Protein (view, download) , Domain (view, download)
PRKY_Hsap        MEAPGPA------------------------------QA---------------------
PRKX_Hsap        MEAPGLA------------------------------QA---------------------
PKACg_Hsap       MGNAPAK------------------------------KDT-----------E--------
PKACb_Hsap       MAAYREP------------------------------PCN-----------QYTGTT-T-
PKACa_Hsap       MGNAAAA------------------------------KKG-----------S--------
Pka-C1_Dmel      MGNNATT------------------------------SNK-----------K--------
Pka-C2_Dmel      MSQHTSQ------------------------------YVF--------------------
CG12069_Dmel     MGPQPEQ------------------------------AQM-----------HF-------
PKA-C3_Dmel      MSTATCA------------------------------RFCTPL---SS---G-T------
PRKX_Mmus        MEPPAGA------------------------------AA---------------------
PKACb_Mmus       MAAHKEL------------------------------SSG-----------QHSGTP-T-
PKACa_Mmus       MGNAAAA------------------------------KKG-----------S--------
kin-1_Cele       MLKFLKP------------------------------KSS-----------DEG------
F47F2.1_Cele     MVILSHH------------------------------KRS-----------PP-L-LMRL
TPK1_Scer        MSTEEQN------------------------------GGG-----------QKSL-----
TPK2_Scer        MEFVAER------------------------------AQP-----------VGQT-----
TPK3_Scer        MYVDPMN------------------------------NNE-----------IRKL-----
DDB0185224_Ddis  MSAILNN------------------------------YQY-----------IPNN-SL--
pk4_Ddis         QQQQQQQ------------------------------QQQ-----------QQQQ-QQ--
PKA_Ddis         MSNSNNN------------------------------SSS-----------G-N------
17649_Tthe       MQISEEQ------------------------------FF------------E-QF-----
18333_Tthe       MNWEELV------------------------------YKLSYLKIERDNQIE-NL-----
2171_Tthe        MEGFKAK------------------------------QVK-----------LTEFDVMNT
26485_Tthe       MEKAKKM--------------------------------K--------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  MSFQHHP------------------------------TSL-----------SMPA-----
CC1G_04466_Ccin  MIKRMAG------------------------------KLT-----------AHIGGHHNG
CC1G_01089_Ccin  MGPVRAN------------------------------KST-----------REAR-----
AqueK013_Aque    MALFFPCDVDCEDVFCDCLFKRTEPAHIVRYELQPRPAAT---------TVSHSETQ-P-
AqueK014_Aque    MGGHLRK------------------------------DQS-----------KAK-KP-P-
AqueK015_Aque    MTDLTHE------------------------------EEE-----------E--------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       MEDIQVE-----------------------------------------------------
GK006_Glam       MGQNQSG------------------------------VAG-----------NA-------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       --------------ALQK----------------LE------------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      --------------------A----------------------GSTSKLTTGNGSGNTMT
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       --------------ALQK----------------LE------------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     ----F---RICRFF----------------------------------------------
TPK1_Scer        ------------------------------------------------------------
TPK2_Scer        ------------------------------------------------------------
TPK3_Scer        ------------------------------------------------------------
DDB0185224_Ddis  ------------------------------------------------------------
pk4_Ddis         ------------------------------------------------------------
PKA_Ddis         --------------------HNSTTIN----NPKVNVYSNIPNS--TTYTYGSGGGGTLS
17649_Tthe       ------------------------------------------------------------
18333_Tthe       -------------SLNQKIAENQTKIKNDIFQDSINPFNY--------------------
2171_Tthe        ---LGTVCQIVLFN----------------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ------------------------------------------------------------
CC1G_04466_Ccin  KGFLG-------------------------------------------------------
CC1G_01089_Ccin  ------------------------------------------------------------
AqueK013_Aque    -------------LSVPR------------------------------------------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    ------------------------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------------AA---------------A
PRKX_Hsap        ------------------------------------------AA---------------A
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       -------------------------------------------------G----------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      SAYKIPSNN---------ST----------------------TA---------------N
PRKX_Mmus        ------------------------------------------TV---------------K
PKACb_Mmus       -------------------------------------------------G----------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     --------R---------RLM--SS---------------STSS---------------V
TPK1_Scer        ------------------------D---------------DRQG---------------E
TPK2_Scer        ------------------------I---------------QQQN---------------V
TPK3_Scer        ------------------------S---------------ITAK---------------T
DDB0185224_Ddis  ------------------------N---------------S-NN---------------S
pk4_Ddis         ------------------------QH--------------Q-KT---------------S
PKA_Ddis         GN--NTNNNNTNNNNNNNNN----------------------SS---------------G
17649_Tthe       ------------------------------------------------------------
18333_Tthe       ---IVPFEK---------ES----------------------SS---------------S
2171_Tthe        --------L----------NL--SD---------------VQSS-DRYIPFRIGTAFVQK
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ------------------------EPVRRISITYQQPSCPESQVVV-------------T
CC1G_04466_Ccin  --------------------ATGLT---------------PSSP---------------S
CC1G_01089_Ccin  ------------------------------------------NH---------------V
AqueK013_Aque    -------------------------------------------------P----------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    ------------------------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        E-----------------------------------------------------------
PRKX_Hsap        E-----------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       -------------------------------FASRLF-----------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      D---------------SS---NTETTFTF-------------------------------
PRKX_Mmus        D-----------------------------------------------------------
PKACb_Mmus       -------------------------------FASRLF-----------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     E------------SV--E---D--------------------------------------
TPK1_Scer        E------------SQ--K---GETS-E---------------------------------
TPK2_Scer        N------------T---------YG-QGVLQ------P----------------------
TPK3_Scer        E------------TT--P---DNVG-QDIPV------N----------------------
DDB0185224_Ddis  N------------------NGNNSTILSLCDNATQL------------------------
pk4_Ddis         PSTSFVDYNNINNSNGNNINGTTSTCN---------------------------------
PKA_Ddis         D---------------NK---NHSPVTSATD------RLTKMDIEEKWDNKNYEKDEREK
17649_Tthe       ------------------------QIKLI--------QL---------------------
18333_Tthe       E-----------------------NIDFL--------DA---------------------
2171_Tthe        A------------SFYIK---N--------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  E--APITPPLSPKSI--ATKSGAMPVEEMPICSSKPIQI---------------------
CC1G_04466_Ccin  E------------AM-YP---DTTTLPTIPM------AV---------------------
CC1G_01089_Ccin  E-----------------------------------------------------------
AqueK013_Aque    -------------------------------TPSRQI-----------------------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    E------------RM--Q---H--------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       -------HRH-----------------------------------------------SKG
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      -KLGRSNGRSSSNV---------------------ASS----------------------
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       -------HRH-----------------------------------------------SRG
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     ------------------------------------------------------------
TPK1_Scer        --------------------------------------------------------R---
TPK2_Scer        --------------------------------------------------------H---
TPK3_Scer        --------------------------------------------------------A---
DDB0185224_Ddis  --------------------------------------------------------M---
pk4_Ddis         ------------------------------------------------------------
PKA_Ddis         SP---LFHILASNLNSFGNFKVPSTFSLTPPEPNKQQQPQQQPQQQQPQQQQPQQQQ---
17649_Tthe       -----------------------------------AKI----------------KQR---
18333_Tthe       -----------------------------------QQN----------------EQD---
2171_Tthe        ------------------------------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  --------------------------------------------------------HSEQ
CC1G_04466_Ccin  -----------------------------------SSL----------------EHR---
CC1G_01089_Ccin  ------------------------------------------------------------
AqueK013_Aque    -------QQD-----------------------------------------------DNN
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    ------------------------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        -----------------------------S------------------------------
PRKX_Hsap        -----------------------------S------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       T-----------AHDQ-------------K-------TAL----E---------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      -----------------------------E------------------------------
PRKX_Mmus        -----------------------------P------------------------------
PKACb_Mmus       T-----------AQEH-------------R-------AAL----E---------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       -------------------------------------SSK----D---------------
F47F2.1_Cele     --------------E--------------S-------CSN----E--CSA----------
TPK1_Scer        --------------E--------------T-------TAT----E--SGN----------
TPK2_Scer        --------------H---------------------------------------------
TPK3_Scer        --------------H--------------S-------VHE----E--C-S----------
DDB0185224_Ddis  --------------DIIMREFNEPIFDYNQ-------NSS----EINK------------
pk4_Ddis         -----------------------------S-------TSS----S-KS------------
PKA_Ddis         -----------------------------P-------------------QQQQ-------
17649_Tthe       -----------------------------E-------------------EQQ--------
18333_Tthe       -----------------------------S-------------------DEDDYQYDEDE
2171_Tthe        --------------K--------------E-------IYS--------AS----------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  --------------E--------------A-------MDV----E--SAP----------
CC1G_04466_Ccin  --------------D--------------S-------IST----E--RTS----------
CC1G_01089_Ccin  -----------------------------AGPTQRSPP----------------------
AqueK013_Aque    NNNDNNEDCSRTSHES-------------R-------QNIDRFDE---------------
AqueK014_Aque    -------------LN--------------S-------SAM----G---------------
AqueK015_Aque    --------------Q--------------T-------VLP-------AQT----------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------N-SR---------E----------
PRKX_Hsap        ------------------------------------D-SR---------K----------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       -N------------------DS--LHFSE-------------------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      ------------------------------------S-SD---------P----------
PRKX_Mmus        ------------------------------------D-HD---------P----------
PKACb_Mmus       -D------------------DG--LRASE-------------------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     --------------------------------------SF---------T----------
TPK1_Scer        ------------------------------------E-SK---------S----------
TPK2_Scer        -------------------------------------------------D----------
TPK3_Scer        ------------------------------------S-NT---------P----------
DDB0185224_Ddis  ------------------------------------SLVK---------TIKS-------
pk4_Ddis         ------------------------------------NSKE---------IYNENNNNNNN
PKA_Ddis         ---QQQPQQQQQPQ--------QQLQQNNQQQQQQLQ-QQ---------Q----------
17649_Tthe       ---NRNGD------------------------I--QQ-SE---------P----------
18333_Tthe       EDEDDNGEENEQYFNQIKMNENAILN-NNQNAQ--NQ-KMNKIQFQCFED----------
2171_Tthe        --------------------------------------SY---------L----------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ------------------------------------V-HQ---------H----------
CC1G_04466_Ccin  ---------------------------------------T--------------------
CC1G_01089_Ccin  --------------------------------------QA---------PY---------
AqueK013_Aque    -D----------LSLALYLSSQ--VETNS-------------------------------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    --------------------------------------ST---------T----------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       ------------------------------------------------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      ------------------------------------------------------------
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       ------------------------------------------------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     --------------------------FD--------------------------------
TPK1_Scer        --------------------------VE--------------------------------
TPK2_Scer        --------------------------LQ--------------------------------
TPK3_Scer        --------------------------VE--------------------------------
DDB0185224_Ddis  -------------------------LLETLTKNLNNINNNIN-----------------N
pk4_Ddis         NNNNSFTNVHNNNNNNNNNRKRRNSHISYDTPDSNNIDNNIESNDTESGFRKNSKKSTDN
PKA_Ddis         ------------------------------------------------------------
17649_Tthe       ------------------------------------------------------------
18333_Tthe       ------------------------------------------------------------
2171_Tthe        --------------------------ID--------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  --------------------------PN--------------------------------
CC1G_04466_Ccin  ------------------------------------------------------------
CC1G_01089_Ccin  ------------------------------------------------------------
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    --------------------------TD--------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       -------------H----------------------------------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      ------------------------------------------------------------
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       -------------H----------------------------------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     ---------TN---N---------------------------------------------
TPK1_Scer        ---------KE-GGE---------------------------------------------
TPK2_Scer        ---------QR---Q---------------------------------------------
TPK3_Scer        ---------IN-GRN---------------------------------------------
DDB0185224_Ddis  NISNNNNNNNN----NNNNN-NNNNNNNN---------------NINNNNNFNTPQIIIN
pk4_Ddis         ----NNNNNNNNNNNNNNNNNNNNNNNNNNSCNINGNINNGNSNNINNNNCSNID-----
PKA_Ddis         ------------------------------------------------------------
17649_Tthe       ------------------------------------------------------------
18333_Tthe       ------------------------------------------------------------
2171_Tthe        ---------SL---Y---------------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ---------TMPGEQ---------------------------------------------
CC1G_04466_Ccin  --------------S---------------------------------------------
CC1G_01089_Ccin  ------------------------------------------------------------
AqueK013_Aque    -------------N----------------------------------------------
AqueK014_Aque    -------------N----------------------------------------------
AqueK015_Aque    ---------SV---A---------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       ------------------------------------------------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      ------------------------------------------------------------
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       ------------------------------------------------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     ------------------------------------------------------------
TPK1_Scer        ------------------------------------------------------------
TPK2_Scer        ------------------------------------------------------------
TPK3_Scer        ------------------------------------------------------------
DDB0185224_Ddis  DNYKLYTPPPAPMLKGLSCEVPFETMEYMQPLDLSNNNISLNNSCNMI------------
pk4_Ddis         --------------------------------------------STLADVSKHQYTNQHQ
PKA_Ddis         ------------------------------------------------------------
17649_Tthe       ------------------------------------------------------------
18333_Tthe       ------------------------------------------------------------
2171_Tthe        ------------------------------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ------------------------------------------------------------
CC1G_04466_Ccin  ------------------------------------------------------------
CC1G_01089_Ccin  ------------------------------------------------------------
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    ------------------------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        -----------------------VT---E-D-----AA---------DW-----------
PRKX_Hsap        -----------------------VA---E-E-----TP---------DG-----------
PKACg_Hsap       -----------------------QE---E-S-----VN---------E--F---------
PKACb_Hsap       ----------------T-AL---WD---R-S-----MK---------E--F---------
PKACa_Hsap       -----------------------EQ---E-S-----VK---------E--F---------
Pka-C1_Dmel      ------------------VD---AA---E-T-----VK---------E--F---------
Pka-C2_Dmel      -------------------N---SK---E-D-----YN---------V--I---------
CG12069_Dmel     -------------------S---PK---V-D-----YI---------L--I---------
PKA-C3_Dmel      -----------------------LE---S-D-----YS---------EEDP---------
PRKX_Mmus        -----------------------VK---T-K-----VS----------------------
PKACb_Mmus       ----------------T-AS---WD---K-S-----MK---------E--F---------
PKACa_Mmus       -----------------------EQ---E-S-----VK---------E--F---------
kin-1_Cele       ------------------NK---NS---A-S-----LK---------E--F---------
F47F2.1_Cele     -----------------NSR---GN---N-Q-----VN---------E--L---------
TPK1_Scer        -----------T-----QEK---PK---QPH-----VT---------YY-N---------
TPK2_Scer        -----------------QQQ---QQ---R-Q-----HQ---------Q------------
TPK3_Scer        -----------------SGK---LK---E-E-----AS---------A--G---------
DDB0185224_Ddis  NNDNNNNNNNNNNNNNNNNN---NN---N-Q-----QQ---------Q--FY--------
pk4_Ddis         QQQNIQQQQQQQQQKNQQQQ---QQ---Q-Q-----QQ---------Q--QQNNQQQQQN
PKA_Ddis         -----------------------LQ---Q-Q-----LQ---------QQQQ---------
17649_Tthe       -----------------------FVE--D-D-----LI---------SE-F---------
18333_Tthe       -----------------------FDDKEN-DYCNDLNK---------NE-F---------
2171_Tthe        -----------KARKNSASQHSYIH---N-K-----IK---------K--N---------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  -----------------QAQ---SQ---D-Q-----SN---------E--S---------
CC1G_04466_Ccin  -----------------MGD---ES---V-A-----GG---------R--F---------
CC1G_01089_Ccin  ------------------EE---KK---E-D-----GYVLVAAGKLGR--V---------
AqueK013_Aque    ------------------QN---EQ---S-N-----SN---------S--F---------
AqueK014_Aque    ----------------A-PG---KP---D-V-----VQ---------A--F---------
AqueK015_Aque    -----------------ASE---LA---R-H-----LG---------Q--V---------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       -------------------G---F----K-D-----AD----------------------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       ------------------------------------------------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      ------------------------------------------------------------
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       ------------------------------------------------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     ------------------------------------------------------------
TPK1_Scer        ------------------------------------------------------------
TPK2_Scer        ------------------------------------------------------------
TPK3_Scer        ------------------------------------------------------------
DDB0185224_Ddis  ------------------------------------NAPSSNSTPSHSSPSSPT------
pk4_Ddis         NQQQQQNNQQQQQHQQQNSQQQQNNQHQQQLQQQQYQQKHYNNNNNNNNNNQPQTSNQNI
PKA_Ddis         ------------------------------------------------------------
17649_Tthe       ------------------------------------------------------------
18333_Tthe       ------------------------------------------------------------
2171_Tthe        ------------------------------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ------------------------------------------------------------
CC1G_04466_Ccin  ------------------------------------------------------------
CC1G_01089_Ccin  ------------------------------------------------------------
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    ------------------------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       -----------------------------------L--AKA-------------------
PKACb_Hsap       -----------------------------------L--AKA-------------------
PKACa_Hsap       -----------------------------------L--AKA-------------------
Pka-C1_Dmel      -----------------------------------L--EQA-------------------
Pka-C2_Dmel      -----------------------------------L--DNM-------------------
CG12069_Dmel     -----------------------------------L--DKL-------------------
PKA-C3_Dmel      -----------------------------------EQEQQRP------------------
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       -----------------------------------L--AKA-------------------
PKACa_Mmus       -----------------------------------L--AKA-------------------
kin-1_Cele       -----------------------------------L--DKA-------------------
F47F2.1_Cele     -----------------------------------A--EET-------------------
TPK1_Scer        -----------------------------------E--EQY-------------------
TPK2_Scer        --------------------------------------LLT-------------------
TPK3_Scer        -----------------------------------I--CLV-------------------
DDB0185224_Ddis  ----------------TSSIPFH----------PNF--TLS-------------------
pk4_Ddis         QHSQGLNYNQNQNQNQNQEAPIVVNSLILRSIGMMT--SKI-------------------
PKA_Ddis         -----------------------------------QQQQQQQQQQQKQQKQQQQQQQHLH
17649_Tthe       -----------------------------------NHLIEI-------------------
18333_Tthe       -----------------------------------NKNFEK-------------------
2171_Tthe        -----------------------------------E--AEN-------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  -----------------------------------Q--NRP-------------------
CC1G_04466_Ccin  -----------------------------------G--IEA-------------------
CC1G_01089_Ccin  -----------------------------------YKSAYD-------------------
AqueK013_Aque    -----------------------------------V--SLI-------------------
AqueK014_Aque    -----------------------------------L--VEA-------------------
AqueK015_Aque    -----------------------------------S--LES-------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       ------------------------------------------------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      ------DPATNSRSSSTATTTTTSSADHDNDVDEEDEEDDENEGEGNGRDADDATHDSSE
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       ------------------------------------------------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     ------------------------------------------------------------
TPK1_Scer        ------------------------------------------------------------
TPK2_Scer        ------------------------------------------------------------
TPK3_Scer        ------------------------------------------------------------
DDB0185224_Ddis  ------------------------------------------------------------
pk4_Ddis         ------------------------------------------------------------
PKA_Ddis         QDGIVNTPSTTQTSTTTTTTTTT-TNPHTSGLSLQH---------------------AHS
17649_Tthe       ------------------------------------------------------------
18333_Tthe       --NSDYYPTQK-------------------------------------------------
2171_Tthe        ------------------------------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ------------------------------------------------------------
CC1G_04466_Ccin  ------------------------------------------------------------
CC1G_01089_Ccin  ------------------------------------------------------------
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    ------------------------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ----------------------------------------A---------PA---LC---
PRKX_Hsap        ----------------------------------------A---------PA---LC---
PKACg_Hsap       ----------------------------------------R---------GD---FL---
PKACb_Hsap       ----------------------------------------K---------ED---FL---
PKACa_Hsap       ----------------------------------------K---------ED---FL---
Pka-C1_Dmel      ----------------------------------------K---------EE---FE---
Pka-C2_Dmel      ----------------------------------------S---------RE---FE---
CG12069_Dmel     ----------------------------------------R---------ED---FN---
PKA-C3_Dmel      S--------------------IE-----EDDGNETDDEEDD---------DE---SE---
PRKX_Mmus        ----------------------------------------A---------PA---AD---
PKACb_Mmus       ----------------------------------------K---------ED---FL---
PKACa_Mmus       ----------------------------------------K---------ED---FL---
kin-1_Cele       ----------------------------------------R---------ED---FK---
F47F2.1_Cele     ------------------------------------------------------------
TPK1_Scer        --------------------------------------------------------K---
TPK2_Scer        --------------------------------------------------------S---
TPK3_Scer        --------------------------------------------------------K---
DDB0185224_Ddis  ----------------------------------------Q---------DN---FN---
pk4_Ddis         ----------------------------------------S---------KD---FE---
PKA_Ddis         SYTPSNVLHSPTHFQSSLPTRLDTNPITTPIRQQQQSQQQLQQQQ-----LQ---QI---
17649_Tthe       -------------------------P-----------------------------LN---
18333_Tthe       ------------------------NPLEQIE---FQAKQNIQYAYTQKQKNN---QN---
2171_Tthe        ------------------------------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ----------------------------------------Q---------RC---L----
CC1G_04466_Ccin  --------------------------------------------------------P---
CC1G_01089_Ccin  ----------------------------------------E---------ER---FEKPV
AqueK013_Aque    ----------------------------------------E---------EDEENWD---
AqueK014_Aque    ----------------------------------------K---------TE---FQ---
AqueK015_Aque    ----------------------------------------S---------PI---LS---
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       ------------------------------------------------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      ------------------------------------------------------------
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       ------------------------------------------------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     ------------------------------------------------------------
TPK1_Scer        ------------------------------------------------------------
TPK2_Scer        ------------------------------------------------------------
TPK3_Scer        ------------------------------------------------------------
DDB0185224_Ddis  --Q---------------------------------------------------------
pk4_Ddis         --ELTTFMKSSCPMLLRFSGVENSYHILEKLNNIITQSLEGLPKTPQCSQPPFNQLIPLS
PKA_Ddis         ------------------------------------------------------------
17649_Tthe       ------------------------------------------------------------
18333_Tthe       ------------------------------------------------------------
2171_Tthe        ------------------------------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ------------------------------------------------------------
CC1G_04466_Ccin  ------------------------------------------------------------
CC1G_01089_Ccin  PDP---------------------------------------------------------
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    ------------------------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       ------------------------------------------------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      ------------------------------------------------------------
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       ------------------------------------------------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     ------------------------------------------------------------
TPK1_Scer        ------------------------------------------------------------
TPK2_Scer        ------------------------------------------------------------
TPK3_Scer        ------------------------------------------------------------
DDB0185224_Ddis  ------------------------------------------------------------
pk4_Ddis         NTTTLTPNNYNNNNNNSNNNNNSNNNNNNNSNNNNSNNNNSNNSNNNNNNSNNNNSNNNN
PKA_Ddis         ------------------------------------------------------------
17649_Tthe       ------------------------------------------------------------
18333_Tthe       ------------------------------------------------------------
2171_Tthe        ------------------------------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ------------------------------------------------------------
CC1G_04466_Ccin  ------------------------------------------------------------
CC1G_01089_Ccin  ------------------------------------------------------------
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    ------------------------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       ------------------------------------------------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      ------------------------------------------------------------
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       ------------------------------------------------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     ------------------------------------------------------------
TPK1_Scer        ------------------------------------------------------------
TPK2_Scer        ------------------------------------------------------------
TPK3_Scer        ------------------------------------------------------------
DDB0185224_Ddis  -------------------------------------------QLQNNNNSNNNSNNNNN
pk4_Ddis         SNNNNSNNNNNNSNNNNSNNNNSSNNNNNYSGFNDQQQQQQQQQQQQQQQQQQQ------
PKA_Ddis         ------------------------------------------------------------
17649_Tthe       ------------------------------------------------------------
18333_Tthe       ------------------------------------------------------------
2171_Tthe        ------------------------------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ------------------------------------------------------------
CC1G_04466_Ccin  ------------------------------------------------------------
CC1G_01089_Ccin  ------------------------------------------------------------
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    ------------------------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------P---------SPE-----------------------------------------
PRKX_Hsap        ------P---------SPE-----------------------------------------
PKACg_Hsap       ----------------YR------------------------------------------
PKACb_Hsap       ----------------KK------------------------------------------
PKACa_Hsap       ----------------KK------------------------------------------
Pka-C1_Dmel      ----------------DK------------------------------------------
Pka-C2_Dmel      ----------------ERW-----------------------------------------
CG12069_Dmel     ----------------KKF-----------------------------------------
PKA-C3_Dmel      ------E---------SSS-----------------------------------------
PRKX_Mmus        ------P---------KPR-----------------------------------------
PKACb_Mmus       ----------------RK------------------------------------------
PKACa_Mmus       ----------------KK------------------------------------------
kin-1_Cele       ----------------QR------------------------------------------
F47F2.1_Cele     ------H---------MKL-----------------------------------------
TPK1_Scer        ------Q---------FIA-----------------------------------------
TPK2_Scer        ------Q---------LPQ-----------------------------------------
TPK3_Scer        ------K---------PML-----------------------------------------
DDB0185224_Ddis  NNIINNNFLQNSQQTNQSLQF---S----------------------------TTQPNL-
pk4_Ddis         --------QQQQQQQHQQQKHQQTQHSQQHQQQYQQHIQQNNQYQQNQNITQSSQIPQFK
PKA_Ddis         ------P---------PPT-----------------------------------------
17649_Tthe       ----------------QQG-----------------------------------------
18333_Tthe       ------Q---------AQI-----------------------------------------
2171_Tthe        ------R---------NQI-----------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ----------------EDQ-----------------------------------------
CC1G_04466_Ccin  ------R---------FSA-----------------------------------------
CC1G_01089_Ccin  ------E---------LVQ-----------------------------------------
AqueK013_Aque    ----------------DF------------------------------------------
AqueK014_Aque    ----------------RK------------------------------------------
AqueK015_Aque    ------G---------AGS-----------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        ------------------------------------------------------------
PKACg_Hsap       ------------------------------------------------------------
PKACb_Hsap       ------------------------------------------------------------
PKACa_Hsap       ------------------------------------------------------------
Pka-C1_Dmel      ------------------------------------------------------------
Pka-C2_Dmel      ------------------------------------------------------------
CG12069_Dmel     ------------------------------------------------------------
PKA-C3_Dmel      ------------------------------------------------------------
PRKX_Mmus        ------------------------------------------------------------
PKACb_Mmus       ------------------------------------------------------------
PKACa_Mmus       ------------------------------------------------------------
kin-1_Cele       ------------------------------------------------------------
F47F2.1_Cele     ------------------------------------------------------------
TPK1_Scer        ------------------------------------------------------------
TPK2_Scer        ------------------------------------------------------------
TPK3_Scer        ------------------------------------------------------------
DDB0185224_Ddis  ------------------------------------------------NNFYDIPKQPII
pk4_Ddis         SNNIQSLIHNNQQHYTQNNLVNNNNNTNNNNNNNNYNNKTYYQPSVHENQYMASAIAPIH
PKA_Ddis         ------------------------------------------------------------
17649_Tthe       ------------------------------------------------------------
18333_Tthe       ------------------------------------------------------------
2171_Tthe        ------------------------------------------------------------
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ------------------------------------------------------------
CC1G_04466_Ccin  ------------------------------------------------------------
CC1G_01089_Ccin  ------------------------------------------------------------
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    ------------------------------------------------------------
AqueK015_Aque    ------------------------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ------------------------------------------------------------
GK006_Glam       ------------------------------------------------------------


PRKY_Hsap        --------------------A-------------------------R-S-P-EAP-----
PRKX_Hsap        --------------------A-------------------------L-S-P-EPP-----
PKACg_Hsap       --------------------W-------------------------G-N-P-AQN-----
PKACb_Hsap       --------------------W-------------------------E-N-P-TQN-----
PKACa_Hsap       --------------------W-------------------------E-S-P-AQN-----
Pka-C1_Dmel      --------------------W-------------------------R-R-N-PTN-----
Pka-C2_Dmel      --------------------N-------------------------H-Q-T-QSP-----
CG12069_Dmel     --------------------A-------------------------T-N-T-PSP-----
PKA-C3_Dmel      --------------------V-------------------------QTA-K-GVR-----
PRKX_Mmus        --------------------T---------------------------S-S-QKA-----
PKACb_Mmus       --------------------W-------------------------E-N-P-PPS-----
PKACa_Mmus       --------------------W-------------------------E-T-P-SQN-----
kin-1_Cele       --------------------W-------------------------E-N-P-AQN-----
F47F2.1_Cele     --------------------S-------------------------I-T-P-TRE-----
TPK1_Scer        --------------------Q-------------------------A-R-V-TVG-----
TPK2_Scer        --------------------K-------------------------S-L-V-SKG-----
TPK3_Scer        --------------------Q-------------------------Y-R-D-TSG-----
DDB0185224_Ddis  CSSPIVNIPPPFYLDGSIDPV-------------------------E-N-I-DWK-----
pk4_Ddis         ---NHQSSPNPFYQQKLTIPQQTNNQSTRISAQFIIQNINNQQIQGT-Y-I-NFN-----
PKA_Ddis         ----------------VNSFF-------------------------LPP-P-VNA-----
17649_Tthe       --------------------K-------------------------I-Q-T-KSD-----
18333_Tthe       --------------------I-------------------------K-K-E-QND-----
2171_Tthe        --------------------K-------------------------N-F-K-AKAACIKI
26485_Tthe       ------------------------------------------------------------
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  --------------------R-------------------------V-R-L-QGS-----
CC1G_04466_Ccin  --------------------R-------------------------P-Q-R-PKG-----
CC1G_01089_Ccin  --------------------P-------------------------V-S-K-RPP-----
AqueK013_Aque    --------------------S-------------------------E-HLPTESD-----
AqueK014_Aque    --------------------W-------------------------E-S-P-PAQ-----
AqueK015_Aque    --------------------R-------------------------E-A-R-YTR-----
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       ----------------------------------------------------AYP-----
GK006_Glam       ----------------------------------------------A-Y-I-DPP-----


PRKY_Hsap        ----------------AYRLQDCDALVTMGTGTFGRV--HLVKEKT-------AKHFFAL
PRKX_Hsap        ----------------VYSLQDFDTLATVGTGTFGRV--HLVKEKT-------AKHFFAL
PKACg_Hsap       ----------------TASSDQFERLRTLGMGSFGRV--MLVRHQE-------TGGHYAM
PKACb_Hsap       ----------------NAGLEDFERKKTLGTGSFGRV--MLVKHKA-------TEQYYAM
PKACa_Hsap       ----------------TAHLDQFERIKTLGTGSFGRV--MLVKHKE-------TGNHYAM
Pka-C1_Dmel      ----------------TAALDDFERIKTLGTGSFGRV--MIVQHKP-------TKDYYAM
Pka-C2_Dmel      ----------------YTNLENYITRAVLGNGSFGTV--MLVREKSG-------KNYYAA
CG12069_Dmel     ----------------STGLDDYEIKATLGSGSFGKV--QLVRERES-------GVYYAS
PKA-C3_Dmel      ----------------KYHLDDYQIIKTVGTGTFGRV--CLCRDRI-------SEKYCAM
PRKX_Mmus        ----------------GHSLQDWDTIATVGTGTFGRV--NLVKEKT-------GRQYCAL
PKACb_Mmus       ----------------NAGLEDFERKKTLGTGSFGRV--MLVKHKA-------TEQYYAM
PKACa_Mmus       ----------------TAQLDQFDRIKTLGTGSFGRV--MLVKHKE-------SGNHYAM
kin-1_Cele       ----------------TACLDDFDRIKTLGTGSFGRV--MLVKHKQ-------SGNYYAM
F47F2.1_Cele     ----------------SFSLSQLERIITIGKGTFGRV--ELARDKI-------TGAHYAL
TPK1_Scer        ----------------SIVYKNFQILRTLGTGSFGRV--HLIRSRH-------NGRYYAM
TPK2_Scer        ----------------KYTLHDFQIMRTLGTGSFGRV--HLVRSVH-------NGRYYAI
TPK3_Scer        ----------------KYSLSDFQILRTLGTGSFGRV--HLIRSNH-------NGRFYAL
DDB0185224_Ddis  ----------------RTKISDFNFYGSLGSGSFGTA--KLCRHRG-------SGLFFCS
pk4_Ddis         ----------------SCKLSDFKLFDLLGSGSFAKV--RLCQHIP-------SERLFCM
PKA_Ddis         ----------------RERLKEFKQIRVIGTGTFGKV--YLIQNTK-------DGCYYAM
17649_Tthe       ----------------TMKISDFEIFATLGTGTFGRV--RQVKLKGDT-----NKEIFAL
18333_Tthe       ----------------TLNLNQFNIKTTLGTGSFGRV--KLAKLKGN------EKDVFAL
2171_Tthe        QSLITLLIKNNFSTFLLFCESSKKQQQSINRCSFGRV--RLAKQKS-------TGEYVAL
26485_Tthe       -------------------LSDYEIFQTLGTGSFGRV--KLAKKKN-------TTQYVAL
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  ----------------GLKLSDFEVRGTLGTGTFGKV--LLVRHKTARDR-HGAQSHFAM
CC1G_04466_Ccin  ----------------TYRLSDFSIQRTLGTGSFGRV--HLVRSKH-------NGRFYAI
CC1G_01089_Ccin  ----------------PLGLQDLEIIKALGDGAEGRV--YLVRTTRSSHPLDRPGTLYAV
AqueK013_Aque    ----------------SIPLIDFSDDGPLNEGANPPNYWDIISHSA-----NLADESHAP
AqueK014_Aque    ----------------TGKLDDFDRIKTLGTGSFGRV--MLVQHKK-------TSKYYAM
AqueK015_Aque    ----------------KFSLRELEIQQTIGTGTFGRV--VLTREIS-------SRQYYAL
PKA-1_Smoe       -------------------IEEFELGRVLGTGSFGRV--QVAHHKA-------NKQVCAV
PKA-2_Smoe       -------------------IEEFELGRVLGTGSFGRV--QVAHHKA-------NKQVCAV
GK005_Glam       ----------------ELSYKDLRHIKNIGSGSFGRV--TLAQHID-------TGKYYAV
GK006_Glam       ----------------PTSPDEFTFMKVLGKGSFGTV--CLAKHKA-------NNKIYAL


PRKY_Hsap        KVM-------------------SIPDV-IRRKQ----EQH---VHNEKSVLKEVS-HPFL
PRKX_Hsap        KVM-------------------SIPDV-IRLKQ----EQH---VHNEKSVLKEVS-HPFL
PKACg_Hsap       KIL-------------------NKQKV-VKMKQ----VEH---ILNEKRILQAID-FPFL
PKACb_Hsap       KIL-------------------DKQKV-VKLKQ----IEH---TLNEKRILQAVN-FPFL
PKACa_Hsap       KIL-------------------DKQKV-VKLKQ----IEH---TLNEKRILQAVN-FPFL
Pka-C1_Dmel      KIL-------------------DKQKV-VKLKQ----VEH---TLNEKRILQAIQ-FPFL
Pka-C2_Dmel      KMM-------------------SKEDL-VRLKQ----VAH---VHNEKHVLNAAR-FPFL
CG12069_Dmel     KQL-------------------SKDQI-VKTKQ----VSH---VMSEKNVLRSMT-FPNT
PKA-C3_Dmel      KIL-------------------AMTEV-IRLKQ----IEH---VKNERNILREIR-HPFV
PRKX_Mmus        KIM-------------------SIPDV-IRLKQ----EQH---VQNEKAVLKEIN-HPFL
PKACb_Mmus       KIL-------------------DKQKV-VKLKQ----IEH---TLNEKRILQAVE-FPFL
PKACa_Mmus       KIL-------------------DKQKV-VKLKQ----IEH---TLNEKRILQAVN-FPFL
kin-1_Cele       KIL-------------------DKQKV-VKLKQ----VEH---TLNEKRILQAID-FPFL
F47F2.1_Cele     KVL-------------------NIRRV-VDMRQ----TQH---VHNEKRVLLQLK-HPFI
TPK1_Scer        KVL-------------------KKEIV-VRLKQ----VEH---TNDERLMLSIVT-HPFI
TPK2_Scer        KVL-------------------KKQQV-VKMKQ----VEH---TNDERRMLKLVE-HPFL
TPK3_Scer        KTL-------------------KKHTI-VKLKQ----VEH---TNDERRMLSIVS-HPFI
DDB0185224_Ddis  KTL-------------------RRETI-VHEKH----KEH---VNNEINIMLNIS-HPYI
pk4_Ddis         KIL-------------------NQNKI-IRLRQ----EVH---VCNEKQVLMLTD-NPFI
PKA_Ddis         KCL-------------------NKAYV-VQLKQ----VEH---LNSEKSILSSIH-HPFI
17649_Tthe       KML-------------------KKTEI-VRLNQ----VEH---INSEKKILQSVK-HPFI
18333_Tthe       KMM-------------------KKIEI-VKLKQ----VEH---IKSEKKILSQIK-HPFL
2171_Tthe        KML-------------------KKAEI-LRLKQ----VDH---IISENTILSNIN-HPFL
26485_Tthe       KVL-------------------KKAEI-IRLKQ----VDH---IINENTILSNLN-HPFI
PRKX_Spur        ------------------------------------------------------------
PKA_Spur         ------------------------------------------------------------
CC1G_05183_Ccin  KVL-------------------RKTVI-VQLRQ----VEH---VNAERYILSRVN-HPFI
CC1G_04466_Ccin  KVL-------------------NKERI-VRMKQ----IEH---TNNEMKMLESVQ-HPFI
CC1G_01089_Ccin  KTQ-------------------KKKYKRQALPP----EAHMLEKDNERTALALMDWNPFI
AqueK013_Aque    AILSAIKGIVDEWDIVGIFLGIDNANI-ERIKSNNSNVDH---RRKEI-IIAWLR-YGNA
AqueK014_Aque    KIL-------------------DKQKV-VKLKQ----VEH---TLNEKRILSSIN-FPFV
AqueK015_Aque    KIM-------------------SIAEV-IRLKQ----VEH---VNNEKEILTSLQ-HPFI
PKA-1_Smoe       KSL-------------------SKASI-VKTKQ----ACE---HSFQKNILQRLD-FPYI
PKA-2_Smoe       KSL-------------------SKASI-VKTKQ----ACE---HSFQKNILQRLD-FPYI
GK005_Glam       KAM-------------------SKRKI-IALRQ----VAH---INNECSILRVVR-SPFI
GK006_Glam       KVL-------------------TKQHV-IESRE----VEH---AISERSILASLN-HPFL


PRKY_Hsap        I--R-LF------------WTWHEERFLYMLMEYVPGGELFSYLRNRGHFSSTTGLFYSA
PRKX_Hsap        I--R-LF------------WTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSA
PKACg_Hsap       V--K-LQ------------FSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAA
PKACb_Hsap       V--R-LE------------YAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA
PKACa_Hsap       V--K-LE------------FSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA
Pka-C1_Dmel      V--S-LR------------YHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAA
Pka-C2_Dmel      I--Y-LV------------DSTKCFDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAA
CG12069_Dmel     V--N-LI------------ASYKDFDSLYLVLPLIGGGELFTYHRKVRKFTEKQARFYAA
PKA-C3_Dmel      I--S-LE------------WSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAA
PRKX_Mmus        I--K-LL------------WTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVASVFYAT
PKACb_Mmus       V--R-LE------------YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA
PKACa_Mmus       V--K-LE------------FSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAA
kin-1_Cele       V--N-MT------------FSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAA
F47F2.1_Cele     V--K-MY------------ASEKDSNHLYMIMEFVPGGEMFSYLRASRSFSNSMARFYAS
TPK1_Scer        I--R-MW------------GTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAA
TPK2_Scer        I--R-MW------------GTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAA
TPK3_Scer        I--R-MW------------GTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAA
DDB0185224_Ddis  V--K-TY------------STFNTPTKIHFIMEYAGKKDLFHHLRANKCFTEQTTKLIVA
pk4_Ddis         V--K-LY------------STFKDDRYLYFLQEFIPGGELFDYIRANGSLSLYVTQIYAA
PKA_Ddis         V--N-LY------------QAFQDEKKLYLLFEYVAGGEVFTHLRKSMKFSNSTAKFYAA
17649_Tthe       V--Q-MK------------QSFQDDKYIYMLFEYIQGGELFSRLRKEGRFSNDVGLFYTC
18333_Tthe       V--E-LK------------GTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSNDISLFYIT
2171_Tthe        V--N-LSTFYLHQQVIKMIGFTQDDRFLYFVLEYVAGGELFTYLRNKGKLDNPEALFYAA
26485_Tthe       V--K-MD------------GFCQDSRYLYLVLEFVSGGELFTYLRSVGRLETNHACFYAA
PRKX_Spur        -----------------------------MLLEYACGGELFTYLRNSGRFNNDTGKFYAM
PKA_Spur         -----------------------------MVLDYIPGGEMFSHLRRIGRFSEPHSRFYAA
CC1G_05183_Ccin  V--D-LF------------ATFQDSLNVYMLMSYVPGGELFTHLRRAQRFTPDVTRFYLA
CC1G_04466_Ccin  I--N-LW------------GSFQDSSNLYMVMDFVPGGELFTLLRRSNRFPDPVAKFYAA
CC1G_01089_Ccin  A--G-VI------------DILHDVKNIYTILELIPSGTLLSLIKSHAPMPPTIAAFYFA
AqueK013_Aque    TRQHLIE------------ALKEDNSYLYMLLEFVSGGEMFSHLRRIGRFSESHSRFYAS
AqueK014_Aque    V--N-LE------------FHFKDNSYLYMLLEFVSGGEMFSHLRRIGRFSESHSRFYAS
AqueK015_Aque    V--N-LA------------WTHHDNRFLYMLLEYVPGGELFTYLRTAQRFDNATSMFFAS
PKA-1_Smoe       V--N-LL------------GYCQDDRCVHLVMEYVCGGEFFTYLRHTGRFDEATSRFYAS
PKA-2_Smoe       V--N-LL------------GYCQDDRCVHLVMEYVCGGEFFTYLRHTGRFDEATSRFYAS
GK005_Glam       I--R-QY------------GTYQDDKNVYIILDFIQGGELFYHLRRYNKFPLQVVKFFAV
GK006_Glam       M--R-LY------------GAFQTPTRLIMVLEYVPGGELFFHLKKKVTFDESYVKLVAA
                                               :        .:   :    :      :

PRKY_Hsap        EIIC--------------------------------------------------------
PRKX_Hsap        EIIC--------------------------------------------------------
PKACg_Hsap       QVVL--------------------------------------------------------
PKACb_Hsap       QIVL--------------------------------------------------------
PKACa_Hsap       QIVL--------------------------------------------------------
Pka-C1_Dmel      QIVL--------------------------------------------------------
Pka-C2_Dmel      QVAL--------------------------------------------------------
CG12069_Dmel     QVFL--------------------------------------------------------
PKA-C3_Dmel      EIVS--------------------------------------------------------
PRKX_Mmus        EIVC--------------------------------------------------------
PKACb_Mmus       QIVL--------------------------------------------------------
PKACa_Mmus       QIVL--------------------------------------------------------
kin-1_Cele       QIVL--------------------------------------------------------
F47F2.1_Cele     EIVC--------------------------------------------------------
TPK1_Scer        EVCL--------------------------------------------------------
TPK2_Scer        EVIL--------------------------------------------------------
TPK3_Scer        EVCL--------------------------------------------------------
DDB0185224_Ddis  EIVL--------------------------------------------------------
pk4_Ddis         EIVL--------------------------------------------------------
PKA_Ddis         EIVL--------------------------------------------------------
17649_Tthe       QILL--------------------------------------------------------
18333_Tthe       EIYL--------------------------------------------------------
2171_Tthe        QVYIFVCDLLSYDNHFETQQINLKIRLSYFLLQQIQQMSQNQSKIFFQNNLRKNTNILPR
26485_Tthe       QVTL--------------------------------------------------------
PRKX_Spur        EIIS--------------------------------------------------------
PKA_Spur         QIVL--------------------------------------------------------
CC1G_05183_Ccin  TIIL--------------------------------------------------------
CC1G_04466_Ccin  EVAL--------------------------------------------------------
CC1G_01089_Ccin  NMFS--------------------------------------------------------
AqueK013_Aque    QIVL--------------------------------------------------------
AqueK014_Aque    QIVL--------------------------------------------------------
AqueK015_Aque    EIVL--------------------------------------------------------
PKA-1_Smoe       QVLL--------------------------------------------------------
PKA-2_Smoe       QVLL--------------------------------------------------------
GK005_Glam       EILL--------------------------------------------------------
GK006_Glam       QLVL--------------------------------------------------------
                  :

PRKY_Hsap        ------------------------AIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFA
PRKX_Hsap        ------------------------AIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFA
PKACg_Hsap       ------------------------AVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFA
PKACb_Hsap       ------------------------TFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA
PKACa_Hsap       ------------------------TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA
Pka-C1_Dmel      ------------------------AFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFA
Pka-C2_Dmel      ------------------------ALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFT
CG12069_Dmel     ------------------------ALEYLHHCSLLYRDLKPENIMMDKNGYLKVTDFGFA
PKA-C3_Dmel      ------------------------ALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFA
PRKX_Mmus        ------------------------AIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFA
PKACb_Mmus       ------------------------TFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA
PKACa_Mmus       ------------------------TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA
kin-1_Cele       ------------------------AFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFA
F47F2.1_Cele     ------------------------ALEYIHSLGIVYRDLKPENLMLSKEGHIKMADFGFA
TPK1_Scer        ------------------------ALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFA
TPK2_Scer        ------------------------ALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFA
TPK3_Scer        ------------------------ALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFA
DDB0185224_Ddis  ------------------------AIEYLHAENIIYRDLKPENILIDEKGHIKLTDFGFS
pk4_Ddis         ------------------------ALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFA
PKA_Ddis         ------------------------ALEFLHKQNIVYRDLKPENLLIDNQGHIKITDFGFA
17649_Tthe       ------------------------ALQYLHQHDIVYRDLKPENLLIDKEGNIKITDFGFA
18333_Tthe       ------------------------ALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFA
2171_Tthe        QYFYLTNQIKQPKIETKKRYFKVSMFEYLHNKNIVYRDLKPENILIGSDGYLKLTDFGFA
26485_Tthe       ------------------------MFEYLHTKNIIYRDLKPENLLIADDGYLKLTDFGFA
PRKX_Spur        ------------------------AIDYLHKETIVYRDLKPENILLDSEGHVKLTDFGFA
PKA_Spur         ------------------------AFEYLHHLDLIYRDLKPENILIQENGYIAVTDFGFA
CC1G_05183_Ccin  ------------------------ALKYLHSFNIIYRDLKPENLLLDSRGYLRLTDFGFA
CC1G_04466_Ccin  ------------------------ALNYMHSLDIVYRDLKPENILLNVDGHIKIADFGFA
CC1G_01089_Ccin  ------------------------AIEYVHALGLVHRDIKPDNFLLGEDGYLSLTDFGLT
AqueK013_Aque    ------------------------AFEYLHYLDIVYRDLKPENLLIDQHGYVKVTDFGFA
AqueK014_Aque    ------------------------AFEYLHYLDIVYRDLKPENLLIDQHGYVKVTDFGFA
AqueK015_Aque    ------------------------VMDYLHSQYIVYRDLKPENILIDSTGHIKLCDFGFA
PKA-1_Smoe       ------------------------AFEHIHGMDIIYRDLKPENLLLDEKGNIKIADFGFA
PKA-2_Smoe       ------------------------AFEHIHGMDIIYRDLKPENLLLDEKGNIKIADFGFA
GK005_Glam       ------------------------ALGYLHNLGIAYRDLKLENVLVDNTGHIKLADLGFA
GK006_Glam       ------------------------AIEYLHDMNIVIRDLKPENILLQANGYIKVTDFGLS
                                          . .:*   :  **:* :*.::   * : : *:*::

PRKY_Hsap        KKL----------VDRT---WTLCGTPEYLAPEVIQS---------------KGHGRAVD
PRKX_Hsap        KKL----------VDRT---WTLCGTPEYLAPEVIQS---------------KGHGRAVD
PKACg_Hsap       KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD
PKACb_Hsap       KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD
PKACa_Hsap       KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD
Pka-C1_Dmel      KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD
Pka-C2_Dmel      KRVD----------GRT---STLCGTPEYLAPEIVQL---------------RPYNKSVD
CG12069_Dmel     KKVE----------TRT---MTLCGTPEYLPPEIIQS---------------KPYGTSVD
PKA-C3_Dmel      KKL----------RDRT---WTLCGTPEYIAPEIIQS---------------KGHNKAVD
PRKX_Mmus        KKL----------VDRT---WTLCGTPEYLAPEVIQS---------------KGHGRAVD
PKACb_Mmus       KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD
PKACa_Mmus       KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD
kin-1_Cele       KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD
F47F2.1_Cele     KELR----------DRT---YTICGTPDYLAPESLAR---------------TGHNKGVD
TPK1_Scer        KYVP----------DVT---YTLCGTPDYIAPEVVST---------------KPYNKSID
TPK2_Scer        KEVQ----------TVT---WTLCGTPDYIAPEVITT---------------KPYNKSVD
TPK3_Scer        KYVP----------DVT---YTLCGTPDYIAPEVVST---------------KPYNKSVD
DDB0185224_Ddis  KKTVG--------GKNT---SSVCGTFDYMAPEILNS-S-------------NGHGKPVD
pk4_Ddis         KRITE----------NT---KSMCGTPEYIAPEILS--G-------------HGHGKSAD
PKA_Ddis         KRV----------EDRT---FTLCGTPEYLAPEIIQS---------------KGHGKAVD
17649_Tthe       KKLD---------NDRT---FTLCGTPEYLAPEIIKGSR-------------VGYGKSVD
18333_Tthe       KIMD---------SART---YTLCGTPEYLAPEIIQGAK-------------TGYGKSVD
2171_Tthe        KYCD----------SRT---YTLCGTPEYLAPEILLN---------------KGHGKPVD
26485_Tthe       KVVE----------GRT---YTLCGTPEYLAPEILLN---------------KGHGKAVD
PRKX_Spur        KKLV---------DNRT---WTLCGTPEYLAPEIIQS---------------KGHGKAVD
PKA_Spur         KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD
CC1G_05183_Ccin  KIVD----------DRT---WTLCGTPEYLAPEIIQS---------------DGHGKAAD
CC1G_04466_Ccin  KLCA----------TTT---WTLCGTPDYLAPEIVSQ---------------QRYNKSVD
CC1G_01089_Ccin  VPVDDF--------QVD---WVDIGTPLYRPPEMDVRASPAQEKEGDEEEVDLDDRRSVD
AqueK013_Aque    KRVK----------GRT---WTLCGTPEYLAPEIILS-----------------------
AqueK014_Aque    KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNRAVD
AqueK015_Aque    KRLA---------DRRT---YTLCGTPEYLAPEIIQG---------------KGHGREVD
PKA-1_Smoe       KQID----------RRT---YTLCGTPDYLAPEIILN---------------KGHGKPVD
PKA-2_Smoe       KQID----------RRT---YTLCGTPDYLAPEIILN---------------KGHGKPVD
GK005_Glam       KRLVEKNADGDTVSQLT---FSIVGTPEYLAPEIIRS---------------TGHDMSAD
GK006_Glam       KQNL----------SMTLGAKTMAGTSEYFSPEQVQN---------------CGHGKGVD
                                         **  * .**

PRKY_Hsap        WWALGILIFEMLSGFPPFFD--DN-P--FGIYQKILAG--KLYFPR-HLD-----FHVKT
PRKX_Hsap        WWALGILIFEMLSGFPPFFD--DN-P--FGIYQKILAG--KIDFPR-HLD-----FHVKD
PKACg_Hsap       WWALGVLIYEMAVGFPPFYA--DQ-P--IQIYEKIVSG--RVRFPS-KLS-----SDLKH
PKACb_Hsap       WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFS-----SDLKD
PKACa_Hsap       WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFS-----SDLKD
Pka-C1_Dmel      WWALGVLVYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFG-----SDLKD
Pka-C2_Dmel      WWAFGILVYEFVAGRSPFAIHNRD-V--ILMYSKICIC--DYKMPS-YFT-----SQLRS
CG12069_Dmel     WWAFGVLVFEFVAGHSPFSAHNRD-V--MSMYNKICEA--DYKMPS-YFS-----GALRH
PKA-C3_Dmel      WWALGVLIYEMLVGYPPFYD--EQ-P--FGIYEKILSG--KIEWER-HMD-----PIAKD
PRKX_Mmus        WWALGILIFEMLSGFPPFFD--DN-P--FGIYQKILAC--KIDFPR-QLD-----FTSKD
PKACb_Mmus       WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFS-----SDLKD
PKACa_Mmus       WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFS-----SDLKD
kin-1_Cele       WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVKFPS-HFS-----NELKD
F47F2.1_Cele     WWALGILIYEMMVGKPPFRG--KT-T--SEIYDAIIEH--KLKFPR-SFN-----LAAKD
TPK1_Scer        WWSFGILIYEMLAGYTPFYD--SN-T--MKTYEKILNA--ELRFPP-FFN-----EDVKD
TPK2_Scer        WWSLGVLIYEMLAGYTPFYD--TT-P--MKTYEKILQG--KVVYPP-YFH-----PDVVD
TPK3_Scer        WWSFGVLIYEMLAGYTPFYN--SN-T--MKTYENILNA--ELKFPP-FFH-----PDAQD
DDB0185224_Ddis  WWALGVVVYELVTGKLPFSN--SK-E--SLLNRKADFQ--LIFQNS-YLS-----DEIKD
pk4_Ddis         WWSLGILIYEMLVGVPPFVS--EGSQ--NDIFRLIREA--RIQVPP-EVD-----QVARD
PKA_Ddis         WWALGILIFEMLAGYPPFYD--DD-T--FAIYNKILAG--RITFPL-GFD-----VDAKD
17649_Tthe       WWALGILVFEMLSGYPPFYD--NE-P--IGIYKKIIAG--IIEFPR-FFD-----NKAKD
18333_Tthe       WWALGVLIFEMLSGHPPFYD--CD-P--MGIYQKIVNS--VINFPE-FFS-----LRAKD
2171_Tthe        WWCLGILIYEMLAGIDPFND--ED-P--MAIYQKILKG--KVKFPR-NFD-----KNAKS
26485_Tthe       WWTLGILIYEMNAGIDPFTD--ED-P--MAIYQKILKG--KVKFPR-NFD-----KNAKS
PRKX_Spur        WWALGILIYEMLAGYPPFYD--EN-P--FGIYEKILAC--KIDWPQ-SIG-----SKPKK
PKA_Spur         WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFS-----ADLKD
CC1G_05183_Ccin  WWACGVLCYEMLVGYPPFFD--ES-P--YGIYEKILNG--QIHWPR-HID-----RLSKD
CC1G_04466_Ccin  WYALGVLIFEMLSGLPPYHQ--PE-PNHLALYEKIMRGPKNIRWPAAAFN-----ENATD
CC1G_01089_Ccin  WYSSAVVLYEMVTRTVPFYG--RT-K--LQTNALKVEK--KYSFPK-DIRI---GSHFKD
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    WWAMGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFT-----ADLKD
AqueK015_Aque    WWALGILVYEMLVGYPPFFD--EH-P--FRIYEKILEG--KVDWPK-VIS-----STAKD
PKA-1_Smoe       WWAFGVLIYEMLAGYPPFYD--DD-A--IGTYQKILAG--KLQFPG-HFSRRQTSCSAKD
PKA-2_Smoe       WWAFGVLIYEMLAGYPPFYD--DD-A--IGTYQKILAG--KLQFPG-HFSRRQISCSAKD
GK005_Glam       WWAFGVLIYEMLTGSPPFFD--DN-P--DMTCKKILGG--KITFAS-GFD-----KAAKD
GK006_Glam       MWALGTIIYELLTGSPPFYS--DD-K--RAMFRKIIGE--QPKMPS-YFK-----DDLKD


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        LIKKLLVVDRTRRLGN-MK--------NGANDVKHHRWFRSVDWEAVPQR-KLKPPI---
PKACg_Hsap       LLRSLLQVDLTKRFGN-LR--------NGVGDIKNHKWFATTSWIAIYEK-KVEAPF---
PKACb_Hsap       LLRNLLQVDLTKRFGN-LK--------NGVSDIKTHKWFATTDWIAIYQR-KVEAPF---
PKACa_Hsap       LLRNLLQVDLTKRFGN-LK--------NGVNDIKNHKWFATTDWIAIYQR-KVEAPF---
Pka-C1_Dmel      LLRNLLQVDLTKRYGN-LK--------AGVNDIKNQKWFASTDWIAIFQK-KIEAPF---
Pka-C2_Dmel      LVESLMQVDTSKRLGN-SN--------DGSSDVKSHPWFQGVDWFGILNQ-EVTAPY---
CG12069_Dmel     LVDHLLQVDLSKRFGN-LI--------NGNRDIKEHEWFKDVEWIPLLNQ-TVNAPY---
PKA-C3_Dmel      LIKKLLVNDRTKRLGN-MK--------NGADDVKRHRWFKHLNWNDVYSK-KLKPPI---
PRKX_Mmus        LIKKLLVVDRTRRLGN-MK--------NGAEDIKRHRWFRGVEWESVPQR-KLKPPI---
PKACb_Mmus       LLRNLLQVDLTKRFGN-LK--------NGVSDIKTHKWFATTDWIAIYQR-KVEAPF---
PKACa_Mmus       LLRNLLQVDLTKRFGN-LK--------NGVNDIKNHKWFATTDWIAIYQR-KVEAPF---
kin-1_Cele       LLKNLLQVDLTKRYGN-LK--------NGVADIKNHKWFGSTDWIAIYQK-KITPPSFSK
F47F2.1_Cele     LVKKLLEVDRTQRIGC-MK--------NGTQDVKDHKWFEKVNWDDTLHL-RVEPPI---
TPK1_Scer        LLSRLITRDLSQRLGN-LQ--------NGTEDVKNHPWFKEVVWEKLLSR-NIETPY---
TPK2_Scer        LLSKLITADLTRRIGN-LQ--------SGSRDIKAHPWFSEVVWERLLAK-DIETPY---
TPK3_Scer        LLKKLITRDLSERLGN-LQ--------NGSEDVKNHPWFNEVIWEKLLAR-YIETPY---
DDB0185224_Ddis  FIFQLLSVDPSKRLGT-FD--------S--CSIRNHKWFSDINWLHLESKYQIDGPL---
pk4_Ddis         LIEKLVVTDVEKRLGS-LE--------GGIEDIKNHPFFGAINWNSIQNR-E-SAPL---
PKA_Ddis         LIKRLLTADRTRRLGA-LK--------DGALDVKNHRWFSDINWERLYQR-RDNGPF---
17649_Tthe       LIRKLLNPDLNYRLGV-H---------DKGQSVSKHKWFRGVDWESVFNK-DIPAPW---
18333_Tthe       LVRKLLNPNIESRLGC-QDQILSNVIDQDGNSIKNHKWFKGVNWDKIYHK-QIPSPW---
2171_Tthe        LVKHLLVADLTKRYGN-LK--------GGVNDIKTHRWFADMDWDALFHK-KIPPTY---
26485_Tthe       LVKHLLVADLSKRYGN-LK--------NGANDIKNHRWFSSIDWAQLLSK-KLPVPY---
PRKX_Spur        LIEGLLVIDRTKRLGC-MR--------AGSNDIKNSDWFESIDWENVRQR-QLKPPI---
PKA_Spur         ILRSLLQVDLTKRYGN-LK--------AGVADIKLHKWFQSTDWIAIYQQ-RVDAPF---
CC1G_05183_Ccin  LIKSFLNPDRTKRLGN-ML--------GGPQDILDHPWFRGVDWDALERR-EINAPI---
CC1G_04466_Ccin  LILKLMEGDPSRRYGN-LR--------HGAGDVFAHPWFREVDWDRLAAR-EITAPY---
CC1G_01089_Ccin  LIKSLLDPEPSNRP--------------RPAEIQENKWLSRIDWDKLHEK-QYLPPH---
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    LLRNLLQVDLTKRFGN-LK--------NGVQDIKGHSWFSSTEWISIYQR-KIDAPF---
AqueK015_Aque    LIKKLLVKDVTRRLGS-LK--------DGVDDVKQHKWFRGVDWDAVLMR-KSLPLI---
PKA-1_Smoe       LVRRLLTADLTKRIGC-LK--------DGVDEIKNHSWFANVKWDNVLAK-KDTPPI---
PKA-2_Smoe       LVRRLLTADLTKRIGC-LK--------DGVDEIKNHSWFANVKWDNVLAK-KDTPPI---
GK005_Glam       LIIRLLNPDKTRRLGASIN--------NGTADIMKHAFFSGVNWSWFEKK-VVKAPI---
GK006_Glam       LLKGLLEKKPRSRLGC-RKE------NGGIKELKGHPWFNGINWDKLYRK-EYTIPY---


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        -----------VPKI-AGD----------------------------------GDTSNFE
PKACg_Hsap       -----------IPKY-TGP----------------------------------GDASNFD
PKACb_Hsap       -----------IPKF-RGS----------------------------------GDTSNFD
PKACa_Hsap       -----------IPKF-KGP----------------------------------GDTSNFD
Pka-C1_Dmel      -----------IPRC-KGP----------------------------------GDTSNFD
Pka-C2_Dmel      -----------QPTI-SGA----------------------------------EDLSNFE
CG12069_Dmel     -----------VPNI-SNP----------------------------------EDISNFD
PKA-C3_Dmel      -----------LPDV-HHD----------------------------------GDTKNFD
PRKX_Mmus        -----------VPKL-SGD----------------------------------GDISNFE
PKACb_Mmus       -----------IPKF-RGS----------------------------------GDTSNFD
PKACa_Mmus       -----------IPKF-KGP----------------------------------GDTSNFD
kin-1_Cele       GESNGRLFEALYPRV-DGP----------------------------------ADTRHFV
F47F2.1_Cele     -----------VPTL-YHP----------------------------------GDTGNFD
TPK1_Scer        -----------EPPIQQGQ----------------------------------GDTSQFD
TPK2_Scer        -----------EPPITSGI----------------------------------GDTSLFD
TPK3_Scer        -----------EPPIQQGQ----------------------------------GDTSQFD
DDB0185224_Ddis  -----------STLN-SFINCDFNINLLKKSKSYTEQQQQQQQLPQQQQQQQQNN-QLFN
pk4_Ddis         -----------KPRI-RPL----------------------------------KH-HLMD
PKA_Ddis         -----------IPKI-QHQ----------------------------------GDSSNFE
17649_Tthe       -----------TPQL-RNE----------------------------------QDASCFE
18333_Tthe       -----------IPQL-KSI----------------------------------DDVSYFE
2171_Tthe        -----------KPVV-KGK----------------------------------GDTSNYS
26485_Tthe       -----------KPVV-KAP----------------------------------NDTSNFS
PRKX_Spur        -----------VPKL-SHA----------------------------------GDTSNFD
PKA_Spur         -----------VPRV-KGP----------------------------------GDASQFD
CC1G_05183_Ccin  -----------IPRT-TSV----------------------------------DDTRHFL
CC1G_04466_Ccin  -----------LPRI-SGD----------------------------------GDASAFD
CC1G_01089_Ccin  -----------LPKNP-SA----------------------------------SK-GMWH
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    -----------VPKT-KGA----------------------------------GDPSNFD
AqueK015_Aque    -----------IPRV-SHP----------------------------------GDTRNFE
PKA-1_Smoe       -----------RPKV-AVC----------------------------------LY-----
PKA-2_Smoe       -----------RPKV-AVC----------------------------------VY-----
GK005_Glam       -----------VPKL-TDP----------------------------------ADTANYE
GK006_Glam       -----------KPTI-TDN----------------------------------LDLSNFD


PRKY_Hsap        ------------------------------------------------------------
PRKX_Hsap        TY-PEN--DWD------TAA----------------------------------------
PKACg_Hsap       DY-EEE--EL--------RI----------------------------------------
PKACb_Hsap       DY-EEE--DI--------RV----------------------------------------
PKACa_Hsap       DY-EEE--EI--------RV----------------------------------------
Pka-C1_Dmel      DY-EEE--AL--------RI----------------------------------------
Pka-C2_Dmel      NF-EFK--DRY------K------------------------------------------
CG12069_Dmel     KV-SDK--PRP------K------------------------------------------
PKA-C3_Dmel      DY-PEK--DWK------PAK----------------------------------------
PRKX_Mmus        TY-PES--ELD------KTP----------------------------------------
PKACb_Mmus       DY-EEE--EI--------RV----------------------------------------
PKACa_Mmus       DY-EEE--EI--------RV----------------------------------------
kin-1_Cele       EE-VQE--PTE------FVI----------------------------------------
F47F2.1_Cele     DY-EED--TTG------GPL----------------------------------------
TPK1_Scer        KY-PEE--DIN------YGV----------------------------------------
TPK2_Scer        QY-PEE--QLD------YGI----------------------------------------
TPK3_Scer        RY-PEE--EFN------YGI----------------------------------------
DDB0185224_Ddis  QT-LQQ--Q-N------FNF-H----------PIQP-----QQQQQQQFFNFQFNNNNFN
pk4_Ddis         ER-DEE--D-R------ISA-N----------FIKP-----D------------------
PKA_Ddis         MY-DEE--EMV------EEPPS-------------------S------------------
17649_Tthe       KY-PDS--QEG------A-R----------------------------------------
18333_Tthe       KY-PES--KDK------Q-E----------------------------------------
2171_Tthe        SY-PDS--TEL------PKP----------------------------------------
26485_Tthe       SY-PES--DTH------SPA----------------------------------------
PRKX_Spur        EY-PEE--NWE------TDA---------------------S------------------
PKA_Spur         EY-EEE--AL--------KI----------------------------------------
CC1G_05183_Ccin  HL-PPP--TAE------EIPGL-------------VGQDLPQ------------------
CC1G_04466_Ccin  KY-PED--NVQ------NTY-G-------------------L------------------
CC1G_01089_Ccin  RQ-PLPNPQDVPGLKVVYPP-S-------------------H------------------
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    DY-KEE--VL--------RI----------------------------------------
AqueK015_Aque    RY-P--------------------------------------------------------
PKA-1_Smoe       ------------------------------------------------------------
PKA-2_Smoe       ------------------------------------------------------------
GK005_Glam       DY-LDE--NGN------FEE-DEIDYENLGSDAAELGLAEIP------------------
GK006_Glam       KSFTEL--DFD------FSS-E-------PLYK--------R------------------


PRKY_Hsap        ----------------------GR------------------------------------
PRKX_Hsap        -------------PVPQKDLEIFK------------------------------------
PKACg_Hsap       -------------SINEKCAKEFS------------------------------------
PKACb_Hsap       -------------SITEKCAKEFG------------------------------------
PKACa_Hsap       -------------SINEKCGKEFS------------------------------------
Pka-C1_Dmel      -------------SSTEKCAKEFA------------------------------------
Pka-C2_Dmel      -------------SRINRHPELFA------------------------------------
CG12069_Dmel     -------------AKTMRHEEAFA------------------------------------
PKA-C3_Dmel      -------------AVDQRDLQYFN------------------------------------
PRKX_Mmus        -------------SVSDKDLETFK------------------------------------
PKACb_Mmus       -------------SITEKCGKEFC------------------------------------
PKACa_Mmus       -------------SINEKCGKEFT------------------------------------
kin-1_Cele       -------------AATPQLEELFV------------------------------------
F47F2.1_Cele     --------------CSQRDRDLFA------------------------------------
TPK1_Scer        -------------QGEDPYADLFR------------------------------------
TPK2_Scer        -------------QGDDPYAEYFQ------------------------------------
TPK3_Scer        -------------QGEDPYMDLMK------------------------------------
DDB0185224_Ddis  NNNNNNNNFNEACTSNTCGGTTAS------------------------------------
pk4_Ddis         -------------LLERRKNEFFS------------------------------------
PKA_Ddis         -------------NYVDPYAHLFK------------------------------------
17649_Tthe       -------------SLPRDLQHLFE------------------------------------
18333_Tthe       -------------NPTKEIQKLFA------------------------------------
2171_Tthe        ---------------IKPADDPFI------------------------------------
26485_Tthe       ---------------LKPADDPFL------------------------------------
PRKX_Spur        -------------PVKSDVLKLFK------------------------------------
PKA_Spur         -------------SLTEKCVKEFA------------------------------------
CC1G_05183_Ccin  -------------PRFDPINYHFL------------------------------------
CC1G_04466_Ccin  -------------PALDPYGVVFPDF----------------------------------
CC1G_01089_Ccin  -------------ILHDNRFPPKL------------------------------------
AqueK013_Aque    ------------------------------------------------------------
AqueK014_Aque    -------------AAAEKFPKEFA------------------------------------
AqueK015_Aque    -----------------------E------------------------------------
PKA-1_Smoe       -----------------------F------------------------------------
PKA-2_Smoe       -----------------------F------------------------------------
GK005_Glam       -------------GTQEEIDALFV------------------------------------
GK006_Glam       -------------EHNADDDQIFQDFCKAYATNAEDEQKTNCPTDNDESNTFTQSGQINY


PRKY_Hsap        --------------------------MM
PRKX_Hsap        --------------------------NF
PKACg_Hsap       --------------------------EF
PKACb_Hsap       --------------------------EF
PKACa_Hsap       --------------------------EF
Pka-C1_Dmel      --------------------------EF
Pka-C2_Dmel      --------------------------NF
CG12069_Dmel     --------------------------DF
PKA-C3_Dmel      --------------------------DF
PRKX_Mmus        --------------------------NF
PKACb_Mmus       --------------------------EF
PKACa_Mmus       --------------------------EF
kin-1_Cele       --------------------------EF
F47F2.1_Cele     --------------------------EW
TPK1_Scer        --------------------------DF
TPK2_Scer        --------------------------DF
TPK3_Scer        --------------------------EF
DDB0185224_Ddis  --------------------------IF
pk4_Ddis         --------------------------NF
PKA_Ddis         --------------------------DF
17649_Tthe       --------------------------DF
18333_Tthe       --------------------------DF
2171_Tthe        --------------------------NW
26485_Tthe       --------------------------DW
PRKX_Spur        --------------------------DF
PKA_Spur         --------------------------DF
CC1G_05183_Ccin  --------------------------EF
CC1G_04466_Ccin  -----------------------EYTGS
CC1G_01089_Ccin  --------------------------DL
AqueK013_Aque    ---------------------------K
AqueK014_Aque    --------------------------DF
AqueK015_Aque    --------------------------DG
PKA-1_Smoe       --------------------------LI
PKA-2_Smoe       --------------------------LI
GK005_Glam       -------------------------GFK
GK006_Glam       DSADAQDSTKGLPACLVDDDDTDMPPPP