PIK3R4_Hsap MGNQLA--GIAPSQ-ILSVESYFSD-I-HD--FEYDKSLG-STRFFKVARA-KHR--EG-
PIK3R4_Mmus MGNQLA--GIAPSQ-ILSVESYFSD-I-HD--FEYDKSLG-STRFFKVARA-KHR--EG-
CG9746_Dmel MGNQLV--GIAPSQ-IYAVEHYFSGQFGSE--IAFSSNMG-STRFFKVAKA-KTD--EG-
ZK930.1_Cele MGNINSLFTTNPSE-ILPVEVYLND-LS--CD--AVENLG-STRFMKVARG-RTH--EG-
VPS15_Scer MGAQLS--LVVQASPSIAIFSYIDV-L-EE--VHYVSQLN-SSRFLKTCKA-LDP--NG-
Vps15_Ddis MGNTVG--API-------VSEYLED-EIGP--IVFKKSLG-NARFLKTVKA-YHSE-EG-
15015_Tthe MSETKTISTLKKFD-IFA--------------LPFQFTFGNNEKEKKTIIGGLISM-AI-
VPS15_Spur MGNQLT--GVAPSQ-ILPVEHYLTD-V-SD--YEFDHSLG-STRFFKVARA-KYK--EG-
CC1G_08691_Ccin MGNVHS--GSTFTRTTGALDSYVAD-LGTD--IIYEKSLG-SSRFLKTVKC-KHR--NG-
AqueK216_Aque MGNQLT--ALAPAQ-ILPMESYFHD-LP-D--FGKPVSLG-STRFMKVARS-KYT--DGT
VPS15-1_Smoe MGNKLA--RTT--Q-ASPTEYYLND-LPSEFNLVLKEVIGKSERFFKAILC-VHD--EG-
VPS15-2_Smoe MGNKLA--RTT--Q-ASPTEYYLND-LPSEFNLVLKEVIGKSERFFKAILC-VHD--EG-
GK073_Glam MGNRLS--TLMSPG-IFSKK-YMIPWN-VK--VTSFEALN-TSRFLKSYHA-ENPQTKQ-
*. :. . : *
PIK3R4_Hsap LVVVKVFAIQDPTLPLTSYKQELEELKIRL--NSAQNCLPFQKASEKASEKAAMLFRQYV
PIK3R4_Mmus LVVVKVFAIQDPTLPLTSYKQELEELKIRL--HSAQNCLPFQKAAEKASEKAAMLFRQYV
CG9746_Dmel QIVVKVFVKHDPTLPLEDHKERLEGIKKTLSLANAVNCLPFQRVEL--IDKAAYIMREYV
ZK930.1_Cele VFVYKVFVRQD-LASLDPFPQRIIDIRKALM--KSPNCCPIKKVLV--KQKYAVMVRAFQ
VPS15_Scer EIVIKVFIKPKDQYSLRPFLQRIRAQSFKL--GQLPHVLNYSKLIE--TNRAGYMIRQHL
Vps15_Ddis YVVVKIYKKRNTKESLEKYKIMLKEIKDNFNITPSFNIMPYQHFIE--TDRSGYLIRQYF
15015_Tthe LIVSSIY--------------------------------------------FGYLCYLYF
VPS15_Spur LAVVKVFVIHDPSLPLRSFKEKIEDIKTRL--SNGSNCLPFLRSTL--SDKAALLFRQYV
CC1G_08691_Ccin YLVIKIFVKPDPGLTLRNYHKRLKNDKESLV--DIANVYNYQVFVE--TERAGYIIRQWV
AqueK216_Aque EVVVKIFPKIDSSVQLQMYEKRLHDINMRLR--FIANVLPYQNFWD--SDKAAFLVRQHV
VPS15-1_Smoe LLLVKVYFKRGDVLDLREHARKLNEIREQFRNVENSHVWPFQRWHE--TDKAAYLLRQYF
VPS15-2_Smoe LLLVKVYFKRGDVLDLREHARKLNEIREQFRNVENSHVWPFQRWHE--TDKAAYLLRQYF
GK073_Glam DFILKVFVKLED-IDLSIFKFMLSHYREKINR-CCPHVLPYMGEYE--SKTHGFLIRPML
: .:: . :
PIK3R4_Hsap RDNLYDRI------STRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWN
PIK3R4_Mmus RDNLYDRI------STRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWN
CG9746_Dmel KHSLYDRV------STRPFLTVLEKKWITFQILCALNQCHKQKICHGDIKLENILITSWN
ZK930.1_Cele KHTLFDRL------STRPFVVEAEKMWYIFLLFKALSQCETAGVCHGDLKSQNVLISSTN
VPS15_Scer KNNLYDRL------SLRPYLQDIELKFIAFQLLNTLKDIHNLNIVHGDIKTENILVTSWN
Vps15_Ddis HNNLYDRL------STRPFLSMIEKKFIAFQLLKALEQSSFKGVFHGDIKSENVLVTTSN
15015_Tthe QNKVQPQVVSSNIFQKSPYTMQFQQNFISVQVIMPNG-----------------------
VPS15_Spur RNNLYDRI------STRPFLISIEKKWIAFQLLCALNQAHL-------------------
CC1G_08691_Ccin ASNLYDRI------STRPFLTMVEKRWISFQLLNALRDARNRKVSHGDIKSENILVTSWN
AqueK216_Aque QYNLYDRI------STRPYLNNIEKKWIVFQLLKALEGCHEKKVYHGDLKTENVLLTGWG
VPS15-1_Smoe FSNLHERL------STRPFLSTIQKKWLAFQLLHAVKQSHDRGVCHGDIKCENVLVTSWN
VPS15-2_Smoe FSNLHERL------STRPFLSTIQKKWLAFQLLHAVKQSHDRGVCHGDIKCENVLVTSWN
GK073_Glam YQSLPEFI------LQNPWLTRGHKVLYSIQMILAVKEMHEAGLVHGDIKLSNFLVTHTH
.: : *: . . :: .
PIK3R4_Hsap WVLLTDFASF-KPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPS
PIK3R4_Mmus WVLLTDFASF-KPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPS
CG9746_Dmel WILLSDFASF-KPTYLPEDNPADYTYFFDTSRRRTCYIAPERFVKTLASDDDGG-NGNMS
ZK930.1_Cele WLQITDFAPF-KPCFLTHDNPSSFTFFFDTSRRQSCYIAPERFISATEYDEKLRD-----
VPS15_Scer WCILTDFAAFIKPVYLPEDNPGEFLFYFDTSKRRTCYLAPERFNSKLYQD----------
Vps15_Ddis WVYLSDFACY-KPTFIPEDNPADFSFYFDTSGRRTCYIAPERFYETNRGA----------
15015_Tthe ------------------------------------------------------------
VPS15_Spur ----------------VGDNPADFSFFFDTSRRRTCYIAPERFVEGSSSRPVD-SATSET
CC1G_08691_Ccin WVYLTDFASY-KPTYLPLDDPSDFSFYFDTSGRRTCYLAPERFYTQANNPDIS-AKKS-R
AqueK216_Aque WVFLTDFASF-KPTLLPADNPADYTFFFDTSRRRNCYVAPERFVHASSYSQSS-S-----
VPS15-1_Smoe WIYLTDFASF-KPTYIPDDNPADFSFFFDTGGRRRCYLAPERFYDPKTES----------
VPS15-2_Smoe WIYLTDFASF-KPTYIPDDNPADFSFFFDTGGRRRCYLAPERFYDPKTES----------
GK073_Glam SLMLTDFAPF-KPYQVSMSNPVALSYYFTD------TIAPERIVQADEELDT--------
PIK3R4_Hsap ---------------------------------------T-PLVDLN-SNQRTRGELKRA
PIK3R4_Mmus ---------------------------------------T-PLVDLN-SNQRARGELKRA
CG9746_Dmel VI-----------------------------------HTD-SIIR-L-APSYAGNTLLPA
ZK930.1_Cele ----------------------------------------------G-QDEWLFGSLTPK
VPS15_Scer -------------------------------------------------GKSNNGRLTKE
Vps15_Ddis ---------------------------------------------------PSNNELTPK
15015_Tthe ------------------------------------------------------------
VPS15_Spur VEGLQVRQDVKGGELTPAMDIFSVGFVEGSSSRPVDNATSETVEGLQVRQDVKGGELTPA
CC1G_08691_Ccin ---------------------------------------I-AA-MED-TPGKRDGKVTEA
AqueK216_Aque --------------------------------------------ASD--SFQRNKPLTYE
VPS15-1_Smoe -------------------------------------------------PVSPGGALKPS
VPS15-2_Smoe -------------------------------------------------PVSPGGPLTPS
GK073_Glam -----------------------------------------------------LLLPTME
PIK3R4_Hsap MDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFF-----PEQVL-NKIED--HSIRELV
PIK3R4_Mmus MDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFF-----PEQVL-NKIED--RSIRDLV
CG9746_Dmel MDIFSAGCALLELWTEGTAPFELSQLLAYRRGERDL----VEKHL-AGIEN--ERLRNLL
ZK930.1_Cele MDMFSAGCIVFELLCDR-PPFTYSSLCEYRSMNDAD---AGNMLL-RLIQDVPAPYRPLL
VPS15_Scer MDIFSLGCVIAEIFAEGRPIFNLSQLFKYKSNSYDV---NREFLM-EEMNS--TDLRNLV
Vps15_Ddis MDIFSLGCVIAELFLDGFPIFDFSQLLSYRKGEYS-----PEPIIRQRIQD--PNIQTLI
15015_Tthe -----------------QNLYDYQQQTG---KV----YL-NIISIN-FKSG--VNFKF--
VPS15_Spur MDIFSVGCVIAELFTEGNAPFDLSQLLAYCSGAYS-----PDAVL-EQIED--EHIKDLC
CC1G_08691_Ccin MDCFSAGCVIAELFLEGAPLFTLSQLFKYREGELN-----VDTQL-ASIED--EGIRNLI
AqueK216_Aque MDIFSLGCVTAELFLDGQLIFNLSELLDYCQKEFS-----PEPLL-KKITD--KYIKKMV
VPS15-1_Smoe MDMFSLGCVIAELFLEGQALFDLSQLLGYRKRLYD-----PLPSL-EKISD--TGIKNMI
VPS15-2_Smoe MDMFSLGCVIAELFLEGQALFDLSQLLGYRKRLYD-----PLPSL-EKISD--TGIKNMI
GK073_Glam ADVFSLGSALLELWTSI-KPFDLPTLFEYRDAKTGNIINYVLSLL-DHITH--EELRGLV
: : :
PIK3R4_Hsap TQMIHREPDKRLEAED-YLKQQRGNAFPEIFY-TFL-QPYMAQFAKETFL----------
PIK3R4_Mmus TQMINREPEKRLEAED-YLKQQRGNAFPEIFY-TFL-QPYMAQFAKETFL----------
CG9746_Dmel ASMIDIHSMNRKSAED-YLDQERGQLFPEYFY-SFL-QSYLQMFSSTPIM----------
ZK930.1_Cele RLLLNRDPSFRISANA-VLTG-AALKFPHILE-SFL-FKYLDRFRPLYGTSTSSDP----
VPS15_Scer LDMIQLDPSKRLSCDE-LLNKYRGIFFPDYFY-TFI-YDYFRNLVTMTTSTPISDNTCTN
Vps15_Ddis LHMIQKDPDQRYTPEK-YISKW-NTVFPQYF--SFA-HQFIPELMR---L----------
15015_Tthe ------TPYPLIPCRDESLQ--GYLCLDSSKV-GDSD-NLFSLTYNPDNI---EENQ---
VPS15_Spur KHMLQKDPSKRMSAEQ-YLVKGRGTAFPEFFY-TFL-KVYMGEFAGVPIY----------
CC1G_08691_Ccin KEMIHLDPTARPTFDS-LLHTSRGTVFPETFY-SFL-HNYISTLNEPSPSTYSSTSSATT
AqueK216_Aque RHMIQFKASDRRRPEQ-YLTMFKGLVFPEYFY-TFL-HDYFKSFTTATQL----------
VPS15-1_Smoe LQMIHVVPESRLSCDD-YLETWAYDVFPSYFS-PAL-HNLFSCLTRTMDL----------
VPS15-2_Smoe LQMIHIVPESRLSCDD-YLETWAYDVFPSYFS-PAL-HNLFSCLTRTMDL----------
GK073_Glam HAMINPIPSQRIDLST-L--QIRSIFTPEELFASDIILCFLKFFNP---L----------
. :
PIK3R4_Hsap ----------------------------------------SADERIL-------------
PIK3R4_Mmus ----------------------------------------SADERIL-------------
CG9746_Dmel ----------------------------------------SPDDKIQ-------------
ZK930.1_Cele --------------------------STDDFSQALEFSYLEPDDVIT-------------
VPS15_Scer -------------------------STL-------EDNVKLLDETTE-------------
Vps15_Ddis ----------------------------------------ENDDRVM-------------
15015_Tthe ---------------------------------------------FSI--MF--GICD--
VPS15_Spur ----------------------------------------PADEKIA-------------
CC1G_08691_Ccin PGSTLPTGSMSVLRPHAPHSAPGSEPTP-------ETLANDSDHRME-------------
AqueK216_Aque ----------------------------------------TPDQCIK-------------
VPS15-1_Smoe ----------------------------------------ESDSRVNL--RFFLRSSSLF
VPS15-2_Smoe ----------------------------------------ESDSRVNL--RFFLRSCSLF
GK073_Glam ----------------------------------------NLDDVVHVGATLFDGICDMY
PIK3R4_Hsap ----------VIRKDLGNIIH---------------------------------------
PIK3R4_Mmus ----------VIRKDLGNIIH---------------------------------------
CG9746_Dmel ----------CLHKDIGHCIK---------------------------------------
ZK930.1_Cele ----------KLKREKQLWWA---------------------------------------
VPS15_Scer ----------KIYRDFSQICH---------------------------------------
Vps15_Ddis ----------CISDKFDEIVDIFKNNSITNLFKSNLNQSTNSN--TI-GSFRVSTPSSPI
15015_Tthe --------------------------PNF-------------------------------
VPS15_Spur ----------RLRKDMGSIMQ---------------------------------------
CC1G_08691_Ccin ----------RIWEDYESIEP---------------------------------------
AqueK216_Aque ----------KLYGDIEAILA---------------------------------------
VPS15-1_Smoe SN-----QVALIQSSFSEIRSLMIRDAKDKSFS--------AD--CLDKELRITSPSPPL
VPS15-2_Smoe SN-----QVALIQSSFSEIRSLMIRDAKDKSFS--------AD--CLDKELRITSPSPPL
GK073_Glam LNSSSSQKAALTKCYFCDIHHRFQFEQQQQQ-P--------DDQHASKKASTMARASSTI
PIK3R4_Hsap ------------------------------------------------------------
PIK3R4_Mmus ------------------------------------------------------------
CG9746_Dmel ------------------------------------------------------------
ZK930.1_Cele ------------------------------------------------------------
VPS15_Scer ------------------------------------------------------------
Vps15_Ddis LISNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNQTTTTTTNTNINTTQQQQQQQQQQ
15015_Tthe ------------------------------------------------------------
VPS15_Spur ------------------------------------------------------------
CC1G_08691_Ccin ------------------------------------------------------------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe Q-----------------------------------------------------------
VPS15-2_Smoe Q-----------------------------------------------------------
GK073_Glam N-----------------------------------------------------------
PIK3R4_Hsap -------------------N-------LCGH-D-L-PEKAE-------------------
PIK3R4_Mmus -------------------N-------LCGH-D-L-PEKAE-------------------
CG9746_Dmel -------------------V-------LTQAQD-LTPEEEE-------------------
ZK930.1_Cele -------------------------------------RLSE-------------------
VPS15_Scer -------------------C-------LDFP-L-I-KDGGEIGSDPPILESYKIEIEISR
Vps15_Ddis QQQLQRPLSKLDDIGKNIAN-------IIYKTEQFVKESDE-----------------FD
15015_Tthe ----------------------------I-------------------------------
VPS15_Spur -------------------T-------LVAN-M-E-DGENN-------------------
CC1G_08691_Ccin -------------------Y-------LCP--E--PSEDRT-------------------
AqueK216_Aque -------------------N-------LFL--N---ST----------------------
VPS15-1_Smoe -------------------RKSRSSHAQTQH-D-L-------------------------
VPS15-2_Smoe -------------------RKSRSSHAQTQH-D-L-------------------------
GK073_Glam -------------------LGAQSSANITRF-D-L-PQDKK-------------------
PIK3R4_Hsap -----------------------------------------GE-----------------
PIK3R4_Mmus -----------------------------------------GE-----------------
CG9746_Dmel -----------------------------------------KEEKKDPT-LCARLP----
ZK930.1_Cele -----------------------------------------ND-----------------
VPS15_Scer FLNT--------NLY---FPQNYHLVLQQF-----------------TKVSEKIKS----
Vps15_Ddis KTDITNIKELNIQTTPTINTSTINRVIQTSKT--NTNLDTINENSNNNIGVNRKKV----
15015_Tthe ---------------------------------------------QS------------P
VPS15_Spur -----------------------------------------QR-----------------
CC1G_08691_Ccin -MDV--------NID---YTSNVQAVFKPFQDVIPVELHIPNRDSKLRTHAGRRAA----
AqueK216_Aque --------------------------------------------------KQDRET----
VPS15-1_Smoe -------------------LTDINLLLKDSKS-----------S-IQHTKHQKSKV----
VPS15-2_Smoe -------------------LTDINLLLKESKS-----------S-IQQTKHQKSKA----
GK073_Glam -----------------------------------------HQ---------AKKPIEMP
PIK3R4_Hsap --------------PKENGLVILVSVITSCLQTLKYCDSKLAAL-ELILHLAPRLSVEIL
PIK3R4_Mmus --------------SRASGLVVLVSVITSCLQTLKSCDSKLAAL-ELILHLAPRLSVEIL
CG9746_Dmel --------------PEHDGLILIITVVTSCIRGLKQSNTKIAAL-ELLQKLSKYTTSETI
ZK930.1_Cele --------------ESKSFAFLFVSLITANLRALRTIQGKTDAI-RMLVELSTISDSSVA
VPS15_Scer --------------VKEECALLFISYLSHSIRSIVSTATKLKNL-ELLAVFAQFVSDENK
Vps15_Ddis --------------TVVEGLDLFLSVIYTAVKHCQFPSTKVKCVGSLLVRLAEMLDDECR
15015_Tthe Y-----------------------------------------------------------
VPS15_Spur --------------HSNNGLVIVLSLVTSCLRSLKFCVSRLGAL-DIMLMIGKHLPDDII
CC1G_08691_Ccin --------------LEDGPALIILASVTSNIRNCKLPSSKVRAL-DVFLALSCHLTDEAK
AqueK216_Aque --------------GYGDVLVIVLSAITSNLRVAQFAGSKLQAI-EMMRTIANYVSDCSI
VPS15-1_Smoe --------------PTHEGMVLIASALCACLRHVKLPFARRAAV-QLLYNASVLCDDDAR
VPS15-2_Smoe --------------PTHEGMVLIASALCACLRHVKLPFARRAAV-QLLYNASVLCDDDAR
GK073_Glam YLCTTNMEIPFKIIEQLDGTVLRSLATCDCVHRI-LKEGRTSEVS-------------WN
PIK3R4_Hsap LDRITPYLLHFSNDS-VPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIA--HLA
PIK3R4_Mmus LDRITPYLLHFSNDS-VPRVRAEALRTLTKVLALVQEVPRNDVNIYPEYILPGIA--HLA
CG9746_Dmel LDRILPYILHLAQKS-PAKVQVQAIETLTACLGMVKDIPRSDANVFPEYILPSIT--DLA
ZK930.1_Cele IDRILPYFVHLWMDP-ETQVRATAVTAVAELLAPIQPKTYEESLVFVDYLFPHLN--SMS
VPS15_Scer IDRVVPYFVCCFEDS-DQDVQALSLLTLIQVLTSVRKLNQLNENIFVDYLLPRLK--RLL
Vps15_Ddis LQKIVPYIMSMISPEQPTLVRVEALRSLAKVLEMVQTFPPSESSIFGQYILPSLS--QLS
15015_Tthe ------------------------------------------------------------
VPS15_Spur LDRIIPCILHFVHDP-FPRVRAEAIRTITQTLMLVKSVPRGDANIFPDYILPNLS--NIA
CC1G_08691_Ccin LDRMVPYIVELLHDD-SALVRSAALRTLVQVLTLVSVITPSNVAIFPEYIIPNIK--HLV
AqueK216_Aque LERIVPFLHLLIKDK-WPSVRAEAIRTLSFCLSVIRKVPRSDFNLFPEYILPVIL--MVP
VPS15-1_Smoe LQLIVPFVAALLSDS-AAIVRCAALQTLCNVLSMVQTFSPSDAKVFPEYIFPLLS--MLP
VPS15-2_Smoe LQLIVPFVAALLSDS-AAIVRCAALQTLCNVLSMVQTFSPSDAKVFPEYIFPLLS--MLP
GK073_Glam CNVFGPFRRILASDTL----QAAMYHIAYSIMRLIQLDAFSISDTYKKGILTVCSYALFM
PIK3R4_Hsap QD--------------------------------------D-ATIVRLAYAENIALLAET
PIK3R4_Mmus QD--------------------------------------D-ATIVRLAYAENIALLAET
CG9746_Dmel SE--------------------------------------TSAVIVRVAFARNIAALAKS
ZK930.1_Cele NDS------------------------------------IDSPQHVLFAIATSLGQFADT
VPS15_Scer ISN------------------------------------RQNTNYLRIVFANCLSDLAII
Vps15_Ddis HE--------------------------------------STDEIIRIAFAEILPQLATT
15015_Tthe ------------------------------------------------------------
VPS15_Spur QD--------------------------------------P-IDMVRMVYAENIAVLAET
CC1G_08691_Ccin QD--------------------------------------P-EVSVRCTYAQCIVPIADT
AqueK216_Aque KD--------------------------------------I-DVQVRVALAESVAELALS
VPS15-1_Smoe DD--------------------------------------P-EESVRICYADCIHKIAGT
VPS15-2_Smoe DD--------------------------------------P-EESVRICYADCIHKIAGT
GK073_Glam DDSYVSHLIRMAYRVFRLRPTAVTLGGVAYLLNLLTTAYQDIHYIPLLV-MGEVFLPKNQ
PIK3R4_Hsap ALRFLELVQLKNLNMEN-DPNNEEIDEVTHP---------------------NGNY----
PIK3R4_Mmus ALRFLELVQLKTLNMEN-EPDNEEVDEATRP---------------------NGDY----
CG9746_Dmel AVYFLEETQRNAPN----D----------MP---------------------TPRY----
ZK930.1_Cele AYRFYMAGREIRQATMYD----DEVSTAGEQ---------------------Q-Q-----
VPS15_Scer INRFQEFTFAQHCNDNS-MDNNTEIME---S---------------------STKY----
Vps15_Ddis AKRFLEIAQHYRDPDSEG--IM-ESRKDRAK---------------------FRVY----
15015_Tthe ------------------------------------------------------------
VPS15_Spur ALRFLEMVQLDQ-NAAQ-SGETDGVQNPTQY---------------------QASY----
CC1G_08691_Ccin AVRYLEMGQALKAHGAFNLAAEGQDYEHAHY---------------------EISY----
AqueK216_Aque SHRFLELAQLQMNQEAAG--DEPSGVQY-QI---------------------YGTY----
VPS15-1_Smoe AYRFLVSQSS--------EGGSEELNEKS-R---------------------SAGF----
VPS15-2_Smoe AYRFLVSQSS--------EGGGEELNEKS-R---------------------SAGF----
GK073_Glam HDRFLEGVEIARHQLLD----VESLDEKAFESLANIFLYTAGSSSTTYPYLINHSYVIQL
PIK3R4_Hsap --------------DTELQA-------------LHEM--------VQQKVVTLLSD--PE
PIK3R4_Mmus --------------DTELQA-------------LHEM--------VQQKVVTLLSD--PE
CG9746_Dmel --------------EAELNA-------------LHDI--------VRQAVLSLLTD--SQ
ZK930.1_Cele --------------NDDAGA-------------LLHG--------VSA-MFSALCS--KE
VPS15_Scer --------------SAK----------------LIQS--------VEDLTVSFLTD--ND
Vps15_Ddis --------------DSDLQE-------------VQDQ--------FFNKVSDLLTK-DSC
15015_Tthe -----------------------------------------------------TCE--DE
VPS15_Spur --------------DDELQN-------------LHGM--------IQQKVVTLLSD--PE
CC1G_08691_Ccin --------------DASMQE-------------LQNH--------IQAHLAALLMD--PS
AqueK216_Aque --------------DNELHQ-------------LHET--------FQSIVVHLLSD--ND
VPS15-1_Smoe --------------TTELAQ-------------LRET--------IGRIIHDLVMGQKQT
VPS15-2_Smoe --------------TTELAQ-------------LRET--------IGRIIHDLVMGQKQT
GK073_Glam FPLLLASVARLSGGDPALKVIINAILLRNKTSLLYNILRSTSITPIILSSIRLL--SD--
PIK3R4_Hsap NIVKQTLMEN--GITRLC-VFFGRQKANDV------------------------------
PIK3R4_Mmus NIVKQTLMES--GITRLC-VFFGRQKANDV------------------------------
CG9746_Dmel PVVKQTLMES--GICDLC-AFFGKEKANDV------------------------------
ZK930.1_Cele PMVKRCLVES-KSLILLY-HFFIKIGNDDT------------------------------
VPS15_Scer TYVKMALLQN---ILPLC-KFFGRERTNDI------------------------------
Vps15_Ddis NTLKKIILSD---IYRLC-VFFGRQKTNES------------------------------
15015_Tthe QVVRNTLISYSTQITARI-SFYTKFHLQKT------------------------------
VPS15_Spur NIVKRTLLEN--GITRLC-VFFGRQKANDV------------------------------
CC1G_08691_Ccin SVVKRAVLHN---ISSLC-VFLGRQKTNDV------------------------------
AqueK216_Aque SNVKRAFLTH--SAGKLC-TFFGAQKAKEV------------------------------
VPS15-1_Smoe PTIRRALLEH---IAPLC-EFFGKKQCNDF------------------------------
VPS15-2_Smoe PTIRRALLEH---IAPLC-EFFGKKQCNDF------------------------------
GK073_Glam NIVLISSLLP-G-ILPLYLDFLGRTDLRKITHFCLGDAIASIFGGCLDQLEPSCKHITSL
: : * .
PIK3R4_Hsap ---------------LLSHMITFLNDKN---DWHLRGAFFDSIVGVAAYVGWQSS-SILK
PIK3R4_Mmus ---------------LLSHMITFLNDKN---DWHLRGAFFDSIVGVAAYVGWQSS-SILK
CG9746_Dmel ---------------ILSHIMTFLNDE----DKNLRGAFYDNIAGVAGYVGWQAS-DILV
ZK930.1_Cele ---------------LLRFLCTFLNAKT---EWRLRAAFFDSLP-VCV---QKRS-EGMV
VPS15_Scer ---------------ILSHLITYLNDK----DPALRVSLIQTISGISILLGTVTLEQYIL
Vps15_Ddis ---------------VLPLIITFLNDR----DWQLRCAFFENIVAVCTVVGAGSLESFIY
15015_Tthe ---------------DLTQQQGFIIQNS---DYDTY------FSGFARRDIFSSQ-QLIK
VPS15_Spur ---------------LLSHMITFLNDKE---DWHLRGSFFDSIVGVAAYVGWQSS-FILK
CC1G_08691_Ccin ---------------LLSHMITYLNDR----DWLLRYSFFESIVDVAACAGGRSLEEYIL
AqueK216_Aque ---------------ILSHMITFLNDKS---NWELHIAFFEAIVDVVSQIVIR-------
VPS15-1_Smoe ---------------LLPVLPAFLNDR----DKQLRALFFEQIVHVCIFVGEVSSEAYLL
VPS15-2_Smoe ---------------LLPVLPAFLNDR----DKQLRALFFEQIVHVCIFVGEVSSEAYLL
GK073_Glam KTTFQGARGAHSGKDIFFYVRIFLNNYHPLRDDKAAGTIFAAIL--------KS-ISIL-
: :: : :
PIK3R4_Hsap PLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHP---NLWIRYG
PIK3R4_Mmus PLLQQGLSDAEEFVIVKALNALTCMCQLGLLQKPHVYEFASDIAPFLCHP---NLWIRYG
CG9746_Dmel PLLQQGFTDREEFVIAKAIRAVTILIELGHIKKPAVTEIVQETACYLCHP---NLWVRHE
ZK930.1_Cele PLLQLGLQDGEEHVVVRALGCIHILIKNENLDKMSVKKLLDDVLPFLVHP---NDWIRST
VPS15_Scer PLLIQTITDSEELVVISVLQSLKSLFKTGLIRKKYYIDISKTTSPLLLHP---NNWIRQF
Vps15_Ddis PCILLALTDEEEFVTEKALSSLSELCSLGLLRKPILLELLVKTSPMLLHP---NNWIRYG
15015_Tthe SQLQMNVLGALEFFLGSESISLN-------IQFP---QFTSLLAQFTSVF---------N
VPS15_Spur PLLQQGLTDHEEQVICKALKSVTGLVQLGLLQKPALLEMAYELVPYVCHP---NLWIRQA
CC1G_08691_Ccin PLMIQALSGA--------------------------------------------------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe PYLEQALSNVEEPVIVNALECLAALCVYKLLKKRVLLKTVERASPLLCHP---SQWVRRA
VPS15-2_Smoe PYLEQALSNVEEPVIVNALECLAALCVYKLLKKRVLLKTVERASPLLCHP---SQWVRRA
GK073_Glam PLDLQS---TCIYLFCKS------------VYIPS-VQLSDDLGRSLWSPNNQNIWLLLN
PIK3R4_Hsap AVGFI--------------------------------------TVVARQISTA-------
PIK3R4_Mmus AVGFI--------------------------------------TVVAHQISTA-------
CG9746_Dmel ICGMI--------------------------------------ATTARNLSAI-------
ZK930.1_Cele VCDIL--------------------------------------LAIDCQWHNA-------
VPS15_Scer TLMII--------------------------------------IEIINKLSKA-------
Vps15_Ddis VVSLI--------------------------------------VKICQSLSKA-------
15015_Tthe SLLFL--------------------------------------GIISKFFAES-------
VPS15_Spur TVGFI--------------------------------------AAIARSLNIA-------
CC1G_08691_Ccin -AAFI--------------------------------------TSAAQQLPAS-------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe AITLV--------------------------------------AASGSNLSVA-------
VPS15-2_Smoe AITLV--------------------------------------AASGSNLSGA-------
GK073_Glam AIKTVIEKKDSQDALLFSFFLNDNLNQYVNIRLAGALMKILTLTVRSFDLSTQDSSQYAG
PIK3R4_Hsap ----------------DVYCKLMP-YLDPYITQ---------PI----------------
PIK3R4_Mmus ----------------DVYCKLMP-YLDPYITQ---------PV----------------
CG9746_Dmel ----------------DVQCKIMP-AIGAFLKA---------PL----------------
ZK930.1_Cele ----------------EVHVKLIP-LVSPFVEES------KRGV----------------
VPS15_Scer ----------------EVYCILYP-IIRPFFEF---------DV----------------
Vps15_Ddis ----------------DVYCYVKP-KLSPFLVNLNGNGNGNAEI----------------
15015_Tthe ----------------EIFSQVAEMQLKIYFKK---------SA----------------
VPS15_Spur ----------------DVHCNLTP-LLLPFLKK---------PI----------------
CC1G_08691_Ccin ----------------DIWCIVYP-SLRHFLKS---------DI----------------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ----------------DAHAYLIP-LLLPFLRR---------EP----------------
VPS15-2_Smoe ----------------DAHAYLIP-LLLPFLRR---------EP----------------
GK073_Glam VLIKRHVKQSVNDRRHQVMHIILP-KLSPVAPQIVEN------LHLFYPDLHKYSSFSDD
PIK3R4_Hsap ------------------------------------------------------------
PIK3R4_Mmus ------------------------------------------------------------
CG9746_Dmel ------------------------------------------------------------
ZK930.1_Cele ------------------------------------------------------------
VPS15_Scer ------------------------------------------------------------
Vps15_Ddis ------------------------------------------------------------
15015_Tthe ------------------------------------------------------------
VPS15_Spur ------------------------------------------------------------
CC1G_08691_Ccin ------------------------------------------------------------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ------------------------------------------------------------
VPS15-2_Smoe ------------------------------------------------------------
GK073_Glam VSTHHDPDYDIQHEVLRKIQENYALIERLTFLTIDDLTNPQRYLFMLQEIVHAASTIIEN
PIK3R4_Hsap -----------IQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHLHM------RQK
PIK3R4_Mmus -----------IQIERKLVLLSVLKEPVSRSIFDYALRSKDIASLFRHLHM------RQK
CG9746_Dmel -----------IQVEKPHILLDCVHPPVPRQIFDSVLRFQDIHHFIRALEA------RSR
ZK930.1_Cele -----------LTLKSKPVLMSQLVDPIPRTTFNQIIDQSLENTKQITML--L----EIH
VPS15_Scer ------------EFNF-KSMISCCKQPVSRSVYNLLCSWSVRASKS--LFW--KKIITNH
Vps15_Ddis -----------SDTITESNLIQLLDSPISRESFNKIVKFIARNRIN--LSSSINSILAND
15015_Tthe -----------LFILK--------------------------------------------
VPS15_Spur -----------IQIDKEAIIMSVLKCPVSRAVYDYILRSPIIIDFFDNLTD------RQL
CC1G_08691_Ccin -----------GEINT-SSLLRAMKPPLPRQILDSSVQWAMKADRS--VFW------SRP
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe -----------LSISSEAALLACLKPPVSRDVFQRVLSNVMLTSNSTEAAT------ERP
VPS15-2_Smoe -----------LSISSEAALLACLKPPVSRDVFQRVLSNVMLTSNSTEAAT------ERP
GK073_Glam LTTFVQQIAISTSIN-TDNLQEKHEENLPLYLLVKDMPTAPDAN----------------
PIK3R4_Hsap ------------KRN------GS-------------------------LPDCP-------
PIK3R4_Mmus ------------KRN------GS-------------------------LLDCP-------
CG9746_Dmel ------------VRSQ-T-RQGA-------------------------LPQYE-------
ZK930.1_Cele ------------FQT------GK-------------------------PFEAG-------
VPS15_Scer VDSFGNNRIEFITKNYSSKNYGFN------------------------KRDTKSSSSLKG
Vps15_Ddis NDNFNGESF---NSNG--SGGGGNPNLVSSTGGSNRRLRALSNKFFVPNILSASNSSIN-
15015_Tthe ----------------------------------------------------Q-------
VPS15_Spur ------------IRNL-CIRPGH-------------------------KPEYN-------
CC1G_08691_Ccin ------------------RRGGS-------------------------KTESPRESVIS-
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ------------KPR------QR-------------------------VPDAT-------
VPS15-2_Smoe ------------KPR------QR-------------------------VPDAT-------
GK073_Glam ------------------------------------------------------------
PIK3R4_Hsap ------------------------------------------------------------
PIK3R4_Mmus ------------------------------------------------------------
CG9746_Dmel ------------------------------------------------------------
ZK930.1_Cele ------------------------------------------------------------
VPS15_Scer IKTSSTVYSHDNKE----------------------------------------------
Vps15_Ddis S-TSGDI---GSLL----------------------------------------------
15015_Tthe ------I---GQGENIQRDQKQGLEKLLSYIKNADFKNLGKKMKISFFRKIMYVFMGNIK
VPS15_Spur ------------------------------------------------------------
CC1G_08691_Ccin V-RKAGT---GNLA----------------------------------------------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ------------------------------------------------------------
VPS15-2_Smoe ------------------------------------------------------------
GK073_Glam ------------------------------------------------------------
PIK3R4_Hsap PPEDPAI-AQLLKKLLSQGMTE----EEEDKLLALKDFMMKSNKAKANIV----------
PIK3R4_Mmus PPEDPTI-AQLLKKLLSQGMTE----EEEDKLLALKDFMMKSNRAKANAV----------
CG9746_Dmel E-MGQTL-RNLFRRLSSEGLTD----LIEMQLLAMNPFLISMKHKAL--Q----------
ZK930.1_Cele AGWFNTI-FPKIKTETKAGVVEH-----NDLKAALEAR-KRLTASVYSFR----------
VPS15_Scer IPLTAED-INWIDKFHIIGLTE----KDIWKIVALRGYVIRTARVMAANP----------
Vps15_Ddis SQSTEES-LAFLRQMTSIGISD----SDQNKIIKCFDYLQSKKCKDLESANNSEGNVIVI
15015_Tthe NEKKETIQEKLFKQIVSQSNKALNIFEIQKELLQMKI-MMRLI-----------------
VPS15_Spur ELEIGQM-AQLLRKLQSQGMTE----EDEDKLLFLREIMLKQSKAKIGMG----------
CC1G_08691_Ccin KNRSEED-EVHINKLQQLGLTS----SDESKLLAMRDYILKLANATASFS----------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe FGHGR---TPMMKIPLQRNVPDF---EDGEKLKAMEGYIRNLSSTMHS-W----------
VPS15-2_Smoe FGHGR---TPMMKIPLQRNVPDF---EDGEKLKAMEGYIRNLSSTMHS-W----------
GK073_Glam ----PS----------FSGMHA----RTQDDILHSSKELSR-------------------
PIK3R4_Hsap --------------------D-----QS------------HLHDSSQKGVID---LAALG
PIK3R4_Mmus --------------------D-----QS------------HLHDSSQKGVID---LAALG
CG9746_Dmel --------------------D-----LDDT--------------ASGNGRIV---VSRKQ
ZK930.1_Cele --------------------K-----LFERMAETRNTAGMEIYLTRQLGTID---LSSIA
VPS15_Scer --------------------D-----FPYN--------NSNYRPLVQNSPPN---LNLTN
Vps15_Ddis RTNGTTIISSSNNSNNNTLSSST---TSSN--------STTPTN----STVN-----LHS
15015_Tthe -----------------------------------------------LSVEQ---YAAIQ
VPS15_Spur --------------------D-----LSNQ--------SSSPHDPFTPGQVN---LSVYP
CC1G_08691_Ccin -------------------SR-----LSYE--------PDTGKNLKVTGDLE---LQKLG
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe --------------------D-----LENP----------EKMDASATGAGF---FSNFD
VPS15-2_Smoe --------------------D-----LENP----------EKMDASATGAGF---FSNFD
GK073_Glam ----------ANFSASQRMDFRSLTSLND---------VSIWTDASVSRVAEELVYAGHG
PIK3R4_Hsap ITG-RQVDLVKT-----------------KQEPDDKRARKH-VKQ---------------
PIK3R4_Mmus ITG-RQVDLVKT-----------------KQEPDEKRARKH-VKQ---------------
CG9746_Dmel ---------VAC-----------------HEYPLADKAS-K-MPL---------------
ZK930.1_Cele HSR-----------------------VRRKEF----------------------------
VPS15_Scer IMP-RNIFFDVEFAEEST-SEGQDSNLENQQIYKYDESEKDSNKL---------------
Vps15_Ddis VLN-NTTIIQQQ--QQQLQQTIT------Q---------QS-ITQQQQQQQQQ-------
15015_Tthe LC-GSKLPICND-----------------KQK----------------------------
VPS15_Spur AIQKNHADLIKP--PDLR-SEVT------DKAQTKKSKKKQ-SAI---------------
CC1G_08691_Ccin VVP-QTVFLKQR--QDSG-SRMT------I-----PSSRRS-ISSRTSAMSPR-------
AqueK216_Aque ---------------------------------------KE-L-----------------
VPS15-1_Smoe VA---------T-----------------DSIPLYSRPPTD-RRL---------------
VPS15-2_Smoe VA---------T-----------------DSIPLYSRPPTD-RRL---------------
GK073_Glam SS-GSRHLIVSN--EYQV------------LLKDGERARHV-VEL-------FYGPVGDA
PIK3R4_Hsap ------------------------------------------------------------
PIK3R4_Mmus ------------------------------------------------------------
CG9746_Dmel ------------------------------------------------------------
ZK930.1_Cele ------------------------------------------------------------
VPS15_Scer ------------------------------------------------------------
Vps15_Ddis --Q---------------------------------------------------------
15015_Tthe ------------------------------------------------------------
VPS15_Spur ------------------------------------------------------------
CC1G_08691_Ccin --F---------------------------------------------------------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ------------------------------------------------------------
VPS15-2_Smoe ------------------------------------------------------------
GK073_Glam KDRMKEILFGKDQEASIEDTSVQYSTYSLIPEISTLPDESVLHSTLFSSLLSACKPFLIT
PIK3R4_Hsap ---------------------------------------DSNVNEEWKSMFG--SL----
PIK3R4_Mmus ---------------------------------------DSNVNEEWKSMFG--SL----
CG9746_Dmel ---------------------------------------DNRSSEG--------------
ZK930.1_Cele ----------------------------------------TYGGDE-------------S
VPS15_Scer ---------------------------------------NINGSKQLSTV----------
Vps15_Ddis --------QVSGGITTGGT------TTTTLGR-SSSPQLTGLNP------SI--LS----
15015_Tthe ------------------------------------------------------------
VPS15_Spur ---------------------------------------DPAMNEEWRSMFG--TAADTK
CC1G_08691_Ccin --------PRPPSIDHGSV------G-TGAPFEDLRRRLASINNSVSSLSPN--QPKDAR
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ---------------------------------------DNSGNEEWSRIYR--QPMDTL
VPS15-2_Smoe ---------------------------------------DNSGNEEWSRIYR--QPMDTL
GK073_Glam DASASIRNMLRPGILSGYLCKSLNMQSVVLAR-RWLPFL------------RESSL----
PIK3R4_Hsap -----------------------DPPNMP-------------------------------
PIK3R4_Mmus -----------------------EPPNIP-------------------------------
CG9746_Dmel ----------------------------P-------------------------------
ZK930.1_Cele A---------------------------M----------------------S--------
VPS15_Scer ------------------------------------------------------------
Vps15_Ddis -N---------------------SNNIQL----------------------S--------
15015_Tthe ------------------------------------------------------------
VPS15_Spur PIKASQQQTSINTPPLHPSGGDLPPPHAP-------------------------------
CC1G_08691_Ccin SV---------------------SSPLAP----------------------S--------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe A-----------------------------------------------------------
VPS15-2_Smoe A-----------------------------------------------------------
GK073_Glam -----------------------PPSALPKLLNTLLNNLLIISPGTHSLPTSNSLIQHVC
PIK3R4_Hsap ------------------QALP------KGSDQEVI----Q----T----GKP---PRSE
PIK3R4_Mmus ------------------QALP------KTSDHEVV----Q----P----GKP---PRSE
CG9746_Dmel ------------------TLAS------PASDAAITPL--GAGGLA----GSP---ASGA
ZK930.1_Cele ------SNSKHLTAINIPNHST------ERRDTLL-----LAGEVV----IEE---ER--
VPS15_Scer ------------MD--------------------------INGSLI--------------
Vps15_Ddis ------SSVVDVTKLP--NSIPIRMVKIRGGDQSLNNSTVSLGSVAGGNIITP---STSL
15015_Tthe -----------------------------EQDQEVIE--------E----SQI---SN--
VPS15_Spur ------------------VQRS------ASKAAPQK----PPGGQD----QTP---PSSA
CC1G_08691_Ccin ------SSSISVASAT--APSPVA-----------------AERER----DRP---PSPT
AqueK216_Aque --------------------------------------------------SSP---PHTQ
VPS15-1_Smoe ---------------------Y------SQSDMMQK----------------S---MMQK
VPS15-2_Smoe ---------------------Y------SQSDMMQK----------------S---MMQK
GK073_Glam KQFKVEDM---LSDK--PTEIGREFITIPGLQHDLKNTSV------------IITYQNPL
PIK3R4_Hsap ------------------------------------------------------------
PIK3R4_Mmus ------------------------------------------------------------
CG9746_Dmel ------------------------------------------------------------
ZK930.1_Cele ------------------------------------------------------------
VPS15_Scer ------------------------------------------------------------
Vps15_Ddis S---------------------------------NSNTMVGNNNNNSYNTS---------
15015_Tthe ------------------------------------------------------------
VPS15_Spur Q---------------------------------AQ------------------------
CC1G_08691_Ccin E---------------------------------SV--------VSNAN-S---------
AqueK216_Aque S---------------------------------Q-------------------------
VPS15-1_Smoe ------------------------------------------------------------
VPS15-2_Smoe ------------------------------------------------------------
GK073_Glam AYSRHELVKYIVAETQVALDFISMRANPRGDLIMNSKTIQGMQSNNPLYTHYSNLIRAAS
PIK3R4_Hsap ------------------------------------------------------------
PIK3R4_Mmus ------------------------------------------------------------
CG9746_Dmel ------------------------------------------------------------
ZK930.1_Cele ------------------------------------------------------------
VPS15_Scer ------------------------------------------------------------
Vps15_Ddis -----------TSSSPLS-----------------------SSVLNSSVGMNNL------
15015_Tthe ------------------------------------------------------------
VPS15_Spur ---------------P--------------------------------------QPQGQL
CC1G_08691_Ccin -----------VSLRPASRLQVGSVEGSKAAPAVGSSKTVATGLLDAHSHIGSPDPS---
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ------------------------------------------------------------
VPS15-2_Smoe ------------------------------------------------------------
GK073_Glam DLIINASITHHVNKTP--------------------------------------------
PIK3R4_Hsap ----------SSAGICV----------------------------------------PLS
PIK3R4_Mmus ----------SSAGICV----------------------------------------PLS
CG9746_Dmel ----------VVLG--V----------------------------------------PTA
ZK930.1_Cele ----------TVTN--T----------------------------------------PA-
VPS15_Scer ------------------------------------------------------------
Vps15_Ddis -----------------TNSNANSINNSSGINNNNSNNNSVNSNNYNNMNNNTMNN----
15015_Tthe ----------QIVS----------------------------------------------
VPS15_Spur KQQQQAAQQQAQQGVDAK----------AATQRQNHKTDAAQGGGKGQINKGLMANEPIR
CC1G_08691_Ccin -----------------GR-----------------------------------------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ----------SIIA--I----------------------------------------PSK
VPS15-2_Smoe ----------SIIA--I----------------------------------------PSK
GK073_Glam ----------------------------------------------------------YR
PIK3R4_Hsap -------------------------------------------------------TSSQV
PIK3R4_Mmus -------------------------------------------------------TSPQV
CG9746_Dmel -------------------------------------------------------T---V
ZK930.1_Cele ------------------------------------------------------------
VPS15_Scer -------------------------------------------------------FKNKS
Vps15_Ddis --------------------------------------------------------SVNL
15015_Tthe ------------------------------------------------------------
VPS15_Spur -------------------------------------------------------MSQLQ
CC1G_08691_Ccin --------------------------------------------------------SSPL
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ------------------------------------------------------------
VPS15-2_Smoe ------------------------------------------------------------
GK073_Glam ALLPANSVSLNDIQGPLERIGTIQSKLAYDFVANDHVSMTSKNMTLPGCVQTRVSYNYAS
PIK3R4_Hsap PE-VTTVQNKKPVI-----------------------------PVL----------SSTI
PIK3R4_Mmus SE-AAHIPSKKPVI-----------------------------PVV----------SSTV
CG9746_Dmel SA-ATSLGEY--TM-----------------------------PER----------N---
ZK930.1_Cele ---------------------------------------------P----------YSPV
VPS15_Scer IA-TTTSNLKNVF--------------------------------------------VQL
Vps15_Ddis MN-SNQIGQQQQQN-----------------------------PNTVKIDLVSPSDLNVV
15015_Tthe ------------------------------------------------------------
VPS15_Spur AA-AEGIPVKKPVQ--------------------------------------------ES
CC1G_08691_Ccin SM-SATLRQHRPRV-----------------------------P-------------SLL
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe -----------------------------------------------------------F
VPS15-2_Smoe -----------------------------------------------------------F
GK073_Glam LKSFTYSAIGNMFIILDAKNYIHFYLNPVDEAIKFLAQRILLLSRTVKISMESSPEAHA-
PIK3R4_Hsap LPSTYQIRITT--CKTELQQLI------------------QQKREQCNAE----------
PIK3R4_Mmus LPSTYQIRITT--CKTELQQLI------------------QQKREQCNAE----------
CG9746_Dmel ---CWLERSSE--CRKDLESLT------------------AKIKSRYNVL----------
ZK930.1_Cele KNTTFDNQVNE--MLAHLNELHMRNVNCRPK-----R--------PLAAS----------
VPS15_Scer EPTSYHMHSPN--HGLKDNANV------KPE-----RKVVVSNSYEGDVE----------
Vps15_Ddis SK-KYYIRDPKMGLSTILK---------------------VETNVECSIKVPLPLPDLGS
15015_Tthe ---------------------V------------------DQKLEKSNEI----------
VPS15_Spur KPVASHIQVSS--CHLNLRSLV------------------TRKRDQYAMD----------
CC1G_08691_Ccin PISTYDGQEPG--ISNLLENLY------------------LDNNRELQQDFGPPVHE---
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe TGSIY-GRTPS--HET---------------------------STEPAFD----------
VPS15-2_Smoe TGSIY-GRTPS--HET---------------------------STEPAFD----------
GK073_Glam DHYSV-LAGLPQG--LPQLQN-------EPKHQKITAPVLTSSPALESLE----------
PIK3R4_Hsap ------------------------------------------------------------
PIK3R4_Mmus ------------------------------------------------------------
CG9746_Dmel ------------------------------------------------------------
ZK930.1_Cele ------------------------------------------------------------
VPS15_Scer ------------------------------------------------------------
Vps15_Ddis TDSVLGGGLLSSGGVGGGVGGTGGGNINGVSGINGNVGGGGGGVGVGTVGSGGNGSIGGG
15015_Tthe ------------------------------------------------------------
VPS15_Spur ------------------------------------------------------------
CC1G_08691_Ccin ------------------------------------------------------------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ------------------------------------------------------------
VPS15-2_Smoe ------------------------------------------------------------
GK073_Glam ------------------------------------------------------------
PIK3R4_Hsap --------------------------RIAKQMME-------------NAEWESKPPPPGW
PIK3R4_Mmus --------------------------RIAKQMME-------------NAEWESKPPPPGW
CG9746_Dmel --------------------------AISQRCSY-------------DK--LVTPYPPGW
ZK930.1_Cele --------------------------ASHPVLSA-------------SPSAGSLGSSSNN
VPS15_Scer --------------------------SIEKFLSTFKILPPLRDYKEFGPIQEIVRSPNMG
Vps15_Ddis NSGINNGSGGGGVNSGGNSGINSGSTNSSGSLYG-------------NGNGLDNLPNSTW
15015_Tthe --------------------------KEDKQNFE-------------D------------
VPS15_Spur --------------------------IMRKMLIH-------------DTTFNAKAPQSNW
CC1G_08691_Ccin -------------------------GPIRRRNTS-------------R-HPFGTRDITNK
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe --------------------------AFNKFL------------------KSSAGSDSRW
VPS15-2_Smoe --------------------------AFNKFL------------------KSSASSDSRW
GK073_Glam --------------------------SIMEYLSTGVL----------------TLPLATF
PIK3R4_Hsap RPKGLLVAHLHEHK--------SAVNRIRV-SD-EHSLFATCSNDGTVKIWNSQKMEGK-
PIK3R4_Mmus RPKGLLVAHLHEHK--------SAVNRIRV-SD-EHLLFATCSNDGTVKIWNSQKMEGK-
CG9746_Dmel RMTGTLVAHLHEHS--------ESVIKLASLRP-HGSLFASGSIDGTVRLWDCSKLNGN-
ZK930.1_Cele NVKGIIITHLHEHS--------GKITKLCA-NR-ESDLFLSGSTDGTVKVWKTRSVLGEG
VPS15_Scer NLRGKLIATLMENEP-------NSITSSAV-SPGETPYLITGSDQGVIKIWNLKEIIV--
Vps15_Ddis RPMGILVSHFFEHK--------AAVNEIQV-SS-DNLFFATASNDGTVKIWDCQRMEK--
15015_Tthe ------------------------------------------------------------
VPS15_Spur KPRGLLIAHLHEHK--------GAVNRLQV-SY-DHTLFSTCSDDGTVKVWDCTKLIGK-
CC1G_08691_Ccin RLEASLISNLTSHS--------EAITGIAV-SP-DHAFFVTASDDKTVKVWDTARLER--
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe RPRGVLVSHLHEHQ--------RAVNQVAV-SS-DNSFFTSASDDGTVKVWDCRRLER--
VPS15-2_Smoe RPRGVLVSHLHEHQ--------RAVNQVAV-SS-DNSFFTSASDDGTVKVWDCRRLER--
GK073_Glam HIPGVSILHIFVDPCGIPILGGGKATEKKSV-RHEFLALNIVTDSCVVKLLVDPDMLIQQ
PIK3R4_Hsap T-----------TTTRSIL-TYSR-IGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASK
PIK3R4_Mmus T-----------TTTRSIL-TYSR-IGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASK
CG9746_Dmel Q-----------GVNKSRQ-VYSA--NTPIYALAACDSGQSLAVGGKDGSMLMMRIDRN-
ZK930.1_Cele Y-----------GSARSED-TWIPTETSREKVNSVGWNDQFACSATNDGFVRWADVGQGS
VPS15_Scer G-----------EVYSSSL-TYDC--SSTVTQITMIPNFDAFAVSSKDGQIIVLKVNHYQ
Vps15_Ddis S-----------VTNRARQ-TYAQ-QEGRITSISICEKTHSIASASDKGSIHVFRVGISG
15015_Tthe ------------RTQNNIL-SFSR-EK-------------QESVRKFNGTVYPISIEQQI
VPS15_Spur A-----------NTNKSRQ-TYNR-QPGKIKTLTFCQSSHSIASGSDDGSIHVNRIEAS-
CC1G_08691_Ccin N-----------VTSKARH-TYNQ-HHARVKCVCIIEGTHCFASAAEDGSLHVVRVQLTQ
AqueK216_Aque -----------------------------------CQ-----------------------
VPS15-1_Smoe S-----------TSFRSKL-TYSFGQNERVLCLAMLSPDQQVAAASSAGEIRVLCVDYIA
VPS15-2_Smoe S-----------TSFRSKL-TYSFGQNERVLCLAMLSPDQQVAAASSGGEIRVLCVDYIA
GK073_Glam YTEAILVTDSNCNANRAGGVTFS-M-NDAVFSLSISGSGKSVELV-DFGMLHKTQLNGAL
PIK3R4_Hsap LP--------KSPKIH-----------PLQS-RILDQKEDG---CVVDMHHFNSGAQS--
PIK3R4_Mmus LP--------KSPKIH-----------PLQS-RILDQKEDG---CVVDMHHFNSGAQS--
CG9746_Dmel -----------SAKMT-----------LQQA-LNQNDHKDG---PVVDMHAYDQATQS--
ZK930.1_Cele ------------ARVA-----------T-Q--VRIP-DAEG---PPVYLHCNG----P--
VPS15_Scer QE--------SEVKFL-----------NCECIRKINLKNFGKNEYAVRMRAFVNEEKS--
Vps15_Ddis KQK------NGNIKYT-----------NLSTVKNITETTRG---NIVSVSHYSTNSSS--
15015_Tthe ------------------------------------------------------------
VPS15_Spur -----------PPRLA-----------PLDK-RQLNVSEEG---VPVDLAHFDTGPQS--
CC1G_08691_Ccin SAAGASSAAGSLPKYG-----------KLQVVREHRVESVG--EWITCMVHYKSDSTS--
AqueK216_Aque ------------------------------ITR---------------------------
VPS15-1_Smoe REG------NVPERYS-----------GISNVR-RTDAQEG---SVLALQAFG----G--
VPS15-2_Smoe REG------NVPERYS-----------GISNVR-RTDAQEG---SVLALQAFG----G--
GK073_Glam T-------E-NTIQYLLPYLTADQICTFLKAYHNDSVTEKS-SAPKV-THLYMHSTLSAS
PIK3R4_Hsap ----------------------------------------------------VLAYATVN
PIK3R4_Mmus ----------------------------------------------------VLAYATVN
CG9746_Dmel ----------------------------------------------------VIVYATLY
ZK930.1_Cele ----------------------------------------------------MAIVRTHH
VPS15_Scer ----------------------------------------------------LLVALTNL
Vps15_Ddis ----------------------------------------------------VVTYATTK
15015_Tthe ------------------------------------------------------------
VPS15_Spur ----------------------------------------------------ILVYATSQ
CC1G_08691_Ccin ----------------------------------------------------SLVYATTH
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ----------------------------------------------------MLLYSTQK
VPS15-2_Smoe ----------------------------------------------------MLLYSTQK
GK073_Glam LDHANGVELLLTRLRYKNQFPLNLKSAESQVYSVMPHRILTYYNCYLLSEIVAILSTTVV
PIK3R4_Hsap GSLVGWDLRS--------SSNAWTLKHDLKSGLI-TSFAVDI-HQCWLCIGTSSGT--MA
PIK3R4_Mmus GSLVGWDLRS--------SSNAWTLKHDLKSGLI-TSFAVDI-HQCWLCIGTSSGA--MA
CG9746_Dmel GGIVAWDTRM--------QHSAWRLQNELRHGVI-TTICADP-TGSWLATGTSGGK--HI
ZK930.1_Cele GVLYGIDLRVGASEGPLKRHDIWRKKFQESHGLV-TSSAIDPWQQSWMVIGNNSGQKNLV
VPS15_Scer SRVIIFDIRT--------LERLQIIENSPRHGAV-SSICIDE-ECCVLILGTTRGI--ID
Vps15_Ddis GGIHGWDLRS--------QQDAFNLVNDASLGLI-QAFLIDP-NRNWLVTGTSRGF--LT
15015_Tthe ------------------------------------------------------------
VPS15_Spur GYLVGWDLRS--------PTEAFRLRNQQRHGALVRRVRLHP-SQ---------------
CC1G_08691_Ccin SNIAILELRT--------MRVLQTMENPRHYGPI-TAMCMDK-RRAWLVVGTSTGV--LT
AqueK216_Aque -----------------------GVRNEEKSGTL--------------------------
VPS15-1_Smoe NGLHLWDFRE--------QRDAWLLKAKPEQGYV-SALAADP-SRHWLVSGTSRGV--LT
VPS15-2_Smoe NGLHLWDFRE--------QRDAWLLKAKPEQGYV-SALAADP-SRNWLVSGTSRGV--LT
GK073_Glam TCTALYDGTS--------GNRMYTL--PKEFGE-IQYACES-AS-GSIAVLTSMG--WLI
PIK3R4_Hsap CWDMRFQLPISSHCHPS------RARIRRLSMHPLY-----QSWVIAAVQ--------GN
PIK3R4_Mmus CWDMRFQLPISSHCHPS------RARIRRLSMHPLY-----QSWVIAAVQ--------GN
CG9746_Dmel CWDLRFRLPIAEIKHPA------DSWIRKVACHPTE-----PSYLISASQ--------SN
ZK930.1_Cele LYDLRFKEEVLRWESPHQNTQPNR-----VWANPVSRQECPEVF-VG-FS--------MH
VPS15_Scer IWDIRFNVLIRSWSFGD------HAPITHVEVCQFYG---KNSVIVVGGS--------SK
Vps15_Ddis CWDLRFGIPLYSVRVSN-------GRILKFAPYMLAKS-ASESWVYIST---------EQ
15015_Tthe ------------------------------------------------------------
VPS15_Spur -----------------------------------------QSLVISAVQ--------GN
CC1G_08691_Ccin LWDKRFGILLKSWQTAAATSSGKSCKVHQIAVHPTKG---RGKWIIVALETSKKGLASSR
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe LWDLRFQVQVYSWRLPSC------HPVE-AMCVPVGSS-LPRPFVYV-AA--------GR
VPS15-2_Smoe LWDLRFQVQVHSWQLPSC------HPVE-AMCVPVGSS-LPRPFVYV-AA--------GR
GK073_Glam LLEFRAGNLLDLWV----------------------------------------------
PIK3R4_Hsap N---EVSMWDMETG-DRRFTLWASS-APP---LSE--LQP----S---------------
PIK3R4_Mmus N---EVSMWDMETG-DRRLTLWASS-APP---LSE--LQP----S---------------
CG9746_Dmel N---EVSVWNIETG-QRQTVLWASP-VAA---LSS--ASP----S---------------
ZK930.1_Cele G---EISTYELSAQPLRKRVFWTGG-API---LSY--SAA----S---------------
VPS15_Scer T---FLTIWNFVKG-HCQYAFINSDEQPS---MEH--FLP----IEKGLEEL--NFCGI-
Vps15_Ddis D---NVIVFDLSNK-KTTRVFKRSYEQPP---QQQ-PQQP----QPPQQQQQQQSQMNRS
15015_Tthe ------------------------------------------------------------
VPS15_Spur N---EVSMWDMETG-ARRFTLWASP-HPP---LSQ--TQ---------------------
CC1G_08691_Ccin DSVTIIEVWDVEKS-VLVETFVVGTSSDRER-EREGSESP----GPHEVE-VEGVDANPS
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe N---EVAVWNVENG-NCQQILKSAVQSNGTSFV--ANLQPWGRRTGPKQQHQEASK----
VPS15-2_Smoe N---EVAVWNVENG-NCQQILKSGVQSNGTSFV--ANLQPWGRRTGPKQQHQEASK----
GK073_Glam ----------LAEK-QRYNVHRYSA-ILG---FN-GLLSPT------HSFTHEAEE----
PIK3R4_Hsap ------------------------------------------------------------
PIK3R4_Mmus ------------------------------------------------------------
CG9746_Dmel --------------------------------D---------------------------
ZK930.1_Cele --------------------------------N--------------------------D
VPS15_Scer ------------------------------------------------------------
Vps15_Ddis INMTSSTTTTTTSSYDFGTENLKTSSYSQLPSNPLVNSIVNNSNINNNNNNNDNSNNVTI
15015_Tthe ------------------------------------------------------------
VPS15_Spur ------------------------------------------------------------
CC1G_08691_Ccin --PAAA-IAAFVRSRQLQSENERRSSAR------------------------GSANEELV
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe --------------------------LS------------------------DYKVEELS
VPS15-2_Smoe --------------------------LS------------------------DYKVEELS
GK073_Glam --------------------------SA------------------------EAITE---
PIK3R4_Hsap --P-HSVHGIY--------------------------CSP-ADGNPILL-----------
PIK3R4_Mmus --P-HSVHGIY--------------------------CSP-ADGNPILL-----------
CG9746_Dmel --P-ATTCGIL--------------------------SGV-VDGSPFIL-----------
ZK930.1_Cele ARKQDS-LATRS-------------------------LCV-CEKTGVVY-----------
VPS15_Scer ----RSLNALS--------------------------TI-SVSNDKILL-----------
Vps15_Ddis FKPTPLVRALL----------------------------N-PPNCPFLI-----------
15015_Tthe ------------------------------------------------------------
VPS15_Spur ----HAIHALY--------------------------CIPSMEQTPCFL-----------
CC1G_08691_Ccin APPAPDVRAMVVGLDFGGYASAHRLEYGEFIPDGGGASSR-SSTKGFVV-----------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe DPP-PRIPGVRA-------------------------LLP-TTAGASVI-----------
VPS15-2_Smoe DPP-PRIPGVRA-------------------------LLP-TTAGASVI-----------
GK073_Glam STAKPSVR---R-------------------------YY-AITSTLFIVAYGSHVVIYEF
PIK3R4_Hsap -----------TAGSDMKIRFWDLAY-------------PERSYVVAGSTSSP-------
PIK3R4_Mmus -----------TAGSDMKIRFWDLVS-------------PERSYVVAGSTGSP-------
CG9746_Dmel -----------TGSSDQRIRYWDITN-------------PKNSSLKVPAANDNLA-----
ZK930.1_Cele -----------TGDTRGAIRKWNPTR-------------AVGCEIISAPPKGRTAYRTIF
VPS15_Scer -----------TDEATSSIVMFSLNE-------------LSSSKAVISPSR---------
Vps15_Ddis -----------TAGDDKRIKLWDWNN-------------LPQSYYVSIGKEPPPF-----
15015_Tthe ------------------------------------------------------------
VPS15_Spur -----------TAGSDQRIRYWNITN-------------PQQSSIIAGSVNDPVT-----
CC1G_08691_Ccin -----------TGSDDRRLRFWDLSR-------------AEKSVVFSGLEQDGER-----
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe -----------TGGTDCRIRLWDHLR-------------PETSYCICGPTVKNA------
VPS15-2_Smoe -----------TGGTDCRIRLWDHLR-------------PEASYCICGPTVKNA------
GK073_Glam DSKLENPVLQFVGGLDVRMSGHTKNRTKQQEKPAFSAITSHENSCILGLSNGAV------
PIK3R4_Hsap ----------------SVSYYRKIIEGTEVVQEIQNK-Q----------KVG--------
PIK3R4_Mmus ----------------SVSYYKKIIEGTEVVQEIQNK-Q----------KVG--------
CG9746_Dmel --------------DVAFNYGARLIDGSQVIEEQIISMA----------STGD-------
ZK930.1_Cele EENDTSTAPSGASTDPFVIYER-TVLD----TEAKEN-Q---------------------
VPS15_Scer -------------------FSDV-FIPTQVTANL--------------------------
Vps15_Ddis ---------------YTHKFSNDTSNAYEIHEEVWHDTSSSSFYSNSAMFGGGGGGQPMS
15015_Tthe -------------------------FDKRKTE--------------------K-------
VPS15_Spur --------------QLSVSYNHRVIDGTEVIVETYGK-Q----------RGGT-------
CC1G_08691_Ccin ---------------PTHSINSGGSRGGE---DEGNKGPVSYVETWPAVPTGG-------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ---------------PPFRYSSKTVCGLHITQESMHE-----------------------
VPS15-2_Smoe ---------------PPFRYSSKTVCGLHITQESMHE-----------------------
GK073_Glam ---------------LMVNECEKEIISCKMLSSPNKY-----------------------
PIK3R4_Hsap ----------------------------------PSDDTPRRGPESL-------------
PIK3R4_Mmus ----------------------------------PSDDTPRRGPESL-------------
CG9746_Dmel ----------------------------SQQLRSSTEENPRSGPDMP-------------
ZK930.1_Cele -------------------------------------KVV-P-LDSK-------------
VPS15_Scer -----------------------------TMLLRKMKRTS-THSVDD-------------
Vps15_Ddis TSLSSSSLSQQQHQAQLQLQYQLQQQQQQQQYINHLQQQKSKTSISM-------------
15015_Tthe ----------------------------NTKLISHLEKID-MIERDE-------------
VPS15_Spur ----------------------------GSAATSGSDESQRRSAEQV-------------
CC1G_08691_Ccin ---QSS---------------------RP----SQRISLITQHQQNL-------------
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ---------------------------------NVQSEVA-LAAVDM-------------
VPS15-2_Smoe ---------------------------------NVQSEVA-LAAVDM-------------
GK073_Glam ---------------------------------RITSNID-LASTDTVTNNHKKFGVFFS
PIK3R4_Hsap -----PVGHHDIITDVATFQTT-QGFIVTASRDGI-----VKVW-----K
PIK3R4_Mmus -----PVGHHDIITDIATFQTT-QGFIVTASRDGI-----VKVW-----K
CG9746_Dmel -----TASHHDAITDLLMCKDKGQIYIASASRNGV-----IKLW-----K
ZK930.1_Cele ----PSTYHRTPITDMMLLN---SELLVSSGYDGV-----IKIWK-----
VPS15_Scer -----SLYHHDIINSISTCEVDETPLLVACDNSGL-----IGIF-----Q
Vps15_Ddis ----PTVHHQEPILDIKMMEVP-NPMLISASTDGV-----VKVW-----K
15015_Tthe -----G-FFKDCLDKFLQNKSKPQSEIDQRILECMIGLDDPNCN-----Y
VPS15_Spur -----PVGHRDVITDMGVFQIS---------------------S-----S
CC1G_08691_Ccin -----LKSHQDVVTALACIDSPWRGGIVSGDRAGV-----VKVWRLDYVE
AqueK216_Aque ----------------------------SKKSKKS-----SKRI-----Q
VPS15-1_Smoe -----AGCHRDSITSLAA---A-SQLLISSSRDGT-----IKVW-----K
VPS15-2_Smoe -----AGCHRDSITSLAA---A-SQLLISSSRDGT-----IKVW-----K
GK073_Glam NQPSGLVAHQGPVVAIK---SS-GHSVFSADTSGL-----ILFYH-----