMDPKDRPTSMQVKLHPFF
               |..| |...|  ||..|.|  |.. ||..
WWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase IRE-2.AA Ciliate-E2 339-490 21 7.3e-34 113.62 In-house 169-365 (365) Show / Hide 
Range on Protein: 339-490
Range on HMM: 169-365/365
Sequence Identity: 21% (46 aa)

VLEGLVHLHKLG-YVHRDLKPQNVLILRSGTFLSAKISDMGISKRLND---------------GASGIDKLTTG--------------MGSSGWQAPEQI
....| .||. .  .|||.||.|.|.         ||.|.|.||...|                 .. .. |.|               |. | .||| .
IILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL

Q---------GERQTRAVDMFSVGCLLYFCITGGQHPFGGRLERDMNIVSG-KMDLF-----------------AVDHYPEAIDIISS----LLAMDPKD
.         ... . ..|..|.|..||....| ..||       ...    | |..                   .. .|..|.|.     .|  ||. 
NGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG-KPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEK

RPT-SMQVKLHPFF
|.|   |.. ||.|
RITGWEQILNHPWF
Kinase IRE-2.AA Ciliate-E2-Unclassified 259-490 22 3.1e-29 98.55 In-house 80-352 (352) Show / Hide 
Range on Protein: 259-490
Range on HMM: 80-352/352
Sequence Identity: 22% (66 aa)

HPNVVRYYSMEQDNDFVYIALERC-SFNLETFILVHAA----GAD--NRTEV-NEFEEKELQ---EILQQKLTLWDRSCLPSPLLMRLMRDVLEGLVHLH
||..|... ..|| . .|| .| |   .|. .|         | |  ....  ..|.|.. .   .                    .... .|.|| .||
HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKA-------------------KFYFAQILQGLEYLH

KLG-YVHRDLKPQNVLILRSGTFLSAKISDMGISKRLN-----DGASG--------IDKLTTGMGSSGWQ----APEQIQGERQT----RAVDMFSVGCL
. .  .|||.||.|.|.  .|  .  ||.| ||||...     |  ..         ....| .|. . .    ||| .||. .      ..|..|.|..
HKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVI

LYFCITGGQHPFGGRL------------------ERDMNIVSGKMDLFA-------VDHYPEAIDIIS----SLLAMDPKDRPTSMQVKLHPFF
||....|  .||...                   .   ||  .. . .         .  |||.|.|.    ..|  .|. |.|  |.. ||.|
LYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase IRE-2.AA TKL 214-488 14 1.4e-24 85.39 In-house 1-364 (364) Show / Hide 
Range on Protein: 214-488
Range on HMM: 1-364/364
Sequence Identity: 14% (59 aa)

IGYGSHGTRILEGKLDQ----------RQVAVKSILSGF----------------------------YHKASKEIAALIELDT-HPNVVRYYSMEQDNDF
|| |. |  .  ||. .          . |||| . |                                .  .|  ... . . |||.|...   .....
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------VYIALERCSFNL-ETFILVHAAGADNRTEVNEFEEKELQEILQQKLTLWDRSCLPSPLLMRLMRDVLEGLVHLHKLG--------YV
              .|  | |.    . ...                                      ....|...|.  |. .||  .         .
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPII

HRDLKPQNVLILRSGT-----------FLSAKISDMGISKRLNDGASGID----------------KLTTGMGSSGWQAPEQIQGE--------------
|||||..|.|. . .|              .||.|.|.|....   .  |                .. |  |. .| ||| ..|.              
HRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCK

--RQTRAVDMFSVGCLLYFCITGGQHPFGGRLER------------DMNIVSGKMDLFA------------VDHYPEAIDIISSLLAMDPKDRPTSMQVK
    . ..|..| | .|. ..|. . |. .  ..             |... |.  .               |  |. ....    ..||..||.  ...
GFEYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEIL

LHP
 . 
KRL
Kinase IRE-2.AA STE 337-426 30 1.7e-23 79.86 In-house 158-258 (359) Show / Hide 
Range on Protein: 337-426
Range on HMM: 158-258/359
Sequence Identity: 30% (33 aa)

RDVLEG-LVHLHKLGYVHRDLKPQNVLILRSGTFLSAKISDMGISKRLND-GA------------SGIDKLTTGMGSSGWQAPEQIQGERQT------RA
|..|.| | .||.....|||.||.|.|.        .|..| |....|.| .|            ..  | .|  |.  | ||| ||...|.      . 
RQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTK

VDMFSVGCLL
.|. |.||..
CDIWSLGCTI
Kinase IRE-2.AA Ciliate-E2a 333-432 25 6e-22 61.42 In-house 104-212 (275) Show / Hide 
Range on Protein: 333-432
Range on HMM: 104-212/275
Sequence Identity: 25% (28 aa)

MRLMRDVL-EGLVHLHKLGYVHRDLKPQNVLIL-RSGTF---LSAKISDMGISKRLNDGASGID-KLTTGMGSSGWQA------PEQIQGERQTRAVDMF
...|.  | .|| ..|.....||||||.|.|.  .| .    .  ||.|.| ... ..    .  .. .  |. |  |      .| ..... .  .||.
CDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD---EKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW

SVGCLLYFCITG
|.|. .|. ..|
SCGVIFYILLCG
Kinase IRE-2.AA ULK 336-490 23 5.1e-19 64.16 In-house 132-324 (324) Show / Hide 
Range on Protein: 336-490
Range on HMM: 132-324/324
Sequence Identity: 23% (45 aa)

MRDVLEGLVHLHKLGYVHRDLKPQNVLILRSGTF---------LSAKISDMGISKRLNDGASGIDKLTTGM------GSSGWQAPEQIQ----GERQT-R
... ..|. .||| ...|||.|||| ||    .            .||.| | .| ....    ....|        |.    ||. .|    .. ..  
FKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDY

AVDMFSVGCLLYFCITGGQHPFGGRLERDMN----------------IVSGKMDLF---AVDHY-PEAIDIISSLLAMDPKDRPTSMQVKLHPFF
 .|..|.||..| ...|   || ..  .| .                |   . .     . ..  || .|.|. .|  |.||| .  ..  ||.|
KCDIWSLGCIFYEMLYGKY-PFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase IRE-2.AA ULK 336-490 22 1.7e-17 57.68 In-house 136-329 (329) Show / Hide 
Range on Protein: 336-490
Range on HMM: 136-329/329
Sequence Identity: 22% (45 aa)

MRDVLEGLVHLHKLGYVHRDLKPQNVLILRSGTF---------LSAKISDMGISKRLNDGASGIDKLTTGM------GSSGWQAPEQIQ----GERQT-R
... |.|. .||| ...|||.||||.||    .            .||.| | .| ....   .. ..|        |.    ||. .|    .. ..  
FKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDY

AVDMFSVGCLLYFCITGGQHPFGGRLERDMN------IVSG------KMDLFAVDHY---------PEAIDIISSLLAMDPKDRPTSMQVKLHPFF
 .|..|.||..| ...|   || .   .| .       .        ... .  . .         || .|.|. .|  |.||| .  ..  ||.|
KCDIWSLGCIFYEMLYGKP-PFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase IRE-2.AA CMGC 305-427 16 1e-14 43.87 In-house 135-326 (513) Show / Hide 
Range on Protein: 305-427
Range on HMM: 135-326/513
Sequence Identity: 16% (33 aa)

EFEEKELQEILQQ-----------KLTLWD------------RSCLPSPLLMRLMRDVLEGLV--HLHKLG--YVHRDLKPQNVLILRSGTF--------
|. .. | .....           .|.                 ...  .    |. .|.||   ..|. .   .||||||.|.||   ..         
EYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKS

---------LSAKISDMGISKRLND-------------------GASGIDKLTTGMGSSGWQAPEQIQGERQ----------TRAVDMFSVGCLLY
            || | | .. ...                   . .    .|.   .    ||| . | ..          | ..|| |||| ..
EDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFA
Kinase IRE-2.AA TyrKc 208-490 20 2.5e-12 -23.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 208-490
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

TISKIVIGYGSHGTRILEGKLDQRQVAVKSILSGFYHKA-SKEIAALIEL-DTHPNVVRYYSMEQDN-------DFVYIALERCSF-NLETFILVHAAGA
   . ..| |  | .. .|... .|||||.. ..  ...  .|.  . .|   |||.|| |    .        . ..| .| ..  .|  ..  |    
ITLGKKLGEGAFG-EVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

DNRTEVNEFEEKELQEILQQKLTLWDRSCLPSPLLMRLMRDVLEGLVHLHKLGYVHRDLKPQNVLILRSGTFLSAKISDMGISKRLNDG-----ASGIDK
                             |. . |   . .. .|  .||. ...||||   |.|. . .    .|||| | |. . |.     ..   .
-----------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYR

LTTGMGSSG-----WQAPEQIQGERQTRAVDMFSVGCLLYFCITGGQHPFGG------RLERDMNIVSGKMDLFAVDH--------YPEAI-DIISSLLA
 ... |. .     | ||| |.  . | . | .| | ...   | || |  |        .. .. |   . .   ..         |... .|...  .
KKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

MDPKDRPTSMQVKLHPFF
 ||.||||  ..  | .|
EDPEDRPTFSEI--HECF
Kinase IRE-2.AA CMGC 461-490 43 3.4e-10 28.73 In-house 484-513 (513) Show / Hide 
Range on Protein: 461-490
Range on HMM: 484-513/513
Sequence Identity: 43% (13 aa)

PEAIDIISSLLAMDPKDRPTSMQVKLHPFF
|.||| .. .| .||..|.|  |   ||.|
PQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase IRE-2.AA Ciliate-E2a 462-490 41 4e-08 20.03 In-house 247-275 (275) Show / Hide 
Range on Protein: 462-490
Range on HMM: 247-275/275
Sequence Identity: 41% (12 aa)

EAIDIISSLLAMDPKDRPTSMQVKLHPFF
|..|... .|  ||| |.|  |   ||.|
ECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase IRE-2.AA ULK 208-290 21 8.9e-08 23.32 In-house 1-111 (329) Show / Hide 
Range on Protein: 208-290
Range on HMM: 1-111/329
Sequence Identity: 21% (24 aa)

TISKIVIGYGSHGTRILEGK-LDQ-----RQVAVKSIL----SGFYHK---------ASKEIAALIELD-------THPNVVRYYSMEQDNDF--VYIAL
 . . ..| || | .  .|.  ..      .||.| |.    . ...            .||  . .|.       .|||.|..| . .. ..  .|| .
YCLNHCLGKGSFG-KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

ERCSF-NLETFI
| |   .||..|
EYCNGGDLEQYI
Kinase IRE-2.AA STE 461-490 43 6e-06 17.17 In-house 328-359 (359) Show / Hide 
Range on Protein: 461-490
Range on HMM: 328-359/359
Sequence Identity: 43% (14 aa)

PEAIDIISSLLAMDPKDRPTSMQVKL--HPFF
|| .| |.  | .||..|||. |     |||.
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase IRE-2.AA STE 209-280 17 9e-06 16.42 In-house 1-117 (359) Show / Hide 
Range on Protein: 209-280
Range on HMM: 1-117/359
Sequence Identity: 17% (20 aa)

ISK-IVIGYGSHGTRILE-----------GKL-----DQRQVAVKSIL--------------------SGFYHKASKEIAALIELDT-HPNVVRYYSMEQ
  .  .|| |. ||  .            |..      .. .|.| .                     .    .  |||  . ...  |||.|.|| .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DN-------DFVYIALE
..       | ..|..|
KEGHNHKNDDELWICME
Kinase IRE-2.AA Ciliate-E2 208-283 16 1.2e-05 15.4 In-house 1-117 (365) Show / Hide 
Range on Protein: 208-283
Range on HMM: 1-117/365
Sequence Identity: 16% (19 aa)

TISKIVIGYGSHG-----TRILEGKL-------------------DQRQVAVKSILSGFYHKASKEIAALIELDT---------------HPNVVRYYSM
 .   .|| |..|     ......|.                   .. ..|.|..        ..||  . |..                |||....|  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

EQ--DNDFVYIALERCS
 |  |.. .|. .| |.
FQEKDDNNIYLVMEYCQ
Kinase IRE-2.AA ULK 248-290 30 3.5e-05 14.41 In-house 59-108 (324) Show / Hide 
Range on Protein: 248-290
Range on HMM: 59-108/324
Sequence Identity: 30% (15 aa)

KEIAALIELD--THPN--VVRYYSMEQDNDF--VYIALERCSF-NLETFI
.||  . .|.   |||  .|..| . .. ..  .|| .| |   .||..|
NEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYI
Kinase IRE-2.AA CAMK 213-283 13 0.000359 8.55 In-house 1-143 (425) Show / Hide 
Range on Protein: 213-283
Range on HMM: 1-143/425
Sequence Identity: 13% (20 aa)

VIGYGS-----HGTRILEGKLDQ--------RQVAVKSIL------------------------------SGFYHK-ASKEIAALIELDT------HPNV
..| ||      ..... ... .        ..||.| |                               ...  |   .||. .  |        |||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYYSMEQD-------------------NDFVYIAL---ERCS
.. | . .|                   ....|. .   | ||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCS
Kinase IRE-2.AA CMGC 227-290 17 0.002556 5.73 In-house 35-145 (513) Show / Hide 
Range on Protein: 227-290
Range on HMM: 35-145/513
Sequence Identity: 17% (19 aa)

KLDQRQVAVKSILSGFYH--------------KASKEIAALIEL----------------DTHPNVVRYYSMEQDND-----------------FVYIAL
. ....||.| | . ||.              .|  ||  | .|                . |.|.|. | . ....                  .|.  
HETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVF

ERCSFNLETFI
| .  .|  .|
EYMDHDLYQYI
Ribonuc_2-5A IRE-2.AA Ribonuc_2-5A 495-624 43 2.4e-64 224.88 Pfam 1-137 (137) Show / Hide 
Range on Protein: 495-624
Range on HMM: 1-137/137
Sequence Identity: 43% (59 aa)

QRLQFLITASDRVEREDREASSAVLTALEAVAPTALG-GAWDEKLDPLLINNLGRY-RQ---YNYQAVRDLLRVIRNKANHYREL-PADVQQILGSIPQG
.||.||. .|||.| |||.  | .| |||. .. ..| | |..|.|. .....|.| |    |..  ||||||..||| .||.|. |.....|||..| |
KRLRFLCDVSDRFEIEDRDPPSPILQALERTSRCVVGFGDWHKKIDKAFMDDMGKYYRKRKNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLPDG

YESYFRTRFPKLLMEVYKVIAD-HCWEEEMFQPYFSE
. .||  |||.|||..|.|... || .|| |..|.. 
FLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYKP
PUG IRE-2.AA PUG 555-609 33 1.1e-18 69.32 SMART 1-66 (66) Show / Hide 
Range on Protein: 555-609
Range on HMM: 1-66/66
Sequence Identity: 33% (22 aa)

QAVRDLLRVIRNKANHYREL--------PADVQQILGSIPQGYESYFRTRFPKLLM---EVYKVIA
 .||||||..||...|.||.        ...... .|..| | | ||  .||.|..   |.| .. 
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK