Protein (view, download) , Domain (view, download)
HSER_Hsap       MKTLLLD----------L------------------------------------------
CG10738_Dmel    MFAHPCPAPAGNYHSGLL--H---------------------------------------
CG9783_Dmel     MLCCWLQ-----------------------------------------------------
Gyc32E_Dmel     MRDYASNVI-RSHRCLCI--F---------------------------------------
Gyc76C_Dmel     MTRWPF------------------------------------------------------
CG4224_Dmel     MLLV--------------------------------------------------------
CG3216_Dmel     MHLL--------------------------------------------------------
KSGC_Mmus       MASRTRS----------E--S--------------------------------------P
HSER_Mmus       MTSLLGL-----------------------------------------------------
CYGX_Mmus       MAGLQQG----------CH-F-------------EGQNWTA-PHWKTCLPCQ-GPWRLTV
CYGF_Mmus       MFLGPWP----------FSRL-------------L--SWFAI-----------------S
CYGD_Mmus       MSAWLLP----------AGG---------------------LPGAGFCVPARQSPSS--F
ANPb_Mmus       MALP--------------------------------------------------------
ANPa_Mmus       MPGSRRV----------R--P---------------------------------------
odr-1_Cele      MCVLRLW----------Q--M---------------------------------------
gcy-9_Cele      MGPSGMI----------R--S---------------------------------------
gcy-8_Cele      MRTKKAF----------L--L---------------------------------------
gcy-7_Cele      MKPFYSM-----------------------------------------------------
gcy-6_Cele      MRSAEPR-----------------------------------------------------
gcy-5_Cele      MRLLYFS-----------------------------------------------------
gcy-4_Cele      MILFSKY-----------------------------------------------------
gcy-3_Cele      MKNVFQL-----------------------------------------------------
gcy-27_Cele     MNKLITV-----------------------------------------------------
gcy-25_Cele     MLLLLL------------------------------------------------------
gcy-23_Cele     MPNAGFW----------S--A---------------------------------------
gcy-22_Cele     MSFISKC-----------------------------------------------------
gcy-21_Cele     MLSAVLL----------L--L---------------------------------------
gcy-20_Cele     MRILLL------------------------------------------------------
gcy-2_Cele      MVSSILK-----------------------------------------------------
gcy-19_Cele     MEYLLFL-----------------------------------------------------
gcy-18_Cele     MLKTLLF----------I--L---------------------------------------
gcy-17_Cele     MINRNK------------------------------------------------------
gcy-15_Cele     MGLMRDC----------Y--I---------------------------------------
gcy-14_Cele     MCLFLL------------------------------------------------------
gcy-13_Cele     MASS--------------------------------------------------------
gcy-12_Cele     MWPTSVE----------A--LRFYHTFAFSPGRRR-------------------------
gcy-11_Cele     MLDIMLA----------D--TKK-------------------------------------
gcy-1_Cele      MQIFTIL-----------------------------------------------------
daf-11_Cele     MGP---------------------------------------------------------
C04H5.4_Cele    MLPNFWN----------F--Q---------------------------------------
CYGF_Hsap       MFLGLGR----------FSRL-------------V--LWFAA-----------------F
ANPb_Hsap       MALP--------------------------------------------------------
ANPa_Hsap       MPGPRRP-------AGSR--L---------------------------------------
CYGD_Hsap       MTACARR----------AGG---------------------LPDPGLCGPAWWAPS---L
T01A4.1_Cele    MIDR--------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       MEKM--------------------------------------------------------
Gcy3_Spur       MLGGSA------------------------------------------------------
Npr3_Spur       MTAI--------------------------------------------------------
Npr4_Spur       MAEDAPN----------D--D---------------------------------------
Gcy1_Spur       MAHARH------------------------------------------------------
Gcy2_Spur       MFQYYK------------------------------------------------------
Npr5_Spur       MSNAMS------------------------------------------------------
AqueK220_Aque   MADSKSL-----------------------------------------------------
AqueK221_Aque   MIFTLL------------------------------------------------------
AqueK222_Aque   MFSSGL------------------------------------------------------


HSER_Hsap       ---------------AL------------WS-LLF-QP----------------------
CG10738_Dmel    -------------PLLL------------LL-FLL-AF----------------------
CG9783_Dmel     ---------------------------------QL-------------------------
Gyc32E_Dmel     -------------TVLQ------------LT-LML-SM----------------------
Gyc76C_Dmel     --------------NL--------------L-LLL-SV----------------------
CG4224_Dmel     -----------------------------LL--LV-GL----------------------
CG3216_Dmel     ---------------GI------------SI-HFF-FL----------------------
KSGC_Mmus       LEPRLYAGAGSRADHPS------------LV-LML-SV----------------------
HSER_Mmus       ---------------AV------------RL-LLF-QP----------------------
CYGX_Mmus       SHLKT---VSSISVLSV------------VFWSVL-LW----------------------
CYGF_Mmus       SRLSGQHGLPSSKFLRC------------LC--LL-AL----------------------
CYGD_Mmus       SRVLR---WPRP-GLPG------------LL--LL-LL----------------------
ANPb_Mmus       ---------------SL------------LL--VV-AA----------------------
ANPa_Mmus       -------------RLRA------------LL--LL-PP----------------------
odr-1_Cele      --------------RRPMDSVQQSQYSEKHL-ELL-TV----------------------
gcy-9_Cele      --------------EWLH----------KTS-HLL-RR----------------------
gcy-8_Cele      --------------L------------------TF-NV----------------------
gcy-7_Cele      ---------------SL------------VL--FL-VI----------------------
gcy-6_Cele      ---------------NE------------KC--IL-NTSDASQTIQDCPLIHFHNSFPVN
gcy-5_Cele      ---------------MV------------LL---W--V----------------------
gcy-4_Cele      ---------------YF------------SM-RQLNYY----------------------
gcy-3_Cele      ---------------LI------------PL---F-FH----------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ---------------------------------LL-KI----------------------
gcy-23_Cele     --------------A------------------YA-EM----------------------
gcy-22_Cele     ---------------FI------------CL--LF-ST----------------------
gcy-21_Cele     ----------------------------------F-FI----------------------
gcy-20_Cele     ---------------------------------LL-QN----------------------
gcy-2_Cele      ---------------FV------------IL---I-HS----------------------
gcy-19_Cele     ---------------L-------------LF---AGFL----------------------
gcy-18_Cele     --------------I------------------FF-NI----------------------
gcy-17_Cele     ---------------------------------IL-------------------------
gcy-15_Cele     ----------------------------------Q-ST----------------------
gcy-14_Cele     ---------------------------------LF-P-----------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     -------------RLFG------------LS-IVF-VI----------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      -----------------------------LL---F--N----------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    --------------F------------------IF-VI----------------------
CYGF_Hsap       RKLLGHHGLASAKFLWC------------LC--LL-SV----------------------
ANPb_Hsap       ---------------SL------------LL--LV-AA----------------------
ANPa_Hsap       -------------RLLL------------LL--LL-PP----------------------
CYGD_Hsap       PRLPR----ALP-RLPL------------LL--LL-LL----------------------
T01A4.1_Cele    ---------------KL------------SI---F-T-----------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ---------------LI------------FT-SLF-SV----------------------
Gcy3_Spur       ----------------P------------L------KA----------------------
Npr3_Spur       ---------------LL------------AL--LL-TG----------------------
Npr4_Spur       ---------------------------------MI-PS----------------------
Gcy1_Spur       --------------LFL------------LL-VAF-TI----------------------
Gcy2_Spur       ----------------L-------------------------------------------
Npr5_Spur       --------------KQS------------LL-----------------------------
AqueK220_Aque   ---------------PF------------SL--FF-AA----------------------
AqueK221_Aque   ---------------NL------------LL--FF-SA----------------------
AqueK222_Aque   --------------CY--------------H-QIG-DN----------------------


HSER_Hsap       ----------G-W-L-----S----F------S-S--Q----------------------
CG10738_Dmel    ----------S-N------------F---R------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ----------L-E-V-----Q----I---Q--I-D--Q----------------------
Gyc76C_Dmel     ----------A-V-R-----D---------------------------------------
CG4224_Dmel     ------------V-F-----G----PKDCV------------------------------
CG3216_Dmel     ----------M-Y-V-----N----C---F----S--A----------------------
KSGC_Mmus       ----------V-M-L-----V----T---C--L-E-------------------------
HSER_Mmus       ----------A-L-M-----V----F---W--A-S--Q----------------------
CYGX_Mmus       ------------A-D-----S--------L----S--L----------------------
CYGF_Mmus       ------------L-P-----L--------L------------------------------
CYGD_Mmus       ------------L-P-----S--------P------------------------------
ANPb_Mmus       ------------L-A-----G----G---V------------------------------
ANPa_Mmus       ------------L-L-----L--------L------------------------------
odr-1_Cele      ----------I-I-L-----LKLFG-------V--------------FH-----------
gcy-9_Cele      ----------F-I-NPTTPNFLHFTST--YIGI-R--S------INTFL-----------
gcy-8_Cele      ----------L-I-Y-----L----AA-----C-Q--E------TERIL-----------
gcy-7_Cele      ----------T-L-L-----P----KP----------M--------------------F-
gcy-6_Cele      DRSLSTFCNFSFI-I-----C----DP----------G----------TRNFKLASVRFL
gcy-5_Cele      ----------L-G------------AS--E------------------------------
gcy-4_Cele      ----------I-F-I-----S----TI--L--T-Y--N--------------------L-
gcy-3_Cele      ----------L-F-------S----LV--S--L-Q--N--------------------I-
gcy-27_Cele     --------------------IRDFS-----------------------------------
gcy-25_Cele     ----------S-T-F-----V---------------------------------------
gcy-23_Cele     ----------P-ISK-----F----TA-----Y-A--E-------NAVM-----------
gcy-22_Cele     ----------Y-F-L-----P---------------------------------------
gcy-21_Cele     ----------Q-N-V-----Q--------N--F-D--K----------------------
gcy-20_Cele     ----------I-L-V-----F---------------------------------------
gcy-2_Cele      ----------T-F-------H----ST--F--A-Q--N--------------------L-
gcy-19_Cele     ----------T-F-L-----P----RF--L--IYA--Q--------------------I-
gcy-18_Cele     ----------P-I-------I----A------I-E--E------IPDI------------
gcy-17_Cele     --------------A-----N---------------------------------------
gcy-15_Cele     --------------I-----L---------------------------------------
gcy-14_Cele     ----------Y-L-A-----S---------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ----------A-A-L-----C----VT--S--C-D--A----------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ----------I-F-------P----SI--F--V-Q--N--------------------L-
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ----------F-C-W-----I----PI-----V-V--S------D---------------
CYGF_Hsap       ------------M-S-----L--------P------------------------------
ANPb_Hsap       ------------L-A-----G----G---V------------------------------
ANPa_Hsap       ------------L-L-----L----L---L------------------------------
CYGD_Hsap       ------------L-Q--------------P------------------------------
T01A4.1_Cele    ----------R--------------K---K----S--T----------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ----------I-I-I-----V----L---I----S--G----------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ----------P------------------P----H--N----------------------
Npr4_Spur       ----------H---T-------------------D-------------------------
Gcy1_Spur       ----------T-M-V-----I----A---R--L-D--F----------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ----------F-F-I-----A----AV--Q--A-RTYRIPSYLTC---------------
AqueK221_Aque   ----------C-K-A-----A---------------CTIPCYLTC---------------
AqueK222_Aque   ----------V-L-F-----H---------------------------------------


HSER_Hsap       --------------------V---------------------------------------
CG10738_Dmel    -------------PT---------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------SPE---------------------------------------------
Gyc76C_Dmel     ------------------------------------------------------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------HPNPRRNDITWDDLNKDISLDSTTSLAGLNASDAGLEQRMYERSRESK
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       --------------------V---------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ---R--------------------------------------------------------
gcy-8_Cele      ---A--------------------------------------------------------
gcy-7_Cele      ---PQ----V--------------------------------------------------
gcy-6_Cele      KYDIQ----T--------------------------------------------------
gcy-5_Cele      ---------CQ-------------------------------------------------
gcy-4_Cele      ---T--------------------------------------------------------
gcy-3_Cele      ---PV-------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ---P--------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ----------IEL-----------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ---PD----TT-------------------------------------------------
gcy-19_Cele     ---TSSTTTTTPVPA---------------------------------------------
gcy-18_Cele     ---K--------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ----------DAVPA---------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ---PD----TT-------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------PPSES-------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       --------------------I---------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------NPT-----I---------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   -------------PG---------------------------------------------
AqueK221_Aque   -------------PG---------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------S--------------------------------------Q--------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     ------------------------------------------------------------
CG4224_Dmel     ------------A-----------------------------------------------
CG3216_Dmel     STQLSRYTEVGEM-----------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------R--------------------------------------Q--------
CYGX_Mmus       ------------L-----------------------------------------------
CYGF_Mmus       ------------R-----------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------R-----------------------------------------------
ANPa_Mmus       ------------R-----------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------R--------------------------------------DCSNRS---
gcy-8_Cele      ------------N--------------------------------------NGTEDNEIT
gcy-7_Cele      ---------------------------------------------------A--------
gcy-6_Cele      ---------------------------------------------------I--------
gcy-5_Cele      ---------------------------------------------------V--------
gcy-4_Cele      ---------------------------------------------------H--------
gcy-3_Cele      ---------------------------------------------------S--------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------K--------------------------------------NSECRTGIS
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------E-----------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ---------------------------------------------------V--------
gcy-19_Cele     ------------A-NRRTVGLRDFFTGPNFFMKIFTAKFEFYVFFLVYSGIF--------
gcy-18_Cele     ------------E--------------------------------------NGEKSSYTQ
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------P-----------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ---------------------------------------------------V--------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------Q-----------------------------------------------
ANPb_Hsap       ------------R-----------------------------------------------
ANPa_Hsap       ------------R-----------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------T-----------------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------I--------------------------------------N--------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------IND------------------------------------T--------
AqueK221_Aque   ------------VNE------------------------------------T--------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ----------------------------------------N--------------C----
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     ---------------------------------------CS--------------N----
CG4224_Dmel     ----------------------------------------TCREEPARDCEAICDA----
CG3216_Dmel     ----------------------------------------G--------------S----
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ----------------------------------------N--------------C----
CYGX_Mmus       ----------------------------------------A--------------W----
CYGF_Mmus       ----------------------------------------W--------------G----
CYGD_Mmus       ----------------------------------------S--------------A----
ANPb_Mmus       ----------------------------------------P--------------P----
ANPa_Mmus       ----------------------------------------S--------------G----
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ----PSP---------------HE-PYYS-----------T--------------R----
gcy-8_Cele      TSKGVSPN--------------TN-PLFLSN--STAGLYDS--------------K----
gcy-7_Cele      ---------------------------------------TG--------------T----
gcy-6_Cele      ---------------------------------------CQ--------------P----
gcy-5_Cele      ---------------------------------------IP--------------S----
gcy-4_Cele      ---------------------------------------GQ--------------G----
gcy-3_Cele      ---------------------------------------TG--------------T----
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     LSIGSYHEISEEGFKIWDNPTGVGPPLRLIAKIYTHFFAFR--------------Y----
gcy-22_Cele     ----------------------------------------P--------------V----
gcy-21_Cele     ----------------------------------------D-----------------IT
gcy-20_Cele     ----------------------------------------C--------------Q----
gcy-2_Cele      ---------------------------------------AP--------------K----
gcy-19_Cele     ---------------------------------------SS--------------K----
gcy-18_Cele     FDNGAKLEV------------------------------NK--------------E----
gcy-17_Cele     ----------------------------------------C--------------Q----
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ----------------------------------------G--------------Q----
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ----------------------------------------SP-------------EAEPS
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ---------------------------------------AP--------------R----
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ----------------------------------------Q--------------V----
ANPb_Hsap       ----------------------------------------P--------------P----
ANPa_Hsap       ----------------------------------------G--------------S----
CYGD_Hsap       ----------------------------------------P--------------A----
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ----------------------------------------T--------------A----
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ----------------------------------------Q--------------T----
Gcy1_Spur       ---------------------------------------ED--------------R----
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ---------------------------------------DA--------------D----
AqueK221_Aque   -------------------------------------------------------G----
AqueK222_Aque   ---------------------------------------CW--------------W----


HSER_Hsap       ---------------------HNG------------------------------------
CG10738_Dmel    ---------------------HGE------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ---------------------LQRPMTRVLLGAQLGELAWSPLFSGFAMGAMFYGYGLIH
Gyc76C_Dmel     ---------------------HRT------------------------------------
CG4224_Dmel     ---------------------NGR------------------------------------
CG3216_Dmel     ---------------------TMR------------------------------------
KSGC_Mmus       ----------------------AA------------------------------------
HSER_Mmus       ---------------------RNG------------------------------------
CYGX_Mmus       ---------------------ARE------------------------------------
CYGF_Mmus       ---------------------QAL------------------------------------
CYGD_Mmus       ---------------------LSA------------------------------------
ANPb_Mmus       ---------------------GAR------------------------------------
ANPa_Mmus       ---------------------HAS------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ---------------------TRC------------------------------------
gcy-8_Cele      ---------------------GRI------------------------------------
gcy-7_Cele      ---------------------TGN------------------------------------
gcy-6_Cele      ---------------------PGN------------------------------------
gcy-5_Cele      ---------------------SRR------------------------------------
gcy-4_Cele      ---------------------PRP------------------------------------
gcy-3_Cele      ---------------------TRP------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     -----------------------D------------------------------------
gcy-23_Cele     ---------------------FQC------------------------------------
gcy-22_Cele     ---------------------NSA------------------------------------
gcy-21_Cele     VY--------------F-------------------------------------------
gcy-20_Cele     ---------------------FLQ------------------------------------
gcy-2_Cele      ---------------------TKR------------------------------------
gcy-19_Cele     ---------------------FEN------------------------------------
gcy-18_Cele     ---------------------HKR------------------------------------
gcy-17_Cele     ---------------------ARR------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ---------------------FLQ------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     LGAGANPYLLDSLVKRLPKKGDKK------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ---------------------TKR------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ---------------------EKI------------------------------------
CYGF_Hsap       ---------------------WTL------------------------------------
ANPb_Hsap       ---------------------GAR------------------------------------
ANPa_Hsap       ---------------------HAG------------------------------------
CYGD_Hsap       ---------------------LSA------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ---------------------GFS------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ---------------------KNR------------------------------------
Gcy1_Spur       ---------------------GRT------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ---------------------AKP------------------------------------
AqueK221_Aque   ---------------------SKL------------------------------------
AqueK222_Aque   ---------------------GN-------------------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     LPSKGPLGCFFSRLRTAGLSVWQQCSPVMLVPWTLKVAQGLSLFPCHLWEFLANEVCLET
Gyc76C_Dmel     ------------------------------------------------------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ---------------------------SYEI--SVLMMG-----N--------------S
CG10738_Dmel    ---------------------------VFTL--GYLTAS----QR--------------R
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     DNCLQHVILAFVLWIYLLILAITSLVSVVRL--NLQMLA----DR--------------H
Gyc76C_Dmel     ---------------------------VLTV--GYLTAL----TG--------------D
CG4224_Dmel     ---------------------------NCTIRALVLLPD----D---------------N
CG3216_Dmel     ---------------------------VYNV--GVLMAS----H---------------L
KSGC_Mmus       ---------------------------KLTV--GFHAPW-----N--------------I
HSER_Mmus       ---------------------------SYEI--SVLMMD-----N--------------S
CYGX_Mmus       ---------------------------TFTL--GVLGPW----DC---------------
CYGF_Mmus       ---------------------------PYKI--GVIGPW----TC---------------
CYGD_Mmus       ---------------------------VFKV--GVLGPW----AC---------------
ANPb_Mmus       ---------------------------NLTL--AVVLPE----HN--------------L
ANPa_Mmus       ---------------------------DLTV--AVVLPL----TN--------------T
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ---------------------------SKNV--R--RRF----EN---------------
gcy-8_Cele      ---------------------------RLTI--GHIGAI----GA---------------
gcy-7_Cele      ---------------------------VIRV--GFIHCR----DF--------------Q
gcy-6_Cele      ---------------------------VFHL--GFLHCDVLENNV--------------E
gcy-5_Cele      ---------------------------TLRV--GIAAAQ----DT--------------Q
gcy-4_Cele      ---------------------------VIRV--GITAAL----KT--------------E
gcy-3_Cele      ---------------------------KLKV--GIAAAQ----KT--------------Q
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ---------------------------SFQI--GHLEFE----NS--------------N
gcy-23_Cele     ---------------------------VVKV--GHIGAV----GS---------------
gcy-22_Cele     ---------------------------VLQV--GFLAAN----DN--------------T
gcy-21_Cele     ---------------------------PLKV--DYLAP----------------------
gcy-20_Cele     ---------------------------TIKV--GLMFSK----DT--------------A
gcy-2_Cele      ---------------------------TIKI--GIAAAQ----RT--------------Q
gcy-19_Cele     ---------------------------RIRV--GVAAVQ----TT--------------E
gcy-18_Cele     ---------------------------VIKI--GHIGAV----GV---------------
gcy-17_Cele     ---------------------------TIKV--GLLFVQ----NV--------------S
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ---------------------------TVKV--GLLFSK----DT--------------A
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ---------------------------EILI--SYLAAV----PTLMGEIDQYLLNLSAS
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ---------------------------TIKI--GIAAAQ----RI--------------Q
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ---------------------------VLKI--GSISSR----DN---------------
CYGF_Hsap       ---------------------------PYKI--GVVGPW----AC---------------
ANPb_Hsap       ---------------------------NLTL--AVVLPE----HN--------------L
ANPa_Hsap       ---------------------------NLTV--AVVLPL----AN--------------T
CYGD_Hsap       ---------------------------VFTV--GVLGPW----AC---------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ---------------------------SCT-DLHLL-MI----HG--------------T
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ---------------------------AIKT--IILH-R----AC--------------Q
Gcy1_Spur       ---------------------------KIHV--GLLAEW----TT--------------A
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ---------------------------QVRI--GVMFDF----PL--------------L
AqueK221_Aque   ---------------------------QVRI--GVILDF----PS--------------N
AqueK222_Aque   ----------------------------ASV--SNPDPI----DC--------------H


HSER_Hsap       ------------------------A----FAEPLKNLED--------------AVNEGLE
CG10738_Dmel    ------------------------PGNLDYNRPGLTISG--------------AI----S
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------IHSRDHELRAYVTLG--------------GL----P
Gyc76C_Dmel     ------------------------L----KTRQGLAISG--------------AL----T
CG4224_Dmel     ------------------------M----YQASLPRVLP--------------IL----K
CG3216_Dmel     ------------------------D----SPFDLERCGP--------------AV----D
KSGC_Mmus       ------------------------S----HPFSVQRLGA--------------GL----Q
HSER_Mmus       ------------------------A----YKEPMQNLRE--------------AVEEGLD
CYGX_Mmus       ------------------------D----PIFAQALPSI--------------AT----Q
CYGF_Mmus       ------------------------D----PFFSKALPEV--------------AA----A
CYGD_Mmus       ------------------------D----PIFARARPDL--------------AA----R
ANPb_Mmus       ------------------------S----YAWAWPRVGP--------------AV----A
ANPa_Mmus       ------------------------S----YPWSWARVGP--------------AV----E
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ---------------------------------EKYSST--------------KL----Y
gcy-8_Cele      ---------------------------------LRNDVK--------------IL----E
gcy-7_Cele      ------------------------S--APITVGYRTSAA--------------AA----S
gcy-6_Cele      ------------------------G--STTYINYRTSAS--------------AA----S
gcy-5_Cele      ------------------------S----GSIGWASCGG--------------TL----P
gcy-4_Cele      ------------------------N----GSIGWAYTGG--------------AV----P
gcy-3_Cele      ------------------------S----ASIGWNVCGG--------------AV----P
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------E----T--------R--------------IL----E
gcy-23_Cele     ---------------------------------MRNAEK--------------IL----Q
gcy-22_Cele     ------------------------T-ELAPFIGWGQVAG--------------AL----G
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------S--VIRSVGYRTSAA--------------AV----L
gcy-2_Cele      ------------------------T----SSIGWSVCGG--------------AV----P
gcy-19_Cele     ------------------------L----DSIGWPMSGG--------------AI----N
gcy-18_Cele     ---------------------------------MPNDAR--------------IL----N
gcy-17_Cele     ------------------------S--LQVGIGYRTSAA--------------AV----L
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------S--VMRAVGYRTSAA--------------AV----L
gcy-13_Cele     -------------------------------VGWQTSAS--------------AI----E
gcy-12_Cele     NSAQNSSKDRESFSKKLNQIVHCLT----TDAYVSVVSG--------------AL----V
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------T----SSIGWSVCGG--------------AV----P
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ---------------------------------AKMLES--------------IL----E
CYGF_Hsap       ------------------------D----SLFSKALPEV--------------AA----R
ANPb_Hsap       ------------------------S----YAWAWPRVGP--------------AV----A
ANPa_Hsap       ------------------------S----YPWSWARVGP--------------AV----E
CYGD_Hsap       ------------------------D----PIFSRARPDL--------------AA----R
T01A4.1_Cele    ----------------------------------QKNGG--------------LT----P
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------Y----GLMSYQYNDP--------------AI----D
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       -------------------------------LNEIHLRP--------------AI----D
Npr4_Spur       -----------------------------YSVDHRSILV--------------RS----S
Gcy1_Spur       ------------------------DG--DQGTLGFPALG--------------AL----P
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------P----NETQVYEEAGLEPGDVLPGKLLIPYS----P
AqueK221_Aque   ------------------------A----NETKLLQSAGLNPEDLLPGDMLLPYS----P
AqueK222_Aque   -----------------------------DISLAWNE-----------------------


HSER_Hsap       IVR------GRLQNAG--LN-V-TVN-A--------------------------------
CG10738_Dmel    LAV------EEVNAGR--LRDR-GHS-L--------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     LAI------EDVNKNP--NLLP-GKK-L--------------------------------
Gyc76C_Dmel     MAL------DEVNKDP--NLLP-NVY-L--------------------------------
CG4224_Dmel     VAE------QQIRSK---SLIPSHID-F--------------------------------
CG3216_Dmel     LAL------DEINKV----FLKP-HN-I--------------------------------
KSGC_Mmus       TVV------DKLNSEP--VGLG-NVS-W--------------------------------
HSER_Mmus       IVR------KRLREAD--LN-V-TVN-A--------------------------------
CYGX_Mmus       LAV------DQVNQDA--SLLP-GSQ-L--------------------------------
CYGF_Mmus       LAI------ERISRDK--TFDR-SYS-F--------------------------------
CYGD_Mmus       LAA------NRLNRDF--ALDG-GPR-F--------------------------------
ANPb_Mmus       LAV------EALGRA----L---PVD-L--------------------------------
ANPa_Mmus       LAL------GRVKARP--DLLP-GWT-V--------------------------------
odr-1_Cele      ----------RINQ----------------------------------------------
gcy-9_Cele      FNV------RSLNLK---K--TSLSN-F--------------------------------
gcy-8_Cele      VSH------KALQAE---GILDDDLD-V--------------------------------
gcy-7_Cele      IAV------DRLKRE---NLMS-GWE-F--------------------------------
gcy-6_Cele      IAI------DKIKRE---GLLL-GYD-F--------------------------------
gcy-5_Cele      IAV------QYLKSK---GFLT-DFD-V--------------------------------
gcy-4_Cele      LAL------QYLKSH---GYML-NFD-F--------------------------------
gcy-3_Cele      LAI------ERLKQA---GYVT-NFD-F--------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ICM------K---NA---G---SWRD-H--------------------------------
gcy-23_Cele     LSK------EQLTQE---GVLGNDFD-I--------------------------------
gcy-22_Cele     VAW------SRIVEY---GLLP-GYETM--------------------------------
gcy-21_Cele     ---------------F--GC----------------------------------------
gcy-20_Cele     VAK------DRIRAE---HLLD-QYD-F--------------------------------
gcy-2_Cele      MAI------ERLREF---GYVK-DFD-F--------------------------------
gcy-19_Cele     MAI------QKLRDD---GFIA-PFD-F--------------------------------
gcy-18_Cele     ISK------ENLIEE---GLVGDDIE-F--------------------------------
gcy-17_Cele     VTK------NKIRED---HVLD-GFD-FEKLRNVLKFSTKFQNIPDFFSSALKWPRKFYI
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     VAR------DRIRAE---HLLD-QYD-F--------------------------------
gcy-13_Cele     IAM------DRIKSE---HLID-NIG-I--------------------------------
gcy-12_Cele     AAI------VEINQDK--DLIP-AYQ-L--------------------------------
gcy-11_Cele     --------------N---------------------------------------------
gcy-1_Cele      LAI------ERLKEM---GFVK-DFD-F--------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    MAK------KKMTEQ---GVLGEKLD-I--------------------------------
CYGF_Hsap       LAI------ERINRDP--SFDL-SYS-F--------------------------------
ANPb_Hsap       LAV------EALGRA----L---PVD-L--------------------------------
ANPa_Hsap       LAL------AQVKARP--DLLP-GWT-V--------------------------------
CYGD_Hsap       LAA------ARLNRDP--GLAG-GPR-F--------------------------------
T01A4.1_Cele    NSL------QKAE-----------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       IAV------EEIRRRVTEGEYV-NIS-L--------------------------------
Gcy3_Spur       --S------D--------------------------------------------------
Npr3_Spur       IAF------EKVNNGAARGLYL-NFS-M--------------------------------
Npr4_Spur       LSW------HRLDNTA---F----------------------------------------
Gcy1_Spur       LAI------SLANQDS--NILN-GFD-V--------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   LAVSAYKQAVKINANP--AILP-YHH-L--------------------------------
AqueK221_Aque   LALITYETAKRLNLNS--TVLP-EHY-I--------------------------------
AqueK222_Aque   ----------EPPSEV--RVGQ-RFN-V--------------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     ------------------------------------------------------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ISEVLNFLEVLKMLENFFRIFQKISEVSRIFSNFPEISRRFLNCSQIFQQFPEVFRFFKE
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------------------------------------------------TFMYSD
CG10738_Dmel    ------------------------------------------------------QFVVAE
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------AFKPVD
Gyc76C_Dmel     ------------------------------------------------------DLRWND
CG4224_Dmel     ------------------------------------------------------EWLAH-
CG3216_Dmel     ------------------------------------------------------TLLKKK
KSGC_Mmus       ------------------------------------------------------EFTY--
HSER_Mmus       ------------------------------------------------------TFIYSD
CYGX_Mmus       ------------------------------------------------------DFKVL-
CYGF_Mmus       ------------------------------------------------------EYVIL-
CYGD_Mmus       ------------------------------------------------------EVALL-
ANPb_Mmus       ------------------------------------------------------RFVSSE
ANPa_Mmus       ------------------------------------------------------RMVLGS
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------SVF-T-
gcy-8_Cele      ------------------------------------------------------EII-S-
gcy-7_Cele      ------------------------------------------------------NFTIE-
gcy-6_Cele      ------------------------------------------------------KFTIL-
gcy-5_Cele      ------------------------------------------------------EYYME-
gcy-4_Cele      ------------------------------------------------------EFHVE-
gcy-3_Cele      ------------------------------------------------------EYYVE-
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------R-LIS-
gcy-23_Cele     ------------------------------------------------------EIL-N-
gcy-22_Cele     ------------------------------------------------------NLTWV-
gcy-21_Cele     --------------------------------------------------------ATG-
gcy-20_Cele     ------------------------------------------------------NFTIK-
gcy-2_Cele      ------------------------------------------------------EFIVD-
gcy-19_Cele     ------------------------------------------------------EVTVN-
gcy-18_Cele     ------------------------------------------------------EIV-S-
gcy-17_Cele     FSESSQKTFPEVSRIFSNISGVSKRLRNYFKFSEVSKKFSGGSKNVSNISKVSRRFLWD-
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------NFTVK-
gcy-13_Cele     ------------------------------------------------------NFIYV-
gcy-12_Cele     ------------------------------------------------------KYVFG-
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------EYIVD-
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------QII-T-
CYGF_Hsap       ------------------------------------------------------EYVIL-
ANPb_Hsap       ------------------------------------------------------RFVSSE
ANPa_Hsap       ------------------------------------------------------RTVLGS
CYGD_Hsap       ------------------------------------------------------EVALL-
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------T--LED
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------SYVFRE
Npr4_Spur       ------------------------------------------------------H-----
Gcy1_Spur       ------------------------------------------------------QFEWVD
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------CLYFTF
AqueK221_Aque   ------------------------------------------------------CLYYTF
AqueK222_Aque   ------------------------------------------------------SYHIEA


HSER_Hsap       GLIHNSGDCRSS------TCEGL----------------------DLLRKISNAQRMGCV
CG10738_Dmel    ------TYGE-E-------VVSI----------------------RQTAA-LWTQ-QVAA
CG9783_Dmel     ----------------------------------------------------------QE
Gyc32E_Dmel     ---IGHKMSAYR-------VKPL----------------------RAMTQ-MREA-GVTA
Gyc76C_Dmel     ------TKGD-T-------VLAT----------------------KAITE-MICD-GIAT
CG4224_Dmel     -----DTKCDA--------SLGV----------------------IKAMDGIIKQ-CAQV
CG3216_Dmel     ---GSYPSCSG--------ARAP----------------------GLAADMYFQD-DVIA
KSGC_Mmus       ----TNSTCSAK------E--SL----------------------AVFIDQVQKE-HISA
HSER_Mmus       GLIHKSGDCRSS------TCEGL----------------------DLLREITRDHKMGCA
CYGX_Mmus       -----PTGCDT--------PHAL----------------------ATF--VAHKN-IVAA
CYGF_Mmus       -----NEDCQT--------SKAL----------------------ASF--ISHQQ-MASG
CYGD_Mmus       -----PEPCLT--------PGSL----------------------GAV--SSALS-RVSG
ANPb_Mmus       ----LDGACSE--------YLAP----------------------LRAVDLKLYH-DPDL
ANPa_Mmus       -SENAAGVCSD--------TAAP----------------------LAAVDLKWEH-SPAV
odr-1_Cele      -----QHGCSGD-NSVKSASYAI----------------------NAVASRTSGE-LDFV
gcy-9_Cele      -----MESCNKY--------SGV----------------------EHAAFLHYLK-NASV
gcy-8_Cele      -----QTGCGES-------YEGV----------------------AVAADMYHLQ-KVKA
gcy-7_Cele      -----FDDCVE--------SEAA----------------------GMTVDLIEKH-NVDV
gcy-6_Cele      -----YDQCDE--------NIAA----------------------GNAIKLFAEH-NVDV
gcy-5_Cele      -----YTECDR--------ASVA----------------------KAGMKFMKEM-NVDV
gcy-4_Cele      -----YTECDL--------ANTV----------------------RAGLNFMKTN-NYDV
gcy-3_Cele      -----YTECDL--------ASTV----------------------RTGINFLKNL-EVDV
gcy-27_Cele     ----------------------------------------------------------Y-
gcy-25_Cele     -----LPSCHN--------FNGL----------------------ENAANLNYQY-SVDL
gcy-23_Cele     -----QMGCGES-------YEGV----------------------AVGADMYHVQ-GVRA
gcy-22_Cele     -----LTNCRE--------ADAV----------------------GSVINY-AEG-HAHV
gcy-21_Cele     ------TKCDDE-------A-AL----------------------NN---------GTIA
gcy-20_Cele     -----FDECSE--------SLAA----------------------GKVVELLTHD-NVDV
gcy-2_Cele      -----YTECDQ--------GSVV----------------------RAGIEFIKTH-KVDV
gcy-19_Cele     -----YTECDR--------SLGA----------------------AVGMEFMRTK-RLDV
gcy-18_Cele     -----RQACSES-------FEGV----------------------AVAAELYHVH-QVRA
gcy-17_Cele     -----FDECNE--------ILGA----------------------GKTVDLLEVK-KVDV
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     -----FDECTE--------GLAG----------------------GKTVELINHD-NVDV
gcy-13_Cele     -----FDDCNE--------AKAA----------------------GLSSKLLMDA-NVSA
gcy-12_Cele     ------NTCGND-------SHST----------------------RLFME-HWQA-GARV
gcy-11_Cele     ------------------------------------------------------D-GLLG
gcy-1_Cele      -----YTECDL--------GSVV----------------------RAGMEFIKTH-KVDV
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    -----VEGCGAS-------FEGV----------------------AAAAELYHVQ-KVDA
CYGF_Hsap       -----NEDCQT--------SRAL----------------------SSF--ISHHQ-MASG
ANPb_Hsap       ----LEGACSE--------YLAP----------------------LSAVDLKLYH-DPDL
ANPa_Hsap       -SENALGVCSD--------TAAP----------------------LAAVDLKWEH-NPAV
CYGD_Hsap       -----PEPCRT--------PGSL----------------------GAV--SSALA-RVSG
T01A4.1_Cele    -----NGDCSP-------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ----VTIRCFGG------ERQAG----------------------AIFAETYFKR-PLAA
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ----TGPDCGRP------VMEAP----------------------AIAAELYRRY-SLDG
Npr4_Spur       --------CW-------------------------------------------------P
Gcy1_Spur       ------THCD-I-------NIGM----------------------HAVSD-WWKR-GFVG
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ----T--PVDFLDI-----RLGSNYIFVHSRVRQVVNALYDMKQHLSHAELMVHY-SPLI
AqueK221_Aque   ----V-----------------------------------------------PQG-FRNI
AqueK222_Aque   ------TD----------------------------------------------------


HSER_Hsap       LIGPSCTY----------------------STFQM-YLDTE-------------------
CG10738_Dmel    YIGPQETC------------------------VHEGRMAAA-------------------
CG9783_Dmel     FGGPEVDK----------------------PDLLKGSIGSL-------------------
Gyc32E_Dmel     FIGPDESC------------------------TTEALLASA-------------------
Gyc76C_Dmel     IFGPEGPC------------------------YVEAIVSQS-------------------
CG4224_Dmel     IFGPVCDY------------SLVFGLPCEYVLAPISRYADV-------------------
CG3216_Dmel     FIGPACAF----------------------ALEPVARLAAY-------------------
KSGC_Mmus       LFGPACPE----------------------AAEVIGLLASE-------------------
HSER_Mmus       LMGPSCTY----------------------STFQM-YLDTE-------------------
CYGX_Mmus       FVGPVNPG----------------------FCSAAALLAQG-------------------
CYGF_Mmus       FVGPANPG----------------------FCEAASLLGTS-------------------
CYGD_Mmus       LVGPVNPA----------------------ACRPAELLAQE-------------------
ANPb_Mmus       LLGPGCVY----------------------PAASVARFASH-------------------
ANPa_Mmus       FLGPGCVY----------------------SAAPVGRFTAH-------------------
odr-1_Cele      FVGPTCTT----------------------DIRTIGDFAEI-------------------
gcy-9_Cele      YFGPGCNN----------------------EMLVIGRLAPR-------------------
gcy-8_Cele      FIGPYCNA----------------------EMDAVARMAAF-------------------
gcy-7_Cele      IIGPTMNQ----------------------PTLAAFIVSNY-------------------
gcy-6_Cele      LFGPTTNN----------------------AAMPVFILATY-------------------
gcy-5_Cele      VVGPSCGD----------------------ALAIMGTLSAI-------------------
gcy-4_Cele      IIGPPCAP----------------------ALKMMGTLSTI-------------------
gcy-3_Cele      IIGPPCSE----------------------AIRTMATLATL-------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     LIGAACDE----------------------ETQTVSRLALR-------------------
gcy-23_Cele     FIGPYCNA----------------------ELDAVAKMATF-------------------
gcy-22_Cele     VLGPPCVR----------------------PAQVAGSVAKY-------------------
gcy-21_Cele     ALGLMRDC------------------------YIQSTILNI-------------------
gcy-20_Cele     IIGPTCNR----------------------AGVAVASLADF-------------------
gcy-2_Cele      IIGPPCAQ----------------------ALRVMSFLAEN-------------------
gcy-19_Cele     VIGPPCRDRKSLSFRASSQFI-------ISAMEIMATMATY-------------------
gcy-18_Cele     FIGPYCAA----------------------ELEAVTKMATF-------------------
gcy-17_Cele     IFGPTCSR----------------------PALISSALATY-------------------
gcy-15_Cele     ---------------------------------------NI-------------------
gcy-14_Cele     IIGPTCNR----------------------AGIAVASLAAY-------------------
gcy-13_Cele     IVGPTCNA----------------------AGLAVVNLAGY-------------------
gcy-12_Cele     FIGPEKNC------------------------KTEAAMAAS-------------------
gcy-11_Cele     VVGVENDC------------------------KEIAALAQA-------------------
gcy-1_Cele      IIGPPCAQ----------------------ALRLMSFLAEN-------------------
daf-11_Cele     ----TCSS----------------------NFLRFANLTAE-------------------
C04H5.4_Cele    YFGPYCSK----------------------ELSPVATMASY-------------------
CYGF_Hsap       FIGPTNPG----------------------YCEAASLLGNS-------------------
ANPb_Hsap       LLGPGCVY----------------------PAASVARFASH-------------------
ANPa_Hsap       FLGPGCVY----------------------AAAPVGRFTAH-------------------
CYGD_Hsap       LVGPVNPA----------------------ACRPAELLAEE-------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       IMGPPCSN----------------------QMHSVAELAAA-------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ILGSPCSY----------------------ETVGIADLAAY-------------------
Npr4_Spur       LNGPDETN----------------------YEADCQGFHMGWSEQPPLEVKSGDTFEVHY
Gcy1_Spur       VIGPGCGC------------------------TYEGRLASA-------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   TIGHSLST----------------------NICPDASLSTL-------------------
AqueK221_Aque   ALGPTRTY----------------------SHQGVYLMINA-------------------
AqueK222_Aque   ----------------------------------------D-------------------


HSER_Hsap       ---LSYPMISAG---------------------------------------S--------
CG10738_Dmel    ---FNLPMISYY---------------------------------------C--------
CG9783_Dmel     ---KNLGFVIPG---------------------------------------A--------
Gyc32E_Dmel     ---WNTPMLSFK---------------------------------------C--------
Gyc76C_Dmel     ---RNIPMISYK---------------------------------------C--------
CG4224_Dmel     ---WQVPVLTTG---------------------------------------G--------
CG3216_Dmel     ---WNKPIITGM---------------------------------------GDQPPSSEG
KSGC_Mmus       ---WNIPLFDFV---------------------------------------G--------
HSER_Mmus       ---LNYPMISAG---------------------------------------S--------
CYGX_Mmus       ---WGKSLFSWA---------------------------------------C--------
CYGF_Mmus       ---WDKGIFSWA---------------------------------------C--------
CYGD_Mmus       ---AGVALVPWG---------------------------------------C--------
ANPb_Mmus       ---WRLPLLTAG---------------------------------------A--------
ANPa_Mmus       ---WRVPLLTAG---------------------------------------A--------
odr-1_Cele      ---WKSPVIGYE---------------------------------------P--------
gcy-9_Cele      ---WNVPIIAHM---------------------------------------S--------
gcy-8_Cele      ---WNIPIIGYM---------------------------------------A--------
gcy-7_Cele      ---FNRPIIAWG---------------------------------------L--------
gcy-6_Cele      ---YNIPLITWG---------------------------------------I--------
gcy-5_Cele      ---YKKLVLGWG---------------------------------------F--------
gcy-4_Cele      ---YKKPVLGWG---------------------------------------F--------
gcy-3_Cele      ---YKKPVLGWG---------------------------------------F--------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ---WHKLYLSS-------------------------------------------------
gcy-23_Cele     ---WNIPVVGYM---------------------------------------A--------
gcy-22_Cele     ---LDFPLILWG---------------------------------------P--------
gcy-21_Cele     ---NSKIAVSDV---------------------------------------C--------
gcy-20_Cele     ---YNVPVFQWG---------------------------------------L--------
gcy-2_Cele      ---YKKPVLGWG---------------------------------------F--------
gcy-19_Cele     ---YSTPMLGWG---------------------------------------L--------
gcy-18_Cele     ---WNIPIISYS---------------------------------------S--------
gcy-17_Cele     ---YNIPIFEWG---------------------------------------L--------
gcy-15_Cele     ---NLKIAVSDV---------------------------------------C--------
gcy-14_Cele     ---YNVPVFQWG---------------------------------------L--------
gcy-13_Cele     ---YNTPVLTWG---------------------------------------L--------
gcy-12_Cele     ---QNLPIISYR---------------------------------------C--------
gcy-11_Cele     ---YDASSLLVN---------------------------------------C--------
gcy-1_Cele      ---YKKPVLGWG---------------------------------------F--------
daf-11_Cele     ---MQSLEINI-------------------------------------------------
C04H5.4_Cele    ---WNIPIFAYT---------------------------------------A--------
CYGF_Hsap       ---WDKGIFSWA---------------------------------------C--------
ANPb_Hsap       ---WRLPLLTAG---------------------------------------A--------
ANPa_Hsap       ---WRVPLLTAG---------------------------------------A--------
CYGD_Hsap       ---AGIALVPWG---------------------------------------C--------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ---WDIPVLSGL---------------------------------------S--------
Gcy3_Spur       ------EVASRT---------------------------------------C--------
Npr3_Spur       ---WNLPVVTGV---------------------------------------S--------
Npr4_Spur       TVTANQHFFDWG---------------------------------------V--------
Gcy1_Spur       ---LNIPMIDYV---------------------------------------C--------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ---LKA----------------------------------------FLGVQL--------
AqueK221_Aque   ---VKQPVVHASLSHLIEYLRPLLSVKHHWTIDACPGNEHAWYVELLIGRES--------
AqueK222_Aque   ---FYESLFGFH---------------------------------------L--------


HSER_Hsap       -----------------FG-LS-----CDY-KETL-------------------------
CG10738_Dmel    -----------------TH-RDP-S--NKADFPTF-------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     -----------------SD-PIV-S--NKSTFHTF-------------------------
Gyc76C_Dmel     -----------------AE-YR------ASAIPTF-------------------------
CG4224_Dmel     -----------------NA-KEFNK--KSESYSTL-------------------------
CG3216_Dmel     ELTVTSGILGRIHKWKNENTGMF-K--DKSKYPTL-------------------------
KSGC_Mmus       -----------------QM-AAL-K--DHFWCDTC-------------------------
HSER_Mmus       -----------------YG-LS-----CDY-KETL-------------------------
CYGX_Mmus       -----------------EA-PEG-G-----------------------------------
CYGF_Mmus       -----------------VN-HEL-D--NKHSFPTF-------------------------
CYGD_Mmus       -----------------PG-TRA-A-----------------------------------
ANPb_Mmus       -----------------VA-SGFAA--KNEHYRTL-------------------------
ANPa_Mmus       -----------------PA-LGI-G--VKDEYALT-------------------------
odr-1_Cele      -----------------V-FEAR-G--VQ-ELTSV-------------------------
gcy-9_Cele      -----------------G-DDAL-S--DRVQFPTL-------------------------
gcy-8_Cele      -----------------A-SNNL-A--DKNAYPTL-------------------------
gcy-7_Cele      -----------------VNAAQL-D--DFERFPNA-------------------------
gcy-6_Cele      -----------------TSSATL-D--DESRFPTA-------------------------
gcy-5_Cele      -----------------VSDTQL-A--DTNRFPYV-------------------------
gcy-4_Cele      -----------------VSESEI-S--DMNRFPFV-------------------------
gcy-3_Cele      -----------------VSQADL-S--DMTRFPYL-------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     --------------------APL-S--TKEKESTT-------------------------
gcy-23_Cele     -----------------S-SNSF-A--DKTIFKTL-------------------------
gcy-22_Cele     -----------------PFDSSL-L--NQFEYPTI-------------------------
gcy-21_Cele     ------------------E-MDLSS--VKGFDQTS-------------------------
gcy-20_Cele     -----------------TTTADI-G--NFSRYQTT-------------------------
gcy-2_Cele      -----------------VSDTDL-S--DVIRFPYL-------------------------
gcy-19_Cele     -----------------VTDSKF-T--DTERYPYL-------------------------
gcy-18_Cele     -----------------V-PNAV-S--DRSVYKTL-------------------------
gcy-17_Cele     -----------------TSTRQL-T--DVKRFPTT-------------------------
gcy-15_Cele     ------------------E-MDLSS--VKGFDQTS-------------------------
gcy-14_Cele     -----------------TTAADI-G--NVSRYPTT-------------------------
gcy-13_Cele     -----------------TISSSF-I--DTSKYPTT-------------------------
gcy-12_Cele     -----------------ND-QDISR--DDYHYRTF-------------------------
gcy-11_Cele     -----------------ED--QVGE--SQMPSSTA-------------------------
gcy-1_Cele      -----------------VSDTDL-S--DVIRFPHL-------------------------
daf-11_Cele     ---------------------LK-G--YPYEHPTM-------------------------
C04H5.4_Cele    -----------------T-SAEF-A--NTKVYKTL-------------------------
CYGF_Hsap       -----------------VN-YEL-D--NKISYPTF-------------------------
ANPb_Hsap       -----------------VA-SGFSA--KNDHYRTL-------------------------
ANPa_Hsap       -----------------PA-LGF-G--VKDEYALT-------------------------
CYGD_Hsap       -----------------PW-TQA-E-----------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       -----------------SS-RDL-E--NEAIYSTL-------------------------
Gcy3_Spur       -----------------AE-SKL-S--DKSIYPTF-------------------------
Npr3_Spur       -----------------TS-AVL-D--DKSRYRTL-------------------------
Npr4_Spur       -----------------RNDTKY-AMENGRVFSKFKTGTEAMNWCHNTKCPAPNEANMEN
Gcy1_Spur       -----------------DE-NPV-S--DKSIYPTF-------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   -----------------KYDSSC-T--SEVR-DTQ-------------------------
AqueK221_Aque   -----------------KEPVLC-Y--D-NV-NVN-------------------------
AqueK222_Aque   -----------------SS-YNI-N--SSNDLRTF-------------------------


HSER_Hsap       -----------------------TRLM--------------------------S---PAR
CG10738_Dmel    -----------------------ARTR--------------------------P---PDT
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     -----------------------ARTL--------------------------A---PAS
Gyc76C_Dmel     -----------------------ARTE--------------------------P---PDT
CG4224_Dmel     -----------------------TRLK--------------------------G--AQVN
CG3216_Dmel     -----------------------TRMS--------------------------Y---CQC
KSGC_Mmus       -----------------------VTLV--------------------------P---PKQ
HSER_Mmus       -----------------------TRIL--------------------------P---PAR
CYGX_Mmus       -----------------------GDLV--------------------------P---TLP
CYGF_Mmus       -----------------------SRTL--------------------------P---SP-
CYGD_Mmus       -----------------------GTTA--------------------------P---AVT
ANPb_Mmus       -----------------------VRTG--------------------------P---SAP
ANPa_Mmus       -----------------------TRTG--------------------------P---SHV
odr-1_Cele      -----------------------INVA--------------------------Q--FSVG
gcy-9_Cele      -----------------------GSVA--------------------------L--TSAS
gcy-8_Cele      -----------------------ARISAFIISKIHKYYFFFNFLDDRSKVGISL--RTTN
gcy-7_Cele      -----------------------GILS--------------------------A---GQR
gcy-6_Cele      -----------------------GMLS--------------------------I---GSR
gcy-5_Cele      -----------------------ASVQ--------------------------P---TAQ
gcy-4_Cele      -----------------------ASVL--------------------------P---STK
gcy-3_Cele      -----------------------ITVL--------------------------P---TSQ
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     -----------------------IALK--------------------------P--HSLA
gcy-23_Cele     -----------------------ARVS--------------------------L--RTTN
gcy-22_Cele     -----------------------ASTT--------------------------S---STL
gcy-21_Cele     -----------------------VLMN-----------------------------SQTN
gcy-20_Cele     -----------------------VTLS--------------------------L---DTH
gcy-2_Cele      -----------------------TTVI--------------------------P---NSL
gcy-19_Cele     -----------------------TNIM--------------------------A---NSL
gcy-18_Cele     -----------------------ARVS--------------------------S--KNTN
gcy-17_Cele     -----------------------LPFS--------------------------V---NSY
gcy-15_Cele     -----------------------VLMN-----------------------------SQTN
gcy-14_Cele     -----------------------VTLS--------------------------L---DTH
gcy-13_Cele     -----------------------VTIV--------------------------P---VAK
gcy-12_Cele     -----------------------ARTV-----------------------------PPAG
gcy-11_Cele     -----------------------LQMS-----------------------------STQG
gcy-1_Cele      -----------------------TTVI--------------------------P---NSL
daf-11_Cele     -----------------------IDMV--------------------------T--RSPQ
C04H5.4_Cele    -----------------------LRTS--------------------------F--QSLN
CYGF_Hsap       -----------------------SRTL--------------------------P---SP-
ANPb_Hsap       -----------------------VRTG--------------------------P---SAP
ANPa_Hsap       -----------------------TRAG--------------------------P---SYA
CYGD_Hsap       -----------------------GTTA--------------------------P---AVT
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       -----------------------TRTT--------------------------Q--IIAS
Gcy3_Spur       -----------------------ARTI--------------------------P---TDD
Npr3_Spur       -----------------------TRTS--------------------------F---KTG
Npr4_Spur       CCLHHVNVHSCPQEHLADSGGICGPWV--------------------------PPSGDIF
Gcy1_Spur       -----------------------LRTI--------------------------P---PSI
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   -----------------------LSMA--------------------------A---PHL
AqueK221_Aque   -----------------------LGLS--------------------------T---TLY
AqueK222_Aque   -----------------------CHSS--------------------------P---CPT


HSER_Hsap       KLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTE-TE----DCFWYLNALEAS------VS
CG10738_Dmel    QISKSVV-------ALLLAFNWTQVSFLYLDDASGQYQP-----VAETILSTLTD-----
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     KVSKSVI-------SLLNAFHWNKFSIVVSSKPIW-GSD-----VARAIQELAEA-----
Gyc76C_Dmel     QVVKSLL-------ALLRYYAWNKFSILYEDV--W--SP-----VADLLKDQATK-----
CG4224_Dmel     NLGNVVR-------AILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEE-----
CG3216_Dmel     RLILVFA-------SVIRQFNWNHVALLVDRSELF--SW----TVGKNLEYGLRQ-----
KSGC_Mmus       EISAVLR-------ESLRYLGWEHIGVFGGSSA--D----SSWEQVDEMWGAVED--GLQ
HSER_Mmus       KLMYFLVDFWKVNNASFKPFSWNSSYVYKNGSE-PE----DCFWYLNALEAG------VS
CYGX_Mmus       SAADVLL-------SVMRHFGWARWAIVSSHQDIW--VT-----TAQQLATAFRT-----
CYGF_Mmus       --IRVLV-------TVMKYFQWAHAGVISSDEDIW--MH-----TANRVSSALRS-----
CYGD_Mmus       PAADALY-------VLLRAFRWARVALITAPQDLW--VE-----AGRALSTALRA-----
ANPb_Mmus       KLGEFVV-------TLHGHFNWTARAALLYLDARTDD--RPHYFTIEGVFEALQ------
ANPa_Mmus       KLGDFVT-------ALHRRLGWEHQALVLYADRLGDD--RPCFFIVEGLYMRVRE-----
odr-1_Cele      GVAETLV-------FLMKELEQVEITLVGSVKVLP-N--------GLSLSNDLRS--Y-N
gcy-9_Cele      EMAKATV-------TYLNLNNWDQIGIVRPSVGYE-R------LSVYSLQHQIKK--R-D
gcy-8_Cele      SIAEATC-------AMLRHYGWNKVAIITNTGILA-Y------DRVLSFEEVFHQ--R-G
gcy-7_Cele      SLGVAIR-------AVLKRYEWSQFVYAYFTEEDTEK----CVTMRNDLQQVVSY--F-G
gcy-6_Cele      SLAVTFR-------EVMKEYGWDQFVFAYSLEMNDEK----CETLRDDFQNMVAY--Y-G
gcy-5_Cele      TLGLATS-------RILEMFQFDRVALLYYKDDQ-DY----CKSVMDDVEATLSD--P-D
gcy-4_Cele      TLGVVTS-------KLLEIYGWDRVALLYFKNEL-DY----CSSVVNDVEKSLYN--E-S
gcy-3_Cele      TLGYAAS-------KLLELYKWDKVALLYYKSEV-NH----CGGVMNDVETTFND--P-S
gcy-27_Cele     -----------------SVYNWCYETVIGEN-----------------------------
gcy-25_Cele     GTAEVIL-------AMCKSMKWKEIGIIYSEETK--YTA----HAIYDM---LAE--Q--
gcy-23_Cele     SLAEAAA-------ALIKHYGWNKVAIATNTGAVA-F------ERVQSFEEVFHQ--R-G
gcy-22_Cele     YQATSLI-------RLLEYYKWTEIALIYYVARSD-------------------------
gcy-21_Cele     SLAKSVM-------YFLDKYQWKKVALVSPSTVLTAFAT----RVRSDLLD------ALT
gcy-20_Cele     SISLAVR-------EILRQYGWSEFVFIYSNDGDEEK----CAAMKDDMEKMGIE--N-S
gcy-2_Cele      MLGYAAS-------KMLTVYNWGRVAMLYYYSDI-KY----CSGVMNDVEATFNN--P-S
gcy-19_Cele     SLGFSLV-------KLLEMMEWDRVALVYEESAQ-DY----PLSVINDVETAINE--Y-D
gcy-18_Cele     SIAEATV-------ALLLHYKWLKVAIATNTGSTA-F------ERVSIFEEIMHR--E-G
gcy-17_Cele     SLAMAIL-------GTLKQFQWTEFVFLYCNDGDDEK----CESLKDDVQ----------
gcy-15_Cele     SLAKSVM-------YFLDKYQWKKVALVSPSAVLTAFAA----RVRSDLLD------ALT
gcy-14_Cele     SMALGVR-------EVLRRFEWDEFVFIYSNDGDEEK----CASMKDDLEKMGIE--N-S
gcy-13_Cele     SIAAAIH-------EVMIQFEWTEFVYVFVEDE---K----CGYFRDDLEQITSD--S-N
gcy-12_Cele     EIFKAFM-------SLMKQYNWRKFSVVYDVKKGQV-KN----ELFETLKRMVETENKFE
gcy-11_Cele     GKYRAFA-------KLAKSVGWNNLAVINFVEDGPA-DI----SYHDQLLD------ALS
gcy-1_Cele      MLGYAAS-------KMLTTFHWNRVALLYYFSDV-KY----CSGVMNDIEATFND--P-S
daf-11_Cele     NLAQNLV-------SLLRGFEWGQVGAVLCEECYE-GDELASEIYFSTIEDIFEN--N-N
C04H5.4_Cele    SISEATA-------AFMAHHNITKAAIVANIGTDS-F------EKIQSLEKALRS--R-G
CYGF_Hsap       --IRVLV-------TVMKYFQWAHAGVISSDEDIW--VH-----TANRVASALRS-----
ANPb_Hsap       KLGEFVV-------TLHGHFNWTARAALLYLDARTDD--RPHYFTIEGVFEALQ------
ANPa_Hsap       KLGDFVA-------ALHRRLGWERQALMLYAYRPGDE--EHCFFLVEGLFMRVRD-----
CYGD_Hsap       PAADALY-------ALLRAFGWARVALVTAPQDLW--VE-----AGRSLSTALRA-----
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       GYAYAIV-------EVLRHFGWGVASVIWDGGI-NY-WS-----LIEEAATR--E-----
Gcy3_Spur       LLTEAVS-------VLLEYFNWYNVSIVSSSESN--RLS-----VSESLQLKLPT-----
Npr3_Spur       VLAKAVV-------AFFEEYEWRQFALVWQYPGYSSLIA----IAMKELMET--Q-----
Npr4_Spur       THTESNV-------DSLNHTDWTTPLALVPDGVTS-------------------------
Gcy1_Spur       QVVEAMI-------LTLQRYDWDQVSVVVENIT--KYRN-----IFNTMKDKFDE-----
Gcy2_Spur       -------------------------TITY-------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   SLYSAGY-------SFVQRMGWKKFGLITTCDCFLRF-----FTTSDEVQ---LG--H-Y
AqueK221_Aque   NLYKATY-------MFVKKFNWKRIGILTTCTECVEA-----WPGNEYAV---IS--Y-Y
AqueK222_Aque   QMA------------SLRSFKE--------------------------------------


HSER_Hsap       Y-FSHELGFK---V-------------V------LRQ--DK-EFQDI--LMDHNR--KSN
CG10738_Dmel    --AGVSIRDI--RTWNT-----IY-H-H------GFM--DN-PFEAL--VEQTYA--NTR
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     --RNFTISHF--KYIS-DYI------PT------TKT--LS-QIDKI--IEETYA--TTR
Gyc76C_Dmel     --RNMTINHK--QSFIDNRVKCCEQMLD------CCR--SG-YWYQL--VQNTMN--RTR
CG4224_Dmel     -HSVYQLGFD---TS-------------------TWT--KA-DITRM--LKNVAM--QSR
CG3216_Dmel     -EGLLSFV-K---EL------------N------GNE--EE-VYENY--LKDASM--YAR
KSGC_Mmus       FHFNITASMR---Y-------------N------SSS--SD-LLQEG--LRNMSY--VAR
HSER_Mmus       Y-FSEVLNFK---D-------------V------LRR--SE-QFQEI--LTGHNR--KSN
CYGX_Mmus       --HGLPIGLV--TSL------------G------PGE---K-GATEV--CKQLHSVHGLK
CYGF_Mmus       --QGLPVGVV--LTS-------------------GRD--SQ-SIQKA--LQQIRQADRIR
CYGD_Mmus       --RGLPVALV--TSM------------E------TSD--RS-GAREA--LGRIRDGPRVR
ANPb_Mmus       -GSNLSVQHQ---VY------------A-------RE--PG-GPEQA--THFIRA--NGR
ANPa_Mmus       -RLNITVNHQ---EF------------V------EGD--PD-HYTKL--LRTVQR--KGR
odr-1_Cele      -EIMNSFKIR--EYVE-----------V------DEN--DV-DWTKV--DQKIKR--GAR
gcy-9_Cele      --I--NLNVI--LDIEP----------F------SSP--EEIISTGK--LTTLKS--MAR
gcy-8_Cele      --I--NVVKK--IMFDE----------F------ADS--KAMIASGL--LNDIKN--SAR
gcy-7_Cele      -D--IILAYS--IQV------------A------DIS--ND-GMIEA--LKKIQS--RGR
gcy-6_Cele      -D--IVLSYA--VQI------------M------DHS--EE-GLLAI--LKDVST--RGR
gcy-5_Cele      -LYPVRIVWK--GEL------------Q------SDN--EA-LTRST--LQAVKS--RAR
gcy-4_Cele      --KSVQIVMK--AEI------------D------GSN--SE-STSAT--LQVVKT--RAR
gcy-3_Cele      -TYSIQIVLK--AEI------------D------ASD--NV-TTNAV--ISSVKT--RAR
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     -EDDLKINVF--LET------------D------G----LS-NTYT------ILHSA--R
gcy-23_Cele     --I--NVVRK--IMLEE----------Y------TNA--KAIMNSGL--LQELEN--SAR
gcy-22_Cele     ------------------------------------------------------L--IPR
gcy-21_Cele     -ANKIDILVD--SR-------------L-------DP--MS-DITDK--VKEDAE--KAR
gcy-20_Cele     -D--VTMAYM--IQI------------Q------TVT--ME-SLQRT--LLEVSK--RGR
gcy-2_Cele      -TPNVNIVIK--AEI------------Y------LND--NE-TTDIV--FQSVKS--RAR
gcy-19_Cele     -TFAVNVVVK--QAL------------P------GGDLNDA-QYISV--LNRIKL--RCR
gcy-18_Cele     --V--TIVKK--VMFDE----------N------TDA--NEMMNSGQ--LGDLAA--NAR
gcy-17_Cele     -----------------------------------------------------------V
gcy-15_Cele     -ANKIDILVD--SR-------------L-------DP--MS-DITEK--VKEDAE--KAR
gcy-14_Cele     -D--VTLAYM--VQI------------Q------TVT--LD-ALQKA--LTEVSK--RGR
gcy-13_Cele     -Y--TSLSRT--IQI------------Y------DQS--YT-NLVRQ--LEKLKT--VSR
gcy-12_Cele     -EHKFEIMNVSKLEFSK----------MDISS--QQD--IQ-SIENA--IKSTMQ--TTR
gcy-11_Cele     -AESISLDFVKKGGFSS-----------TITSAMFTG--LE-SVIDV--ILETYM--KTR
gcy-1_Cele      -TPNVNIVIK--AEI------------Y------LND--NE-TTDNV--FQTVKS--RAR
daf-11_Cele     --I--ALKET--VRIGK------------------RE--NSVNISDA--ITIFEP--SAR
C04H5.4_Cele    --I--TVARR--VMFEE----------A------ASA--QDLVDNGY--MNELRD--NAR
CYGF_Hsap       --HGLPVGVV--LTT-------------------GQD--SQ-SMRKA--LQRIHQADRIR
ANPb_Hsap       -GSNLSVQHQ---VY------------A-------RE--PG-GPEQA--THFIRA--NGR
ANPa_Hsap       -RLNITVDHL---EF------------A------EDD--LS-HYTRL--LRTMPR--KGR
CYGD_Hsap       --RGLPVASV--TSM------------E------PLD--LS-GAREA--LRKVRDGPRVT
T01A4.1_Cele    -------I-N---EV---------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       -LDRIEFDYH---DF------------S------MRA--IS-DNFLA--LLNASK--VGR
Gcy3_Spur       --KNIHISDV--KIYASPYIPPLY-EPE------NGV--EP-EMRAI--VRETYE--HTR
Npr3_Spur       --ENVTM--Y---EF------------D------LRD--YG-SIKDA--LDAAAA--VSR
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       --RDYEILHE--EYYA-GFD-----PWD------YEM--DD-PFSEI--IQRTKE--TTR
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ----VP---------------------------------MR-FIEMFKMSGFEEH--EIN
AqueK221_Aque   ----DP---------------------------------SD-FISSF--TPFKGR--EIH
AqueK222_Aque   ---NCCVWHA--N-----------------------------------------------


HSER_Hsap       VIIMCGGP-----EFLYK---LKGDRA--VAEDIVIILVDL--FN-DQ-Y----------
CG10738_Dmel    IYLILGHY-----YEHVGLMVSLQRRGILSKGDYFVVGIDI--EQ-YD-PAK----PE-K
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     IYVFIGEH-----IAMVDFVRGLQNRRLLESGDYIVVSVDD--EI-YD-SNR---RVN-I
Gyc76C_Dmel     IYVFLGAA-----NSLVDFMSSMETAGLFARGEYMVIFVDM--MV-YS-ERE----AE-K
CG4224_Dmel     IVIMCADP-----QSIRQIMLTAEELNMIDSGEYVFINIEL--FS-RV-QYL--------
CG3216_Dmel     VVILSVRG-----VLVRKFMLAAHSLG-MTNGEWVFLDVEI--FQ-SE-Y-W----G---
KSGC_Mmus       VIILICSS-----EDARRILQAAVDLG-LDTGEFVFILLQQ--LE-VG-F----------
HSER_Mmus       VIVMCGTP-----ESFYD---VKGDLQ--VAEDTVVILVDL--FS-NH-Y----------
CYGX_Mmus       IVVLCMHSALLGGLEQTTLLHCAWEEG-LTDGRLVFLPYDT--LL-FA-LPY----G---
CYGF_Mmus       IIIMCMHSALIGGETQTHFLELAHDLK-MTDGTYVFVPYDV--LL-YS-LPY----K---
CYGD_Mmus       VVIMVMHSVLLGGEEQRYLLEAAEELA-LTDGSLVFLPFDT--LH-YA-LSP----G---
ANPb_Mmus       IVYICGPL-----EMLHEILLQAQREN-LTNGDYVFFYLDV--FG-ES-LRA----GP-T
ANPa_Mmus       VIYICSSP-----DAFRNLMLLALDAG-LTGEDYVFFHLDV--FG-QS-LQG----AQ-G
odr-1_Cele      MIVVCADF----YDIYSAF-YNIGIRS-LSGFRFIIVVI-L--NK-P--PD---------
gcy-9_Cele      IIVVELGMD---IHSVTNFMLAIHRSE-IKNEEFVFVIPWL--AH-Q--ND---------
gcy-8_Cele      IVVCLFSNT---RESSREFLTAANTQG-MNVNEYGYVFPWL--QD-GG-KD---------
gcy-7_Cele      IIVTCMKDG---IGLRRKWLLAAEEAG-MIGDEYVYVFSDI--KS-KG-YVV----PL-L
gcy-6_Cele      IIVPCFHEGN-SRGLHRRWMLVAARNG-FVNDEYVYIFPSL--RS-RG-YAV----PQ-A
gcy-5_Cele      IVLLCAISG----PEKRNYLISIAQQN-MTTNEYVHILLTM--RS-IG-YGV----QT-S
gcy-4_Cele      VILFCAHAG----GEKRFYLIQAGLLG-MNSSEYVHVMLSM--RS-VG-FGV----QT-S
gcy-3_Cele      IILWCAQLG----SEKRDYMIKISQLG-LDTDEYVHVLISM--RS-IG-FGV----QT-F
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ALISFLT-T---LDLS-KFFKTLKENA-FRPLEFSIVHVDC--NK-SE-ISN--------
gcy-23_Cele     VVVCAFSST---RDMNKEFMQAVTLSG-MNNANYAWILPWL--QL-ET-KD---------
gcy-22_Cele     FVIVCLESD----EARRNLMISISENG-MDGDEYVYIMAES--RR-AG-FAS--------
gcy-21_Cele     IFIICDWSS--NANLLRNYLFKLGEMNKMQSGEYFVLGYIS--YD-TN------------
gcy-20_Cele     IIIACFASG---RGFKKAFIASTVLAG-MSTEEYLYVFAEP--QS-RG-FYV----DE-A
gcy-2_Cele      IIFWCTQTA----IEKRDYLIKIATHD-MIGDEYVHIMLSM--RN-IA-FGA----QT-S
gcy-19_Cele     IIVSVFQTA----PTRRRYLKMIDQQG-MANEEYVHILLGL--RS-IG-FGK----QS-A
gcy-18_Cele     IIICLFSST---KELSKEFMQATYTMR-MNNAEYAYIIPWL--QS-GT-KD---------
gcy-17_Cele     IIVACVASG---NGSKRTLMQAVALEN-ANNSEYVYIMAET--NS-RG-FVV----EE-V
gcy-15_Cele     IFIICDWSS--NANLLRNYIFKLGEMNKMQSGEYFVLGYIS--YD-TN------------
gcy-14_Cele     IIIACFANG---RGFKKAFVASTVLAG-MSTDEYMYMFAEP--QS-RG-FYV----DE-I
gcy-13_Cele     IFTVCLPEA---GDIKRRFMLAAYDLD-MTTDEYVYLFAGP--KS-TA-YQQ----TS-S
gcy-12_Cele     IYLTF---D--NVRLFRTMLSIMGEMGL-TQQDYMLIYVDT--N--YDWLNVYHSMNN-H
gcy-11_Cele     IYVIVL--D--LPVSGTFFMNAMSTMGLLETGKYFVVMMSS--IE-SDAANYFG------
gcy-1_Cele      IILWCTQTS----VEKRDYLIKIATHD-MIGDEYVHIMLSM--RN-VA-FGT----QT-S
daf-11_Cele     VILLFLGNK---LNDYTEFMTAMSMNN-YTTEEYTPVIVIS--KN-SL-EL---------
C04H5.4_Cele    VILPIFSST---RDLSTVFRNATWLAN-MASPEFIYINPLI--VA-RN-SE---------
CYGF_Hsap       IIIMCMHSALIGGETQMHLLECAHDLK-MTDGTYVFVPYDA--LL-YS-LPY----K---
ANPb_Hsap       IVYICGPL-----EMLHEILLQAQREN-LTNGDYVFFYLDV--FG-ES-LRA----GP-T
ANPa_Hsap       VIYICSSP-----DAFRTLMLLALEAG-LCGEDYVFFHLDI--FG-QS-LQG----GQ-G
CYGD_Hsap       AVIMVMHSVLLGGEEQRYLLEAAEELG-LTDGSLVFLPFDT--IH-YA-LSP----G---
T01A4.1_Cele    ----------------------------------------Q--F--RL-P-L----N---
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       IIFMAVDG-----DTLREIMLHAYDLD-LINGDYAFINIIP--FR-DE-QLF----G---
Gcy3_Spur       IYIFIGEL-----WEVYELLHEMMYHGLLENGEYMVIWANQ--EN-FD-YKQ----LH-L
Npr3_Spur       IIILSAQG-----ELVREAMLHAFDTG-LVDGEYAFVSIEP--FS-NT-LVF----G---
Npr4_Spur       -IIAHIR-----------------------------------------------------
Gcy1_Spur       IYVFFGDA-----SDLRQFAMTALDEGILDSGDYVILGAVVDLEV-RD-SQD-YHSLDYI
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   IYIFLGPM-----VDFFRLLVEAYDNG-FSGSLRTFVWIVL--TFHPN-ITE--------
AqueK221_Aque   IYIFLGNT-----KSYLDMLLEFNLR--RKSDFRLFTWILP--FNCPS-F----------
AqueK222_Aque   IHVC--HP-----GN-----------------------------------CG----KP-S


HSER_Hsap       ----------------------------------F-ED------------N--VTAPDYM
CG10738_Dmel    YL-----------------------------RGLL-LE-----D-------VEPLAVQAF
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ME---------RNY-----------------LDPY-IR---KEK-------SKSLDKISF
Gyc76C_Dmel     YL-------------RR---V---------DQITF-MS---NCH-------STENFNQMA
CG4224_Dmel     ------------------------------TSQPW-YD---KND---TD-LNNERAQKAY
CG3216_Dmel     -------------------------------DKGW-EM---KDE-------HDAKARKAY
KSGC_Mmus       ----------------------------------W-KE---VLT----K-DKVIRFPKVY
HSER_Mmus       ----------------------------------F-EE------------N--TTAPEYM
CYGX_Mmus       -------------------------------NRSY-LV----------L-DDHGPLQEAY
CYGF_Mmus       -------------------------------HSPY-QV----------L-RNNPKLREAY
CYGD_Mmus       -------------------------------PEAL-AA----------F-VNSSQLRRAH
ANPb_Mmus       ----------------R---A---------TGRPW-QD---NRT----Q-EQAQALREAF
ANPa_Mmus       ----------------P---V---------PRKPW-ER---DDG-------QDRRARQAF
odr-1_Cele      -------------------------------E-----I---LNQ------P-NVKNLLYG
gcy-9_Cele      -------------------------------HYPW-EA---ANV------D-KQEVKLAF
gcy-8_Cele      -------------------------------ASPW-TG---ADG------SMLQKVKDQY
gcy-7_Cele      GG--------------G---E----------RPSW-IL---STGS---D-ENDTRALKAF
gcy-6_Cele      DG--------------T---F----------RYPW-TE---ATGP---Q-PGDQEALLGF
gcy-5_Cele      LG--------------K---K-TF--A-NGLTPLW-ES---FTVA--PD-GNETNARRAA
gcy-4_Cele      VG--------------K---K-PL--TLSGLPPIW-ES---FTVN--PD-GMEDLAKSVA
gcy-3_Cele      VG--------------K---T-TF--KLSGLTPVW-ES---FSNV--TD-GLENVAKRGA
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     -------------------------------FYTY-LD---NNAGEEPNPISAARLRKLY
gcy-23_Cele     -------------------------------MAPW-LG---ENG------EYQQNVKDHF
gcy-22_Cele     --------------------------------SFW-NG---T------D-GKNDLALRAA
gcy-21_Cele     --------------------------------YQW-LE---ASS-------GDQRLK---
gcy-20_Cele     DG--------------K---V----------HYSW-DD---TDGQ-LVTGLTNEQIRDAY
gcy-2_Cele      LG--------------K---P-TF--SQSGLTPIW-ES---FTEG--TD-DFEKMVKQAA
gcy-19_Cele     GL--------------T---KCELNCLSSGLAPFW-DI---A--P--DD-GLNDRLKQAA
gcy-18_Cele     -------------------------------LTPW-IG---ADG------EMLQRVKDHY
gcy-17_Cele     GG--------------K---W----------HYLW-EG---KFDD--SDTFSTEDSRTSM
gcy-15_Cele     --------------------------------YQW-LE---ASS-------GDQRLK---
gcy-14_Cele     NG--------------G---E----------HYSW-DD---TDGN-FVTGLTPEQIRDAY
gcy-13_Cele     TG--------------D---V----------VGIW-VD---WSEN--PD-GRDEEAKLAF
gcy-12_Cele     FLR-------------NTMTY---------LHHSW-DA---NNS-------SDRKMLDYA
gcy-11_Cele     F-----------------------------------NV---N------------------
gcy-1_Cele      LG--------------K---P-TF--SQSGLTPIW-ES---FTEG--TD-GFEKMAKQAA
daf-11_Cele     -------------------------------TFPW-KE---ND-----------AIAELF
C04H5.4_Cele    -------------------------------EPPVFYG---KM--------AQKSIKAEN
CYGF_Hsap       -------------------------------HTPY-RV----------L-RNNPKLREAY
ANPb_Hsap       ----------------R---A---------TGRPW-QD---NRT----R-EQAQALREAF
ANPa_Hsap       ----------------P---A---------PRRPW-ER---GDG-------QDVSARQAF
CYGD_Hsap       -------------------------------PEAL-AA----------L-ANSSQLRRAH
T01A4.1_Cele    -------------------------------DRR--------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       -------------------------------DDSW-ER---GDN-------RDEEAKVAY
Gcy3_Spur       FQ-----------------------------GDPY-LR-----Q-------PSREVMMYY
Npr3_Spur       -------------------------------DDNW-KQ---NDG-------RDDDAKKAY
Npr4_Spur       ----------------------------------------------------IGNWQAAL
Gcy1_Spur       LDTSEYLNQINPDYARL---F---------KNREY-TR-----S-------DNDRALEAL
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   -------------------------------SEVF-KQ---HSF----S--PEDK-AKVY
AqueK221_Aque   -------------------------------SKVF-DKISRKYF----N--SHQI-QRIE
AqueK222_Aque   QI-----------------------------CGPW-VD---NDQ-------VQSTH----


HSER_Hsap       KNVLV-LTL--SP-G-N-SLLNSSF-SR--------------------NL----------
CG10738_Dmel    QSYLG-IV----P-T-A-SVSFATF-ANEVNKYMERPP---FN----FPN----P----L
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     RSVIK-ISM--TY-P---------------------------------------------
Gyc76C_Dmel     RSLLV-VAS--TP---P-TKDYIQF-TKQVQKYSSKPP---FN----LEI----P----R
CG4224_Dmel     TAMLT-VTP--KQ-P-N-DNEYTRV-SNEIKAI-AAEK---YN----YTF----S-----
CG3216_Dmel     EALLR-VSL--LQ-P-T-SPKFQDF-ADNVREN-ALYD---YN----YTF----G-----
KSGC_Mmus       ESVFL-IAP--SA-Y-GGGIGDDGF-RKQVSQELRRPP---FQ----SSI----T-----
HSER_Mmus       DNVLV-LTL--PS-E-Q-STSNTSV-AE--------------------RF----------
CYGX_Mmus       DAVLT-VSL--ES-S-PESH---AF-TATE-MS-GGAT---AN-----------------
CYGF_Mmus       DAVLT-ITV--ES-H-EK-TFYEAY-AEAA-AR-GEIP---EK-----------------
CYGD_Mmus       DAVLT-LTR--RC-P-PGGSVQDSL-RRAQ-EH-QELP---LD-----------------
ANPb_Mmus       QTVLV-ITY--RE-P-P-NPEYQEF-QNRLLIR-ARED---FG----VEL----A-----
ANPa_Mmus       QAAKI-ITY--KE-P-D-NPEYLEF-LKQLKLL-ADKK---FN----FTM----E-----
odr-1_Cele      SNAFIISP------L-Q-EQYSDAF-SI-MQDV----I---------P------------
gcy-9_Cele      ENTIIITA---HG-Y-D-KKFFDDF-QMKFSAV----T---------G------------
gcy-8_Cele      ANAIIIDDV--NS-F-D-NTIVGPF-IERIKDV----G---------L------------
gcy-7_Cele      KQSIFICDM--MGQG-SIATNYTIF-GQEIIARMKEAP---YF----CT-----K----D
gcy-6_Cele      QKSIFIVDM--QGQG-NVGSNYTQF-EHEIIQRMKEPP---YN----CT-----D----A
gcy-5_Cele      EKML-VIDV--NSDV--QDAEFLQYLTKNIADAVRNPP---MK----CNT----S----E
gcy-4_Cele      AKMI-VIDT--SSEV--RDKTFLQYMTKNIVYAIREPP---LS----CKV----P----E
gcy-3_Cele      TNVL-VIDL--NSEV--SDKAYLDYMQRNILNVVKLPP---LN----CST----V----D
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     RHVAL-LKN--SHD--D-MEKTEEF-AKKYGLV-ARCS---LC----FVA----CFHFFS
gcy-23_Cele     ANSFIIDDV--NG-F-D-NTLVTPF-KERLEAS----G---------Y------------
gcy-22_Cele     RKFL-VMDN--QKYN-----DTTTF-VQEVRAAFSRPP---FS----CP----------N
gcy-21_Cele     ------I--TP---------RWD-------------------------------------
gcy-20_Cele     GKVLYICDN--MGEPTTITTQYTNF-TSQVISRMAEQP---FN----CV-----Q----D
gcy-2_Cele      TRMF-VLDV--NSEV--ADKKYLDYLQKNIMKAVQSPP---MN----CST----V----E
gcy-19_Cele     TRML-VMDL--STDV--PDINYLNTFTMNCGAVVVNPP---VS----CAT----P----A
gcy-18_Cele     ANAIIVDDV--NG-F-D-DSVVSSF-VEKIEKH----G---------M------------
gcy-17_Cele     ANLLFLVDN--MGMNNVVTPQYLNF-SKNVIEMMKDEP---FN----CV-----E----D
gcy-15_Cele     ------I--TP---------RWD-------------------------------------
gcy-14_Cele     GKVLYICDN--MGLPTTITPEFANF-SSQLISRMTEQP---FN----CV-----Q----D
gcy-13_Cele     MRTMVIVAT--P----VQGEQYAAF-KKEVIERMKLPP---YN----CV-----D----E
gcy-12_Cele     RSALS-IIPTPVK-L-N-SQRFYNF-WKKAGDYM--HH---FG----VQK----A-----
gcy-11_Cele     -----------RD---F-SDEWTSF-QKRVDGDA-SKT---FCPPMCNTK----A-----
gcy-1_Cele      TRMF-VLDV--NSEV--ADKKYLEYMQKNIIKAVQSPP---MN----CST----V----E
daf-11_Cele     DKAIIVYN---NC-Y-D-KSKISSF-LSSYSF---------------S------------
C04H5.4_Cele    PNTIQIYNS--YG-F-S-DDLLNEF-LAIFDQN---------------------------
CYGF_Hsap       DAVLT-ITV--ES-Q-EK-TFYQAF-TEAA-AR-GEIP---EK-----------------
ANPb_Hsap       QTVLV-ITY--RE-P-P-NPEYQEF-QNRLLIR-ARED---FG----VEL----G-----
ANPa_Hsap       QAAKI-ITY--KD-P-D-NPEYLEF-LKQLKHL-AYEQ---FN----FTM----E-----
CYGD_Hsap       DAVLT-LTR--HC-P-SEGSVLDSL-RRAQ-ER-RELP---SD-----------------
T01A4.1_Cele    --------V--SS-P-S-SEAT----RKK-------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       QALMT-IRV--FE-P-T-SEAYREF-EENVRER-QKRD---FN----ITD----S-----
Gcy3_Spur       RTLLA-LFL--SP-A-T-DPSYDNF-QRKTYKKLQEPP---FN----FDF----G----D
Npr3_Spur       ESLLI-FRL--FK-P-Q-TDEYRAF-QRELERR-EILD---YN----WTR----P-----
Npr4_Spur       HHIVT-VRP--RSEC--GNKNCEEL-EGE-------TC---SN----CPA---------D
Gcy1_Spur       KSVII-VTG--AP-V-LKTRNWDRF-STFVIDNALDAP---FN----GEL----E----L
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   H---------------------------MLVGAIAIQP---FD----N------------
AqueK221_Aque   F---------------------------ELRGSFVIHPVQRFK----QDKNGRVI-----
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       -------SPT-KR--D---FA------LAYLNGIL-LF-G-HM-LKIFL---EN-GEN--
CG10738_Dmel    G-PFGG-VKQ-IS--A---EA------AYLYDAVH-LY-A-KA-LMEVL---DS-GGRP-
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ---QNP-HIR-VP--I---YG------LHLYDSVM-IY-V-RA-ITEVL---RL-GGDI-
Gyc76C_Dmel     LFVESN-FSKFIS--I---YA------AYLYDSVK-LY-A-WA-VDKML---RE-ETRV-
CG4224_Dmel     -----D-NEP-IS--A---FV------TSFFDGVL-LY-A-NA-LNESI---RE-DPTM-
CG3216_Dmel     -----E-GEE-VN--F---FI------GAFYDGVY-LL-G-MA-LNETL---TE-GGDI-
KSGC_Mmus       -----S-EDQ-VS--P---YS------AYLHDALL-LY-A-QT-VEEMR---KA-EKDF-
HSER_Mmus       -------SSG-RS--D---FS------LAYLEGTL-LF-G-HM-LQTFL---EN-GEN--
CYGX_Mmus       ----LE-PEQ-VS--P---LF------GTIYDAVI-LL-A-HA-LNRSE---TH-GAGL-
CYGF_Mmus       ----PD-SNQ-VS--P---LF------GTIYNSIY-FI-A-QA-MNNAM---KK-NGRA-
CYGD_Mmus       ----LN-LKQ-VS--P---LF------GTIYDAVF-LL-A-GG-VKRAR---TAVGGGW-
ANPb_Mmus       -----P--SL-MN--L---IA------GCFYDGIL-LY-A-QV-LNETI---QE-GGTR-
ANPa_Mmus       -----D--GL-KN--I---IP------ASFHDGLL-LY-V-QA-VTETL---AQ-GGTV-
odr-1_Cele      --NLAD--DQ-FT------TF------LRIYHACY-AY-C-VGSVNGAE---TQ-TDNY-
gcy-9_Cele      --VLAN--HY-AT--L---SY------MSLYDALF-LY-G-LA-LRDAF---ED-GGGY-
gcy-8_Cele      --TEAD-VDI-AN--IY--GY------LYLFDALK-LY-A-IA-ARKVL---NE-TGKA-
gcy-7_Cele      C-EGEN-FTV-AA--T---YA------GQLHDAVY-AY-G-VA-LDKML---KA-GQI--
gcy-6_Cele      C-ASPE-YQT-AA--T---YA------GQLHDSVY-IY-G-VV-MDQIM---KT-VPN--
gcy-5_Cele      C-INAS-STS-MG--S---YA------RHLFDVFY-LY-G-MA-VSKLN---ST-DPT--
gcy-4_Cele      C-LITN-ATG-MG--A---YA------RHLFDVFY-MY-G-MA-VSSLN---ST-DPN--
gcy-3_Cele      C-VSST-ATG-MG--A---YA------RHLFDVVY-LY-G-IA-LTRVN---ST-DSA--
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     Y-SFVSVFAY-LT--P---YLTTFQPSYTLYKALI-LCDGLQL-LNNYT---AP-RGNL-
gcy-23_Cele     --STDD-LEM-KN--IY--GY------IHLYDALR-LY-A-LA-VRATM---NE-TGNE-
gcy-22_Cele     C-TN---IDP-TV--S---QV------GPLGDALL-LY-A-YA-LNRSI---AT-GNP--
gcy-21_Cele     -------------------RI------KLLFDSIQ-YL-A-DA-TNDAL---NI-GAN--
gcy-20_Cele     C-SNQS-YKH-AA--T---YA------GQLADSFY-AY-A-FA-LNKSL---TQ-DPTR-
gcy-2_Cele      C-MTAN-TTI-MG--G---YA------RQLFDVVY-LY-G-VA-LTNTN---ST-DPA--
gcy-19_Cele     C-INAS-TSP-PS--A---FA------RSLHDVFY-LY-G-LA-ITNLY---NQ-DPA--
gcy-18_Cele     --QKSD-ID--TN--IN--GY------LHLFDSLK-LY-A-LA-IRKVL---NE-TDNE-
gcy-17_Cele     C-VGEE-YSS-VA--K---YA------GQLADAFY-AY-A-VA-VNRLL---TA-NPQ--
gcy-15_Cele     -------------------RI------KLLFDSIQ-YL-A-DA-TNDAL---NI-GAN--
gcy-14_Cele     C-SNST-YKV-PA--T---YA------GQLFDAFY-AY-G-VA-LNRSL---TQ-DPTR-
gcy-13_Cele     C-KEKE-YQE-AA--E---YA------DQLHDTIY-LY-A-LI-LNKTI---EE-QGI--
gcy-12_Cele     -----D-NLK-GN--R---IA------CYLYDAVY-LY-A-KA-IHELV---EE-YGND-
gcy-11_Cele     K-GIANNDPW-SDDAYWYSES------PSIVDAY--DL-G-RL-LSETV---KV-HGAS-
gcy-1_Cele      C-MTAN-TTI-MG--G---YA------RHLFDVVY-LY-G-IA-LTHTN---ST-DPA--
daf-11_Cele     --TIEE--TI-----I----S------LQMYEGYH-LL-G-YY-LYTAI---TN-TTL--
C04H5.4_Cele    --QRIY-IDE-KD--LF--NY------VALYESFC-VF-A-KL-TEKYLHSLKE-KPEDG
CYGF_Hsap       ----LE-FDQ-VS--P---LF------GTIYNSIY-FI-A-QA-MNNAM---KE-NGQA-
ANPb_Hsap       -----P--SL-MN--L---IA------GCFYDGIL-LY-A-EV-LNETI---QE-GGTR-
ANPa_Hsap       -----D--GL-VN--T---IP------ASFHDGLL-LY-I-QA-VTETL---AH-GGTV-
CYGD_Hsap       ----LN-LQQ-VS--P---LF------GTIYDAVF-LL-A-RG-VAEAR---AAAGGRW-
T01A4.1_Cele    ----------------------------------------------NSN---EE-D--P-
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       -----G-AGS-NI--F---LA------SAFYDVMI-LY-S-LA-INETI---AE-GGDV-
Gcy3_Spur       A---VD-VLG-IP--I---EA------AYLYDNVYNVY-A-PA-LNETL---AA-GYDI-
Npr3_Spur       -----D-PDH-NN--Y---FA------SAFHDAVI-LY-S-LA-VNETL---AE-GGNI-
Npr4_Spur       C-GRCP-LS--IG--A---LS------GIIAG-LY-------------------------
Gcy1_Spur       R-------AE-ID--F---AS------VYMFDATM-QL-L-EA-LDRTH---AA-GGDI-
Gcy2_Spur       -------------------------------DDL-SV-----------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   -------CST-GL--I---RS------GVITDAIT-VH-S-LA-AMSCL---EE-KAAN-
AqueK221_Aque   --SMYE-GGK-GL--N---SA------GFIIDALQ-LD-I-FT-ADEFL---KT-KAAR-
AqueK222_Aque   ----------TIA--T---F-------GNINDTFT-A-----------------------


HSER_Hsap       -------------------ITTPKFAHA-FR--NLTFEGY--------------DGP-VT
CG10738_Dmel    R-------------------NGSAIVAA-IK--GSRYRSA--------------MGYHVY
CG9783_Dmel     -----------------------------------AAPGS--------------AGA-IT
Gyc32E_Dmel     Y-------------------DGNLVMSH-IF--NRSYHSI--------------QGFDVY
Gyc76C_Dmel     LT---------DDVIFEVASNGTRVIDTIIK--NRTYMSI--------------TGSKIK
CG4224_Dmel     LT---------R------PINGTDMVRR-MW--NRSFTGI--------------TGN-VT
CG3216_Dmel     -------------------RDGVNITRR-MW--NRTFEGI--------------TGH-VR
KSGC_Mmus       -------------------RDGRQLIST-LRAGQVTLQGI--------------TGP-VL
HSER_Mmus       -------------------VTGPKFARA-FR--NLTFQGF--------------AGP-VT
CYGX_Mmus       --------------------SGAHLGDH-VR--ALDVAGF--------------SQR-IR
CYGF_Mmus       --------------------SAASLVQH-SR--NMQFYGF--------------NQL-IK
CYGD_Mmus       -------------------VSGASVARQ-VR--EAQVSGF--------------CGV-L-
ANPb_Mmus       -------------------EDGLRIVEK-MQ--GRRYHGV--------------TGL-VV
ANPa_Mmus       -------------------TDGENITQR-MW--NRSFQGV--------------TGY-LK
odr-1_Cele      H----------T------A----------MS--GKAVTTK--------------YG-TFT
gcy-9_Cele      N----------V------HMNGSLIWSR-MT--NRQFIGM--------------TG-QVL
gcy-8_Cele      E----------N------LLNGRMMWQN-MR--KLKFVGMVGASG-------IASG-QVS
gcy-7_Cele      A----------Q------YRNATAFM-R-YF--PQSFIGM--------------SG-NVT
gcy-6_Cele      -----------Q------YKNGTAFP-R-KM--AGVFNGV--------------GG-TVA
gcy-5_Cele      ------------------VYGNLNLLMP-QM--VTSFDGM--------------TG-RVQ
gcy-4_Cele      ------------------VYGNLSLLIP-KF--TTAFEGM--------------TG-EVK
gcy-3_Cele      ------------------VYDDMSKLIP-QF--VTSFNGM--------------TG-LVA
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     S----------I------VQQLPYLWNH-VT--NTETQGY--------------SG-PVF
gcy-23_Cele     N----------S------YLNGKEVWNH-MR--RITFPGLVSNAG-------VTSG-TVM
gcy-22_Cele     ------------------NPTGTEFCEV-AK--GMEFLGF--------------TG-KVI
gcy-21_Cele     ------------------IYQSDIFYEY-LI--SRKIDSV--------------TGVTEF
gcy-20_Cele     S----------N------LKNGSFVL-S-NI--GMTFQGV--------------GGEAVT
gcy-2_Cele      ------------------VYDDVDVIVP-QF--VTSFQGM--------------TG-KVV
gcy-19_Cele     ------------------YLNDIDKING-AL--QLNFAGL--------------TG-EVS
gcy-18_Cele     A----------Y------VTNGQFIWNR-MR--RMKFEGVVSRSSSEENKDAGAIG-TVL
gcy-17_Cele     A----------E------IRNGTMIL-R-NI--GMTFEGV--------------GGGDLT
gcy-15_Cele     ------------------IYQSDIFYEH-LI--SRKVDSV--------------TGVTEY
gcy-14_Cele     A----------N------LKNGSFVL-S-DI--GMSFQGV--------------GGGTVT
gcy-13_Cele     E----------Q------IANGSNIVTR-GA--GIEFEGM--------------SG-VVR
gcy-12_Cele     DSYD-------P------TADGKAIIDR-IV--NKKYRSI--------------QGFDMR
gcy-11_Cele     -----------L------LRDPESLVQT-MS--GRGVTSL--------------LGYVTK
gcy-1_Cele      ------------------VYGDVDVLVH-QF--VTSFQGM--------------TG-HVV
daf-11_Cele     -------------------FNYVQPEKA-IS--SMSIPGP--------------FG-EIF
C04H5.4_Cele    K----------I------RIDGKALWN--MA--IRT------------------------
CYGF_Hsap       --------------------GAASLVQH-SR--NMQFHGF--------------NQL-MR
ANPb_Hsap       -------------------EDGLRIVEK-MQ--GRRYHGV--------------TGL-VV
ANPa_Hsap       -------------------TDGENITQR-MW--NRSFQGV--------------TGY-LK
CYGD_Hsap       -------------------VSGAAVARH-IR--DAQVPGF--------------CGD-L-
T01A4.1_Cele    -------------------ENGAKKSLS-LK--NR-------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       -------------------YDGHAVTKK-MW--NRTFDGL--------------YGK-VK
Gcy3_Spur       R-------------------NGTEILRR-IL--CRKHASI--------------TGRPKY
Npr3_Spur       -------------------SDGYVITRK-MW--GRSFQGI--------------SGT-VT
Npr4_Spur       -------------------CSRRQFLLR-YR--DTGQRGF--------------GGS-V-
Gcy1_Spur       Y-------------------DGEEVVST-LL--NSTYRSK--------------TDTFYQ
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   S-GVNITDVILE------RDDYDVITRH-LF--NTTLNGI--------------TG-ILT
AqueK221_Aque   L-GANLSEVSIA------SADKLNVIAT-ML--NTTFVGE--------------TG-RVM
AqueK222_Aque   ------------EVFIEVP----------------EINHM--------------------


HSER_Hsap       LDDWGDVDST-MVLL--------------------------------------YT-----
CG10738_Dmel    IDENGDAAGN-YTVL--------------------------------------AR-----
CG9783_Dmel     TTANG-------------------------------------------------------
Gyc32E_Dmel     IDSNGDAEGN-YTVI--------------------------------------TL-----
Gyc76C_Dmel     IDQYGDSEGN-FSVL--------------------------------------AY-----
CG4224_Dmel     IDANGDRLSA-YSLL--------------------------------------DM-----
CG3216_Dmel     IDDNGDRDAD-YSIL--------------------------------------DL-----
KSGC_Mmus       LDSQGKRHVD-YSVY--------------------------------------AL-----
HSER_Mmus       LDDSGDIDNI-MSLL--------------------------------------YV-----
CYGX_Mmus       TDGKGRRLAQ-YVIL--------------------------------------DT-----
CYGF_Mmus       TDSNGNGISE-YVIL--------------------------------------DT-----
CYGD_Mmus       ---GRTEEPS-FVLL--------------------------------------DT-----
ANPb_Mmus       MDKNNDRETD-FVLW--------------------------------------AM-----
ANPa_Mmus       IDRNGDRDTD-FSLW--------------------------------------DM-----
odr-1_Cele      FDNSGSVLTN-YAVF--------------------------------------TI-----
gcy-9_Cele      MNNKAIRVPS-YATY--------------------------------------HA-----
gcy-8_Cele      MDDRAERAPL-YRGF--------------------------------------FV-----
gcy-7_Cele      INEKGTRNPT-LFLL--------------------------------------AL-----
gcy-6_Cele      IDEGGGLQPT-LFVL--------------------------------------TL-----
gcy-5_Cele      IGQNLYRVPT-YQLY--------------------------------------GL-----
gcy-4_Cele      LNEDLARKPL-YQVY--------------------------------------GL-----
gcy-3_Cele      INQNLSRMPL-YQLY--------------------------------------GL-----
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     IGNDGVRLPY-YEMH--------------------------------------MW-----
gcy-23_Cele     MDDIAERAPV-YAAF--------------------------------------YV-----
gcy-22_Cele     INQNSTRTPL-FVVY--------------------------------------NL-----
gcy-21_Cele     IDGYGAIVGS-IQIY--------------------------------------YH-----
gcy-20_Cele     LDESGSRIVQ-VYMF--------------------------------------AM-----
gcy-2_Cele      ISPNLTRMPI-FQLY--------------------------------------GL-----
gcy-19_Cele     INANNSRVPK-LMLY--------------------------------------AL-----
gcy-18_Cele     MDDVADRAPI-FSAF--------------------------------------YI-----
gcy-17_Cele     VDPDSARTSE-IIMI--------------------------------------GL-----
gcy-15_Cele     IDGYGAIVGS-MQIY--------------------------------------YH-----
gcy-14_Cele     LDDTGTRIVQ-VYMF--------------------------------------AL-----
gcy-13_Cele     MNGIGYRLPN-MNLA--------------------------------------NL-----
gcy-12_Cele     IDERGNSKGN-FSLL--------------------------------------SW-----
gcy-11_Cele     FNTNGVSQRE-YILW--------------------------------------AP-----
gcy-1_Cele      ISPNLTRMPI-FQLY--------------------------------------GL-----
daf-11_Cele     INSNGQRIAG-IREL--------------------------------------IIWCRGY
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       TDSNGNGISE-YVIL--------------------------------------DT-----
ANPb_Hsap       MDKNNDRETD-FVLW--------------------------------------AM-----
ANPa_Hsap       IDSSGDRETD-FSLW--------------------------------------DM-----
CYGD_Hsap       ---GGDEEPP-FVLL--------------------------------------DT-----
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       INENGDRDSE-YSLW--------------------------------------DM-----
Gcy3_Spur       IDARGDAYAD-ITVI--------------------------------------AV-----
Npr3_Spur       INENGDRSGD-YSLW--------------------------------------DM-----
Npr4_Spur       ISIRGDCDTS-ASSVSGFVHTAHHKQLADSGGICGPWVPPSGDIFTHTESNVDSL-----
Gcy1_Spur       FDENGDGVKP-YVLL--------------------------------------HL-----
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   FDRYCNRVANTFVIT--------------------------------------NF-----
AqueK221_Aque   FNNACNRLTNIFKVI--------------------------------------NM-----
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       -----SV----DTKKYKVL------------LTY-------D------------------
CG10738_Dmel    -----GSV---RNGRNQTVL-----GLRP-VGTFI-----HR----N----SSL------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     -----QND---V-GSGASIGSLAKMSMQP-VGFFA-----YD----K-------------
Gyc76C_Dmel     -----KPH---K-WNNSNNMP-CNYHMVP-VAYFH-----------Q-------------
CG4224_Dmel     -----NP----TTGRFEIV------------AHF-------L------------------
CG3216_Dmel     -----DP----INGKFSVV------------AHY-------S------------------
KSGC_Mmus       -----QE----SGNRSLFL---------P-FLHY-------D------------------
HSER_Mmus       -----SL----DTRKYKVL------------MKY-------D------------------
CYGX_Mmus       -----DG----EGSQLVPT------------HIL-------D------------------
CYGF_Mmus       -----NG----KEWELRGT------------YTV-------D------------------
CYGD_Mmus       -----DA----SGEQLFAT------------HLL-------D------------------
ANPb_Mmus       -----GDL---DSGDFQPA------------AHY-------S------------------
ANPa_Mmus       -----DP----ETGAFRVV------------LNF-------N------------------
odr-1_Cele      -----NP----AEMTFESIL--------T-LKSVA-----KS-------C----------
gcy-9_Cele      -----I------NGTLKIVV--------E-LEAKN-----ND----RGQCEK--------
gcy-8_Cele      -----SP----NSDSVLPMV--------H-MEPTM-----LD----NCDGIA--------
gcy-7_Cele      -----DE----NNNNTRMA---------T--IY-------VE----N-------------
gcy-6_Cele      -----DS----NNNSSLIM---------T--VD-------VD----Q-------------
gcy-5_Cele      -----DE----KYEQVALV---------N--MTF------YN----S-------------
gcy-4_Cele      -----NS----EYDQISLI---------D--ISL------IN----D-------------
gcy-3_Cele      -----DE----QYEQTSLM---------N--LSF------AD----G-------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     -----RD-----GKAVH-VA--------N-VKPRE-----SDYCGGN-------------
gcy-23_Cele     -----PP----NSDTVRKVC--------E-LEPVM-----LT----NCDGTK--------
gcy-22_Cele     -----DS----TDKEMIVM---------Q--ITED-----LD----D-------------
gcy-21_Cele     -----FSS---SSHNSY--------SLFP-CARLA-QSS-LL------------------
gcy-20_Cele     -----NS----SLLPYMAA---------S--LL-------VN----V-------------
gcy-2_Cele      -----NS----DYEQVALA---------E--FTY------ID----P-------------
gcy-19_Cele     -----ND----KYDQASFM---------N--LTYS-----LN----G-------------
gcy-18_Cele     -----SP----NRDKVMKMV--------N-MESEL-----IS----NCDGLK--------
gcy-17_Cele     -----NS----SRLPETYG---------K--LI-------IN----N-------------
gcy-15_Cele     -----FSS---SSHNSY--------SLFP-CARLA-QSS-LL------------------
gcy-14_Cele     -----NT----SLLPYLAA---------S--LV-------IN----G-------------
gcy-13_Cele     -----DS----NATQRTVA---------Y--MD-------ID----S-------------
gcy-12_Cele     -----QKVAPIMNKSDP--------SYYP-LDHALDLTAIFV--EAP-------------
gcy-11_Cele     -----QQA----SSSNG---------PIP-LPEWATLAARM----LP-------------
gcy-1_Cele      -----NS----DYDQVALV---------D--FTY------TN----S-------------
daf-11_Cele     DVLVVDK----SLNSNNFIM--------P-LGTIS-----TD----K-KC----------
C04H5.4_Cele    ----------------VSLI--------N-STVTS-----KN----CM------------
CYGF_Hsap       -----NL----KEWELHST------------YTV-------D------------------
ANPb_Hsap       -----GDL---DSGDFQPA------------AHY-------S------------------
ANPa_Hsap       -----DP----ENGAFRVV------------LNY-------N------------------
CYGD_Hsap       -----DA----AGDRLFAT------------YML-------D------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       -----TDT---ENGTFEVV------------GNF-------Y------------------
Gcy3_Spur       -----KLG---EDVDETFGY-----IMHP-VATIK-----IT----N----STPEVEQSC
Npr3_Spur       -----TNT---EDGTFEVL------------ANY-------Y------------------
Npr4_Spur       -----NH----TDWTT------------P-LALV------PD------------------
Gcy1_Spur       -----IPI---PKGDGGA--TKDSLGMYP-IGTFN-----RE----N----GQW------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   -----VP----QSNATLPYR--------KERKGFV-----VI----C-------------
AqueK221_Aque   -----AP----STQSGVIID--------KKVGGFI-----FQ----D-------------
AqueK222_Aque   ------------------------------IAHVK-----------L-------------


HSER_Hsap       ---TH-----VNKT-YP------V-DMSPTFTWK------NSKLPNDITGRG--------
CG10738_Dmel    ----S-----SISKALP------NLKLFSPIDW------VGGTRPAAAPRCGFG------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     --N-------SVIPEFR------YIKNDRPIQW------LNGRPPLAEPLCGFH------
Gyc76C_Dmel     --G-------EEHPEY--------KLINGSIDWP-----SGGEKPADEPMCGFA------
CG4224_Dmel     ---HN-----RLE----------F-EANKEIHWA----GDREEAPPDRPICGYD------
CG3216_Dmel     ---GV-----HK--VYS------A-VHGKKIHWP----GGREEPPPDVPPCGFL------
KSGC_Mmus       ---SF-----QKVI-RP------W-RNDSNTSWP------HGSLPEYKPGCGFH------
HSER_Mmus       ---TH-----KNKT-IP------V-AENPNFIWK------NHKLPNDVPGLG--------
CYGX_Mmus       ---TS-----TWQV---------Q-PLGKPIHFP------GGSPPAHDASCWFD------
CYGF_Mmus       ---ME-----TELL---------R-FRGTPIHFP------GGRPTSADAKCWFA------
CYGD_Mmus       ---PV-----LGSL---------R-SAGTPMHFP----R-GGPAPGPDPSCWFD------
ANPb_Mmus       ---GA-----EKQI--W--------WTGRPIPWV------KGAPPLDNPPCAFD------
ANPa_Mmus       ---GT-----SQEL--M------A-VSEHRLYWP------LGYPPPDIPKCGFD------
odr-1_Cele      ---DT-----YNCFQLS------P-NKTSDLLWTL----KDMD-PPDD--CV-A------
gcy-9_Cele      ---NE-----EMCSEHV------A-HETIQYYWPS----DSGKLPPAVPKCGFT------
gcy-8_Cele      ---NK-----SGCYEIV------V-TDIMRDFWPS----VDRKMPKDEPDCGYR------
gcy-7_Cele      ---M------SATFNAL------Y-SDE-GVMWAS---RKNNARPVDVPLCGFT------
gcy-6_Cele      ---Q------EAVVTKH------Y-TNEATALWSH----RKGIRPPDQPICGYT------
gcy-5_Cele      ---SS-------QLSRG------Y-SDEGRSVWHF----WDGTRPLDTPICGFS------
gcy-4_Cele      ---TV-------NVVFN------Y-ADGNTEVWHF----WGGTRPPDTPVCGFL------
gcy-3_Cele      ---TT-----VATISLA------Y-SNESSAVWHF----WGGIRPLATPICGFL------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ---MT-----KNCYEFL---------PSS-----P----LLEDLPPYTSDCGYD------
gcy-23_Cele     ---TG-----NGCYELQ------V-TDLSTGFWPS----IDGSLPADEPACGFR------
gcy-22_Cele     ---SKDPVASSVNYYIT------L-VATPAQIWDT----WGGTVPLSTPICGFT------
gcy-21_Cele     ----------NTVWSLT------DYSEGLSIDFV------NKSAPKDTPVCGFY------
gcy-20_Cele     ---S------EVVFTPF------Y-KS-ESELWS--------VRPLSRPKCGFT------
gcy-2_Cele      ---IM-------NVTLS------Y-KEEGGAVWYF----YGNSRPLDIPICGFL------
gcy-19_Cele     ---GA-------SVSLA------Y-TNE-ASLWYW----YGGKRPLSVPVCGFA------
gcy-18_Cele     ---NK-----SGCFQLK------I-NDIKSGFWPS----EDGSMPLDEPICGYR------
gcy-17_Cele     ---Q------SVHFEQL------Y-SDEVMDVWN------GRQRPKAKPTCGFT------
gcy-15_Cele     ----------NTVWSLT------DYSEGLSIDFV------NKSAPKDTPVCGFY------
gcy-14_Cele     ---S------EVEYTPF------Y-KS-EADLWS--------VRPLARPICGFS------
gcy-13_Cele     ---T------SVNWTFA------I-IDQ-ALIWDA----YNGKLPQTRPECGYS------
gcy-12_Cele     ---DK-----DRLPNL-------QFK-SSRIQWL------KGEPPPDEPVCGFH------
gcy-11_Cele     ---DG-----KGNYSI-------IWKNLTQLGIF------NGELPQSKPECGFN------
gcy-1_Cele      ---VM-----VPNVTLF------Y-KDEGGAVWSY----YGHSRPLDIPICGFL------
daf-11_Cele     ---PD-----QACLNFV------L-NS-------T----SSFEPLKDVPLCGFH------
C04H5.4_Cele    ----D-----PVCIELV------V-SDVVTKFWSS----PSGKLPDSEPECGFR------
CYGF_Hsap       ---ME-----MELL---------R-FGGTPIHFP------GGRPPRADAKCWFA------
ANPb_Hsap       ---GA-----EKQI--W--------WTGRPIPWV------KGAPPSDNPPCAFD------
ANPa_Hsap       ---GT-----SQEL--V------A-VSGRKLNWP------LGYPPPDIPKCGFD------
CYGD_Hsap       ---PA-----RGSF---------L-SAGTRMHFP----R-GGSAPGPDPSCWFD------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       --------------------------------------------PPDTPKCGFE------
Npr2_Spur       ---LT-----SSGLKYT------P-VPGKPIKWP----GGATSPPRDTPFCGFN------
Gcy3_Spur       LGNGT-----SFQWVYE------P-INGTFIPW------ISGSVPLAVPTCGFY------
Npr3_Spur       ---GE-----TGVI---------E-TTGVKPVWP----GGGIGPPRDAPECGFE------
Npr4_Spur       ---GV-----TSII-----------AHIRIGNWQAALHHIVTVRPR--SECGNKNCEELE
Gcy1_Spur       ----------GFEEALD------EDANVLRPVWH-----NRDEPPLDMPPCGFH------
Gcy2_Spur       ---------------YA------A-HKGVDIQW------LGGSPPRAQPVCGFD------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ---QN-----EPLIEFIDSSTGLK-SDVSTIVFH----NGLTAIPSDSISKFY-------
AqueK221_Aque   ---PE-----NSRILFYHNNETLS--PVNGLIFK----DGTTSVPLDYHQRKY-------
AqueK222_Aque   --G-------EMQMAIQ-------KSIYVTDHY------CGDGRCSDSEDCSSC------


HSER_Hsap       -----------PQ----IL---MIAVFTLT--G----AVVL--LLL---V-A--------
CG10738_Dmel    GEK---CVN-Y---T--------GEISAAIA-G-G--ALLL--LSL---V-S--------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     GEL---CPRKK---L-DW-----RYLVSGPL-C-A--LVVV--V-A---I-A--------
Gyc76C_Dmel     NEL---CKKDD---T-HY----TSTVAAVVL-G-V--LLFC--SGV---I-T--------
CG4224_Dmel     GAL---CPDN---SL-P-----GYAILSIVL-G-T--MVVV--MAV---C-F--------
CG3216_Dmel     GNS-TDCVGN---FT-P-----RS----------I--NIL---F-I---Y-T--------
KSGC_Mmus       NDL---CKTKPPTVA-GSM---TVTVTAVIP-T-V--TFLV--LASAAAITG--------
HSER_Mmus       -----------PQ----IL---MIAVFTLT--G----ILVV--LLL---I-A--------
CYGX_Mmus       PNT--LCIRG---VQ-PLG---S--LLTLTI-A-C--VLAL--VGG---F-L--------
CYGF_Mmus       ERK--ICQGG---ID-PAL---A-MMVCFAL-L-I--ALLS--ING---F----------
CYGD_Mmus       PDV--ICNGG---VE-PGL-----VFVGFLL-V-I--GMGL--TGA---F-L--------
ANPb_Mmus       LDD-PSCDKT---PL-S-----TLAIVALGT-G-V--TFIM--FGV---S-S--------
ANPa_Mmus       NED-PACNQD---HF-S-----TLEVLALVG-S-L--SLVS--FLI---V-S--------
odr-1_Cele      KSS---CVN--------YI---PHIIAA-VV-I-V--TIIV--IA----I-V--------
gcy-9_Cele      GAE---CD---------YR---PYFIGA-SL-L-A--FILT--VGP---L-S--------
gcy-8_Cele      NER---CD---------YT---LIIIGA-AL-I-L--LFIV--AAV---S-A--------
gcy-7_Cele      GNL---CPKSF--VD-EYL---IWVIVAIVV-L-F--LAIT--AAA---CGI--------
gcy-6_Cele      GSL---CPANV--FF-QYI---GWFIAAIII-I-F--FTIM--GAI---LAF--------
gcy-5_Cele      GRY---CPVQF--WD-QYG---VLIFVASIV-L-I--FLIC--IML---MCF--------
gcy-4_Cele      GKS---CPLPI--FE-QYR---ALVIVAIAV-T-I--LILL--AII---ICM--------
gcy-3_Cele      GNS---CPLPF--WE-QYG---ILIFVGAGV-F-L--IMIT--TNL---ICF--------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     NNL---CSDF--------H---VFMIAA-IV-F-S--ILLI--PMA---I-A--------
gcy-23_Cele     NEK---CD---------YT---TLIIGG-CI-V-L--LIIL--LII---C-F--------
gcy-22_Cele     GTD---CPKSF--TD-QYL---AIILGCTAA-A-L--VLII--AVI---STI--------
gcy-21_Cele     GEN---CGPPA---N-NTF----IIVISVGV---A--VLIG--LAI---A-A--------
gcy-20_Cele     GLE---CPADF--VK-EYL---VYTIIAAFI-V-I--LALL--AGC---AGL--------
gcy-2_Cele      GKF---CPISF--WE-QYM---ILAIVSISV-I-V--LMVI--IMI---IGC--------
gcy-19_Cele     GTD---CPQSF--VD-QYG---ALVFAIGGV-L-I--FAML--FVI---TCF--------
gcy-18_Cele     GQR---CS---------YL---LEISVG-SL-I-I--LLIL--ISV---V-F--------
gcy-17_Cele     GTQ---CPPDF--VR-DYL---VIVIIIVMF-L-I--FAVS--AAV---GAV--------
gcy-15_Cele     GEN---CGPPA---N-NTF----IIVISVGV---A--VLIG--LAI---A-A--------
gcy-14_Cele     GLE---CPPDF--VK-EYL---VYTIIAAVI-V-V--LALL--AGC---AGLLYTMQQKI
gcy-13_Cele     GKS---CPVNF--FV-DYL---YIVVIVAVI-I-V--LCCA--AAA---IAA--------
gcy-12_Cele     GEN---CRKKG---I-FSY----LTVVVMIL---I--AVFS--LVL---TGF--------
gcy-11_Cele     NEL---CPAGI---P-ESE----PSSFFDFS---K--NLY---LKK----RV--------
gcy-1_Cele      GKS---CPVSF--WE-QYK---ILIFVAIAV-I-V--LMVL--IMI---IGC--------
daf-11_Cele     GEI---CD---------QT---GVIIAIAVI-M-G--VLLM--FII---I-L--------
C04H5.4_Cele    EEN---CD---------YT---QTIVIA-TA-V-V--CIIL--TVF---L-G--------
CYGF_Hsap       EGK--ICHGG---ID-PAF---A-MMVCLTL-L-I--ALLS--ING---F----------
ANPb_Hsap       LDD-PSCDKT---PL-S-----TLAIVALGT-G-I--TFIM--FGV---S-S--------
ANPa_Hsap       NED-PACNQD---HL-S-----TLEVLALVG-S-L--SLLG--ILI---V-S--------
CYGD_Hsap       PNN--ICGGG---LE-PGL-----VFLGFLL-V-V--GMGL--AGA---F-L--------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       NEL---CPAT---DN-S-KSKPSIKSLGVLG-RVLTSRFVN--TYL---F-F--------
Npr2_Spur       NEN-PECQPDG--RL-S-----TLAISGIAA-A-S--VLLL--SFL---I-L--------
Gcy3_Spur       GEF---CDTPY---R-PI-----VEIVSGVV-G-G--LLLV--ILI---V-A--------
Npr3_Spur       NEL---CQSN---EL-P-----ILGLVGIAA-V-V--VVLA--AAG---I-L--------
Npr4_Spur       GETCSNCPADC--GRCPLS---IGALSGIIA-G-C--IVVV--GSF---C-C--------
Gcy1_Spur       GEL---CTNW----A--------LYLGASIP-T-F--LIIF--GGL---I-G--------
Gcy2_Spur       GSL---CKTNY---T--------IHIVAGVI-A-G--IIML--TAI---I-A--------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   --------------T-RNN---RVIVGCLIL-E-L--VLYL--IMS---L-L--------
AqueK221_Aque   --------------R-R-S---TSLTGAIVFNS-S--FLYI--LIA---V-C--------
AqueK222_Aque   SVD---CCASL---P-SY----VVALSSSLS-S-V--IFLAIGLTI---I-L--------


HSER_Hsap       ---------------------------------------------------LL-MLRKY-
CG10738_Dmel    ---------------------------------------------------LV-LYRNW-
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ----------------------------------------------------L-LIKHY-
Gyc76C_Dmel     ---------------------------------------------------MS-IYRKW-
CG4224_Dmel     ---------------------------------------------------FF-GYRHY-
CG3216_Dmel     ---------------------------------------------------GT-DFRQM-
KSGC_Mmus       ---------------------------------------------------LM-LWRLRG
HSER_Mmus       ---------------------------------------------------LL-VLRKY-
CYGX_Mmus       ---------------------------------------------------AY-FIRL-G
CYGF_Mmus       ---------------------------------------------------AY-FIRR-R
CYGD_Mmus       ---------------------------------------------------AH-YLRH-R
ANPb_Mmus       ---------------------------------------------------FL-IFRKL-
ANPa_Mmus       ---------------------------------------------------FF-IYRKM-
odr-1_Cele      ----------------------------------------------------I-IVKQR-
gcy-9_Cele      ----------------------------------------------------Y-FIYLK-
gcy-8_Cele      ----------------------------------------------------F-FAQKI-
gcy-7_Cele      ---------------------------------------------------YF-SIQAR-
gcy-6_Cele      ---------------------------------------------------IY-LCHAK-
gcy-5_Cele      ---------------------------------------------------GF-MIRGR-
gcy-4_Cele      ---------------------------------------------------SS-KIRNR-
gcy-3_Cele      ---------------------------------------------------LF-MIKNR-
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ---------------------------------------------------FY-L---Q-
gcy-23_Cele     ----------------------------------------------------F-ILSRV-
gcy-22_Cele     ---------------------------------------------------VF-LVRSK-
gcy-21_Cele     ---------------------------------------------------AF-LYKRY-
gcy-20_Cele     ---------------------------------------------------LY-TMHMK-
gcy-2_Cele      ---------------------------------------------------LC-VISAK-
gcy-19_Cele     ---------------------------------------------------FY-VMRQK-
gcy-18_Cele     ----------------------------------------------------F-FLFRY-
gcy-17_Cele     ---------------------------------------------------FY-AIRQK-
gcy-15_Cele     ---------------------------------------------------AF-LYKRY-
gcy-14_Cele     SLKMDNFKILIMVKNTNFLKVEERKYTYAYGIAMAKSRKLKSQVFPFSITLLL-NFRMK-
gcy-13_Cele     ---------------------------------------------------FL-VIKAR-
gcy-12_Cele     ---------------------------------------------------TLNYIRSR-
gcy-11_Cele     ---------------------------------------------------VLKWI----
gcy-1_Cele      ---------------------------------------------------LC-VISGK-
daf-11_Cele     ----------------------------------------------------T-TIRKCC
C04H5.4_Cele    ----------------------------------------------------I-WLRRA-
CYGF_Hsap       ---------------------------------------------------AY-FIRR-R
ANPb_Hsap       ---------------------------------------------------FL-IFRKL-
ANPa_Hsap       ---------------------------------------------------FF-IYRKM-
CYGD_Hsap       ---------------------------------------------------AH-YVRH-R
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ---------------------------------------------------IS-ICRKY-
Npr2_Spur       ---------------------------------------------------VL-VYRKI-
Gcy3_Spur       ---------------------------------------------------IT-VYRNW-
Npr3_Spur       ---------------------------------------------------FV-IYRKH-
Npr4_Spur       ---------------------------------------------------VI-GYFYW-
Gcy1_Spur       ---------------------------------------------------FF-IYRKR-
Gcy2_Spur       ---------------------------------------------------TI-VYRNW-
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ---------------------------------------------------YI-IYVNKV
AqueK221_Aque   ---------------------------------------------------YF-VYVRHQ
AqueK222_Aque   ---------------------------------------------------FI-VWFYY-


HSER_Hsap       R-KDYELRQKKWSH-IPPENIFPLETNE-TNH------V-SL------------------
CG10738_Dmel    R-YEQELDSLLWK--IDFREVQIHENER-EQQ---S-QK-QT-RSTH--------PLI-R
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     R-YEQTLAGLLWK--VDMKDVTVINLGE-YNNP--T-NK-NI-F-----------QIC-R
Gyc76C_Dmel     K-IELEIEGLLWK--IDPNEIKGYSGNE-IVSS-----P-SK-VSLM--------S---A
CG4224_Dmel     I-AEAEINSMSWK--VSLEDVMFRDAAE-RG----L-RG-SF-HSLV--------K-Q-S
CG3216_Dmel     K-LSKELNNMSWR--VRPDDVLIEMGGM-FG-S--K-GGLQR-LDVENISLQQFGI-H-S
KSGC_Mmus       K-VQSHPGDTWWQ--IRYDSITLLPQHK-LSHR--GTPV-SR-RNVS--------D-T-S
HSER_Mmus       R-RDHALRQKKWSH-IPSENIFPLETNE-TNH------I-SL------------------
CYGX_Mmus       L-QQLRLLRGPHRILLTSQELTFLQRTPSRRRPHVD-SG-SE-S-RS-------------
CYGF_Mmus       I-NKIQLIKGPNRILLTLEDVTFINPHFGSKR------G-SR-ASVS--------F-Q-I
CYGD_Mmus       L-LHMQMASGPNKIILTLEDVTFLHPPGGSSRK-VV-QG-SR-SSLA--------T-R-S
ANPb_Mmus       M-LEKELASMLWR--IRWEELQFGNSDR-YH-K--G-AG-SR-LTLS--------L-R-G
ANPa_Mmus       Q-LEKELVSELWR--VRWEDLQPSSLER-HL-R--S-AG-SR-LTLS--------G-R-G
odr-1_Cele      R-HKLNIYKLTWK--VPKESLKIIVNKN-AD------AK-MQ-REL-E-------N-R-A
gcy-9_Cele      Q-KERLLYDMTWR--IPRESIKMLEGKS-KS------EH-----SL-A-------S-K-S
gcy-8_Cele      L-EKRALDKLPFR--IYRDDLQFIDEEQ-LK---------SM-LSL-G-------S-T-R
gcy-7_Cele      R-QEIERLNRLWQ--IPFIHLHQINSKQ-KGK---G-EH-SV-RSL-Q-------S-G-T
gcy-6_Cele      Q-QEVERQNALWQ--IPFKSMMTVTKKG---K---G-EH-SM-RSI-S-------S-V-P
gcy-5_Cele      R-AEQERLNSEWQ--IPSIQLIMPQKEK-R-----K-PN-SR-RSL-Q-------S-G-P
gcy-4_Cele      R-VEQSRLHSEWQ--IHAIKLRLPMHRR-A-----S-KS-SQ-ESETE-------S-A-S
gcy-3_Cele      R-EEQARINSEWQ--IPFVKLRELERK---S----K-GT-SK-RSL-Q-------S-A-P
gcy-27_Cele     ----TRKYKMTWK--VPKESLKIIVNKN-AD------AR-MQ-REL-E-------N-R-T
gcy-25_Cele     R-KEHLIQQMPWR--VPLDSISFDDNGG-SL-S-----A-S--RRV-S-------T-I-S
gcy-23_Cele     C-ENRALANTPWR--IYRDDFRTIQENE-MK---------SM-LSI-G-------S-S-K
gcy-22_Cele     R-QEEERLNQLWQ--VHFSSLVKPPQKN-T-------MH-SS-RSL-Q-------S-T-V
gcy-21_Cele     R-YERRLHSLFFM--IDRNQIILKKHTN-L-MS----QQ-SL-RSMA--------S----
gcy-20_Cele     R-KEMERQDLLWQ--VAFVELQQVQSKS---R---A-EA-SM-HSF-A-------S-G-P
gcy-2_Cele      H-AEQARTNAEWQ--VPFVNLMESEKQI-RS----N-AT-SR-RSL-Q-------S-A-P
gcy-19_Cele     R-LERDRIDAEWQ--IPLVKLQAPPKRD-K-----E-RM-SK-RSL-Q-------S-G-P
gcy-18_Cele     C-ENKQLEKMPWR--IFHDDLQFIDEEQ-VK---------SM-MSV-G-------S-V-T
gcy-17_Cele     R-KEIERQDELWH--VEASHLKPISKKS---K---S-EA-SQ-RSF-A-------S-G-P
gcy-15_Cele     R-YERRLHSLFFM--IDRNQIILKKHTN-L-MS----QQ-SL-RSMA--------S----
gcy-14_Cele     R-KEMERQDLLWQ--VPFIELQQVQSKS---K---A-EA-SM-HSF-A-------S-G-P
gcy-13_Cele     R-DEELRLDDQWI--VPHGMLQSIIKGR-K-E---S-HH-SS-RSL-Q-------S-N-S
gcy-12_Cele     R-FEKEL-SMIWK--IDPYEVRRVVGGV-NNES----TA-SLMQSDV--------M-QFA
gcy-11_Cele     A-YERRLESSYFL--VHRKHVQLVDMTK-FGSS--R-GG-SMIQSAM--------S----
gcy-1_Cele      R-AERARINAEWQ--VPFAKLIESEKQV-RG----K-GA-SR-RSL-Q-------S-A-P
daf-11_Cele     NGSKGRSISNPWV--IPFQDVRFIDLTN-TE------GS-QH-MSI-Q-------S-L-Q
C04H5.4_Cele    C-ETSALDKMPWR--VFRDDVQILDEEQ-VK---------SV-VSL-N-------S-A-S
CYGF_Hsap       I-NKIQLIKGPNRILLTLEDVTFINPHFGSKR------G-SR-ASVS--------F-Q-I
ANPb_Hsap       M-LEKELASMLWR--IRWEELQFGNSER-YH-K--G-AG-SR-LTLS--------L-R-G
ANPa_Hsap       Q-LEKELASELWR--VRWEDVEPSSLER-HL-R--S-AG-SR-LTLS--------G-R-G
CYGD_Hsap       L-LHMQMVSGPNKIILTVDDITFLHPHGGTSRK-VA-QG-SR-SSLG--------A-R-S
T01A4.1_Cele    -----------------------------------------------KLSFGMVSF-K-S
Npr1_Spur       R-LERELSNMSWR--IRWEDISFNNKGD-KM-R--K-LG-SR-MSLA--------S-G-S
Npr2_Spur       R-LDAELLRMSWK--LSWDELVFPEETK-SG-Q--S-KF-SG--SFV------------T
Gcy3_Spur       K-YEQELASLLWK--IDYADIQTKRHN----G---S-TI-SA-ISKL-------------
Npr3_Spur       R-LDAELMSMSWK--VAWEELIFEEIGK-SV-A--T-AT-SG--SRA--------L---S
Npr4_Spur       R-QEKMFWDESWI--INYEDIKPDTGQR-G-----F-GG-SV-ISI-R-------G-D-C
Gcy1_Spur       A-YEAALDSLVWK--VDWSEVQTKATDT-NSQG-----F-SM-KN-----------MV-M
Gcy2_Spur       R-YEQALASLLWK--IDYNELEFKSIC---HG---S-RL-SI-ATHD-------------
Npr5_Spur       --------------------------------------------S-----------TV--
AqueK220_Aque   D-KRANVYNESWI--YHDNDISYSIDQS-GV-N-----------IM-L------------
AqueK221_Aque   D-KLAHIYSEAWL--YQQKDVKLTTGTF-AD-S-----------TL-S------------
AqueK222_Aque   Q-KQKLFYDESWI--IDYSDLRLCSMMS-LINS-----R-IH-GETD--------N---V


HSER_Hsap       ----------KIDDD------K--------------------------------------
CG10738_Dmel    TS--------QVS--LSSNPDA--------------------------------------
CG9783_Dmel     -------KS--GSSATGSLA----------------------------------------
Gyc32E_Dmel     QS--------ILV--------V--------------------------------------
Gyc76C_Dmel     QS-------------YGSRW----------------------------------------
CG4224_Dmel     SQ---------LTLMSEDMVSI--------------------------------------
CG3216_Dmel     GR---------AS--IASF--T--------------------------------------
KSGC_Mmus       TV--------KASADCGSLVKR--------------------------------------
HSER_Mmus       ----------KIDDD------R--------------------------------------
CYGX_Mmus       ---VVDGGSP-RSVTQGSARS---------------------------------------
CYGF_Mmus       ISEVQSGRSPRLSFSSGSL-----------------------------------------
CYGD_Mmus       ASDIRS------------V-----------------------------------------
ANPb_Mmus       SS-------------YGSLMTA--------------------------------------
ANPa_Mmus       SN-------------YGSLLTT--------------------------------------
odr-1_Cele      SN----------T-DNAAALTS--------------------------------------
gcy-9_Cele      QS----------SGSFSGSMNS--------------------------------------
gcy-8_Cele      TK-----------M---SNMNY--------------------------------------
gcy-7_Cele      S-----------TLSSR--TTV--------------------------------------
gcy-6_Cele      S-----------TISSTRSSTL--------------------------------------
gcy-5_Cele      S-----------TITGESKMTI--------------------------------------
gcy-4_Cele      ET---------ENFTSKSGDTM--------------------------------------
gcy-3_Cele      S-----------TITGESKVST--------------------------------------
gcy-27_Cele     A-----------K-DEANALTS--------------------------------------
gcy-25_Cele     TA--------RAS--YSSIF----------------------------------------
gcy-23_Cele     TK-----------M---SNMSM--------------------------------------
gcy-22_Cele     T-----------TST-K--VTI--------------------------------------
gcy-21_Cele     -I--------HGSVVAASQTLRDS-HFFIEDYNNASSINASSIFNTGSTARAGPFGPIPG
gcy-20_Cele     S-----------TST-K--MTV--------------------------------------
gcy-2_Cele      S-----------ISTGHSGVTT--------------------------------------
gcy-19_Cele     S-----------NITDTSKMTF--------------------------------------
gcy-18_Cele     TK-----------L---SNIQT--------------------------------------
gcy-17_Cele     S-----------TST-K--LTV--------------------------------------
gcy-15_Cele     -I--------HGSVVAASQTLRDS-HFFIEDYNNASSINASSIFNTGSTARAGPFGPIPG
gcy-14_Cele     S-----------TST-K--ITV--------------------------------------
gcy-13_Cele     T-----------TTTG--TTGI--------------------------------------
gcy-12_Cele     KT--------KTPWWSKAPVQG--------------------------------------
gcy-11_Cele     -M--------RSQYEDSGPVGGATMNFYTNG------IRKAAIR------R-NQ----MQ
gcy-1_Cele      S-----------ISTGHSGVTT--------------------------------------
daf-11_Cele     RN-----------MEEKQRLQS--------------------------------------
C04H5.4_Cele    TK-----------M---SQVET--------------------------------------
CYGF_Hsap       TSEVQSGRSPRLSFSSGSL-----------------------------------------
ANPb_Hsap       SS-------------YGSLMTA--------------------------------------
ANPa_Hsap       SN-------------YGSLLTT--------------------------------------
CYGD_Hsap       MSDIRS------------G-----------------------------------------
T01A4.1_Cele    GS--------GGS--VETI--A--------------------------------------
Npr1_Spur       VE-------------SGTS-VW--------------------------------------
Npr2_Spur       S--------------IGHG--T--------------------------------------
Gcy3_Spur       -S--------LMT--TDSKNSV--------------------------------------
Npr3_Spur       SK---------RS--MNEE--I--------------------------------------
Npr4_Spur       DT--------SAS-SVSGFVHT--------------------------------------
Gcy1_Spur       -S--------AIS--VIS------------------------------------------
Gcy2_Spur       -S--------RVS--M--YADP--------------------------------------
Npr5_Spur       -S--------VKG--KDA------------------------------------------
AqueK220_Aque   -----------------SWLTY--------------------------------------
AqueK221_Aque   -----------------SLLQI--------------------------------------
AqueK222_Aque   SG-------------QGSVF-N--------------------------------------


HSER_Hsap       ----------RR--DT---IQRLRQC----K--YDKKRVILKDLK-----HND--G--NF
CG10738_Dmel    ----------DFR-YT---TIFTPIG----L--YKGQLYAIKKVRK-----KS--V--DI
CG9783_Dmel     ----------R-H-NP---AHLDMRA----R--YNGDLVQLKEVNIN----GS----AEL
Gyc32E_Dmel     ----------GEP-NK---RSFTNIA----L--FRGNIVAMKKIHK-----KS--V--DI
Gyc76C_Dmel     --------------TN---QFVTSTG----R--LRGAVVRIKELKFP---R-K--R--DI
CG4224_Dmel     ----------N-G-DR---QIFIPVG----M--FRKSKVAIKPVE-----VDN--VQGLL
CG3216_Dmel     ----------S-L-PP---QVYTTIG----Q--FKGERVAIKKVN-----VKK--V--DL
KSGC_Mmus       ----------HQD-EE---LFFAPVG----L--YQGNQVALCYIG-----DEA--E--AW
HSER_Mmus       ----------RR--DT---IQRVRQC----K--YDKKKVILKDLK-----HSD--G--NF
CYGX_Mmus       ----------L-P-AF---LEHTNVA----L--YQGEWVWLKKFEAG----VA----PDL
CYGF_Mmus       ----------T-P-AT---YENSNIA----I--YEGDWVWLKKFPPG----DFGDI-KSI
CYGD_Mmus       ----------P-S-QP---QESTNVG----L--YEGDWVWLKKFPGE----HH----MAI
ANPb_Mmus       ----------H-G-KY---QIFANTG----H--FKGNVVAIKHVN-----KKR--I--EL
ANPa_Mmus       ----------E-G-QF---QVFAKTA----Y--YKGNLVAVKRVN-----RKR--I--EL
odr-1_Cele      ----------RRR-VF---GSYALVG----T--QRAEYVQFKQI-------RK--I--NF
gcy-9_Cele      ----------KQN-GL----IAAKQA----V--SNGVKLAIKRYQQ----VRN--I--TF
gcy-8_Cele      ----------G----S---RNHAIVG----T--NTH-AIYH-KYVQ----RRP--I--VF
gcy-7_Cele      ----------SFKT----ESRNFLFFSLQRE--SDYEPVVAKKHA------YR--P--RL
gcy-6_Cele      ----------SEVG----ETRNYLFFQIQND--VEMERVAAKKHS------IR--M--VF
gcy-5_Cele      ----------DG--GF---HENYTVQ----M--FEKDLVLTTKHH-------S--M--QM
gcy-4_Cele      ----------TS--EF---KETYTIQ----Y--LENDLVLTTAHQ-------V--Q--EL
gcy-3_Cele      ----------GS--EF---CENYEVK----M--FEKDMVLTMKFQ-------Y--M--NL
gcy-27_Cele     ----------RRR-VF---GSYALIG----T--QRAEFIQFRQI-------KH--I--DI
gcy-25_Cele     -----------SG-----N--VAEHA----I--VNKQKVSVKRHVQ----RRA--I--TF
gcy-23_Cele     ----------F----V---KHHAVVG----T--NTH-ASFH-LYPQ----RRP--I--VF
gcy-22_Cele     ----------NSKK----DTERHSFY----F--LNNDSVVARKHN------FR--A--TF
gcy-21_Cele     FGGVTG-ASEDEKWHQ---IPDFGVG----L--YEGRTVALKRIY-----RSD--V--EF
gcy-20_Cele     ----------ESRT----ETTNFIFY----H--YHQEVVAAKKHD------LL--V--LF
gcy-2_Cele      ----------VS--DF---CENYTMM----M--YEKEMVLTAKYQ-------Y--T--HL
gcy-19_Cele     ----------DN--TF----SNYSIF----Y--LDKEPVLSTAHP-------A--S--NL
gcy-18_Cele     ----------G----Q---KQHAIIG----V--NTH-TTYH-RYKQ----RRP--I--KF
gcy-17_Cele     ----------ESRT----ETTRFIFY----I--YQNEVVAANKHD------FR--P--QL
gcy-15_Cele     FGGVTG-ASEDEKWHQ---IPDFGVG----L--YEGRTVALKRIY-----RSD--V--EF
gcy-14_Cele     ----------ESRS----ETINFIFY----Y--YQQDILAAMKHD------LI--L--QF
gcy-13_Cele     ----------SSRSVFFPETETQGYF----V--YMNEPVLARKYQ------LR--V--PI
gcy-12_Cele     -------------------TGMRGLA----S--YKGTLVGLKDLMYG---RKP--K--DL
gcy-11_Cele     -RSDKGPAANRDEWLE---IVDWHLA----K--YENTLVTVRKIN-----KTQ--L--KL
gcy-1_Cele      ----------VS--DF---CENYTMM----M--YEKEMVLTAKYQ-------Y--T--HL
daf-11_Cele     ----------LAR--------TKHIA----T--VDQVYVLADKYVM----RDK--L--RY
C04H5.4_Cele    ----------K---LI---KNHAIVG----V--NTH-AVYD-LYEQ----RQN--I--RF
CYGF_Hsap       ----------T-P-AT---YENSNIA----I--YEGDWVWLKKFSLG----DFGDL-KSI
ANPb_Hsap       ----------H-G-KY---QIFANTG----H--FKGNVVAIKHVN-----KKR--I--EL
ANPa_Hsap       ----------E-G-QF---QVFAKTA----Y--YKGNLVAVKRVN-----RKR--I--EL
CYGD_Hsap       ----------P-S-QH---LDSPNIG----V--YEGDRVWLKKFPGD----QH----IAI
T01A4.1_Cele    ----------Q-N-NT---QIYTKTA----I--FKGVVVAIKKLNIDPKKYPR--L--DL
Npr1_Spur       ----------G-N-NQ---QIFTVTG----F--YKGNVIAIKRVN-----RQR--V--EL
Npr2_Spur       ----------S-H-HR---QMFATVA----N--YKGRLVVIRRIE-----KTK--L--DL
Gcy3_Spur       ----------DPY-RC---QIFTEVG----T--YKNMLVAIKKIHK-----RH--V--DL
Npr3_Spur       ----------Q-D-GG---QIFATVA----R-----------------------------
Npr4_Spur       ----------A-H-HK---QVFAQTG----I--YNGQTVAVKMIA-----KNS--F--TL
Gcy1_Spur       ----------NAE-KQ---QIFATIG----T--YRGTVCALHAVHK-----NH--I--DL
Gcy2_Spur       ----------LSG-RG---QVFTRVG----R--YNHTLVAIKPVHK-----KH--I--EM
Npr5_Spur       ----------N-K-KG---K-NFAFA----T--YNSHTVVLRKVEV-----HD--F--NL
AqueK220_Aque   -----------NG-D-------QTIG----QINNAGNAVYIHKAK-----LNM--S--QL
AqueK221_Aque   ----------LQP-NL---QEDSNIG----E--INGKIVKVHKMK-----MNI--S--TL
AqueK222_Aque   ----------LNG-NR---QIFIPTG----V--YEGKTVAIKKLNYR---SRE--L--QL


HSER_Hsap       --T---------------------------------------------------------
CG10738_Dmel    --T---------------------------------------------------------
CG9783_Dmel     --R---------------------------------------------------------
Gyc32E_Dmel     --T---------------------------------------------------------
Gyc76C_Dmel     --S---------------------------------------------------------
CG4224_Dmel     --T---------------------------------------------------------
CG3216_Dmel     --T---------------------------------------------------------
KSGC_Mmus       VKK---------------------------------------------------------
HSER_Mmus       --S---------------------------------------------------------
CYGX_Mmus       --R---------------------------------------------------------
CYGF_Mmus       --K---------------------------------------------------------
CYGD_Mmus       --R---------------------------------------------------------
ANPb_Mmus       --T---------------------------------------------------------
ANPa_Mmus       --T---------------------------------------------------------
odr-1_Cele      --P---------------------------------------------------------
gcy-9_Cele      --P---------------------------------------------------------
gcy-8_Cele      --N---------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      --DN--------------------------------------------------------
gcy-5_Cele      --N---------------------------------------------------------
gcy-4_Cele      --S---------------------------------------------------------
gcy-3_Cele      --N---------------------------------------------------------
gcy-27_Cele     --T---------------------------------------------------------
gcy-25_Cele     --S---------------------------------------------------------
gcy-23_Cele     --N---------------------------------------------------------
gcy-22_Cele     --T---------------------------------------------------------
gcy-21_Cele     --T---------------------------------------------------------
gcy-20_Cele     --D---------------------------------------------------------
gcy-2_Cele      --T---------------------------------------------------------
gcy-19_Cele     --I---------------------------------------------------------
gcy-18_Cele     --I---------------------------------------------------------
gcy-17_Cele     --TDVERSELRQVWPRDEMVTSHLFHYARRKVTSHVRHFVIFWHFHSKKLTTRGRRDFRA
gcy-15_Cele     --T---------------------------------------------------------
gcy-14_Cele     --D---------------------------------------------------------
gcy-13_Cele     --F---------------------------------------------------------
gcy-12_Cele     --T---------------------------------------------------------
gcy-11_Cele     --T---------------------------------------------------------
gcy-1_Cele      --T---------------------------------------------------------
daf-11_Cele     --D---------------------------------------------------------
C04H5.4_Cele    --T---------------------------------------------------------
CYGF_Hsap       --K---------------------------------------------------------
ANPb_Hsap       --T---------------------------------------------------------
ANPa_Hsap       --T---------------------------------------------------------
CYGD_Hsap       --R---------------------------------------------------------
T01A4.1_Cele    --S---------------------------------------------------------
Npr1_Spur       --N---------------------------------------------------------
Npr2_Spur       --T---------------------------------------------------------
Gcy3_Spur       --T---------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       --D---------------------------------------------------------
Gcy1_Spur       --T---------------------------------------------------------
Gcy2_Spur       --S---------------------------------------------------------
Npr5_Spur       --T---------------------------------------------------------
AqueK220_Aque   --N---------------------------------------------------------
AqueK221_Aque   --D---------------------------------------------------------
AqueK222_Aque   --T---------------------------------------------------------


HSER_Hsap       -----------------------------------------------EKQKI--------
CG10738_Dmel    -----------------------------------------------REMKK--------
CG9783_Dmel     -----------------------------------------------TKAMD--------
Gyc32E_Dmel     -----------------------------------------------RSIRK--------
Gyc76C_Dmel     -----------------------------------------------REIMK--------
CG4224_Dmel     -----------------------------------------------RSLML--------
CG3216_Dmel     -----------------------------------------------PQLLW--------
KSGC_Mmus       -----------------------------------------------PTVRR--------
HSER_Mmus       -----------------------------------------------EKQKI--------
CYGX_Mmus       -----------------------------------------------PSSLS--------
CYGF_Mmus       -----------------------------------------------SSASD--------
CYGD_Mmus       -----------------------------------------------PATKT--------
ANPb_Mmus       -----------------------------------------------RQVLF--------
ANPa_Mmus       -----------------------------------------------RKVLF--------
odr-1_Cele      -----------------------------------------------ETTLD--------
gcy-9_Cele      -----------------------------------------------KSELR--------
gcy-8_Cele      -----------------------------------------------RADKTLIQLAKNF
gcy-7_Cele      ----------------------------------------------DDDKCT--------
gcy-6_Cele      ---------------------------------------------KTCATMR--------
gcy-5_Cele      -----------------------------------------------KEEKE--------
gcy-4_Cele      -----------------------------------------------QAEMM--------
gcy-3_Cele      -----------------------------------------------KADMD--------
gcy-27_Cele     -----------------------------------------------NASLD--------
gcy-25_Cele     -----------------------------------------------RQEME--------
gcy-23_Cele     -----------------------------------------------RQDLQ--------
gcy-22_Cele     -----------------------------------------------KNDRA--------
gcy-21_Cele     -----------------------------------------------RSIRL--------
gcy-20_Cele     -----------------------------------------------ANQKS--------
gcy-2_Cele      -----------------------------------------------KADKE--------
gcy-19_Cele     -----------------------------------------------RTDYD--------
gcy-18_Cele     -----------------------------------------------KEDMQ--------
gcy-17_Cele     CLKPARLTPAFRLFSTFLCFVEAGGGLLKVRQIGVLTPTSMPYLKPKLSYFS--------
gcy-15_Cele     -----------------------------------------------RSNRL--------
gcy-14_Cele     -----------------------------------------------AEQKA--------
gcy-13_Cele     -----------------------------------------------KQDRS--------
gcy-12_Cele     -----------------------------------------------REAKK--------
gcy-11_Cele     -----------------------------------------------REMKQ--------
gcy-1_Cele      -----------------------------------------------KADKE--------
daf-11_Cele     -----------------------------------------------KIDIN--------
C04H5.4_Cele    -----------------------------------------------REDLI--------
CYGF_Hsap       -----------------------------------------------SRASD--------
ANPb_Hsap       -----------------------------------------------RQVLF--------
ANPa_Hsap       -----------------------------------------------RKVLF--------
CYGD_Hsap       -----------------------------------------------PATKT--------
T01A4.1_Cele    -----------------------------------------------RAQLM--------
Npr1_Spur       -----------------------------------------------RNVLM--------
Npr2_Spur       -----------------------------------------------REVLK--------
Gcy3_Spur       -----------------------------------------------RSVRK--------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       -----------------------------------------------KRIRK--------
Gcy1_Spur       -----------------------------------------------RAVRT--------
Gcy2_Spur       -----------------------------------------------R------------
Npr5_Spur       -----------------------------------------------KAIKR--------
AqueK220_Aque   -----------------------------------------------VKMRQ--------
AqueK221_Aque   -----------------------------------------------LNLRK--------
AqueK222_Aque   -----------------------------------------------KTLRK--------


HSER_Hsap       --------------------ELNKLL-QIDYYNLTKFYGTVKLD----------TMI-FG
CG10738_Dmel    --------------------ELKLLR-DARHDNICAFIGACTDPP----------NI-CI
CG9783_Dmel     --------------------LLVMAH-GLRHENINPLIGWLSDP----------NRT-AM
Gyc32E_Dmel     --------------------ELKLMR-EVRHENIINFIGASTDHG----------SV-II
Gyc76C_Dmel     --------------------EMRLLR-ELRHDNINSFIGASVEP----------TRI-LL
CG4224_Dmel     --------------------ELKRMK-DLQHDHLVKFYGACLDQ----------RRS-FL
CG3216_Dmel     --------------------EIKQAR-DVSHENTVRFVGACIDLPR--------PTV-LI
KSGC_Mmus       --------------------EVCLMC-ELKHENIVPFFGVCTEP----------PNI-CI
HSER_Mmus       --------------------DLNKLL-QSDYYNLTKFYGTVKLD----------TRI-FG
CYGX_Mmus       --------------------FLRKLR-EMRHENVTAFLGLFVGP----------GVS-AM
CYGF_Mmus       --------------------VFEMMK-DLRHENVNPLLGFFYDS----------GMF-AI
CYGD_Mmus       --------------------AFSKLR-ELRHENVALYLGLFLAGTADSPATPGEGIL-AV
ANPb_Mmus       --------------------ELKHMR-DVQFNHLTRFIGACIDP----------PNI-CI
ANPa_Mmus       --------------------ELKHMR-DVQNEHLTRFVGACTDP----------PNI-CI
odr-1_Cele      --------------------YLYSLK-QLQHDNLAKFYGIQVNDDI--------MTM-TI
gcy-9_Cele      --------------------LLKELK-ICENDNLNKFYGISFNQQ---------NEF-IV
gcy-8_Cele      SQNPKEAGLPNYFKHLFYDRNHIQMK-AAVHDNINPFLGMVWNER---------EEM-LL
gcy-7_Cele      --------------------FMRSLR-NLDQDNLNRFIGLCLDG----------PQM-LS
gcy-6_Cele      --------------------QVVEMR-LIDHANLNKFIGMSLDA----------PQL-YS
gcy-5_Cele      --------------------KFVKLR-KLEHDNLNKFIGLSIDG----------PQF-VA
gcy-4_Cele      --------------------KFVKLR-KLDHENLNKFIGLSIDG----------SRF-VS
gcy-3_Cele      --------------------KFVKLR-KLDHENLNKFIGLSIDS----------SQF-IS
gcy-27_Cele     --------------------FLYNLK-QLKHDNLANFYGIQLNDDL--------NTM-TI
gcy-25_Cele     --------------------MLNQLK-YMSHTNINPFTGICFNQG---------SEL-IV
gcy-23_Cele     --------------------LLNQMK-QAVHDNLNPFLGMSFNEK---------EEM-VV
gcy-22_Cele     --------------------MFRKMR-NVDNDNLCKFIGLSLDS----------PTL-IS
gcy-21_Cele     --------------------EIAKLQ-ESVNSNVIEFVGMVVQS----------PDV-FV
gcy-20_Cele     --------------------EFRQMR-NFDNDNLNKFIGLCLDG----------PQL-LS
gcy-2_Cele      --------------------RFVKMR-KLDHENINRFIGLSIDS----------AHF-IA
gcy-19_Cele     --------------------TFVRLR-KLDHENVNKFVGMSIDG----------PEY-LA
gcy-18_Cele     --------------------LLTQMK-QAVHDNLNPFLGAAFNEK---------EEM-LV
gcy-17_Cele     --------------------SMHHMR-SLDHDNLNKFIGLCLNS----------QQL-LS
gcy-15_Cele     --------------------EIAKLQ-ESVNSNVIEFVGMVVQS----------PDV-FV
gcy-14_Cele     --------------------EFRQMR-NFDNDNLNKFIGLCLDG----------PQL-FS
gcy-13_Cele     --------------------ELRMLR-SIEHDNVNRFIGLSIDG----------PVY-MS
gcy-12_Cele     --------------------ELRAMR-QLAHPNVNNFLGIIVCQ----------YSV-TV
gcy-11_Cele     --------------------EIDLLM-NETHENLNRFFGLINES----------DLI-FT
gcy-1_Cele      --------------------RFVKMR-KLDHENINRFIGLSIDS----------AHF-IS
daf-11_Cele     --------------------LLYQMKSHLQHDNLNSFVGITIDKA---------SHM-YI
C04H5.4_Cele    --------------------LLTKMK-QAVHDNINPFIGVSFNEK---------SEL-LL
CYGF_Hsap       --------------------VFEMMK-DLRHENINPLLGFFYDS----------GMF-AI
ANPb_Hsap       --------------------ELKHMR-DVQFNHLTRFIGACIDP----------PNI-CI
ANPa_Hsap       --------------------ELKHMR-DVQNEHLTRFVGACTDP----------PNI-CI
CYGD_Hsap       --------------------AFSKLQ-ELRHENVALYLGLFLARGAEGPAALWEGNL-AV
T01A4.1_Cele    --------------------ELKKMK-DLQHDHITRFTGACIDF----------PHY-CV
Npr1_Spur       --------------------EIKHVR-DLQHDHVIKFIGACIDA----------PNI-SI
Npr2_Spur       --------------------ELNYMR-QVEHNNLVRFVGACVDA----------PNI-SI
Gcy3_Spur       --------------------ELKIIR-DLRHPHLNQFIGACVDPP----------NI-CT
Npr3_Spur       ----------------------YKMR-NLEHTNVVRFVGACVDP----------PDQ-AI
Npr4_Spur       --------------------EVKQVR-DLQHSNLCKFAGGCIEV----------PNV-SI
Gcy1_Spur       --------------------ELKIMR-DMRHDNICPFIGACIDRP----------HI-SI
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       --------------------ELKEMR-WLVHDNINRFLGLCFPSTS-------GDMF-YH
AqueK220_Aque   --------------------KILTIL-DFKHDNICPFVGGILQG----------SLITGL
AqueK221_Aque   --------------------TMLQIL-NFDHENICPFIGCILQG----------PTIVGM
AqueK222_Aque   --------------------EVMQIR-SLDHANVCRFIGATLRSS---------ENV-II


HSER_Hsap       VIEYCERGSL-REVLNDTISYPDGTF--MDWEFKISVLYDIA-------KGMSYLHS-SK
CG10738_Dmel    ISEYCTRGSL-KDILEN-----EDVK--LDNMFIASMVADII-------RGVIYLHD-SP
CG9783_Dmel     VFDYCSRGSL-QDVLIM-----DEIK--LDWSFRLSLLTDLV-------RGMRYLHT-SP
Gyc32E_Dmel     FTTYCARGSL-EDVLAN-----EDLH--LDHMFISSLVSDIL-------KGMIYLHD-SE
Gyc76C_Dmel     VTDYCAKGSL-YDIIEN-----EDIK--LDDLFIASLIHDLI-------KGMIYIHN-SQ
CG4224_Dmel     LTEYCPKGSL-QDILEN-----EQFQ--LDWMFRLSLMHDIV-------RGMQFLHS-SD
CG3216_Dmel     LTEYCSRGSL-KDVLEN-----EAIE--LDWNFRMSLIHDIV-------KGMNYLHN-SD
KSGC_Mmus       VTQYCKKGSL-QDVMRN-----SDHE--IDWIFKLSFAYDIV-------NGLLFLHG-SP
HSER_Mmus       VVEYCERGSL-REVLNDTISYPDGTF--MDWEFKISVLNDIA-------KGMSYLHS-SK
CYGX_Mmus       VLEHCARGSL-EDLLQN-----ENLR--LDWTFKASLLLDLI-------RGLRYLHH-RR
CYGF_Mmus       VSEFCSRRSL-EDILTN-----DDVK--LDWMFKSSLLLDLI-------KGMKYLHH-RE
CYGD_Mmus       VSEHCARGSL-HDLLAQ-----REIK--LDWMFKSSLLLDLI-------KGMRYLHH-RG
ANPb_Mmus       VTEYCPRGSL-QDILEN-----DSIN--LDWMFRYSLINDLV-------KGMAFLHN-SI
ANPa_Mmus       LTEYCPRGSL-QDILEN-----ESIT--LDWMFRYSLTNDIV-------KGMLFLHN-GA
odr-1_Cele      LHTLVERGTL-EEFCLD-----RDFG--MDDTFKSAFMRDIL-------KGLQYLHK-SS
gcy-9_Cele      MWVLCSRGSL-EDILFN-----DELK--LGRNFQVSFAKDVV-------KGLNFLHT-SP
gcy-8_Cele      VWKFCSRGTL-QDIIYN-----ESIQ--LDTKFHGAFIRDIL-------AGLEYLHA-SQ
gcy-7_Cele      VWRFCSRGSI-ADVILK-----ATIQ--MDNFFIYSLIKDMV-------HGLVFLHG-SM
gcy-6_Cele      VWRFCSRGSL-ADVIRK-----ASMQ--MDGFFIYSLMKDII-------NGLTWIHE-SS
gcy-5_Cele      VWKMCSRGSL-QDIIAR-----GNFS--MDGFFMFCIITDIA-------EGMNFLHK-SF
gcy-4_Cele      VWKMCSRGSL-QDIISK-----GSFS--MDYFFMFCMIRDIA-------EGLHYIHK-SF
gcy-3_Cele      VTKLCSRGSL-LDILYK-----GNFS--MDFFFMYCIIKDVA-------EGMSYLHK-SF
gcy-27_Cele     LHALVERGTL-EEFCLD-----RDFG--MDETFKSAFMRDIL-------KGLQYLHL-SP
gcy-25_Cele     MWQFTTRYSL-EDLIFV-----KEQK--FGRNFQSTFIKHIV-------HGINYIHN-SS
gcy-23_Cele     LWKFCSRGTI-QDMIYN-----QEVS--LDSKFHGAFIRDIT-------LGLEYLHS-SI
gcy-22_Cele     IWRYCSRGSL-QDVIAK-----GSLQ--MDWFFKYSLMRDVA-------DAIYYLHH-SP
gcy-21_Cele     VYELAQRGSL-KDILDN-----DDMP--LDDVFRSQMTKDII-------AGLEYLHS-SP
gcy-20_Cele     LWRFCSRGSL-SDVISK-----SSMQ--MDSFFMFSLIRDIS-------NGLYFIHS-SF
gcy-2_Cele      VTKLCSRGSL-QDILSR-----GNFS--MDYFFMFCIIRDVA-------KGLEYLHK-TF
gcy-19_Cele     VWKLCMRGSL-QDIIGQ-----GNFS--IDPFFMFCVIRDMA-------EGLKYLHN-SF
gcy-18_Cele     LWKFCSRGTI-QDIIYN-----ANVV--LDEKFHGAFVRDIT-------LGLEYLHA-SP
gcy-17_Cele     IWRYCSRGSL-ADVISR-----SSMQ--MDSFFMLSLIRDIA-------NGLGFIHT-SM
gcy-15_Cele     VYELAQRGSL-KDILDN-----DDMP--LDDVFRSQMTKDII-------AGLEYLHS-SP
gcy-14_Cele     LWRFCSRGSL-SDVISK-----SSMQ--MDSFFMFSLIRDIS-------NGLLFIHN-SF
gcy-13_Cele     FWRYCSRGSI-KDVIAK-----SSIN--MDGFFIYCLIKDIASVSRHENPGLQYIHH-SP
gcy-12_Cele     VREYCSKGSL-HDILRN-----ENLK--LDHMYVASFVDDLV-------KGMVYIHD-SE
gcy-11_Cele     IHSYGPRKSL-MDLLRN-----DDLR--LDRMFKVSFVEDVV-------KGLQFLHEGSK
gcy-1_Cele      VTKLCSRGSL-QDILSR-----GNFS--MDYFFMFCIIRDVA-------KGLEYLHK-TF
daf-11_Cele     IWNQCFRGSL-HDHIFT-----KERQRGTATRFEGLFLRDIL-------KGLEYIHA-SA
C04H5.4_Cele    LWKFCSRGTL-QDVIYC-----EKFA--MDEKFQGAFVRDIT-------MGLEYLHS-SP
CYGF_Hsap       VTEFCSRGSL-EDILTN-----QDVK--LDWMFKSSLLLDLI-------KGMKYLHH-RE
ANPb_Hsap       VTEYCPRGSL-QDILEN-----DSIN--LDWMFRYSLINDLV-------KGMAFLHN-SI
ANPa_Hsap       LTEYCPRGSL-QDILEN-----ESIT--LDWMFRYSLTNDIV-------KGMLFLHN-GA
CYGD_Hsap       VSEHCTRGSL-QDLLAQ-----REIK--LDWMFKSSLLLDLI-------KGIRYLHH-RG
T01A4.1_Cele    VTEYCPKGSL-EDILEN-----EKIE--LDKLMKYSLLHDLV-------KGLFFLHN-SE
Npr1_Spur       MTEYCPKGSL-QDILEN-----DSIE--LDELFKYSLMYDIV-------KGMLYLHN-SV
Npr2_Spur       ISEYCPKGSL-QDIVEN-----DALK--LDNMFKNSLITDVM-------RGLHYLHS-SV
Gcy3_Spur       ITEYCPKGSL-QDILEN-----DEVK--LDSMFIASLIGDIL-------KGLSCLHA-SE
Npr3_Spur       LTEYCPRGSL-QDILEN-----DQLK--LDLMFRQSLLMDAV-------RGLNYIHD-SV
Npr4_Spur       ITEYCPKGAL-SDVLLN-----EDVP--LNWSFRFSFCMDVA-------RGMHYMHN-NK
Gcy1_Spur       LMHYCAKGSL-QDILEN-----DDIK--LDSMFLSSLIADLV-------KGIVYLHS-SE
Gcy2_Spur       ----CLRKELKVDILEN-----DDIK--LDEMFIASLVSDIV-------KGMRHLHS-TE
Npr5_Spur       VSEFSPKGSL-KSILAN-----DDVN--LDLSFKASFIRDLA-------RGMQFLHA-SE
AqueK220_Aque   MYEYCTRGSL-YDLLTN-----PHIG--FNKSFRQSFAIDCS-------EGLAYLHG-RK
AqueK221_Aque   MHEYCSHGSL-YEVLRN-----PNIV--FDKQFRVLFATDII-------KGLTYLHS-HK
AqueK222_Aque   LTEYCPKGSL-NDVLQN-----DDIP--LNWGFRFSFVTDIS-------RGLAYLHS-KR
                      :  :  .                       .  .          .:  :*

HSER_Hsap       TEVHGRLKSTNCVVDSRMVVKITDFGCNSILPP---------------------------
CG10738_Dmel    IRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSS-------------TD-------
CG9783_Dmel     LRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLP-----------------------
Gyc32E_Dmel     IISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEP---------------N-------
Gyc76C_Dmel     LVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENES-------------I--------
CG4224_Dmel     IRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLE-------------SD-------
CG3216_Dmel     VAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFV-----------------------
KSGC_Mmus       LRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWR--------------SY-------
HSER_Mmus       IEVHGRLKSTNCVVDSRMVVKITDFGCNSILPP---------------------------
CYGX_Mmus       F-PHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSS-----------------------
CYGF_Mmus       F-IHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLS-----------------------
CYGD_Mmus       V-AHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVL-----------------------
ANPb_Mmus       ISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE----------------PD-------
ANPa_Mmus       IGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPE-----------------PE-------
odr-1_Cele      IGYHGHLQASTCLIDINWVLKLTLYGVSNFMSDQLDAEN---------IKVPE-------
gcy-9_Cele      LLHHGMLCLQNCLVDSNWTVKLTNFATEAVIFEKLDHNELRPFINTDSESADDVS-----
gcy-8_Cele      IGYHGSLTPWSCLIDRNWMIKLTDYGIADPLERWEKSQSI----SRDGLTSDD-------
gcy-7_Cele      VGYHGMLTSKCCLIDDRWQVKISNYGLQDLRSPE--------------------------
gcy-6_Cele      HEFHGMLTSKNCLLNDRWQLKITDFGLRIFRTHD--------------------------
gcy-5_Cele      LHLHGNLRSATCLVNDSWQVKLTDFGLGALLEEH--------------------------
gcy-4_Cele      LRHHGNLRSATCLVNDSWQVKLADFGLQFLQDEE--------------------------
gcy-3_Cele      LRLHGNLRSATCLVNDSWQVKLAEFGFDQLLEEI--------------------------
gcy-27_Cele     VAYHGHLHAATCLIDINWVLKIALYGVTNFVCDNFDAEN---------ITMPD-------
gcy-25_Cele     IKVHGALYLSNCVVDSYWVVKLTDFGIKGILKERTNHKE---------LAPSS-------
gcy-23_Cele     IGYHGSLTPWSCLIDRNWMIKLTDYGIANPLERWEKLGLI----STETLKEGD-------
gcy-22_Cele     IGPHGWLSSSTCLVDERWQVKVSFFGLSAIKQYE--------------------------
gcy-21_Cele     IGCHGRLKSTNCLIDARWMVRLSSFGLRELRGEETWQQ-------------ED-------
gcy-20_Cele     LKCHGQLTSRCCLIDDRWQIKISGFGLKSVRTFE--------------------------
gcy-2_Cele      LRLHGNLRSATCLVNDSWQVKLAEYGMDNLVEEQ--------------------------
gcy-19_Cele     LHVHANLRSGTVLVNESWQAKLTDFGLGTLAEEK--------------------------
gcy-18_Cele     IGYHGSLTPWCCLIDRNWMVKLSDYGIANPLERWEKQGAI----EIAAAKDSD-------
gcy-17_Cele     LHFHGYLSSRSCLIDDRWQVKISDFGLNEVRGMD--------------------------
gcy-15_Cele     VGCHGRLKSTNCLIDARWMVRLSSFGLRELRGEETWQQ-------------ED-------
gcy-14_Cele     LKCHGHLTSRCCLIDDRWQIKISGYGLKSVRTFE--------------------------
gcy-13_Cele     IKQHGSLTSECCYINDRWQVKIGSYGLSFMQGVE--------------------------
gcy-12_Cele     LKMHGNLKSTNCLITSRWTLQIADFGLRELREGIMYDS-------------S--------
gcy-11_Cele     IGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVEEPESK-------------PD-VFYDLV
gcy-1_Cele      LRLHGNLRSATCLVNDSWQVKLAEYGMDNLVEEQ--------------------------
daf-11_Cele     IDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQ---------IFTED-H-----
C04H5.4_Cele    IGYHGGLACWSVLIDKNWMLKLTDYAVCDPLKRWEKHGRI-------NCKVDN-------
CYGF_Hsap       F-VHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLS-----------------------
ANPb_Hsap       ISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE----------------PD-------
ANPa_Hsap       ICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLD-----------------PE-------
CYGD_Hsap       V-AHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVL-----------------------
T01A4.1_Cele    IRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEIN--------------LE-------
Npr1_Spur       IQTHGNLKSSNCVVDSRFVLKITDFGLTSFREPDHAFE-------------PD-------
Npr2_Spur       IMLHSRLSSSNCVVDSRFVLKLTDYGLTKFRDTDS----------------NE-------
Gcy3_Spur       THSHGNLKSSNLVVDSRWVLKITDFGLHQFRSGSRPP---------------E-------
Npr3_Spur       IGVHGRLTSSNCVVDGRFVLKITDFGIPSFRNSNK----------------YE-------
Npr4_Spur       L-YHGKLTSSNCVVDDRWVVKIADYGLTTFRNQEGSQS--------------N-------
Gcy1_Spur       IKSHGHLKSSNCVVDNRWVLQITDYGLNEFKKGQKQ-D-------------VD-------
Gcy2_Spur       IRTHGNLKSSNCVVDSRWVLKITDFGLVHFKVGQQPP---------------D-------
Npr5_Spur       IKNHGVLSSSTCYVDSRWVLKISGFGLLSFNILKEDVM-------------KQ-------
AqueK220_Aque   A-IHGRLTSNNCVIDQHWNLKLTDYEPIDIHYTKVKRL-------------S--------
AqueK221_Aque   L-THGRLSSVTCVIGNLWKLKLTDYGPDALHSMRTGSQ-------------G--------
AqueK222_Aque   IV-HHRLMSTNCVIDDRWVVKITDYGIPSLRVCDSDRA-------------S--------
                   *  *      :      ::  .

HSER_Hsap       --------------------KKDLWTAPEHLRQAN-------------------------
CG10738_Dmel    ----------M--QHMSAKCLKLLYRAPELLRQGPS---SL------------------V
CG9783_Dmel     ----------P----RTRSAKELLWTAPELLRNMK----LH---------QHHHQHGRIQ
Gyc32E_Dmel     ----------K----SELELKRALCMAPELLRDAY----RP------------------G
Gyc76C_Dmel     -------------GE-HQHYRNQLWRAPELLRNH-------------------------I
CG4224_Dmel     ----------GGNCNSHAYWSKLLWTAPELLRVEHN---RP------------------P
CG3216_Dmel     --------------RDQNYYLKLLWIAPELLPLTT----IP---------GC-------C
KSGC_Mmus       ----------N---QEATDHSELYWTAPELLRLRE----SP------------------C
HSER_Mmus       --------------------KKDLWTAPEHLRQAT-------------------------
CYGX_Mmus       ----------R----PQPAPEELLWTAPELLRGPG-------------------------
CYGF_Mmus       ----------E----EEPSEEELLWTAPELLRAPG----G------------------IR
CYGD_Mmus       ----------P----EPPSAEDQLWTAPELLRDPS----L------------------ER
ANPb_Mmus       ----------D----SHALYAKKLWTAPELLSGNP----LP------------------T
ANPa_Mmus       ----------Q----GHTLFAKKLWTAPELLRMAS----PP------------------A
odr-1_Cele      ----------Q--AAHMITYPQYVCFPPEHIREYDD---SGK------QPPR------VV
gcy-9_Cele      ----------D--PTKDFARKKYLQQAPEIIREIVT---T----------KT------IP
gcy-8_Cele      ----------D--KSQATQATSILYESPEMLKNREK---NRVRRVDQDWMRQ------TQ
gcy-7_Cele      ----------------MYEKKDLLWSAPELLRAED----I--------------------
gcy-6_Cele      ----------------QYNKSDRLWTSPELLRTDD----I--------------------
gcy-5_Cele      ----------------TPSKKRLLWAAPEVLRGSL----TI------------------H
gcy-4_Cele      ---------------EKPFKKNMLWAAPEVIRGSL----SI------------------E
gcy-3_Cele      ----------------TPTKRRLLWAAPEVLRGSL----TV------------------S
gcy-27_Cele     ----------R--SDYTISYAQYVCFPPEHIREYDA---TGK------LPTR------FV
gcy-25_Cele     ----------A--FDVDAIHYKYLQLAPEHISAILE---K----------LE------EP
gcy-23_Cele     ----------D--KSGSAQKTSLLYQPPEMLKNKES---NRTRRMDQSWVKQ------SQ
gcy-22_Cele     ----------------VKEQRDFLHTAPEHIRDTN----L--------------------
gcy-21_Cele     ---------------DVQEGKDQLWTSPELLRWSTG---LS---------QC------GV
gcy-20_Cele     ----------------NPKKEDLLWASPEYLRNED----Q--------------------
gcy-2_Cele      ----------------TPPKKRLLWVAPEVLRGSL----SV------------------S
gcy-19_Cele     ----------------KPMKRRQLWMAPEVIRGTL----LP------------------H
gcy-18_Cele     ----------D--KSQASQATSIIYMAPELLKNRET---NKRRGMDQSWVKQ------SM
gcy-17_Cele     ----------------KLSTENMLWWAPEVLRGLE-------------------------
gcy-15_Cele     ---------------DVQEGKDQLWTSPELLRWSTG---LS---------QC------GV
gcy-14_Cele     ----------------NPKKEDLLWTPPENLRNEN----E--------------------
gcy-13_Cele     ----------------KRTEDGLLHTAPEVLREGL----T--------------------
gcy-12_Cele     ----------------YNIWENFLWTAPEAMTINGS---L----------AI------SN
gcy-11_Cele     IFSNKYNSKTK--NPIKKFSTDLLWFAPEIIRRYAV---KH---------DL------SK
gcy-1_Cele      ----------------TPPKKRLLWVAPEVLRGSL----SV------------------S
daf-11_Cele     --------------TPVIKSEELHYFDPAMKKIWKNYADRNE------RALI------TP
C04H5.4_Cele    ----------E--AEKQWQKMASLYVPPEIRTANEK---NRLKRMDQKWQGQ------TI
CYGF_Hsap       ----------E----EESSMEELLWTAPELLRAPR----G------------------SR
ANPb_Hsap       ----------D----SHALYAKKLWTAPELLSGNP----LP------------------T
ANPa_Hsap       ----------Q----GHTVYAKKLWTAPELLRMAS----PP------------------V
CYGD_Hsap       ----------P----EPPRAEDQLWTAPELLRDPA----L------------------ER
T01A4.1_Cele    ----------E--IGEHAYYKKMLWTAPELLRDSN----AP------------------P
Npr1_Spur       ----------E--EDSYKYYQRRLWTAPELLRLPE----IP------------------S
Npr2_Spur       ----------R---QTSKNEQKMLWQAPETLRSAN----Q--------------------
Gcy3_Spur       ----------I--G-EHAKYEKLLWRAPELLRDPA----PR------------------P
Npr3_Spur       -----------------DNNYKLLWRAPERLRDPF----S--------------------
Npr4_Spur       ----------A---GGYRSKAMQVYLPPENRSNTY------------------------T
Gcy1_Spur       ----------L---GDHAKLARQLWTSPEHLRQEGS---MP------------------T
Gcy2_Spur       ----------M--G-EHAYYQDLLWKAPEVWE---------------------------P
Npr5_Spur       ----------K---DPEVKFSKMLWTAPEHLRGEM----LP------------------S
AqueK220_Aque   ---------------KLKTAAKKIY--------------Y------------------LP
AqueK221_Aque   ---------------K-KSSTQ--Y--------------S------------------YC
AqueK222_Aque   -------------EEGERRKRCLVFFPPEERDST-Y-----------------------Y


HSER_Hsap       -ISQKGDVYSYGIIAQEIILRKE--TFYTLS--C--------------RD--RNE-----
CG10738_Dmel    MGTQRGDAYSFGILLYEMHVRRG--PFGETG-----------------LT--PMQ-----
CG9783_Dmel     LGTQLGDVYSFGIIMQEVVVRGE--PYCMLS-----------------LS--PEE-----
Gyc32E_Dmel     RGSQKGDVYSFGILLYEMIGRKG--PWGDTA-----------------YS--KEE-----
Gyc76C_Dmel     HGSQKGDVYAFAIIMYEIFSRKG--PFGQIN-----------------FE--PKE-----
CG4224_Dmel     EGTQKGDVYAFGIIVHEITTRQG--PFYLGRCAYE-------------KS--PQE-----
CG3216_Dmel     PATQRGDVYSFGIILEEIVNRGG--PYQEAR--QQ-------------MD--VHT-----
KSGC_Mmus       SGTPQGDVYSFAILLRDLIHQQAHGPFEDLE-----------------AA--PEE-----
HSER_Mmus       -ISQKGDVYSFAIIAQEIILRKE--TFYTLS--C--------------RD--HNE-----
CYGX_Mmus       KATFKGDVFSLAIILQEVLTRDP--PYCSWG-----------------LS--AEE-----
CYGF_Mmus       LGSFAGDVYSFAIIMQEVMVRGA--PFCMMD-----------------LP--AKE-----
CYGD_Mmus       RGTLAGDVFSLAIIMQEVVCRST--PYAMLE-----------------LT--PEE-----
ANPb_Mmus       TGMQKADVYSFAIILQEIALRSG--PFYLEG--LD-------------LS--PKE-----
ANPa_Mmus       RGSQAGDVYSFGIILQEIALRSG--VFYVEG--LD-------------LS--PKE-----
odr-1_Cele      RGSPKGDIYCVGMIFYMMVERED--PYHLIH--S---------------V--ERP----N
gcy-9_Cele      EGSQSADIYALGMVLYQILFRVE--PFHERN--K---------------S--INK----L
gcy-8_Cele      TRRQLGDVYAFGLVMYEIIFRAL--PFPEG---T---------------N--QSE-----
gcy-7_Cele      KGSKEGDVYSLGIICAELITRKG--VFNMED--RK-------------ED--PEE-----
gcy-6_Cele      LGSREGDIYSFGIISAELITRSS--VFDLEN--RK-------------ED--AEE-----
gcy-5_Cele      QMDPSADVYSFAIIASEILTKRE--AWDISN--RK-------------EG--ADE-----
gcy-4_Cele      QMDSSADIYSFAIVASEILTKRE--AWDLSR--R------------------KEE-----
gcy-3_Cele      QMDPSADVFSFAIIASEILTRKE--AWDLKE--RK-------------EG--YDE-----
gcy-27_Cele     RGSKQGDIYCVGMIFYMMIERED--PYRLIH--S---------------V--ERP----G
gcy-25_Cele     RGTVEGDIYQLAMCIYQILFYMR--PFAERQ--ES-------------IKVYSGEIFLKL
gcy-23_Cele     ARRQMGDIYAFGMVMHEILFRAL--PFPNG---T---------------N--VSE-----
gcy-22_Cele     PITKEMDIYSFAIICSELITKKS--AWDLEN--ET-------------FD--IEE-----
gcy-21_Cele     LLVQKSDVYSLAIVLYELFGRLG--PWGDEP--M---------------E--PRE-----
gcy-20_Cele     ERLPEGDIYSFGIICAEILTRSS--AFDLEN--RK-------------EK--PDV-----
gcy-2_Cele      QMEPSADIYSFAIIASEILTKKE--AWDILD--RK-------------E-----------
gcy-19_Cele     QIEKSADIYSLAVIASEVLTRKE--AWNMAE--RK-------------DT--VDE-----
gcy-18_Cele     LRRQAGDIYSFGMVMYEILFRSL--PFRDN---T---------------N--ISE-----
gcy-17_Cele     QRSKEADIYSFGIICSEVITRSS--AFDLEN--RK-------------EK--PEE-----
gcy-15_Cele     LLVQKSDVYSLAIVLYELFGRLG--PWGDEP--M---------------E--PRE-----
gcy-14_Cele     ERLPEGDIYSFGIICSEILTRSS--AFDLEN--RK-------------EK--PDV-----
gcy-13_Cele     SGTQAGDVYSFSIVCSELVGHSS--AWNLEN--RK-------------EE--ADE-----
gcy-12_Cele     PPTPKADAYSFGIIFHEIFTREG--PYKIYV--QRGDVNGEAAPKKDSVE--CRA-----
gcy-11_Cele     LELAKADIYSLAIVLYEIYGRQG--PFGDDL--L---------------D--SDE-----
gcy-1_Cele      QMEPSADIYSFAIIASEILTKKE--AWDILD--RK-------------ED--CEE-----
daf-11_Cele     QFGKKCDMYSFGVILHEIILKKK--FVEQLF--D---------------S--PRE---ED
C04H5.4_Cele    LKRQQSDIYAFGVIIYEILFRSL--PYDEK---V---------------D--LTE-----
CYGF_Hsap       LGSFAGDVYSFAIIMQEVMVRGT--PFCMMD-----------------LP--AQE-----
ANPb_Hsap       TGMQKADVYSFGIILQEIALRSG--PFYLEG--LD-------------LS--PKE-----
ANPa_Hsap       RGSQAGDVYSFGIILQEIALRSG--VFHVEG--LD-------------LS--PKE-----
CYGD_Hsap       RGTLAGDVFSLAIIMQEVVCRSA--PYAMLE-----------------LT--PEE-----
T01A4.1_Cele    MGTQKGDIYSFAIILHEMMFRKG--VFALEN--ED-------------LS--PNE-----
Npr1_Spur       GGTQKGDVYSFGIILQEIMYREG--VFYIKD--VD-------------LM--PEE-----
Npr2_Spur       QPTQKGDIYSVGIIMQEIVTRAR--PFEEER--SS-------------ME--IDE-----
Gcy3_Spur       EGTQKGDMYSLGIILYEMATRQG--PYGKCV-----------------LG--PKE-----
Npr3_Spur       PPSKEGDLYALGIIMLEIGTRCG--PFDEER--KV-------------MD--TNG-----
Npr4_Spur       LVTQATDVYSYGVILVEIASRNE--VIPEDD--YP-----------------LD------
Gcy1_Spur       AGSPQGDIYSFAIILTELYSRQE--PFHENE-----------------MD--LAD-----
Gcy2_Spur       QGTQKGDVYSFGIILYEIAHRQG--PFGNCE-----------------LS--PKE-----
Npr5_Spur       KGSQKGDVYSFAIILQEIVTRSH--PFYLSG-----------------YT--SRE-----
AqueK220_Aque   DQDTVSDIYNFGVILTELCCRET--LLKFGS--I---------------N--FGK-----
AqueK221_Aque   SQDVSDDIYNFGLVLKEMSSRQY--IIKDKV--A---------------T--IDE-----
AqueK222_Aque   IPTLSGNVYSFSIILLETATRID--PYSEEL-----------------F-----------
                      : :  .:

HSER_Hsap       ---KIFRV-ENS---NGMKPF--RPDLFLET----A---------EEKELEVYLLVKNCW
CG10738_Dmel    ---CLQKV-LQPQ--DYLNPY--RPSLQPLE---------T------AFDCVSECLRECW
CG9783_Dmel     ---IIVKI-KKP-----PPLI--RPSVSKG----------------AAPPEAINIMRQCW
Gyc32E_Dmel     ---IIQFV-KCPE-MLQHGVF--RPALTHTH----L----D------IPDYIRKCLCQCW
Gyc76C_Dmel     ---IVDYV-KKLP-LKGEDPF--RPEVESII----E----A----ESCPDYVLACIRDCW
CG4224_Dmel     ---IIELV-KGYNPHRMQKPF--RPELEPN---------------GDTKADINGIIRRCW
CG3216_Dmel     ---ILHKV-RQ------CNGF--RPLIRER----------------ECPPDLLELMEKCW
KSGC_Mmus       ---IISRI-KDP---RAPVPL--RPSLLED----------------KGDGRIVALVRECW
HSER_Mmus       ---KIFRV-EN----SYGKPF--RPDLFLET----A---------DEKELEVYLLVKSCW
CYGX_Mmus       ---IIRKV-ASP-----PPLC--RPLVSPD----------------QGPLECIQLMQLCW
CYGF_Mmus       ---IIDRL-KMP-----PPVY--RPVVSPE----------------YAPAECLQLMKQCW
CYGD_Mmus       ---VIQRV-RSP-----PPLC--RPLVSMD----------------QAPMECIQLMTQCW
ANPb_Mmus       ---IVQKV-RNG----QRPYF--RPSIDRT----------------QLNEELVLLMERCW
ANPa_Mmus       ---IIERV-TRG----EQPPF--RPSMDLQ----------------SHLEELGQLMQRCW
odr-1_Cele      AT-LIKQI-LNE-------NH--MPRITDD---------------YRQENMLLEMCKECW
gcy-9_Cele      ME-TLAMA-NDD-----DQLI--RPTFPSSN----T----G----EGYNLQLLSCIEACW
gcy-8_Cele      ---LVEWL-RDG-----SKVV--KPTIPQN---------------KVLNMDLSALIQDCW
gcy-7_Cele      ---IIYLL-KKG----GLKSP--RPDLEYDH----T---------IEINPALLHLVRDCF
gcy-6_Cele      ---IIYML-KKG----GLQSP--RPSLEHDE----S---------IEINPALLHLVRDCW
gcy-5_Cele      ---ILYMV-KKG----GNRTI--RPELILD---------------AEVSPRLTTLVKDCW
gcy-4_Cele      ---IKYAV-KKG----GQFVL--RPDLHID---------------IEVNQTLLALVKDCW
gcy-3_Cele      ---IIYRV-KKG----GSFPI--RPDIITDV--------------PDVNPTLIALVKDCW
gcy-27_Cele     SG-LMMEI-LDH-------NL--MPFISNN---------------ETQEDTLLDKCKECW
gcy-25_Cele     PE-LAHLL-SSQ----STAPL--HPKVPEG---------------NSFTMRLLSIIQQCW
gcy-23_Cele     ---VMDYI-RDG-----TKTF--RPTVHDR---------------TQIHPDLVALLLDCW
gcy-22_Cele     ---LVYKI-KKG----GRSPP--RPSLETED---------------EHNGSMSLLVRDCW
gcy-21_Cele     ---IVSLV-KREA-LAGKKPF--RPDMAVLK---------------ESPRIVQETVVAAW
gcy-20_Cele     ---IIYQV-KKG----GHNPT--RPSLDTGE----T---------VVINPALLHLVRDCW
gcy-2_Cele      -----------------------------------------------DCEALIALVKDCW
gcy-19_Cele     ---IVYRI-KKG----GPNAP--RPELDMDG--------------VEINHNLLILIRDCW
gcy-18_Cele     ---LVDYL-ADG-----SKTV--SPEIQNQ---------------MGLHPDLNALLRDCW
gcy-17_Cele     ---IIYQL-KKG----GFNAI--RPSLLTDE----A---------LEINPALVHLIRDCW
gcy-15_Cele     ---IVSLV-KREA-LAGKKPF--RPDMAVLK---------------ESPRIVQETVVAAW
gcy-14_Cele     ---IIYQV-KKG----GHNPM--RPSLDTGE----T---------VEINPALLHLIRDCW
gcy-13_Cele     ---IIFMV-KRG----GRTPF--RPSLDDVD--------------DDINPAMLHLIRDCW
gcy-12_Cele     ---LVEKTVRRV---YSDPYF--RPDTSD-L---------------EVQNYVKEVMAACW
gcy-11_Cele     ---IIEQL-KFP---DGGALT--RPDIHLIT---------------KAPYPLASVVEKCW
gcy-1_Cele      ---IVYNV-KKG----GLFPI--RPEIITDI--------------HDVNPALIALVKDCW
daf-11_Cele     DSVLIDDE-NDA-----IASRFPLPIIIP------E----G----IEMHNDLIKMLENCF
C04H5.4_Cele    ---LAQKA-AEG-----DKIQ--KPSIQRN---------------KKLNPDLIALLQDCW
CYGF_Hsap       ---IINRL-KKP-----PPVY--RPVVPPE----------------HAPPECLQLMKQCW
ANPb_Hsap       ---IVQKV-RNG----QRPYF--RPSIDRT----------------QLNEELVLLMERCW
ANPa_Hsap       ---IIERV-TRG----EQPPF--RPSLALQ----------------SHLEELGLLMQRCW
CYGD_Hsap       ---VVQRV-RSP-----PPLC--RPLVSMD----------------QAPVECILLMKQCW
T01A4.1_Cele    ---IVQRV-RKPV-SEDQEPL--RPWVSETGEGEGD---------DALNDTLLSLMVACW
Npr1_Spur       ---IVKKV-ANG----YKPAF--RPTIDRV----------------TCSQEMMTLITNCW
Npr2_Spur       ---IVKKL-TE----TSSPPF--RPEIDPQ----------------LCTDEIRSIIQACW
Gcy3_Spur       ---IVDKV-THPL--DPNTPF--RPNVMEVD---------D------CPNCMLTGMQECW
Npr3_Spur       ---ILEIL-KST---SSQPPF--RPSVPEA----------------VWNPVIKDLMKRCW
Npr4_Spur       -E-------------A-WRPP--LPDLEIGD----TTDDER----CPCPADYLSLIERCW
Gcy1_Spur       ---IIARV-KIG----EVPPY--RPILNAVN----A----A------APDCVLSAIRACW
Gcy2_Spur       ---IYEKV-KTL---GETIPL--RPNVMEIE---------N------GHECLLTVMQECW
Npr5_Spur       ---IIRRV-IRR----DEPPC--RPKINEDE----F----ETSDMATIFTAIYELMKVCW
AqueK220_Aque   ---I-----------------------HYD---------------EDVGDRYVELIEKCH
AqueK221_Aque   ---L-----------------------EYD---------------IEVPFEIKKLIESCI
AqueK222_Aque   -----I----DT---TTGRPR--LPDLAQ------E----G----CPCPSTYQELIESCW
                                                                          .

HSER_Hsap       EEDPEKRPDFKKIETTLAKIFGLFHDQK--NESYMDTLIRRLQLYSRNLEHLVEERTQLY
CG10738_Dmel    AERPEDRPDFKTIRTKLRPL----RKGMR--PNIFDNMMAMMEKYANNLEALVDDRTDQL
CG9783_Dmel     AEQPDMRPDFNSVYERFKML----NHGR--KVNFVDTMFQMLEKYSNNLEELIRERTEQL
Gyc32E_Dmel     DEDPEVRPDIRLVRMHLKEL----QAGLK--PNIFDNMLSIMEKYAYNLEGLVQERTNLL
Gyc76C_Dmel     AEDPEERPEFSVIRNRLKKM----RGGKT--KNIMDQMMEMMEKYANNLEDIVTERTRLL
CG4224_Dmel     AEDPAERPDFNTLKSMIRRF----NKDNE-TGNIVDNLLKRMELYANNLEELVEERTQDY
CG3216_Dmel     ADNQEERPTFSTIRSNIRTI----MKG-F-CENLMDDLLNRMEQYANNLESLVEEKTRQL
KSGC_Mmus       DESPELRPIFPSIKKTLREA----SPRG--HVSILDSMMGKLETYANHLEEVVEERTREL
HSER_Mmus       EEDPEKRPDFKKIESTLAKIFGLFHDQK--NESYMDTLIRRLQLYSRNLEHLVEERTQLY
CYGX_Mmus       EEAPDDRPSLDQIYTQFKSI----NQGK--KTSVVDSMLRMLEKYSESLEDLVQERTEEL
CYGF_Mmus       AEASEQRPTFDEIFNQFKTF----NKGK--KTNIIDSMLRMLEQYSSNLEDLIRERTEEL
CYGD_Mmus       AEHPELRPSMDLTFDLFKSI----NKGR--KTNIIDSMLRMLEQYSSNLEDLIRERTEEL
ANPb_Mmus       AQDPTERPDFGQIKGFIRRF----NKEG--GTSILDNLLLRMEQYANNLEKLVEERTQAY
ANPa_Mmus       AEDPQERPPFQQIRLALRKF----NKEN--SSNILDNLLSRMEQYANNLEELVEERTQAY
odr-1_Cele      DRNPDKRPTIKKLIESIST----VYPLS--KGNLVDQMIRMSEKYADELEQMVAIRTADL
gcy-9_Cele      LEIPEMRPPIKKVRTMVNAN---LKSTG--KGSLVDQMMKMMEEYTANLENMVRDRTALL
gcy-8_Cele      NTTPEMRPSLRRIKLNVET----YL-NI--KGSLVDQMTRMMEQYANNLEKLVAERTGML
gcy-7_Cele      TERPSERPSIETVRSQLRGM----NSSR--NDNLMDHVFNMLESYASSLEEEVSERTKEL
gcy-6_Cele      TERPSERPDIKQVASQLRSM----NTNR--NDNLMDHVFNVLESYASTLEDEVAERMKEL
gcy-5_Cele      SEQPEDRPKAEQICKLLSEM----TPRG--NTNLMDHVFNMLEEYTSTLEVDIEERTKEL
gcy-4_Cele      CENPEERPSAENVCKVLFDM----TPNT--EDNLMDHVFSMLEEYTSSLEVEVGERTKEL
gcy-3_Cele      AEAPEDRPTAENICEQLRDL----MPKT--KSNLMDHVFNMLEEYTSTLEVEVEERTKEL
gcy-27_Cele     NRDPEKRPTIENLRNAIAI----CYADS--KGNLIDQMIRMNEKYADELETLVAARSADL
gcy-25_Cele     LYKPAARPALIKITDAVNR---EFGQDV--KGTLIDQMIEMIDEYSANLEQIVAERTREL
gcy-23_Cele     NENPEVRPSIRRVRLNTEN----YL-KV--KGSLVDQMMRMMEQYANNLEKLVAERTGML
gcy-22_Cele     NENPDQRPTSEQIKTLMKSM----NHNR--SSNLMDHVFNVLEQYASNLEDEVQARMKEL
gcy-21_Cele     TEDPLNRPSLHQIKRKLKPLT----IGL--KRTIMDNMVSMIEKYTDKLEKDIAERNEEL
gcy-20_Cele     TERPSERPSIEQVRSHLNGM----KDGR--KTNLMDHVFNMLETYASTLEEEVSDRTKEL
gcy-2_Cele      AEVPEDRPTAENICSQMKGL----VSKQ--KTNLMDHVFNMLEEYTSTLEEEIEERTKEL
gcy-19_Cele     SEEPADRPSADVICNLLKNM----MP-K--KGNLMDHVFNILEDYTTNLEVEVEDRTKEL
gcy-18_Cele     SENPEIRPSIRRVRLNTEM----VL-KT--KGSLVDQMMKMMEQYANNLEKLVAERTGML
gcy-17_Cele     TEKPSERPPIDQVRSLLRGM----NDGK--KGNLMDHVFNMLETYASTLEEEVNERTKEL
gcy-15_Cele     TEDPLNRPSLHQIKRKLKPLT----IGL--KRTIMDNMVSMIEKYTDKLEKDIAERNEEL
gcy-14_Cele     TERPSERPSIEQVRGHLNGM----RDGR--KSNLMDHVFNMLETYASTLEEEVSDRTKEL
gcy-13_Cele     DEDPKQRPNIDMVNKLMKNM----NSGRSGSANLMDHVFSVLEKHASSLEDEVQERMKEL
gcy-12_Cele     HHDPYQRPEFKTIKNKLKPLF---HQIY--KQNIMDHMVLMMEKYQTQLEDLVDERTIEL
gcy-11_Cele     VEDPASRPSIQKVRELLEPLS----KGL--KGNIADNIMNLLDRYRNNLEDVIKERTEQL
gcy-1_Cele      AEVPEDRPTAENICSQMKGL----VSKQ--KTNLMDHVFNMLEEYTSTLEEEIEERTKEL
daf-11_Cele     GS---VRPDIALARKIIDT----VLK-M--SGSLVDLMIKNLTAYTQGLNETVKNRTAEL
C04H5.4_Cele    SDQPDMRPTIRRVRLATEI----AL-KT--KGNLVDSMMRMMEEYANNLEKLVGERTKLA
CYGF_Hsap       AEAAEQRPTFDEIFNQFKTF----NKGK--KTNIIDSMLRMLEQYSSNLEDLIRERTEEL
ANPb_Hsap       AQDPAERPDFGQIKGFIRRF----NKEG--GTSILDNLLLRMEQYANNLEKLVEERTQAY
ANPa_Hsap       AEDPQERPPFQQIRLTLRKF----NREN--SSNILDNLLSRMEQYANNLEELVEERTQAY
CYGD_Hsap       AEQPELRPSMDHTFDLFKNI----NKGR--KTNIIDSMLRMLEQYSSNLEDLIRERTEEL
T01A4.1_Cele    SEDPHERPEVSSVRKAVRSL----NRDNE-TSNLVDNLLKRMEQYANNLEGLVEERTQEY
Npr1_Spur       KEDSTIRPDYSQLRGTMRKL----NKNSE-NKGLVDTLLSRMEQYASNLESLVQERTEAF
Npr2_Spur       EEMPENRPATTDLLSSMKKI----NKNLS-GGNILDNLLSRMEQYATNLETLVEERTAAF
Gcy3_Spur       NENPDERPEVKTLTTRLKPL----QKGMK--PNILDNMIVIMEKYANNLEDIVEDRTHQL
Npr3_Spur       AENPGDRPTASALQTALKKI----NKGTSSGGNILDNLLNRMEQYATNLESLVEERTAAF
Npr4_Spur       NINPAQRPHFSQIRQTLHSI----NPS-K--LSPVDLMMQLMEKYSRHLESIVAERTQDL
Gcy1_Spur       PEDPDDRPNIMAVRTMLAPL----QKGLK--PNILDNMIAIMERYTNNLEELVDERTQEL
Gcy2_Spur       VEDPEARPDFKTIANKLKPL----HKGMK--SDILDNMVMIMEKYANNLEEIVEDRTQQL
Npr5_Spur       EELPEDRPDFTAIRAKLRGL----QKGRK-ELDILDNMLSKMEKYTENLEKVVADRTGQL
AqueK220_Aque   QMKKSARPSASFIKGYLKDC----LSF-Y--TFHFKNDTAAAEMYSKNLERHILELNTSI
AqueK221_Aque   SNNLLQRPTTERIKTCLKRS----VA--K--CGLSQDVTGVAEVNLRNLENNIEVLKMNV
AqueK222_Aque   DEVPGNRPSFDQIKKSILRM----NPN-K--ESPVDTMMKMMEKYSKHLEALVGERTQEL
                      **                           .            *:  :

HSER_Hsap       KAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEV-
CG10738_Dmel    QEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQV-
CG9783_Dmel     DIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQV-
Gyc32E_Dmel     YEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEV-
Gyc76C_Dmel     CEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQV-
CG4224_Dmel     HEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQV-
CG3216_Dmel     SLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDV-
KSGC_Mmus       VAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQV-
HSER_Mmus       KAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEV-
CYGX_Mmus       ELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEV-
CYGF_Mmus       EIEKQKTEKLLTQMLPLSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEV-
CYGD_Mmus       EQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEV-
ANPb_Mmus       LEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQV-
ANPa_Mmus       LEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQV-
odr-1_Cele      ADAQMQTMRLLNEMLPASIAKDLKNGLIMPPRSYESATVMFVQICDFNALMKRSSPEQV-
gcy-9_Cele      EEAQKQADRLLNSMLPKSIAEDLKIGKPVLPQLYSCATVLFSDIRGFTRISSTSTPLQVC
gcy-8_Cele      EEANQRADRLLSQLLPAYVANELKLGRPVPPKTFTSSTVLFSDIVGFTEMCQNASPLEV-
gcy-7_Cele      VEEKKKSDVLLYRMLPKTVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLASKCTPLQV-
gcy-6_Cele      VEEKKKSDVLLYRMLPRQVADKLKLGQTVEPETFDIVTLFFSDVVSFTTLAGKCTPLQV-
gcy-5_Cele      TLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDTVTVLFSDVVKFTQLAAKCSPFQV-
gcy-4_Cele      TLEKKKSDILLGRMLPKQVAERLKAGQAVEPESFDLVTVFFSDLVKFTDLASKCSPFQV-
gcy-3_Cele      TLEKKKADLLLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCTPFQV-
gcy-27_Cele     ALAQMQTMRLLNEMLPASIAKDLKNGVIAPARSYASATVMFVQICDFIVILKRRPPKEV-
gcy-25_Cele     EQDMSVTENLLYQLLPKSVADSIRSGKTVVPEQHSSVTLLVVDVCQFTKFCEAFIPVHI-
gcy-23_Cele     EEANVRADKLLGQLLPKYVANELKMGRSVPAKTFDMATVMFSDIVGFTTICSSSTPLEV-
gcy-22_Cele     TEEKKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFSDVVSFTTLASRCTPLQV-
gcy-21_Cele     EGEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDI-
gcy-20_Cele     TEEKKKSDVLLYRMLPRMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQV-
gcy-2_Cele      TLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCSPFQT-
gcy-19_Cele     TAEKKKADVLLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVKFTQLAAKCSPFQV-
gcy-18_Cele     EEANIRADQLLTQLLPAYVANELKMGRSVAPKLYSSATILFSDIVGFTTICSGSTPLEV-
gcy-17_Cele     VEEQKKSDVLLYRMLPKTVAEKLKAGISIEPETFELVTIFFSDVVQFTTLASKCTPLQV-
gcy-15_Cele     EAEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDI-
gcy-14_Cele     VEEKKKSDVLLYRMLPKMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQV-
gcy-13_Cele     VEEKKKSDILLYRMLPQQVAERLKLGQSVEPEAFESVTIFFSDVVGFT----------V-
gcy-12_Cele     KDEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFPPVTIYFSDIVGFTTISGESTPMEV-
gcy-11_Cele     EDERKRNESLLLQLLPKSVANSLKNGQPVDAEFYDSVSIYFSDIVGFTALSSKSTPLQV-
gcy-1_Cele      TLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCSPFQT-
daf-11_Cele     EKEQEKGDQLLMELLPKSVANDLKNGIAVDPKVYENATILYSDIVGFTSLCSQSQPMEV-
C04H5.4_Cele    EEANLRAERLLFQLLPKHVAIELKAGRTVAPKMYDSATVMFSDIVGFTKLCSASTPIEV-
CYGF_Hsap       EIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEV-
ANPb_Hsap       LEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQV-
ANPa_Hsap       LEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQV-
CYGD_Hsap       ELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEV-
T01A4.1_Cele    LAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQV-
Npr1_Spur       YEEKRKAEELLYQILPRPVAEELKKGKPVTAESFECVTIYFSDIVGFTKLSSASTPLEV-
Npr2_Spur       LEEKKRSETLLYEVLPRSVAEQLKQGSSVSPKSYESVTIYFSDIVGFTSISADSTPLQV-
Gcy3_Spur       IEEKKKTDNLLHQMLPKPVANQLKRGMQVVPESFECVTIFFSDIVGFTSLSSESTPFEV-
Npr3_Spur       LEEKKRSETLLYEVLPRSVAEQLKQGKSVDPESYENVTIFFSDIVGFTSLSSQSTPLEV-
Npr4_Spur       LLEKQKTDRLLYSMLPQPVADDLRQGNIAKAEQYESCSIFFSDIVGFTSLSSTSSPYEV-
Gcy1_Spur       QKEKTKTEQLLHRMLPPSIASQLIKGIAVLPETFEMVSIFFSDIVGFTALSAASTPIQV-
Gcy2_Spur       VEEKKKTENLLHRMLPKPVANQLKRGMQVVPESFDCVTIFFSDIVGFTKLSSMSTPFQV-
Npr5_Spur       LEEKKKTDALLFRMLPEVVAEELKKGNQFPGEFFDHVTVYFSDVVGFTDISAQSTPMQV-
AqueK220_Aque   QDEKNANGDILANHIPKPAINAIQNKIPLKMKLAPNTVILCFGLCDIDGILSTYTKEQV-
AqueK221_Aque   SIQKQDNDLILEKCMPSEVVKSIRDKSIKPLENYDDVIIVC---VTLVDIDKDYSVSEI-
AqueK222_Aque   IIEQKKTQQLLYTMLPQAVADELRQGRPASAKQYSSVTIYFSDIVGFTTLAGASSPMEV-
                         :    :*      :               :       :

HSER_Hsap       --------VDMLNDIYKSFDHIVDHHDVYKV------ETIGDAYMVASGLPKRN-GN-RH
CG10738_Dmel    --------VDFLNDLYTCFDSIIGHYDVYKV------ETIGDAYMVVSGLPLRN-GD-LH
CG9783_Dmel     --------VDLLNDLYTIFDATINAYNVYKV------ETIGDAYMVVSGLPVKI--P-DH
Gyc32E_Dmel     --------VEMLNDWYTCCDSIISNYDVYKV------ETIGDAYMVVSGLPLQN-GS-RH
Gyc76C_Dmel     --------VNFLNDLYTVFDRIIRGYDVYKV------ETIGDAYMVVSGLPIKN-GD-RH
CG4224_Dmel     --------VQFLNDLYTCFDSIVENFDVYKV------ETIGDAYMVVSGLPIRN-GN-QH
CG3216_Dmel     --------VNFLNDLYSTFDRIIGFYDVYKV------ETIGDAYLVVSGLPEPN-GD-KH
KSGC_Mmus       --------VKLLNDLYSLFDHTIQSHDVYKV------ETIGDAYMVASGLPIRN-GA-QH
HSER_Mmus       --------VDMLNDIYKSFDQIVDHHDVYKV------ETIGDAYVVASGLPMRN-GN-RH
CYGX_Mmus       --------VGFLNDLYTLFDAVLDSHDVYKV------ETIGDAYMVASGLPRRN-GN-RH
CYGF_Mmus       --------VDLLNDLYTLFDAIIGSHDVYKV------ETIGDAYMVASGLPKRN-GS-RH
CYGD_Mmus       --------VDLLNDLYTLFDAIIGAHDVYKV------ETIGDAYMVASGLPQRN-GQ-RH
ANPb_Mmus       --------VTLLNDLYTCFDAIIDNFDVYKV------ETIGDAYMVVSGLPGRN-GQ-RH
ANPa_Mmus       --------VTLLNDLYTCFDAVIDNFDVYKV------ETIGDAYMVVSGLPVRN-GQ-LH
odr-1_Cele      --------IAFLNDIYDQFDTVIKRHDAYKV------ETTGETYMVASGVPHEN-EG-RH
gcy-9_Cele      KLRQKIIVVTFLNDMFSGFDAIIAKHDAYKV------ETIGDAYMIVSGVPTEN-GN-SH
gcy-8_Cele      --------VAVLNGIFDGFDQFIARKDAYKV------ETIGDAYMVVSGVPEEN-GH-RH
gcy-7_Cele      --------VNLLNDLYTIFDGIIEKHDVYKV------ETIGDGYLCVSGLPHRN-GN-EH
gcy-6_Cele      --------VNLLNGLYTIFDGIIEQHDVYKV------ETIGDGYFVASGVPRRN-GN-EH
gcy-5_Cele      --------VNLLNDLYSNFDTIIEEHGVYKV------ESIGDGYLCVSGLPTKN-GY-AH
gcy-4_Cele      --------VNLLNDVFSNFDSIIEKHDVYKV------ESIGDGFLCVSGLPNRN-GM-EH
gcy-3_Cele      --------VNLLNDLYSNFDTIIEEHGVYKV------ESIGDGYLCVSGLPTRN-GF-NH
gcy-27_Cele     --------IGFLNDIFDQFDTVIKRHD---V------ETTGETYMVASGVPNEN-EG-RH
gcy-25_Cele     --------LETLQELYSSFDNIVQKNKAFKV------ENVGDAYLICSGIPEMS-GF-RH
gcy-23_Cele     --------VSMLNSIYSKFDDAINKHGSYKV------ETIGDAYMIVSGIPEEN-GN-EH
gcy-22_Cele     --------VNLLNDLYTTFDAIIEQHDVYKV------ETIGDGYLCVSGLPHRN-GN-EH
gcy-21_Cele     --------VQFLNDLYTVFDRIIDQFDVYKV------ETIADAYMVASGLPVPN-GN-HH
gcy-20_Cele     --------VTLLNDLYTIFDGIIEQNDVYKV------ETIGDGYLCVSGLPHRN-GN-DH
gcy-2_Cele      --------VNLLNDLYSNFDTIIEQHGVYKV------ESIGDGYLCVSGLPTRN-GY-AH
gcy-19_Cele     --------VNLLNDLYSNFDAIIEEHGCYKV------ESIGDGYLCVSGLPSKN-GN-AH
gcy-18_Cele     --------VNMLNGLYTGFDECITRNKSYKV------ETIGDAYMVVSGIPEEN-EY-NH
gcy-17_Cele     --------VQLLNDLYTIFDSIIEQNDVYKV------ETIGDGYLCVSGLPHRN-GH-DH
gcy-15_Cele     --------VQFLNDLYTVFDRIIDQFDVYKV------ETIADAYMVASGLPVPN-GN-HH
gcy-14_Cele     --------VTLLNDLYTIFDGIIEQNDVYKV------ETIGDGYLCVSGLPHRN-GN-EH
gcy-13_Cele     --------VNLLNDLYTTFDAIIEKNDSYKV------ETIGDAYLVVSGLPRRN-GT-EH
gcy-12_Cele     --------VTFLNKLYTLFDSIIRRYDVYKV------ETIGDAYMVVSGVPQYKTME-YH
gcy-11_Cele     --------VNMLNNLYTNFDTIIDKFDCYKV------ETIGDAYMFVSGLPEVN-SY-LH
gcy-1_Cele      --------VNLLNDLYSNFDTIIEQHGVYKV------ESIGDGYLCVSGLPTRN-GY-AH
daf-11_Cele     --------VTLLSGMYQRFDLIISQQGGYKVILNRIMETIGDAYCVAAGLPVVM-EK-DH
C04H5.4_Cele    --------VNLLNKLYSEFDTVISKHDCYKV------ETIGDAYMVVSGIPIEN-GQ-RH
CYGF_Hsap       --------VDLLNDLYTLFDAIIGSHDVYKV------ETIGDAYMVASGLPKRN-GS-RH
ANPb_Hsap       --------VTLLNDLYTCFDAIIDNFDVYKV------ETIGDAYMVVSGLPGRN-GQ-RH
ANPa_Hsap       --------VTLLNDLYTCFDAVIDNFDVYKV------ETIGDAYMVVSGLPVRN-GR-LH
CYGD_Hsap       --------VDLLNDLYTLFDAIIGSHDVYKV------ETIGDAYMVASGLPQRN-GQ-RH
T01A4.1_Cele    --------VTLLNDLYLAFDGVVDNFKVYKV------ETIGDAYMVVSGLPERR--D-DH
Npr1_Spur       --------VDLLNDLYTCFDAVIDNFNVYKV------ETIGDAYMCVSGLPIRN-GD-FH
Npr2_Spur       --------VTLLNDLYTCFDGTIGNFDVYKV------ETIGDAYMVVSGLPIRN-GI-HH
Gcy3_Spur       --------VDMLNDLYTLFDEIISYYDVYKV------ETIGDAYMLVSGLPLRN-EK-KH
Npr3_Spur       --------VALLNDLYTCFDSIIANFDVYKV------ETIGDAYMVVSGLPIRN-GF-AH
Npr4_Spur       --------VALLNKLYVTFDSIIDNYDVYKV-----------------------------
Gcy1_Spur       --------VNLLNDLYTLFDAIISNYDVYKV------ETIGDAYMLVSGLPLRN-GD-RH
Gcy2_Spur       --------VDLLNDLYTLFDDIISYYNVYKV------ETIGDAYMLVSGLPIRN-DN-RH
Npr5_Spur       --------VDLLNDLYTCFDAVLERFDVYKV------ETIGDAYMVVSGLPRRN-GN-RH
AqueK220_Aque   --------SKIIVIVDRLLDGIATSFNMHRI------QSFGSTWTYISYQYEEETADKPG
AqueK221_Aque   --------PAIIEKADKVLHGAASTAGLIRI------QATGTSWIYASGVYKPEC-E-VT
AqueK222_Aque   --------VTFLNELYSTFDDILDKFDVYKV------ETIGDAYMVVSGVPRVN-GD-KH
                           :       .          :

HSER_Hsap       AIDIAKMALEILSFMGTFEL-EHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVN
CG10738_Dmel    AAEIATMSLHLLSAVSEFKI-RHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVN
CG9783_Dmel     AEQIATMALDLLHQSGRFNV-KHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN
Gyc32E_Dmel     AGEIASLALHLLETVGNLKI-RHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVN
Gyc76C_Dmel     AGEIASMALELLHAVKQHRI-AHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVN
CG4224_Dmel     AREIARLALALLEAVHNFRI-HHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVN
CG3216_Dmel     AREIALMALDILRAVSSFNL-RHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVN
KSGC_Mmus       ADEIATMALHLLSVTTHFQI-GHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVN
HSER_Mmus       AVDISKMALDILSFIGTFEL-EHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVN
CYGX_Mmus       AAEIANLALDILSYAGNFRM-RHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVN
CYGF_Mmus       AAEIANMSLDILSSVGTFKM-RHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVN
CYGD_Mmus       AAEIANMSLDILSAVGSFRM-RHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVN
ANPb_Mmus       APEIARMALALLDAVSSFRI-RHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVN
ANPa_Mmus       AREVARMALALLDAVRSFRI-RHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVN
odr-1_Cele      IFEVAEISLEIREISYIYVL-QHDKNYKLRIRIGFHAGPIAAGVIGIRSPRYCLFGDTVN
gcy-9_Cele      AQNIADVALKMRAFICNFKL-AHRPEELMMVRIGFHSGPVAAGVVGLAAPRYCLFGDTVN
gcy-8_Cele      INEIASIALDVHKFLSEFIV-PHKRDTKVQCRLGFHTGPVAAAVVGLNAPRYCLFGDTVN
gcy-7_Cele      VRQIALMSLAFLSSLQFFRV-PHLPSERINLRIGMNCGSVVAGVVGLTMPRFCLFGDAVN
gcy-6_Cele      TRNIASMSINFVKSLADFSI-PHLPGEKIKIRVGFHCGSVVAGVVGLTMPRYCLFGDAVN
gcy-5_Cele      IKQIVDMSLKFMDYCKSFKV-PHLPREKVELRIGINSGPCVAGVVGLSMPRYCLFGDTVN
gcy-4_Cele      IRQIVGMSLCFMEFCRNFRI-PHLPRERVELRVGINSGPCVAGVVGLSMPRYCLFGDTVN
gcy-3_Cele      IKQIVDMSLKFMDYCKNFKI-PHLPRERVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVN
gcy-27_Cele     VFEVAEMSLEIRAISLSYTL-ENDKNYKLRVRIGFHAGPIAAGVIGIKNPRYCLFGDTVN
gcy-25_Cele     LREICKISLKLQAFMKTFKV-RHRPSHTLQIKMGITSGAVAAGILGSTAPRFCIFGDTVN
gcy-23_Cele     IRNICNTALELMLLLKTYEI-PHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVN
gcy-22_Cele     AKEISSMSFSLLKAIKTFRV-PHLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVN
gcy-21_Cele     AGEIASLGLALLKAVESFKI-RHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVN
gcy-20_Cele     IRHIARMSLGFLSSLEFFRV-QHLPAERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVN
gcy-2_Cele      IKQIVDMSLKFMEYCRSFKI-PHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVN
gcy-19_Cele     IKQIVELSLDFMSYCKSFKI-PHLPREKVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVN
gcy-18_Cele     SRNIANTALDMRQYLTGYQI-PHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVN
gcy-17_Cele     IKHIARMSLAFLSSLAEFRV-AHMPS------------SVVAGVVGLTMPRYCLFGDAVN
gcy-15_Cele     AGEIASLGLALLKAVESFKI-RHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVN
gcy-14_Cele     IRHIARMSLGFLSSLEFFRV-QHLPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVN
gcy-13_Cele     VANIANMSLELMDSLQAFKI-PHLPQEKVQIRIGMHSGSCVAGVVGLTMPRYCLFGDTVN
gcy-12_Cele     AEQIAMMAIHILSAVRSFSI-PHRSCEPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVN
gcy-11_Cele     AGEVASASLELLDSIKTFTV-SHCPDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVI
gcy-1_Cele      IKQIVDMSLKFMEYCKSFNI-PHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVN
daf-11_Cele     VKSICMIALLQRDCLHHFEI-PHRPGTFLNCRWGFNSGPVFAGVIGQKAPRYACFGEAVI
C04H5.4_Cele    VANISAVTLGIMDLLKVFEV-PHRRDYRLTIRLGFASGQVSAAVVGLSSPRYCLFGETVN
CYGF_Hsap       AAEIANMSLDILSSVGTFKM-RHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVN
ANPb_Hsap       APEIARMALALLDAVSSFRI-RHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVN
ANPa_Hsap       ACEVARMALALLDAVRSFRI-RHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVN
CYGD_Hsap       AAEIANMSLDILSAVGTFRM-RHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVN
T01A4.1_Cele    ANQIAQMSLSLLHKVKNFVI-RHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVN
Npr1_Spur       AREIARMSLALLHEITSFRI-RHRPEERLRLRIGVHTGPVVAGVVGLKMPRYCLFGDTVN
Npr2_Spur       VKEIASMALSLVREAYKFRI-RHKPEEKLLLRVGVHSGACVAGVVGLRMPRYCLFGDTVN
Gcy3_Spur       AAEIASTSLHLLEDVKAFKV-RHRPEVNLKLRIGIHSGSTVSGVVGLTMPRYCLFGDTVN
Npr3_Spur       AREIAQMSLALLGAVTSFKI-RHRPDEQLKLRAGIHSGPCVAGVIGVKMPRYCLFGDTVN
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       AGQIASTAHHLLESVKGFIV-PHKPEVFLKLRIGIHSGSCVAGVVGLTMPRYCLFGDTVN
Gcy2_Spur       AAEIGSTALHLIDEVQKFKI-RHRPDDTLKLRVGIHSGPVVTGVVGLTMPRYCLFGDTVN
Npr5_Spur       AGEIACVALELLTGARQFRI-RHKPDHQLQIRIGINTGPVAAGVVGLTMPRFCLFGDTVN
AqueK220_Aque   VQEVFNCAVKLLL---LFKE--RQSTQKLSVRMSIHLGDLICGVVNETIPFHAAVGAPID
AqueK221_Aque   VVE----SLKAVS---LIKSSLEDSQHKIYPKFAIHQDSVTCGVVNQSAPFHVLLGKASA
AqueK222_Aque   AGEIARMALQLLAASKIFVI-PHKPNTELKIRIGIHSGPVCAGVVGLKMPRYCLFGDTVN


HSER_Hsap       TASRMESTGL------------------PL--------RIHVSGSTIAILKR-TE----C
CG10738_Dmel    TASRMESSGV------------------PL--------KIHCSWQCRQLLDR-L-----G
CG9783_Dmel     TASRMESTGS------------------SW--------RIHMSQETRDRLDA-R-----G
Gyc32E_Dmel     TASRMESTGD------------------SM--------RIHISEATYQLLQV-I-----G
Gyc76C_Dmel     TASRMESNGE------------------AL--------KIHISNKCKLALDK-LG----G
CG4224_Dmel     TASRMESNGE------------------AL--------KIHISETTKEALDE-F-----G
CG3216_Dmel     TASRMESTGQ------------------PG--------KIHVSSATKAILDK-F-----G
KSGC_Mmus       MASRMESSSL------------------PL--------RIHVSQSTAGALLA-A-----G
HSER_Mmus       TASRMESTGL------------------PL--------RIHMSSSTITILKR-TD----C
CYGX_Mmus       TASRMESTGL------------------PY--------RIHVSQSTVQALLS-LD----E
CYGF_Mmus       TASRMESTGL------------------PY--------RIHVSLSTVTILQT-LS----E
CYGD_Mmus       TASRMESTGL------------------PY--------RIHVNMSTVRILRA-LD----Q
ANPb_Mmus       TASRMESNGQ------------------AL--------KIHVSSTTKDALDE-L-----G
ANPa_Mmus       TASRMESNGE------------------AL--------RIHLSSETKAVLEE-F-----D
odr-1_Cele      FASRMQSNCP------------------PN--------QIQTSEITARLLFDS------H
gcy-9_Cele      TASRMESTGV------------------AN--------KIQISEGAYNLLHCF-F----P
gcy-8_Cele      MASRMESNSE------------------PG--------KTQISETAKNLLLKE-Y----P
gcy-7_Cele      TASRMESNGK------------------PG--------KIHVSAEANRMLHL-V-----G
gcy-6_Cele      TASRMESNSKRKIFQKSTNISSSFHLFSAG--------QIHLSEEANQMLMR-L-----G
gcy-5_Cele      TASRMESNGK------------------PS--------MIHMSEAAHSLLTDHYP----H
gcy-4_Cele      TASRMESNGK------------------PS--------MIHMSEAAHSLLVNNYP----Y
gcy-3_Cele      TASRMESNGK------------------PS--------LIHLTSDAHLLLMKHFP----H
gcy-27_Cele     FASRMQSNCP------------------PL--------QIQTSEITARMLLAT------H
gcy-25_Cele     MACRMASTGN------------------PG--------SIQLSELTANTLMEKF-----P
gcy-23_Cele     VASRMESTSE------------------PE--------KIQMSQEARDFCVRY-Y----S
gcy-22_Cele     TASRMESNGK------------------PG--------RVHISTECMKFLTEVI-----G
gcy-21_Cele     TASRMESNGI------------------PL--------RINCSGTAKEILDQ-L-----G
gcy-20_Cele     TASRMESNGK------------------PG--------QIHVTAEANRMLTQVV-----G
gcy-2_Cele      TASRMESNGK------------------PS--------LIHLTSDAHLLLLTHYP----N
gcy-19_Cele     TASRMESNGK------------------GRQMALKSSSHIHLSAASYTLLMKHYP----N
gcy-18_Cele     VSSRMESTGT------------------PG--------MIQMSEEAHMHIRAH-H----P
gcy-17_Cele     TASRMESNGK------------------PG--------RIHVSSEANHLLTHVV-----G
gcy-15_Cele     TASRMESNGIRKFFWVAEPV-------SSL--------RINCSGTAKEILDQ-L-----G
gcy-14_Cele     TASRMESNGK------------------PG--------KIHVTAEANQMLTQVV-----G
gcy-13_Cele     TASRMESNGK------------------PG--------FIHLSSDCYDLLTSLY-----K
gcy-12_Cele     TASRMESNGE------------------AL--------RIHCSSSTQKVLTS-ID----Q
gcy-11_Cele     IANMMESSGE------------------PM--------RIQISSDAYELILK-C-----G
gcy-1_Cele      TASRMESNGK------------------PS--------LIHLTNDAHSLLTTHYP----N
daf-11_Cele     LASKMESSGV------------------ED--------RIQMTLASQQLLEEN-F----P
C04H5.4_Cele    IAAVMESSGE------------------GG--------RVQITETSKILLENE-Y----P
CYGF_Hsap       TASRMESTGL------------------PY--------RIHVSLSTVTILQN-LS----E
ANPb_Hsap       TASRMESNGQ------------------AL--------KIHVSSTTKDALDE-L-----G
ANPa_Hsap       TASRMESNGE------------------AL--------KIHLSSETKAVLEE-F-----G
CYGD_Hsap       TASRMESTGL------------------PY--------RIHVNLSTVGILRA-LD----S
T01A4.1_Cele    TSSRMESNGL------------------RM--------FWNFSLYKIYKFKV-FKNKIEL
Npr1_Spur       TASRMESNGE------------------AM--------KIHLSNQTKKILEL-F-----G
Npr2_Spur       TASRMESTGQ------------------AM--------KVHISESTKKLLDT-F-----K
Gcy3_Spur       TASRMESNGE------------------AL--------KIHTSSETKNLLEQ-M-----G
Npr3_Spur       TTSRMESTGE------------------AL--------KIHTSLTCKTILDK-F-----Q
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       TASRMESNGL------------------AL--------RIHVSPWCKQVLDK-L-----G
Gcy2_Spur       TSSRMESNGE------------------AL--------KIHCSAECKAILDE-V-----G
Npr5_Spur       TASRMESNSL------------------PQ--------KIHCSSDSAAVLKE-L-----G
AqueK220_Aque   DATQLMIQCP------------------VN--------AVLISERAKNDLPNR-M----G
AqueK221_Aque   SALSILHHCP------------------DN--------GIIVSEPVKLCLSKN-------
AqueK222_Aque   TASRMESNSE------------------AM--------KIHCSNDTAQLLKK-V-----G


HSER_Hsap       QFLYEVRGETYLK-----------------------------------------------
CG10738_Dmel    GYHFAERGVISMK-----------------------------------------------
CG9783_Dmel     GYAIEPRGLIDIK-----------------------------------------------
Gyc32E_Dmel     SYVCIERGLTSIK-----------------------------------------------
Gyc76C_Dmel     GYITEKRGLVNMK-----------------------------------------------
CG4224_Dmel     TFVTTRRGFVPMK-----------------------------------------------
CG3216_Dmel     TFQMEQRGDVELK-----------------------------------------------
KSGC_Mmus       GYHLQKRGTISVK-----------------------------------------------
HSER_Mmus       QFLYEVRGETYLK-----------------------------------------------
CYGX_Mmus       GYKIDVRGQTELK-----------------------------------------------
CYGF_Mmus       GYEVELRGRTELK-----------------------------------------------
CYGD_Mmus       GFQMECRGRTELK-----------------------------------------------
ANPb_Mmus       CFQLELRGDVEMK-----------------------------------------------
ANPa_Mmus       GFELELRGDVEMK-----------------------------------------------
odr-1_Cele      EYKFVKRGIVHVK-----------------------------------------------
gcy-9_Cele      QFQMVERGKIEVK-----------------------------------------------
gcy-8_Cele      DYICEQRGEIPIK-----------------------------------------------
gcy-7_Cele      GFDTESRGEVIIK-----------------------------------------------
gcy-6_Cele      GFTTEPRGEVIIK-----------------------------------------------
gcy-5_Cele      QYETSSRGEVIIK-----------------------------------------------
gcy-4_Cele      QFETNSRGEVIIK-----------------------------------------------
gcy-3_Cele      QYETNSRGEVIIK-----------------------------------------------
gcy-27_Cele     EYKLVKRGIVHVK-----------------------------------------------
gcy-25_Cele     SFMLEERGMIDVK-----------------------------------------------
gcy-23_Cele     EFQITLRGTVEAK-----------------------------------------------
gcy-22_Cele     GYQTEPRGEVIVK-----------------------------------------------
gcy-21_Cele     GYEIEERGIVEMK-----------------------------------------------
gcy-20_Cele     GFRTESRGEVIIK-----------------------------------------------
gcy-2_Cele      HYDTSSRGEVIIK-----------------------------------------------
gcy-19_Cele     QYNTASRGDVIIK-----------------------------------------------
gcy-18_Cele     VFTTTERGEVQVK-----------------------------------------------
gcy-17_Cele     GFRTEERGEVIIK-----------------------------------------------
gcy-15_Cele     GYEIEERGIVEMK-----------------------------------------------
gcy-14_Cele     GFRTESRGEVIIK-----------------------------------------------
gcy-13_Cele     EYNTESRGEVIIK-----------------------------------------------
gcy-12_Cele     GFLLEERGSLAIK-----------------------------------------------
gcy-11_Cele     GYVTEQREKIVLK-----------------------------------------------
gcy-1_Cele      QYETSSRGEVIIK-----------------------------------------------
daf-11_Cele     QFVCSNRGGRTIE-----------------------------------------------
C04H5.4_Cele    EFIIEIRGINKDV-----------------------------------------------
CYGF_Hsap       GYEVELRGRTELK-----------------------------------------------
ANPb_Hsap       CFQLELRGDVEMK-----------------------------------------------
ANPa_Hsap       GFELELRGDVEMK-----------------------------------------------
CYGD_Hsap       GYQVELRGRTELK-----------------------------------------------
T01A4.1_Cele    DFLKNEKESIEFE-----------------------------------------------
Npr1_Spur       TFILELRGEVEMK-----------------------------------------------
Npr2_Spur       NFETEPRGEVVLKAYRVPPCPKMSADGGERRGHTVVRYQSGQHVNRALALIYTRWDPAKV
Gcy3_Spur       GFVVEERGLISMK-----------------------------------------------
Npr3_Spur       IFVLELRGLVEMK-----------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       GYELEDRGLVPMK-----------------------------------------------
Gcy2_Spur       GYDVPERGIVAMK-----------------------------------------------
Npr5_Spur       GYVLEKRGLITIK-----------------------------------------------
AqueK220_Aque   LKKFDK------------------------------------------------------
AqueK221_Aque   -YQLEYID-AIME-----------------------------------------------
AqueK222_Aque   GFQLECRGTLEIK-----------------------------------------------


HSER_Hsap       ---------------------------GRGN-ETTYWLTGMKDQKFNLPTP---------
CG10738_Dmel    ---------------------------GKGD-QRTYWLLGEDEEARTRRTY---------
CG9783_Dmel     ---------------------------GKGM-MNTFWLLGKKGFDKPLPAP---------
Gyc32E_Dmel     ---------------------------GKGD-MRTYWLTKRQQPELTPDLI---------
Gyc76C_Dmel     ---------------------------GKGD-VVTWWLTGANENAIQKKLV---------
CG4224_Dmel     ---------------------------GKGE-MLTYWLEGEVPRPNSLISPSKLMLTRRS
CG3216_Dmel     ---------------------------GKGT-VTTYWLNSTSEGEARPPTP---------
KSGC_Mmus       ---------------------------GKGE-QTTFWLKGKDGFPVPL--P---------
HSER_Mmus       ---------------------------GRGT-ETTYWLTGMKDQEYNLPSP---------
CYGX_Mmus       ---------------------------GKGL-EETYWLTGKVGFCRPLPTP---------
CYGF_Mmus       ---------------------------GKGT-EETFWLVGKKGFTKPLPVP---------
CYGD_Mmus       ---------------------------GKGI-EDTYWLVGRLGFNKPIPKP---------
ANPb_Mmus       ---------------------------GKGK-MRTYWLLGEQKGP---------------
ANPa_Mmus       ---------------------------GKGK-VRTYWLLGERGC----------------
odr-1_Cele      ---------------------------GKGN-AARLKICCETFE----------------
gcy-9_Cele      ---------------------------VSEK-SEK---------KAT-------------
gcy-8_Cele      ---------------------------GKGL-CMTYWLMGTKSEGSGRSGA---------
gcy-7_Cele      ---------------------------GKGV-METFWLTGQGTGAVSGARH---------
gcy-6_Cele      ---------------------------GKGV-MATYWLLKMDESAAP-------------
gcy-5_Cele      ---------------------------GKGV-METFWVLGKTDSDTKSLS----------
gcy-4_Cele      ---------------------------GKGV-METYWLLGKMSLSNQST-----------
gcy-3_Cele      ---------------------------GKGV-METFWVLGRSGDIE-PSIS---------
gcy-27_Cele     ---------------------------GKGE-VNCYWLNEHIHKDEE-------------
gcy-25_Cele     ---------------------------GKGA-CLTFWLTGEKDIMRRQSSR---------
gcy-23_Cele     ---------------------------GKGP-VTSYWLLGKQSESQM-------------
gcy-22_Cele     ---------------------------GKGA-VQTHWLLTDDEIEA--------------
gcy-21_Cele     ---------------------------GKGK-QMTYFVRGENSDMRRERII---------
gcy-20_Cele     ---------------------------GKGV-METFWLLGEESGYTAPSKA---------
gcy-2_Cele      ---------------------------GKGV-METFWVHGRIDDIAEPTEL---------
gcy-19_Cele     ---------------------------GKGV-METFWVFERNNQFMGVSSN---------
gcy-18_Cele     ---------------------------GKGT-CRTFWLEDRVGDAST-------------
gcy-17_Cele     ---------------------------GKGV-MNTYWLLGENDSVPVKSNM---------
gcy-15_Cele     ---------------------------GKGK-QMTYFVRGENSDMRRERII---------
gcy-14_Cele     ---------------------------GKGV-METYWLLGEQSRISVSAQA---------
gcy-13_Cele     ---------------------------GKGV-MQTYWLLGMKE-----------------
gcy-12_Cele     ---------------------------GKGQ-MTTYWLNGRAGYEFTE-TI---------
gcy-11_Cele     ---------------------------NKLE-VMTYWMNDYSKDARLARLV---------
gcy-1_Cele      ---------------------------GKGV-METFWVHGRFGEME-PTEL---------
daf-11_Cele     ---------------------------GIGR-ILTYWLEGVNAGEQVKVVE---------
C04H5.4_Cele    ---------------------------KQDD-FVTYWLTGKDEDYFK-------------
CYGF_Hsap       ---------------------------GKGT-EETFWLIGKKGFMKPLPVP---------
ANPb_Hsap       ---------------------------GKGK-MRTYWLLGERKGP---------------
ANPa_Hsap       ---------------------------GKGK-VRTYWLLGERGS----------------
CYGD_Hsap       ---------------------------GKGA-EDTFWLVGRRGFNKPIPKP---------
T01A4.1_Cele    ---------------------------GKKM-----------------------------
Npr1_Spur       ---------------------------GKGT-QTTFWLKGERG-----------------
Npr2_Spur       LGMFKTLAGWHRPQVSGKRTVLNGMRTGKGS-QQTYWLTAEASTSVI-------------
Gcy3_Spur       ---------------------------GKGQ-LVTYWLISADPSYRRSSPF---------
Npr3_Spur       ---------------------------GKGQ-QTTFWLLSQKDN----------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ---------------------------GKGE-IHTFWLLGQDPSYKITKVK---------
Gcy2_Spur       ---------------------------GKGS-LLTYWLVDQDPSYKRFKPR---------
Npr5_Spur       ---------------------------GKGQ-MTTYWLLGTDTTIRPRYSI---------
AqueK220_Aque   ----------------------------KNEDVVAYIVTAEDCVAMSE------------
AqueK221_Aque   ---------------------------EDGN-SLPYYSYSAPFADLST------------
AqueK222_Aque   ---------------------------GKGQ-MTTWWLKGEDKPSSSSSRR---------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     ------------------------------------------------------------
CG4224_Dmel     SLKQPQRSQSHNLHKQYSELVVASPPPQLPPPAIALPPPPSPSKDSPNLRVKRKISSSSP
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     ------------------------------------------------------------
CG4224_Dmel     KLNGGGFDYHKTENHYLDTAAAAQRNCDIYSSRSLRDMEETSDSWELAHFRLPLSGALKS
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     ------------------------------------------------------------
CG4224_Dmel     HHHLNNNSHGYVHSNSSSNLSGILQPPPLGVQRTRLKPSPTISTLLTSARSEANASPGPE
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     ------------------------------------------------------------
CG4224_Dmel     TGSMGSGQLRIKFAEGDETPLLPTPPPLAAPPPIPQMVAASPQRSGSGQNIPADSSHYGF
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------------P-----------------------------T-----------
CG10738_Dmel    ------------------E-----------------------------R-----------
CG9783_Dmel     ------------------P-----------------------------P-----------
Gyc32E_Dmel     ------------------S-----------------------------T-----------
Gyc76C_Dmel     ------------------D-----------------------------M-----------
CG4224_Dmel     LVKSYKQQCPPVAGSAVTQ-----------------------------------------
CG3216_Dmel     ------------------Q-----------------------------I-----------
KSGC_Mmus       ------------------E-----------------------------F-----------
HSER_Mmus       ------------------P-----------------------------T-----------
CYGX_Mmus       ------------------L-----------------------------S-----------
CYGF_Mmus       ------------------P-----------------------------P-----------
CYGD_Mmus       ------------------P-----------------------------D-----------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------Y------------------------LAPS-------------
gcy-7_Cele      ------------------V----------------------SAKK---------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      -----------------------------------------TRTTPP-I-----------
gcy-4_Cele      ---------------------------------------------PP-I-----------
gcy-3_Cele      -----------------------------------------NRSTPP-V-----------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------S-----------------------------S-----------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------R-----------------------------E-----------
gcy-20_Cele     ------------------A----------------------PKV----------------
gcy-2_Cele      ------------------R--------S-----------IC---KPSTV-----------
gcy-19_Cele     ------------------S--------GYQSDKKATNNGSSPESTPP-S-----------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------R-----------------------------------------
gcy-15_Cele     ------------------R-----------------------------E-----------
gcy-14_Cele     ------------------P----------------------REKTPE-------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------E-----------------------------D-----------
gcy-11_Cele     ------------------A-----------------------------H-----------
gcy-1_Cele      ------------------R--------S-----------ISNRSTPP-V-----------
daf-11_Cele     ------------------FQNDLNDELSRIMKKDGELLAAATALKPK-DKMTLAKEKVIA
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------P-----------------------------P-----------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------P-----------------------------D-----------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------A-----------------------------------------
Gcy3_Spur       ------------------R-----------------------------T-----------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------S-----------------------------E-----------
Npr5_Spur       ------------------D-----------------------------T-----------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       --------VENQQR--L-------------------------------------------
CG10738_Dmel    --------SQRRGS--R-------------------------------------------
CG9783_Dmel     --------IGLDES--L-------------------------------------------
Gyc32E_Dmel     --------VDTLDT--Y-------------------------------------------
Gyc76C_Dmel     ------------------------------------------------------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     --------LTTD-E--V-------------------------------------------
KSGC_Mmus       --------TE--------------------------------------------------
HSER_Mmus       --------VENQQR--L-------------------------------------------
CYGX_Mmus       --------IKP-GD--P-------------------------------------------
CYGF_Mmus       --------VGKDGQ--V-------------------------------------------
CYGD_Mmus       --------LQP-GA--S-------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      --------I---------------------------------------------------
gcy-8_Cele      --------MKSAGT--G-------------------------------------------
gcy-7_Cele      --------VSKKV---------------------C-------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      --------TDENWPPQM-------------KEDLK-------------------------
gcy-4_Cele      --------TKVNHKPRKIA--SFT--DS-ELTNYS-------------------------
gcy-3_Cele      --------TQERFTVRA-------------PDTPE-------------------------
gcy-27_Cele     --------IEE-------------------------------------------------
gcy-25_Cele     --------CISQIK--FE------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     --------RVKFAS--L-----------------KKAQIQEKTYEFSLNKLFIVKSFLKL
gcy-20_Cele     --------IQHRQ---------------------S-------------------------
gcy-2_Cele      --------ANERWITPP-------------APKPE-------------------------
gcy-19_Cele     --------TPPMHEVKANSPVRHRKPPSPSSPTLS-------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ----------KRE---------------------N-------------------------
gcy-15_Cele     --------RVKFAS--L-------------------------------------------
gcy-14_Cele     --------PPRRQ---------------------S-------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     --------KMVVPD-IF-----------------PRPNLKNRGS----------------
gcy-11_Cele     --------QEKFP-----------------------------------------------
gcy-1_Cele      --------TNDRWIPN--------------------------------------------
daf-11_Cele     ERKNEEERLQRQQ---T-------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       --------VDKDGQ--V-------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       --------LQP-GS--S-------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       --------AEENAT--V-------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       --------DVEEA---V-------------------------------------------
Npr5_Spur       --------AVSKK---I-------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------Q-A------------------------EFS------------------
CG10738_Dmel    ------------ALN------------------------KFI------------------
CG9783_Dmel     ------------I-R------------------------NSITLKAQANKSRTSTNPSSS
Gyc32E_Dmel     -------------CS------------------------G--------------------
Gyc76C_Dmel     ------------------------------------------------------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------Q-T------------------------EFS------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     LIRYLQMRRHPIS-----------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ----------SWA-----------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------GLF------------------------DST------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------EDT------------------------DSL------------------
Npr5_Spur       ------------STDTMISQDSLLSPSHRMSDAYDIPEDRLI------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       --------------------------------------------D---------------
CG10738_Dmel    --------------------------------------------Q---------------
CG9783_Dmel     QSSSLAGESVEVKVEITPPTNADLASGTNLPNSYSLDSNSTNTIS----PNATLCPEFPG
Gyc32E_Dmel     -------------------------------------------------PR-E-------
Gyc76C_Dmel     -------------------------------------------------------MDM--
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       --------------------------------------------D---------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       --------------------------------------------HGNHSNR-H-------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------------------------------------SEK-H-------
Npr5_Spur       --------------------------------------------E----EHMNKTDNA--
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    -------------------G--TIKQ----AQEQ---ANEYGI------RS--------S
CG9783_Dmel     KTTPSSTSPQSRK-----LS--ELTPENLLNP----------------------------
Gyc32E_Dmel     -------------------S-MEVSV----HQY----CSPASNNY----RLGSCNCDTKC
Gyc76C_Dmel     ---PPP-------------LFSRPRK----SPK---------------------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       --------WQDRI-----NQ--EIRT----------------------------------
CYGF_Mmus       --------GHGLQ-----PA--EIAA----------------------------------
CYGD_Mmus       --------NHGIS-----LQ--EIPP----------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------FT--GMLG----------------------------------
gcy-7_Cele      ------------------LD-IQITY----------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------KR--AVTP----------------------------------
gcy-4_Cele      ------------------FR--SVSP----------------------------------
gcy-3_Cele      ------------------AR--SVSS----------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------LD--EADN----------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     --------NHNVVTVKTCMR--TIPP----------------------------------
gcy-20_Cele     ------------------IR--SISP----------------------------------
gcy-2_Cele      ------------------IR--SVSS----------------------------------
gcy-19_Cele     ------------------KR--SVSP----------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------T-----------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------VR--SISP----------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     --------NRLTALVPACPF--QRPS----------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ----------------------PSSS----------------------------------
daf-11_Cele     ------------------LQ--EALE----------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       --------GHGLQ-----PV--EIAA----------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       --------NHGIS-----LQ--EIPP----------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       -------------------S--KISA----QPQ----KEPFAKRLEADGRP---------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ---PPP-------------Q--KLTQ------E---------------------------
Gcy2_Spur       ----------------------KMKK----SPGKSYLRTPLGSTY---MAP--------S
Npr5_Spur       ---PRP-------------S--TIAE----KRE----ST---------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ----II-------------V--KSSG----GTE---------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    L-----------------------------------------------------------
CG9783_Dmel     -----------------------------------------------------------N
Gyc32E_Dmel     L-----------------------------------------------------------
Gyc76C_Dmel     LNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSLQGSVRESPRMV-----------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       -A------------------------------------------NPNVCH----------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       TS------------------------------------------TPTTGM----------
Npr5_Spur       SA------------------------------------------RPSVREHTDDQLMSEA
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   L-----------------------------------------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     SFNRL-------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     -----SKRDRD--------------RERPPINGLGAGHFVGGALLESAQASLSTLNHSET
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       DSRRIS----TGSWTDGGQESVRFGRSITPVKG---------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     NETNCDMDGGSGGVSGSGSGLVRQPNALHKPLAMVRPHRIISAAQLPQLGDNDDDSADTL
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     -YS---------------------------------------------------------
Gyc76C_Dmel     L--------RESRS----------------------------------------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       -NDSDSAIWFHYLTITIP------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       -KS---------------------------------------------------------
Npr5_Spur       LH--------------VPSRLADNNQAAIMDERAGDGVRPSYVTDDRATPLGKESGDEGG
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       --------------------MI--------------------------------------
CG10738_Dmel    -----------------------------------------KQKNLP-------------
CG9783_Dmel     ----------------------------------------------PSSTGGSSSRLYKK
Gyc32E_Dmel     -------------------------R--------------RSDDNVT-------------
Gyc76C_Dmel     ------------------------------------------LDPM--------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       --------------------MI--------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       -------------------------ERIVNSEHAFLFITGGSTKSSP-------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       -------------------------S--------------RSVQDIS-------------
Npr5_Spur       YDNPVMDPRGTVIEEKEESHSVTSPQ--------------HSLSPAP-------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   -------------------------------------------YS---------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     IEEMMDLSSPYNHYKCLSPSESNLTQFYDGKYLYGSVAGGAGGGQAGGGACASIALSGSG
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     ------------------------------------------------------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       -------------A----N-----SL----------------------------------
CG10738_Dmel    --------------RN--------------------------------------------
CG9783_Dmel     CGGGASRFDSKPGS----SRLLRRQFSLDRDDQQAKGEQQHHQHSLQANTYSGLVGGCGG
Gyc32E_Dmel     --------------NS--------------------------------------------
Gyc76C_Dmel     ------------------P-----MQ----------------------------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       -------------V----S-----AL----------------------------------
CYGX_Mmus       ------------------------GF----------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       --------------PDPRT-----DK----------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       -------------SSNLRE-----DA----------------------------------
Npr5_Spur       --------------PSKS------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------E-----GA----------------------------------


HSER_Hsap       -----------------------------------------------Q-KRQ--------
CG10738_Dmel    -----------------------------------------------S-LTR--------
CG9783_Dmel     GVKSSMLDIPLLHDTTRSPKGTLTRSHKQNSASITQD----------L--EK--------
Gyc32E_Dmel     -----------------------------------------------HGTSE--------
Gyc76C_Dmel     -----------------------------------------------Q-LRK--------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       -----------------------------------------------Q-KRQ--------
CYGX_Mmus       ----------------------------------A-K----------A-RQG--------
CYGF_Mmus       ------------------------------------F----------Q-RRK--------
CYGD_Mmus       ------------------------------------E----------R-RKK--------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------N----------S-AND--------
gcy-7_Cele      ------------------------------------FCFKM-YEEF-Q-MDE--------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ---------------------------------------------Y-P---E--------
gcy-4_Cele      ------------------------------------YVEN-L-SDNDD---E--------
gcy-3_Cele      ------------------------------------HGSR-PSSNHNN---N--------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     -----------------------------------------------S-KKMF-------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------Q----------E-VYI--------
gcy-20_Cele     ------------------------------------ILEKN-AEGS-E-TSS--------
gcy-2_Cele      ------------------------------------HGSR-PPSVYDP---L--------
gcy-19_Cele     ------------------------------------IMEAKARDIHNE-ETE--------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------IIEKM-SEET-Q-KGL--------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------D----------H-MNL--------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------HGSR-PSSVYDP---L--------
daf-11_Cele     ------------------------------------E----------H-EEEIEMNEVLV
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------F----------Q-RRK--------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------E----------R-RRK--------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       -----------------------------------------------E-IRR--------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       -----------------------------------------------Q-LRR--------
Npr5_Spur       -------------------------------------------------VSP--------
AqueK220_Aque   --------------------------------------------------DQ--------
AqueK221_Aque   --------------------------------------------------SK--------
AqueK222_Aque   -----------------------------------------------Q-LRS--------


HSER_Hsap       ------------------A--AGI----------------------RS----------Q-
CG10738_Dmel    ------------------SSS--L----------------------------------E-
CG9783_Dmel     ------------------------I-EEIPLSPASSQHHSSLDSNLN-----------RS
Gyc32E_Dmel     ------------------FPK--V----------------------------------S-
Gyc76C_Dmel     ------------------R-----------------------------------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------A--SGK----------------------KS----------R-
CYGX_Mmus       -----------------------LA-----------------------------------
CYGF_Mmus       ------------------------A-----------------------------------
CYGD_Mmus       ------------------------L-----------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------I-----------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------R-----------------------------------
gcy-4_Cele      ------------------------E-----------------------------------
gcy-3_Cele      ------------------------N-----------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------LN----------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------SS----T-----------------------------------
gcy-20_Cele     ------------------------L-----------------------------------
gcy-2_Cele      ------------------------Q-----------------------------------
gcy-19_Cele     ------------------------A-----------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------Y-----------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     -------------------R----F-----------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------Q-----------------------------------
daf-11_Cele     DEDEGEGKPKEVDLTSIVSTQMEELED---------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------A-----------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------L-----------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------TSN--I----------------------A-------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------DSD--V----------------------VTRRRNSDISRTE-
Npr5_Spur       ------------------SSSDGD----------------------------------K-
AqueK220_Aque   ------------------------E-----------------------------------
AqueK221_Aque   ------------------------V-----------------------------------
AqueK222_Aque   ------------------S-----------------------------------------


HSER_Hsap       KPR--------------------R------------------------------------
CG10738_Dmel    SPK---------------------------------------------------------
CG9783_Dmel     PPS--------------------T------------------------------------
Gyc32E_Dmel     EPA---------------------------------------------------------
Gyc76C_Dmel     --------------HDRVKLPPSKLSKN----------------NSRSLDTGVSLISGNP
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       RPT--------------------R------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     LP----------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     EP----------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     EP----------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------VG----------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       LPKNGKNGYTLLPMDCDDSLPCSKSEEVEIRTTDFGDGSGDCSSQARSVS----------
Npr5_Spur       KRR---------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     NGEVHSSQLDLDNEMTANPVDATDGYDDELGLLMRHDNGQLPALRYSGSFPNAQISIVPT
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       ------------------------------------------------------------
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       ------------------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------------------------------------------------------------
Gyc32E_Dmel     ------------------------------------------------------------
Gyc76C_Dmel     GRSAGGGGGGREGGGSNCAKHLNNNCNGGVNVEDDLESPL-LQR----------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------------------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ------------------------------------------------------AGIVGA
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       --------------------------------------ACSLNRCEVVGEEATMNGAVSQ
Npr5_Spur       ------------------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   ------------------------------------------------------------


HSER_Hsap       -VA-------------------------------------------S-YK----------
CG10738_Dmel    KLR-------------------------------------------F-AAG-S-------
CG9783_Dmel     -LEAQSPPLPPMSPPQLSAPTSPAPSRTLNGIYAHNSNSTSSHGAAN-NN----------
Gyc32E_Dmel     QVN-------------------------------------------C-NQL-C-VCRLNS
Gyc76C_Dmel     Q-----------------------------------------------------------
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       -VA-------------------------------------------S-YK----------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       TLR-------------------------------------------QV-----------P
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       AI----------------------------------------------------------
Gcy2_Spur       RSR-------------------------------------------NNSQG-S------K
Npr5_Spur       NLR-------------------------------------------S-GARTENNNYLSP
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   S-----------------------------------------------------------


HSER_Hsap       ------KGT---------------------------------------------------
CG10738_Dmel    ------------------------------------------------------------
CG9783_Dmel     ------NGT---------------------------------------------------
Gyc32E_Dmel     SQMFN-------------------------------------------------------
Gyc76C_Dmel     -ASLSV-----PPEEMLAHNKRWHSLEHMDGPGGHGGNSVSYAADIDNRHPGDLDFFSGS
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ------KGF---------------------------------------------------
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      ------------------------------------------------------------
gcy-7_Cele      ------------------------------------------------------------
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ------------------------------------------------------------
gcy-4_Cele      ------------------------------------------------------------
gcy-3_Cele      ------------------------------------------------------------
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ------------------------------------------------------------
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ------------------------------------------------------------
gcy-20_Cele     ------------------------------------------------------------
gcy-2_Cele      ------------------------------------------------------------
gcy-19_Cele     ------------------------------------------------------------
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     ------------------------------------------------------------
gcy-14_Cele     ------------------------------------------------------------
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ------------------------------------------------------------
gcy-11_Cele     ------------------------------------------------------------
gcy-1_Cele      ------------------------------------------------------------
daf-11_Cele     ------------------------------------------------------------
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       NQ--P-------------------------------------------------------
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       ------------------------------------------------------------
Gcy2_Spur       TK--TKKNSTTD------------------------------------------------
Npr5_Spur       AK--R-KNA---------------------------------------------------
AqueK220_Aque   ------------------------------------------------------------
AqueK221_Aque   ------------------------------------------------------------
AqueK222_Aque   -AVLRT------------------------------------------------------


HSER_Hsap       ----------------------------------------------------L------E
CG10738_Dmel    ----------------------------------------------------L------L
CG9783_Dmel     ----------------------------------------------------H------P
Gyc32E_Dmel     ----------------------------------------------------N------R
Gyc76C_Dmel     SNQHHRSKAAGGSKLTNWMTNIFKGNGVRSGEARRVGILPSGVHGARTGFTDM------A
CG4224_Dmel     ------------------------------------------------------------
CG3216_Dmel     ------------------------------------------------------------
KSGC_Mmus       ------------------------------------------------------------
HSER_Mmus       ----------------------------------------------------L------E
CYGX_Mmus       ------------------------------------------------------------
CYGF_Mmus       ------------------------------------------------------------
CYGD_Mmus       ------------------------------------------------------------
ANPb_Mmus       ------------------------------------------------------------
ANPa_Mmus       ------------------------------------------------------------
odr-1_Cele      ------------------------------------------------------------
gcy-9_Cele      ------------------------------------------------------------
gcy-8_Cele      -----------------------------------------------------------Y
gcy-7_Cele      ----------------------------------------------------H------R
gcy-6_Cele      ------------------------------------------------------------
gcy-5_Cele      ----------------------------------------------------Q------R
gcy-4_Cele      ----------------------------------------------------I------R
gcy-3_Cele      ----------------------------------------------------D------P
gcy-27_Cele     ------------------------------------------------------------
gcy-25_Cele     ----------------------------------------------------P------Y
gcy-23_Cele     ------------------------------------------------------------
gcy-22_Cele     ------------------------------------------------------------
gcy-21_Cele     ----------------------------------------------------Y---EDSE
gcy-20_Cele     ----------------------------------------------------S------V
gcy-2_Cele      ----------------------------------------------------D------H
gcy-19_Cele     ----------------------------------------------------L------Y
gcy-18_Cele     ------------------------------------------------------------
gcy-17_Cele     ------------------------------------------------------------
gcy-15_Cele     -----------------------------------------------------------K
gcy-14_Cele     ----------------------------------------------------S------A
gcy-13_Cele     ------------------------------------------------------------
gcy-12_Cele     ----------------------------------------------------S----NLS
gcy-11_Cele     ---------------------------------------------------------HLE
gcy-1_Cele      ----------------------------------------------------G------H
daf-11_Cele     ----------------------------------------------------AGRTIGHG
C04H5.4_Cele    ------------------------------------------------------------
CYGF_Hsap       ------------------------------------------------------------
ANPb_Hsap       ------------------------------------------------------------
ANPa_Hsap       ------------------------------------------------------------
CYGD_Hsap       ------------------------------------------------------------
T01A4.1_Cele    ------------------------------------------------------------
Npr1_Spur       ------------------------------------------------------------
Npr2_Spur       ------------------------------------------------------------
Gcy3_Spur       ----------------------------------------------------I------V
Npr3_Spur       ------------------------------------------------------------
Npr4_Spur       ------------------------------------------------------------
Gcy1_Spur       -----------------------------------------------------------E
Gcy2_Spur       -----------------------SGI----------------------GSNGN------S
Npr5_Spur       ----------------------------------------------------I------T
AqueK220_Aque   -----------------------------------------------------------K
AqueK221_Aque   -----------------------------------------------------------S
AqueK222_Aque   ----------------------------------------------------P------N


HSER_Hsap       Y-LQLNTTDKESTYF
CG10738_Dmel    ---EHHRYHRFDNIY
CG9783_Dmel     G-PELTLNAEQLLSR
Gyc32E_Dmel     ---GPRSAPSITFRL
Gyc76C_Dmel     ---ASAAARDRESIV
CG4224_Dmel     -------PLLAKINS
CG3216_Dmel     ---P-FPLLFAGMGK
KSGC_Mmus       ------EEAKVSEIL
HSER_Mmus       Y-MQLNNSDHDSTYF
CYGX_Mmus       ---EPRKSGEAGPGP
CYGF_Mmus       ---E-R--QLVRNKP
CYGD_Mmus       ---E-KARPGQFTGK
ANPb_Mmus       -----------PGLL
ANPa_Mmus       -----------STRG
odr-1_Cele      ---------THSIDL
gcy-9_Cele      -----IYNYREKESV
gcy-8_Cele      ---SLNLKNPTGLQR
gcy-7_Cele      ---QETLKSDEQLSD
gcy-6_Cele      -------KILKKKQD
gcy-5_Cele      ---SGKSKMDTLKVV
gcy-4_Cele      ---RVLRREMMRVEV
gcy-3_Cele      ---LYRQYKMDTLKI
gcy-27_Cele     -----SGTISHPLES
gcy-25_Cele     ---ISIITSLVSGNN
gcy-23_Cele     -----QQQNFSQLGI
gcy-22_Cele     --------KENGESI
gcy-21_Cele     ---EEASTVYDTVTY
gcy-20_Cele     ----DQAGDNNSETV
gcy-2_Cele      ---RKFKMDTLKVAN
gcy-19_Cele     ---RQFRRQETLALI
gcy-18_Cele     -----TNYIQNVEGV
gcy-17_Cele     ----PSMARSITPEI
gcy-15_Cele     ---KAQIQEKTYEFS
gcy-14_Cele     ---YKDFNNGNECVS
gcy-13_Cele     ------------ESA
gcy-12_Cele     ---SSDSTSEEYLNN
gcy-11_Cele     ----HLIHKFNKGVR
gcy-1_Cele      ---QKFKMDTLKVAN
daf-11_Cele     ---RLDSQASTIPDN
C04H5.4_Cele    -------KKNNTFDF
CYGF_Hsap       ---E-R--QLVRNKP
ANPb_Hsap       -----------PGLL
ANPa_Hsap       -----------STRG
CYGD_Hsap       ---E-KAR--PGQFS
T01A4.1_Cele    ----------VTEFN
Npr1_Spur       -------------CS
Npr2_Spur       -------CPVTKVEV
Gcy3_Spur       ---FKVTLSRKDMKI
Npr3_Spur       ------------DKG
Npr4_Spur       --------------E
Gcy1_Spur       ----IAANRVIPDDV
Gcy2_Spur       ---SRDCNMHNEIFL
Npr5_Spur       LHSSGSSGKAGVSKA
AqueK220_Aque   ---F-DSVANPLDKI
AqueK221_Aque   ---LTLSTGSKSQCE
AqueK222_Aque   ---RVIINIPGTPMQ