IRAKd_b-2_Smoe  MGAAMTPRSRSLDHRHRARRAPKMLVAAVIELLVLWAVLGRAALPGSQTQSLLRLQKLLG
IRAKd_b-1_Smoe  MGAAMTPRSRSLDRRHRARRAPTMLVAAVIELLVLWAVLGRAALPGSQTQSLLRLQKLLG
IRAKd_a_Smoe    MGPSIP-G----------------SIGAVVALLLVLAVEG-SSLPPSQIQSVLRLQRLLG
                **.::.                   :.**: **:: ** * ::** ** **:****:***

IRAKd_b-2_Smoe  DPSALGGWSVNTS----FCSLPSSPMLNVSCAYADQS---GTQTVILLQIVGDKLPITVR
IRAKd_b-1_Smoe  DPSALGGWSANTS----FYSLV--------CHKTLSFFSIKNETLVTTKQVSHAFP-QVR
IRAKd_a_Smoe    YPSALAHIDSNATQGLDLCGIPPSLVFNLSCNSSAGS---FSSTIVSIQILGNA----TS
                 ****.  . *::    : .:         *  :       ..*::  : :..     .

IRAKd_b-2_Smoe  LPDDFSIITLANTLVKFPDLRTLTLVSLGIWGLVPASLDHLRSLELLNLSSNFLSGSIPD
IRAKd_b-1_Smoe  LPDDFSIITLANTLVKFPDLRTLTLVSLGIWGLVPASLDHLRSLELLNLSSNFLSGSIPD
IRAKd_a_Smoe    LSRDFSMETLGNLLSALPELEILGLVHLGLWGSIPPKLDHLQSLRVLDLSENSISGALPD
                *. ***: **.* *  :*:*. * ** **:** :*..****:**.:*:**.* :**::**

IRAKd_b-2_Smoe  RFSSLGSLQSLALDNNILRGTFPTALNVLPNLDTLQLSHNQIAGTIPSQISLFASLKTLD
IRAKd_b-1_Smoe  RFASLGSLQSLALDNNILRGTFPTALNVLPNLDTLQLSHNQIAGTIPSQISLFASLKTLD
IRAKd_a_Smoe    RLRALSRL------------------------EILQLKDNRLNGTLPGWIGELRSLRELD
                *: :*. *                        : ***..*:: **:*. *. : **: **

IRAKd_b-2_Smoe  MDHNLLFGALPDSISNMR--VAETISISDNFLAGVVPNLSRVASLRTLNLAGNQLGPSFP
IRAKd_b-1_Smoe  MDHNLLFGALPDSISNMR--VAETISISDNFLAGVVPNLSRVASLRTLNLAGNQLGPSFP
IRAKd_a_Smoe    LSNNAITGKLPKSLFSSRRNRLERLVVSHNDFSGNLPDWSSDSLLVYFNAGANHIGPSFP
                :.:* : * **.*: . *    * : :*.* ::* :*: *  : *  :* ..*::*****

IRAKd_b-2_Smoe  GLGQG--LVSANLERNRFSDSIP-DSLRGLSQLKLLNLSLNSIPGALPGWIFSLQSLETL
IRAKd_b-1_Smoe  GLGQG--LVSANLERNRFSDSIP-DSLRGLSQLKLLNLSLNSIPGALPGWIFSLQSLETL
IRAKd_a_Smoe    KLGYGGLLQSLLLGQNDITGGIPHDAAARLGGVRTMDLSYNELHGMPPAALFRLGHIETL
                 ** *  * *  * :* ::..** *:   *. :: ::** *.: *  *. :* *  :***

IRAKd_b-2_Smoe  VLDHNRLSGTLPSAVTLASGLRYVDISTNLLMGEVPAELR--SGRITLHVEENCFSGQEI
IRAKd_b-1_Smoe  VLDHNRLSGTLPSAVTLASGLRYVDISTNLLMGEVPAELR--SGRITLHVEENCFSGQEI
IRAKd_a_Smoe    ALNGNQFLGVLPYNLSLSPSLALLDLSSNFFTGRVPASFLGSGGSVVVRFGKNCFAT---
                .*: *:: *.**  ::*:..*  :*:*:*:: *.***.:   .* :.::. :***:

IRAKd_b-2_Smoe  QLQQQQPQEYCLKAQRM----------IPRRWKGGVVAGIAGGVMAVGAAMALLLVILLR
IRAKd_b-1_Smoe  QLQQQQPQEYCLKAQRM----------IPRRWKGGVVAGIAGGVMAVGAAMALLLVILLR
IRAKd_a_Smoe    RVQQQYTRSHCDAAARKRAAASAAAASTPDSHDLAIIAGIVGGGIALVGAVAVFLCVLLR
                ::*** .:.:*  * *            *   . .::***.** :*: .*:*::* :***

IRAKd_b-2_Smoe  FSKRGKLKLKHAAATCANNSCADTASVGVPLELLHSTRYLAQSGTVGATGPNQCRVFSLL
IRAKd_b-1_Smoe  FSKRGKLKLKHAAATCANNSCADTASVGVPVELLHSTRYLAQSGTVGATGPNQCRVFSLL
IRAKd_a_Smoe    CLRQQKDD---KPVQYAASSCADTASIGVPSDLLSNARYLSQSIRLGVHSTSHNRVFSVP
                  :: * .    ..  * .*******:*** :** .:***:**  :*. ...: ****:

IRAKd_b-2_Smoe  ELEEATSRFSQGLLIGEGEYGKVFRGKLDDGTLVAIKCLVIDSRQEMKQLKAHLEFLSRI
IRAKd_b-1_Smoe  ELEEATSRFSQGLLIGEGEYGKVFRGKLDDGTLVAIKCLVIDSRQEMKQLKAHLEFLSRI
IRAKd_a_Smoe    ELEEATANFSLENLIGEGQHGKVFKGKLHDGTVAAVKCLTLDSRQDMRQLKIHVELLVKI
                ******:.**   *****::****:***.***:.*:***.:****:*:*** *:*:* :*

IRAKd_b-2_Smoe  RHRHLVSLFGYCLEREKDGP-QHRRLYLVSEFIDNGTLRSHLFKR---------------
IRAKd_b-1_Smoe  RHRHLVSLFGYCLEREKDGP-QHRRLYLVSEFIDNGTLRSHLFKR---------------
IRAKd_a_Smoe    RHRHLVGYIGYSLDNVIDGARQCRKLYLVSEYIDNGTLRNHLSSKFVTGLLGLMFCFSDL
                ******. :**.*:.  **. * *:******:*******.** .:

IRAKd_b-2_Smoe  ----KLKESLTWQNRLVAALGAGRGIHYLHTGVVPGIFNNDVRVTNVLLDHNFVGKVSDF
IRAKd_b-1_Smoe  ----KLKESLTWQNRLVAALGAGRGIHYLHTGVVPGIFNNDVRITNILLDHNFVGKVSDF
IRAKd_a_Smoe    PVEAEGREVLSWSQRLAAAIGAGRGIQYLHTGVVPGIFNNDVNITNVLMDQNCVAKFTDF
                    : :* *:*.:**.**:******:***************.:**:*:*:* *.*.:**

IRAKd_b-2_Smoe  GLARHPESESYQSYGS----------------DLATDKRDVYNFGLILLEIVLGRPPTVD
IRAKd_b-1_Smoe  GLARHPESESYQSYGSDVSN-SSKVLVIIPTLKLATDKRDVYNFGLTLLEIVLGRPPTVD
IRAKd_a_Smoe    GIGKHARTSCDFDAKVYVQKTPAHIDLDHHRRKLASDKTDVYNFGFILLEILLGKPPTIE
                *:.:*..:..  .                   .**:** ******: ****:**:***::

IRAKd_b-2_Smoe  NPM-AMKPKVQELVSSSSSVFRTEMVDSAISGTCSEDSLSTVLEIAAKCLSSDLTARPSM
IRAKd_b-1_Smoe  NPM-AMKPKVQELVSSSSSVFRTEMVDSAISGTCSEDSLSTVLEIAAKCLSSDLTARPSM
IRAKd_a_Smoe    DSKSSVHPK--EMLQ-TEHVPRYEVVDPAIIGNCVAESLTTVLEIAAKCLSEEPSSRPSM
                :.  :::**  *::. :. * * *:**.** *.*  :**:***********.: ::****

IRAKd_b-2_Smoe  EDVLWNLQYAVQVQDQRF------------------------------------------
IRAKd_b-1_Smoe  EDVLWNLQYAVQVQDQRF------------------------------------------
IRAKd_a_Smoe    EDVLWNLQYAAQVQDRRAMALGPDIRVSTLHSPPILRRAVAPCTLRRGYAGNLLRRGGFV
                **********.****:*

IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    GLTRHWRGNAVRDENAIAGKGEKSMLGAFSEEDEDCSDGSEEESSGEEEDFGFGEFRFAS


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    DDGAEEGADDASEELDSFAERARRIDDLCAKVAQGKQISSADLIGLYSFRLDKFQRLAIE


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    GFLKGSSVVVSAPTSSGKTLIAEAAAAATLAKCKRLFYTTPLKALSNQKFRDFRKIFGDS


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    SVGLLTGDVSINRDAPIVIMTTEIMRNKFYLSAGNEDVLQDLDVVVLDEIHYISDLTRGT


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    VWEETARVIYCPKRIKLVCLSATIANPDELAGWIAKVHGPTELITSYRRPVPLTWHISRR


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    SQMLPLLNEKGTAINRKLLIDKKQLEEVNSRKIRGRISTLEKMTEEQLQVLLRVQVFLTI


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    LFGQLSNSCISCQVPRISDTLKQMVERTMLPAIWFILSRRRCDEAVQYLQHANLLAEDEF


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    QQIDLALKSFREQYPDAIREAAVRPLYQGVAAHHAGCLPLWKSFIEELFQKGLVKVVFAT


IRAKd_b-2_Smoe  -------------------SGEY-------------------------------------
IRAKd_b-1_Smoe  -------------------SGEY-------------------------------------
IRAKd_a_Smoe    ETLAAGINMPARTTVLSSFSGKYQRRISANVVLQMAGRAGRRGIDKEGHVVVVQTPFRGP
                                   **:*

IRAKd_b-2_Smoe  ----------------------------LEDSS---------------------------
IRAKd_b-1_Smoe  ----------------------------LEDSS---------------------------
IRAKd_a_Smoe    EECYKMLRTGLEPLVSQFTATYGMALNLLEDSAVESETLSSEQRQSFGEARSLIEQSFGN
                                            ****:

IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    YIGSEILTGARAKMVQISSEIETLESGQSTDSLSKLYEEKINEFNKMREKVETQERKERS


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    LRFKFERHRLSFLQSQLKQLSLEQVPYVLLTYEDINTGEGHTLSVAVFHMTENNPFILGV


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    NENHEPKVEDMDASFIGVGCDSFLYRFPLKVVRKVYRSTIGAEERTALKSNLADVQWEIV


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    GNDNVSRCQSSFPPHGYEVPVPNTLTSECAMPEELVTAEKLLLMQQRSLGKWSRRLAEID


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    EVEIDNLVAKVKQMREEKVARLKAKLERIGKRIKGMQPSGWKEFLQVVKILKDAGAMDRN


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    THKLLPLGEIARAIRGSNELWLAIALRDEALLSLKPSELAAVAAALVTESPKSIPDNEYR


IRAKd_b-2_Smoe  ------------------------------------------------------------
IRAKd_b-1_Smoe  ------------------------------------------------------------
IRAKd_a_Smoe    TIYEPSAVVKEWVEKMQSERLWLYGLQENHNVEFACDLDPQLAGFVEAWAAGVNWKELEI


IRAKd_b-2_Smoe  ----------------------------------------------------GRE
IRAKd_b-1_Smoe  ----------------------------------------------------GRE
IRAKd_a_Smoe    EDIMDEGDFARLLRRTIDLLSQIPHLPHIDSELSKIAKEAARNMDRPPISEPVGE
                                                                      *