Egfr_Dmel MLLRRRNGPCPFPLLLLLLAH-CICIWPASA-----------------------------
ErbB4_Mmus MKLA---TGLW-VWGSLLMA--A----GTVQ-----------------------------
ErbB3_Mmus MSAI---GTLQ-VLGFLLS-L-A----RGSE-----------------------------
ErbB2_Mmus MELA---AWCRW--GFLLA-L-L----SPG------------------------------
EGFR_Mmus MRPS---GTARTTLLVLLTAL-C----AAGG-----------------------------
let-23_Cele MKFP---FLF--LFLIILIDTTI----DAASPTSTQGSVTVRRRQRKIVVRECMRYPPSI
ErbB4_Hsap MKPA---TGLW-VWVSLLVA--A----GTVQ-----------------------------
ErbB3_Hsap MRAN---DALQ-VLGLLFS-L-A----RGSE-----------------------------
ErbB2_Hsap MELA---ALCRW--GLLLA-L-L----PPG------------------------------
EGFR_Hsap MRPS---GTAGAALLALLAAL-C----PASR-----------------------------
EGFR_Spur MWRI---QQPK-R--I----V-C----T--Q-----------------------------
AqueK263_Aque ------------------------------------------------------------
AqueK264_Aque ML----------------------------------------------------------
AqueK265_Aque MQMM---LELQL------------------------------------------------
AqueK266_Aque MVFS---SNGQVE---------------P-------------------------------
Egfr_Dmel ----------------ARDRYARQNNRQRHQDIDRDRDRDRFLYRSSSAQNRQRGGANFA
ErbB4_Mmus ------------------------------------------------------------
ErbB3_Mmus ------------------------------------------------------------
ErbB2_Mmus ------------------------------------------------------------
EGFR_Mmus ------------------------------------------------------------
let-23_Cele GSILLIIPIFLTFFGNS-------------------------------------------
ErbB4_Hsap ------------------------------------------------------------
ErbB3_Hsap ------------------------------------------------------------
ErbB2_Hsap ------------------------------------------------------------
EGFR_Hsap ------------------------------------------------------------
EGFR_Spur ------------------------------------------------------------
AqueK263_Aque ------------------------------------------------------------
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque ------------------------------------------------------------
AqueK266_Aque ------------------------------------------------------------
Egfr_Dmel LGLGANGVTIPTSLEDKNKN-------EFVKGKICIGTKSRLSVPSN------KEHHYRN
ErbB4_Mmus ---------------------------PSASQSVCAGTENKLSSLSD------LEQQYRA
ErbB3_Mmus ---------------------------MGNSQAVCPGTLNGLSVTGD------ADNQYQT
ErbB2_Mmus ----------------------------AAGTQVCTGTDMKLRLPAS------PETHLDM
EGFR_Mmus ---------------------------ALEEKKVCQGTSNRLTQLGT------FEDHFLS
let-23_Cele -------------------NAQLWKRCVSPQDCLCSGTTNGISRYGT-------GNILED
ErbB4_Hsap ---------------------------PSDSQSVCAGTENKLSSLSD------LEQQYRA
ErbB3_Hsap ---------------------------VGNSQAVCPGTLNGLSVTGD------AENQYQT
ErbB2_Hsap ----------------------------AASTQVCTGTDMKLRLPAS------PETHLDM
EGFR_Hsap ---------------------------ALEEKKVCQGTSNKLTQLGT------FEDHFLS
EGFR_Spur ---------------------------IRGRPRVCTGTDQGTAKPYNSDNAGARQQYYEE
AqueK263_Aque -------------------------------ETICLGHSTSRVSQSQGDS---VSSILKD
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque ----------------------------FIIETICLGHSTNRVSQSQGGT---VSSILQD
AqueK266_Aque ---------------------------DCPLKSICLGHSTNRVSQSQGDS---VSSILQD
Egfr_Dmel LRDRYTNCTYVDGNLEL---------TWLPNEN----------------------LDLSF
ErbB4_Mmus LRKYYENCEVVMGNLEI---------TSI-EHN----------------------RDLSF
ErbB3_Mmus LYKLYEKCEVVMGNLEI---------VLT-GHN----------------------ADLSF
ErbB2_Mmus LRHLYQGCQVVQGNLEL---------TYL-PAN----------------------ASLSF
EGFR_Mmus LQRMYNNCEVVLGNLEI---------TYV-QRN----------------------YDLSF
let-23_Cele LETMYRGCRRVYGNLEI---------TWI-EANEIKKWRESTNSTVDPKNEDSPLKSINF
ErbB4_Hsap LRKYYENCEVVMGNLEI---------TSI-EHN----------------------RDLSF
ErbB3_Hsap LYKLYERCEVVMGNLEI---------VLT-GHN----------------------ADLSF
ErbB2_Hsap LRHLYQGCQVVQGNLEL---------TYL-PTN----------------------ASLSF
EGFR_Hsap LQRMFNNCEVVLGNLEI---------TYV-QRN----------------------YDLSF
EGFR_Spur LKDRYTNCTYVDGNLEI---------SFLHEQE----------------------YDLGF
AqueK263_Aque AYEQFCGSEYIEDNIVIRTGSGLVDISQP-LVE----------------------ANFSF
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque AYEQFCGCRYIKDNIVIQTGPTLVDANQT-LVE----------------------ANFSF
AqueK266_Aque AYEQFCGCRYIEDNIVIRTGSGLVDISQP-LVE----------------------ANFSF
Egfr_Dmel LDNIREVTGYILI-SHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTY---------
ErbB4_Mmus LRSIREVTGYVLV-ALNQFRYLPLENLRIIRGTKLY-----EDRYALAIFLNYRKD----
ErbB3_Mmus LQWIREVTGYVLV-AMNEFSVLPLPNLRVVRGTQVY-----DGKFAIFVMLNYNTN----
ErbB2_Mmus LQDIQEVQGYMLI-AHNRVKHVPLQRLRIVRGTQLF-----EDKYALAVLDNRDPLDNVT
EGFR_Mmus LKTIQEVAGYVLI-ALNTVERIPLENLQIIRGNALY-----ENTYALAILSNYGTN----
let-23_Cele FDNLEEIRGSLII-YRANIQKISFPRLRVIYGDEVF-----HDN-ALYIHKN--------
ErbB4_Hsap LRSVREVTGYVLV-ALNQFRYLPLENLRIIRGTKLY-----EDRYALAIFLNYRKD----
ErbB3_Hsap LQWIREVTGYVLV-AMNEFSTLPLPNLRVVRGTQVY-----DGKFAIFVMLNYNTN----
ErbB2_Hsap LQDIQEVQGYVLI-AHNQVRQVPLQRLRIVRGTQLF-----EDNYALAVLDNGDPLNNT-
EGFR_Hsap LKTIQEVAGYVLI-ALNTVERIPLENLQIIRGNMYY-----ENSYALAVLSNYDAN----
EGFR_Spur LSSIREVTGYILI-LLTYSRVIPLTNLRVIRGTKLY-----DDKYALYVALTFHTG----
AqueK263_Aque LYYVKEISGYLELNNIPSIERLSLPRLRLIRGRNLR-----SGRYSLLVSG---------
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque LYYVKEISGYLELNGIPSIERLSLPNLRIIRGRNLR-----SGRYSLLALG---------
AqueK266_Aque LYYVIEISGYLELNNIPSIERLSLPRLRLIRGRNLR-----SGRYSLLVSG---------
Egfr_Dmel --------SKMYTLEIPDLRDVLNGQVGFH---NNYNLCHM-RTIQWSEIVSNGTDAYYN
ErbB4_Mmus ------GNFGLQELGLKNLTEILNGGVYVD---QNKFLCYA-DTIHWQDIVRNPWPSNMT
ErbB3_Mmus ------SSHALRQLRFTQLTEILLGGVYIE---KNDKLCHM-DTIDWRDIVRVPD-A--E
ErbB2_Mmus TAAPGRTPEGLRELQLRSLTEILKGGVLIR---GNPQLCYQ-DMVLWKDVLRKNNQLAPV
EGFR_Mmus -------RTGLRELPMRNLQEILIGAVRFS---NNPILCNM-DTIQWRDIVQNVFMSNMS
let-23_Cele --------DKVHEVVMRELRVIRNGSVTIQ---DNPKMCYIGDKIDWKELLYDPDVQKVE
ErbB4_Hsap ------GNFGLQELGLKNLTEILNGGVYVD---QNKFLCYA-DTIHWQDIVRNPWPSNLT
ErbB3_Hsap ------SSHALRQLRLTQLTEILSGGVYIE---KNDKLCHM-DTIDWRDIVRDRD-A--E
ErbB2_Hsap TPVTGASPGGLRELQLRSLTEILKGGVLIQ---RNPQLCYQ-DTILWKDIFHKNNQLALT
EGFR_Hsap -------KTGLKELPMRNLQEILHGAVRFS---NNPALCNV-ESIQWRDIVSSDFLSNMS
EGFR_Spur -----DPTIATEEMWLTSLHEILKGDVYFH---QNNQLCYV-ETIAWDDMQPGL-VANIS
AqueK263_Aque ---------RIETLHMPSLTEISRGDVMLGSSSLNSYLCNT-RSINWTDIAPFPVSG-HQ
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque ---------KIQNLYMPNLTEISRGDVWFIS-RLNPYLCNT-RSINWIDIAPFPVIG-HR
AqueK266_Aque ---------RIETLYMPRLTEISRGDVLLGSSSLNSYLCNT-RSINWTDIAPFPVSG-HQ
Egfr_Dmel YD-----FTAPERECP--KCHE-SCT-HGCWGEGPKNCQKFSKLTCSPQCAGGRCYG---
ErbB4_Mmus LV-----STNGSSGCG--RCHK-SCT-GRCWGPTENHCQTLTRTVCAEQCD-GRCYG---
ErbB3_Mmus IV-----VKNNGGNCP--PCHE-VCK-GRCWGPGPEDCQILTKTICAPQCN-GRCFG---
ErbB2_Mmus DM-----DTNRSRACP--PCAP-TCKDNHCWGESPEDCQILTGTICTSGCA--RCKG---
EGFR_Mmus MD-----LQSHPSSCP--KCDP-SCPNGSCWGGGEENCQKLTKIICAQQCS-HRCRG---
let-23_Cele TTNSHQHCYQNGKSMA--KCHE-SCN-DKCWGSGDNDCQRVYRSVCPKSCS--QCFYSNS
ErbB4_Hsap LV-----STNGSSGCG--RCHK-SCT-GRCWGPTENHCQTLTRTVCAEQCD-GRCYG---
ErbB3_Hsap IV-----VKDNGRSCP--PCHE-VCK-GRCWGPGSEDCQTLTKTICAPQCN-GHCFG---
ErbB2_Hsap LI-----DTNRSRACH--PCSP-MCKGSRCWGESSEDCQSLTRTVCAGGCA--RCKG---
EGFR_Hsap MD-----FQNHLGSCQ--KCDP-SCPNGSCWGAGEENCQKLTKIICAQQCS-GRCRG---
EGFR_Spur MW-----DEHAQRNCSEHRCHE-SCN-GHCWGPGEEHCQILTLKDCSSTCD-YRCRG---
AqueK263_Aque FS-----RTD--------------------------------------------------
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque L------ETNGCSDS-----A-QG-PAGAMILTAVKHCHLIAIAITIVA-----------
AqueK266_Aque FS-----GTDGCSDIDIIDCNALGCSSGFCWCNDTDCCQTLSF-NCNCNN--SRCFRDGQ
Egfr_Dmel PKPRECCHLFCAGGCTGP------------------------------------TQKDCI
ErbB4_Mmus PYVSDCCHRECAGGCSGP------------------------------------KDTDCF
ErbB3_Mmus PNPNQCCHDECAGGCSGP------------------------------------QDTDCF
ErbB2_Mmus RLPTDCCHEQCAAGCTGP------------------------------------KHSDCL
EGFR_Mmus RSPSDCCHNQCAAGCTGP------------------------------------RESDCL
let-23_Cele TSSYECCDSACLGGCTGH------------------------------------GPKNCI
ErbB4_Hsap PYVSDCCHRECAGGCSGP------------------------------------KDTDCF
ErbB3_Hsap PNPNQCCHDECAGGCSGP------------------------------------QDTDCF
ErbB2_Hsap PLPTDCCHEQCAAGCTGP------------------------------------KHSDCL
EGFR_Hsap KSPSDCCHNQCAAGCTGP------------------------------------RESDCL
EGFR_Spur PTQADCCHRSCAGGCTNS------------------------------------SNAGCL
AqueK263_Aque -----GCND-LAQGFAGVMTLIAAKHYHLIAIATTIVVVSEMVQTYNVAIRSVLLVAVVM
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque ---SEMVQTYSVAIQS------------------------------------VLLVAVKV
AqueK266_Aque --NIHCCHPECVAGCSGY------------------------------------DNSQCF
Egfr_Dmel ACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPG----HLLR-DNG
ErbB4_Mmus ACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPH----NFVV-DSS
ErbB3_Mmus ACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPH----NFVV-DQT
ErbB2_Mmus ACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPY----NYLSTEVG
EGFR_Mmus VCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPR----NYVVTDHG
let-23_Cele ACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPP----ELLI-END
ErbB4_Hsap ACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPH----NFVV-DSS
ErbB3_Hsap ACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPH----NFVV-DQT
ErbB2_Hsap ACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPY----NYLSTDVG
EGFR_Hsap VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPR----NYVVTDHG
EGFR_Spur ACRQFSLDNTCVETCPRRYEYDRNTFTNVENPNFRYSYGSRCLKDCPN----NVLV-DGD
AqueK263_Aque ACKNVLDDGVCRERCPEQYIIDPFARTVIPNPLFKLEAKPLCVYSCPDPFRNNFLHEHGT
AqueK264_Aque ------------------------------------------------------FEL-GT
AqueK265_Aque ACKNVLNDGVCRERCPEQYIIDPDTRAVVLNPEFKFEAQPLCVSTCPA----MLFEL-GT
AqueK266_Aque ACKNVLNVGACQERCPNQFIINPFTRTFIPNPEFKLEAQPLCVSSCPD----MLFQV-DT
.
Egfr_Dmel ACVRSCPQDKMDKG-----GECVPCN-GPCPKTCPGVTV--------LHAGNIDSFRNCT
ErbB4_Mmus SCVRACPSSKMEVE-ENGIKMCKPCT-DICPKACDGIGTGSLMSAQTVDSSNIDKFINCT
ErbB3_Mmus FCVRACPADKMEVD-KNGLKMCEPCR-GLCPKACEGTGSGSR--YQTVDSSNIDGFVNCT
ErbB2_Mmus SCTLVCPPNNQEVTAEDGTQRCEKCS-KPCAGVCYGLGMEHLRGARAITSDNIQEFAGCK
EGFR_Mmus SCVRACGPDYYEVE-EDGIRKCKKCD-GPCRKVCNGIGIGEFKDTLSINATNIKHFKYCT
let-23_Cele VCVRHCSDGHHYDA-TKDVRECEKCRSSSCPKICTVDGH--------LTNETLKNLEGCE
ErbB4_Hsap SCVRACPSSKMEVE-ENGIKMCKPCT-DICPKACDGIGTGSLMSAQTVDSSNIDKFINCT
ErbB3_Hsap SCVRACPPDKMEVD-KNGLKMCEPCG-GLCPKACEGTGSGSR--FQTVDSSNIDGFVNCT
ErbB2_Hsap SCTLVCPLHNQEVTAEDGTQRCEKCS-KPCARVCYGLGMEHLREVRAVTSANIQEFAGCK
EGFR_Hsap SCVRACGADSYEME-EDGVRKCKKCE-GPCRKVCNGIGIGEFKDSLSINATNIKHFKNCT
EGFR_Spur NCVKVCGPGKKEQD-----NQCIPCE-GVCPSTCDGIGDDGALSSK---HIRSKQFDNCT
AqueK263_Aque QCVKDCPSNYMPVP-SNRTMRCVLCN-DTCPKECTGG-V--------FDYNDPGKLTGCT
AqueK264_Aque QCVEDCPSNYMPVV-NNGIMRCLSCD-GPCPQECTGG-V--------FDYNDPGKLTGCT
AqueK265_Aque QCVEDCPSNYMSVSGDNGTMRCVLCD-GPCPQECAGG-V--------FDYDVPGKLSGCT
AqueK266_Aque QCVKNCPSNYMPVA-NNGTMRCVLCN-DTCPKKCTGG-V--------FDYNNPGKLTGCT
*. * * * * * : *
Egfr_Dmel VIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFR
ErbB4_Mmus KINGNLIFLVTGIHGDP--Y------NAIDAIDPEKLNVFRTVREITGFLNIQSWPPNMT
ErbB3_Mmus KILGNLDFLITGLNGDP--W------HKIPALDPEKLNVFRTVREITGYLNIQSWPPHMH
ErbB2_Mmus KIFGSLAFLPESFDGNP--S------SGVAPLKPEHLQVFETLEEITGYLYISAWPESFQ
EGFR_Mmus AISGDLHILPVAFKGDS--F------TRTPPLDPRELEILKTVKEITGFLLIQAWPDNWT
let-23_Cele QIDGHLIIE-H-------------------AFTYEQLKVLETVKIVSEYITIV--QQNFY
ErbB4_Hsap KINGNLIFLVTGIHGDP--Y------NAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMT
ErbB3_Hsap KILGNLDFLITGLNGDP--W------HKIPALDPEKLNVFRTVREITGYLNIQSWPPHMH
ErbB2_Hsap KIFGSLAFLPESFDGDP--A------SNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP
EGFR_Hsap SISGDLHILPVAFRGDS--F------THTPPLDPQELDILKTVKEITGFLLIQAWPENRT
EGFR_Spur QINGNLIITSHTFTGDA--F------AGTTPIDPSALEIFRTVKQITGYLSVQGLHQHFT
AqueK263_Aque VITTELRISSVPPNVKLVLHIAKILWQKL--SSPSILNDLNDIREICGSLDISGFNK--E
AqueK264_Aque VITTELRISSVPPNVKLVLYIAKILWQNL--SSLSILNDLNGIREIRGSLDISGFNK--N
AqueK265_Aque IITTELRISSVPPNL-----------------DPSILNDLNEIREIRGSLDISGFNK--E
AqueK266_Aque VITTDLRILSVPVN-----------------VNLSILNDLKDIREIRGSLDISGFNK--E
* : : *. : :. : : :
Egfr_Dmel NLSYFRNLETIHGRQLMES-----------MFAAL-AIVKSSLYSLEMRNLKQISSGSVV
ErbB4_Mmus DFSVFSNLVTIGGRVLYSG------------LSLL-ILKQQGITSLQFQSLKEISAGNIY
ErbB3_Mmus NFSVFSNLTTIGGRSLYNR------------GFSLLIMKNLNVTSLGFRSLKEISAGRVY
ErbB2_Mmus DLSVFQNLRVIRGRILHDG------------AYSL-TLQGLGIHSLGLRSLRELGSGLAL
EGFR_Mmus DLHAFENLEIIRGRTKQHG------------QFSL-AVVGLNITSLGLRSLKEISDGDVI
let-23_Cele DLKFLKNLQIIEGRKLHNV------------RWALAIYQCDDLEELSLNSLKLIKTGAVL
ErbB4_Hsap DFSVFSNLVTIGGRVLYSG------------LSLL-ILKQQGITSLQFQSLKEISAGNIY
ErbB3_Hsap NFSVFSNLTTIGGRSLYNR------------GFSLLIMKNLNVTSLGFRSLKEISAGRIY
ErbB2_Hsap DLSVFQNLQVIRGRILHNG------------AYSL-TLQGLGISWLGLRSLRELGSGLAL
EGFR_Hsap DLHAFENLEIIRGRTKQHG------------QFSL-AVVSLNITSLGLRSLKEISDGDVI
EGFR_Spur NLSMFSNLERIDGRNLYGE----------PPFASLAILDNQHLEALSLISLNELKLGGAY
AqueK263_Aque TFPYLSSLKTVGNDST-QVLSQSCNGSSDSTKFSV-IIANTDLVSIDLSSLETVINGGIQ
AqueK264_Aque TFPYLSNLKTVGNDST-QVLSQSCNGSSDSTKFSV-IIADTDLISIDLSSLETVINGGIR
AqueK265_Aque TFPYLYNLKTVGNNDSNQVLSQSCNGSSDSFKYSI-IIADTELVSIDLSSLEAVINGGVR
AqueK266_Aque TFPYLSNLKTVGNDSS-QVLSQSCNGSSDSIQFSI-IIANTDLVSIDLSSLEAVINGGIQ
: : .* : . : : : : .*. : *
Egfr_Dmel IQHNRDLCYVSNIRWPAIQKEP----EQKVWVNENLRADLCEKNGTICSDQCNE--DGCW
ErbB4_Mmus ITDNSNLCYYHTINWTTLFSTI----NQRIVIRDNRRAENCTAEGMVCNHLCSN--DGCW
ErbB3_Mmus ISANQQLCYHHSLNWTRLLRGPA---EERLDIKYNRPLGECVAEGKVCDPLCSS--GGCW
ErbB2_Mmus IHRNTHLCFVNTVPWDQLFRNP----HQALLHSGNRPEEACGLEGLVCNSLCAR--GHCW
EGFR_Mmus ISGNRNLCYANTINWKKLFGTP----NQKTKIMNNRAEKDCKAVNHVCNPLCSS--EGCW
let-23_Cele IMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNK--RGCW
ErbB4_Hsap ITDNSNLCYYHTINWTTLFSTI----NQRIVIRDNRKAENCTAEGMVCNHLCSS--DGCW
ErbB3_Hsap ISANRQLCYHHSLNWTKVLRGPT---EERLDIKHNRPRRDCVAEGKVCDPLCSS--GGCW
ErbB2_Hsap IHHNTHLCFVHTVPWDQLFRNP----HQALLHTANRPEDECVGEGLACHQLCAR--GHCW
EGFR_Hsap ISGNKNLCYANTINWKKLFGTS----GQKTKIISNRGENSCKATGQVCHALCSP--EGCW
EGFR_Spur VQNNRLLCYSEETAFDAVIN-PE----YSVSFVNNKDRATCIAENKTCDPQCAD--IGCW
AqueK263_Aque LENNPSLCYLGNLSYYLANASS----SSCVLDNHRSSINECVKMKMTCHPQCSSASGWCW
AqueK264_Aque LQNNPSLCYLGNLSYYLANASS----SSCVLDNHRRRIDECVEMSMTCHPQCSSASGWCW
AqueK265_Aque LQNNPSLCYLGDLRYYLTNSSA----TSCILDDHRQSIEECVETNMTCHPQCSSASGWCW
AqueK266_Aque LENNPSLCYLGNLSYYLANASS----SSCVLDNHKRSIDECVEMNMTCHSQCSSASGWCW
: * **: : . * * * **
Egfr_Dmel GAGTDQCLTCKNFNFNGTCIADCGYISNAY-KF-D----NRTCKICHPECR---------
ErbB4_Mmus GPGPDQCLSCRRFSRGKICIESCNLYDGEFREFEN----GSICVECDSQCEK--------
ErbB3_Mmus GPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVH----EAHCFSCHPECQP--------
ErbB2_Mmus GPGPTQCVNCSQFLRGQECVEECRVWKGLPREYVR----GKHCLPCHPECQP--------
EGFR_Mmus GPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVE----NSECIQCHPECLP--------
let-23_Cele GKEPEDCLECKTWKSVGTCVEKCDT-KGFLRN-QT----SMKCERCSPECE---------
ErbB4_Hsap GPGPDQCLSCRRFSRGRICIESCNLYDGEFREFEN----GSICVECDPQCEK--------
ErbB3_Hsap GPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAH----EAECFSCHPECQP--------
ErbB2_Hsap GPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVN----ARHCLPCHPECQP--------
EGFR_Hsap GPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVE----NSECIQCHPECLP--------
EGFR_Spur GPGPRQCAKCKNAIIGDTCIEACDLDNGQYVETEASASEAAVCEHCDTQCSAGCSGPEPD
AqueK263_Aque GPNDTQCVTCTNFIFNKQCVPDCHDFDTHRVxxx--------------------------
AqueK264_Aque GPNDTQCVTCTNFIFNGQCVPDCHDFDTYGIHLFNH-NANNTCLPCHSFCN---------
AqueK265_Aque GPNDTQCVTCTNFIFNGQCVPTCNDFDAHGVHLYGH-NANNTCLACHSFCS---------
AqueK266_Aque GPNDTQCVTCTNFSFNGQCVPDCHNFDAHGIKNV--------------------------
* :* * *: * .
Egfr_Dmel ------------------------------------------------------------
ErbB4_Mmus ------------------------------------------------------------
ErbB3_Mmus ------------------------------------------------------------
ErbB2_Mmus ------------------------------------------------------------
EGFR_Mmus ------------------------------------------------------------
let-23_Cele ------------------------------------------------------------
ErbB4_Hsap ------------------------------------------------------------
ErbB3_Hsap ------------------------------------------------------------
ErbB2_Hsap ------------------------------------------------------------
EGFR_Hsap ------------------------------------------------------------
EGFR_Spur QCDCQSDSTGTNCRRMCRNVQDGPFCRAECPEPKFANAQKNCTDCHSNCLKGCNGPENNL
AqueK263_Aque ------------------------------------------------------------
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque ------------------------------------------------------------
AqueK266_Aque ------------------------------------------------------------
Egfr_Dmel ------------------------------------------------------------
ErbB4_Mmus -------------------------------------------------------MEDGL
ErbB3_Mmus -------------------------------------------------------ME-GT
ErbB2_Mmus -------------------------------------------------------QN-SS
EGFR_Mmus -------------------------------------------------------QA-MN
let-23_Cele ------------------------------------------------------------
ErbB4_Hsap -------------------------------------------------------MEDGL
ErbB3_Hsap -------------------------------------------------------ME-GT
ErbB2_Hsap -------------------------------------------------------QN-GS
EGFR_Hsap -------------------------------------------------------QA-MN
EGFR_Spur GEDGCLECPQVMLDYNRKVMECMLINTPCSDDYFYDRISHSEKSDPLAGSVICQQCDPMC
AqueK263_Aque ------------------------------------------------------------
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque ------------------------------------------------------------
AqueK266_Aque ------------------------------------------------------------
Egfr_Dmel -TCNGAGAD---------------HC-------QE-CVH---------------------
ErbB4_Mmus LTCHGPGPD---------------NC-------TK-CSH---------------------
ErbB3_Mmus STCNGSGSD---------------AC-------AR-CAH---------------------
ErbB2_Mmus ETCYGSEAD---------------QC-------EA-CAH---------------------
EGFR_Mmus ITCTGRGPD---------------NC-------IQ-CAH---------------------
let-23_Cele -TCNGLGEL---------------DC-------LT-CRHKTLYN----------------
ErbB4_Hsap LTCHGPGPD---------------NC-------TK-CSH---------------------
ErbB3_Hsap ATCNGSGSD---------------TC-------AQ-CAH---------------------
ErbB2_Hsap VTCFGPEAD---------------QC-------VA-CAH---------------------
EGFR_Hsap ITCTGRGPD---------------NC-------IQ-CAH---------------------
EGFR_Spur IGCDGAGPR---------------RC-------KQ-CKL---------------------
AqueK263_Aque -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxxxxxx
AqueK264_Aque GSCVGEGPA---------------NC-------SS-CNTYFFVN----------------
AqueK265_Aque GSCVGEGPA---------------NC-------SSSCNTNFFVN----------------
AqueK266_Aque -----QGPA---------------NC-------SI-CNTDFFVN----------------
Egfr_Dmel ------------------------------------------------------------
ErbB4_Mmus ------------------------------------------------------------
ErbB3_Mmus ------------------------------------------------------------
ErbB2_Mmus ------------------------------------------------------------
EGFR_Mmus ------------------------------------------------------------
let-23_Cele ------------------------------------------------------------
ErbB4_Hsap ------------------------------------------------------------
ErbB3_Hsap ------------------------------------------------------------
ErbB2_Hsap ------------------------------------------------------------
EGFR_Hsap ------------------------------------------------------------
EGFR_Spur ------------------------------------------------------------
AqueK263_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque ------------------------------------------------------------
AqueK266_Aque ------------------------------------------------------------
Egfr_Dmel --------------------------------------VRDGQHCVSEC----PKNKYND
ErbB4_Mmus --------------------------------------FKDGPNCVEKC----PDGLQGA
ErbB3_Mmus --------------------------------------FRDGPHCVNSC----PHGILGA
ErbB2_Mmus --------------------------------------YKDSSSCVARC----PSGVKPD
EGFR_Mmus --------------------------------------YIDGPHCVKTC----PAGIMGE
let-23_Cele -----------------------------------SD-FGNRMECVHDC----PVS----
ErbB4_Hsap --------------------------------------FKDGPNCVEKC----PDGLQGA
ErbB3_Hsap --------------------------------------FRDGPHCVSSC----PHGVLGA
ErbB2_Hsap --------------------------------------YKDPPFCVARC----PSGVKPD
EGFR_Hsap --------------------------------------YIDGPHCVKTC----PAGVMGE
EGFR_Spur --------------------------------------FRQDDECVDEC----RSGF---
AqueK263_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
AqueK264_Aque -----------------------------------VS-IGVGKLCLESC----VGDTYLP
AqueK265_Aque -----------------------------------VS-VGVGIQCLESC----VGDTYLP
AqueK266_Aque -----------------------------------VS-IGVGIECLESC----VGDTYLP
Egfr_Dmel R----GVCRECHATC---DGCTGPKDTIG-IGACTTCNLAIINNDATVKRCLLKDDKCPD
ErbB4_Mmus N----S------------------------------------------------------
ErbB3_Mmus K----G------------------------------------------------------
ErbB2_Mmus L----S-----------------------------------------------------Y
EGFR_Mmus N----N------------------------------------------------------
let-23_Cele ------------------------------------------------------------
ErbB4_Hsap N----S------------------------------------------------------
ErbB3_Hsap K----G------------------------------------------------------
ErbB2_Hsap L----S-----------------------------------------------------Y
EGFR_Hsap N----N------------------------------------------------------
EGFR_Spur ------------------------------------------------------------
AqueK263_Aque xxx---------------------------------------------------------
AqueK264_Aque DDCTSGECLPCFDGCTLSNGCAGPGKTFNNSNGCIACDTILLDRNGEQIECQ-RDVTCPS
AqueK265_Aque DSRTSGECLPCFSGCSLGYGCAGPGKTFNDSNGCMACDTILLDRNGDQIECQ-RDVTCPS
AqueK266_Aque DDR---------------------------------------------------------
Egfr_Dmel GYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETEC
ErbB4_Mmus -FIF--------------------------------------------------------
ErbB3_Mmus -PIY--------------------------------------------------------
ErbB2_Mmus MPIW--------------------------------------------------------
EGFR_Mmus TLVW--------------------------------------------------------
let-23_Cele ------------------------------------------------------------
ErbB4_Hsap -FIF--------------------------------------------------------
ErbB3_Hsap -PIY--------------------------------------------------------
ErbB2_Hsap MPIW--------------------------------------------------------
EGFR_Hsap TLVW--------------------------------------------------------
EGFR_Spur ------------------------------------------------------------
AqueK263_Aque ------------------------------------------------------------
AqueK264_Aque GYYREILS-EDRGI----------------------------------------------
AqueK265_Aque GYYWEQLT-EDRGI----------------------------------------------
AqueK266_Aque ------------------------------------------------------------
Egfr_Dmel PADHYTDEEQRECFQCHPECN---GCTGPGADD----CKS-------------CR-----
ErbB4_Mmus ---KYAD-QDRECHPCHPNCT--QGCNGPTSHD----CIY-------------YP-----
ErbB3_Mmus ---KYPD-AQNECRPCHENCT--QGCKGPELQD----CLG-------------Q------
ErbB2_Mmus ---KYPD-EEGICQPCPINCT--HSCVDLDERG----CPA--------------------
EGFR_Mmus ---KYAD-ANNVCHLCHANCT--YGCAGPGLQG----CEV--------------------
let-23_Cele ---HFPT-QKNVCEKCHPTCYD-NGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGM
ErbB4_Hsap ---KYAD-PDRECHPCHPNCT--QGCNGPTSHD----CIY-------------YP-----
ErbB3_Hsap ---KYPD-VQNECRPCHENCT--QGCKGPELQD----CLG-------------Q------
ErbB2_Hsap ---KFPD-EEGACQPCPINCT--HSCVDLDDKG----CPA--------------------
EGFR_Hsap ---KYAD-AGHVCHLCHPNCT--YGCTGPGLEG----CPT--------------------
EGFR_Spur ----YPD-VDDMCQPCHPQCR--Q-CFNGTVHD----CLD-------------CE-----
AqueK263_Aque --------xxxxxxxxxxxxxxxx--xxxxxxx----xx---------------------
AqueK264_Aque ----FFT-GTVLCHSCHELCA---TCSGPSVSD----CVL-------------CS-----
AqueK265_Aque ----FLT-DTVLCHSCHELCA---TCSGPSVSD----CVL-------------CS-----
AqueK266_Aque --------TSGECLPCFNGCTLGNGCAGPGKTF----ND---------------------
Egfr_Dmel ----------------------------------------------------NFKLFDAN
ErbB4_Mmus ----------------------------------------------------WT----GH
ErbB3_Mmus ------------------------------------------------------------
ErbB2_Mmus ------------------------------------------------------------
EGFR_Mmus ------------------------------------------------------------
let-23_Cele NNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKH-------
ErbB4_Hsap ----------------------------------------------------WT----GH
ErbB3_Hsap ------------------------------------------------------------
ErbB2_Hsap ------------------------------------------------------------
EGFR_Hsap ------------------------------------------------------------
EGFR_Spur ----------------------------------------------------SYTVQTGE
AqueK263_Aque ----------------------------------------------------xx------
AqueK264_Aque ----------------------------------------------------YIRGTNGS
AqueK265_Aque ----------------------------------------------------YIRGTNGS
AqueK266_Aque ------------------------------------------------------------
Egfr_Dmel E---T---------------GPYVNS-T--------------------------------
ErbB4_Mmus ------------------------------------------------------------
ErbB3_Mmus ------------------------------------------------------------
ErbB2_Mmus ------------------------------------------------------------
EGFR_Mmus ------------------------------------------------------------
let-23_Cele -------------VEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANG
ErbB4_Hsap ------------------------------------------------------------
ErbB3_Hsap ------------------------------------------------------------
ErbB2_Hsap ------------------------------------------------------------
EGFR_Hsap ------------------------------------------------------------
EGFR_Spur N---TFFCALSCPAEYPNELSPYVCGKTCPT--LFFPNAM-SKCEGCHTECK--DGCHNG
AqueK263_Aque ------------------------------------------------------------
AqueK264_Aque CVYMC---------------DP--------------------IRETVPM-----------
AqueK265_Aque CVFMC---------------DP--------------------IRETVPM-----------
AqueK266_Aque ------------------------------------------------------------
Egfr_Dmel -------------MFNCTS----KCPLEMRHVNYQYT-AIG---PYC----AASPP-RSS
ErbB4_Mmus ---------------------------------------------------STL--PQHA
ErbB3_Mmus ---------------------------------------------------AE---VLMS
ErbB2_Mmus -----------------------------------------------------E--QRAS
EGFR_Mmus -----------------------------------------------------W--PSGP
let-23_Cele QSTGCQKCKNFTVFKGDIAQCVSECPKNLPFSNPA----NGECLDYD-----IA--SRQR
ErbB4_Hsap ---------------------------------------------------STL--PQHA
ErbB3_Hsap ---------------------------------------------------TL---VLIG
ErbB2_Hsap -----------------------------------------------------E--QRAS
EGFR_Hsap ---------------------------------------------------------NGP
EGFR_Spur TRSGCYACKNVVVNLECRA----ECPAAYKNTNGTCLYIHG---PDQ----KATPKPGGG
AqueK263_Aque -----------------------------------------------xxxxxxx--xx-x
AqueK264_Aque ---------------NGSS----QCI------------------LVTGTMGTLD--PTGA
AqueK265_Aque ---------------NGSS----QCI------------------PVT--MGTID--PSSA
AqueK266_Aque -----------------------------------------------SNGCSAC--DT--
Egfr_Dmel KI-TANLDVNMIFIITGAVL---VPTICILCVVTYICRQKQKAKKETVKM------TMAL
ErbB4_Mmus RT-P-----LIAAGVIGGLF---ILVIMALTFAV-YVRRKSIKKKRAL--------RRFL
ErbB3_Mmus KP-H------LVIAVTVGLT---VIFLILGGSFL-YWRGRRIQNKRAM--------RRYL
ErbB2_Mmus PV-T-----FIIATVVGVLL---FLIIVVVIGIL-IKRRRQKIRKYTM--------RRLL
EGFR_Mmus KI-P-----SIATGIVGGLL---FIVVVALGIGL-FMRRRHIVRKRTL--------RRLL
let-23_Cele KT-R----MVIIGSVLFGFA---VMFLFI--LLV-YWRCQRIGKKLKI--------AEMV
ErbB4_Hsap RT-P-----LIAAGVIGGLF---ILVIVGLTFAV-YVRRKSIKKKRAL--------RRFL
ErbB3_Hsap KT-H----LTMALTVIAGLV---VIFMMLGGTFL-YWRGRRIQNKRAM--------RRYL
ErbB2_Hsap PL-T-----SIISAVVGILL---VVVLGVVFGIL-IKRRQQKIRKYTM--------RRLL
EGFR_Hsap KI-P-----SIATGMVGALL---LLLVVALGIGL-FMRRRHIVRKRTL--------RRLL
EGFR_Spur MS------IGLLAGIVTSSL---IIFIVIIVFVI-WF-KQRIKNDMYIDIPPNIDLHDMK
AqueK263_Aque xxxx----xxxxxx-----xxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------
AqueK264_Aque IVSI----EAVIGSIFGGLTLITLTVLVILILVLFLLRKNRK--SIYI------------
AqueK265_Aque GT-T----GVVIGSALGGLLLTALVILIIVMLLVFVPRALRKKNKYNL--------NEVF
AqueK266_Aque ------------------------------------------------------------
Egfr_Dmel SGCED----------------SEPLRPSNIGANLCKLRIVKDAELR--KGGVLGMGAFGR
ErbB4_Mmus -ETEL----------------VEPLTPSGTAPNQAQLRILKETELK--RVKVLGSGAFGT
ErbB3_Mmus ERGES----------------IEPLDPSE-KANKVLARIFKETELR--KLKVLGSGVFGT
ErbB2_Mmus QETEL----------------VEPLTPSGAVPNQAQMRILKETELR--KLKVLGSGAFGT
EGFR_Mmus QEREL----------------VEPLTPSGEAPNQAHLRILKETEFK--KIKVLGSGAFGT
let-23_Cele DMPE-----------------LTPIDAS-VRPNMSRICLIPSSELQTKLDKKLGAGAFGT
ErbB4_Hsap -ETEL----------------VEPLTPSGTAPNQAQLRILKETELK--RVKVLGSGAFGT
ErbB3_Hsap ERGES----------------IEPLDPSE-KANKVLARIFKETELR--KLKVLGSGVFGT
ErbB2_Hsap QETEL----------------VEPLTPSGAMPNQAQMRILKETELR--KVKVLGSGAFGT
EGFR_Hsap QEREL----------------VEPLTPSGEAPNQALLRILKETEFK--KIKVLGSGAFGT
EGFR_Spur SCDYT----------------GAPLTPSNVEPNQAQLKIIKDTELK--LGPVLGSGAFGT
AqueK263_Aque x--------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--xxxxxxxxxxxx
AqueK264_Aque AELELCNEVCIFKTYSFISYYVNIETPxKVPPDATKLILIPETELE--FKKELGSGAFGT
AqueK265_Aque SSPEELELF---------TLGKETLQPPRMAPNATRLIVAPEDELE--FGKELGAGAFGT
AqueK266_Aque ------------------------------------------------------------
Egfr_Dmel VYKGVWVPE-GENVK-IPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMS
ErbB4_Mmus VYKGIWVPE-GETVK-IPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLS
ErbB3_Mmus VHKGIWIPE-GESIK-IPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPG
ErbB2_Mmus VYKGIWIPD-GENVK-IPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLT
EGFR_Mmus VYKGLWIPE-GEKVK-IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLT
let-23_Cele VFAGIYYPKRAKNVK-IPVAIKVFQT--DQSQTDEMLEEATNMFRLRHDNLLKIIGFCMH
ErbB4_Hsap VYKGIWVPE-GETVK-IPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLS
ErbB3_Hsap VHKGVWIPE-GESIK-IPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG
ErbB2_Hsap VYKGIWIPD-GENVK-IPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLT
EGFR_Hsap VYKGLWIPE-GEKVK-IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLT
EGFR_Spur VYKGLWIPD-GEKIR-IPVAIKALREV-SPHAAEELLEEAKVMASVDHPCLLRLLCVCIA
AqueK263_Aque xx-xxxxxx-xxxxxxxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
AqueK264_Aque VYEGYWKPD-NDEAE-YHVAIKILKN-TSADASKELLQEGVVMATx--------------
AqueK265_Aque VYEGYWKPA-NDENE-YHVAIKVLKN-TSASASKELLQEGVVMATMDHENVVRLYCVCMS
AqueK266_Aque ---ILLNLN-GEQIKC------QRNV-TC-------------------------------
Egfr_Dmel S-QMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARN
ErbB4_Mmus P-TIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARN
ErbB3_Mmus S-SLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRN
ErbB2_Mmus S-TVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARN
EGFR_Mmus S-TVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARN
let-23_Cele DDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRN
ErbB4_Hsap P-TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARN
ErbB3_Hsap S-SLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARN
ErbB2_Hsap S-TVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARN
EGFR_Hsap S-TVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARN
EGFR_Spur Q-NMTLITQLMPLGAILDYVRQHKEQIGSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARN
AqueK263_Aque x-xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLVHRDLAARN
AqueK264_Aque -------------------xxxHRNSISAQTVINFSLQIAKGMAYLESKSLVHRDLAARN
AqueK265_Aque K-QLMLVSQFVPCGALIDYIKKQQDRLNAHTILLFSSQIANGMAYLETKHLVHRDLAARN
AqueK266_Aque -----------PSGYYREQ-------------------------LLED------------
Egfr_Dmel VLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGV
ErbB4_Mmus VLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGV
ErbB3_Mmus VMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGV
ErbB2_Mmus VLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGV
EGFR_Mmus VLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGV
let-23_Cele VLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGV
ErbB4_Hsap VLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGV
ErbB3_Hsap VLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGV
ErbB2_Hsap VLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGV
EGFR_Hsap VLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGV
EGFR_Spur VLVQSPAQVKITDFGLAKFLEVDSNEYKAQ----------------------------GV
AqueK263_Aque ALVQSHLKVLITDFGLTRFIEPDESHYEASGSKLPVRWLPPESIRQRIFTHKTDIWSFGV
AqueK264_Aque VLVQSHLKVLITDFGLTRFIEPDESHYEAPGSKLPVRWLPPESIQQRIFTHKTDVWSFGV
AqueK265_Aque VLVQTPVKVKITDFGLTRIIEANQSHYEATTSKMPVRWLPPESIRNRVFTHKTDVWSFGV
AqueK266_Aque ------------------------------------------------------------
Egfr_Dmel TIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFK
ErbB4_Mmus TIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFK
ErbB3_Mmus TVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFK
ErbB2_Mmus TVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFR
EGFR_Mmus TVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFR
let-23_Cele TCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFE
ErbB4_Hsap TIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFK
ErbB3_Hsap TVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFK
ErbB2_Hsap TVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFR
EGFR_Hsap TVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFR
EGFR_Spur TLWELMTFGGKPYEGVKAREVPELLERGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFK
AqueK263_Aque TVWEILTFGESPFKGKSVFELLKLLEKGDRLKQPKTCTLVFYKSLQNCWELEPEKRPSFE
AqueK264_Aque TVWEILTFGESPFKGKSVFELLKLLEKGDRLKQPKTCTLEFYKTLQNCWELEPERRPSFE
AqueK265_Aque TVWEILTFGARPYQGKKPYEILKMLEGGHRLDQPVTCTIDLYAVLLECWLLEPDSRPDFV
AqueK266_Aque -----------------------------------------RGIFLTGWELEPERRPSFE
: * : ** *
Egfr_Dmel QLTTVFAEFARDPGRYLAIPGDKFTRL-------PAYTSQDEKDLIRKLAPTTDGS---E
ErbB4_Mmus ELAAEFSRMARDPQRYLVIQGDDRMKL-------PSPN---DSKFFQNLLDEEDL----E
ErbB3_Mmus ELANEFTRMARDPPRYLVIKRASGPGIP------PAAE---PSALSTKELQDAEL----E
ErbB2_Mmus ELVSEFSRMARDPQRFVVIQNED-LGP-------SSPM---DSTFYRSLLEDDDM----G
EGFR_Mmus ELILEFSKMARDPQRYLVIQGDERMHL-------PSPT---DSNFYRALMDEEDM----E
let-23_Cele ILYERFKEFCKVPQLFLENSNK--ISES------D---LSAEERFQTERIR-----EMFD
ErbB4_Hsap ELAAEFSRMARDPQRYLVIQGDDRMKL-------PSPN---DSKFFQNLLDEEDL----E
ErbB3_Hsap ELANEFTRMARDPPRYLVIKRESGPGIA------PGPE---PHGLTNKKLEEVEL----E
ErbB2_Hsap ELVSEFSRMARDPQRFVVIQNED-LGP-------ASPL---DSTFYRSLLEDDDM----G
EGFR_Hsap ELIIEFSKMARDPQRYLVIQGDERMHL-------PSPT---DSNFYRALMDEEDM----D
EGFR_Spur QMQEELERMTKDPQRYLVIQNDGAMSL-------PSPT---PSDFYKTLMQDTESGADPD
AqueK263_Aque DLVYQFNTMMMSPKKYVKIKKTRALRGTVYTSHDGNNK---ESNFHKRRNEDTGNV----
AqueK264_Aque DLVYQFNTMMMSPKKYEDSNDKD-------------------------------------
AqueK265_Aque DLGRRFHEFMNDPARYVLTVVSM-------------------------------------
AqueK266_Aque DLVYQFNTMMMSPKKYVKIKKTRALRGAVYDSHDSNKK---ESNFHKGRLKDTHKN----
: : : * :
Egfr_Dmel AIAEPDDYLQPKAA--P---------GPSHRTD---------------------------
ErbB4_Mmus DMMDAEEYLVPQAFNIP---------PPIY-TSRTRIDSNRSEIGHSPPPAYTPMSGNQF
ErbB3_Mmus PDLDLDLDVEVEEEGLATT-LGSALSLPTG-T-LTRPR--GSQSLLSPSSGYMPMNQSNL
ErbB2_Mmus ELVDAEEYLVPQQGFFSP--------DPALGTGSTAHRRHRSSSA---------------
EGFR_Mmus DVVDADEYLIPQQGFFN---------SPS--TSRTPLLSS--------------------
let-23_Cele GNIDPQMYFDQ--GSLPS--------MP--------------------------------
ErbB4_Hsap DMMDAEEYLVPQAFNIP---------PPIY-TSRARIDSNRSEIGHSPPPAYTPMSGNQF
ErbB3_Hsap PELDLDLDLEAEEDNLATTTLGSALSLPVG-T-LNRPR--GSQSLLSPSSGYMPMNQGNL
ErbB2_Hsap DLVDAEEYLVPQQGFFCP--------DPAPGAGGMVHHRHRSSST---------------
EGFR_Hsap DVVDADEYLIPQQGFFS---------SPS--TSRTPLLSS--------------------
EGFR_Spur LLMDAEDYLQPMSLTA--------------------------------------------
AqueK263_Aque ---------D--------------------------------------------------
AqueK264_Aque ------GYVDCLQENFN---------DK---------------------DGYVD------
AqueK265_Aque ------SVC---------------------------------------------------
AqueK266_Aque -SNDKDGYVDCLHEDSN---------DK---------------------DGYVD------
Egfr_Dmel ------------------------------------------------------------
ErbB4_Mmus VYQ------DGGFA---TQQ-GMPMPYRATTSTIPEAPVAQGATAEMFDDSCCNGTLRKP
ErbB3_Mmus GEACLDSAVLGGREQFSRPISLHPIPRGRQTSESSEGHV-TGSEAELQERVSMCRSRSRS
ErbB2_Mmus --R------SGGGE---LTL-GLE-PSEEEPPRSPLAP-SEGAGSDVFDGDLAVGVTKGL
EGFR_Mmus ----------------------------------------LSATSN--NSTVACINRN--
let-23_Cele -----------------------------------SSP-TSMATFTIPHGDLMNR-----
ErbB4_Hsap VYR------DGGFA---AEQ-GVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKP
ErbB3_Hsap GESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHV-TGSEAELQEKVSMCRSRSRS
ErbB2_Hsap --R------SGGGD---LTL-GLE-PSEEEAPRSPLAP-SEGAGSDVFDGDLGMGAAKGL
EGFR_Hsap ----------------------------------------LSATSN--NSTVACIDRNGL
EGFR_Spur ---------------------------------------------N--NMTY--------
AqueK263_Aque ---------------------------------------CLHEDS--NDK-------DGY
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque ------------------------------------------------------------
AqueK266_Aque ---------------------------------------CLHEDS--NDK-------DGY
Egfr_Dmel ---CTDEIPK--LNRYCKD-PSNKNSSTGDDETDSSAREVGVGNLRLDLPVDEDDYLMPT
ErbB4_Mmus VAPHVQEDSS--TQRYSAD-PTVFAPERNP-----------------RGELDEEGYMTPM
ErbB3_Mmus RSPRPRGDSAYHSQRHSLLTPVTPLSPP-G-----------------LEEEDGNGYVMPD
ErbB2_Mmus QSLSPHDLSP--LQRYSED-PTLPLP------------------------PETDGYVAPL
EGFR_Mmus GSCRVKEDAF--LQRYSSD-PTGAVTEDN----------------------IDDAF----
let-23_Cele -----MQSVN--SSRYKTE-PFDYGST----------------------AQEDNSYLIPK
ErbB4_Hsap VAPHVQEDSS--TQRYSAD-PTVFAPERSP-----------------RGELDEEGYMTPM
ErbB3_Hsap RSPRPRGDSAYHSQRHSLLTPVTPLSPP-G-----------------LEEEDVNGYVMPD
ErbB2_Hsap QSLPTHDPSP--LQRYSED-PTVPLP------------------------SETDGYVAPL
EGFR_Hsap QSCPIKEDSF--LQRYSSD-PTGALTEDS----------------------IDDTF----
EGFR_Spur --------------------------------------------------ESQQGFF---
AqueK263_Aque V-DCLQEDS--------N---------------------------------DKDGYVD--
AqueK264_Aque --------------------------CLQ------------------EDFNDKDGYVDCL
AqueK265_Aque ------------------------------------------------------------
AqueK266_Aque V-DCLHEDS--------ND-KDGYVDCLH------------------EDSNDKDGYVECL
Egfr_Dmel C---------------------------Q--PGPN-------------------------
ErbB4_Mmus H--------------------------DK--PKQEYLNPVEEN-PFVSRRKNGDLQA---
ErbB3_Mmus THLRGTSSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRKRRGSPARPPRP-GSLEELGY
ErbB2_Mmus A--------------------------CS--PQPEYVNQPEVR-PQSPLTPEGPPPP---
EGFR_Mmus ----------------------------L--PVPEYVNQS------VPKRPAGSV-----
let-23_Cele TKEV-------------QQSAVLYTAVTNEDGQTE--------------------LS---
ErbB4_Hsap R--------------------------DK--PKQEYLNPVEEN-PFVSRRKNGDLQA---
ErbB3_Hsap THLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRP-SSLEELGY
ErbB2_Hsap T--------------------------CS--PQPEYVNQPDVR-PQPPSPREGPLPA---
EGFR_Hsap ----------------------------L--PVPEYINQS------VPKRPAGSV-----
EGFR_Spur ------------------------------------------------------------
AqueK263_Aque --------------------------------------CLHED-----------------
AqueK264_Aque Q--------------------------ED--SNDGYV-----------------------
AqueK265_Aque ------------------------------------------------------------
AqueK266_Aque H--------------------------EDSNDKDSYIDCLHED-----------------
Egfr_Dmel -------------------------------------NNNNINNPNQNNM------AAV-
ErbB4_Mmus ---------------LDNP--EYHSASSGP----PKAEDEYVN-----------------
ErbB3_Mmus EYMDVGSDLSASLGSTQSC--PLHPMAIVPSAGTTPDEDYEYMNRRRGAGGSGGDYAAMG
ErbB2_Mmus ---------------I-RPAGATLERPKTL----SPGKNGVVK-----------------
EGFR_Mmus ----------------QNP--VYHNQPLHP----APGRDLHYQ-----------------
let-23_Cele ---------------PSNG--DYYNQPNTP----S-SSSGYYNEPHLKT-----------
ErbB4_Hsap ---------------LDNP--EYHNASNGP----PKAEDEYVN-----------------
ErbB3_Hsap EYMDVGSDLSASLGSTQSC--PLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMG
ErbB2_Hsap ---------------A-RPAGATLERPKTL----SPGKNGVVK-----------------
EGFR_Hsap ----------------QNP--VYHNQPLNP----APSRDPHYQ-----------------
EGFR_Spur ------------------------------------------------------------
AqueK263_Aque ------------------------------------------------S-----------
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque ------------------------------------------------------------
AqueK266_Aque ------------------------------------------------A-----------
Egfr_Dmel ---GVAAGYMDL---IGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGVPGTMEVK
ErbB4_Mmus ----------EPLYLNTFANALGSAEYMKNS-------VL--------------------
ErbB3_Mmus ACPAAEQGYEEMRAFQGPGHQAPHVRYARLK-------TL--------------------
ErbB2_Mmus ----------DV---FAFGGAVENPEYLAPRAGT--ASQP--------------------
EGFR_Mmus ---------------NPHSNAVGNPEYLNT------------------------------
let-23_Cele ------------------------------------------------------------
ErbB4_Hsap ----------EPLYLNTFANTLGKAEYLKNN-------IL--------------------
ErbB3_Hsap ACPASEQGYEEMRAFQGPGHQAPHVHYARLK-------TL--------------------
ErbB2_Hsap ----------DV---FAFGGAVENPEYLTPQGGA--APQP--------------------
EGFR_Hsap ---------------DPHSTAVGNPEYLNT------------------------------
EGFR_Spur ------------------------------------------------------------
AqueK263_Aque ---------------------DDNDGYVDCLQ----------------------------
AqueK264_Aque ------------------------------------------------------------
AqueK265_Aque ------------------------------------------------------------
AqueK266_Aque ---------------------NDKDGYIDCLQ----------------------------
Egfr_Dmel VPMPGSEPTSSDHEYYNDTQR------------E------LQP-----------------
ErbB4_Mmus SVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIR-P-IVAENPEYL
ErbB3_Mmus RSLEATDSAFDNPDYWHSRLFP--------------------------------------
ErbB2_Mmus HPSPAFSPAFDNLYYWDQNSSEQ-----------------GPPPSTFE-GTPTAENPEYL
EGFR_Mmus AQPTCLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKE-TKPNGIFK-G-PTAENAEYL
let-23_Cele ----------------------------------------KKPETSEEAEAVQYENEE--
ErbB4_Hsap SMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIR-P-IVAENPEYL
ErbB3_Hsap RSLEATDSAFDNPDYWHSRLFP--------------------------------------
ErbB2_Hsap HPPPAFSPAFDNLYYWDQDPPER-----------------GAPPSTFK-GTPTAENPEYL
EGFR_Hsap VQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKE-AKPNGIFK-G-STAENAEYL
EGFR_Spur ------------------------------------------------------------
AqueK263_Aque ------------------EDS----ND-KDGYVDCFD----------E-GANDA------
AqueK264_Aque ---------------------------------DCFN----------E-GPNDA------
AqueK265_Aque ------------------------------------------------------------
AqueK266_Aque ------------------EDS-------NDGDIDCFN----------E-GANDA------
Egfr_Dmel -L-----------HRNRNTETRV
ErbB4_Mmus SEFSLKPGTMLPPPPYRHRNTVV
ErbB3_Mmus ----------------KANAQRI
ErbB2_Mmus -----------------GLDVPV
EGFR_Mmus RV-----------APPSSEFIGA
let-23_Cele ---------------VSQKETCL
ErbB4_Hsap SEFSLKPGTVLPPPPYRHRNTVV
ErbB3_Hsap ----------------KANAQRT
ErbB2_Hsap -----------------GLDVPV
EGFR_Hsap RV-----------APQSSEFIGA
EGFR_Spur -------------PVVSHYWIGR
AqueK263_Aque -V-----------IMKTLATSIA
AqueK264_Aque -I-----------VTKTLATSIA
AqueK265_Aque -V-----------CVGVCELYHV
AqueK266_Aque -V-----------IMKTLATSIV