VPS15-2

Species: S.moellendorffii
Alias: VPS15-2
External Links:
Annotation:

Classification

Group: Other
Family: VPS15

Sequence

Name Sequence Type Origin Length Description Download
VPS15-2.AA Protein None 1376 None Fasta, JSON
VPS15-2.NA RNA None 4128 None Fasta, JSON
VPS15-2.kin_dom Protein Kinase Domain None 203 None Fasta, JSON

Protein domain

Protein domains of VPS15-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase VPS15-2.AA VPS15 27-295 47 4.1e-129 435.24 In-house 1-293 (296) Show / Hide
Range on Protein: 27-295
Range on HMM: 1-293/296
Sequence Identity: 47% (141 aa)

LVLKEVIGKSERFFKAILCVHDEGLLLVKVYFKRGDVLDLREHARKLNEIREQFRNVENSHVWPFQRWHETDKAAYLLRQYFFSNLHERLSTRPFLSTIQ
 . ..  | | ||.|     |.||.  |||. |. | . |. .  .. ||. ...     .. |.|.  |||||||. |||.  ||  |.||||||. | 
CHYVKNLG-STRFMKVCKAKHHEGYIVVKVFVKHDDTYSLEPYKQRIEEIKKNLMQHPAFNCCPYQKVIETDKAAYMMRQYVKHNLYDRISTRPFLQMIE

KKWLAFQLLHAVKQSHDRG-VCHGDIKCENVLVTSWNWIYLTDFASFKPTYIPDDNPADFSFFFDTGGRRRCYLAPERFY-----DPKTES---------
||| |||.| |..|.| .| ||||||| ||.|||||||.||||||.|||.|.| ||||||.||||| .|| ||.|||||.     | . .          
KKWIAFQTLCALEQCHKQGNVCHGDIKSENILVTSWNWCYLTDFACFKPCYLPEDNPADFTFFFDTSRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHTD

----PVSP--GGPLTPSMDMFSLGCVIAELFLEG-QALFDLSQLLGYRKRLYDPL--PSLEKISDTGIKNMILQMIHIV-PESRLSCDDYLETW
       |  .| |||.||.||.||||||||.|| |..||.|||. ||.  |.|.    .||| |. |.|....||... |. |.||..||  |
SIDRQQNPWLFGELTPAMDIFSAGCVIAELFCEGDQPPFDYSQLCKYRSGEYHPNREQIMEKIQDEHIRNLCHHMIQKDNPMKRMSCEEYLNKW

Kinase VPS15-2.AA S_TKc 27-296 16 7.5e-13 11.58 SMART 1-231 (231) Show / Hide
Range on Protein: 27-296
Range on HMM: 1-231/231
Sequence Identity: 16% (49 aa)

LVLKEVIGKSERFFKAILCVHDE--GLLLVKVYFKRGDVLDLREHARKLNEIREQFRNVENSHVWPFQRWHETDKAAYLLRQYFFS---NLHERLSTRPF
  . ..|||   | |  .|.| .   .  .|.              . ..||.   .     ..  .  . .. .  |.   |      .|....  |. 
YEILRKIGK-GAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSTIQKKWLAFQLLHAVKQSHDRGVCHGDIKCENVLVTSWNWIYLTDF--ASFKPTYIPDDNPADFSFFFDTGGRRRC----YLAPERFYDPKT
      ..  . . .. |.. |..  |..|..| |.| ||.|...   | ..||  | .                     .  |    |.||| .     
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------TTFCGTPWYMAPEVL-----

ESPVSPGGPLTP-SMDMFSLGCVIAELFLEGQALFDLSQLLGYRKRLYDPLPSLEKISDTGIKNMILQMIHIVPESRLSCDDYLE--------TWA
        . .. . |. |.||...|..  |. .|.  |.    |..          |. ..  .| .. .  || |... . |.         | 
--------GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase VPS15-2.AA CMGC 111-169 15 3.2e-09 25.47 In-house 140-248 (513) Show / Hide
Range on Protein: 111-169
Range on HMM: 140-248/513
Sequence Identity: 15% (17 aa)

NLHERLSTRPF---------LSTIQ------------KKWLA------FQLLHAVK--QSHDRG--VCHGDIKCENVLVTSWNW----------------
.|.. .   .|         ||  .            .| .       .|.| ..|    | ..  ..| |.| ||.|... .                 
DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQ

----IYLTDF
    . . ||
KNGRLKICDF

Kinase VPS15-2.AA Ciliate-E2-Unclassified 111-232 16 6e-09 27.21 In-house 107-260 (352) Show / Hide
Range on Protein: 111-232
Range on HMM: 107-260/352
Sequence Identity: 16% (29 aa)

NLHERLSTRPF-----------------LSTIQKK-----WLAFQLLHAVKQSHDRG-VCHGDIKCENVLVTSWN---WIYLTDFASFK-----------
.|.. .. |..                 ..  | |      .. |.| . .. |  . ..| |||.||.|... .    | ..|| ..|           
DLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTN

-------------------PTYIPDDNPADFSFFFDTGGRRRCYLAPERFYDPKTESPVSPGGPLTPSMDMFSLGCVI
                   | |.|                   |.||| .   . . . .       . |..|||...
QQQKMQIWKQQMMWTFCGTPNYMP-Q-----------------YTAPEVLQGQNYDHSKA------YKCDIWSLGVIL

Kinase VPS15-2.AA NIM1 133-169 48 8.7e-09 21.96 In-house 108-144 (258) Show / Hide
Range on Protein: 133-169
Range on HMM: 108-144/258
Sequence Identity: 48% (18 aa)

QLLHAVKQSHDRGVCHGDIKCENVLVTSWNWIYLTDF
|.. |||  | |.. | ||| |||. || | . . ||
QIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDF

Kinase VPS15-2.AA CAMK 133-169 25 1.2e-07 19.99 In-house 187-240 (425) Show / Hide
Range on Protein: 133-169
Range on HMM: 187-240/425
Sequence Identity: 25% (14 aa)

QLLHAVKQSHDRGVCHGDIKCENVLVTSWN----------------W-IYLTDF
|.. ||.  |.....| |.|.||.|... |                . | ..||
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF

Kinase VPS15-2.AA Ciliate-C3 133-169 40 3.1e-07 22.29 In-house 104-140 (140) Show / Hide
Range on Protein: 133-169
Range on HMM: 104-140/140
Sequence Identity: 40% (15 aa)

QLLHAVKQSHDRGVCHGDIKCENVLVTSWNWIYLTDF
|.| |.   |.  . ||||| .|.|. | . | . ||
QILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF

Kinase VPS15-2.AA MARK 133-158 42 3.2e-07 19.83 In-house 112-137 (262) Show / Hide
Range on Protein: 133-158
Range on HMM: 112-137/262
Sequence Identity: 42% (11 aa)

QLLHAVKQSHDRGVCHGDIKCENVLV
|...||.  |.....| |||.||.|.
QIVSAVNYCHSKNIVHRDIKPENILI

Kinase VPS15-2.AA CMGC 220-248 25 7.7e-07 17.51 In-house 313-363 (513) Show / Hide
Range on Protein: 220-248
Range on HMM: 313-363/513
Sequence Identity: 25% (13 aa)

TPSMDMFSLGCVIAELFLE-------GQALFD---------------LSQL
|...|| |.||..||...        |. ||                . ||
TTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQL

Kinase VPS15-2.AA CDKL 132-169 38 1e-06 18.49 In-house 105-143 (286) Show / Hide
Range on Protein: 132-169
Range on HMM: 105-143/286
Sequence Identity: 38% (15 aa)

FQLLHAVKQSHDRGVCHGDIKCENVLVT-SWNWIYLTDF
.|.| |... |   . | ||| || |.| .   . | ||
WQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDF

Kinase VPS15-2.AA CDK 128-169 25 2e-06 16.21 In-house 111-157 (284) Show / Hide
Range on Protein: 128-169
Range on HMM: 111-157/284
Sequence Identity: 25% (12 aa)

KWLAFQLLHAVKQSHDRGVCHGDIKCENVLVTSWNW-----IYLTDF
|.. .||| ..   |.... | |.|. | |...        . ..||
KCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADF

Kinase VPS15-2.AA ERK7 98-169 31 3.8e-05 13.21 In-house 73-144 (292) Show / Hide
Range on Protein: 98-169
Range on HMM: 73-144/292
Sequence Identity: 31% (23 aa)

DKAAYLLRQYFFSNLHERLSTRPFLSTIQKKWLAFQLLHAVKQSHDRGVCHGDIKCENVLVTSWNWIYLTDF
|.  ||   .  . ||        |  | |.   .||| |.|  |   | | |.|  |.|. |   . . ||
DRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDF

Kinase VPS15-2.AA ERK7 220-243 41 0.000258 10.31 In-house 185-207 (292) Show / Hide
Range on Protein: 220-243
Range on HMM: 185-207/292
Sequence Identity: 41% (10 aa)

TPSMDMFSLGCVIAELFLEGQALF
|.  || |.||...|. | |...|
TKGVDMWSIGCILGEM-LRGKPMF

Kinase VPS15-2.AA CDK 220-243 38 0.001207 7.35 In-house 200-225 (284) Show / Hide
Range on Protein: 220-243
Range on HMM: 200-225/284
Sequence Identity: 38% (10 aa)

TPSMDMFSLGCVIAELFL--EGQALF
... || |.||..||.|.   ...||
GTPIDMWSVGCIFAEMFTDVTRKPLF

Kinase VPS15-2.AA Pkinase 198-295 17 0.002868 12.64 Pfam 177-293 (293) Show / Hide
Range on Protein: 198-295
Range on HMM: 177-293/293
Sequence Identity: 17% (22 aa)

YLAPERFYDPKTESPVSPGGPLTPSMDMFSLGCVIAELFLEGQALFD-L------SQLLGYRKRLYDPLPSLEKISD--------------------TGI
|.|||          .  | . .|. ||.|.||...|... |. .|.        .|.  ...... ||.. .  ..                       
YMAPEV---------IRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

KNMILQMIHIVPESRLSCDDYLET--W
|  |  ...  |..|..... |.   .
KDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase VPS15-2.AA CDKL 221-243 39 0.009543 5.22 In-house 179-200 (286) Show / Hide
Range on Protein: 221-243
Range on HMM: 179-200/286
Sequence Identity: 39% (9 aa)

PSMDMFSLGCVIAELFLEGQALF
.. |. ..|||.||. . ||.|.
KPVDIWAIGCVMAEM-IDGQPLW

Kinase VPS15-2.AA Pkinase 142-169 34 0.059631 7.98 Pfam 125-156 (293) Show / Hide
Range on Protein: 142-169
Range on HMM: 125-156/293
Sequence Identity: 34% (11 aa)

HDRGVCHGDIKCENVLVTSWNWI----YLTDF
|..|..| |.| ||.|. . . |     ..||
HSMGIIHRDLKPENILIDNNGHIDACVKICDF

HEAT VPS15-2.AA HEAT 473-503 29 1.5e-05 23.1 Pfam 1-31 (31) Show / Hide
Range on Protein: 473-503
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

IVPFVAALLSDSAAIVRCAALQTLCNVLSMV
|.|..  .|.|. . ||.||...|..... .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT VPS15-2.AA HEAT 518-548 25 0.692321 6.93 Pfam 1-31 (31) Show / Hide
Range on Protein: 518-548
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

IFPLLSMLPDDPEESVRICYADCIHKIAGTA
|.|.|  . .||...||   . |. ...  .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT VPS15-2.AA HEAT 625-655 29 2.291404 5.13 Pfam 1-31 (31) Show / Hide
Range on Protein: 625-655
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

LLPVLPAFLNDRDKQLRALFFEQIVHVCIFV
.||.|   ||| | . |.  .. ....| ..
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT VPS15-2.AA HEAT 664-694 32 0.036877 11.34 Pfam 1-31 (31) Show / Hide
Range on Protein: 664-694
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

LLPYLEQALSNVEEPVIVNALECLAALCVYK
.||.| ..|.  .. |  .|..||..|| . 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT VPS15-2.AA HEAT 711-734 25 5.0214 3.95 Pfam 8-31 (31) Show / Hide
Range on Protein: 711-734
Range on HMM: 8-31/31
Sequence Identity: 25% (6 aa)

LLCHPSQWVRRAAITLVAASGSNL
.|..|.  ||.||.  ...  ...
CLNDPDWEVREAACWCLGQLCEHC

WD40 VPS15-2.AA WD40 974-1012 27 4.8e-13 40.16 Pfam 1-39 (39) Show / Hide
Range on Protein: 974-1012
Range on HMM: 1-39/39
Sequence Identity: 27% (11 aa)

GVLVSHLHEHQRAVNQVAVSSD-NSFFTSASDDGTVKVWD
. ... . .|. .|. .|.. |  ... |.|.|||...||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD

WD40 VPS15-2.AA WD40 973-1012 25 6.3e-11 43.55 SMART 1-46 (46) Show / Hide
Range on Protein: 973-1012
Range on HMM: 1-46/46
Sequence Identity: 25% (12 aa)

RGVLVSHLHEHQR--AVNQVAVSSDN------SFFTSASDDGTVKVWD
   .|. .. |.   .|. |....|.      ... |.| |||...||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD

WD40 VPS15-2.AA WD40 1021-1061 18 0.044052 8.92 SMART 1-46 (46) Show / Hide
Range on Protein: 1021-1061
Range on HMM: 1-46/46
Sequence Identity: 18% (9 aa)

SFRSKLTYSFGQNE--RVLCLAMLSPD------QQVAAASSGGEIRVLC
. .   |.. | .   .|.|..  . .      ...|..|  | ||.  
T-KCVHTFK-GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD

WD40 VPS15-2.AA WD40 1024-1059 26 3.21742 3.25 Pfam 1-37 (39) Show / Hide
Range on Protein: 1024-1059
Range on HMM: 1-37/39
Sequence Identity: 26% (10 aa)

SKLTYSFGQN-ERVLCLAMLSP-DQQVAAASSGGEIRV
.|....|      | |.|   .  . .| .|  | ||.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRI

WD40 VPS15-2.AA WD40 1077-1114 16 1.025854 0.29 SMART 1-46 (46) Show / Hide
Range on Protein: 1077-1114
Range on HMM: 1-46/46
Sequence Identity: 16% (8 aa)

GISNVRRTDAQEG--SVLALQAFGG-------MLLYSTQKNG-LHLWD
  . |.  .. .|  .|....            .|.|   .| ...||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD

WD40 VPS15-2.AA WD40 1120-1158 20 0.005309 14.72 SMART 1-46 (46) Show / Hide
Range on Protein: 1120-1158
Range on HMM: 1-46/46
Sequence Identity: 20% (10 aa)

DAWLLKAKP-EQG--YVSALAADPSR------NWLVSGTSRGVLTLWD
.  ...  .  .|  .|.... .|.       |.|.||   | . .||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD

WD40 VPS15-2.AA WD40 1130-1158 30 0.061781 8.19 Pfam 10-39 (39) Show / Hide
Range on Protein: 1130-1158
Range on HMM: 10-39/39
Sequence Identity: 30% (9 aa)

QGYVSALAADPS-RNWLVSGTSRGVLTLWD
.. |...| .|. ...|.||   | . .||
THWVTCCAWHPDMGHYLASGSRDGTIRIWD

WD40 VPS15-2.AA WD40 1279-1292 42 0.001403 12.92 Pfam 26-39 (39) Show / Hide
Range on Protein: 1279-1292
Range on HMM: 26-39/39
Sequence Identity: 42% (6 aa)

VITGGTDCRIRLWD
...|. |. ||.||
LASGSRDGTIRIWD

WD40 VPS15-2.AA WD40 1257-1292 16 0.08557 7.1 SMART 1-46 (46) Show / Hide
Range on Protein: 1257-1292
Range on HMM: 1-46/46
Sequence Identity: 16% (8 aa)

LSDPPPRIP------GVRALLPTTAG------ASVITGGTDCRIRLWD
   .   ..      .|...     |        ...|. |. ||.||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD

WD40 VPS15-2.AA WD40 1349-1376 38 1.8e-08 27.0 Pfam 9-39 (39) Show / Hide
Range on Protein: 1349-1376
Range on HMM: 9-39/39
Sequence Identity: 38% (12 aa)

HRDSITSLAAASQ---LLISSSRDGTIKVWK
| ...|..| .     .|.|.||||||..|.
HTHWVTCCAWHPDMGHYLASGSRDGTIRIWD

WD40 VPS15-2.AA WD40 1336-1376 19 9.3e-05 23.06 SMART 1-46 (46) Show / Hide
Range on Protein: 1336-1376
Range on HMM: 1-46/46
Sequence Identity: 19% (10 aa)

SEVALAAVDMAGCHRD--SITSLAAASQ--------LLISSSRDGTIKVWK
.   ..  .   .|..  ..|...  .         .|.|.| ||||..|.
T-KCVHTFK---GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD