Alignment of Subfamily IRAKf

Protein (view, download) , Domain (view, download) 
IRAKf_k-2_Smoe  MGFLRHGS-------IL-----------------------------SLTGVVLLEIKKSL
IRAKf_c-1_Smoe  MSARIHGRRAGAPGKIDSVLFLAILALILASLPRHSAGEEDETVSWNDDVLGLLVFKAGL
IRAKf_c-2_Smoe  MSARIHGRRAGAPGKIDSVLFLAILALILASLPRHSTGEGDETVSWNDDVLGLLVFKAGL
IRAKf_d-1_Smoe  MSIGQQCR-------ILAIEFLVVLVAAFQA------------RALNEEGIALMAFRMQI
IRAKf_d-2_Smoe  MSIGQQCR-------ILAIEFLVVLVAAFQA------------RALNEEGIALMAFRMQI
IRAKf_g_Smoe    -------------------------------------------------GQALLAFKASL
IRAKf_m-2_Smoe  -------------------------------------------------GAVLLEIKKSF
IRAKf_g-1_Smoe  -------------------------------------------------GIALLAFKEGI
IRAKf_m-1_Smoe  -------------------------------------------------GAVLLEIKKSF
IRAKf_g-2_Smoe  -------------------------------------------------GIALLAFKEGI
IRAKf_n-2_Smoe  MSWFL---------------WLLLLAASLTPS----------LAQLSGDGIALLAVKKAL
IRAKf_n-1_Smoe  MSWFL---------------WLLLLAASLSAS----------LAQLSGDGIALLAVKKAL
IRAKf_a_Smoe    --------------------------------------------------------RADL
IRAKf_k-1_Smoe  MGFLRHGS-------IF-----------------------------SLTGVVLLEIKKSL
IRAKf_b_Smoe    MEARLD-----------MVVVVVVVFFLSLALPVES---SDIVLPWNDDVLGLIVFKADL
                                                                        :  :

IRAKf_k-2_Smoe  -NNADN-VLYDWEGAIDRDPCFWRGVSCDNVTLAVIGLNLTQLGL---SGEISPAFGRLK
IRAKf_c-1_Smoe  -QDPRG-SLASWSE-ADSSPCNWTGIRCGSASGRVESVSLDGLAL---SGTIGRGLLKLE
IRAKf_c-2_Smoe  -QDPRG-SLASWSE-ADSSPCNWTGIRCGSASGRVESVSLDGLAL---SGTIGRGLLKLE
IRAKf_d-1_Smoe  TQDPTG-IFTSWNA-ADEDPCGWTGVFCDDD-NRVKKLLIHGAGL---AGTISPALSGLP
IRAKf_d-2_Smoe  TQDPTG-IFTSWNA-ADEDPCGWTGVFCDDD-NRVKKLLIHGAGL---AGTISPALSGLP
IRAKf_g_Smoe    -NDSAGALLLDWIE-SDSHPCRWTGVSCHPQTTKVKSLNLPYRRL---VGTISPELGKLD
IRAKf_m-2_Smoe  -SNAGN-ALYDWDGSADHDPCFWRGVTCDNVTLSVTGLNLTQLSL---SGVISPSVGKLK
IRAKf_g-1_Smoe  -QEAQF-LLGDWRR-SDATPCNWTGVECNGETGRVETLNLPRFHL---VGVISPEIGKLS
IRAKf_m-1_Smoe  -SNAGN-ALYDWDGSADHDPCFWRGVTCDNVTLSVTGLNLTQLSL---SGVISPSVGKLK
IRAKf_g-2_Smoe  -QEAQF-LLGDWRR-SDATPCNWTGVECNGETGRVETLNLPRFHL---VGVISPEIGKLS
IRAKf_n-2_Smoe  --DPSD-ALSGWNA-GSVDPCLWAGVSCAQ-DRRVTSLNLTGAFLGTCSSSHSDSWENLR
IRAKf_n-1_Smoe  --DPSD-ALSGWNA-GSVDPCLWAGVSCAQ-DRRVTSLNLTGAFLGTCSSSHSDSWENLR
IRAKf_a_Smoe    -HDPRR-ALASWSE-DSASPCNWTGIQCSPQSGRVTQL----------------------
IRAKf_k-1_Smoe  -NNADN-VLYDWEGAIDRDPCFWRGVSCDNVTLAVIGLNLTQLGL---SGEISPAFGRLK
IRAKf_b_Smoe    -HDPRR-ALASWSE-DSASPCNWTGIQCSPQSGRVTQVTLDGLEL---SGPLGRGLLKLD
                  :.    : .*    .  ** * *: *      *  :

IRAKf_k-2_Smoe  SLQYLDLRENSLSGQIPDEIGQ-C-VNLKTIDLSFNAFHGDIPF-SISQLKQLENLILKN
IRAKf_c-1_Smoe  RLKTLSLSANNLSGNVVPELFR----MLDFVDLK-------------------------K
IRAKf_c-2_Smoe  RLKTLSLSANNLSGNVVPELFR----MLDFVDLK-------------------------K
IRAKf_d-1_Smoe  FLRTLSLSNNLLKGSIPSQL---------------------------SHISSLWKLNLSS
IRAKf_d-2_Smoe  FLRTLSLSNNLLKGSIPSQL---------------------------SHISSLWKLNLSS
IRAKf_g_Smoe    RLARLALHHNSFYGTIPSEL----------------------------------------
IRAKf_m-2_Smoe  SLQYLDLRENSIGGQIPDEIGD-C-AVLKYIDLSFNALVGDIPF-SVSQLKQLETLILKS
IRAKf_g-1_Smoe  KLRRLGLHNNMISGKIPPSL----------------------------------------
IRAKf_m-1_Smoe  SLQYLDLRENSIGGQVPDEIGD-C-AVLKYIDLSFNALVGDIPF-SVSQLKQLETLILKS
IRAKf_g-2_Smoe  KLRRLGLHNNMISGKIPPSL----------------------------------------
IRAKf_n-2_Smoe  KLQVLSLQENSFSGGIPAELGA-L-SSLEVLDLEGNLLDGPIPP-AIASCRSLVHISLGR
IRAKf_n-1_Smoe  KLQVLSLQENSFSGGIPAELGA-L-SSLEVLDLEGNSLDGPIPP-AIASCRSLVHISLGR
IRAKf_a_Smoe    -LSLLDVSHNSFSGSVPPELFANCSKSLRYVFLSGNQLEGDLPD-SIASCESLEALGASE
IRAKf_k-1_Smoe  SLQYLDLRENSLSGQIPDEIGQ-C-VNLKTIDLSFNAFHGDIPF-SISQLKQLENLILKN
IRAKf_b_Smoe    HLQVLSLARNNLSGSISPQIRV-L-KSLRNLSLSHNALSGPLPGASLASLELLSLLDVSQ
                 *  * :  * : * :  .:

IRAKf_k-2_Smoe  NQLTGPIPSTLSQ--LPNLKTLDLAQNKLTGEIPTLLYW-SEVLQYLGLRDNLLTGNLSP
IRAKf_c-1_Smoe  NRLSGELPSPMGA----SIRYVDLSDNAFTGALARDFFGGGHLLRYLSLSKNRLTGQLSP
IRAKf_c-2_Smoe  NRLSGELPSPMGA----SIRYVDLSDNAFTGALARDFFGGGHLLRYLSLSKNRLTGQLSP
IRAKf_d-1_Smoe  NELAGTIPASIGK--IPGLRMLDLSSNLLTGAIPPQLFGNCSKLRFVSLSGNAL------
IRAKf_d-2_Smoe  NELAGTIPASIGK--IPGLRMLDLSSNLLTGAIPPQLFGNCSKLRFVSLSGNAL------
IRAKf_g_Smoe    ------------------------------------------------------------
IRAKf_m-2_Smoe  NQLTGPIPSTLSQ--LPNLKTLDLAQNQLTGEIPTLLYW-SEVLQYLGLRDNSLSGTLSS
IRAKf_g-1_Smoe  ------------------------------------------------------------
IRAKf_m-1_Smoe  NQLTGPIPSTLSQ--LPNLKTLDLAQNQLTGEIPTLLYW-SEVLQYLGLRDNSLSGTLSS
IRAKf_g-2_Smoe  ------------------------------------------------------------
IRAKf_n-2_Smoe  NKLSGGIPASLGG--LSRLRHLSLTSNQLSSVIPPGLQGLCGTLEYLDLGSNFFIRGIPP
IRAKf_n-1_Smoe  NKLSGGIPASLGG--LSRLRHLSLTSNQLSSVIPPGLQGLCGTLEYLDLGSNFFIRGIPP
IRAKf_a_Smoe    NRLSGSIPAGVGS--LSRLGSLDLSHNSLSGEIPP-------------------------
IRAKf_k-1_Smoe  NQLTGPIPSTLSQ--LPNLKTLDLAQNKLTGEIPTLLYW-SEVLQYLGLRDNLLTGNLSP
IRAKf_b_Smoe    NSFSGSVPPELFANCSKSLRYVFLSGNQLEGDLPDSIAS-CESLEALGASENRLSGSIPA


IRAKf_k-2_Smoe  DMC-RLTGLWYFDIRSNNITGPIPENIGNCTSYEILDLSYNQLTGEIPFNIGF-LQVATL
IRAKf_c-1_Smoe  SLAANQTG------------------------------------------------LVTL
IRAKf_c-2_Smoe  SLAANQTG------------------------------------------------LVTL
IRAKf_d-1_Smoe  ------------------------------------------------------------
IRAKf_d-2_Smoe  ------------------------------------------------------------
IRAKf_g_Smoe    ------------------------------------------------------------
IRAKf_m-2_Smoe  DMC-RLTGLWYFDVRSNNISGIIPDNIGNCTSFEILDLAYNRLNGEIPYNIGF-LQVATL
IRAKf_g-1_Smoe  ------------------------------------------------------------
IRAKf_m-1_Smoe  DMC-RLTGLWYFDVRSNNISGIIPDNIGNCTSFEILDLAYNRLNGEIPYNIGF-LQVATL
IRAKf_g-2_Smoe  ------------------------------------------------------------
IRAKf_n-2_Smoe  WLG-NCSKLQVLVLESNYLQGFIPSELGRLGMLQVLDVSMNRLTGQVPAALGDCLELSFL
IRAKf_n-1_Smoe  WLG-NCSKLQVLVLESNYLQGFIPSELGRLGMLQVLDVSMNRLTGQVPAALGDCLELSFL
IRAKf_a_Smoe    -------------------------ELGQCQMLVSLDLSYNLLSGEIPSFLESLSRLEVL
IRAKf_k-1_Smoe  DMC-RLTGLWYFDIRSNNITGPIPENIGNCTSYEILDLSYNQLTGEIPFNIGF-LQVATL
IRAKf_b_Smoe    GVG-SLSRLSSLDLSHNSLSGEIPPELGQCQMLVSLDLSYNLLSGEIPSFLESLSRLEVL


IRAKf_k-2_Smoe  SL------------------------QGNKLVGKIPDVIG-LMQALAVLDLSNNFLEGSI
IRAKf_c-1_Smoe  RI------------------------AENGFSGDLPDWIGKSLRALQELDLSWNGFQGSI
IRAKf_c-2_Smoe  RI------------------------AENGFSGDLPDWIGKSLRALQELDFSWNGFQGSI
IRAKf_d-1_Smoe  -------------------------------AGSLPVALGS-CGSLKFVDFSSNRLT---
IRAKf_d-2_Smoe  -------------------------------AGSLPVALGS-CGSLKFVDFSSNRLT---
IRAKf_g_Smoe    ------------------------------------------------------------
IRAKf_m-2_Smoe  SL------------------------QGNQFSGKIPEVIG-LMQALAVLDLSDNRLVGDI
IRAKf_g-1_Smoe  ------------------------------------------------------------
IRAKf_m-1_Smoe  SL------------------------QGNQFSGKIPEVIG-LMQALAVLDLSDNRLVGDI
IRAKf_g-2_Smoe  ------------------------------------------------------------
IRAKf_n-2_Smoe  VLTHPSSCVSPFNCTTGDGVRGVDKAEFNQFDGPLPSSIS-KLPKLQVLWAPHAALTGGI
IRAKf_n-1_Smoe  VLTHPSSCVSPFNCTTGDGVRGVDKAEFNQFDGPLPSSIS-KLPKLQVLWAPHAALTGGI
IRAKf_a_Smoe    RL------------------------PGNSFSGGVPEWIVTGFPELQELNLAENDLGGTL
IRAKf_k-1_Smoe  SL------------------------QGNKLVGKIPDVIG-LMQALAVLDLSNNFLEGSI
IRAKf_b_Smoe    RL------------------------PGNSFSGGVPEWIVTGFPELQELNLAENDLGGTL


IRAKf_k-2_Smoe  PSILGNLTFTGKLYLHGNMLTGVIPPELGNMTKLSYLQLNDNNLTGQIPPELGSLSELFE
IRAKf_c-1_Smoe  PPSLATLSSLRSLNLAGNNLTGVVPQSLLQLLRLSSLDLSSNHLGGKIPFGLFS-SSLQF
IRAKf_c-2_Smoe  PPSLATLSSLRSLNLAGNNLTGVVPQSLLQLLRLSSLDLSSNHLGGKIPFGLFS-SSLQF
IRAKf_d-1_Smoe  ---------------------GSVPAEIAFLDELLLLLIQENSLSGDFPSEVLYLPSLDI
IRAKf_d-2_Smoe  ---------------------GSVPAEIAFLDELLLLLIQENSLSGDFPSEVLYLPSLDI
IRAKf_g_Smoe    ------------------------------------------------------------
IRAKf_m-2_Smoe  PALLGNLTYTGKLYLHGNLLTGTIPPELGNMTKLSYLQLNDNQLTGEIPSELGSLSELFE
IRAKf_g-1_Smoe  ------------------------------------------------------------
IRAKf_m-1_Smoe  PPLLGNLTYTGKLYLHGNLLTGTIPPELGNMTKLSYLQLNDNQLTGEIPSELGSLSELFE
IRAKf_g-2_Smoe  ------------------------------------------------------------
IRAKf_n-2_Smoe  PDGWGACERLRSLNLAGNSFTGDFPQGLGKCSSLTYLDLSLNRLEAQLPPQLPT-SCMIV
IRAKf_n-1_Smoe  PDGWGACERLRSLNLAGNSFTGDFPQGLGKCSSLTYLDLSLNRLEAQLPPQLPT-SCMIV
IRAKf_a_Smoe    PSSIGSMKALRRLYLHNNNLQGALPPALAGCFNLSTIDLSSNNFSGAIPDEIFE-LELER
IRAKf_k-1_Smoe  PSILGNLTFTGKLYLHGNMLTGVIPPELGNMTKLSYLQLNDNNLTGQIPPELGSLSELFE
IRAKf_b_Smoe    PSSIGSMKALRRLYLHNNNLQGALPPTLGGCFNLSTIDLSSNNFSGAIPDEIFE-LELES


IRAKf_k-2_Smoe  LDLSNNKFSGPFPKNV--------------------------------------------
IRAKf_c-1_Smoe  LNLSRNEFLGDFPIW---------------------------------------------
IRAKf_c-2_Smoe  LNLSRNEFLGDFPIW---------------------------------------------
IRAKf_d-1_Smoe  LNGSKNAFSGGLPDRQ--------------------------------------------
IRAKf_d-2_Smoe  LNGSKNAFSGGLPDRQ--------------------------------------------
IRAKf_g_Smoe    ------------------------------------------------------------
IRAKf_m-2_Smoe  LNLANNQLYGRIPENI--------------------------------------------
IRAKf_g-1_Smoe  ------------------------------------------------------------
IRAKf_m-1_Smoe  LNLANNQLYGRIPENI--------------------------------------------
IRAKf_g-2_Smoe  ------------------------------------------------------------
IRAKf_n-2_Smoe  FNVSRNSLSGDVLPRRSIECNDTQEPVVYPSFCSGRPFCGKRRSETCLSSGLIVVHDISG
IRAKf_n-1_Smoe  FNVSRNSLSGGVPPRRSIECNDTQEPVVYPSFCSGRPFCGKRRSETCLSSGLIVVHDLSG
IRAKf_a_Smoe    LALAMNSFSGGLPVALS-SS----------------------------------------
IRAKf_k-1_Smoe  LDLSNNKFSGPFPKNV--------------------------------------------
IRAKf_b_Smoe    LALAMNSFSGGLPAALS-SS----------------------------------------


IRAKf_k-2_Smoe  -----------------------------------------SYCSSLNY--INVHGNMLN
IRAKf_c-1_Smoe  -----------------------------------------PPCHALQV--VDISGNRIF
IRAKf_c-2_Smoe  -----------------------------------------PPCHALQV--VDISGNRIF
IRAKf_d-1_Smoe  ---------------------------------------GDDGCRSLEV--LDLSYNSFE
IRAKf_d-2_Smoe  ---------------------------------------GDDGCRSLEV--LDLSYNSFE
IRAKf_g_Smoe    ------------------------------------------------------------
IRAKf_m-2_Smoe  -----------------------------------------SSCNALNY--LNVHGNRLN
IRAKf_g-1_Smoe  ------------------------------------------------------------
IRAKf_m-1_Smoe  -----------------------------------------SSCNALNY--LNVHGNRLN
IRAKf_g-2_Smoe  ------------------------------------------------------------
IRAKf_n-2_Smoe  NNFSGPVPAPLIGDELLEQEPVYELLMSENRLAGNIPSSFFAFCGRFKAFMANLSDNQIS
IRAKf_n-1_Smoe  NNFSGPVPAPLIGDELLEQEPVYELLMSENRLAGNISSSFFAFCGRFKAFMANLSDNQIS
IRAKf_a_Smoe    --------------------------------------NSSSACKVIQS--LDLSRNSLE
IRAKf_k-1_Smoe  -----------------------------------------SYCSSLNY--INVHGNMLN
IRAKf_b_Smoe    --------------------------------------NSSSACKVIQS--LDLSRNSLE


IRAKf_k-2_Smoe  GTVPP-ELQDLGSLTYLNLSSNSFSGRIPEEL-GHIVNLDTMDLSENILTGHIPRSIGNL
IRAKf_c-1_Smoe  GEVPS-RIAQCSSLQHLNVGWNVLSGGIPGQI-SQLQRLMFLDLSHNQLQGGIPSTFTNM
IRAKf_c-2_Smoe  GEVPS-RIAQCSSLQHLNVGWNVLSGGIPGQI-SQLQRLMFLDLSHNQLQGGIPSTFTNM
IRAKf_d-1_Smoe  GPIPS-NFGECQELSLINLSHNRFSSPIPDAI-GKLAFLVSLDLSSNAMHGSIPQALTQA
IRAKf_d-2_Smoe  GPIPS-NFGECQELSLINLSHNRFSSPIPDAI-GKLAFLVSLDLSSNAMHGSIPQALTQA
IRAKf_g_Smoe    ------------------------------------------------------------
IRAKf_m-2_Smoe  GSIPP-QLKKLDSLTYLNLSSNLFSGSIPDDF-GHIVNLDTLDVSDNYISGSIPSSVGDL
IRAKf_g-1_Smoe  ------------------------------------------------------------
IRAKf_m-1_Smoe  GSIPP-QLKKLDSLTYLNLSSNLFSGSIPDDF-GHIVNLDTLDVSDNYISGSIPSSVGDL
IRAKf_g-2_Smoe  ------------------------------------------------------------
IRAKf_n-2_Smoe  GELSGQDIGGCKSLVQFSASNNLIEEALPKEL-GTLGNLSLLDLSRNRLSGSIPGELGEL
IRAKf_n-1_Smoe  GELSGQDIGGCKSLVQFSASNNLIEEALPKEL-GTLGNLSLLDLSRNRLSGSIPGELGEL
IRAKf_a_Smoe    GEIPP-QVSGCQHLRSLNLGQNGLSGSIPEELVAGLSELSSLDLSSNFLTGYIPRSFGGS
IRAKf_k-1_Smoe  GTVPP-ELQDLGSLTYLNLSSNSFSGRIPEEL-GHIVNLDTMDLSENILTGHIPRSIGNL
IRAKf_b_Smoe    GEIPP-QVSGCQHLRSLNLGQNGLSGNIPEELVAGLSELSSLDLGSNFLTGYIPRSFGGS


IRAKf_k-2_Smoe  EHLLTLVLKHNKLTGGIPSEFGSLKSIYAMDLSENNLSGSIPPELGQLQTLNALLLEKNS
IRAKf_c-1_Smoe  SSLTVLKLAKNLLVGNIPKAISKCERLVELDLSSNRLSGSIPGALSRLNFLQSLDLAWNN
IRAKf_c-2_Smoe  SSLTVLKLAKNLLVGNIPKAISKCERLVELDLSSNRLSGSIPGALSRLNFLQSLDLAWNN
IRAKf_d-1_Smoe  RFLIELKLSSNDLSGTIPRSLNNLTFLKTLLLGHNMLQGSIPAEVGRLTHLERLDLSFNN
IRAKf_d-2_Smoe  RFLIELKLSSNDFSGTIPRSLNNLTYLKTLLLGHNMLQGSIPAEVGRLTHLERLDLSFNN
IRAKf_g_Smoe    ---------------------GNCTRLRALYLKNNYLGGTIPKEFGRLASLRILDVSSNS
IRAKf_m-2_Smoe  EHLLTLILRNNDISGKIPSEFGNLRSIDLLDLSQNKLSGNIPPELGQLQTLNTLFLQHNK
IRAKf_g-1_Smoe  ---------------------GNCSDLRAVYLRDNLLSGSLPAELGRLKNLKVFDVSENS
IRAKf_m-1_Smoe  EHLLTLILRNNDISGKIPSEFGNLRSIDLLDLSQNKLLGNIPPELGQLQTLNTLFLQHNK
IRAKf_g-2_Smoe  ---------------------GNCSDLRAVYLRDNLLSGSLPAELGRLKNLKVFDVSENS
IRAKf_n-2_Smoe  QMLTSLFLANNSLVGDIPEKLGQASSLSLLDLSGNTLNGTIPSSLANLSHLEYLLLNNND
IRAKf_n-1_Smoe  QMLTSLFLANNSLVGDIPENLGQASSLSLLDLSGNTLHGTIPSSLANLSHLEYLLLNNND
IRAKf_a_Smoe    PSLETLKLDDNALVGIIPEGLGNCSSLRYLDLSQNNLTGGIPVELADLSSLQSLDLSSNH
IRAKf_k-1_Smoe  EHLLTLVLKHNKLTGGIPSEFGSLKSIYAMDLSENNLSGSIPPELGQLQTLNALLLEKNS
IRAKf_b_Smoe    PSLETLKLDDNALVGIIPEELGNCSSLRYLDLSQNNLTGGIPVELADLSSLQSLDLSSNH
                                     ..   :  : *  * * * :*  .. *  *. : :  *

IRAKf_k-2_Smoe  LSGSIPPQLGNCFSLSTLKSTALWWIH-----------ETNVQRLQEEVIWYIKSLFF--
IRAKf_c-1_Smoe  LTGPIPKELVKLESLSSLDVSHNHLDGPIPKGGVF-NLVNR---T-----AFQGNSGL--
IRAKf_c-2_Smoe  LTGPIPKELVKLESLSSLDVSHNHLDGPIPKGGVF-NLVNR---T-----AFQGNSGL--
IRAKf_d-1_Smoe  ITGSIPIQLGDLSHLVLFNVSYNNLTGFIPRRGVL-QRFDR---S-----SYIGNTFL--
IRAKf_d-2_Smoe  ITGSIPIQLGDLSHLVLFNVSYNNLTGFIPRRGVL-QRFDR---S-----SYIGNTFL--
IRAKf_g_Smoe    LTGSVPDVLGDLKQLVFLNVSTNALIGEIPSNGVL-SNFSQ---H-----SFLDNLGL--
IRAKf_m-2_Smoe  LSGAIPVQLTNCFSLNILNVSYNNLSGEVPSGTIF-SKFTP---D-----SYIGNSQL--
IRAKf_g-1_Smoe  LTGPIPASMERLNDLVFLNVSNNFLTGSVTG---L-AKFSN---R-----SFFGNPGL--
IRAKf_m-1_Smoe  LSGAIPVQLTNCFSLNILNVSYNNLSGEVPSGTIF-SKFTP---D-----SYIGNSQL--
IRAKf_g-2_Smoe  LTGPIPASMERLNDLVFLNVSNNFLTGSVTG---L-AKFSN---R-----SFFGNPGL--
IRAKf_n-2_Smoe  FSGTIPPVLSDITSLVAVNLAFNNFSGSVPSSGSWVGMCDK---E-----HFQGNPYLKP
IRAKf_n-1_Smoe  FSGTIPPVLSDITSLVAVNLAFNNFSGSVPSSGSWVGMCDK---E-----HFQGNPYLKP
IRAKf_a_Smoe    LTGQIPTSFAQLQNLSLFNVSHNSLAGPIPSDGAF-PLLDP---S-----SFAGNAHL--
IRAKf_k-1_Smoe  LSGSIPPQLGNCFSLSTLNLSYNNLSGEIPASSIF-NRFSFDRHV-----VYVGNLQL--
IRAKf_b_Smoe    LTGQIPTSFAQLQNLSLFNVSHNSLAGPIPSDGAF-PLLDP---S-----SFAGNAHL--
                ::* :*  :     *  .. :                              :  .  :

IRAKf_k-2_Smoe  FHLAFYSS-IF------------------------FFH--LRVETMGASAILGISIGSMC
IRAKf_c-1_Smoe  CGAALDVACSTVPKPI-VLNPNASSDTAGILQSGGHRG--KNKIVLSVSAIIAISAAAVI
IRAKf_c-2_Smoe  CGAALDVACSTVPKPI-VLNPNASSDTAGILQSGGHRG--KNKIVLSVSAIIAISAAAVI
IRAKf_d-1_Smoe  CGPPLSLRCTPMVWPGPALSPTL------------E--GGGKTHVLTPYTIAAIVAAILV
IRAKf_d-2_Smoe  CGPPLSLRCTPMVWPGPALSPTL------------E--GGGKTHVLTPYTIAAIVAAILV
IRAKf_g_Smoe    CGAQVNTSCRMAT-P-R-----------------RKTA--NYSNGLWISALGTVAISLFL
IRAKf_m-2_Smoe  CGTSTKTVCG-------------------------YRS--KQSNTIGATAIMGIAIAAIC
IRAKf_g-1_Smoe  CGQQLNKSCEVGK-S-V---------------NGSKMS--KLSRNLLISALGTVTASLLF
IRAKf_m-1_Smoe  CGTSTKTVCG-------------------------YRS--KQSNTIGATAIMGIAIAAIC
IRAKf_g-2_Smoe  CGQQLNKSCEVGK-S-V---------------NGSKMS--KLSRNLLISALGTVTASLLF
IRAKf_n-2_Smoe  CPTSLAAFGPGYME--ENLDPVAA--------PQ----DPPAGGGLSVVVIVAITSGCAV
IRAKf_n-1_Smoe  CPTSLAAFGPGYME--ENLDPVAA--------PQ----DPPAGGGLSVVVIVAITSGCAV
IRAKf_a_Smoe    CGASLSIDCPAIPKPI-VLNPNATTTPDPIISSSDHRSPPSSKIVLSVSAIIAISAAAVI
IRAKf_k-1_Smoe  CGGSTKPMCNV------------------------YRK--RSSETMGASAILGISIGSMC
IRAKf_b_Smoe    CGASLSIACPAIPKPI-VLNPNATTTPDPIISSSDHRSPPSSKIVLSVSAIIAISAAAVI
                                                             :   .:  :  .

IRAKf_k-2_Smoe  -L-LLVFIFLGIRWNQPKGFVK-------------ASKNSSQ-SPPSLVVLHMDMSCHTY
IRAKf_c-1_Smoe  ALGIVVVSVLNIRAQQAAPAAALKNNFFMADHNSSPSSSSEDLAIGKLVMFTDG-NDTKS
IRAKf_c-2_Smoe  ALGIVVVSVLNIRAQQAAPAAALKNNFFMADHNSSPSSSSEDLAIGKLVMFTDG-NDTKS
IRAKf_d-1_Smoe  ALGVFIVVILNIKVL-TRPKKTPA-EVL-VYESTPPSPDSSTGVIGKLVLFNPN-IPSKY
IRAKf_d-2_Smoe  ALGVFIVVILNIKVL-TRPKKTPA-EVL-VYESTPPSPDSSTGVIGKLVLFNPN-IPSKY
IRAKf_g_Smoe    VLLCFWGVFLYNKFGS---KQ-----------H-LAQV-TS-ASSAKLVLFHGD-LPYTS
IRAKf_m-2_Smoe  -L-VLLLVFLGIRLNHSKPFAK-------------GSSKTGQ-GPPNLVVLHMDMACHSY
IRAKf_g-1_Smoe  ALVCFWGFLFYNKFNAT--KA-----------C-IPQQ-PE-PSAAKLVLFHGG-LPYTL
IRAKf_m-1_Smoe  -L-VLLLVFLGIRLNHSKPFAK-------------GSSKTGQ-GPPNLVVLHMDMACHSY
IRAKf_g-2_Smoe  ALVCFWGFLFYNKFNAT--KA-----------C-IPQQ-PE-PSAAKLVLFHGG-LPYTL
IRAKf_n-2_Smoe  AVVLLVLVLLVQCTKQR-----------------VPRPPGNRGGRKEVVIFTNIGFRFTY
IRAKf_n-1_Smoe  AVVLLVLVLLVQCTKQR-----------------VPRPPRNRGGRKEVVIFTNIGFRFTY
IRAKf_a_Smoe    ALGIVVVSLLNLRSH-PRPRAS----FYVVD-SLPGSSPSEDLAIGKLVMFTDD-SDSRD
IRAKf_k-1_Smoe  -L-LLVFIFLGIRWNQPKGFVK-------------ASKNSSQ-SPPSLVVLHMDMSCHTY
IRAKf_b_Smoe    ALGIVVVSLLNLRSH-PRPRAS----FYVVD-SLPGSSPSEDLAIGKLVMFTDD-SDSRD
                 :  .   .:                                    .:*::

IRAKf_k-2_Smoe  DDIMRITD-NLHERFLVGRGASSSVYKCTLKNGKKVAIKRLYN-H-YPQNVHEFETELAT
IRAKf_c-1_Smoe  EELLPSAHSLLNKEQEIGRGGFGVVYRAAISDGRTFAVKKLVTAG-LVKSQLEFEKEVQQ
IRAKf_c-2_Smoe  EELLPSAHSLLNKEQEIGRGGFGVVYRAAISDGRTFAVKKLVTAG-LVKSQLEFEKEVQQ
IRAKf_d-1_Smoe  ENWQEGTKALVDKDCVIGYGPLGTVYKAVVDGGVALAVKKLSSLG-QITSQEAFEREIAI
IRAKf_d-2_Smoe  ENWQEGTKALVDKDCVIGYGPLGTVYKAVVDGGVALAVKKLSSLG-QITSQEAFEREIAI
IRAKf_g_Smoe    ADIVKKIN-LLGENDIIGCGGFGTVYKLVMDDGNMFAVKRIAKGGF--GSERLFERELEI
IRAKf_m-2_Smoe  DDVMRITD-NLNERFIIGRGASSTVYKCSLKNGKTVAIKKLYN-H-FPQNIHEFETELET
IRAKf_g-1_Smoe  KEVITKIE-RLDYKDIIGAGGFGTVYKLCMDEDCVFAVKKVGRSSDGSISERRLEKELDV
IRAKf_m-1_Smoe  DDVMRITD-NLNERFIIGRGASSTVYKCSLKNGKTVAIKKLYN-H-FPQNIHEFETELET
IRAKf_g-2_Smoe  KEVITKIE-RLDYKDIIGAGGFGTVYKLCMDEDCVFAVKKVGRSSDGSISEKRLEKELDV
IRAKf_n-2_Smoe  ENVVRATG-NFSVDYLIGNGGFGATYKAEMMPGLVVAVKRLSI-G-RFQGVQQFDTEIRT
IRAKf_n-1_Smoe  ENVVRATG-NFSVDYLIGNGGFGATYKAEMMPGLVVAVKRLSI-G-RFQGVQQFDTEIRT
IRAKf_a_Smoe    EDLLPTAQALLNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPG-MVETQDEFEKRVQF
IRAKf_k-1_Smoe  DDIMRITD-NLHERFLVGRGASSSVYKCTLKNGKKVAIKRLYN-H-YPQNVHEFETELAT
IRAKf_b_Smoe    EDLLPTAQALLNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPG-MVETQDEFEKRVQF
                 :        .     :* *  . .*:  :  .  .*:*::            :: .:

IRAKf_k-2_Smoe  LGHIKHRNLVSLYGYSLSSAGNLLFYDFMDNGSLWDILHGPVR-KVTLDWDARLIIALGA
IRAKf_c-1_Smoe  LGKIEHPNLVALQGYYWTSRMQLLIYDFVPNGSLYSRLHERTFGEPPLSWSERFKIAQGT
IRAKf_c-2_Smoe  LGKIEHPNLVALQGYYWTSRMQLLIYDFVPNGSLYSRLHERTFGEPPLSWSERFKIAQGT
IRAKf_d-1_Smoe  LKNVKHRNVVTLEGYYWSPPTKLLLTEYLPNDSLFHHLHQRMEGQLPLPWWRRFKIALGA
IRAKf_d-2_Smoe  LKNVKHRNVVTLEGYYWSPPTKLLLTEYLPNDSLFHHLHQRMEGQLPLPWWRRFKIALGA
IRAKf_g_Smoe    LGSIKHRNLVNLRGYCNSGSARLLIYDFLSHGSLDDLLHEREPHKPSLNWNHRMKAAIGS
IRAKf_m-2_Smoe  LGHIKHRNLVGLHGYSLSPAGNLLFYDYLENGSLWDVLHGPVR-KVKLDWDTRLKIALGA
IRAKf_g-1_Smoe  LGSIQHRNLVSLKGYCNAPTARLLITDFMPLGSLDEHLHERHAKDSLMTWEARLNIAIGT
IRAKf_m-1_Smoe  LGHIKHRNLVGLHGYSLSPAGNLLFYDYLENGSLWDVLHGPVR-KVKLDWDTRLKIALGA
IRAKf_g-2_Smoe  LGSIQHRNLVSLKGYCNAPTARLLITDFMPLGSLDEHLHERHAKDSLMTWEARLNIAIGT
IRAKf_n-2_Smoe  LGRIQHSNLVKLIGYHASEGEMFLIYNYFPRGNLESFIHNRSRG--EISWAVVHRIAMGI
IRAKf_n-1_Smoe  LGRIQHSNLVKLIGYHASEGEMFLIYNYFPRGNLESFIHNRSRG--EMSWAVVHRIALGI
IRAKf_a_Smoe    LGKIQHENLVNFQGYYFTPKLQLLIYDFVPNGNLHSKLHEQ----SVLPWELRFKVALGA
IRAKf_k-1_Smoe  LGHIKHRNLVSLYGYSLSSAGNLLFYDFMDNGSLWDILHGPVR-KVTLDWDARLIIALGA
IRAKf_b_Smoe    LGKIQHENLVNFQGYYFTPKLQLLIYDFVPNGNLHSKLHEQ----SVLPWELRFKVALGA
                *  ::* *:* : **  :    :*: ::.  ..*   :*        : *      * *

IRAKf_k-2_Smoe  AQGLEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHTS-TYVMGTI
IRAKf_c-1_Smoe  AMGLSHLHHSCQPQVIHYDLKSNNILLGVDNRPLISDYGLANLLPVLDRYAISSKFQGAL
IRAKf_c-2_Smoe  AMGLSHLHHSCQPQVIHYDLKSNNILLGVDNRPLISDYGLANLLPVLDRYAISSKFQGAL
IRAKf_d-1_Smoe  ARGLAYLHHDCRPQVLLFNLKSTNILLDDEFEPHISDYGLRRLLPKLDTYMTDRKLELAV
IRAKf_d-2_Smoe  ARGLAYLHHDCRPQVLLFNLKSTNILLDDEFEPHISDYGLRRLLPKLDTYMTDRKLELAV
IRAKf_g_Smoe    ARGISYLHHDCSPRIVHRDIKSSNILLDSNFEPHVSDFGLAKLLNENQSHMT-TIVAGTF
IRAKf_m-2_Smoe  AQGLAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFGIAKSICPTKTHTS-TFVLGTI
IRAKf_g-1_Smoe  ARGLGHLHHRCVPPIIHRDIKSSNVLLDRNLEACVSDFGLARLLEENDSQVT-TIVAGTF
IRAKf_m-1_Smoe  AQGLAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFGIAKSICPTKTHTS-TFVLGTI
IRAKf_g-2_Smoe  ARGLGHLHHRCVPPIIHRDIKSSNVLLDRNLEACVSDFGLAKLLEENDSQVT-TIVAGTF
IRAKf_n-2_Smoe  AEALAYLHDECQPRVLHRDIKPSNILLDNNLTAFLADFGLARLLGASETHAT-TDVAGTF
IRAKf_n-1_Smoe  AEALAYLHDECQPRVLHRDIKPSNILLDNNLTAFLADFGLARLLGASETHAT-TDVAGTF
IRAKf_a_Smoe    AQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSL
IRAKf_k-1_Smoe  AQGLEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHTS-TYVMGTI
IRAKf_b_Smoe    AQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSL
                * .: :**. * * ::  :.*..*:**.      ::*:*: . :   .       .  :.

IRAKf_k-2_Smoe  GYIDPEYA-RTSRLNEKSDVYSFGIVLLELITRQKAVDD-------EKNLHQWVLSHVNN
IRAKf_c-1_Smoe  GYMAPEFASQSSKVTEKCDVYGFGIILLELVTGRRPVEYMEED---VVILCDYVRALLNE
IRAKf_c-2_Smoe  GYMAPEFASQSSKVTEKCDVYGFGIILLELVTGRRPVEYMEED---VVILCDYVRALLNE
IRAKf_d-1_Smoe  GYVAPEMAVQNLRLTDKCDVYSFGVVLLELVTGRRPVQNLETD---AVVLCEYAKAAFEQ
IRAKf_d-2_Smoe  GYVAPEMAVQNLRLTDKCDVYSFGVVLLELVTGRRPVQNLETD---AVVLCEYAKAAFEQ
IRAKf_g_Smoe    GYLAPEYM-QSGRVTEKSDVYSFGVVLLELLSGKRPTDPGFVA--KGLNVVGWVNALIKE
IRAKf_m-2_Smoe  GYIDPEYA-RTSRLNEKSDVYSYGIVLLELITGLKAVDD-------ERNLHQWVLSHVNN
IRAKf_g-1_Smoe  GYLAPEYM-QSGRATEKSDVYSYGVVLLELLSGKRPTDVCFTA--KGLNIVGWASAMMLQ
IRAKf_m-1_Smoe  GYIDPEYA-RTSRLNEKSDVYSYGIVLLELITGLKAVDD-------ERNLHQWVLSHVNN
IRAKf_g-2_Smoe  GYLAPEYM-QSGRATEKSDVYSYGVVLLELLSGKRPTDVCFTA--KGLNIVGWASAMMLQ
IRAKf_n-2_Smoe  GYVAPEYA-MTCRVSDKADVYSYGVVLLELLSGKKALDPAFSDYGHGFTIVGWACLLIGQ
IRAKf_n-1_Smoe  GYVAPEYA-MTCRVSDKADVYSYGVVLLELLSGKKALDPAFSDYGHGFTIVGWACLLIGQ
IRAKf_a_Smoe    GYLAPECGCESFKVTEKCDVYGFGVVLLELITGKPPVEYLEND---VVILCDFVRSLADD
IRAKf_k-1_Smoe  GYIDPEYA-RTSRLNEKSDVYSFGIVLLELITRQKAVDD-------EKNLHQWVLSHVNN
IRAKf_b_Smoe    GYLAPECGCESFKVTEKCDVYGFGVVLLELITGKPPVEYLEND---VVILCDFVRSLADD
                **: **    . : .:*.***.:*::****::   . :           :  :.     :

IRAKf_k-2_Smoe  KSVMEIVDQEVKDTCTDPNAIQKLIRLALLCAQKFPAQRPTMHDVVNVILTLLPPPT---
IRAKf_c-1_Smoe  GRGMSCVEPSLEA-CP-EDEVLPVIKLGLICSSPLPSNRPSMAEVVQILELVRPLPG---
IRAKf_c-2_Smoe  GRGMSCVEPSLEA-SP-EDEVLPVIKLGLICSSPLPSNRPSMAEVVQILELVRPLPG---
IRAKf_d-1_Smoe  GRGLQCLDHEMSS-FP-EAEIMQVFRIGLLCTAQDPSRRPSMAAVVQMMEMLSINSNNDF
IRAKf_d-2_Smoe  GRGLQCLDHEMSS-FP-EAEIMQVFRIGLLCTAQDPSRRPSMAAIVQMMEMLS-------
IRAKf_g_Smoe    NKQKEVFDSKCEG-GS-RESMECVLQIAAMCIAPLPDDRPTMDNVVKMLESEMM------
IRAKf_m-2_Smoe  NTVMEVIDAEIKDTCQDIGTVQKMIRLALLCAQKQAAQRPAMHDVANVLFSLSPVPA---
IRAKf_g-1_Smoe  NRCLEIFDPHCRG-AQ-LESMEAVLEVAAMCIHPRPECRPSMATVAEILQEHHHS-----
IRAKf_m-1_Smoe  NTVMEVIDAEIKDTCQDIGTVQKMIRLALLCAQKQAAQRPAMHDVANVLFSLSPVPA---
IRAKf_g-2_Smoe  NRCLEIFDPHCRG-AQ-LESMEAVLEVAAMCIHPRPECRPSMATVVEILQEHHHS-----
IRAKf_n-2_Smoe  GRAHEVFIVELWEMGP-EAFLLETLKLAVMCTVDSLTVRPTMRQVVDRLRHMDQSS----
IRAKf_n-1_Smoe  GRAHEVFIVELWEMGP-EAFLLETLKLAVMCTVDSLTVRPTMRQVVDRLRHMDQSS----
IRAKf_a_Smoe    GKPLLCVDPKMVV-YP-EEEVMTLIKLGLVCTSPVPANRPSMTEVVQILELIKPLA----
IRAKf_k-1_Smoe  KSVMEIVDQEVKDTCTDPNAIQKLIRLALLCAQKFPAQRPTMHDVVNVILTLLPPPS---
IRAKf_b_Smoe    GKPLLCVDPKMVV-YP-EEEVMTLIKLGLVCTSPVPANRPSMTEVVQILELIKPLA----
                      .             :   :.:. :*       **:*  :.. :

IRAKf_k-2_Smoe  ------------------------------------VKKSSAGAANAAANAAVDSSANAG
IRAKf_c-1_Smoe  ------------------------------------IDNSNS------------------
IRAKf_c-2_Smoe  ------------------------------------IDNSNS------------------
IRAKf_d-1_Smoe  YDISAVDGFFIGTGMSITGSGRGLTCRAEASTCPPENTNGNVCTSP-----------NRD
IRAKf_d-2_Smoe  ------------------------------------------------------------
IRAKf_g_Smoe    ------------------------------------------------------------
IRAKf_m-2_Smoe  ------------------------------------LSKKSVSSNP--------------
IRAKf_g-1_Smoe  ------------------------------------------------------------
IRAKf_m-1_Smoe  ------------------------------------LSKKSVSSNP--------------
IRAKf_g-2_Smoe  ------------------------------------------------------------
IRAKf_n-2_Smoe  ------------------------------------------------------------
IRAKf_n-1_Smoe  ------------------------------------------------------------
IRAKf_a_Smoe    ------------------------------------------------------------
IRAKf_k-1_Smoe  ------------------------------------VKKSSAGAANAAANAAVDSAANAG
IRAKf_b_Smoe    ------------------------------------------------------------


IRAKf_k-2_Smoe  GANRRYVDDY------VDSKHRDNLSASSTTSGGHLFVKFGEVISQG
IRAKf_c-1_Smoe  -----------------------------------I-----SRSSSS
IRAKf_c-2_Smoe  -----------------------------------I-----SRSSSS
IRAKf_d-1_Smoe  DPNSQYAQNVRASCPDAYSWSGDNTKTFATGTGGTF-----TITFCP
IRAKf_d-2_Smoe  ----------------------------------------------M
IRAKf_g_Smoe    ------------------------LSP-SPS-DF---Y----ESSSE
IRAKf_m-2_Smoe  -NQRRYIDDY------AESKHADNLSASSTNSGGHLFMKFGEVISQD
IRAKf_g-1_Smoe  ------------------------LCS-STEEDGSCAS---EFSLKL
IRAKf_m-1_Smoe  -NQRRYIDDY------AESKHADNLSASSTNSGGHLFMKFGEVISQD
IRAKf_g-2_Smoe  ------------------------LCS-STEEDGSCAS---EFSLKL
IRAKf_n-2_Smoe  -------------------------------------------LPFS
IRAKf_n-1_Smoe  -------------------------------------------LPFS
IRAKf_a_Smoe    -------------------------------------------DNRS
IRAKf_k-1_Smoe  GANRRYVDDY------VDSKHRDNLSASSTTSGGHLFVKFGEVISQG
IRAKf_b_Smoe    -------------------------------------------DNRS