Protein (view, download) , Domain (view, download)
MEKK15_Hsap_MEKK15                  WTK---GE-ILGKGAYGTVYCGLT-S-QGQLIAVKQVALDTSN--------K--------
MAP3K7_Hsap_ASK                     HDANGERV-VLGKGTYGIVYAGRDLS-NQVRIAIKEIPERD-------------------
MAP3K6_Hsap_ASK                     YTETGERL-VLGKGTYGVVYAGRDRH-TRVRIAIKEIPERD-------------------
MAP3K5_Hsap_ASK                     YDENGDRV-VLGKGTYGIVYAGRDLS-NQVRIAIKEIPERD-------------------
MAP3K4_Hsap_MEKK4                   WQR---GN-KIGEGQYGKVYTCISVD-TGELMAMKEIRFQPND-----------------
MAP3K3_Hsap_MEKK2                   WRR---GK-LLGQGAFGRVYLCYDVD-TGRELASKQVQFDPDS--------P--------
MAP3K2_Hsap_MEKK2                   WRL---GK-LLGQGAFGRVYLCYDVD-TGRELAVKQVQFDPDS--------P--------
MAP3K1_Hsap_MEKK1                   WLK---GQ-QIGLGAFSSCYQAQDVG-TGTLMAVKQVTYVRNT--------S--------
MEKK15_Mmus_MEKK15                  WTK---GE-ILGRGAYGTVYCGLT-S-LGQLIAVKQVALDTSD--------K--------
MAP3K7_Mmus_ASK                     HDANGERV-VLGKGSYGIVYAGRDLS-NQVRIAIKEIPERD-------------------
MAP3K6_Mmus_ASK                     YSETGERL-VLGRGTYGVVYAGRDRH-TRVRIAIKEIPERD-------------------
MAP3K5_Mmus_ASK                     YDENGDRV-VLGKGTYGIVYAGRDLS-NQVRIAIKEIPERD-------------------
MAP3K4_Mmus_MEKK4                   WQR---GN-KIGEGQYGKVYTCISVD-TGELMAMKEIRFQPND-----------------
MAP3K3_Mmus_MEKK2                   WRR---GK-LLGQGAFGRVYLCYDVD-TGRELASKQVQFDPDS--------P--------
MAP3K2_Mmus_MEKK2                   WRL---GK-LLGQGAFGRVYLCYDVD-TGRELAVKQVQFNPES--------P--------
MAP3K1_Mmus_MEKK1                   WLK---GQ-QIGLGAFSSCYQAQDVG-TGTLMAVKQVTYVRNT--------S--------
nsy-1_Cele_ASK                      SNE---RV-VLGKGTYGTVYAARDMD-TQRQIVVKEIEVKY-------------------
B0414.7_Cele_MEKK4                  WAL---LD-HIASGSFGSVHRAMDID-SHRVIAAKVMRIQRE------------------
STE11_Scer_STE11-Unclassified       WLK---GA-CIGSGSFGSVYLGMNAH-TGELMAVKQVEIKNNN--------IGVPTDNNK
SSK22_Scer_STE11-Unclassified       WQK---RS-FIGGGTFGQVYSAINLE-NGEILAVKEIKIHDTT--------T--------
SSK2_Scer_STE11-Unclassified        WQK---RN-FIGGGTFGRVYSAVDLD-NGEILAVKEINIQDSK--------S--------
CDC15_Scer_CDC15                    YHL---KQ-VIGRGSYGVVYKAINKH-TDQVVAIKEVVYEND------------------
BCK1_Scer_STE11-Unclassified        WMK---GE-MIGKGSFGAVYLCLNVT-TGEMMAVKQVEVPKYS--------SQ-------
Pk92B_Dmel_ASK                      QNR---KM-VLGKGTYGTVYAARDKQ-TQVRIAIKEVPEKN-------------------
Mekk1_Dmel_MEKK4                    WHR---GI-KIGQGRFGKVYTAVNNN-TGELMAMKEIAIQPGE-----------------
DDB0229877_Ddis_CDC15               YQI---GE-AVGKGAFGKVFKALNAE-TGDFCAIKQIEKTII------------------
DDB0229896_Ddis_CDC15               YNL---GV-VIGKGGFGTVYQGLDIE-DGDFVAIKQINLTKI------------------
DDB0229915_Ddis_CDC15               YTL---GE-KIGRGAFGQVFKGLNGK-TGEFVAIKQIDSNKI------------------
DDB0229971_Ddis_CDC15               FVI---SDIAIGKGAFATVFKGLNTL-SGDFVAIKRFEKSKI------------------
DDB0231212_Ddis_CDC15               YLL---ID-IIGKGGFGVVYKGLHKT-KGYFSAIKKIKIMKKK--------K--------
MEKKalpha_Ddis_STE11-Unclassified   WQK---GQ-ILGRGGYGSVYLGLNKD-TGELFAVKQLEIVDIN--------S--------
11359_Tthe_STE11-Unclassified       FKK---GH-IIDRGSYGEVYQCLEVN-TGQLYAIKTIRKNKDK--------A--------
15684_Tthe_STE11-Unclassified       ------DK-ILGKGTFGTVVLGHNKN-TGEIVAVKLIETQYDR-----------------
18758_Tthe_STE11-Unclassified       WKS---GD-FIGAGSFGQVFTAMNCN-TGEIFVVKKIMVHGQS--------K--------
23105_Tthe_STE11-Unclassified       VEL---RE-LLGEGAYGKVYKGFIKK-TGKFIAVKQLKLGLKD--------N--------
29763_Tthe_STE11-Unclassified       WQS---GE-VLGTGSFGQVILGMNID-TGEFMAVKQVHIGGYN--------Q--------
4322_Tthe_CDC15                     YKV---GV-KLGQGASGTVYKGEHIE-TGQVVAIKLVSTVNI------------------
6622_Tthe_STE11-Unclassified        AQV---GE-LIGQGAYGRVYKGFVKS-TGKFIAIKEMKEEMML--------G--------
7147_Tthe_STE11-Unclassified        YKK---CE-LIDKGAYGKVYKGIDTI-TNQVVAIKYIEITGTF--------E--------
MEKK1_Spur_MEKK1                    WTK---GA-ILGTGAFSSCYMARDVK-TGTLMAVKQISFCRNN--------A--------
MEKK2_Spur_MEKK2                    WQR---GK-LLGQGAFGVVYVCYDAD-TGRELAVKQVPTENSN--------T--------
MEKK4_Spur_MEKK4                    WQR---GF-KIGEGQFGTVYSCINMN-TGETLAVKEMRFQRND-----------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  WKK---GN-LLGKGAFGTVYCGLT-N-TGQLLAVKQVELSEID--------K--------
CC1G_00852_Ccin_CDC15               --L---GN-CIGRGQFGSVYRALNLN-TGQMVAVKRIRLEGLK-----------------
CC1G_05008_Ccin_CDC15               YQL---GD-SLGKGAFGQVYRALNWE-TGETVAVKEIQLSNI------------------
CC1G_12014_Ccin_STE11-Unclassified  WIK---GA-LIGAGSFGKVYLGMDAS-NGLLMAVKQVELPQGD--------GP-------
CC1G_10524_Ccin_STE11-Unclassified  WIR---GE-LLGKGSYGRVYLALNAT-TGEVMAVKQVELPKTP--------SD-------
CC1G_13687_Ccin_STE11-Unclassified  WQQ---GR-FIGAGAFGSVYLAMNLD-SGSLMAVKEIKFQELS--------G--------
CC1G_10513_Ccin_STE11-Unclassified  WVR---GE-LIGKGTYGRVYLALNAT-TGEMIAVKQVELPQTP--------SD-------
AqueK224_Aque_ASK                   LHE---PV-VLGKGSFGIVYSAIDLV-TKKKMAIKEIPERT-------------------
AqueK225_Aque_MEKK1                 ----------------------------------KQIRLEQES--------L--------
AqueK226_Aque_MEKK15                WKK---GK-LLGRGAYGKVYEGLL-D-TARLIAVKEVELEVED--------N--------
AqueK227_Aque_MEKK2                 WSK---GR-LLGTGAFGQVFLCTDLD-TQMDMAVKVVDIDHIENIKPSLDSL--------
AqueK228_Aque_MEKK4                 WRR---GR-KLGEGQFGVVYECINLD-RGEVQAVKMISLKEKS-----------------
MEKK2-p1_a_Smoe_MEKK2-plant1        WRK---GE-LIGVGAYGRVYMGMNLD-SGELIAVKQVLIAASN--------F--------
MEKK2-p1_b_Smoe_MEKK2-plant1        WRK---GE-LIGVGAYGRVYMGMNLD-SGELIAVKQVLIAASN--------F--------
STE11-p2_b-2_Smoe_MEKK2-plant2      WTR---GE-LLGEGAYGKVFAGLNQT-TGELMAVKQLKIEPTD--------G--------
STE11-p2_a_Smoe_MEKK2-plant2        ---------------FSQVFSGLNQS-TGELMAVKQLKIDPGE--------G--------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------VFAGLNQT-TGELMAVKQLKIEPTD--------G--------
STE11-p2_h_Smoe_MEKK2-plant2        -------------------------------MAVKQLKIDPGE--------G--------
NPK1-2_Smoe_NPK1                    YII---GD-EIGKGAYGRVYKGLDLE-NGDFVAIKQVSLENI------------------
NPK1-1_Smoe_NPK1                    YII---GD-EIGKGAYGRVYKGLDLE-NGDFVAIKQVSLENI------------------
STE11-p2_e-2_Smoe_STE11-plant1      WKK---LE-LLGSGSFGSVYRAVG-SD-GNYFAVKEVPLSNAN-----------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      WKK---LE-LLGSGSFGSVYRAVG-SD-GNYFAVKEVPLSNAN-----------------
STE11-p2_g_Smoe_STE11-plant2        -------------------------N-IGRMCAMKEVRIIGDN--------D--------
STE11-p2_c_Smoe_STE11-plant2        WKK---GA-LIGSGSFGNVYVGFDSY-IGRFCAIKEAMISCSD--------Y--------
STE11-p2_f_Smoe_STE11-plant2        WQK---GN-LLGVGSFGRVYKGFS-D-SGTFCAMKEVLVVDD---------P--------
STE11-p2_d-1_Smoe_STE11-plant2      WQK---GK-LIGRGSFGNVYVGFDSENVGRMCAMKEVPLLSDD--------S--------
STE11-p2_d-2_Smoe_STE11-plant2      -------------------------------CAMKEVPLLSDD--------S--------
STE11-p3-1_Smoe_STE11-plant3        WVC---GG-LIGAGAFGSVNLAVDNE-TGDLFAVKSTECSGGR-----------------
STE11-p3-2_Smoe_STE11-plant3        WVC---GG-LIGAGAFGSVNLAVDNE-TGDLFAVKSTECSGGR-----------------
GK076_Glam_CDC15                    -----------------RTYKALCNI-DGIVPAIKIYRLSDVS-----------------
GK077_Glam_CDC15                    YTL---HC-LIGKGAFAKVWKAADEV-TGGFVALKQLEPKGKK--------K--------
GK078_Glam_STE11-Unclassified       YSL---GR-IIGHGSFGQVYLALEHL-TGKLLAVKEMVVKNCS-----------------


MEKK15_Hsap_MEKK15                  ------------------------------L----AAEKEYRKLQEEVDL-LKALKH-VN
MAP3K7_Hsap_ASK                     -------------------------------------SRYSQPLHEEIAL-HKYLKH-RN
MAP3K6_Hsap_ASK                     -------------------------------------SRFSQPLHEEIAL-HRRLRH-KN
MAP3K5_Hsap_ASK                     -------------------------------------SRYSQPLHEEIAL-HKHLKH-KN
MAP3K4_Hsap_MEKK4                   -------------------------------------HKTIKETADELKI-FEGIKH-PN
MAP3K3_Hsap_MEKK2                   -----------------------------------ETSKEVSALECEIQL-LKNLQH-ER
MAP3K2_Hsap_MEKK2                   -----------------------------------ETSKEVNALECEIQL-LKNLLH-ER
MAP3K1_Hsap_MEKK1                   ------------------------------S----EQEEVVEALREEIRM-MSHLNH-PN
MEKK15_Mmus_MEKK15                  ------------------------------L----ATEKEYRKLQEEVDL-LKALKH-VN
MAP3K7_Mmus_ASK                     -------------------------------------IRYSQPLHEEIAL-HKYLKH-RN
MAP3K6_Mmus_ASK                     -------------------------------------SRFSQPLHEEIAL-HKRLRH-KN
MAP3K5_Mmus_ASK                     -------------------------------------SRYSQPLHEEIAL-HKHLKH-KN
MAP3K4_Mmus_MEKK4                   -------------------------------------HKTIKETADELKI-FEGIKH-PN
MAP3K3_Mmus_MEKK2                   -----------------------------------ETSKEVSALECEIQL-LKNLQH-ER
MAP3K2_Mmus_MEKK2                   -----------------------------------ETSKEVNALECEIQL-LKNLLH-ER
MAP3K1_Mmus_MEKK1                   ------------------------------S----EQEEVVEALREEIRM-MGHLNH-PN
nsy-1_Cele_ASK                      -------------------------------------DEEVQPLMEEISL-HSTLCH-AN
B0414.7_Cele_MEKK4                  ---------------------------------------NHKAIESEINI-FRQLIH-EN
STE11_Scer_STE11-Unclassified       QANSDENNEQEEQQEKIEDVGAVSHPKTNQN----IHRKMVDALQHEMNL-LKELHH-EN
SSK22_Scer_STE11-Unclassified       ------------------------------------MKKIFPLIKEEMTV-LEMLNH-PN
SSK2_Scer_STE11-Unclassified        ------------------------------------MQKIFPLIKEEMSV-LEILNH-PN
CDC15_Scer_CDC15                    --------------------------------------EELNDIMAEISL-LKNLNH-NN
BCK1_Scer_STE11-Unclassified        ---------N--------------------E----AILSTVEALRSEVST-LKDLDH-LN
Pk92B_Dmel_ASK                      -------------------------------------SQDVQPLHEEIKL-HSQLRH-RN
Mekk1_Dmel_MEKK4                    -------------------------------------TRALKNVAEELKI-LEGIKH-KN
DDB0229877_Ddis_CDC15               ------------------------------------SEKQLPSIIQEIKL-LQTLQH-PN
DDB0229896_Ddis_CDC15               ------------------------------------PKDQLQGIMNEIDL-LKNLNH-AN
DDB0229915_Ddis_CDC15               ------------------------------------DESSLQSVKGEVEI-LHKLRH-NN
DDB0229971_Ddis_CDC15               ------------------------------------SNEQHSSVSTEFDI-LQRLNH-EN
DDB0231212_Ddis_CDC15               ------------------------------L-----QSESQISLMAEINL-LKVLSH-HN
MEKKalpha_Ddis_STE11-Unclassified   -----------------------------DP----KLKNMILSFSKEIEV-MRSLRH-DN
11359_Tthe_STE11-Unclassified       -----------------------------------VLEKEVQSLAKEIKE-YKKLSH-KN
15684_Tthe_STE11-Unclassified       -------------------------------------KQKYKSIIDEVKI-LKQMRH-KN
18758_Tthe_STE11-Unclassified       -----------------------------------LDKEFLDEQEKELRI-MQTLSH-KH
23105_Tthe_STE11-Unclassified       ------------------------------N----KLQEKLEQYLQEIAL-LNHLEH-PN
29763_Tthe_STE11-Unclassified       ------------------------------K----DRQEKIQQIQSEIEA-LRNFSD-KN
4322_Tthe_CDC15                     ------------------------------------KKENIKSIKKEMHL-LKKLKH-EN
6622_Tthe_STE11-Unclassified        ------------------------------E----DAHSLLESICKEIQL-LKQLSH-KN
7147_Tthe_STE11-Unclassified        -----------------------------------EVKKEINSLKKEIVL-LKKLNH-QN
MEKK1_Spur_MEKK1                    ------------------------------G----DQEDTMEEIKKEIKL-MATFDH-PH
MEKK2_Spur_MEKK2                    -----------------------------------DARKEVQSLKQEIEL-LRNLQH-PR
MEKK4_Spur_MEKK4                    -------------------------------------HQVIRDIADEIKN-LEGIRH-PN
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------E----KAKQQYLKLQEEVQL-LKTLRH-KN
CC1G_00852_Ccin_CDC15               -------------------------------------EEEVTQLMREVDL-VKSLSH-PS
CC1G_05008_Ccin_CDC15               ------------------------------------PKGELPEIMSEIDL-LKNLNH-EN
CC1G_12014_Ccin_STE11-Unclassified  ----------------------------SQE----RKKSMLSALEREIEL-LKVLQH-EN
CC1G_10524_Ccin_STE11-Unclassified  ---------K------------------MKP----QQLDVMKALKFEGDT-LKDLDH-PN
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------LPNLYAQIKDELSV-MEMLHH-PN
CC1G_10513_Ccin_STE11-Unclassified  ---------R------------------NDS----RQNTVVQALKLESET-LKDLDH-PH
AqueK224_Aque_ASK                   -------------------------------------EGQFQSLEEEIQL-HRHLQH-EN
AqueK225_Aque_MEKK1                 ------------------------------T----AVNETL--ISLRLSS-SSKDH-PPN
AqueK226_Aque_MEKK15                ------------------------------E----KALVQFKKIQLEVDI-LRSLSH-KN
AqueK227_Aque_MEKK2                 -----------------------------------KMSKEVRSFETEVQL-LKNIHH-ER
AqueK228_Aque_MEKK4                 -------------------------------------HNTVRDILSEVGV-FQSINH-KN
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------AKGKAQLSAHIRELEEEVKL-LQNLSH-PN
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------AKGKAQLSAHIRELEEEVKL-LQNLSH-PN
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------Q----SRAVYLASLEREIDL-YKQLRH-RH
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------Q----EKSFYLAALEREINL-YRKLRH-KH
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------Q----SRAVYLASLEREIDL-YKQLRH-RH
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------Q----EKSFYLAALEREINL-YRKLRH-KH
NPK1-2_Smoe_NPK1                    ------------------------------------PPEDLASIMQEIDL-LKNLNH-KN
NPK1-1_Smoe_NPK1                    ------------------------------------PPEDLASIMQEIDL-LKNLNH-KN
STE11-p2_e-2_Smoe_STE11-plant1      -------------------------------------DQSGLQLQQEVNL-LGNLRH-EN
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      -------------------------------------DQSGLQLQQEVNL-LGHLRH-EN
STE11-p2_g_Smoe_STE11-plant2        -----------------------------------QSKESAKQLGQEITL-LSRLRH-QN
STE11-p2_c_Smoe_STE11-plant2        -----------------------------------RSQECCKQLRQEIAM-LSRLRH-PN
STE11-p2_f_Smoe_STE11-plant2        -----------------------------------KSIESVKQLMQEINM-LSSLRH-PN
STE11-p2_d-1_Smoe_STE11-plant2      -----------------------------------KSKESVKQLSQEIAT-LSRLRH-TN
STE11-p2_d-2_Smoe_STE11-plant2      -----------------------------------KSKESVKQLSQEIAT-LSRLRH-TN
STE11-p3-1_Smoe_STE11-plant3        -----------------------------------SSDGALLALENELSI-LQSLQSSPR
STE11-p3-2_Smoe_STE11-plant3        -----------------------------------SSDGALLALENELSI-LQSLQSSPR
GK076_Glam_CDC15                    -------------------------------------KSSVDFDQKEIDTAARSLLQ-PN
GK077_Glam_CDC15                    ------------------------------A----VDQGFIKEVMSEINL-LSKLNH-SN
GK078_Glam_STE11-Unclassified       -------------------------------------REVLEAIDAETRI-LINLRH-PN


MEKK15_Hsap_MEKK15                  IVAYLGTCLQ------ENTVSIFMEFVPGGSIS----------------SIIN--RF-GP
MAP3K7_Hsap_ASK                     IVQYLGSVS------ENGYIKIFMEQVPGGSLS----------------ALLR-SKW-GP
MAP3K6_Hsap_ASK                     IVRYLGSAS------QGGYLKIFMEEVPGGSLS----------------SLLR-SVW-GP
MAP3K5_Hsap_ASK                     IVQYLGSFS------ENGFIKIFMEQVPGGSLS----------------ALLR-SKW-GP
MAP3K4_Hsap_MEKK4                   LVRYFGVELH------REEMYIFMEYCDEGTLE----------------EVS---RL-G-
MAP3K3_Hsap_MEKK2                   IVQYYGCLRD----RAEKTLTIFMEYMPGGSVK----------------DQLK--AY-GA
MAP3K2_Hsap_MEKK2                   IVQYYGCLRD----PQEKTLSIFMEYMPGGSIK----------------DQLK--AY-GA
MAP3K1_Hsap_MEKK1                   IIRMLGATCE----K--SNYNLFIEWMAGGSVA----------------HLLS--KY-GA
MEKK15_Mmus_MEKK15                  IVAYLGTCLE------ENTLSIFMEFVPGGSIS----------------SIIN--RF-GP
MAP3K7_Mmus_ASK                     IVQYLGSVS------ENGYIKIFMEQVPGGSLS----------------ALLR-SKW-GP
MAP3K6_Mmus_ASK                     IVRYLGSAS------QGGYLKIFMEEVPGGSLS----------------SLLR-SVW-GP
MAP3K5_Mmus_ASK                     IVQYLGSFS------ENGFIKIFMEQVPGGSLS----------------ALLR-SKW-GP
MAP3K4_Mmus_MEKK4                   LVRYFGVELH------REEMYIFMEYCDEGTLE----------------EVS---RL-G-
MAP3K3_Mmus_MEKK2                   IVQYYGCLRD----RAEKILTIFMEYMPGGSVK----------------DQLK--AY-GA
MAP3K2_Mmus_MEKK2                   IVQYYGCLRD----PQEKTLSIFMEYMPGGSIK----------------DQLK--AY-GA
MAP3K1_Mmus_MEKK1                   IIRMLGATCE----K--SNYNLFIEWMAGGSVA----------------HLLS--KY-GA
nsy-1_Cele_ASK                      IVQYLGCDLVG-KDGSNDHFLIFMEHVPGGSLS----------------SLLR-SKW-GP
B0414.7_Cele_MEKK4                  LVKYYGVQVE------DSDVIIFMEYCSQGTLE----------------RIC----H-GK
STE11_Scer_STE11-Unclassified       IVTYYGASQE------GGNLNIFLEYVPGGSVS----------------SMLN--NY-GP
SSK22_Scer_STE11-Unclassified       IVQYYGVEVH------RDKVNIFMEYCEGGSLA----------------SLLD--HG-RI
SSK2_Scer_STE11-Unclassified        IVSYYGVEVH------RDKVNIFMEYCEGGSLA----------------ALLE--HG-RI
CDC15_Scer_CDC15                    IVKYHGFIRK------SYELYILLEYCANGSLR----------------RLIS--RSSTG
BCK1_Scer_STE11-Unclassified        IVQYLGFENK------NNIYSLFLEYVAGGSVG----------------SLIR--MY-GR
Pk92B_Dmel_ASK                      IVRYLGSCS------ENGFFKIFMEQVPGGSLS----------------DLLE-TKW-GP
Mekk1_Dmel_MEKK4                    LVRYYGIEVH------REELLIFMELCSEGTLE----------------SLVE--LT-GN
DDB0229877_Ddis_CDC15               IVKFIESYET------SRYLYFALEFIEGGSLA----------------KIAK--RY-GC
DDB0229896_Ddis_CDC15               IVKYIKYVKT------KDNLYIVLEYVENGSLS----------------GIIK--KF-GK
DDB0229915_Ddis_CDC15               IVKVLGVVEV------QAQLNFILEYVENGSLR----------------DVIE--KF-GP
DDB0229971_Ddis_CDC15               IVRILGREEN------ENYIYIFLEYMENGSLS----------------TILN--NF-GT
DDB0231212_Ddis_CDC15               IVRYYEHIPS------SSHSYIVMEFIENGSLE----------------KIIK--RH-GL
MEKKalpha_Ddis_STE11-Unclassified   IVRYLGTSLD------QSFLSVFLEYIPGGSIS----------------SLLG--KF-GA
11359_Tthe_STE11-Unclassified       IVKYIDTELD----EDEKGINIILEYVSGGSIR----------------QMLD--KF-GK
15684_Tthe_STE11-Unclassified       IVRYYGIQEH----KAKDHIGIVCEYVSGGSLW----------------RLIQ--KF-GK
18758_Tthe_STE11-Unclassified       IIQYKGHERQ------QDCLCIFLEYMSEGNID----------------QMLK--KF-GP
23105_Tthe_STE11-Unclassified       IVKYYDCKHE----E--DNILIYMEQMPGGSLS----------------SMLE--KF-GR
29763_Tthe_STE11-Unclassified       IVRYIGIKKS----E--TSINIFLEYVPGGSIS----------------SLLY--RY-GK
4322_Tthe_CDC15                     IVTYIDFIQT------ENHYAIILEYIESGSLY----------------GIIK--KF-GP
6622_Tthe_STE11-Unclassified        IVNYIGSKKQ----E--GSVYIYMEYMPGGSIS----------------EMLK--KY-GG
7147_Tthe_STE11-Unclassified        IVKYYDFEIS----DDKSGVDIILEYVPNGSLR----------------MALN--KQ-RC
MEKK1_Spur_MEKK1                    IVRLMGATQH----D--AHFNVFVEWMPGGAVS----------------TLLK--DF-GA
MEKK2_Spur_MEKK2                    IVQYFGCLEE------NGTLSIFMEFMSGGSVK----------------DELR--LY-GP
MEKK4_Spur_MEKK4                    LVRYYGVEIH------RFKMYHFLQYLTRTTLK----------------FVC---HL-G-
ASK_Spur_ASK                        -----------------------MEQVPGGSLS----------------ALLR-SKW-GP
MEKK15_Spur_MEKK15                  IVGFLGVSLE------DNVVNIFMQFIPGGSIA----------------SLLA--RF-GS
CC1G_00852_Ccin_CDC15               IVKYEGMARD------EDTLSIVLEYAENGSLG----------------QTLK--AF-GK
CC1G_05008_Ccin_CDC15               IVKYKGFVKT------REFLYIILEFCENGSLH----------------NIIK--KF-GK
CC1G_12014_Ccin_STE11-Unclassified  IVQYLYSSSD------DEYLNIFLEYVPGGSVA----------------TLLS--NY-GA
CC1G_10524_Ccin_STE11-Unclassified  IVSYLGFEES------QDYLSIFLEYVPGGTVG----------------SLLV--KN-GR
CC1G_13687_Ccin_STE11-Unclassified  VVEYYGIEVH------RDKVYIFEEYCQGGSLA----------------ALLE--HG-RI
CC1G_10513_Ccin_STE11-Unclassified  IVQYLGFEET------PANLSIFLEYVPGGSIG----------------SCLH--KH-GK
AqueK224_Aque_ASK                   IVQYFGAYS------DGGIFRIFMEQVPGGSLS----------------HLLK-FTW-GP
AqueK225_Aque_MEKK1                 IVEFYGASLLP--LQVETKLQLFLELMPC-CLQ----------------SYLY--NG-GP
AqueK226_Aque_MEKK15                IVQYLGTSIN------ETIVYIFMEYITGGSLQ----------------SILK--RF-GS
AqueK227_Aque_MEKK2                 VVGYYGTERR------EGKLFIFMEYLAGGSIY----------------QHLK--NT-GA
AqueK228_Aque_MEKK4                 IVHFHGVEIH------DTDLYLFMEYCNQGTLW----------------GAAK---Q-G-
MEKK2-p1_a_Smoe_MEKK2-plant1        IVRYLGTARE----E--EALNIFLEFVPGGSIS----------------SLLG--KF-GS
MEKK2-p1_b_Smoe_MEKK2-plant1        IVRYLGTARE----E--EALNIFLEFVPGGSIS----------------SLLG--KF-GS
STE11-p2_b-2_Smoe_MEKK2-plant2      IVGYIAMEQD----EANNLLYIFLEYVSGGSIQ----------------SMLE--RF-GR
STE11-p2_a_Smoe_MEKK2-plant2        IVGYINMEQD----EQSGSLYIFLEYVSGGSIQRQAAYFNFSYHLLLLNSMLE--RF-GR
STE11-p2_b-1_Smoe_MEKK2-plant2      IVGYIAMEQD----EANNLLYIFLEYVSGGSIQ----------------SMLE--RF-GR
STE11-p2_h_Smoe_MEKK2-plant2        IVGYINMEQD----EQSGSLYIFLEYVSGGSIQRQAAYFIFSYHLFLLNSMLE--RF-GR
NPK1-2_Smoe_NPK1                    IVKYRGSIKT------KTHLYIILEYVENGSLA----------------SIVKPNKF-GA
NPK1-1_Smoe_NPK1                    IVKYRGSIKT------KTHLYIILEYVENGSLA----------------SIVKPNKF-GA
STE11-p2_e-2_Smoe_STE11-plant1      IVQYLGTQKT------KDKLYIFLELVTQGSIV----------------SQYK--HF-EM
STE11-p2_j_Smoe_STE11-plant1        ---------------------------MKCSLA----------------SVIK--ES-NG
STE11-p2_e-1_Smoe_STE11-plant1      IVQYLGTQKT------NDKLYIFLELVTQGSIV----------------SQYK--HF-EM
STE11-p2_g_Smoe_STE11-plant2        IVQYYGSEAV------EDNLYIYLEYVSGGSIH----------------KLLQ--DY-GP
STE11-p2_c_Smoe_STE11-plant2        IVQYYGSESM------KDRLHIYLEFASGGSIQ----------------KLLH--EY-GA
STE11-p2_f_Smoe_STE11-plant2        IVQYLGSEML------DDSLYIYLEFVSGGSIH----------------KVLQ--EY-GA
STE11-p2_d-1_Smoe_STE11-plant2      IVQYYGSETM------EDGLYIYLEYVSGGSIH----------------KLLQ--EY-GA
STE11-p2_d-2_Smoe_STE11-plant2      IVQYYGSETM------EDGLYIYLEYVSGGSIH----------------KLLQ--EY-GA
STE11-p3-1_Smoe_STE11-plant3        IVKCLGSAWSSSAESGQPVRSVFLEYMPGGSIA----------------DLMA-KLG-GK
STE11-p3-2_Smoe_STE11-plant3        IVKCLGSAWSSSAESGQPVRSVFLEYMPGGSIA----------------DLMA-KLG-GK
GK076_Glam_CDC15                    LVKYIEAFAD------KEYFYVVMEFVPN-SLD----------------QIIA--H--QR
GK077_Glam_CDC15                    IVKYRGCFLE------QNYLYIILELVDFGSLQ----------------TLIK--QY-DD
GK078_Glam_STE11-Unclassified       IVNIYDIEVS----DDGNKLLIVMDFIAGGSLA----------------SLSK--SF-KG
                                                                   :

MEKK15_Hsap_MEKK15                  LP--EMVFCKYT--------KQILQGVAYLHEN-CVVH-RDIK---------GNNVM-LM
MAP3K7_Hsap_ASK                     MK--EPTIKFYT--------KQILEGLKYLHEN-QIVH-RDIK---------GDNVL-VN
MAP3K6_Hsap_ASK                     LKDNESTISFYT--------RQILQGLGYLHDN-HIVH-RDIK---------GDNVL-IN
MAP3K5_Hsap_ASK                     LKDNEQTIGFYT--------KQILEGLKYLHDN-QIVH-RDIK---------GDNVL-IN
MAP3K4_Hsap_MEKK4                   LQ--EHVIRLYS--------KQITIAINVLHEH-GIVH-RDIK---------GANIF-LT
MAP3K3_Hsap_MEKK2                   LT--ESVTRKYT--------RQILEGMSYLHSN-MIVH-RDIK---------GANIL-RD
MAP3K2_Hsap_MEKK2                   LT--ENVTRKYT--------RQILEGVHYLHSN-MIVH-RDIK---------GANIL-RD
MAP3K1_Hsap_MEKK1                   FK--ESVVINYT--------EQLLRGLSYLHEN-QIIH-RDVK---------GANLL-ID
MEKK15_Mmus_MEKK15                  LP--EMVFCKYT--------RQILQGVAYLHDN-CVVH-RDIK---------GNNVM-LM
MAP3K7_Mmus_ASK                     MK--EPTIKFYT--------KQILEGLKYLHEN-QIVH-RDIK---------GDNVL-VN
MAP3K6_Mmus_ASK                     LKDNESTISFYT--------RQILQGLSYLHEN-RIVH-RDIK---------GDNVL-IN
MAP3K5_Mmus_ASK                     LKDNEQTIGFYT--------KQILEGLKYLHDN-QIVH-RDIK---------GDNVL-IN
MAP3K4_Mmus_MEKK4                   LQ--EHVIRLYT--------KQITVAINVLHEH-GIVH-RDIK---------GANIF-LT
MAP3K3_Mmus_MEKK2                   LT--ESVTRKYT--------RQILEGMSYLHSN-MIVH-RDIK---------GANIL-RD
MAP3K2_Mmus_MEKK2                   LT--ENVTRKYT--------RQILEGVHYLHSN-MIVH-RDIK---------GANIL-RD
MAP3K1_Mmus_MEKK1                   FK--ESVVINYT--------EQLLRGLSYLHEN-QIIH-RDVK---------GANLL-ID
nsy-1_Cele_ASK                      MN--ENAMNYYG--------KQILEGLKYLHEL-KIVH-RDIK---------GDNVL-VN
B0414.7_Cele_MEKK4                  MD--LKMVRQYT--------NSLLRAVQYLHSH-KIIH-RDIK---------PANIF-LD
STE11_Scer_STE11-Unclassified       FE--ESLITNFT--------RQILIGVAYLHKK-NIIH-RDIK---------GANIL-ID
SSK22_Scer_STE11-Unclassified       ED--EMVTQVYT--------FELLEGLAYLHQS-GVVH-RDIK---------PENIL-LD
SSK2_Scer_STE11-Unclassified        ED--EMVTQVYT--------LQLLEGLAYLHES-GIVH-RDVK---------PENIL-LD
CDC15_Scer_CDC15                    LS--ENESKTYV--------TQTLLGLKYLHGE-GVIH-RDIK---------AANIL-LS
BCK1_Scer_STE11-Unclassified        FD--EPLIKHLT--------TQVLKGLAYLHSK-GILH-RDMK---------ADNLL-LD
Pk92B_Dmel_ASK                      LKDNESTMAFYS--------KQILEGLKYLHEQ-DIVH-RDIK---------GDNVL-VN
Mekk1_Dmel_MEKK4                    LP--EALTRRFT--------AQLLSGVSELHKH-GIVH-RDIK---------TANIFLVD
DDB0229877_Ddis_CDC15               FQ--EPLLSRYF--------SQVLKGLAYLHEK-GVIH-RDIK---------SDNIL-IT
DDB0229896_Ddis_CDC15               FP--ETLVCVYI--------RQVLEGLVYLHEQ-GVVH-RDIK---------GANIL-TT
DDB0229915_Ddis_CDC15               LS--EELCIIYL--------YQMLQGLAYLHSN-KVIH-RDIK---------ASNIL-IT
DDB0229971_Ddis_CDC15               FP--ESLICNYV--------ENVLKGLVYLHQE-GVIH-RDIK---------AANIL-IN
DDB0231212_Ddis_CDC15               LP--ESLVTVYI--------AQVLNGLEYLHRQ-GVIH-RDIK---------AANLL-IS
MEKKalpha_Ddis_STE11-Unclassified   FS--ENVIKVYT--------KQILQGLSFLHAN-SIIH-RDIK---------GANIL-ID
11359_Tthe_STE11-Unclassified       FN--EKVISIYT--------NQVLQGLKYLHSN-HVFH-RDIK---------GGNIL-ID
15684_Tthe_STE11-Unclassified       FS--EPLIRKYT--------TDILYGLQYLHYH-GITH-RDIK---------GANIL-VD
18758_Tthe_STE11-Unclassified       LE--EQTIKVYA--------RQILSGIQYLHSQ-KVIH-KDIK---------GANIL-VG
23105_Tthe_STE11-Unclassified       FE--EALIKKFV--------KQIISGLAYLHSQ-GIVH-RDIKLTYINKILQGANIL-TD
29763_Tthe_STE11-Unclassified       FN--ETLIRKFT--------QQILKGLEYLHAH-EIIH-RDIK---------GANVL-VD
4322_Tthe_CDC15                     FQ--ESLVIIFI--------KQVLRGLEYLHRQ-GIVH-RDIK---------GANIL-TT
6622_Tthe_STE11-Unclassified        FD--EEVIQKFV--------KQLLEGLIYLHSK-GVIH-RDLK---------GANIL-SD
7147_Tthe_STE11-Unclassified        FD--ETKAAIYT--------KQVLEGLDYLHKN-NIIH-RDLK---------GANLL-LD
MEKK1_Spur_MEKK1                    FS--NAVTVKYI--------HQVCLGLAYLHDN-RVIH-RDLK---------GANLL-MD
MEKK2_Spur_MEKK2                    LT--DTVTRKYT--------RQILEGTAYLHDH-HIVH-RDIK---------GANVL-R-
MEKK4_Spur_MEKK4                    LQ--EHEIS--------------------------LII-KNMN---------DLNQ----
ASK_Spur_ASK                        LKDHEDTIIYYT--------KQILEGLRYLHDQ-KIVH-RDIK---------GDNVL-VN
MEKK15_Spur_MEKK15                  LD--ETVFCRYT--------KQILEGTQYLHEN-NVIH-RDIK---------GANIM-LM
CC1G_00852_Ccin_CDC15               LN--ERLVASYV--------VKILEGLHYLHTS-DVVH-CDLK---------AANIL-TT
CC1G_05008_Ccin_CDC15               FP--ENLVAVYI--------SQVLEGLVYLHDQ-GVIH-RDIK---------GANIL-TN
CC1G_12014_Ccin_STE11-Unclassified  FE--EPLVRNFV--------RQILQGLSYLHER-DIIH-RDIK---------GANIL-VD
CC1G_10524_Ccin_STE11-Unclassified  LR--EEVTKSWL--------RQILQGLDYLHGK-GILH-RDLK---------ADNIL-VD
CC1G_13687_Ccin_STE11-Unclassified  ED--ERILQLYT--------VQMLDGLSYLHSQ-GIVH-RDIK---------PDNIL-LD
CC1G_10513_Ccin_STE11-Unclassified  FS--ENVTKSFT--------GQILSGLEYLHSK-GILH-RDLK---------ADNIL-VE
AqueK224_Aque_ASK                   LINDEGTIRHYT--------RQILKGLGYLHNQ-KIVH-RDIK---------GDNVL-VN
AqueK225_Aque_MEKK1                 LS--VEDAHNYA--------CQLFDALDYLHGKINLVH-SDIK---------PGNLL-ID
AqueK226_Aque_MEKK15                LN--EKTIVRYV--------RQMGRGLNYLHNN-GVIH-RDIK---------GANVM-VS
AqueK227_Aque_MEKK2                 LS--EALTRKYT--------RQILEGVAFLHGM-KIVH-RDIK---------GANIL-RD
AqueK228_Aque_MEKK4                 LE--ERMIRLYT--------RDLLRAVDVLHDR-GIVH-RDIK---------GANIF-LS
MEKK2-p1_a_Smoe_MEKK2-plant1        FT--EPVIRMYT--------RQLLLGLEYLHQN-KIMH-RDIK---------GANIL-VD
MEKK2-p1_b_Smoe_MEKK2-plant1        FT--EPVIRMYT--------RQLLLGLEYLHQN-KIMH-RDIK---------GANIL-VD
STE11-p2_b-2_Smoe_MEKK2-plant2      FS--ESLVRIYT--------RQLLLGLEYLHAN-KIVH-RDIK---------GGNVL-VD
STE11-p2_a_Smoe_MEKK2-plant2        FS--EPLVRVYT--------RQLLLGLQYLHEN-RIVH-RDIK---------GGNVL-VD
STE11-p2_b-1_Smoe_MEKK2-plant2      FS--ESLVRIYT--------RQLLLGLEYLHAN-KIVH-RDIK---------GGNVL-VD
STE11-p2_h_Smoe_MEKK2-plant2        FS--EPLVRVYT--------RQLLLGLQYLHEN-RIVH-RDIK---------GGNVL-VD
NPK1-2_Smoe_NPK1                    FP--ESLVAVYIAQALLTRYSQVLEGLAYLHEQ-GVIH-RDIK---------GANIL-TT
NPK1-1_Smoe_NPK1                    FP--ESLV-------------AVLEGLAYLHEQ-GVIH-RDIK---------GANIL-TT
STE11-p2_e-2_Smoe_STE11-plant1      FD--EQ-IRKYT--------KQILSGLKYLHEK-KVVH-RDIK---------CANIL-VH
STE11-p2_j_Smoe_STE11-plant1        LD--ESKLRVYT--------RQILSGLEYLHRM-NIVHSRDVK---------CGNIL-LD
STE11-p2_e-1_Smoe_STE11-plant1      FD--EQ-IRKYT--------KQILSGLKYLHEK-KVVH-RDIK---------CANIL-VH
STE11-p2_g_Smoe_STE11-plant2        FK--ESVIRRYT--------RQILSGLSFLHSV-ETVH-RDIK---------GANIL-VD
STE11-p2_c_Smoe_STE11-plant2        FE--EPVIKSYA--------RQIVCGLAYLHSK-QTVH-RDIK---------GANVL-ID
STE11-p2_f_Smoe_STE11-plant2        FK--EPVIRSYT--------QQILSGLQYLHSM-NKVH-RDIK---------GANIL-VD
STE11-p2_d-1_Smoe_STE11-plant2      FK--EPVIRSYT--------RQILSGLAYLHST-STVH-RDIK---------GANIL-VD
STE11-p2_d-2_Smoe_STE11-plant2      FK--EPVIRSYT--------RQILSGLAYLHST-STVH-RDIK---------GANIL-VD
STE11-p3-1_Smoe_STE11-plant3        LH--ESLARIYT--------RGILEGLDFLHRR-GIVH-CDIK---------GKNVL-VG
STE11-p3-2_Smoe_STE11-plant3        LH--ESLARIYT--------RGILEGLEFLHRR-GIVH-CDIK---------GKNVL-VG
GK076_Glam_CDC15                    ST--EHLAALYV--------TQIVKGLIFIHYN-GYTH-KRIT---------PEHIL-IT
GK077_Glam_CDC15                    LG--ENVVACYI--------YQILLGLKYLHEQ-GIIH-KDIK---------AANIL-MT
GK078_Glam_STE11-Unclassified       IP--EILCRRYA--------RQILEAIKHMHRQ-NVAH-LDLK---------CSNIM-IG
                                                                             :.           :

MEKK15_Hsap_MEKK15                  P---TG-IIKLIDFGCARRLAWAGLN------------G---------------------
MAP3K7_Hsap_ASK                     T--YSG-VVKISDFGTSKRLAGVN------------------------------------
MAP3K6_Hsap_ASK                     T--FSG-LLKISDFGTSKRLAGIT------------------------------------
MAP3K5_Hsap_ASK                     T--YSG-VLKISDFGTSKRLAGIN------------------------------------
MAP3K4_Hsap_MEKK4                   S---SG-LIKLGDFGCSVKLKNNAQT----------------------------------
MAP3K3_Hsap_MEKK2                   S---AG-NVKLGDFGASKRLQTICM-----------------------------------
MAP3K2_Hsap_MEKK2                   S---TG-NVKLGDFGASKRLQTICL-----------------------------------
MAP3K1_Hsap_MEKK1                   S---TGQRLRIADFGAAARLASKG------------------------------------
MEKK15_Mmus_MEKK15                  P---TG-IIKLIDFGCAKRLAWAGLN------------G---------------------
MAP3K7_Mmus_ASK                     T--YSG-VVKISDFGTSKRLAGIN------------------------------------
MAP3K6_Mmus_ASK                     T--FSG-LLKISDFGTSKRLAGIT------------------------------------
MAP3K5_Mmus_ASK                     T--YSG-VLKISDFGTSKRLAGIN------------------------------------
MAP3K4_Mmus_MEKK4                   S---SG-LIKLGDFGCSVKLKNNAQT----------------------------------
MAP3K3_Mmus_MEKK2                   S---AG-NVKLGDFGASKRLQTICM-----------------------------------
MAP3K2_Mmus_MEKK2                   S---TG-NIKLGDFGASKRLQTICL-----------------------------------
MAP3K1_Mmus_MEKK1                   S---TGQRLRIADFGAAARLASKG------------------------------------
nsy-1_Cele_ASK                      T--YSG-VCKISDFGTCKRLAGLN------------------------------------
B0414.7_Cele_MEKK4                  K---CT-VLKLGDFGCSSRLVESSTV----------------------------------
STE11_Scer_STE11-Unclassified       I---KG-CVKITDFGISKKLSPLNK-----------------------------------
SSK22_Scer_STE11-Unclassified       F---NG-IIKYVDFGTARTVVGSRTR------------TVRNAAV---------------
SSK2_Scer_STE11-Unclassified        F---NG-VIKYVDFGAAKKIANNGTR------------LASMNKIENADGEHEDVTHVSD
CDC15_Scer_CDC15                    A---DN-TVKLADFGVSTIVNS--------------------------------------
BCK1_Scer_STE11-Unclassified        Q---DG-ICKISDFGISRKSKDIY------------------------------------
Pk92B_Dmel_ASK                      T--YSG-VVKISDFGTSKRLARIN------------------------------------
Mekk1_Dmel_MEKK4                    G---SN-SLKLGDFGSAVKIQAHT-T----------------------------------
DDB0229877_Ddis_CDC15               K---EG-VIKLADFGSCTYSAI--D-----------------------------------
DDB0229896_Ddis_CDC15               K---EG-KIKLADFGVATKFDDT-------------------------------------
DDB0229915_Ddis_CDC15               ---KEG-VIKLADFGVASQIDSESQ-----------------------------------
DDB0229971_Ddis_CDC15               K---AG-EAKLSDFGTAGEIIKESD-----------------------------------
DDB0231212_Ddis_CDC15               ---TDG-SIKLADFGVATKVSDLSS-----------------------------------
MEKKalpha_Ddis_STE11-Unclassified   T---KG-IVKLSDFGCSKSFSGIV------------------------------------
11359_Tthe_STE11-Unclassified       T---DG-TIKLTDFGTLKLHKKDAYINH----------SKSQS-----------------
15684_Tthe_STE11-Unclassified       S---DG-VCKLADFGLAKSISQEID-----------------------------------
18758_Tthe_STE11-Unclassified       S---DG-IVKLSDFGCAKQLELTLN-----------------------------------
23105_Tthe_STE11-Unclassified       G---NG-TVKLADFGAARYRDTICLP------------T---------------------
29763_Tthe_STE11-Unclassified       K---DG-NCKLADFGSAKKIVEEK------------------------------------
4322_Tthe_CDC15                     KNNKSG-VIKLTDFGVATHLADDDK-----------------------------------
6622_Tthe_STE11-Unclassified        G---QG-NVKLADFGAARNIENILQH------------S---------------------
7147_Tthe_STE11-Unclassified        A---EG-RAKLTDFGTAKQIEFDLRKSQ----------VK--------------------
MEKK1_Spur_MEKK1                    S---TGHHLRIADLGTAGKMNADI------------------------------------
MEKK2_Spur_MEKK2                    S---SG-NVKLADFGASTRLQTIHS-----------------------------------
MEKK4_Spur_MEKK4                    ------------------------HF----------------------------------
ASK_Spur_ASK                        T--YSG-VVKISDFGTSKRLAGLN------------------------------------
MEKK15_Spur_MEKK15                  S---TG-VIKLIDFGCAKRLCIQI-S----------------------------------
CC1G_00852_Ccin_CDC15               K---NG-NVKLSDFGVSLNLRAME------------------------------------
CC1G_05008_Ccin_CDC15               K---DG-TVKLADFGVAARTGGV-------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  N---KG-GVKISDFGISKKVDDNLLG----------------------------------
CC1G_10524_Ccin_STE11-Unclassified  H---SG-VCKISDFGISKKAGEINR-----------------------------------
CC1G_13687_Ccin_STE11-Unclassified  Q---LG-RIKFVDFGAAKILAKNQHT------------LQRSRRST-------DAA-F--
CC1G_10513_Ccin_STE11-Unclassified  M---TG-ICKISDFGISKRTDDLH------------------------------------
AqueK224_Aque_ASK                   M--YSG-QIKISDFG---------------------------------------------
AqueK225_Aque_MEKK1                 E--NVQ-RLKVTDFGCSQVLEDSHQ-----------------------------------
AqueK226_Aque_MEKK15                A---HG-TVKLIDFGCAKRHCLD--Q----------------------------------
AqueK227_Aque_MEKK2                 S---NG-NVKLADFGASKRLQTIR------------------------------------
AqueK228_Aque_MEKK4                 D---D--SVKLGDFGLSVQLHNVNKT----------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        N---QG-HIKVADFGASKKVLELA------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        N---QG-HIKVADFGASKKVLELA------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      A---DG-VVKLADFGASKAFHDPT------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        A---IG-VVKLADFGASKAFHDPT------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      A---DG-VVKLADFGASKAFHDPT------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        A---IG-VVKLADFGASKAFHDPT------------------------------------
NPK1-2_Smoe_NPK1                    K---EG-FVKLADFGVATKLTEADV-----------------------------------
NPK1-1_Smoe_NPK1                    KEVFQG-FVKLADFGVATKLTEADV-----------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      A---HG-TVKLADFGMAKQASY--------------------------------------
STE11-p2_j_Smoe_STE11-plant1        P---NG-KAKLADFGLAKKHRSHQ------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      A---HG-TVKLADFGMAKQASY--------------------------------------
STE11-p2_g_Smoe_STE11-plant2        T---NG-VVKLGDFGMAKHVRFVSSLIFFR-HSPRDCFQ---------------------
STE11-p2_c_Smoe_STE11-plant2        S---DG-NVKLADFGMAKHVTA--------------------------------------
STE11-p2_f_Smoe_STE11-plant2        T---NG-EVKLADFGMAKHISS--------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      T---NG-IVKLADFGMAKHVLNVFSSFLSLLLTSVSVFQ---------------------
STE11-p2_d-2_Smoe_STE11-plant2      T---NG-IVKLADFGMAKHVLNVFSLFLSLLLTSVSVFQ---------------------
STE11-p3-1_Smoe_STE11-plant3        A---TG--VKLADFGAAKRLSGAAP-----------------------------------
STE11-p3-2_Smoe_STE11-plant3        A---TG--VKLADFGAAKRLSGAAH-----------------------------------
GK076_Glam_CDC15                    N---DG-FVKISDFVLQNAYFADG------------------------------------
GK077_Glam_CDC15                    S---SG-LCKLTDFGLSQRLQDV-------------------------------------
GK078_Glam_STE11-Unclassified       G---DG-LVKLVDFGTATRLARDDII------------NE------LQRRKETEADPKKP


MEKK15_Hsap_MEKK15                  -----THSDMLKS-MHGTPYWMAPEV-------INE----------SGY-G-RKSDIWSI
MAP3K7_Hsap_ASK                     --------PCTET-FTGTLQYMAPEI-------IDQG--------PRGY-G-APADIWSL
MAP3K6_Hsap_ASK                     --------PCTET-FTGTLQYMAPEI-------IDQG--------PRGY-G-KAADIWSL
MAP3K5_Hsap_ASK                     --------PCTET-FTGTLQYMAPEI-------IDKG--------PRGY-G-KAADIWSL
MAP3K4_Hsap_MEKK4                   ------MPGEVNS-TLGTAAYMAPEV-------ITRAK-------GEGH-G-RAADIWSL
MAP3K3_Hsap_MEKK2                   ------SGTGMRS-VTGTPYWMSPEV-------ISG----------EGY-G-RKADVWSL
MAP3K2_Hsap_MEKK2                   ------SGTGMKS-VTGTPYWMSPEV-------ISG----------EGY-G-RKADIWSV
MAP3K1_Hsap_MEKK1                   ----TGAGEFQGQ-LLGTIAFMAPEV-------LRG----------QQY-G-RSCDVWSV
MEKK15_Mmus_MEKK15                  -----THSDMLKS-MRGTPYWMAPEV-------INE----------SGY-G-RKSDIWSI
MAP3K7_Mmus_ASK                     --------PCTET-FTGTLQYMAPEI-------IDQG--------PRGY-G-APADIWSL
MAP3K6_Mmus_ASK                     --------PCTET-FTGTLQYMAPEI-------IDQG--------PRGY-G-KAADIWSL
MAP3K5_Mmus_ASK                     --------PCTET-FTGTLQYMAPEI-------IDKG--------PRGY-G-KAADIWSL
MAP3K4_Mmus_MEKK4                   ------MPGEVNS-TLGTAAYMAPEV-------ITRAK-------GEGH-G-RAADIWSL
MAP3K3_Mmus_MEKK2                   ------SGTGIRS-VTGTPYWMSPEV-------ISG----------EGY-G-RKADVWSL
MAP3K2_Mmus_MEKK2                   ------SGTGMKS-VTGTPYWMSPEV-------ISG----------EGY-G-RKADIWSV
MAP3K1_Mmus_MEKK1                   ----TGAGEFQGQ-LLGTIAFMAPEV-------LRG----------QQY-G-RSCDVWSV
nsy-1_Cele_ASK                      --------PVTET-FTGTLQYMAPEV-------IDHG--------QRGY-G-APADIWSF
B0414.7_Cele_MEKK4                  -------YGEFQT-TAGTPQFMAPEI-------YSYGEKDETTGSYSGY-G-RSVDIWAL
STE11_Scer_STE11-Unclassified       ------KQNKRAS-LQGSVFWMSPEV-------VKQ----------TAT-T-AKADIWST
SSK22_Scer_STE11-Unclassified       -QDFGVETKSLNE-MMGTPMYMAPET-------ISGSA-------VKGK-L-GADDVWAL
SSK2_Scer_STE11-Unclassified        SKAVKNNENALLD-MMGTPMYMAPES-------ITGST-------TKGK-L-GADDVWSL
CDC15_Scer_CDC15                    ---------SALT-LAGTLNWMAPEI-------LGN----------RGA-S-TLSDIWSL
BCK1_Scer_STE11-Unclassified        -------SNSDMT-MRGTVFWMAPEM-------VDT---------KQGY-S-AKVDIWSL
Pk92B_Dmel_ASK                      --------PMTET-FTGTLQYMAPEV-------IDQG--------VRGY-G-PAADIWSF
Mekk1_Dmel_MEKK4                    ------VPGELQG-YVGTQAYMAPEV-------FTKTN-------SDGH-G-RAADIWSV
DDB0229877_Ddis_CDC15               ---------RKLT-VVGTPFWMAPEV-------IQMD--------MNAR-S-TACDIWSL
DDB0229896_Ddis_CDC15               ---------SAAA-VVGTPYWMAPEI-------IEL----------NGA-T-TKSDIWSV
DDB0229915_Ddis_CDC15               ---------LRFS-VVGTPYWMAPES-------IEI----------SGC-S-SASDIWSL
DDB0229971_Ddis_CDC15               ---------KRYS-VVGTPYWMAPEV-------IEI----------SGH-C-QVSDIWSL
DDB0231212_Ddis_CDC15               -------DNPDDT-FAGTPYWMAPEV-------IQM----------QGI-S-TACDVWSL
MEKKalpha_Ddis_STE11-Unclassified   --------SQFKS-MQGTPYWMAPEV-------IKQ----------TGH-G-RSSDIWSL
11359_Tthe_STE11-Unclassified       --QLSHNQLDYGTIQSQKPFWTAPEV-------LKN---------EDSH-D-ASSDIWSV
15684_Tthe_STE11-Unclassified       -------EGQLKL-PQGTPNWMAPEV-------CR-----------SGT-C-RFSDIWSL
18758_Tthe_STE11-Unclassified       -----SNKEMNKT-LKGSVPWMSPEI-------VTQ----------TKY-D-TKADIWSF
23105_Tthe_STE11-Unclassified       ----ADGSEFCNS-IKGSLYWMAPEL-------LNQ----------ESH-G-RKSDIWSL
29763_Tthe_STE11-Unclassified       --------GHNDS-IRGTPYWMAPET-------IKQ----------LGS-G-------SI
4322_Tthe_CDC15                     ---------SSTQ-CVGTPYWMAPEV-------IIDS---------DGHIS-TSCDIWSL
6622_Tthe_STE11-Unclassified        ----LSQSEFCNS-IKGSLYWMAPEL-------IKN----------EKH-G-RRIDVWSL
7147_Tthe_STE11-Unclassified        ---EEDIAKMNKS-LKGTPNWMAPEV-------IER----------TGH-T-TSADIWSI
MEKK1_Spur_MEKK1                    ----TRTDEFKGQ-FLGTISFMAPEV-------LRG----------EPY-G-RSCDIWSV
MEKK2_Spur_MEKK2                    ------HITGMKT-VTGTPYWMSPEI-------ING----------EGY-G-RRADVWSI
MEKK4_Spur_MEKK4                    ------MPYKIYS-KMLSAAYMAPEV-------INQTG-------KDGY-G-RQADIWSL
ASK_Spur_ASK                        --------PAASS-FKGTLQYMAPEV-------IDKG--------LRGH-G-APADIWSL
MEKK15_Spur_MEKK15                  -----RSQNVLKS-MRGTPYWMAPEV-------IME----------TGH-G-KKSDIWSI
CC1G_00852_Ccin_CDC15               --------REIKD-VAGTPNWMAPEV-------IEL----------KGA-S-IKSDIWSL
CC1G_05008_Ccin_CDC15               ---------VDGA-VVGSPYWMAPEV-------IEQ----------SGA-T-TASDIWSV
CC1G_12014_Ccin_STE11-Unclassified  -----GNRLHRPS-LQGSVFWMAPEV-------VKQ----------TGH-T-KKADIWSV
CC1G_10524_Ccin_STE11-Unclassified  -------AKAHTG-MKGTSFWMAPEI-------LSPG--------EKGY-D-VKVDIWSV
CC1G_13687_Ccin_STE11-Unclassified  -NAANGIGVMSNG-LTGTPMYMSPEM-------IKNDR--------RGR-H-GATDIWSL
CC1G_10513_Ccin_STE11-Unclassified  -------GGAFTA-MQGTVFWMAPEV-------INTQ--------KKGY-N-FKIDIWSV
AqueK224_Aque_ASK                   -----------------TFQFMAPEV-------IASG--------QRGY-G-PPADVWSL
AqueK225_Aque_MEKK1                 -----GYCMRGDA-NAGTVHYNPPEH-------YSE----------FRC-S-YALDIWQA
AqueK226_Aque_MEKK15                -------SLGFHS-VRGTPYWMAPEV-------ICG----------RGY-G-RKSDIWSL
AqueK227_Aque_MEKK2                 --------SGIGS-VHGTPYWMAPEV-------IKG---------DDPY-T-FKADIWSV
AqueK228_Aque_MEKK4                 ------APQEIKH-QRGTIPYMSPEV-------VLM----------QDM-G-RPMDIWAV
MEKK2-p1_a_Smoe_MEKK2-plant1        ------TISEAKS-MKGTPYWMAPEV-------VRQ----------TGH-N-WQADIWSV
MEKK2-p1_b_Smoe_MEKK2-plant1        ------TISEAKS-MKGTPYWMAPEV-------VRQ----------TGH-N-WQADIWSV
STE11-p2_b-2_Smoe_MEKK2-plant2      ------ITDGCKS-IRGSVFWMAPEV-------IKG----------DGY-G-RRADIWSV
STE11-p2_a_Smoe_MEKK2-plant2        ------VTNECKS-IRGSVFWMAPEV-------IKG----------DGY-G-RRADIWSV
STE11-p2_b-1_Smoe_MEKK2-plant2      ------ITDGCKS-IRGSVFWMAPEV-------IKG----------DGY-G-RRADIWSV
STE11-p2_h_Smoe_MEKK2-plant2        ------VTNECKS-IRGSVFWMAPEV-------IKG----------DGY-G-RRADIWSV
NPK1-2_Smoe_NPK1                    ---------NTHS-VVGTPYWMAPEV-------VEM----------SGV-S-ASSDIWSV
NPK1-1_Smoe_NPK1                    ---------NTHS-VVGTPYWMAPEV-------VEM----------SGV-S-ASSDIWSV
STE11-p2_e-2_Smoe_STE11-plant1      --------FFMRS-CKGSVYWMAPEV-------INP---------KKTA-G-FPADIWSL
STE11-p2_j_Smoe_STE11-plant1        -----IDYSVAKS-CKGTFVYMAPEV-------LLT---------EGTY-G-LAADVWSL
STE11-p2_e-1_Smoe_STE11-plant1      --------FFMRS-CKGSVYWMAPEV-------INP---------KKTA-G-FPADIWSL
STE11-p2_g_Smoe_STE11-plant2        ----ITAQSFPLS-CKGSPYWMAPEI-------LKS---------THGY-D-LSVDIWSL
STE11-p2_c_Smoe_STE11-plant2        -------KSFARS-LKGSPYWMAPERSLTFFQILKSR--------CSGY-D-LSVDIWSL
STE11-p2_f_Smoe_STE11-plant2        -------SSLVLS-FKGSPYWMAPEV-------FKS----------NAQ-S-YPVDIWSL
STE11-p2_d-1_Smoe_STE11-plant2      ----LSVESFPLS-FKGSPYWMAPEV-------IKQ---------THGY-D-LSVDVWSL
STE11-p2_d-2_Smoe_STE11-plant2      ----LSVESFPLS-FKGSPYWMAPEV-------IKQ---------THGY-D-LSVDVWSL
STE11-p3-1_Smoe_STE11-plant3        ----YQHHQQSPM-IKGTPLWMAPEV-------VRQ----------EEQ-G-TASDIWSL
STE11-p3-2_Smoe_STE11-plant3        ----YQHHQQSPM-IKGTPLWMAPEV-------VRQ----------EEQ-G-TASDIWSL
GK076_Glam_CDC15                    -------D--------KDVRDMAPEE-------ILL----------LGR-T-TAVDIWNL
GK077_Glam_CDC15                    ---------DPTV-VEGSPYWLAPEV-------INE----------EGV-S-TKSDVWSL
GK078_Glam_STE11-Unclassified       GLPSEAAKKFNLG-IKGSPYWIAPEC-------VRS----------TLY-DIFKADIWSI
                                                          .**

MEKK15_Hsap_MEKK15                  GCTVF----EMATGKPPLASMDR-----------M-AAMFYIGAHR--------GLMPPL
MAP3K7_Hsap_ASK                     GCTII----EMATSKPPFHELG-----------EPQAAMFKVGMF---------KIHPEI
MAP3K6_Hsap_ASK                     GCTVI----EMATGRPPFHELG-----------SPQAAMFQVGMY---------KVHPPM
MAP3K5_Hsap_ASK                     GCTII----EMATGKPPFYELG-----------EPQAAMFKVGMF---------KVHPEI
MAP3K4_Hsap_MEKK4                   GCVVI----EMVTGKRPWHEYEH-----------NFQIMYKVGM-G---------HKPPI
MAP3K3_Hsap_MEKK2                   GCTVV----EMLTEKPPWAEYE------------AMAAIFKIATQ---------PTNPQL
MAP3K2_Hsap_MEKK2                   ACTVV----EMLTEKPPWAEFE------------AMAAIFKIATQ---------PTNPKL
MAP3K1_Hsap_MEKK1                   GCAII----EMACAKPPWNAEKHS---------NHLALIFKIASA---------TTAPSI
MEKK15_Mmus_MEKK15                  GCTVF----EMATGKPPLASMDR-----------M-AAMFYIGAHR--------GLMPPL
MAP3K7_Mmus_ASK                     GCTII----EMATSRPPFHELG-----------EPQAAMFKVGMF---------KIHPEI
MAP3K6_Mmus_ASK                     GCTVI----EMATGRPPFHELG-----------SPQAAMFQVGMY---------KVHPPV
MAP3K5_Mmus_ASK                     GCTII----EMATGKPPFYELG-----------EPQAAMFKVGMF---------KVHPEI
MAP3K4_Mmus_MEKK4                   GCVVI----EMVTGKRPWHEYEH-----------NFQIMYKVGM-G---------HKPPI
MAP3K3_Mmus_MEKK2                   GCTVV----EMLTEKPPWAEYE------------AMAAIFKIATQ---------PTNPQL
MAP3K2_Mmus_MEKK2                   ACTVV----EMLTEKPPWAEFE------------AMAAIFKIATQ---------PTNPKL
MAP3K1_Mmus_MEKK1                   GCAII----EMACAKPPWNAEKHS---------NHLALIFKIASA---------TTAPSI
nsy-1_Cele_ASK                      GCTMV----EMATGRPPFVEMQ-----------NPQAAMFRVGMF---------KTHPPI
B0414.7_Cele_MEKK4                  GATVV----NMMTGKVPFEGQTRH------------QIAFALCFR---------KQKPTY
STE11_Scer_STE11-Unclassified       GCVVI----EMFTGKHPFPDFSQ-----------M-QAIFKIGTN----------TTPEI
SSK22_Scer_STE11-Unclassified       GCVVL----EMATGRRPWSNLDN-----------EWAIMYHVAA-G---------RIPQL
SSK2_Scer_STE11-Unclassified        GCVVL----EMITGRRPWANLDN-----------EWAIMYHVAA-G---------HTPQF
CDC15_Scer_CDC15                    GATVV----EMLTKNPPYHNLTD-----------A-NIYYAVEN-D---------TYYP-
BCK1_Scer_STE11-Unclassified        GCIVL----EMFAGKRPWSNLEV-----------V-AAMFKIGKS---------KSAPPI
Pk92B_Dmel_ASK                      GCTNV----EMATGKPPFIELG-----------SAHAAMFKVGFY---------KKHPNI
Mekk1_Dmel_MEKK4                    GCVVV----EMASGKRPWAQFDS-----------NFQIMFKVGM-G---------EKPQA
DDB0229877_Ddis_CDC15               GCTLL----EMLTGNPPYWDLGT-----------M-PAMFAMVN-N---------PHPPI
DDB0229896_Ddis_CDC15               GCTVI----ELLTGSPPYYDLGQ-----------M-PALFRIVQ-D---------DCPPL
DDB0229915_Ddis_CDC15               GSTMI----ELLTGNPPYYTLQP-----------M-AAMFRIVS-D---------QHPPF
DDB0229971_Ddis_CDC15               GCTII----ELFTSYPPYFDLNP-----------L-GAMYRICQ-D---------DRPPL
DDB0231212_Ddis_CDC15               GCTII----ELLTGTPPYFGLAP-----------A-AALYKIVQ-E---------DHPPI
MEKKalpha_Ddis_STE11-Unclassified   GCVIV----EMATAQPPWSNITE-----------LAAVMYHIASS---------NSIPNI
11359_Tthe_STE11-Unclassified       GCLVI----EMITALPPYYNLNDK----------SSQEITKYIMD---------GNIPNF
15684_Tthe_STE11-Unclassified       GCTVY----EMITGKPPFSNFLAE------------TIILRVGLL---------KQPPQF
18758_Tthe_STE11-Unclassified       GCTIL----EMAQAEAPWSNYQFD---------NPIAAIMKIGLS---------DEIPQI
23105_Tthe_STE11-Unclassified       GCTMI----EMATGKHPWPDCR------------TFPQLALIVKT---------NQCPPI
29763_Tthe_STE11-Unclassified       GCTVI----EMATAKPPWADKS------------PIQAMFYIANA---------QQPPPI
4322_Tthe_CDC15                     GCTII----ELLTGNPPYSYGNP-----------H-HALFRMVS-D---------QHPPL
6622_Tthe_STE11-Unclassified        GCTVI----EMASAQHPWENIK------------KFSDLANAVIE---------QQPIPI
7147_Tthe_STE11-Unclassified        GCIVI----EMITGKPPYPGLSAK------------EVFTKIASG---------------
MEKK1_Spur_MEKK1                    GCCII----EMCTTKPPWNNTAIS---------NHYQLLFKIASA---------NGPPPI
MEKK2_Spur_MEKK2                    GCTVV----EMLTTKPPWADYE------------AMAAIFKIATK---------ETEPVL
MEKK4_Spur_MEKK4                    GCVVI----EMVTGKRPWHDYDH-----------EFTIMYKVGE-G---------AVPHI
ASK_Spur_ASK                        GCTIV----EMATGKPPFIELG-----------SPQAAMFKVGFY---------KDHPEI
MEKK15_Spur_MEKK15                  GCTVF----EMATRKPPWADMPP-----------M-AAIFAIGSG---------DPVPQL
CC1G_00852_Ccin_CDC15               GCTHVWYVKEFHRRSLPWFNHD-------------ATVMFRIVE-D---------DMPPL
CC1G_05008_Ccin_CDC15               GCVVI----ELLEGRPPYHNLDP-----------M-PALFRIVQ-D---------DCPPI
CC1G_12014_Ccin_STE11-Unclassified  GCLVV----EMLTGEHPWAQLTQ-----------M-QAIFKIGSS----------ARPTI
CC1G_10524_Ccin_STE11-Unclassified  GCVAV----EMWTGKRPWYGHEW-----------W-PVLMKVAED---------KSPPPI
CC1G_13687_Ccin_STE11-Unclassified  GCVIL----QCATGRKPWSNLDN-----------EWAIMFHIGVST---------QHPPL
CC1G_10513_Ccin_STE11-Unclassified  GCVVL----EMWGGRRPWTGQEM-----------V-TVMFKLYEA---------KLPPPV
AqueK224_Aque_ASK                   GCTVI----EMVTGKPPFFELG-----------PPEAAVFKVGTF---------KEHPEI
AqueK225_Aque_MEKK1                 GCCII----AMVTGRRPWRSMYLDCRERRYRAEVQQSQIQQICKV---------PYSHHV
AqueK226_Aque_MEKK15                GCTMY----EMIFTRPPWGDLPP-----------E-AAMFKIGLG---------QSLPPL
AqueK227_Aque_MEKK2                 GATVV----EMLKCRPPWSDFE------------PTAAMFKIVMN---------DTKPDL
AqueK228_Aque_MEKK4                 GCVVV----EMFTSKRPWIELED----------NAMAIMFQLGN-K---------KSPSY
MEKK2-p1_a_Smoe_MEKK2-plant1        GCTVI----EMATGKPPWSDQF-----------QEVAALFHIGTT---------KSHPPI
MEKK2-p1_b_Smoe_MEKK2-plant1        GCTVI----EMATGKPPWSDQF-----------QEVAALFHIGTT---------KSHPPI
STE11-p2_b-2_Smoe_MEKK2-plant2      GCTVI----EMLTATHPWPGID-----------NTWTAIFHIAKA---------SSGPPV
STE11-p2_a_Smoe_MEKK2-plant2        GCTVI----EMLTAMHPWPDID-----------NTWSAIFHIAKA---------SSGPPI
STE11-p2_b-1_Smoe_MEKK2-plant2      GCTVI----EMLTATHPWPGID-----------NTWTAIFHIAKA---------SSGPPV
STE11-p2_h_Smoe_MEKK2-plant2        GCTVI----EMLTAMHPWPDID-----------NTWSAIFHIAKA---------SSGPPI
NPK1-2_Smoe_NPK1                    GCTVI----ELLTCVPPYYDLQP-----------M-PALFRIVQ-D---------ERPPI
NPK1-1_Smoe_NPK1                    GCTVI----ELLTCVPPYYDLQP-----------M-PALFRIVQ-D---------AK---
STE11-p2_e-2_Smoe_STE11-plant1      GCTVL----EMATGKPPFSDWE------------WNTVFFRVGR----------GALPEI
STE11-p2_j_Smoe_STE11-plant1        GCTVI----EMACGKPPWSGFG------------VRSLTFTSMRD---------GCSPPI
STE11-p2_e-1_Smoe_STE11-plant1      GCTVL----EMATGKPPFSDWE------------WNTVFFRVGR----------GALPEI
STE11-p2_g_Smoe_STE11-plant2        GCTVI----EMATGKPPWSEFE------------GVAVMFKIGNS---------KETPPI
STE11-p2_c_Smoe_STE11-plant2        GCTVI----EMAQARPPWSDYE------------AVPVLYKLATT---------LETPRV
STE11-p2_f_Smoe_STE11-plant2        GCTII----EMATGKPPWSQYE------------GIAAMFKIGNS---------KETPTI
STE11-p2_d-1_Smoe_STE11-plant2      GCTVL----EMATAKPPWSQYE------------GIAAMFKIGNS---------KEIPSI
STE11-p2_d-2_Smoe_STE11-plant2      GCTVL----EMATAKPPWSQYE------------GIAAMFKIGNS---------KEIPSI
STE11-p3-1_Smoe_STE11-plant3        GCTVL----EMITGRAPWGDVK-----------HTFSALYRIGCS---------EELPEL
STE11-p3-2_Smoe_STE11-plant3        GCTVL----EMITGRAPWGDVK-----------HTFSALYRIGCS---------EELPEL
GK076_Glam_CDC15                    GLLLF----NCLAREHFFKNMADQ----------EIIRLFQSTNAQNTINELVTFRLAEC
GK077_Glam_CDC15                    GATMI----ELLTKKPPFHNLTG-----------F-AAMYNIAT-L---------TEMPL
GK078_Glam_STE11-Unclassified       GCLFI----EMFTTYPPFFQFKQ-----------VPALLYHIATI---------TEPPGL
                                    .

MEKK15_Hsap_MEKK15                  P--DH----FSENAADFVRMCLT--------------------------RDQHERPSALQ
MAP3K7_Hsap_ASK                     P--EA----LSAEARAFILSCFE--------------------------PDPHKRATTAE
MAP3K6_Hsap_ASK                     P--SS----LSAEAQAFLLRTFE--------------------------PDPRLRASAQT
MAP3K5_Hsap_ASK                     P--ES----MSAEAKAFILKCFE--------------------------PDPDKRACAND
MAP3K4_Hsap_MEKK4                   P--ER----LSPEGKDFLSHCLE--------------------------SDPKMRWTASQ
MAP3K3_Hsap_MEKK2                   P--SH----ISEHGRDFLRRIF---------------------------VEARQRPSAEE
MAP3K2_Hsap_MEKK2                   P--PH----VSDYTRDFLKRIF---------------------------VEAKLRPSADE
MAP3K1_Hsap_MEKK1                   P--SH----LSPGLRDVALRCLE--------------------------LQPQDRPPSRE
MEKK15_Mmus_MEKK15                  P--AR----FSEPAADFVRLCLT--------------------------RDQHERPSALQ
MAP3K7_Mmus_ASK                     P--EA----LSAEARAFILSCFE--------------------------PDPQKRVTAAD
MAP3K6_Mmus_ASK                     P--GS----LSAEAQAFLLRTFE--------------------------PDPRLRASAQE
MAP3K5_Mmus_ASK                     P--ES----MSAEAKAFILKCFE--------------------------PDPDKRACAND
MAP3K4_Mmus_MEKK4                   P--ER----LSPEGKAFLSHCLE--------------------------SDPKIRWTASQ
MAP3K3_Mmus_MEKK2                   P--SH----ISEHGRDFLRRIF---------------------------VEARQRPSAEE
MAP3K2_Mmus_MEKK2                   P--PH----VSDYTRDFLKRIF---------------------------VEAKLRPSAEE
MAP3K1_Mmus_MEKK1                   P--SH----LSPGLRDVALRCLE--------------------------LQPQDRPPSRE
nsy-1_Cele_ASK                      P--TE----ITEKCRNFIKSCFL--------------------------PEACDRPSAKD
B0414.7_Cele_MEKK4                  P--DIA--DKRPDVKRFFDNCFE--------------------------FLPNDRPTAAE
STE11_Scer_STE11-Unclassified       P--SW----ATSEGKNFLRKAFE--------------------------LDYQYRPSALE
SSK22_Scer_STE11-Unclassified       PNRDE----MTAAGRALLGKVFG--------------------------SRPH-------
SSK2_Scer_STE11-Unclassified        PTKDE----VSSAGMKFLERCLI--------------------------QNPSKRASAVE
CDC15_Scer_CDC15                    P--SS----FSEPLKDFLSKCFV--------------------------KNMYKRPTADQ
BCK1_Scer_STE11-Unclassified        P--EDTLPLISQIGRNFLDACFE--------------------------INPEKRPTANE
Pk92B_Dmel_ASK                      P--EE----LSANAKNFILRCFA--------------------------ISVMDRPSASQ
Mekk1_Dmel_MEKK4                    P--ES----LSQEGHDFIDHCLQ--------------------------HDPKRRLTAVE
DDB0229877_Ddis_CDC15               P--NN----ISADLKHFLLACFV--------------------------RDINKRPTASQ
DDB0229896_Ddis_CDC15               P--EG----ISPPLKDWLMQCFQ--------------------------KDPNLRISAQK
DDB0229915_Ddis_CDC15               P--TD----ISKEFLDYFQQSFK--------------------------KDPTQRPTAQE
DDB0229971_Ddis_CDC15               P--DD----ISSELANFLERCFC--------------------------KSTEERATAKE
DDB0231212_Ddis_CDC15               P--PG----ISAALKDFLLNCFK--------------------------KDENIRSSAKQ
MEKKalpha_Ddis_STE11-Unclassified   P--SH----MSQEAFDFLNLCFK--------------------------RDPKERPDANQ
11359_Tthe_STE11-Unclassified       P--EK----LSEQCLEFLQKTLK--------------------------VNPKERATVNE
15684_Tthe_STE11-Unclassified       L--ENL--QISEKLSDFLLHCFQ--------------------------IKPEERWNVDQ
18758_Tthe_STE11-Unclassified       P--ET----ISPDLNQFIRKCLQ--------------------------RDPSKRPTATE
23105_Tthe_STE11-Unclassified       P--EH----LSDECKDFIRQCCT--------------------------FDKKERPTADV
29763_Tthe_STE11-Unclassified       P--EH----LSPVCKDFISKCLK----YQNQIELVDLTKTQQILFLQFRINPNDRYNVRQ
4322_Tthe_CDC15                     P--KD----VTPQCLDFLMQCFN--------------------------KEPSQRMDAKS
6622_Tthe_STE11-Unclassified        P--QH----LSEECKDFISKCCT--------------------------YDKKMRPKSQQ
7147_Tthe_STE11-Unclassified        -------------------GCLQ--------------------------TDPKKRLTTSQ
MEKK1_Spur_MEKK1                    P--ES----LSPALRDITLRCLE--------------------------AEPSARPGVME
MEKK2_Spur_MEKK2                    P--QS----VSQDARNFLTLCFK--------------------------KILADRPSAAE
MEKK4_Spur_MEKK4                    P--DA----MNPEGKEFLSNCLK--------------------------HDCTKRWTANK
ASK_Spur_ASK                        P--ES----LSNAAKEFILRCFE--------------------------PDPEKRATAHD
MEKK15_Spur_MEKK15                  P--VK----FSEDARMFVNACLT--------------------------RDQDERATASE
CC1G_00852_Ccin_CDC15               P--EG----CSELLEDFLKQCLQ--------------------------KDPNNRPTAEL
CC1G_05008_Ccin_CDC15               P--EG----ASAIVKDFLYHCFQ--------------------------KDCNLRISAKK
CC1G_12014_Ccin_STE11-Unclassified  P--SD----ISAEAQDFLQKTFE--------------------------INHELRPHAAE
CC1G_10524_Ccin_STE11-Unclassified  P--EDI--PMGHLAQSFHNQCFR--------------------------PDPADRPHASV
CC1G_13687_Ccin_STE11-Unclassified  PEPGQ----LSPLGIDFIKQCLT--------------------------IDPTFRPSAKE
CC1G_10513_Ccin_STE11-Unclassified  P--DDV--VLSELGDDFRRKCFAIFMTD------------------GACSNPDERPPAAE
AqueK224_Aque_ASK                   P--DV----LSKELKSFLLSCFE--------------------------PEPSKRAIVSE
AqueK225_Aque_MEKK1                 P--GF----LDPALQQLVQQCLS--------------------------IDYRRRPSLKD
AqueK226_Aque_MEKK15                P--KN----SSMELISLYTACLK--------------------------SDPGQRPTAQE
AqueK227_Aque_MEKK2                 P--PH----CSEQAHNFIELCFI--------------------------KDKNERPSAMD
AqueK228_Aque_MEKK4                 PA-EK----MNDEMIDFLDLCFE--------------------------TDPKQRAVASK
MEKK2-p1_a_Smoe_MEKK2-plant1        P--EH----LSPDAKSFLLKCLQ--------------------------REPRLRPTAAE
MEKK2-p1_b_Smoe_MEKK2-plant1        P--EH----LSPDAKSFLLKCLQ--------------------------REPRLRPTAAE
STE11-p2_b-2_Smoe_MEKK2-plant2      P--AD----ASEGAKDFLQQCFN--------------------------LEARSRPTASQ
STE11-p2_a_Smoe_MEKK2-plant2        P--EH----GSGCVKDFLQQCFQ--------------------------MDPRLRPTATQ
STE11-p2_b-1_Smoe_MEKK2-plant2      P--AD----ASECAKDFLQQCFN--------------------------LEARSRPTASQ
STE11-p2_h_Smoe_MEKK2-plant2        P--EH----GSGCVKDFLQQCFQ--------------------------MDPRLRPTATQ
NPK1-2_Smoe_NPK1                    P--EH----LSPGLTDFLHQCFQ--------------------------KDAKLRPDAKT
NPK1-1_Smoe_NPK1                    -----------------------------------------------------LR-----
STE11-p2_e-2_Smoe_STE11-plant1      P--DS----IQGDARDFILECLQ--------------------------ADPSKRPTASK
STE11-p2_j_Smoe_STE11-plant1        P--PK----MSTEAVSFIKLCLT--------------------------RDPRRRPSAAA
STE11-p2_e-1_Smoe_STE11-plant1      P--DS----IQGDARDFILECLQ--------------------------ADPSKRPTASK
STE11-p2_g_Smoe_STE11-plant2        P--PH----LSEECQHFLRLCLQ--------------------------RNPADRPTATE
STE11-p2_c_Smoe_STE11-plant2        P--DF----LSDQAKDFLRLCLQ--------------------------RDPSHRPTASQ
STE11-p2_f_Smoe_STE11-plant2        P--DT----LSPVAKEFIRLCLQ--------------------------RNPDDRPTASQ
STE11-p2_d-1_Smoe_STE11-plant2      P--EY----LTRECKNFLRLCLQ--------------------------RNPAERPTATF
STE11-p2_d-2_Smoe_STE11-plant2      P--EY----LTRECKNFLRLCLQ--------------------------RNPAERPTATF
STE11-p3-1_Smoe_STE11-plant3        P--RW----LSEQGKDFVMNCLR--------------------------RDPRERWTSAQ
STE11-p3-2_Smoe_STE11-plant3        P--WW----LSEQGKDFVMNCLR--------------------------RDPRERWTSAQ
GK076_Glam_CDC15                    N--LN----VSQACKEFILACLS--------------------------IDYTFRPSAQS
GK077_Glam_CDC15                    P--PN----ISPECADFLSCCFK--------------------------IDPHERHSCAE
GK078_Glam_STE11-Unclassified       P--ET----MSDEGRDFLSKCLQ--------------------------INPEARASVDD


MEKK15_Hsap_MEKK15                  LLKHSFL
MAP3K7_Hsap_ASK                     LLREGFL
MAP3K6_Hsap_ASK                     LLGDPFL
MAP3K5_Hsap_ASK                     LLVDEFL
MAP3K4_Hsap_MEKK4                   LLDHSFV
MAP3K3_Hsap_MEKK2                   LLTHHFA
MAP3K2_Hsap_MEKK2                   LLRHMFV
MAP3K1_Hsap_MEKK1                   LLKHPVF
MEKK15_Mmus_MEKK15                  LLKHSFL
MAP3K7_Mmus_ASK                     LLQEGFL
MAP3K6_Mmus_ASK                     LLGDPFL
MAP3K5_Mmus_ASK                     LLIDEFL
MAP3K4_Mmus_MEKK4                   LLDHAFV
MAP3K3_Mmus_MEKK2                   LLTHHFA
MAP3K2_Mmus_MEKK2                   LLRHMFV
MAP3K1_Mmus_MEKK1                   LLKHPVF
nsy-1_Cele_ASK                      LLQDPFI
B0414.7_Cele_MEKK4                  LLQTTFA
STE11_Scer_STE11-Unclassified       LLQHPWL
SSK22_Scer_STE11-Unclassified       -----YE
SSK2_Scer_STE11-Unclassified        LLMDPWI
CDC15_Scer_CDC15                    LLKHVWI
BCK1_Scer_STE11-Unclassified        LLSHPFS
Pk92B_Dmel_ASK                      LLEDPFL
Mekk1_Dmel_MEKK4                    LLEHNFC
DDB0229877_Ddis_CDC15               LLEHPWI
DDB0229896_Ddis_CDC15               LLKHKWI
DDB0229915_Ddis_CDC15               LLQHPIF
DDB0229971_Ddis_CDC15               LLSHPWI
DDB0231212_Ddis_CDC15               LLHHPWV
MEKKalpha_Ddis_STE11-Unclassified   LLKHPFI
11359_Tthe_STE11-Unclassified       LIQLKFI
15684_Tthe_STE11-Unclassified       LLQHPFI
18758_Tthe_STE11-Unclassified       LLNDSFL
23105_Tthe_STE11-Unclassified       LLKHPFL
29763_Tthe_STE11-Unclassified       LLNHPFI
4322_Tthe_CDC15                     LLNHEWL
6622_Tthe_STE11-Unclassified        LFNHPFL
7147_Tthe_STE11-Unclassified        LLKTPFI
MEKK1_Spur_MEKK1                    LLKHPAF
MEKK2_Spur_MEKK2                    LLRHNFV
MEKK4_Spur_MEKK4                    LLDHPFL
ASK_Spur_ASK                        LLQDPFL
MEKK15_Spur_MEKK15                  LLKHPFI
CC1G_00852_Ccin_CDC15               LCEHEWL
CC1G_05008_Ccin_CDC15               LLKHPWM
CC1G_12014_Ccin_STE11-Unclassified  LLQHPWL
CC1G_10524_Ccin_STE11-Unclassified  MLKHPYL
CC1G_13687_Ccin_STE11-Unclassified  LMDHPWM
CC1G_10513_Ccin_STE11-Unclassified  LRLHPYL
AqueK224_Aque_ASK                   LLQNSFI
AqueK225_Aque_MEKK1                 CLG--LL
AqueK226_Aque_MEKK15                VLDHAFL
AqueK227_Aque_MEKK2                 LLSHSFC
AqueK228_Aque_MEKK4                 LLSHSFV
MEKK2-p1_a_Smoe_MEKK2-plant1        LLKVCAL
MEKK2-p1_b_Smoe_MEKK2-plant1        LLKVCAL
STE11-p2_b-2_Smoe_MEKK2-plant2      ------V
STE11-p2_a_Smoe_MEKK2-plant2        VF-YPCL
STE11-p2_b-1_Smoe_MEKK2-plant2      ------V
STE11-p2_h_Smoe_MEKK2-plant2        LLEHRFV
NPK1-2_Smoe_NPK1                    LLKHSWI
NPK1-1_Smoe_NPK1                    ------P
STE11-p2_e-2_Smoe_STE11-plant1      LLDHPFV
STE11-p2_j_Smoe_STE11-plant1        LLSHPFF
STE11-p2_e-1_Smoe_STE11-plant1      LLDHPFV
STE11-p2_g_Smoe_STE11-plant2        LMEHPFV
STE11-p2_c_Smoe_STE11-plant2        LFFHPWF
STE11-p2_f_Smoe_STE11-plant2        LLEHPFV
STE11-p2_d-1_Smoe_STE11-plant2      LLGHPFV
STE11-p2_d-2_Smoe_STE11-plant2      LLGHPFV
STE11-p3-1_Smoe_STE11-plant3        LLQHPFV
STE11-p3-2_Smoe_STE11-plant3        LLQHPFV
GK076_Glam_CDC15                    LLQASFL
GK077_Glam_CDC15                    LLNHPWL
GK078_Glam_STE11-Unclassified       LLAHPWV