Protein (view, download) , Domain (view, download)
PKD3_Hsap       MSANNS--PPSA--QKSV-----LPTA-IPAVLPA-------------------------
PKD2_Hsap       MATAPSY--PA--------------------GLPGS------------------------
PKD1_Hsap       MSAPPVLRPPSP--LLPVAAA--AAAA-AAALVPGS------------------------
CG7125_Dmel     MEGP--------------------------------------------------------
PKD3_Mmus       MSANNS--PPSA--QKSV-----FPAT-VSAVLPA-------------------------
PKD2_Mmus       MAAAPSH--PA--------------------GLPGS------------------------
PKD1_Mmus       MSVPPLLRPPSP--LLPAAAA--VAAA-AAALVPGS------------------------
T25E12.4_Cele   MDANDY--PRLYYTSMPSSSTSMVTTTRFSTSFSPSIPCHRQENFRRHSTSALAKRNGSE
W09C5.5_Cele    MDGSQG------------------------------------------------------
PKD_Spur        MGEEL---PP--------------------------------------------------
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       ------------------------------------------------------------
PKD2_Hsap       ------------------------------------------------------------
PKD1_Hsap       ------------------------------------------------------------
CG7125_Dmel     ------------------------------------------------------------
PKD3_Mmus       ------------------------------------------------------------
PKD2_Mmus       ------------------------------------------------------------
PKD1_Mmus       ------------------------------------------------------------
T25E12.4_Cele   SEKSAEIRENPDEIEVSRVSGRDSSLAFYTTAHETSSMLSRDSRDETLTPNEHIHQASSR
W09C5.5_Cele    ------------------------------------------------------------
PKD_Spur        ------------------------------------------------------------
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       --------------------------------------------------ASPCSSPKTG
PKD2_Hsap       --------------------------------------------------PGPGSPPPPG
PKD1_Hsap       ---------------------------------------------------GPG------
CG7125_Dmel     ------------------------------------------------------------
PKD3_Mmus       --------------------------------------------------PSPCSSPKTG
PKD2_Mmus       --------------------------------------------------PGPGSPPPPG
PKD1_Mmus       ---------------------------------------------------GP-------
T25E12.4_Cele   RVSANDSVFEDGYVDFVDEPREHGSRRKSFEKFTDRNGEEKEGRVFELSTPQPTREAAPG
W09C5.5_Cele    ------------------------------------------------------------
PKD_Spur        ------------------------------------------------------------
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       LSARLSNGSFSAPSLTNSR----------------------------GSVHTVSFLLQIG
PKD2_Hsap       GL-EL---QSPPPLLPQIP----------------------------APGSGVSFHIQIG
PKD1_Hsap       ----------PAPFLAPVA----------------------------APVGGISFHLQIG
CG7125_Dmel     ---------------------------------------------------EVTFLFQFG
PKD3_Mmus       LSARLSNGSFSAPSLTNSR----------------------------GSVHTVSFLLQIG
PKD2_Mmus       GL-DL---QSPPPLLPQIP----------------------------APGSGVSFHIQIG
PKD1_Mmus       -----------APFPAPGA----------------------------APAGGISFHLQIG
T25E12.4_Cele   AH-QF---QLPTLLVTSTPTTVFDHSDDEVWTPYRPPPNREYSSSSEPMMGDLTFRLQSG
W09C5.5_Cele    -----------------------------------------------STDYGDHVVLRYG
PKD_Spur        -----------LPPM-TRP----------------------------GLVHGVSFAVQIG
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       LTRESVTIEAQ---ELSLSAVKDLVCSIVYQKFPECGFFGMYD-KILLFRHDMNSENILQ
PKD2_Hsap       LTREFVLLPAAS----ELAHVKQLACSIVDQKFPECGFYGLYD-KILLFKHDPTSANLLQ
PKD1_Hsap       LSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYD-KILLFRHDPTSENILQ
CG7125_Dmel     SVRDAVCVPAN---SLTLKTLKDLACDFINTKIPDSGLTYLSE-RILLFVHDYSTPNVLH
PKD3_Mmus       LTRESVTIEAQ---ELSLSAVKDLVCSIVYQKFPECGFFGMYD-KILLFRHDMNSENILQ
PKD2_Mmus       LTREFVLLPAAS----ELAHVKQLACSIVDQKFPECGFYGLYD-KILLFKHDPTSANLLQ
PKD1_Mmus       LSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGLYD-KILLFRHDPASDNILQ
T25E12.4_Cele   IHKKSIAVEGT---EIALRDLRNEALQFIKEIYPEKGCSSLED-YILLYKHDLRSINILQ
W09C5.5_Cele    GTREMVPLIRH---EQMLDMLMERARQIV------QGFGNLDTRNMYLFRHEYNSPTLLY
PKD_Spur        FVRENFQIPPE-GGDPSIPLIKEIVTSMVRQRFPEHDFYGVYD-KLLLFKHNPGTSYSLT
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       LITSADEIHEGDLVEVVLSA----------------------------------------
PKD2_Hsap       LVRSSGDIQEGDLVEVVLSA----------------------------------------
PKD1_Hsap       LVKAASDIQEGDLIEVVLSA----------------------------------------
CG7125_Dmel     IINSAAEVVDETLVEIVLTA----------------------------------------
PKD3_Mmus       LITSADEIHEGDLVEVVLSA----------------------------------------
PKD2_Mmus       LVRSAADIQEGDLVEVVLSA----------------------------------------
PKD1_Mmus       LVKIASDIQEGDLIEVVLSA----------------------------------------
T25E12.4_Cele   LITTSSDVTDGTLVEVVIGS----------------------------------------
W09C5.5_Cele    PITSASQITSGSILEIILVD----------------------------------------
PKD_Spur        PVTSVSDVTEGALIEAVLSDQWDGSRMNDLVSQNPSSGKYIYLVKKYDFYCRLLTSLFFS
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       --------------LA----TVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKC
PKD2_Hsap       --------------SA----TFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKC
PKD1_Hsap       --------------SA----TFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKC
CG7125_Dmel     --------------SPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQGLKC
PKD3_Mmus       --------------LA----TVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKC
PKD2_Mmus       --------------SA----TFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKC
PKD1_Mmus       --------------SA----TFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKC
T25E12.4_Cele   --------------CP----QNERIVVHPHTLFVHSYKVPTFCDFCGELLFGLVKQGLKC
W09C5.5_Cele    --------------R-------TEAAVIPHVVEPESYMRPTFCDFCGEMLTGLMRQGVKC
PKD_Spur        TIMNSNAGLQFCFSSA----TVEDRQIRPHTLYVHSYKSPTFCDFCGQMLFGLVRQGLKC
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       EGCGLNYHKRCAFKIPNNCSGVRKRRL-SNVSLPGPGLSV---------PR-------PL
PKD2_Hsap       DGCGLNYHKRCAFSIPNNCSGARKRRL-SSTSLASGH-SVRLGTSESLPCTAEE-LSRST
PKD1_Hsap       EGCGLNYHKRCAFKIPNNCSGVRRRRL-SNVSLTGVS-TIRTSSAELSTSAPDEPLLSPV
CG7125_Dmel     DGCGQNYHKRCVVKIPNNCNRSNDATSRRSFTLQAPR-SPSGSSQQSLVSTEDST-GR--
PKD3_Mmus       EGCGLNYHKRCAFKIPNNCSGVRKRRL-SNVSLPGPGLSV---------PR-------PL
PKD2_Mmus       DGCGLNYHKRCAFSIPNNCSGARKRRL-SSTSLASGH-SVRLGSSESLPCTAEE-LSRST
PKD1_Mmus       EGCGLNYHKRCAFKIPNNCSGVRRRRL-SNVSLTGLG-TVRTASAEFSTSVPDEPLLSPV
T25E12.4_Cele   FGCGLNYHKRCASKIPNNCNGSKQRRP-SAIPLSPSN-SNILNLNERRHSRRES-C----
W09C5.5_Cele    KNCNGNFHKRCSNAARNNCGAPGAPGAQ------------------------------PS
PKD_Spur        DGCGGNYHKRCAFKIPNDCTLSKRRRS--SLAISS--SSIPWSPSETSLSSEDSQ-QQQQ
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       QP-----EYVALPSEES-----------------------HVHQEPSKRIPSWSGRPIWM
PKD2_Hsap       TE-----LLPRRPPSSS----------------------------SSSSASSYTGRPIEL
PKD1_Hsap       SP-----GFEQKSPSES-----------------------FIGREKRSNSQSYIGRPIHL
CG7125_Dmel     ---------NDSSSSLN-----------------------IPGRHQRTHSS--G------
PKD3_Mmus       QP-----ECVPLLSEES-----------------------HTHQEPSKRIPSWSGRPIWM
PKD2_Mmus       TD-----LLPRRPPSSS---------------------------SSSSSSSFYTGRPIEL
PKD1_Mmus       SP-----GFEQKSPSES-----------------------FIGREKRSNSQSYIGRPIQL
T25E12.4_Cele   LE-----ALDAARPSSTLGGAATPNIFITSDDCGDAVGGNYLQMPRKDRSCSWSGRPLWM
W09C5.5_Cele    RP-----PILPPIP------------------------------------TTPTGFPV--
PKD_Spur        QQLAVFVTHSQQTPLVK------------------------SDSYKERRSPSWGNRPLWV
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       EKMVMCR--VKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVP
PKD2_Hsap       DKMLLSK--VKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVP
PKD1_Hsap       DKILMSK--VKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVP
CG7125_Dmel     SRNGLMV--LRIPHTFMVHTYGIPTVCQLCKKLLKGLFKQGLQCRDCQYNTHKKCMDKVP
PKD3_Mmus       EKMVMCR--VKVPHTFAVHSYGRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVP
PKD2_Mmus       DKMLMSK--VKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVP
PKD1_Mmus       DKLLMSK--VKVPHTFVIHSYTRPTVCQFCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVP
T25E12.4_Cele   EIAEATRVKLQVPHTFQVHSYKLPTVCQHCKKLLKGLIRQGMQCRDCKYNCHKKCSEHVA
W09C5.5_Cele    -AALSTP--TGLPHTLIEHSYRQFTVCKVCDHLLVGLVKQGLKCRDCGVNVHRKCAMELA
PKD_Spur        ERAVASR--IKVPHTFVVHNYTKPTICQYCKRLLVGLFRQGLQCKDCKFNCHKRCADKVP
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       RDCLG-EVTFNGEPSSLGT-DTDIPMDIDNNDINSDS-SR----G-LDDTEEPSPPEDKM
PKD2_Hsap       NDCLG-EALING----------DVPMEEATDFSEADK-SA-----LMDESEDSGVIPGS-
PKD1_Hsap       NNCLG-EVTINGDLLSPGA-ESDVVMEEGSDDNDSER-NS----GLMDDMEEAMVQDAEM
CG7125_Dmel     HDCTG-EAQLSQLQIQAGAKERDNFFREEFDDSDGDD-GSEEAPKALTNAHNSPPELVNG
PKD3_Mmus       RDCLG-EVTFNGEPCSVGT-DADMPMDIDSSDVNSDG-SR----G-LDDSEEPSPPEDKM
PKD2_Mmus       NDCLG-EALING----------DVPMEEAADYSEADK-SS-----ISDELEDSGVIPGS-
PKD1_Mmus       NNCLG-EVTINGELLSPGA-ESDVVMEEGSDDNDSER-NS----GLMDDMDEAMVQDTEM
T25E12.4_Cele   KDCSG-NTKASQFF--LGS-QADDGASEDRDDDLSLRSGS----GAHKKAQN-T----PS
W09C5.5_Cele    SNCVLSENAISR------------------------------------------------
PKD_Spur        KDCLG-ETPLQE-----GD-NDDQERLIESDENEAEE-NE----------------NGS-
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       F------------FLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMV
PKD2_Hsap       --------------HSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTL
PKD1_Hsap       AMAECQN---D--SGEMQDP-DPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVM
CG7125_Dmel     GLVDDSS--VSGGETSKSSS-DGQSEQSQSSTSSSPSANIPLMRIVQSVKHTKKRGGQAL
PKD3_Mmus       F------------FLDPTDLDVERDEETVKTISPSTSNNIPLMRVVQSIKHTKRRSSTVV
PKD2_Mmus       --------------HSESALHASEEEEGEGHKAQSSLGYIPLMRVVQSVRHTTRKSSTTL
PKD1_Mmus       ALAEGQS---G--GAEMQDP-DADQEDSNRTISPSTSNNIPLMRVVQSVKHTKRRSSTVM
T25E12.4_Cele   APLQGSEGSGSPGPVVSFAANA-LSNMPDDDVISSESANIPLMRVVMSKKQTKRKNNKLL
W09C5.5_Cele    ----------------------VNFTDPEG-PGSSSSDNIPLFRLPGQVG--TRATEKKK
PKD_Spur        -NRD------S--IGDETL---PDSPVNENPLSPVQSNNIPLMRIVQSVKHTKRRGSQVL
AqueK080_Aque   ------------------------------------------------------------


PKD3_Hsap       KEGWMVHYTSRDNL-RKRHYWRLDSKCLTLFQNES------GSKYYKEIPLSEILRISSP
PKD2_Hsap       REGWVVHYSNKDTL-RKRHYWRLDCKCITLFQNNT------TNRYYKEIPLSEILTVESA
PKD1_Hsap       KEGWMVHYTSKDTL-RKRHYWRLDSKCITLFQNDT------GSRYYKEIPLSEILSLEPV
CG7125_Dmel     KEGWLVHYTSLDKA-VKRYYWRLDSKTITLFVSEQ------GSKYHKELPLAELLSIESH
PKD3_Mmus       KEGWMVHYTSRDNL-RKRHYWRLDSKCLTLFQNES------GSKYYKEIPLSEILRVSSP
PKD2_Mmus       REGWVVHYSNKDTL-RKRHYWRLDCKCITLFQNNT------TNRYYKEIPLSEILAVEPA
PKD1_Mmus       KEGWMVHYTSKDTL-RKRHYWRLDSKCITLFQNDT------GSRYYKEIPLSEILCLEPA
T25E12.4_Cele   KEGWIVHYTDQQNM-RKKHYWRLDTKGITMYQDEN------TTRYYKEIPLNEILNVSMS
W09C5.5_Cele    LEGWMMHFILSDPERRLKHYWMMQSNAIHLYNEYSEGIGVNPNRVYRIIPLAEITSVVQN
PKD_Spur        KEGWMVHYTDKDSM-RKRHYWRIDTKAITLYQSES------STRYYKEIPLSEILSVRMV
AqueK080_Aque   ---------------RKKHFWRLDTKTLTLYKDSE------SSHYYKEIQLADIMAVDPM
                                 :::* :: : : :: .         .: :: : * ::  :

PKD3_Hsap       RDFTNIS------------------QGSNPHCFEIITD-TMVYFVGENNGDSSHNP----
PKD2_Hsap       QNFSLVP------------------PGTNPHCFEIVTA-NATYFVGEMPGGTPG------
PKD1_Hsap       KTSALIP------------------NGANPHCFEITTA-NVVYYVGENVVNPSSPSPN--
CG7125_Dmel     LG---DP------------------RPECNYCFELRLP-NLSYFVGQDPQVGAKEEQA--
PKD3_Mmus       QDFTSIS------------------QGSNPHCFEIITD-TVVYFVGENNGSSSHNP----
PKD2_Mmus       QNFSLVP------------------PGTNPHCFEIITA-NVTYFVGETPGGAPG------
PKD1_Mmus       KPSALTP------------------VGATPHCFEITTA-NVVYYVGENVVNPSSSPPN--
T25E12.4_Cele   P-----P------------------DKTADYLFEIRTG-VCVYFISGSPSD---------
W09C5.5_Cele    NGKSV-L------------------AKHPPHCFEIRTTTNTVFCVGEDYHAFSGGPPK--
PKD_Spur        KPSQDGSGSGSSSSGMGISGLVGGDGFNSTHCFEIQTA-KTNYYVGERASLGDSSSEKGS
AqueK080_Aque   VNHALYP-------------------LSPPHVFEIVTS-SCTYYVGVDMAGAVPEDLNPP
                                              : **:       : :.

PKD3_Hsap       -----------------------VL-AATGVGLDVAQSWEKAIRQALMPVTPQASVCTSP
PKD2_Hsap       --------------------------GPSGQGAEAARGWETAIRQALMPVILQDAP-SAP
PKD1_Hsap       ----------------------NSV-LTSGVGADVARMWEIAIQHALMPVIPKGSS-VGT
CG7125_Dmel     --------------------VRLPP-PDSGIGSDIAKSWETSIRQAFMHVTNTQC-----
PKD3_Mmus       -----------------------VL-AATGVGLDVAQSWEKAIRQALMPVTPQASVCTSP
PKD2_Mmus       --------------------------GPSGQGTEAVRGWETAIRQALMPVILQDAP-SAP
PKD1_Mmus       ----------------------NSV-LPSGIGPDVARMWEVAIQHALMPVIPKGSS-VGS
T25E12.4_Cele   ---------------------------EKGSSLD-AQSWTTAIQSALMPVTPQSSVV-GG
W09C5.5_Cele    ----------------------KIPRSMSVRPSSNTTMWFQFIKESLQPPSR--------
PKD_Spur        G---GSTTSSSKLPVPSSSSVDEEP-EQSWVGADVARDWEQKIRQALMPVTPQQSGTSIT
AqueK080_Aque   KQTEGALG--PNILCNVSHMSLNQL-EEIGVGLTVALSWEEGLHSALMPITPQASMGSLA
                                                   .  *   :: ::

PKD3_Hsap       GQG------------KDHKD----------------------------------------
PKD2_Hsap       GH-------------APHRQ----------------------------------------
PKD1_Hsap       GT-------------NLHRD----------------------------------------
CG7125_Dmel     ------------------------------------------------------------
PKD3_Mmus       GQG------------KDHKD----------------------------------------
PKD2_Mmus       GH-------------TPHRQ----------------------------------------
PKD1_Mmus       GS-------------NSHKD----------------------------------------
T25E12.4_Cele   -KR------------IDKLK----------------------------------------
W09C5.5_Cele    ------------------------------------------------------------
PKD_Spur        STS------------SPRNDSVIQIP-RG---------YNPHHRQERKEGPVNATENGDD
AqueK080_Aque   DIGVPGAAIVRPSSFRGRRGSSLKGSFRGTKGSFRNASRPPHHTSTGRGSFRGSFRAVKQ


PKD3_Hsap       LSTSIS---VSNCQIQEN-VDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVID
PKD2_Hsap       ASLSIS---VSNSQIQEN-VDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVID
PKD1_Hsap       ISVSIS---VSNCQIQEN-VDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIID
CG7125_Dmel     ------------CESEEQVQDMGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVID
PKD3_Mmus       LATSIS---VSNCQVQEN-VDISSVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVID
PKD2_Mmus       ASLSIS---VSNSQIQEN-VDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVID
PKD1_Mmus       ISVSIS---VSNCQIQEN-VDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIID
T25E12.4_Cele   VPTEGE-TGHLGAKIQTE-HEFSQLYQIFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLID
W09C5.5_Cele    ----------NEDNAEQA-LEFANLYQVLSDKTLGSGQFGTVYSAIQRHSGKEVAVKVIS
PKD_Spur        FPAKVS--EPSFLNKREN-NDISQHYQIFPDEILGSGQFGIVYGGVHRTSGRQVAIKVID
AqueK080_Aque   SPPAIPVRAAMKPKIETK-MDVSQMYQIFPEEILGSGQFGTVFGGQNRTTGKSVAIKVID
                             : .    :..  **::.:: ******* *:.. :: . : **:*:*.

PKD3_Hsap       KMRFPTKQE--SQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSS
PKD2_Hsap       KLRFPTKQE--SQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSS
PKD1_Hsap       KLRFPTKQE--SQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSS
CG7125_Dmel     KLRFPTKQE--AQLKNEVAILQNISHCGVVNLERMFETPERIFVVMEKLKGDMLEMILSH
PKD3_Mmus       KMRFPTKQE--SQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSS
PKD2_Mmus       KLRFPTKQE--SQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSS
PKD1_Mmus       KLRFPTKQE--SQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSS
T25E12.4_Cele   KLKFPPNKE--DLLRAEVQILEKVDHPGVVHFMQMLETTDRIFVVMEKLKGDMLEMILSS
W09C5.5_Cele    KERFSKKGSGAESMRAEVAILQQTCHPGIVCLEFMCETKDKIFVVMEKMNGDMLEMILSQ
PKD_Spur        KFRFPTKQE--TQLKNEVAILHKVRHPGVVNLEQMFETPERVFVVMEKLKGDMLEMILSS
AqueK080_Aque   KLRFPHKQD--TALRQEVTILQFLDHPGIIYLEQMFETPEKIYIAMEKMNGDMLEMILSS
                * :*. : .    :: ** **.   * *:: :  * ** :::::.***::*********

PKD3_Hsap       EKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLAS-AEPFPQVKLCDFGFAR
PKD2_Hsap       EKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR
PKD1_Hsap       EKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR
CG7125_Dmel     ARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSS-DAEFPQVKLCDFGYAR
PKD3_Mmus       EKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLAS-AEPFPQVKLCDFGFAR
PKD2_Mmus       EKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR
PKD1_Mmus       EKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR
T25E12.4_Cele   EKGRLSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNS-NSDFPQVKLCDFGFAR
W09C5.5_Cele    ELGRLNSRATKFLLVQILCALKYLHDQGIAHCDLKPENVLLSDMGSNFPQTKICDFGYAR
PKD_Spur        VHGRLFERVTRFLISQILIALKYLHSKSIVHCDLKPENVLLSS-DGDFPQVKLCDFGFAR
AqueK080_Aque   PNSRLSERVTKFLVYQILAALQYLHKKDIVHCDLKPENVLLTS-ESGMPQVKLCDFGFAR
                  .** .: *:*:: *** **: **  .*.********:** .    :**.*:****:**

PKD3_Hsap       IIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQ
PKD2_Hsap       IIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQ
PKD1_Hsap       IIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQ
CG7125_Dmel     IIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEEEDINDQ
PKD3_Mmus       IIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQ
PKD2_Mmus       IIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQ
PKD1_Mmus       IIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQ
T25E12.4_Cele   IIGEKSFRRSVVGTPAYLAPEVLRNKGFNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQ
W09C5.5_Cele    FIPESQFRKTVVGTPAYLPPEVLQRKGYNKSLDMWSVGVIIYVTLSGTFPFNEGEEISEQ
PKD_Spur        IIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFPFNEDEEITDQ
AqueK080_Aque   IIGEKSFRKSIVGTPAYLAPEVLKNEGYNRSLDLWSVGVIIYVSLSGTFPFNEDEEISDQ
                :* *..**:::*******.****  :*:*:***:******:**:********* *:* :*

PKD3_Hsap       IQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFE
PKD2_Hsap       IQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELE
PKD1_Hsap       IQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELE
CG7125_Dmel     IQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWLQDKQTYRDLRNLE
PKD3_Mmus       IQNAAFMYPPNPWREISSEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFE
PKD2_Mmus       IQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELE
PKD1_Mmus       IQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELE
T25E12.4_Cele   IQNAEFMYPPTPWKEISENAIEFINGLLQVKMSKRYTVTKAQSQIWMQNYTLWSDLRVLE
W09C5.5_Cele    IQNASFMFPTEPWSEVEPLAVDLIQKLLKVEIEARMSIEQCLDHGWLKGEQLYRDLRDLE
PKD_Spur        IHNAAFMFPPNPWNEISEGAIDLIRNLLQVKIRKRYTADKSLAHPWLQDYQVWLDLRDLE
AqueK080_Aque   IHNAAFMYPPDPWAAITQEAIDLVSKLLQINRRSRFKTTQALNHIWLRDIRLYEDVCELE
                *:** **:*. **  :   *::::  **:::   * .  :   : *::    : *:  :*

PKD3_Hsap       TRIGE-RYITHESDDARWEIHAYT-HNLV----YPK------------------------
PKD2_Hsap       GKMGE-RYITHESDDVRWEQFAAE-HPLP----G--------------------------
PKD1_Hsap       CKIGE-RYITHESDDLRWEKYAGE-QGLQ----YPT------------------------
CG7125_Dmel     AQVGAGRYLTHEADDLRW------------------------------------------
PKD3_Mmus       TRIGE-RYITHESDDARWEIHAYT-HNLE----YPK------------------------
PKD2_Mmus       GKMGE-RYITHESDDARWDQFVAE-RH---------------------------------
PKD1_Mmus       CRIGE-RYITHESDDSRWEQYAGE-QGLQ----YPA------------------------
T25E12.4_Cele   KAVGQ-RFVTHESDDQQDPQRNFS-YFLHLLVTYPFKFYF---VFSCFII-FF-------
W09C5.5_Cele    VRLNTPRYLTSPQDDILYGTLV--------------------------------------
PKD_Spur        TIVGS-RYLTHESDDERWSAYQQA-QLGA-------------------------------
AqueK080_Aque   GRLDI-RYLTHETEDAWWAQQGAKPHPLV----LKKEKKFSHHVYKNIQILDDPHRSNVP
                  :.  *::*   :*

PKD3_Hsap       -----------------------HFI--M---------APNPDDM---------------
PKD2_Hsap       -----------------------SGL--P--TDRDLGGACPPQDHD--------------
PKD1_Hsap       -----------------------HLI--N--PSASHSDTPETEETE--------------
CG7125_Dmel     ------------------------------------------------------------
PKD3_Mmus       -----------------------HFI--M---------APNPDDM---------------
PKD2_Mmus       ------------------------GT--P--AEGDLGGACLPQDHE--------------
PKD1_Mmus       -----------------------HLI--S--LSASHSDSPEAEERE--------------
T25E12.4_Cele   ---------------------------PN--FLTHIPCVP--------------------
W09C5.5_Cele    ------------------------------------------------------------
PKD_Spur        -------------------------G--N--DPAPGGNSPDNNSTH--------------
AqueK080_Aque   SIATTVAVAKPPPPPSSNPPPSSTLVNPGPPAPTNNRSSKDKDSTDLKAGRKEKEGVAIK


PKD3_Hsap       --------------EEDP
PKD2_Hsap       ---MQ----GLAERISVL
PKD1_Hsap       ---MK----ALGERVSIL
CG7125_Dmel     -----------------D
PKD3_Mmus       --------------EEDP
PKD2_Mmus       ---MQ----GLAERISIL
PKD1_Mmus       ---MK----ALSERVSIL
T25E12.4_Cele   --------------TPIS
W09C5.5_Cele    ----------------NP
PKD_Spur        ---LQLSPVRHMDRVSTL
AqueK080_Aque   LSDIEAHAKRVGYTVSTV